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<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y591</accession>
    <name>I4Y591_WALMC</name>
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    <gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
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    </reference>
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        <property type="nucleotide sequence ID" value="XM_006960767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y591"/>
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    <dbReference type="HOGENOM" id="CLU_037385_0_1_1"/>
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    <dbReference type="GO" id="GO:0016756">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447:SF2">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
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    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="35"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="290" mass="32051" checksum="0C76B9D7C9FF8357" modified="2012-09-05" version="1" fragment="single">LAGTFMQALKTLSGYTMHDIPKTTLDTIARPALAKPTASFYKRPLPPKCTSFTSSRGKEMFANALLEGNMEAYFPLASQFITQNEPAYCGLGSLVMILNALGQDPGRRWKGPWRWYEQEMLDCCRSLQSVAETGISLTEFTCLARCNGLKADVQPAPMGIDKFREDVKLASRSSGTFMVLSYSRKSLGQTGDGHFSPVGGYSEAHDSLLLLDVARFKYPSYWTSIEDAYEATLPLDKVTGQPRGYTLLSPVEPNEYSSTSPSVTTISLNKSTWKLFQIKMNNALRSLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5A1</accession>
    <name>I4Y5A1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_41735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5A1"/>
    <dbReference type="STRING" id="671144.I4Y5A1"/>
    <dbReference type="GeneID" id="18472228"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41735"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049047_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y5A1"/>
    <dbReference type="OMA" id="FKMWFFF"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005802">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTNS"/>
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    <proteinExistence type="predicted"/>
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            <end position="24"/>
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    </feature>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24698" checksum="584AD27FA85743A1" modified="2012-09-05" version="1">MIVVDVLVAILPSILYFEQIYYIIKSKENIGYSIDTSGILLFANSTRIIFWFGEHYQINLLIQSILLILTHLLLLYVCIRYSPPAYQSRYLDFWQWNKYYVYVLSLISYNCLLIGLYFILHRYHIFVNILGYLALGLEATLPIPQIIKNYQQKSLEGFKYTILLGWIAGDSFKVVYFILQSSPLPFALCSIIQVTFDIIIIIQAFLYKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I2</accession>
    <name>I4Y5I2_WALMC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960721.1">
        <property type="nucleotide sequence ID" value="XM_006960659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I2"/>
    <dbReference type="GeneID" id="18475124"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66544"/>
    <dbReference type="HOGENOM" id="CLU_903724_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5I2"/>
    <dbReference type="OMA" id="APYVITF"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="34654" checksum="7C21DCD5D75217F3" modified="2012-09-05" version="1">MIEISKQNFLTIVILILPAVAPKLIAASKRLSDLHTKDSFKRLETNEKAIRPLALVATVIVFNLIKTIKTALTAENLFSKLPINASQTLLENVYNPEHDESLSKFFSRLNSFDLRLQYIRWGDRATRQCTWCSPQSGIDFALESFSGTFAPYIITCLGLLFYIQLQQKLHLRKPLLITLCGTFLGHFATLNIYDTRPNPNFPPTILANKLTLLSYAFLTTISIYTLAVKPNKYLSSGADPISLLKPIVVPQKALLTSIKALNVTNEARRTLNLNQKVRSDRPKRGGSADIETYQLIEKEADQLADAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J1</accession>
    <name>I4Y5J1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960730.1">
        <property type="nucleotide sequence ID" value="XM_006960668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J1"/>
    <dbReference type="STRING" id="671144.I4Y5J1"/>
    <dbReference type="GeneID" id="18474616"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61577"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020696_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5J1"/>
    <dbReference type="OMA" id="SEETHKY"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="602" mass="67427" checksum="A2C90ED69578B987" modified="2012-09-05" version="1">MEDDSEYSTSDDELDILTLDQKLSLKPRASTESSLKSSSSSSFTPSSSILQHSSPTTSISDFQQSDDDDFLQDIHLPQNINFHSRLLQKINKRPFEPFEQDLDISQDIKLSPTRIQNSLLARASSKKPRSSAPAKVTPAPPVRSLHRRGSLSSLPRSPTRYSNQGPTQPSLRNAKSTFNFSQSRLTAPTASSLAKSKPAKMRPPSISIPAARVAMPSSAKLLTKPKNLKPKKIWGDGSELEAFEDLTTQTRTRTSMSGDEFSTIKARPSDTRSDRSSSPSGSTIQRKQVRERPSLFNTFFDGRSRSPQTPPPPPTISQSRYVPTRTARAHSPITIPIPNSTVTAPTLSSEAKRKQRLHSHSSFNRSLSPTSSQMMFPSIHQRTEESFPQKKTLRRSKRPTLIKQLGKEDQVKVVGDMKYNPVERKWDGNNYEPALRELETSRPALITHFNSTTTPNSSFNSLRARSPNSSGNGTSYLNQPTKIVGDMVFDPVRMCWLTNDEEDVFANLSSSSNSSRGSHYQRDQTAMTIFHHDTNNSQVSTIDTERAKIMANIPKELIDQCEFAEKQHDNDIQGWIPRGGIVDDRRYLYEIYVMSKKIAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5N0</accession>
    <name>I4Y5N0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960666.1">
        <property type="nucleotide sequence ID" value="XM_006960604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5N0"/>
    <dbReference type="FunCoup" id="I4Y5N0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5N0"/>
    <dbReference type="GeneID" id="18474594"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61542"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002512_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5N0"/>
    <dbReference type="OMA" id="LRRYMDM"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="454"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="931" mass="105850" checksum="66048ECFBDBBFE20" modified="2012-09-05" version="1">MKSSARKLLNRPYTQLDNLSNRQSRLTKSAFDSQRKSALKVINAAVTGHTWGLKKSNGLDYSNNLSGDFSPIKINPSDKEIWFEKHTTRDVQSGDFLYIPKFTQYGVGLATDIIDGRKVWWCLLSSGAIVAYPEQAVVYSAPLFKQGELKRTELFRAVEQIKKNPLAQHHIYNPENDSYALLKSKLVSRFKRMLFDVESTLRQYTLDFSKVFEKIRDKSDTKWREYDIITLLQREFKIHNPSRLQIMAFHMMLYRNTTEYNMIDNQAAIKEMRFSVRPKVEVEILRLVNEWMNTKEGREILISFVEKSRGLLKLSDSISKETGVMPKAITDIPSTLKYDERENIIIRLITDSCQTLNTPAFNPYESVVCVLLKNFDKYHHVNQENWRSLSFDFLQTIGLFAPWETIHMAGSTSVVPRDNDPDSRFKLLGDIAMKEHNSNGSTSLHVNDLLENHRRDFSKLPVYVIDDAGANELDDGMSVEPTDKDGNTWVHVHIADPTSVIPFNHPLSILAKERHTSVYLPHRTIPMLPKEFCMSNFSLGSRSPQQALTFSAQLDDKGRIRNYDVSPSFINNIKIMQYNAVDEVLGADALQNDNRLLDKSPNKASNTSISTEDIDTLGRVSQLAVLHSTRRVENGMLFWHTFTPEAQVTPLPLPTPPSELALWDGRPSVKLLAVPNVQQSPARFAVSQFMSIACEVTALWCRDHDVPGIFRGAGLPEVNDPSSLEDLMGKRDIVTGVVSSADVGKSMASFSGSTLSTKPIPHLLNGCPDGYARVTSPLRRYNDMVSHYQIKSAILSIRQPRDKISWMYPTHDSLAQYLIRTKQNDSIYQRLSNNVNAYWVVRELKKRYESNPSLFKDLRCTLISAWKNDGALTRSFADCEIAQLGGMKARIYKENSVSQEESFKDIGNVVSASIADFQLYEKSRIIVKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5P3</accession>
    <name>I4Y5P3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960678.1">
        <property type="nucleotide sequence ID" value="XM_006960616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5P3"/>
    <dbReference type="STRING" id="671144.I4Y5P3"/>
    <dbReference type="GeneID" id="18475785"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70729"/>
    <dbReference type="eggNOG" id="ENOG502SBIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070891_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5P3"/>
    <dbReference type="OMA" id="MVETHKI"/>
    <dbReference type="OrthoDB" id="3365220at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="31246" checksum="9E82A938FE3C2A9F" modified="2012-09-05" version="1">MFKRAVKRQKRVELEDKLGLREDLRGAVSDSDESSDSESESENEQISNSASDDEQENSEPSDEEGEEIDEDNEDGVEDDLDESDEELEELSINDALINPLFGEYPRKRCAICPGRLLTFEKFGSQHLESKAHTRRLNRFFTFVDEQKLNKDDDVHSTIDAFNQQLGTTPKEKSKKEENRIKRARIARQKRLERKLEAKKTLPVPLDEVEKKHVENNSGDAPDAAKEAKRAERRIRKKANKAKFAEERRQTEKSKKDTTDKEEKQNKKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R2</accession>
    <name>I4Y5R2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_34169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960696.1">
        <property type="nucleotide sequence ID" value="XM_006960634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R2"/>
    <dbReference type="FunCoup" id="I4Y5R2">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5R2"/>
    <dbReference type="GeneID" id="18471829"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34169"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y5R2"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="130" mass="14720" checksum="A82BE4B2B417E44F" modified="2012-09-05" version="1">MVSQIKPKIVKKTKGSFNRFQSDRFHRVSSSWRKPRGIDNAMRRRFKGQPTMPKIGFGSNKVTRHLRPNGLKTVVVNNTKDVDLLLMHSGKFAAEIAHNVSSKKRVEIIARAKALNVKVTNAAARLRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5V3</accession>
    <name>I4Y5V3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatase phospho-type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960621.1">
        <property type="nucleotide sequence ID" value="XM_006960559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5V3"/>
    <dbReference type="STRING" id="671144.I4Y5V3"/>
    <dbReference type="GeneID" id="18474582"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61522"/>
    <dbReference type="eggNOG" id="KOG3120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068983_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5V3"/>
    <dbReference type="OMA" id="HNLADCF"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27951" checksum="BF873C6D7B01C607" modified="2012-09-05" version="1">MSKQLITFDFDWSLSEQDTDRWVFEVLDPKKRRQMKSLKSTVQWTDLVAMKMKELHADGITREQVEESLRQMPFHPAMKRGLINLKERNKDIDLVILSNSNEVYIRTILEHHKITHLFDSIITNRASWTEDGCLDLKRRVDPNGEQHKCVVGCSPNMCKGEELERYVESKGGWSNYKKVFYVGDGGNDYCPLLHLRQQDTALARYPRPLINRIEKEGNLKCSIVKWVGAWEIEEIVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5V7</accession>
    <name>I4Y5V7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960625.1">
        <property type="nucleotide sequence ID" value="XM_006960563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5V7"/>
    <dbReference type="GeneID" id="18475118"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66458"/>
    <dbReference type="HOGENOM" id="CLU_1062474_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5V7"/>
    <dbReference type="OMA" id="IVSEIEC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697420" evidence="2">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="262" mass="30580" checksum="0C3503688314C352" modified="2012-09-05" version="1">MYFNIAKATAVLAFTAAIASAAATPHTGVRRGDDKDYGKSTKEYYGEGQKKDYKDGKHEEDSYAKQLKKHEEEVEKQLKLTKEAAEKNKKGADTKHKDKKYRRGDKEDDKDGKHDDKKSTVYQKPSSTKSGEYAKFTDYWKSKYDDKDDNKKDKEDDKKEGKDVKQDDKKAGYDDKDYYKNLQAQKQNTKEYEEAVKKYGIKDDKKDVKKDDRKDDKKDDKYDKGVKKDDHKDAKKDDKDNVDHEKYDKKHDKADKASYNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y0</accession>
    <name>I4Y5Y0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase 1</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Microsomal cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_34053</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 24">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960522.1">
        <property type="nucleotide sequence ID" value="XM_006960460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y0"/>
    <dbReference type="FunCoup" id="I4Y5Y0">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Y0"/>
    <dbReference type="GeneID" id="18471803"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34053"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y0"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM19372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="290" mass="32189" checksum="C2D996981008862E" modified="2012-09-05" version="1" fragment="single">MAELPALRDPYFLAAVAGIIIAFGLGGYLGLFSSKPKPVLDPKEFKEFPLVEKHKLSPNTALYRFGLANKTDVLGLPIGQHISVQAEINGKQVMRSYTPTSSDDDKGHFDLVVKTYAQGNISLFLDKLQLGQNVRIRGPKGQFKYDENLTHHIGMIAGGTGITPMLQVIRAILKNPRDTTQVDLIYANVTFDDILMKKEIDDLVKQEQDNGKNRLRVLYVLNSPPASWDGGIGFVNKQMIEERFPPAAKEGKVLLCGPPPMINAMKNHLNELKYPAPRAVSKLSDQIFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y631</accession>
    <name>I4Y631_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Act1p</name>
        <name evidence="4" type="ORF">WALSEDRAFT_41424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960573.1">
        <property type="nucleotide sequence ID" value="XM_006960511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y631"/>
    <dbReference type="FunCoup" id="I4Y631">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y631"/>
    <dbReference type="GeneID" id="18472214"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41424"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y631"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="375" mass="41758" checksum="0F364EDF6B16AED7" modified="2012-09-05" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAFYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAIIRLDLAGRDLTDYLIKILMERGYPFTTSAEREIVRDIKERLCYVALDFDQELQTANQSSALEKSYELPDGQVITIGNERFRAPEGLFKPSLLGLEAAGIHETTYNSIMKCDLDIRKDLYGNVVMSGGTTMYHGIPDRMQKELTGLAPSSMKVKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y648</accession>
    <name>I4Y648_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_66303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960472.1">
        <property type="nucleotide sequence ID" value="XM_006960410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y648"/>
    <dbReference type="STRING" id="671144.I4Y648"/>
    <dbReference type="GeneID" id="18475106"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66303"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091459_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y648"/>
    <dbReference type="OMA" id="HYELLEW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="23509" checksum="92A7179696C26EDD" modified="2012-09-05" version="1">MSTPPIHSKAEIPINSPTSEQAAKIVISAADNDLDSLVNYKNDFGPDSIFTARDDVGHSILHAVCEKGHLEILEWLLPPHLPYPPGPSPSNTPLFSSSLSPTPHLTQALIDSNTPDQRSPLHYAARKGHFECVKSLLSFASTRPAALDPSSYSKKDVPKGAARAADAIEGRQKTAESILLEKRTSRGRLAQDEAQSGGHTQLAEFLNERRLCLTNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I6</accession>
    <name>I4Y6I6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_70499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960376.1">
        <property type="nucleotide sequence ID" value="XM_006960314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I6"/>
    <dbReference type="GeneID" id="18475750"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70499"/>
    <dbReference type="eggNOG" id="ENOG502SD56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1046641_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6I6"/>
    <dbReference type="OMA" id="SICCFFT"/>
    <dbReference type="OrthoDB" id="2502001at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697565" description="Thioredoxin-like fold domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30675" checksum="944EE0BA6F313BB1" modified="2012-09-05" version="1">MKNVIWICLSVCLLLSITSAGIVEDLVGKATGINVTQKIEEQNKLSEYAHNINDSQWKLLVENSNQDNVWLILITSGKQDEFERLLKESFNNLAEETRDDDNIKLGRADCKRRPHYETLLMEHSDGNDIRSLSTRWLLFQVPIYVFTDDNGRTLRFMSPYHYTPSSTNLRKLLLEKGYKDLPIWDSEFSYEGKYARYMDVYTNLSLYLHSKLDVIPSIVWYIGIASASSSLLKWMHKDDKKNLARQKGSAEKDNASAHTRSKTAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6L3</accession>
    <name>I4Y6L3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960403.1">
        <property type="nucleotide sequence ID" value="XM_006960341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6L3"/>
    <dbReference type="GeneID" id="18475100"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66239"/>
    <dbReference type="HOGENOM" id="CLU_141809_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6L3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16815" checksum="415DCC9045E799EC" modified="2012-09-05" version="1">MTESERNATSTDTQEVSAQENERRLKDLNKSDKDTSKLLKKSEKDYKNAEKHLRDAEKAESQATKNIDKTMKEQQKAEKKKIDAEAQFNRANMFSDNAKKELDQAKELHEKRKAEFEQITTDRQNARERRNRVEQELNKRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6M8</accession>
    <name>I4Y6M8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_33886</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960283.1">
        <property type="nucleotide sequence ID" value="XM_006960221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6M8"/>
    <dbReference type="FunCoup" id="I4Y6M8">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6M8"/>
    <dbReference type="GeneID" id="18471767"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33886"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6M8"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="346"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="455" mass="51319" checksum="47E7077554E8C12B" modified="2012-09-05" version="1">MRFQTWRKLWLNLAIAEKELGLPISDEAIKQMSDNLTIDEDQMKIAAEEEKRRRHDVMAHVHTFGVVAPEAAGIIHLGATSCFVTDNADLIFLREGLNMVIEKIAITIDRFTAFADKYRDLPTLGFTHFQPAQLTTVGKRATLWIQELLWDLRNLTRARDDLGFRGVKGTTGTQASFLALFDGDHDKVEALDKRVTELLGFPYAYPVSSQTYSRKIDNDVVLALSNFGSTVHKIATDIRLLAHLKEVEEPFEKDQIGSSAMAYKRNPMRSERACSLARHLISLSQDVLNTSAVQWFERTLDDSAIRRISLPSAFLTADILLSILQNISEGLVVYPAIIGRRISQELPFMATENIIMAIVKKGGDRQECHEKIRVLSHEAGREVKEFGRENDLIERVKKDSFFAPIVNDLDKLLDPKSFVGRAPEQVDSFILNWVKPALQPHQEVISNAKAAQLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-10-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y8</accession>
    <name>I4Y6Y8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PNK3P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960238.1">
        <property type="nucleotide sequence ID" value="XM_006960176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y8"/>
    <dbReference type="STRING" id="671144.I4Y6Y8"/>
    <dbReference type="GeneID" id="18473035"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58584"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014938_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y6Y8"/>
    <dbReference type="OMA" id="KPEIGMW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="23750" checksum="DA0E73C7F145479D" modified="2012-09-05" version="1">MTTRQSTLNFSKKASKIIWKHNKPFNQPRTIIFGVYGQFVPHRKIAAFDLDGTLIKPKSGSTFPKHASDWKFLHKNLKERLSSLIDDGYAVIIISNQNYESRPAKLEEWQRKLEFIGDKLEDIPFVCMAATSKDENRKPNVGMWECLERYLEAQEVGKPDISQSFYVGDAAGRPRENRRPADHSSDDLNFAKNLDLQFYTPEEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y740</accession>
    <name>I4Y740_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_40785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960116.1">
        <property type="nucleotide sequence ID" value="XM_006960054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y740"/>
    <dbReference type="FunCoup" id="I4Y740">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y740"/>
    <dbReference type="GeneID" id="18472191"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40785"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y740"/>
    <dbReference type="OMA" id="ICGVFEE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="33539" checksum="FDBFD03A438AE5F2" modified="2012-09-05" version="1">MITKNIVNYDKKHSFVTGGSQGLGLSTAIELIKRGSNVTICARNKSKLSKAVDELTKYKVYDDQYIGYTIADLSDYSQTISALNKAKRDSGETPSMIFCCAGCSTPGWFAEMSVDNFMKDMQTNYYSALWTVKAATSIIIQDGIKDSHVTLVSSVLGFPLGLPGYSSYTPSKHAIRGLGDTLRTELQLYDIRTHVYFPGTIYTPGYETENETKPALTKKIEGAADGLTPQECAIALLKGIDKDEYQITSDFVGSLIKNISRGASPTNNILIDTFYLLIAAIAFPFWRIYMDYLVKSEKKVKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y745</accession>
    <name>I4Y745_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960121.1">
        <property type="nucleotide sequence ID" value="XM_006960059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y745"/>
    <dbReference type="GeneID" id="18475712"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70314"/>
    <dbReference type="HOGENOM" id="CLU_1455460_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y745"/>
    <dbReference type="OMA" id="HVWAIRI"/>
    <dbReference type="OrthoDB" id="3360573at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="20781" checksum="AFE9796B75DD2BA5" modified="2012-09-05" version="1">MTTINDQFLKNTINRINDLSRTSLTVDKDGLLSLGHNKLDSTRKQQLLEFALVARHSADEISSSSLLVGHNSETDDFGDVPFTITVDRDEDIAHRSPNDIARLILNQLQLNYTLIVEDDAIAQRLPKSSETILNDSQKKTIIEKCSAVGQPTLDFSASISNSENISIWAIRIAERQYLGLLTISVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D5</accession>
    <name>I4Y7D5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960019.1">
        <property type="nucleotide sequence ID" value="XM_006959957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D5"/>
    <dbReference type="STRING" id="671144.I4Y7D5"/>
    <dbReference type="GeneID" id="18475701"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70231"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7D5"/>
    <dbReference type="OMA" id="SQIHGTQ"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="20054" checksum="5C351A82546650D2" modified="2012-09-05" version="1">MSRFKNDSLWIETDTGNRISKKAVICAPVNIILSGNVIIKPEVIIRGDLRRTGPSPSVAISIGKFTILDDGCIIRPAYKTYKGTFSYYPMKIGDFTTIGSQTILEAAQVGSYVEIGRNCVIGRFVVIKDCAKVAPNSVIPPNTVIPPYALFSGNPAVQIDTLPESTLDNVELSTTTSYNEFKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G5</accession>
    <name>I4Y7G5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960048.1">
        <property type="nucleotide sequence ID" value="XM_006959986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G5"/>
    <dbReference type="STRING" id="671144.I4Y7G5"/>
    <dbReference type="GeneID" id="18471734"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33711"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y7G5"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="179"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="50786" checksum="4F54B4D0BFD59E6F" modified="2012-09-05" version="1">MFRLSSLRNSLRAPSLASRCFNTTATKLQSPTVGTSSATVEDMHDLSAEEILRDSGDRKDADLRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRGTEKLMEYKNYVQALPYMDRLDYSSAMTNELSYTRAVEKLLNIEVPERAQWIRTLFSEITRILNHIMAVLSHAMDVGALTPFLYGFEEREKLMEFYERVSGARLHAAYIRPGGVAFDLPHGLLEDIHKWATQFSSRIDEIEEIVTGNRIWKERTIGVGRVTADEALDYAFSGPMLRGSGIPWDLRKTQPYDKYSEVDFDVPVGENGDCYDRYICRVQEMREAVRIIGQCCNKMPPGPYKIDDHKIVPPPRASMKESMESLIHHFKIFSEGFSVPQGETYTAIEAPKGEMAVHLISDGSNRPYKCKIRAPGFAHLAGADFISRHHFLPDMVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G6</accession>
    <name>I4Y7G6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960049.1">
        <property type="nucleotide sequence ID" value="XM_006959987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G6"/>
    <dbReference type="FunCoup" id="I4Y7G6">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7G6"/>
    <dbReference type="GeneID" id="18474416"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61248"/>
    <dbReference type="eggNOG" id="KOG2570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023529_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y7G6"/>
    <dbReference type="OMA" id="NFRCNEP"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="468" mass="53793" checksum="4FEAE32CEAC9C0C3" modified="2012-09-05" version="1">MNSYSQMGYSQSPSQQPTQQPASVQNIYTQAQAQQTAQNVNSSQLGQTKKRQSDLEEALKQYKKKRPTDRSLPPSIQGIDSVREQSKMYDDLLRFEKRLDMISAHKRSQIHDSLQRPAKTTRQLRVFISNTASGQPWQQQQDGVVNFETGTGIPAWTLKIEGRLLDGNTTKANRGPPRKFSSLLKSMIVEFDRDSSLYPESSIVEWHRQPAEPEKDGFEIKRRGDQSLKARIIIHLDHIPEKYGISEPLSQLLGIKEDSRAGIITHMWAYVKQNNLLDKEDRRIIKADDNLKSIFGCDSIYYHQLPEVVQKFLLPVDPVVLEYNIMVDKEQTFAEHAYDIEVDVEDPIKQKMNNTISTYMPNHELSQKISQLDEEISQSAVAVRNAVIKRDFLDEFSKDSAAFIKNWINSQSRDLDLILGTEHANVPLEEMRRADFYRRDWVQEAIIVAESKLYAEKKSKLSQVNPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7M4</accession>
    <name>I4Y7M4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tricalbin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959897.1">
        <property type="nucleotide sequence ID" value="XM_006959835.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y7M4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="GeneID" id="18471717"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33612"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001661_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7M4"/>
    <dbReference type="OMA" id="VLMDDYM"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="306"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="502"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="650"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="774"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1353"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="950"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1334"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1487"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1487"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1539" mass="170472" checksum="8C8FA5CC33D8A5CC" modified="2012-09-05" version="1">MSEQTQPRRSASLFRRRSRSSSVASSVKNGSSPYQQEDLPPVPPMPDNANEKAKKKFGPIPVPRFGISRTSSKQSTANNDRVHKEDVKEGFKKDEQHAKVHSFDPNEPTSQKEAELKETQKSTTDGVEGDNLPKPPTKDEEQPEAVPEASIVPPKQQKTTPAQTTAQKGEEAFKSAPIYAIDDIPGYLSHKEDNLPSTTLPKWYMRSKELPDSLGAQSFDITGAEDDGGSTLLPEKFYGQWFHNAAVVLVSSLFTYTLAYFNFGIGPLAIVGIASVTYYNISISKVDKDVKDGISRQLMKPALESESESADWVNNFLMNFWTHLEPYICEQVITNVEPIIAQYKPGFIKSVRLAHLTLGSKAPRILSVRTWPSTADNIITMDWKVAFTPANLGPLGEGQTEGIVNPKIVVQVVVGNGKFTTTLPVILEDFSFLGNMRVKLTLINDFPHVKLVDLSFIEKPEFDYIAKPIGGESFGLDVNYIPGLTTFIREQVYGIMQPMMFDPNVFTLNLQEILAGGALDSACGVLVITIRQARGLRSTKIGSGAPDPYTTITVGNSKTINDKTKTLTSTDNPVWMETKYLLVNSLNDQLVLNVYDYNEVRKDSDIGLATINLQSLANDPVQELVIAKLLNGGKERGDIRFDLNYYPVMEPPKEGESLEAVPDLPTGVVRLYVHEAKDLDTSKSKLGRINPAASVFVKGKQVQQTNMVRHTKSPVWDSHSEFLAANKDKTKMQVKIYHAHNFKPSMPLATVNVDLSDLLDADDKEGKWYNLGKTSGQVRLSASFKSVAMDGALDGAGQYTPPIGLIRVFCKCAHDLKNVEAAFGGKSDPYIKAILGGKVYGRTNVIDNNLSPVWNEHLYIPIHSLRDVIYLEAVDYQNLTKDRPLGHTTLRARDIIKENDNDEERKNMPYIATGINRRTSPMKLDKGGYKGELEYQAEFIPAWKIKGSTFENEEEKKEEEAKIAEEKKEEEKNKEENGTENVSGEEEEEEEESAGLELTEDELLERESGILVVNCESGELAHKNSRLEFLLDDAIWPTFSTEKARSKKANWNHIGEGLVRELSFSQLRIRLNTGEQDENDQVYAETSMDVREFLYRTLNKEAEFTLSNDEGDNTSKLKLSSRYVPVEIELSLRESVNNQGNLRVEVHNAKGLASADRNGKSDPYAVFLLEGEKVYKTETKKKTLNPEWDEYFEVEVPNRVDGNFMIEVYDWDRMSAADLLGVAKVDLTAFEPLESTEFTYDLKDGESGDQGNIKVSFVFKPSFIIKTRSRTSTFSHAGRALTQVGGIGIGAGKGVVHGAGHIGKGAMSGAGFIGSNVGGAVGKAGGLFHIGKKKSPSMGGNESFVDEGNSAPRSNNAQMSDKPASRVEVGDLNVTIVKAWDLKGEGHHEQPKPKPVLRMGRYKVEGKSAGKTSEPSFDESFILHTKPEKPTFSIEIVDKHLFGDRQIGYNNVMIGHYIHPEKNENSAEFDLELLGAGGYVTLKLQWSPSESRPSTSSMVNDTTNDNTEADDTQSVSSKLKSGKSSRFASLGRNSVHKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V8</accession>
    <name>I4Y7V8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_61210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959979.1">
        <property type="nucleotide sequence ID" value="XM_006959917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V8"/>
    <dbReference type="FunCoup" id="I4Y7V8">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V8"/>
    <dbReference type="GeneID" id="18474394"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61210"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y7V8"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697691" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="341"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="491" mass="54312" checksum="FBCD31B31E3C4E93" modified="2012-09-05" version="1">MKLKASVAAGLLAFLASVHANENNEPSDVVSLTKDTFSDFVNSDLSLLSFTAPWCGHCNRLKPEYKSAASTLKSKDIPLGNVDCTEQAELCAEHEVGGYPTLKVFRKGLSTPYGGTRKADGIVSYMTRQSLPAVSSITPQNHDEFKQSDKVVVIAYNLKPNSDLYNTFHSTANTLRDKHLFGETEDSTVAKQAGVSGPSVVIYKSFDEGRNDVDTKSLDEKTLIDTISVNSVPLIDEVGPENFAHYATSGLPLAYLFVNPEDPKLESRVEELKPVAEEYKGKINFVWIDGVKFVEHGKALNLVKDEWPGFVIQDLVEGNKYPFDATKDVNKKNIASFVKDYSNGKIQPSIKSQPIPEERVVDGVYQLVADEYEKVALDDKKDSLVAFVAGWCGHCRALHPKYNELGQRFSGDDGVVIARFDATENDVPDNFSITSFPTIKLQPAGTKGWIDYEGDRSVEDLEEFLNKNRATKSSSQAEQKPAHDEHKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Z0</accession>
    <name>I4Y7Z0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_48000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959803.1">
        <property type="nucleotide sequence ID" value="XM_006959741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Z0"/>
    <dbReference type="FunCoup" id="I4Y7Z0">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Z0"/>
    <dbReference type="GeneID" id="18472435"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48000"/>
    <dbReference type="eggNOG" id="KOG3422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Z0"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="22026" checksum="7ED98D7BCD2054B7" modified="2012-09-05" version="1">MLNQLVNSFRNSLSFNKTLQQNTQQLRFRGQLAPRRTKYRKSHKGRVGCPTGGSTAGTTLAFGEYGLRVKQGARLSAKTLQSCEESIKRKIKPLKGSQCFMRVFPDIPVCVKGNETRMGKGKGTFEFWACRATPNKIIFEVGGGGMRAEVAQEALRLAQAKLPVKTEFVRLSDPPKLGNTYVAHPRSNAGPAGPGIADSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y858</accession>
    <name>I4Y858_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959871.1">
        <property type="nucleotide sequence ID" value="XM_006959809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y858"/>
    <dbReference type="FunCoup" id="I4Y858">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y858"/>
    <dbReference type="GeneID" id="18474359"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61149"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042543_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y858"/>
    <dbReference type="OMA" id="NEVLWFM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="345" mass="38945" checksum="0CF51DB9CE1ADAD2" modified="2012-09-05" version="1" fragment="single">MSSLIKKSIIPLLAISSAYLYLKPTNPALLESDVLLDGYKVLSQQRIVAIGDLHGDYQRTLDALRVTQLIDENDNWIGNKTVLVQTGDITDRGADMVPIYQFLEKLRVQAAEVGGSLHTILGNHDIMQPMRDWRYVHPTEMTYFNGDLTQREQAFSKDGWIGKLWLKDYLTTVNIPHYSENDGQKYNLPANLSTQFVHAGLHPSFAYKELNDDGKRWLEKLTNGDRNWSDVEKSLWSPNGPYWFRGAALDNETKACAMAKEVMQTIGAKRIVQGHTPNFDNIVSRCNGGIILIDTGMSKAYGGIVSALEINGYILSKDDKHYFREIVKALYQNRSVTLVDETNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8M3</accession>
    <name>I4Y8M3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959572.1">
        <property type="nucleotide sequence ID" value="XM_006959510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8M3"/>
    <dbReference type="FunCoup" id="I4Y8M3">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8M3"/>
    <dbReference type="GeneID" id="18471667"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33381"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_21_2_1"/>
    <dbReference type="InParanoid" id="I4Y8M3"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="260" mass="28352" checksum="2A1B8AC4DED439B6" modified="2012-09-05" version="1">MSNIPGKDVDRNQEATIYIGNIPEAVSDAIIWELMLQAGPVASVHLPKDRVSMSHQGFGFCEFVNDEDAEYACKIMNQIKLYGKPIRVNKASTDRKQIDVGANLFIGNLDPGVDERLLFDTFSTFGLMMDVAKIARDDTGYSKGYGFIQYNDFDSSDQAISAMNGQYLMNKPLTVDYAFKKDGKGERHGTEAERMLAAEAKRNNALPMPGAIPGQPFMQYQGMFAGALSGNAPVMPGQPAATPTPYGFTPVPPPAPYGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T4</accession>
    <name>I4Y8T4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959633.1">
        <property type="nucleotide sequence ID" value="XM_006959571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T4"/>
    <dbReference type="FunCoup" id="I4Y8T4">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T4"/>
    <dbReference type="GeneID" id="18474293"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61027"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8T4"/>
    <dbReference type="OMA" id="KMEDQEY"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="114" mass="12845" checksum="428C277CF18D13F8" modified="2012-09-05" version="1">MLGNGRLEASCFDGVKRLGHIRGKMRKKVWVGAGDIVLLSLREFEDEKADIIHKYSPDEARALKQYGELPSEARINENEAFGDDDLEGEIEFGEQEEEGEDDDSEESDVDINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U9</accession>
    <name>I4Y8U9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_20663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959647.1">
        <property type="nucleotide sequence ID" value="XM_006959585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U9"/>
    <dbReference type="FunCoup" id="I4Y8U9">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8U9"/>
    <dbReference type="GeneID" id="18470849"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20663"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_15_1"/>
    <dbReference type="InParanoid" id="I4Y8U9"/>
    <dbReference type="OMA" id="QARIIHC"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="106"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="441"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="453"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="597" mass="66420" checksum="0A59AA5EEBD5E5D7" modified="2012-09-05" version="1">MNKSPESVYLSPYVNMRQQSFTRAPPDGVSLPPSYTNPTTSLTLELSQLYNKCNNLYSYKPSNNPRRVLTKPSKPVHNQGYDNQDNDYILYVNDWLGGGSSGTNNYLIIDILGQGTFGQVAKCQNVATGEIVAIKVIKNKPAYFNQSMMEVTILELLNNQFDNQDNHHILRLMDQFIHCKHLCLVFELLSSNLYELIKQNSFRGLSTSLVKVFTSQLLDALVILNQARLIHCDLKPENILLKSLQSPQIKIIDFGSACHERQTVYTYIQSRFYRSPEVLLGMPYSSAIDMWSLGCIAVELFLGLPLFPGTSEYNQITRIVDMLGLPPSFMLQSGKQSHEFFETYLDEFGKSQFRLKSLEKYSQEHNTQEQPSKKYFSASTLPEIIKQYPVSSSKAKSESDLKKEQANRLSFIHFVQGLLNMNPIERWSPQQARLHPFITGEQFTGSWTPPNLPSGNKSGSPSGSTLHASSNNPMSPSSSQIQHFATGTPTAPPAVAPASVPPTPTDQVRPYGGLQASSKSPSRPYQNAQAYNQQLAQQSNYLGQQASAQIAAANAYRNPFPPPPPPATNKAQPPLPGGAAAYSSPRYQKQNVYPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8W4</accession>
    <name>I4Y8W4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_5134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959432.1">
        <property type="nucleotide sequence ID" value="XM_006959370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8W4"/>
    <dbReference type="FunCoup" id="I4Y8W4">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8W4"/>
    <dbReference type="GeneID" id="18472553"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_5134"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8W4"/>
    <dbReference type="OMA" id="CAISPEM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="73" mass="8536" checksum="2325D42E33251803" modified="2012-09-05" version="1" fragment="single">GPFFRSFPNLLELKNTNQVIKTNARNCTILPNFVGMKFAVHNGKNYIPIQVTESMIDYKFGFFVPTRKKFSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Z6</accession>
    <name>I4Y8Z6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959464.1">
        <property type="nucleotide sequence ID" value="XM_006959402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Z6"/>
    <dbReference type="STRING" id="671144.I4Y8Z6"/>
    <dbReference type="GeneID" id="18472989"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58133"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284860_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Z6"/>
    <dbReference type="OMA" id="ILEHEYA"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="1">
        <location>
            <begin position="578"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1199" mass="137000" checksum="790AB480692ADEC9" modified="2012-09-05" version="1">MYDNDECIEISTKINNLNSKLILNLNNYLFIFNFNFKILNFYTLPFRPKSIGCYDDLVFIEGDDCLDIIKLDGRIHLVHSINLNGIISYTHHRHLTVVLTKYKLLLYKHYRLSQSVDLHSDPQLASISPNLDLLALSYKDSSTVHLYSITDTPAQLQLLPHLSLIRSIQWRDNNLLIIETVDNDLYAYHRSSPSKFEPWTIYVSPSLLRSFWLGPSTTDLLLRRALSDSNYLLHQSNPLSSLIAERRYERVSQISQYSRDLILNISSDGYNLTINAIHDTTHESSNYIRSQPVVHIKLPDSIPNDIIDIEISCQDHNYSPIYLLALRDNNKGILVGILNPASIFDPIPDTKAHPPIEWLRNIHHTQHFDSITKINTDSFGHSLSTYSHNEKRLINWNILDSPSNALHKLRMIESGSNFNSLDEVLDFICVNDVTVIAFKNDMKVFRNNDLITNMPSKLSSSVTFTNTSHHIYVIEYNNSEVSVRWLSLKNCVVEYEQSSPVDLKQLSVSSAKFVNKHFVPSYKSRSRDQIKVKFSSPIVTILDRNNMIRFLRLSRNELKSLPITTAIDCPENIVNIQSCFKTHHTAIVSSDAKGSYLRVYKPTSNKYGSDLEFEYRSCGEIRDVEFLFLDDFEEGLCLLFNERSSAKVFISTHDEQKRWIELTTLTLPDYESGRTIDHVTFLQNASIGLLCGSNLHIQSILHLMSVDIKPYARDAPLCQSSLYELTAELAGPVQEWHNIFLINCLRLNEYGVLKRIFKYLQRAVKTQNTGDLHAKFVQEVDDKDDDSDEKWPQVDDEFLQSIATLKGVVGNEGLYNELKCTIEAINYAYNVAKNADENTWRFLVFSKLGILADNSVIFGHLSHNHQLLIEQLEETKSVDEIRSTYPSLWIGDSDLYQQLMDRLAKKMAVNHEDEIDPTLYGSSLIYFALGKKNSVSTLWKFAYGHRERDNILKFLLKDFDNDNNAKVAATKNAFALLSKRRYGLQALDYAAAFFVLAGKTKDAIQVCLKQCQDFEMALCIARLRGDWELYTDVTKELAKYAVKSRNRALASVTISKLGQHHLASRCLVESFSTLLSDLVEELGEIKENDLANKYDFDISLVSVYLAQPGVLRVVDERELALYTAKQLRKNGTHALALRLLARWKFPKSSKEVPKPYFAAMLAPDPISRASSTPKTNVIASTPKQSSQHVDQFDMSAFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y928</accession>
    <name>I4Y928_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_3872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959496.1">
        <property type="nucleotide sequence ID" value="XM_006959434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y928"/>
    <dbReference type="STRING" id="671144.I4Y928"/>
    <dbReference type="GeneID" id="18472077"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_3872"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164187_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y928"/>
    <dbReference type="OMA" id="CKQIQDQ"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="67" mass="8210" checksum="553ABCE51F371CB2" modified="2012-09-05" version="1" fragment="single">RMEDGRRMFQVFAARMFEQRVLQAYREKVAQERQLQLLRELEEEDKVAADKEAKKAKENQRKKDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9E7</accession>
    <name>I4Y9E7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959379.1">
        <property type="nucleotide sequence ID" value="XM_006959317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9E7"/>
    <dbReference type="FunCoup" id="I4Y9E7">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9E7"/>
    <dbReference type="GeneID" id="18471639"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33220"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_1_3_1"/>
    <dbReference type="InParanoid" id="I4Y9E7"/>
    <dbReference type="OMA" id="FHFKIAE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="238" mass="26263" checksum="CB1D99BBCE72486A" modified="2012-09-05" version="1">MSLQLPQAGNKPNSMPPPSGPLQRPQPQAAPTPQPFAVPPTPQAVQTPSHTDTGFTHSAGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFDAKFSEFKIQNIVGSCDVKFPIRLEGLAYTHGHFSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYTAFNNIYATLLDYRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H0</accession>
    <name>I4Y9H0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_29529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959400.1">
        <property type="nucleotide sequence ID" value="XM_006959338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H0"/>
    <dbReference type="FunCoup" id="I4Y9H0">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9H0"/>
    <dbReference type="GeneID" id="18471104"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29529"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9H0"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16045" checksum="A425846B6BE17C67" modified="2012-09-05" version="1">MKFSRDVSASRRVNRKAHFAAPSSERRKLMAASLNKELRKEHSIRSLPIRRDDEVLIVRGSNKGKEGKVVQVQRNKFAIYVDRVHREKANGQTAPTPINPSNVVITSLKLDKGRQATITRKADAKKAALEARTQTKDVNMTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA28</accession>
    <name>I4YA28_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_69498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959082.1">
        <property type="nucleotide sequence ID" value="XM_006959020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA28"/>
    <dbReference type="FunCoup" id="I4YA28">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA28"/>
    <dbReference type="GeneID" id="18475591"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69498"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691165_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA28"/>
    <dbReference type="OMA" id="NDAHMCT"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="196"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="399" mass="44827" checksum="FB807BE591BAFBF9" modified="2012-09-05" version="1">MTVLPHRAFYNASRNIKSNSNNNSIKLNSLLNLNSNIYNNNCNHDENQVTATSLHPQQSISTVSLHSLKQPPIHFNSNPYNKQLSLKNYKLSSANLRFCCFGNLLTSKDNPSAFIASVILILGLPAIFFGRVAVDLWFTLSPAVAIIAAYLTLLVWSSMIKTAFSDPGILPVNIDRNSLDTLPKDVTIRDGLVRVKYCDICQLVRPPRASHCRLCNSCIDGIDHHCSFLNICIGRRNYPSFLVFCLVTTVTLIYYAVFAAIHIWQLTKNTRVSDDQSFKQSLQQDPASAVIFLLSIILLIPISLLLAYHTRLVIINSTTIEQLRSKALSKAQKSDTENSQNPFTTDLNGSNRSNFNPFSHKSYISNILWMVFRPGSNYSYVNFNKHAYTDSRKPNSEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA31</accession>
    <name>I4YA31_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959085.1">
        <property type="nucleotide sequence ID" value="XM_006959023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA31"/>
    <dbReference type="FunCoup" id="I4YA31">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA31"/>
    <dbReference type="GeneID" id="18474122"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60721"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="I4YA31"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="497" mass="55728" checksum="931576F40C19846C" modified="2012-09-05" version="1">MSLNTVSVKRQPSSTDFKSATTNVSSRSMRQELDKLVDGVEDPQTKKQFKAEMDGFYNLFNRYLDEKARGEKIQWDKIKPPAAEQVRPYADLPKATDHSILDKLAVLKLNGGLGTTMGCVGPKSIIEVRDGMTFLDLSVRQIEHLNSAYGVNVPFILMNSFNTHEDTKRLIQKYEDHNIQILTFNQSRYPRFGRESLLPTADSFDSQKDNWYPPGHGDIFEALYNSGLLDELIKAGKEYIFVSNVDNLGAVVDLNIYQHMIESKAEYFMEVTDKTKADVKGGTIIDYEGQARLLEVAQVPKEHVEEFKSISKFKIFNTNNLWMNLKAIKRVVEERQLSLEVIINNKALDNGTPVIQLETAVGAAIKHFKGAAGINVPRSRFLPVKSCSDLLLITSDLYSLEHGVLVRNPKRIFDTTPVIKLGDTFKKVANFQGRFKSIPNILELDHLTVSGDVVFGKNVVLKGSVIIVANEGNKIILPDNSVIENKLVTGNLAIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA35</accession>
    <name>I4YA35_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_64989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959089.1">
        <property type="nucleotide sequence ID" value="XM_006959027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA35"/>
    <dbReference type="STRING" id="671144.I4YA35"/>
    <dbReference type="GeneID" id="18474977"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64989"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_2_0_1"/>
    <dbReference type="InParanoid" id="I4YA35"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="573"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="785" mass="88220" checksum="50873E5EA497C4A9" modified="2012-09-05" version="1">MNSHDEHEPLLNEDEIGDQPPPKRISKLNKILLAVIIGLIILLSVSVGLFAGAEVNYKKAQNAKETITVTQSYTPKPTQSPGYNLCTTQSCVNAASEIMDSIDDSVDPCDSFYEYANGGWLETHPIPPSKGVRSIFEDVGNKNTEIVKSIILANVGTEEYSPADKANMRTIKTLYDSCTNTKAQDKKGAEPLLHLTDELISIFNKRYINQKESRQSILTQAAAYLQSKNIGALFSFSLDGDVGKDPSKQVMWLSQDDALSLPDKDYYEDEKNVKFIAEITQEILKAVHERKDSKHHKIPKNSYRKLSREIARFEQYLARISWNQVDSANPIKTYNPKNLTELSETAPYIDWPQYFALLNHNSEVVEPVIVQNPGYFEALDNVLSVDEKTLEGYFILKLVLNLGSTLSPKTHIGKTVNRFNALISGTNPKAEKDIELDCLEAVVDQVGFLAGRPFVLEAFPGESKSKFENIVDGIIDSFIHRLPNLGWLDDKTVKAATNKANVIHKNKKIGYPTSHPNTLDPEDLANYYSINNILEDDWFGNTLRSQEAEAVRMFNKAGKKAEGEWDMIPTEVNAYYQPSKNEIVFPAGILQPPFFKADWPQVLNYGSAGSVAAHELCHAFDHVGRQYEADGRLIFDGSWWSNETVQAFIERAECIVNQYNNFTMPGPRGQELNVNGRFVVGEAIGDLGLVQAYNAWKNAEAEEKSLRLPGVDFTDEQLFFISFARGWARSTRLEENLKRIKTDPHAPPKWRVDGTLRNTPEFAKAFGCKKGSLMNPPDSEQCRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-03-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA61</accession>
    <name>I4YA61_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959114.1">
        <property type="nucleotide sequence ID" value="XM_006959052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA61"/>
    <dbReference type="GeneID" id="18474981"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65013"/>
    <dbReference type="HOGENOM" id="CLU_2028512_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA61"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="122" mass="13232" checksum="3D8701EC0240E51A" modified="2012-09-05" version="1">MSLAYVLVAAQPLSSNSTLDDISFKDILTRSLFSLYGSVNGSFYVDVLAVTQKQSNGLQKVALKCSSKHQQLLENAISMAPTSQTTFLDSAFKLSVLDSANTPSILNTITQSEYIDAQLSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAG3</accession>
    <name>I4YAG3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958948.1">
        <property type="nucleotide sequence ID" value="XM_006958886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAG3"/>
    <dbReference type="FunCoup" id="I4YAG3">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAG3"/>
    <dbReference type="GeneID" id="18474077"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60657"/>
    <dbReference type="eggNOG" id="KOG1107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005836_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAG3"/>
    <dbReference type="OMA" id="YIRSREY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="832" mass="94253" checksum="1C88226B1D2F2E13" modified="2012-09-05" version="1">MDEPKLLTEALNAVKTSQIQMKKCLDADELMDAFKSASSMLSELRTSSLGPKAYYELYIAVFDSLRHLSSYLYDAHLSGKHHLADLYELVQYASNIIPRLYLMITVASVYMSTPDAPIKEIMKDILEMSRGVQHPIRGLFLRHYLSGQTRDYLPISVSDSGNGSLNDSIAFILTNFIEMNKLWVRLQHQGHSRDKERRELERKELRILVGTNLVRLSQLEEIDLATYQSLILPNILEQVVNCRDVIAQDYLMEVVIQVFPDEFQLNTLGPFLAAAAQLNTRVNIKQVVISLIDRLSMYAKRESEMQSTEEIAKQDEETNKKLEDKVKARRSGQEYVSESPTDKKGKGREEDPSKKYRGIPQSVKLFEVFWEQIVNLIETRPDLSIQDITALLVSLASLSLNCYPDKLEYVDQVLSFTKAKLDTIPQHSPQTINNVLALLRAPISSYKSMITLLALPSYLPLMQLQPYQSRKYIAIDICNSLLNNATIIESPNDVRDILELCQVLIKEGSYEDEDIAIEQASLTRLLHLFKSDDKDVQFELLKTARDQLGEGKRRVQFTFPTLITLAIKLSKVLANDDIFKFIHQSIFQLHVLTDHSDECMRLFLLATRTADEAKLKEMTYEFFSEALLLIEEDIISSKYQMQGIASATKTLQKLTIFVSNPDEYQVLANKLVNMSAKLLKKSHQAESLIIASSVFWQAEGGIRNGSSIKAVLERASRIASTLIDPVTTTQIYVDILDAYLMYLDMEVEEISTSVVSDAVQLISGNLDSMEEANKHPISVALRAPSVVDVKLTSANVTSQFKRSIAHIHSKRNYTPKWNEIDVAGPSLRFGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAI1</accession>
    <name>I4YAI1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_64867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958964.1">
        <property type="nucleotide sequence ID" value="XM_006958902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAI1"/>
    <dbReference type="FunCoup" id="I4YAI1">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAI1"/>
    <dbReference type="GeneID" id="18474963"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64867"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="I4YAI1"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="265" mass="29000" checksum="5D6471B91441CAAF" modified="2012-09-05" version="1">MSVLSTQRLQGKNVLVTGASSGIGAATSLLYAKAGANVVLAARRAEKLEEIVKQARELNPRGNYEAVNLDISKREEINQFFQRTSFKAFDILVNNAGLVKGLEEVGSINDDDVDTMFDTNVIGLIKLTQIFVNHFKERNAGHVVNLGSIAGLEPYQRGSIYCSTKHAVRSFTSSLMKELVGTPIRVSEVEPGLVETEFSVVRFRGDKEQADNVYKDLDPLTPEDIAEEIIWITSRPPHVQVANTLVFPTNQASAGIVARPGKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAU5</accession>
    <name>I4YAU5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_29031</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958769.1">
        <property type="nucleotide sequence ID" value="XM_006958707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAU5"/>
    <dbReference type="FunCoup" id="I4YAU5">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAU5"/>
    <dbReference type="GeneID" id="18471071"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29031"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031900_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAU5"/>
    <dbReference type="OMA" id="PIYITPQ"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="245"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="126"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM21087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="315" mass="35239" checksum="6D32F8E6FF8FFBF9" modified="2012-09-05" version="1">MDEAAVVATEFVNSLDNLQQEFQFILTEIRLRDQSSSEIRDNIQRKEVELNTTMLKTKPPGSTTNKEETKPDTDFDNYLKSEYDRLDKLANEKLEWSNKLKMLIDKHVKRVNVDLVTVQQLSANLNAGNAPLNSPATLISNPFNQKAPSTPTPAALNKSLSSNSQKRPSITDKISTPGVSEVTQKKRKLSSLNPSSGNNTSKKSRQSSARPSESEEDQSIDAMEDESISDSTKGGITGEADEDENVYCYCQKKSYGEMIGCDNDDCQFQWFHLGCVNVKPPLPEVWYCTECKNKLGMSSNTPNKKVLQSIQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY3</accession>
    <name>I4YAY3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32858</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958802.1">
        <property type="nucleotide sequence ID" value="XM_006958740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY3"/>
    <dbReference type="STRING" id="671144.I4YAY3"/>
    <dbReference type="GeneID" id="18471573"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32858"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAY3"/>
    <dbReference type="OMA" id="KYLVNCM"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="225"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="946"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127692" checksum="9B0744A285DB7FE2" modified="2012-09-05" version="1">MLDTPRPRSTALQPPKLGTLNQRSNTTIGRSRTLTKNERAPPVTPLVKPGGPSIEMNKGPWHYTALVLTFFVPEPLLKLFVDTPAKRQAWREKVSLCLICAFLAGIVGFICMGVDRVLCPSSQGTMDTQFERVGMKSGTVSIAGKNYVTNQADASDVDFKALGEGSPGIDLTNYFRRPSPDKCSNIESAYATVDTCAKGADCKYDAPTDSVISSLGLSDDHTLAGYSWSNATARRNMMVIDGKVLNLTPYIVRQVHKLDDDPVDKAIRRVLFSDDTSGGKDATKLFYSTKALKDAVPCLTERYLAGYIDHMSPGCFASQLFLYAALIVILGVVFARFIMACLFNWYLAKKFTEPPKNMSRAVVSPSVMPSGANISVNNKQGTAPWASDGAEPKSSKKAAKMAKYRSLVPDDPVISAAQVGTELFTCCLITCYSEGFDSIATTVESISASDYSDQRKLIFIVADGMITGHGEKMSTPDICVSMIEPDPRFGNPMPMAYLAVGNGRKQENRAMVYAGHYKSKNGHRTPTIILVKCGTEDEAANDPKPGNRGKRDSQIVLMNFFSRVTYNDRMTPLDYDLFRKIHTLMGVTPDYFETIFMIDADTKIFPNALTKLVLCMQHDNFIMGVCGETRLENKRATWVTWIQVFEYYISHHMVKAFESVFGGVTCLPGCFSMYRIKARRDQEDDWVPLIVKPEVVEQYSQTDVQTLHQKNLLLLGEDRFLSTLMLRTFPNRKMMFCPAARCRTIAPEEFKVLLSQRRRWINSTVHNLMELVLVRNLCGTFCFSMQFVILMDLIGTVVLPIAILLSLALIINSIITPPNKFADAIPLMMLCAVLGLPAILILVTTRKIVYIGWMVIYIIALPIWNLVLPVYSFWHFDDFSWGETRKVEGEKKSVAHEHKAELFTVNVPLRRWEDWERSRLRKAKREEKTRKEFEKAFGQRGFYNDLSAPDAGLRPDSTDYAESDNTSLSSYGEEDKWGEDIGNYNEFNSSGNPPPASALTPAHDLLLKGGGREYDENAMEELLNEGFDENRPQSVWFLPSRQSIAGNAIPAFIHEQEKNARLSKFKSTIIDSPSTETPDSSTYSVASPFTPSESFEPLAHSSAFETANGQSRHMRQRSGGQTLGPNHSGAPRVSWVDLGPLNEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB04</accession>
    <name>I4YB04_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_69295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958820.1">
        <property type="nucleotide sequence ID" value="XM_006958758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB04"/>
    <dbReference type="FunCoup" id="I4YB04">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB04"/>
    <dbReference type="GeneID" id="18475566"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69295"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034316_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB04"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="318"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="445" mass="48737" checksum="18FFAF3EB05343C0" modified="2012-09-05" version="1">MSQIEDKTQLDLEPNPFDQSFGASDDKDPKLPSISSLTQQQQQQQQQQQQQQNAPPQQNQLGPSQAQLQAQAQAQAQAASAVPTSLRSGPLSPAMLQGPAQQNNPFEASFAQNQHLKTGLTPLPGGQYQPQSPNTAFFQMNMVQPPALTPNTVSAINGVVASFDGNDRPNNGENSDAFQNYRAFQSQENKEALEPPHHQQRYERNSGDAAANAANGLFLLSQASRHEQSSVESPEVDVGQKRKAESLSAPSPPVNRKRGPGATRGRGRRSNAAKREDDYDDDDDDAFEDDDDAMLPPSTRAGSVTRGTDPNKAEMTDDEKRKNFLERNRQAALKCRQRKKAWLQQLQQKVEFLQTDNEALQQTVVALREEIGVLRNVLSQHSGCNVAQAQQTGQSSGAQSAQSQHQSQPSSSMLSPLPIQAQHQQLHPHQAQAQAQHAAAQRAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB37</accession>
    <name>I4YB37_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958852.1">
        <property type="nucleotide sequence ID" value="XM_006958790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB37"/>
    <dbReference type="GeneID" id="18475571"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69327"/>
    <dbReference type="HOGENOM" id="CLU_754796_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB37"/>
    <dbReference type="OMA" id="PHTAKEN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="367" mass="40870" checksum="711ADAC5E324F494" modified="2012-09-05" version="1">MIVTGIAVSLIAILLGFGTIPLMQVLDDRFKFNLGSSFDGLRKTISESNIPIIEAPSSTPIREVNSATFLIDLVRIGYSHARLQKFRIVSALYEHKYDKLAEFVNQITLWQLLMVLAGVWLVTAITFFSCVINSNEEPKSSDKPTENPSEWHLDNKKTEYSNLLVPDNTSAKSNAEAQDNALGLDIDKSELPVQSTITKSELAEPSFVQEDVYQTPQIFLPNENIESDNVSEDKEVNAVDIDDSASIHSSSTLESQKWQEPEDTYKRISSYSTQSQDFEHENLFTKLETEEAPAMETPTKQNETTLPDSNKSQRSQRSQKAKEIVRKVSRTPSKMMKRMSSNGGSGSTSGGLKNANAFTVLDNDVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB65</accession>
    <name>I4YB65_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958879.1">
        <property type="nucleotide sequence ID" value="XM_006958817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB65"/>
    <dbReference type="FunCoup" id="I4YB65">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB65"/>
    <dbReference type="GeneID" id="18474064"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60628"/>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009379_2_1_1"/>
    <dbReference type="InParanoid" id="I4YB65"/>
    <dbReference type="OMA" id="KRRDYTG"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="81964" checksum="DEAB8E3DA341D0BA" modified="2012-09-05" version="1">MRIKIGLKPIQADGPPAEDKEKSAESNYATLKADEQKQRDDESQREKIAKARNKLELNKRLKGKTLADDTGEDDAKKWAKRIKRKQKEAADRIAKQQAELDTNYQQDYNESHLSGLKVAHDIEDFAEGKEHVLTLKDTSVLDDGDDELQNLDLAEDERGKERAELRKGVKAHQYTGLDDDEFTTDGDAKKPSLLSKYDDDLNGSSESGFRLGDAIAPTKPKVEEDNALTQGEEKVNKTMLSLDYLKNQEASDFLKEGDVGFKKPKTKKKKKSSRKIEIKEEEDQDMEVDVKPPPPRERANLEHSNFIDDDDLQIALAKQRREKLKKKSARQRKPEDIAAEIKNLEEFDKHDDKAKEGGLEFDDTSEFIRTVQLAPQQEAFESKVKSEPLSEIDLAPPTAEVGEDMDVVVEDVDGIRQQQEQDEETVERAKSESPSVPSEMAQPQPGKGLGGILASLKQQGQIETLTPEQREKERVQQNNTKFLAEQRMKEIIREEEKLRIRNDHTKTQAQRDFENRQRDAKSAQEDKEAFERNYKPSVDIKYFDETGRSQSTKEAWKYLNYKFHGKGQGTKGREKALRKVENERKQLAMTSGETPLNMMSSFQARQEATGSAHMVLSVGNRGAAPQADTLYDPDAGLSKGKKRAESADRGDYQRGSSTGVASVESSAGPAPPVRQGTSSFVPISGTASGTLTSETEKRTKSSFAPIGNGTTSSGGTQSNEQGGLKLGAKISFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB95</accession>
    <name>I4YB95_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_64505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958592.1">
        <property type="nucleotide sequence ID" value="XM_006958530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB95"/>
    <dbReference type="STRING" id="671144.I4YB95"/>
    <dbReference type="GeneID" id="18474934"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64505"/>
    <dbReference type="HOGENOM" id="CLU_491088_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB95"/>
    <dbReference type="OrthoDB" id="2281547at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="8">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="555" mass="62357" checksum="A86DE628C7AF7442" modified="2012-09-05" version="1">MTDAFSLYFDILNKNTAYNKHSDVELLIRLKNLMVDMDDSDKVGKYREVHSFLKNHHNQVKATTNDTLQASAIHSLLERRSTYQTPYVRDNTENRSTSSMMSRIEATAKEFGLEAFQDQSQQADVTVHTVTIAGTILVIDVDLTSTQSNTSLTRLKTTYATNSSINLEPVDNLLIRDLDGYVSLEPNSSDPESAALQSERHFINFKRNLQQLVVLDKLSQSIGNQTDLFVNFEILSKAFADLSVIENAATSEVKHLHLYPSLDINGHGFSLLHTPRPYLTQVLHVSSQHLLDPDEALRSISLQDTYSIHLELRENGFPFKQTFPSKVQPYLKAQLPFNTNIQPLPGNVDRITAYAVLNKSLYLPKSACIAIQAALGYSDNVSDQQIVKLTWLDCIYQRELQKPIGLVSQSVANFKRQIYRFNNPENDQTIIKLSAIPFKSFSDLLRIIEILKTHLFIDELITSCLRNSSEAETINDGLEIALSLNTESLSIEVIVGSTNCTIAVEQNDLAILSNTLDEGMKVGFSQVIRKTRNLPIALSWLTKKLDGGNDTMQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBA5</accession>
    <name>I4YBA5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">WALSEDRAFT_28892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958602.1">
        <property type="nucleotide sequence ID" value="XM_006958540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBA5"/>
    <dbReference type="STRING" id="671144.I4YBA5"/>
    <dbReference type="GeneID" id="18471064"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28892"/>
    <dbReference type="eggNOG" id="ENOG502RSAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBA5"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="170" mass="19096" checksum="78323435021BBB8F" modified="2012-09-05" version="1">MMLRTIIASRGICTSARLNNSIKECLRDGLKQSMKSKDSNTSTVIRSLLSEIAYSEKETPDLDENKTIKLVQKAIIRRKESAEQYLQAKRQDLADKENFDISVLEKYIPKPFTQEEMVELINNILNDAKLNVSELDGRAMGQVIKDFTAKAAGRASGGDASKLIKQMQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBA8</accession>
    <name>I4YBA8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_9587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958575.1">
        <property type="nucleotide sequence ID" value="XM_006958513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBA8"/>
    <dbReference type="FunCoup" id="I4YBA8">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBA8"/>
    <dbReference type="GeneID" id="18475849"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9587"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_1_1"/>
    <dbReference type="InParanoid" id="I4YBA8"/>
    <dbReference type="OMA" id="FWYTVSS"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698744" evidence="6">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="341" mass="38386" checksum="EC1F7597D0ECE1DE" modified="2012-09-05" version="1" fragment="single">HVKFIILCLCWYLSSALSSNTGKVILSHHRLPVSLTLYQFGFISLFTYIITQRPFNLTKLKTFDKHVFKSVSPMALFQIGGHVLTSMAISRVPVSTVHTIKALSPLFTVLSYKFLFRVNYSTQTYLSLLPLTLGVMLAMSFDMSLLNTGGLIYAFLSTFVFVSQNIFCKKLLPSETQKLSSQKLDKLNLLFYSSLMAFTSMIPLWFYSDFGHIWNLIFVGTSVERPVGFSLYILSNGFVHFAQNLVAFAILAATSPVTYSIASLTKRIAVICLAIVYFKQSIHFIQMVGIVLTGVGLYLYNKSKQDVNKGEIKVRRDEALRDYALPTTKSEEKFLSGKDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBK2</accession>
    <name>I4YBK2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958692.1">
        <property type="nucleotide sequence ID" value="XM_006958630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBK2"/>
    <dbReference type="FunCoup" id="I4YBK2">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBK2"/>
    <dbReference type="GeneID" id="18474011"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60538"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="InParanoid" id="I4YBK2"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
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        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="149"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="218" mass="24263" checksum="8DABA726B5FE1818" modified="2012-09-05" version="1">MQSLKLLKRNLRKSTLKKLSEISNEAISLQSRAVKEEICASDIYKRSTRISLYLSMQSSELSTDDLARQIIDDGKKLFVPFIHTNEVPTMSMLNIPTVEQLQALKRNKWGIPEPDAADVDKYQDALSSESPGLDLILVPAVAYDKSFNRLGHGMGYYDRFIKAATTHAEGYALHPPTIVGLALQEQIQTQDSVPTGPLDEVMDAIATSDGITWNKQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBK4</accession>
    <name>I4YBK4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_32792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958694.1">
        <property type="nucleotide sequence ID" value="XM_006958632.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YBK4">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBK4"/>
    <dbReference type="GeneID" id="18471560"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32792"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_2_2_1"/>
    <dbReference type="InParanoid" id="I4YBK4"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="388"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1416"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1492"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1746" mass="195376" checksum="513790FB74249799" modified="2012-09-05" version="1">MDIAHPISSKPKSVSFGFLTTDEIKKISVKQIVNPSLLDNTGRPTVGGLYDPALGPSDRGDICATCGLTSFNCPGHFGHIELPTVNYHPLFFTHCFNMLRGVCLYCHHFKLDPAVVTRYVAKLSLLDYGLIDEAEQVDLIKRGVSEAEEEDATSKMSKSALKALEKERELEAYKSRVNSWVKFNVSKAQQNGKTRDEYKSGLVYQTRKRLFHQLFRQMYRKKCDNCNAHAHAFRKEGSIKIIEYSLTPKQEAQHNALGLSRPDVLKEQAVVDKNAREALKKQTQVSKDSDSSSEDEDDGEDTQSNNGDITMNDSNDTNGDVNIDDEEDIAAIKANNKNNAALLKRSERVVPASEVQAHLHRLFTNEKELTSMIFSRHGPFPTNEAMADIFFMSAIPVPPTRFRPAARMGDALMEHPQNELLGAVLQTSLRIRDYNNEMSALNDKDYAQTMAANSSLGENGIKIIRDRTYQRLLEELITLQHGINSFIDSSKNPARLPQGREPTPGVKQVLEKKEGLFRKHMMGKRVNYAARSVISPDVNIETSEIGVPPVFAKTLTYPEPVTPFNVSYLRKLVINGPKNYPGASMIQYEDGRMESLEKKSQEQRTAIANQLLTPSNRPDNQNKMTTRTSSINKKVFRHLRDGDVLLLNRQPTLHKPSMMAHKAKVLHGERTIRMHYANCKSYNADFDGDEMNMHFAQSAIAKAEMMFIANNDNQYLVPTSGKPLRGLIQDHVVAGSWMTMKSTFFTRDEYQQLLYGALRPENDYTGEGRVHLLPPAIWKPQPLWTGKQIISTVLKNITPSNARGLNLESESKVKAEYLPAWGSNENKVIIVDGVVCSGIIDSSQFGTSSYGLVHSVFELYGSECAGKLLSILSRLFTKYLQHRGFTCRMDDLILTDEGNEVRDEILEGTKNYGFEAAIDSIGLTEEQSKGSEGKRNVLMRLEEVLRDDNKLAMLDQTSTSKNEQIKSQILKKTLPAGLWRRFPTNHFQAMVLTGSKGSAVNASQISCLLGQQSLEGRRVPVMVSGKTLPCFKPFETDMRAGGFVAQRFLTGIRPQEYYFHCMAGREGLIDTAVKTANSGYLQRCLIKHLEGIKVHYDHTVRDSDNSVIQFQYGEDALDVTKQVYLNKYKFAVNNYDSMMRKYNPKALIGKVDEEAAEAYMKKALKKPYKYAPVLSEYSPSVYLGATSEKFAKDVDAYAENNPDGLLIPQSSKKNKLSDAEIEALVKKLKQQGGAIAKPKQFKNLLKTIYARSLVEPGEAVGLLASQGVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASAQIKTPTMKLPVFEHITEEEMKVFCKNLNKLTLAECVDDVRVIESLSSKTPENGFSRRKTYKVHLNLYDPNEYSKEYNVEPYDVCYAMKKFTAILDKEITIELRKVTREQTGSAANIGRGQRLREKPGENENNGDEDAPVKDAQKDDDNEGDEGDAESRKRIEKTKEIASYSDDEASDEEDQKKDDDNADDSDKESDIQDDDERHRKHSKKLGEKLSELEDKIVQDSHYMTKLDCDREGGYVEFELEFSSKALKMLLVGIIEKACRKTVVHEVPGISRAILLDKEKNKDGSVKKQRSIQTEGANLMGIRSFGQDFIDLNQLYSNDIDAIRRTYGVEAARASIINEVAGIFQVYGIGVDFRHLALLADYMTYDGGYKPFNRTGLSGSPSPLLRASFETTASIIAEAALFGDFDDMKSPASSIVMGCVPEVGTGLFNVGVANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS3</accession>
    <name>I4YBS3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="6" type="ORF">WALSEDRAFT_60416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958446.1">
        <property type="nucleotide sequence ID" value="XM_006958384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS3"/>
    <dbReference type="STRING" id="671144.I4YBS3"/>
    <dbReference type="GeneID" id="18473934"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60416"/>
    <dbReference type="eggNOG" id="KOG3846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="InParanoid" id="I4YBS3"/>
    <dbReference type="OMA" id="LPGWNSH"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="447" mass="50867" checksum="3B66BBC82D97DCDF" modified="2012-09-05" version="1">MSVTIDYFKGIEDIKDEKHYKLLDDLDSLSNFKNEFHTPAKDDGQIIYLCGNSLGLMPKRTQNLLIEELDVWKSHAVQGHFDHPHNRPWKSCDELVKPSLGRLVGAKPDEVVAMGQLTSNLHKLLISFYKPTEKRYKIVYEDNAFPSDNYALQSHARLHNINPDDALVRVKPRAGESTLRTQDILQTLDEHDDSIALVMFSGVQFYTGQFFDIGHITSHAKSKGAVVGWDLAHAVGNVPLKLHEWGVDFAVWCSYKYLNSSPGGIAGIFIHELLTQTHIQVDHKRMEGWWGHDPETRFEMGPHFTPSTGASAWMVSNTPVLTLTALYASLQIFDEAGIDNLRAKSIMLTGYMERLLKSSNHYTDNDQLDHKQFTIITPSNVDERGAQLSLKFNKDYMLFYNEQLQLNGVIGDDRKPEVIRLAPIPLYNSFKEVYDAVSILERIMDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBU1</accession>
    <name>I4YBU1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958463.1">
        <property type="nucleotide sequence ID" value="XM_006958401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBU1"/>
    <dbReference type="GeneID" id="18472922"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57512"/>
    <dbReference type="HOGENOM" id="CLU_1176210_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBU1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="236" mass="27663" checksum="302E78DF722AED8E" modified="2012-09-05" version="1">MKGIASHNAPTFDSFNMERIHHATLKRFSQFLVDFVNDTSKSKHIIQLRYKHYGNTTSVELQTLKALLKLPNLERLVYQTDKASCINTLARLCDPSLNRHLRQINIKVRTIPDLALYLNRLLQLPHLSLLTIDTTFNNMSVIKHQVYNLIGLFDLFQPNPDVKVITRFIHSSNCVHNNLDYDIDNYVIIWKKCVVCLDHFTIIRSFDSFNEILAKAYQWPDDSHYIREKLLEIHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ9</accession>
    <name>I4YBZ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60464</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958520.1">
        <property type="nucleotide sequence ID" value="XM_006958458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBZ9"/>
    <dbReference type="FunCoup" id="I4YBZ9">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBZ9"/>
    <dbReference type="GeneID" id="18473962"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60464"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="InParanoid" id="I4YBZ9"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="192"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="276"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="454" mass="52159" checksum="08B48DF1FD39851A" modified="2012-09-05" version="1">MIDLVLLQEAKGGNPELVKESQKKRYASVELVDEVLKLYQDWTSISYESQQLNTQINQTQKAITAKKKNKESADDELAKKKELDSKVAGIKQQALVAEQAMKAKAVTIGNIVHTAVPIDDNEDNNVILRLWHPEGPNAQVEKKEGILAHHEVLQRLDGFDLERGQKIAGHRGYFLQDTAVDLNLALISYGLDFLRKRQFKKVMTPFMMRKDMMSKTAQLEQFDEELYKIEDVGGEDDKYLIATSEQPISAMFANEWFEKPQDQLPIRMAGYSTCFRKEAGKHGKDTWGIFRVHQFEKIEQFCVTSPEKSWEMFDEMVNNSEEFYQSLGIPYRLVNIVSGALNNAAAQKYDLEAWFPYLGEWKELVSTSNCTDYQSRSLEVRHGIKKQGETNKTYVHMLNGTMCATERAMCCLVENWQNEEGLVVPPVLRKYMDDREFIPFVKELPKTKANKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCA9</accession>
    <name>I4YCA9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_13022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958233.1">
        <property type="nucleotide sequence ID" value="XM_006958171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCA9"/>
    <dbReference type="STRING" id="671144.I4YCA9"/>
    <dbReference type="GeneID" id="18470607"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13022"/>
    <dbReference type="eggNOG" id="ENOG502S1HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040321_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCA9"/>
    <dbReference type="OMA" id="WPECEGL"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="22029" checksum="16ED393284C344B5" modified="2012-09-05" version="1" fragment="single">GPFALGVQALMGVIVLGALVFKRYREPYRRPWKIWYALCDVSKQIIGQAFVHGFNLLVSDFFAVHGGENPCSGYFLNITIDTTIGVLIIYGFMKLFHWLLVTKLHNERFRSGHYGKPPSIISWLLQLVVYVLILTLMKLLVAVSLAILPLFSISDFLLDEISPNAQVIISMCIWPLIMNVLQFWLIDSLIKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD4</accession>
    <name>I4YCD4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958321.1">
        <property type="nucleotide sequence ID" value="XM_006958259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD4"/>
    <dbReference type="GeneID" id="18475484"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68892"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_6_1_1"/>
    <dbReference type="InParanoid" id="I4YCD4"/>
    <dbReference type="OMA" id="QLMKFRQ"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="112"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="421" mass="47236" checksum="4A569E798AB544B9" modified="2012-09-05" version="1">MLNRFTSYIKYEGSIKRAFHSNSRIAKNATDLPKPKPKAILRRTAAEQSAPVRSKLVYSPGRSDVMPVNAFSTAERYDFAALAAGLKSFNSYLVPDTDGAIYIPLENGKKEVFVFRSGSFVTWGMDSSQGERFLRQVIRRGNSVSTNSLQKVLVASGRWKWTGKNEDNGTAGWVEKNRYLDYETEQLDYVIDPSESTRLQGDLIVLGKEAELNTSLSTSIQSLTPTGAQLQDTIYPVLLSKYAFSHALSRSAKLSALESQLSTYLSKVSSIPAYLALNGHIPPEMDRKAIASSMGELLRFRQGLNLELDNEGENFWGVPDVLWDEQVLESYFQQVSEVLDIKPRVDAVNQKITYAADVQATLRDYLQTQTSHRMELIIIALITVEVALAIITHGREIYLVMTESEDDQNMKEEHQTEKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCH8</accession>
    <name>I4YCH8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_11010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958232.1">
        <property type="nucleotide sequence ID" value="XM_006958170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCH8"/>
    <dbReference type="STRING" id="671144.I4YCH8"/>
    <dbReference type="GeneID" id="18470587"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_11010"/>
    <dbReference type="HOGENOM" id="CLU_2910617_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCH8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="62" mass="7130" checksum="1265BF8C606367F5" modified="2012-09-05" version="1" fragment="single">SKENIASRAYITFKEYAQLLSFHAGFDGHLESRASIEFAPYQRTPQPKQKQDQRQGTIEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCI1</accession>
    <name>I4YCI1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958360.1">
        <property type="nucleotide sequence ID" value="XM_006958298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCI1"/>
    <dbReference type="GeneID" id="18474913"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64293"/>
    <dbReference type="HOGENOM" id="CLU_1338459_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCI1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="24378" checksum="F3837D6C25168197" modified="2012-09-05" version="1">MHKIINLEHIIKKSQQELDSLKSSISNTHTKIKTQTQTSSTKSRSQRPINPPSLPTASRRPSAREINDYNSVYLMQTGQAQPVHPIENAYYVQQQHEKYRKYQEYQQYLQYQRYQQYGDNQRYPYGYTYGNQQQRYPSQYPTHPLQYHSQYSYNTQAHPKKIQPSPFDHCTSEDIDKLVAEGKTTWEEVDEIDRRCWINLPPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ0</accession>
    <name>I4YCJ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoporin protein Ndc1-Nup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958369.1">
        <property type="nucleotide sequence ID" value="XM_006958307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ0"/>
    <dbReference type="STRING" id="671144.I4YCJ0"/>
    <dbReference type="GeneID" id="18473918"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60373"/>
    <dbReference type="eggNOG" id="ENOG502S8WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452136_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCJ0"/>
    <dbReference type="OMA" id="WQTANLF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68182" checksum="A1B1794A4B4B0C17" modified="2012-09-05" version="1">MQARPASKLTIRKPDSGVSNTTYATLCKLVLRKRMSRVLVLSLVSKIAIFALSTSNVRDGFSIILSPFGLQRILFALLAFILADIPVIITRKLALLSSFFYVNNAYSLTKQSAKSQPAPVGPSKHLKALLLDQKTYNLAVTYAFSAIAYGAVYISCLSAYEDEAGFTPFTSHIRRGWQFNERFIFLFLNAALLGAVYALRQLWNDRFVTRFPSNLSSSISSRAQSHLKRNVPMAMKFALIVVLTVLSSYLLTKKSIYRTVASLSLATFRPHLFTLLRQNNVTFGLVLRTTVFALGLVSSWEVTNTLFDIYSVHPIIISKIAPNPTDCLISGMQSTDFYYKYFAYLEFVKVFSSSQERRQEVYKDIHRKPSSWDKILSVAVQELVEGRTKVLTKGVPTNKTPTVVNSTPDATTSSSKLRVVDNQEIFKRNPKSTVDNFIADVQVDKKASMFSKQTENVPADQGIGFDKILSPEIVKTLKNSIYGNEESNVNAKIRLLAPDIKLVSLCSLGLAYLGAASIQEDEFGLIQHNIPQVIHEVTSTLLTYEELQIDLEKLTKNSNHLKEYSTRVQEIQNALSILLFAFKDYVKSFNLDEKTQKRVELAIKEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP5</accession>
    <name>I4YCP5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_68673</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958048.1">
        <property type="nucleotide sequence ID" value="XM_006957986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP5"/>
    <dbReference type="FunCoup" id="I4YCP5">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCP5"/>
    <dbReference type="GeneID" id="18475450"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68673"/>
    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="InParanoid" id="I4YCP5"/>
    <dbReference type="OMA" id="IPFRAEC"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="117"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="529" mass="57629" checksum="615D336A3A1B9E7C" modified="2012-09-05" version="1">MYNELEGIAHYLQQLPGSSIFIRYVKSSYQNDPWRSLLELLLFLFALRVWLSKRTRRDAEKGFVGLSSTEIDELVDDWQPEPLVPQAEIKQAPTIIGPPSIKPKVSQPGQPSDKARQVTNLVSYNFLGLLGDQRIKDAATKALRVYGVGSCGPPGFYGTMDVHIDLEKSIAQTLGTESAIIYSQGFATITSVIPTFAKRGDIIVADEGCSFAIRKGLQISRSTVRWYKHNDMNSLETVLDSINREAKRRKAPLTRKFICSEGIFQNDGSLANLKRIIELKKKYKYRLILEESYSFGVVGNTGRGMTELYDIPAKEVDILVGSMANTLGSAGGFCAGESVVVEHQRINSAAFIFSASLPPMLAVSANETLSILNSSSGPNIVHSLQTNIASFRSVLSTIDSIELASHALSPIQHVFFSQSKELQIISTSQKEKSSEEERVEAVLGDICDDALVNGVFITVAGHLRGQESDIGALSAGSTGIRVAPGGAPPPTEPRASIKIAISSALSKKETEKAALVVKNSINRVLKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV8</accession>
    <name>I4YCV8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958104.1">
        <property type="nucleotide sequence ID" value="XM_006958042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV8"/>
    <dbReference type="FunCoup" id="I4YCV8">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCV8"/>
    <dbReference type="GeneID" id="18473838"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60252"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_9_0_1"/>
    <dbReference type="InParanoid" id="I4YCV8"/>
    <dbReference type="OMA" id="STHQHHE"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="249"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="423" mass="46759" checksum="CD8DA5912130BB00" modified="2012-09-05" version="1">MTASSSGDTPSALADLVTQVSPSSQPARNTRQPVRKTKKKKQQQTNDTQSPSTSNQDQQNMDSTENPPQTSDQNEQLAAVKEEAPRTTKPSSTKGQRKKKSFFSSFFSSIVPCVGESSKKPAHDVSAKEDEQPKKHRDQQPSTSRRKSKERVEDEIPPPTPVIPNQGVDLPISDTAGLTSGAVMPPGKELSPPTPSRQPSSQMHEESSEEEEIDDYDAELADEERIIAKGGMGIPIGEDGQPKPLLPQLNENSKCLVLDLDETLVHSSFKLIQQADYVVPVEIESQTHNVYVIKRPGVDAFLKKMGEIYEIVVFTASLSKYADPVLDMLDINKVVKHRLFRESCYNHKGNYVKDLSQLGRSIDDTIIIDNSPASYVFHPNNAVPISSWFNDPHDTELTDLCPFLADLTEVDDVRDVLNGSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCZ2</accession>
    <name>I4YCZ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_37931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958136.1">
        <property type="nucleotide sequence ID" value="XM_006958074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCZ2"/>
    <dbReference type="FunCoup" id="I4YCZ2">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCZ2"/>
    <dbReference type="GeneID" id="18472035"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37931"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_1_1"/>
    <dbReference type="InParanoid" id="I4YCZ2"/>
    <dbReference type="OMA" id="IDGPFKY"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="48"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="190" mass="21551" checksum="3EB6A934BA730EBC" modified="2012-09-05" version="1">MISAKRCTNLSRKNVSTIQTRSLFGGFGLPDFSTGNENEFYKESKVLPYAQRDLYNLVANVNEYKHFVPYCTHSRILTKGPIDLQKSGAVEAELGVGFQGFEERYNSIVTLDPYKSVTVCFHILFHTPLFKTLQTKYTFTPKAQHTELAIELEYAFANPLYATLSSTFFSGVSAQMVKAFEERAKIICNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD10</accession>
    <name>I4YD10_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_37960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958154.1">
        <property type="nucleotide sequence ID" value="XM_006958092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD10"/>
    <dbReference type="FunCoup" id="I4YD10">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD10"/>
    <dbReference type="GeneID" id="18472039"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37960"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_1_1_1"/>
    <dbReference type="InParanoid" id="I4YD10"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="88" mass="10342" checksum="0E895EF94CD0260F" modified="2012-09-05" version="1">MIIPVRCFSCGKVVGDKWEAYLDLLQADITEGDAMDKLGLRRYCCRRMILTHVDLIEKLLNYNCKVYRIHWDTANVSNSIAHERLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD44</accession>
    <name>I4YD44_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958187.1">
        <property type="nucleotide sequence ID" value="XM_006958125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD44"/>
    <dbReference type="FunCoup" id="I4YD44">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD44"/>
    <dbReference type="GeneID" id="18473865"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60286"/>
    <dbReference type="eggNOG" id="KOG2071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015606_2_0_1"/>
    <dbReference type="InParanoid" id="I4YD44"/>
    <dbReference type="OMA" id="ARSDFAN"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="541" mass="60016" checksum="F9978A1E07351D32" modified="2012-09-05" version="1">MDVYSFYKQQLGTLNSNQKHLITNLTLLAQQYGSAANQVADAIHDHITCLKPHYRLPVLYLIDSISKNLSQLNYAQHFAPFIAKDWLNTYALVDGATRSKLEELVITWRNGGPYGSNLFGRQAQLDCEQRLYGQGGWKASIPLSYGPSRTLVITELQAALEKRKVHVQYYPYDEKAKSHIHALSTLEKILLTTNVPPDQLNQIYERVKSMSNDAPAGATPVVASTPSVPPPLPTPAIISTPAPAVQPAAPIPVVAAQLNPLLQSNTPPPPPPQPQPQQPQVGSNVSGLLQSLQASGLLKTVNAGNSASTVTSKSKSPQPEQIMAIDSQEDEEKEKAYDQAVLALDIVLDNNDILCPRPNLDKLFYDRLTVQCPQCSRRFADTSTGKKQLAEHIDTHFRINRRNKEGSRGVTRSWLIVLKDWMNDVADDSVASQRGPIQSHEDNEQTQQAEYKKQLESMTVPVPADAEDAAKVCPICKEKFKGEFSEEDEEWVWKNALEDGETIYHATCHNDSFANNSVLGKREREDEVPLDNKKIAIDQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDG7</accession>
    <name>I4YDG7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">ITPase</shortName>
            <shortName evidence="10">Inosine triphosphatase</shortName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957818.1">
        <property type="nucleotide sequence ID" value="XM_006957756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDG7"/>
    <dbReference type="FunCoup" id="I4YDG7">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDG7"/>
    <dbReference type="GeneID" id="18473758"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60127"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDG7"/>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="20583" checksum="68BD0510014865C4" modified="2012-09-05" version="1">MKTITFVTGNANKLKEVKEILNAPLLNKSLDLPELQGNSTQEIAKQKCKIARDTIKGPVMVEDTALCFEALNNLPGPYIKWFLESIGHDGLNKMLVGFNNTRAHALCTFAYADEQTTEPIVFEGRTFGNIVQPRGPTNFGWDPIFQPDEGNGLTYAEMAKEDKNKISHRFRALDALREHLNSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDH3</accession>
    <name>I4YDH3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_28278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957823.1">
        <property type="nucleotide sequence ID" value="XM_006957761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDH3"/>
    <dbReference type="GeneID" id="18471032"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28278"/>
    <dbReference type="eggNOG" id="ENOG502SCF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621433_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDH3"/>
    <dbReference type="OMA" id="SDWEAHW"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="441" mass="50088" checksum="870ACE99BD9B82AF" modified="2012-09-05" version="1">MEVNLRNELKNWEKDFTLKHQRKPVKDDIKKDPTIAQKYKTYSKVKKGANDKDDTATTKSIPPPASTPKKKAAAVFKTPTKPATSSGFTPKKVEYAAASPQKFKDMLNTLSPAKSNNNAKFWTPRTKARKRLRGENVPNTPKKQRMEMIGIQEEQDVVQETKEEEEEEEDDMMNTPAKNKAFKPLFESPRPSTNTSNNSSVVVLPPLPTNTISTYVDNPQSQELTSSQATIPQSQPSQSQRGLKRGQSPENTSRAAISKKKSRTTLKYPNKVELPQSQTLAGKQDIKNEPTQLELEGTSQQISIIPHLQKRKLKKRDEESDDTDIEDYIPMTHKHTERSFIQEDEEAINQDNKVKSRLGELSLDSPGAVKRSKEYNKHIDEKVRSLLSRSDEPGYGNYRTEIMPYDELSSEEGDDDDWEEDCDGWKADGVGFIEDYDYDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDK0</accession>
    <name>I4YDK0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957847.1">
        <property type="nucleotide sequence ID" value="XM_006957785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDK0"/>
    <dbReference type="FunCoup" id="I4YDK0">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDK0"/>
    <dbReference type="GeneID" id="18473770"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60145"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002774_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDK0"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="2">
        <location>
            <begin position="693"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="890" mass="99916" checksum="6833185035E8455F" modified="2012-09-05" version="1">MPTTKRQRVDKAIKPKIFQPFRLLGKISNSKPFNLVTRLTRDANKFNGQIITCLEKSWMMFDLISLRLLFISNDLEFPIESIVNDGNFIYCSSNDSIYKYKRGKLVDQLKSPYKLSKLLLFGSQLLSLKSDGSALLVWDLQSSELLHEIEFGVNFTATDFLHPSTYLNKLLVASKNGQLQLWNIRTRTLIREFNFDSPITTLQQSPAIDIVAVGCENGRTILFDLKSDTELFKVRMDGNVQITSISFRTDGEHIMATAASNGFIAFWDLNQGGNLVNVLRDAHSEPPSKIEFLPNQPILISSSGDNSLKQWLFDSPSSLPRLLKFRAGHTAPPHRINYYGEDGKTILSASKDNSLRYMSVVRDSRSFELSQGSLSRKAAQLALPIAALRLPPITSLSYATQRSKDWDDVLTCHEDSSDAYTWYVQDKKLGAHKLHLDDGIAVSANVSVCGNYGFVGSDMGTVHQFNMQSGIKRRVMTIQNKYQDKDALKISSIVTDALNTTLVCSTADGFLYFFDFHNGALLDSMQLTAGVQQLILQRDNGIMAAICSDNVIRLVDIESRRLVREFKGFTEKISDITFSPDSKWLVASSFDCIIRTYDIPTGSLVDAFRVATIPTSLTFSPTGDFLATTHIDSVGIYLWANKTQLVEVALKPIKFDDVIEVNMPTMQGEVEDEELALMESAPILPTFVESTKEQLESGLVTLSAMPRSRWTTLLNLDTIKERNKPIEAPKAPEKAPFFLPSLSDGLNNNMEVDSKNETHRLTQGSLGIETQLSKILQSEDSNRLEKLFKYLHRISPANNDSDVRSLLPSDLSLFIVALTDRLRQQKDFDTIQANLGLMLRVHADILASDKLLREKLAILSKAQRSECQRIFDMTRYSLGVLSFVRDIPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDK2</accession>
    <name>I4YDK2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957849.1">
        <property type="nucleotide sequence ID" value="XM_006957787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDK2"/>
    <dbReference type="FunCoup" id="I4YDK2">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDK2"/>
    <dbReference type="GeneID" id="18471444"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32227"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDK2"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="236" mass="26034" checksum="89CD5105F813E56F" modified="2012-09-05" version="1">MVQQRSRPIARNVGRLTRTQLYTKRGLFKGQKKAAAPAKEATEEFKTKKVGGAKNGGERKVPTVKARAFYPAEDVAIPKNSRKTQRPTKLRESITPGTVLILLAGRFRGKRVVFLKQLDSGLLLVTGPFKVNGVPLRRVNQAYVIATSTKINVGAVDSSKVNDAFFAKAAVKNASKEEAFFGDKAEKKEYPAEKAQEQKNVDKAILAEIKKVDGLTKYLNASFGLSRGEFPHELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP4</accession>
    <name>I4YDP4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957890.1">
        <property type="nucleotide sequence ID" value="XM_006957828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP4"/>
    <dbReference type="STRING" id="671144.I4YDP4"/>
    <dbReference type="GeneID" id="18471446"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32245"/>
    <dbReference type="eggNOG" id="ENOG502S4SP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048757_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDP4"/>
    <dbReference type="OMA" id="YGFHASI"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF105">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="38864" checksum="227E7E61171E00C7" modified="2012-09-05" version="1">MIVIYNPNSGGKLAEEYLHQHIIPSLESSNISYELLRTEYEGHAQEISSKLARNGGELVVSLLGGDSTTHEFITGLSDLDNPPKTTLVLVPTGTANALYHSIHSSSTLDKDSIEYKLLSFNSFVSKSNNAKRLALSDVIVDDGSSRKTAHVVVSTAVHAALLHRSEELRSVDTSIERFKTAFMEVCTKWTEGRLNLYASRVFSEGAFSDKVEDITLSGPFTYLLASHIDRLEEKFVIAPHNTTEEGLSVVIVRPTRDPLVREHLEKKDYDAATQTSAKVLTDVMYAAYDNGNHLNLKHSNSEFVVEYYHVKSMSFEAENPGNYVCVDGNLVELKNKYTVDSSPVDIFVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR0</accession>
    <name>I4YDR0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957904.1">
        <property type="nucleotide sequence ID" value="XM_006957842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR0"/>
    <dbReference type="STRING" id="671144.I4YDR0"/>
    <dbReference type="GeneID" id="18473786"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60167"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410608_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDR0"/>
    <dbReference type="OMA" id="HPEREAH"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="308"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="553" mass="61207" checksum="807C26F38429BB84" modified="2012-09-05" version="1">MWSVTKESISPPTRPRTSSKRNAVMFEPKSTIIPSSPASSSSATSHNHSMSLDNPQDSSFDSSFSSTQRPRAPSEPSKSDYYYHNPSPARVKKPRLSPLKPPFMSIKTLGRAYSAPGNYVGESKTISGGFSPYQSQSPFLNSNSKYKSAPIRERRQNKKNRLPMPSFDQQSPSLFNDEQSENQPEPSNTFIKPAPFRRAFSLVAPNPMANMPSPGLDSSPCADASPSIRPLSQQIQKPANPIRPSGPLRALSALQGPTVSPRGVQIPGFGHSEKEGKLLPCFSVKDDGLMRIQPETLDKLISEPLPESISDVHIVDCRFPFEYHGGHLPGAVNLGTLQSVENYFLIPNAGANRDTKSLPTPSTSASSNESRKVIIFHCEFSNMRAPTLAKHLRSLDRSRNEHPNLNFPELYILSGGYAEYFRQFHNVKPELKYTPMDAPHFHPQREAHLAAFRASSKPSSIGCLNMGLRSKSFTFATNNSRLTNVSKLLQDQTVTEESDTSMEASPCGNNNMLRPSLLNRTKSLAKLQSSPLTLDFDEKENNLSRDLTFVERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE15</accession>
    <name>I4YE15_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_32317</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958002.1">
        <property type="nucleotide sequence ID" value="XM_006957940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE15"/>
    <dbReference type="FunCoup" id="I4YE15">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE15"/>
    <dbReference type="GeneID" id="18471462"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32317"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE15"/>
    <dbReference type="OMA" id="PLKMGYV"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="161"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="734"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM22207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="839" mass="94977" checksum="6A9CA8EF7ED29440" modified="2012-09-05" version="1">MRFVHARSISFSSFPRFIGRALRVPIAGVTVGGGTFAYANYKFEELRNKTAGVFGDITDGLFDAWSNVQDTLPTSETIGERKERFREWLSTFNKQTENDNDNNNDNDKDIAKSIIASVAVGASLDSNDNNNNNQQPNLLMNLTRKLIEIRSILLSIDQTDNLKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLIHTPDSNKEYGEFPSLSSYGKLEDFGAIQKILTDLNLSVPSSECVSDKPIDLRIYSPHVPDLTLIDLPGYVQIAGLDQPDNLREQISNLCEKYIKTPNIILAVCAADVDLANSPALRASRRVDPLGLRTVGVITKMDMVTPNEGSAILSNKRYPLHLGYVGVVCKAPKRGIIDRLSDNDPNMTGAIMKREENYFQNNKELFNKPGLLIGTDTLRKKLMEVLENSMSSCLNNITNAVQIEQEEAAYQFKVQYNDRRVSPESYVAEVIDNLKAKLRDFQGEFSKPQVREKLESMLDDRVMNILEQLYWNDVKLNDLGKNNIESDHDNYWAYKLDTARSLLTKSGIGRDSTSLVADGIRNLIEALTDGPPFSHHNNAAERIIELSHDILRDKLSITSDQVENALKPFKFEVDVEDKEWNKGRRHVLSALEGEQKECDAKLSEIRKRVGGYRKLNNIISYLKSLDERKLNQEAEIENDGVNNNEPAWKLAYNPAHLIEARQAMKLSERLAILKLRMSTLRSSKCKFGNGDNTKVETICPEAFLTVVSEKLAYTSSLFLQIELLQSFFDQFPREIDSRLMYDLDRNAINKFARENPTIRSHLDLQERKDKLEDVLKRLESLLHLKEQDKPKARRFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEB9</accession>
    <name>I4YEB9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_68297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957567.1">
        <property type="nucleotide sequence ID" value="XM_006957505.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YEB9">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEB9"/>
    <dbReference type="GeneID" id="18475375"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68297"/>
    <dbReference type="eggNOG" id="KOG1808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000050_0_2_1"/>
    <dbReference type="InParanoid" id="I4YEB9"/>
    <dbReference type="OMA" id="ILEQWHR"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001053">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="4720"/>
            <end position="4918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="4044"/>
            <end position="4621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3453"/>
            <end position="3480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4044"/>
            <end position="4062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4086"/>
            <end position="4108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4109"/>
            <end position="4151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4170"/>
            <end position="4185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4193"/>
            <end position="4206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4207"/>
            <end position="4243"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4256"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4278"/>
            <end position="4313"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4314"/>
            <end position="4325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4326"/>
            <end position="4342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4343"/>
            <end position="4353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4354"/>
            <end position="4364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="4368"/>
            <end position="4390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="4406"/>
            <end position="4454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4609"/>
            <end position="4621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="4930" mass="551817" checksum="B6B948ED0DF15AC6" modified="2012-09-05" version="1">[encoded data, 4930 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEL3</accession>
    <name>I4YEL3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006957590.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="wse:WALSEDRAFT_60055"/>
    <dbReference type="HOGENOM" id="CLU_581668_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEL3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="470" mass="53036" checksum="AFAAD8D8FDBFF504" modified="2012-09-05" version="1">METLSSHLHPSSQRVTFTRNTRSEVIYYVNELRATRLIEDETFFSSAFANKTLLVTPLNKYEVHQIWLDSSKRLSGFPLITFADTLIKLGRVHALETRYYCARYQMMKSMAKTQADDKMSKSLISWNRSLMKDIIDQGTSDGLQFKHIEVDCRHTFKKDHWPSNEIMSEWVKAIIPEEHHHKIINVFDDLNGVSGEGGSMPQYLASRPWHTLHLFAGDDRLSRDVDSLEASYAILQNNGSTAVSLSTSPYHLCEMPAAYKELMDNNSGVERLLSDLSVLSIHEKPLLFPRRITPASKVTEIALDWSSKFMTVIKSICDQRTRKAAGGEIGSLEMDTEGEAIVIFDDDMIVDLDDNSDDDITVINSDINDEKISQSIQIKKVVGKSAFECLSRTTGIVEDDCDCSSCRDILTARSENITHGELCICNTGKCAKTCKRIKNVKAVVRQYTEAIIVMNTLSNRALKSSTEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YET8</accession>
    <name>I4YET8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_37328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957720.1">
        <property type="nucleotide sequence ID" value="XM_006957658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YET8"/>
    <dbReference type="FunCoup" id="I4YET8">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YET8"/>
    <dbReference type="GeneID" id="18472008"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37328"/>
    <dbReference type="eggNOG" id="KOG3419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_2_1_1"/>
    <dbReference type="InParanoid" id="I4YET8"/>
    <dbReference type="OMA" id="PNDYNER"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="123" mass="13835" checksum="AFF3B8E82A0FB7EB" modified="2012-09-05" version="1">MSGVRLRLARHGIANRPFYHIVAIPAQKARNGQPLEKLGEYDPTPRIRIAGTPARKLIEWNKQRIDYWLSVGALPTQPVTKLLMRGGIIPENNKYLKKASPQPKLPRSYSEPSPIPNSSTTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEU3</accession>
    <name>I4YEU3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957725.1">
        <property type="nucleotide sequence ID" value="XM_006957663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEU3"/>
    <dbReference type="GeneID" id="18471433"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32158"/>
    <dbReference type="HOGENOM" id="CLU_1302354_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEU3"/>
    <dbReference type="OMA" id="KSMHPES"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="22477" checksum="C0FFA0D077B465FF" modified="2012-09-05" version="1" fragment="single">MTRSKSDSKAVEDEGWTSASSANETPEKSPSESPRLTQSQSQPDLSSLPSQLKQLSVQPNEAEVEDLQTPKPSSSYAFNAPPRPLSITSTTSSKAPPSVFKMTSPLASVDTKTVAHAADSPQHSLSTTNLQDNLAAKLGYTSSLGAITRQNTSTPTTQTAPAKSHLVISNFTPAGSQDLPPTPTYSKLSSNPNLLGSHTALRTFFHPQKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX6</accession>
    <name>I4YEX6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_27800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957190.1">
        <property type="nucleotide sequence ID" value="XM_006957128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX6"/>
    <dbReference type="FunCoup" id="I4YEX6">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEX6"/>
    <dbReference type="GeneID" id="18471011"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27800"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650858_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEX6"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="192"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="344"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="422" mass="46254" checksum="A2E982FB5CCCD051" modified="2012-09-05" version="1">MSDVAELSSVDYFAYSVATWSTVTAVGLLGFPRLITTLLLPYEKHSTGELLPKTELNGFERFLTIQSSIALLAAAFLLLQLTGSLSSTPIRQPSPYRLPSVTFATTALVFSSVLAFYADSETIGLVGKVHCIPAAALSVWGISIMIFEIDAATYRRLRPREYLNRFLENDLRMDGRRLDEFRSTSINQENEGSIDTANGSAVVRLGNTTMIAGVKLKTALPDPNREAGYVVPNIDLNPISNSKYKPGPPSEEAQVLSSRINDVLLSSGVLNQKDLTIEQGKAVWVVYIDVVCINFDGNAFDAALIAIVAALRNTRLPVTRYDFDNDRVLANPEESTSVPLTKTIIPTSFGLFDGKLVTDLNDFEQSLAHSRLTVVINEDGTLAHMSSQGRNMADNLDDSLDLTQRAIKIARERYDAIAKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF11</accession>
    <name>I4YF11_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957223.1">
        <property type="nucleotide sequence ID" value="XM_006957161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF11"/>
    <dbReference type="GeneID" id="18475331"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68019"/>
    <dbReference type="HOGENOM" id="CLU_1556476_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF11"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19930" checksum="7E6409A7222285DE" modified="2012-09-05" version="1">MSEDQDLANRATGMYLGGNEPQVAAFYDHIRARIAEAVANERAAKEDAYRAFWQETTRKHEENRRERLLNDKDRDGKLKIREPPTFAGGIDTLKITGWVDQLNTYFKYVTDTEEKKTEYAAGLLIGHARYWYVQYRQTQGETPPPWEEFQLVLMETFSNQQKEAFASDSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF73</accession>
    <name>I4YF73_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31823</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957281.1">
        <property type="nucleotide sequence ID" value="XM_006957219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF73"/>
    <dbReference type="FunCoup" id="I4YF73">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="GeneID" id="18471373"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31823"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_2_2_1"/>
    <dbReference type="InParanoid" id="I4YF73"/>
    <dbReference type="OMA" id="WKRRVPT"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="447" mass="51363" checksum="A3A6CC09BA0EAF09" modified="2012-09-05" version="1">MAMADINRSGSEYESGDDDLTWPSAFTLIDVIDTYVDARIDLIERRIHETSDKLRERATSAKEKAAEIIRTRGSGTRIDDSTNDDDGEKKLQPAAARAKDFYEREAAKYKLLLSKRVQHLSTKWKDAKVVQLRDKLSFCFGVFNVLGSALLYALNPEWLHISYTIQILYFLPLRAYTYKRLSYHYFLFDMCYYATILNLAFLWLFSSSEAVFVAAYCMTMGPLALAVITWRNSLVFHSFDKTTSLFIHIYPPLVFHAIIFDYPNSTERFPALKNLHKLQTGKALLYTSVIYLLWQALYWKFILVERRHKIGEGEGKRTTSFSYMLHHNHGLIGRTLSGIAPKWRESAFMFMQFAYTMVTMLPAVFILYDSKVASGTFLLFIFGVSTWNGASYYVEVFGRRFEKELDALRKELEIASSTNGDAEDDTSPKSENDEVDNGNNVSSKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE1</accession>
    <name>I4YFE1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957347.1">
        <property type="nucleotide sequence ID" value="XM_006957285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE1"/>
    <dbReference type="FunCoup" id="I4YFE1">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFE1"/>
    <dbReference type="GeneID" id="18473610"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59891"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFE1"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="25076" checksum="7F5795A01DD38197" modified="2012-09-05" version="1">MSSWMSWIVGKKDNRGSARDAIVGLRSQLLMLDKKEEHLNKKIEEELKKAKANATSNKRLATAALRQKKAFEGELDRIAGTRLTLESQVNALESANMNLETITAMKKGSDALKSIHGNLNIDKVDSTMDSIREQMDLTNEISDAISNPVHHDPVDEDELNDELEQLEQDELNNRLLGAERAPVHAPVAAGPQATASIPATASQSTPAAQSQEDDEDEELRQLQAQLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFQ6</accession>
    <name>I4YFQ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957452.1">
        <property type="nucleotide sequence ID" value="XM_006957390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFQ6"/>
    <dbReference type="FunCoup" id="I4YFQ6">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFQ6"/>
    <dbReference type="GeneID" id="18471398"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31946"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="InParanoid" id="I4YFQ6"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="417" mass="45382" checksum="47D13AE66A4EAC98" modified="2012-09-05" version="1">MAVKDVFWTKELPTTAASKMLRNFHPEEDAECVQLARAAGASFIGKTNCDEFGMGSSNRYSDFGPVLHPFSPERLAGGSSGGSAAAVALQECDFALSTDTGGSTRLPASYCGVVGLKPSYGMISRYGMIPYAESLDCVGIMARKVGIVKRVFEVLSQYDEKDPSSESSEVRKRAIYGMISTKESSDTWKIGLPEELFNREPSEALSNVIDTLLKNGTSDGKRVELYQVSLPSASLALNAYYILASAEASSSLARYDGMQYGYRSKTGSVEETRAEGFGEEVKRRIELGNFVLSADAFDNYYLNAQRARTAIVEDFDRLFRLPNVRSKNDNYDLGVDVLIHPTAVSGPPKVNSSDTTDYSQDVLTTPVSLAGLPAMSIPIGKDSDGFPQGVSIVSQWGCEQTVFNMAHELENVNKKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB1</accession>
    <name>I4YGB1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1604-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957042.1">
        <property type="nucleotide sequence ID" value="XM_006956980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB1"/>
    <dbReference type="FunCoup" id="I4YGB1">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGB1"/>
    <dbReference type="GeneID" id="18475311"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67879"/>
    <dbReference type="eggNOG" id="KOG2138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008613_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGB1"/>
    <dbReference type="OMA" id="QLWQQHA"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="758" mass="84714" checksum="C376E50C42E5FD31" modified="2012-09-05" version="1">MSAARYLKRLERDKPGAGQAAAQASSNENFCLVGTPLPSLVDSKKDKNEYQPIWQQEVLDEQGRRRFHGAFTGGFSAGYFNTVGSKEGWTPSTWQSSRSGNTGKRARPEDFMDEEDLEALKEARVLETRPDYDLLAGSASDNKRQRVDDNDTFSNIFRPAKSGIGTLLMRKMGWRDGQGVGPRISIHKAKEQNPNLNVLEEHGEKHTFAPQDSSLMIPPRQIGSQGLGYAYTVHSLRSSDQGGTEKQTKGDISHGFGLGIEDADEDDIDIYGGPSLNIERGQKLNQLAYDDSKDYNGSATRQLEKQPPPRNLVGVEFFKDGKPLLKGFVLQKNNQISETWFDQPEVPKNWKPDPMRVLKVKINTQEDAEGTSKPIPRDANDRARILGEEVPKKSVFDYVSAQDKQRLEKEQSDFEDEQEIRIPPIDKATASNALRASIPFPEGDPKRARYTAYLHSQSDPQKYPPDVVNLPDDTQTKTQFNIELVEFQKTASLFKPMTAAMAGRFTTGSRTNVGTTETPSFEPGLRPGVTPKAKEPSPPPKPVEEVRAERDAERQRNETPLQKAVREGNLGIKTGTHTFTSWKPSKLLCRRFQVPPPAITLESDDSEAGFQFGKQTGGEAPQHKPSAWAAAGLEDVSLPEPPNVLELERHAAAKDRNPGLKQVGLGEDEKAMEMIAKQTRPPMDIFKAIFNESDDEDEEREKPGREKKAVTEKTSEKKKKKDAKKRNNLRSKLTFDDGESEEIQTSEKPKRRLAVDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGC5</accession>
    <name>I4YGC5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957056.1">
        <property type="nucleotide sequence ID" value="XM_006956994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGC5"/>
    <dbReference type="GeneID" id="18473522"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59728"/>
    <dbReference type="HOGENOM" id="CLU_2051470_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGC5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="120" mass="13915" checksum="192C13FA7C0A529D" modified="2012-09-05" version="1">MLYTSIIRITEEVTISHRMMFTCHMWRDEQEIAYNNLDKNEADLNQAANDFGYKWEYDHPDNDKACFAFGANLFERLNNGRIVGGNLAVHPQPGQLQVYEDECDQHLNNPSEDMGLLPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGP2</accession>
    <name>I4YGP2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956534.1">
        <property type="nucleotide sequence ID" value="XM_006956472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGP2"/>
    <dbReference type="STRING" id="671144.I4YGP2"/>
    <dbReference type="GeneID" id="18472797"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56322"/>
    <dbReference type="eggNOG" id="ENOG502S8WT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647599_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGP2"/>
    <dbReference type="OMA" id="RAINRRW"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47640" checksum="7F384A0CA9E2B635" modified="2012-09-05" version="1">MSEQTAQNDIRIKSQPLLSPSATISQQREQQQSYFPAILTNPKLGQLRGEFLSNTQRSKSEGYIGRRRRNIQERDSSLTARIGRDRDRDDDTPQQLDSYKSTFPSPLPPSLLPRNQPVPSTTVRGRSQRKSSSSAGDEGSFYISLKGIRKTLAPRGTGSARARFVVQTTESEIRSWILGSSSEVVINPDDNNHTLGRVIDATTTCNANGHQHDDDEECIELPSIIELSRSPSSLVWLIPEKFERFVVHCVARWWGVVSFSKTNNDGDRVTHLLKPRLPADKQVKHNHLDTPPVSEVDTASEIASETASDYQMSQSEAEDNAPANTSTAWAEITDDFERRLDVDKNTSDDDIRSNDRERMGRSRNMPERTSRAVRESDTEESDAERTSPNATRSTIPRKVVPKSASTHPWREPTVSFSEYLFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGQ5</accession>
    <name>I4YGQ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_15295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956504.1">
        <property type="nucleotide sequence ID" value="XM_006956442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGQ5"/>
    <dbReference type="FunCoup" id="I4YGQ5">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGQ5"/>
    <dbReference type="GeneID" id="18470659"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15295"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046313_2_3_1"/>
    <dbReference type="InParanoid" id="I4YGQ5"/>
    <dbReference type="OMA" id="GHSQLDW"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="46"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="141" mass="15843" checksum="7DF57FD9695355D3" modified="2012-09-05" version="1">MPPPSTTKSTPKPAHKVALQPGYGPLDWAKLKSSQEDLRQVEWQHPVPISPKMMSLHRGKANSVDDEIWCSFNGKVYNVTRYLPFHPGGEKEVLRVAGRDGTDLFMKTHAWVNLDYMLDECLIGFLVPNGRGVQDALIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGY2</accession>
    <name>I4YGY2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_43243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956616.1">
        <property type="nucleotide sequence ID" value="XM_006956554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGY2"/>
    <dbReference type="STRING" id="671144.I4YGY2"/>
    <dbReference type="GeneID" id="18472277"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43243"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGY2"/>
    <dbReference type="OMA" id="PSNGWIG"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="623"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="730" mass="83665" checksum="14AF80BB311CA31E" modified="2012-09-05" version="1" fragment="single">MVYTPYLSTAMSIDTQNGQFVDKDTGRVVILRGVNLAASKIPNNSPTQEIGNHYDDAENGSVSYSDRPFDMSTIDTHCQRLKSFGYNCIRYVITWESLESKGPGIYDESFIDHTIKTLRKLKSYGFYVFLDPHQDLWSRFVGGSGAPIWTIHACGLQPRNFSTTESALLHNEWKDGPQNFPDMIWSTNYYRLACYTIFTLFFAGKKYAPLCKIDGVNIQDYLQGHYIRAFKHLAEAIHAAGDLEDSCVLGWDSMNEPSCGLIGYENLGKLYDEQKVKLGSCPTPHQAFMLGSGYRTTVQYWEFTALGPKRRRDVVVDPGNTSAWLSPEEEPDGKSRWGWQRDPYWKLGKCIWALHDVWDDQTKKLKQPEYFKEVPQPFVDIHWKEFVTEWSSNIRSVHSNAILWIAPPVFERPCSFKDDTLGGRAALSHHYYDGLTLMTKQWHWFNADAVGLLRHMYKSVLFALKFGEKAIRNSLRNQLGALKDDAYLLSSKHYPTMIGEIGIPYDMKSTRKGKWKGGYGDQRKALDASLNACDGSNCLSYTLWSYVDFNSHEWGDGWNGEDLSIWSKDDMNSDTTKLKTLSYEESTLMPLIESNHGSSSISSNSSNTIDFLDGTRAPEAFIRPYFEYTNGTPLYMDYSISKKSFQGRIGYNSQVKETNVTEIFIPRYFFKNPKVDISEGDYEIDKDRIYWRYNFNNKSDKLITITDITESNIPQTSITNKIARLFSNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH02</accession>
    <name>I4YH02_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956635.1">
        <property type="nucleotide sequence ID" value="XM_006956573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH02"/>
    <dbReference type="GeneID" id="18473398"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59512"/>
    <dbReference type="HOGENOM" id="CLU_934488_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH02"/>
    <dbReference type="OMA" id="HNVWSEL"/>
    <dbReference type="OrthoDB" id="3353891at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="302" mass="34148" checksum="E99569C5FC1B7DAD" modified="2012-09-05" version="1">MRFLQNVNLKGIASLQTRSIHSTPIFLKAKQQSAQEETEEDFGDDLIGGTTEDAVESSNGLVEQVPSQSSPNSTWKTAVDYLSPKLADGKQIDPTNRPKASKVVDALVQAKNTEEIDIGIDLYRRWQSFKLGVNRNAHGQILNNLCKQGRSDIAFEFLSDFQKFNLTLPDRTVARTLSLSLHDKKDENATPLQLLPILRAFHYRPHDAFCVANAIRSVEQGDEMRVVLLDWIKDLDVHRVIPVEVSQLADAEKVWSDLRVIAEEEGKAGEWLDILGNKLLEKKSKSEKYAERKARKQQQRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH44</accession>
    <name>I4YH44_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_35743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956674.1">
        <property type="nucleotide sequence ID" value="XM_006956612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH44"/>
    <dbReference type="FunCoup" id="I4YH44">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH44"/>
    <dbReference type="GeneID" id="18471927"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35743"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="InParanoid" id="I4YH44"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="64"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="396" mass="43802" checksum="65E5EB10D219C628" modified="2012-09-05" version="1">MKLPNIRGIDAATLPANYPEPSHFDIEQIIRPNILSLEPYRCARDDYDQGILLDANENALGPTIDSDQSQELHRYPSPSHPQIKQSLVNLRKLPSIHYAFLGVGSDEVIDLLYRITCTPTKDMVITCPPTYGMYGVCAVINDVQVKKVPLDVNHGRFQLDLPAIKKAYADDTENKIKMTFVCSPGNPTGTLIKLSDIKELLEDPNNIGLVVVDEAYIDFTDEEASAVSLIEKYSNLVVMQTLSKSFGLAGIRLGVALAQPPLIQVLSNTKAPYNVSTPSARLAEEALSDNGIAKMKEFVAELKKNRDYLIEELSKLPNVGVVRGANDANFVLLPILDKDAKEDNNRAIEIYKYLAETEKVVVRYRGSELGCAGCLRISIGTKTECIELINKLKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW1</accession>
    <name>I4YHW1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_56143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956229.1">
        <property type="nucleotide sequence ID" value="XM_006956167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW1"/>
    <dbReference type="STRING" id="671144.I4YHW1"/>
    <dbReference type="GeneID" id="18472776"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56143"/>
    <dbReference type="eggNOG" id="ENOG502REC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1497360_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHW1"/>
    <dbReference type="OMA" id="TARECKY"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="180" mass="20534" checksum="5118F773BE0316B4" modified="2012-09-05" version="1">MQEKRAKEQDVIQPTLKRGQACLSCRKLKLRCSADKPTCRHCYKTRRECVYDSSEAQEIIRLLKAQQQTENAAATQRAVFYRHNPPGTSIQSFITQAPQTAPNAAMSTGQSRASPSYANYGQHHVQHYGQQYLPGAHVGDSYVIRHEEATLFDQNLQYLNQGCQSDYQDAYYFLNNAHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI32</accession>
    <name>I4YI32_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956294.1">
        <property type="nucleotide sequence ID" value="XM_006956232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI32"/>
    <dbReference type="GeneID" id="18473276"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59296"/>
    <dbReference type="eggNOG" id="ENOG502QQMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638102_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI32"/>
    <dbReference type="OMA" id="RINHEPR"/>
    <dbReference type="OrthoDB" id="10627642at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697821" evidence="2">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="45698" checksum="858D72EF6341C61C" modified="2012-09-05" version="1">MKFSIAVIALVATLLSTGAAAPLNTHEERGLLQSLAEPFTKGMQGQQGQGQGKGGAQGGQGKRGEGEQGGQAPFHGHGGPIGSPAGPHGGEDGHGHRITAEDVKGGHGHGHGEQGKGGFEKRQEGGHGGEAPFHGHGGPIGSPAGPHGGEDGHGHRITAEDVKGGHGHGHGEQGNGGFERRQGGEEEHKHEAIAGKKHEQEGGHGHGHGKDHCHMSPEEQQRIIQSGQYLECAWGEENYDHGAQGGQQGGQQGGSQGGQGQFQGGQGQFQGGQGQFKRQTEWEQEQQQHQQEQLQESIDQQRDAMHKQGAINHKTQDQQEQQGQQQKRGGEQGGEQGGNPEAEHQLQENIHKQKAVEHHQHDMEDEKHQKDIEWQHHAEEQVQQGAQQGGQQGGQQGQYQGGEAQQGQYQGDQGGQDQGQYQGGQQGGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI66</accession>
    <name>I4YI66_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_14640</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956135.1">
        <property type="nucleotide sequence ID" value="XM_006956073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI66"/>
    <dbReference type="FunCoup" id="I4YI66">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI66"/>
    <dbReference type="GeneID" id="18470637"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14640"/>
    <dbReference type="eggNOG" id="KOG0450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_1"/>
    <dbReference type="InParanoid" id="I4YI66"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="597"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="963" mass="108608" checksum="43B35A9E9299E7F7" modified="2012-09-05" version="1">MSYQKINSQLHTDHSSVDESWDAYFNSLDGKPPALPSGAAVGEIKEPPNQAFVNTPLDVPKTWRTSSSNNLTDHLKVQLLVRAFQVRGHILAKTDPLGIIEPERQKNIPSELELTHYGWSEPDLDTKTFDLGPGILKRFTGTGKTKMTLREIYDTCKQIYCGPIGSQYVHIPEKAQCDWIRDRIETPQPWNYTLEEKRMVLDRLVWSDSFERFIATKFPNEKRFGLEGCESLIPGMKALIDRSVEHGVKSAIIGMPHRGRLNVLANVIRKPGEAIFNEFSPVAPADDDSGGGDVKYHLGANYVRPTPSGKKVSLSLVANPSHLEAENPVVLGKTRALQFFDGDKDRLSAMGILLHGDAAFAAQGVVYETLGFHSLPGYGTGGTIHICVNNQIGFTTDPRLSRSTPYPTDIAKFIDAPIFHVNADDPEAVVFICQLAADWRAKWKKDVVIDLVGYRRHGHNETDQPSFTQPRMYQAIGKKQNILDLYVERLQNEGTFTKQDTDEHKKWVWQMLEKSFQNSREYKPSPKEWLSSSWDGFPTPSELSQLVLPVNATGVREDKLVEIAKALGNVPEGFTIHRNLNRVLKNREKMVQDGKGIDWSTAESLAMGALAMEGNHVRLSGQDVERGTFSQRHSIIHDQKTGEAYMPLNHLGEKQAPVTIVNSTLSEFGVLGFELGYSLVSPDSLTIWEAQFGDFANNAQCMIDQFISSGERKWLQRTGLVLSLPHGYDGQGPEHSSGRIERFLQLCDDNPLVFPSEEQQIRQHQDCNMQVVYPTTPANYFHVLRRQVHRGFRKPLILFFAKSLLRHPMARSDLSELIGDTSFQRYLPDPHPEHLVAPEQVRRHILCSGQVYHTLIKHRDENDIKDVVISRLEQLAPFPYDMLKPHLDKYPNADLYWCQEEPANNGAWSYVSQRLITLVDNTECHKGKMPMYAGRPPSSSVATGSKAAHKAEIENFLHDVFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-03-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI73</accession>
    <name>I4YI73_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956332.1">
        <property type="nucleotide sequence ID" value="XM_006956270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI73"/>
    <dbReference type="GeneID" id="18474737"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62332"/>
    <dbReference type="HOGENOM" id="CLU_3108206_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI73"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698957" evidence="2">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="51" mass="5391" checksum="1F801F2B12C1CB26" modified="2012-09-05" version="1">MQFKYLISVAVLLTLTVALPAEGKDGEFQFAGTSGTRANNGDFKGKSGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI85</accession>
    <name>I4YI85_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_59338</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956343.1">
        <property type="nucleotide sequence ID" value="XM_006956281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI85"/>
    <dbReference type="STRING" id="671144.I4YI85"/>
    <dbReference type="GeneID" id="18473294"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59338"/>
    <dbReference type="eggNOG" id="KOG0341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_5_1"/>
    <dbReference type="InParanoid" id="I4YI85"/>
    <dbReference type="OMA" id="FKTIWTL"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="192"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="387"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="590" mass="65640" checksum="24645F14552EE198" modified="2012-09-05" version="1">MPGIDDNNDIGFDISDDDIYVPIAQRRATLLGNKKTSENDDRPNSSLDFLNDDSNKASTSSKTLLEESQVILSEKKTQDNMKSDIQRRAEEDADIVDAHTKQQRKLIPAAELAHGISYSRIMETSWKPPEYIRQRSSEGNSLIRRKHHILVEGSDIPPPCETFADMKLPGAILRYLKFKKILSPTPIQIQGISTAFSGRDMIGIAFTGSGKTLSFSLPTLMFALEEESKLGFDKGEGPIGIILCPSRELARQTHDGLIQMSRALNDDGYPLVRSLLCIGGISMQDQSETLQNGFHIVVATPGRLLDMLEKGKITLFSCRYLCLDEADRMIDMGFEEDVRSIMSFFKHQRQTLLFSATMPKKIQDFARQSLVEPILVNVGRAGAANLDVLQEVEFIEPEAKMVYLLECLQKTPPPVIIFSDLKNDVDDIHEYLLLKGIEAVAIHGSKSQEEREFAIETFKSGRKDVMVASGVASKGLDFNDIQHVINFTMPKEIEDYVHQIGRTGRSGKTGVATTFVNHSVPEQTLLDLKYLLKEAKQRIPSFLHDVVDPFDGKPSGCPICGGLGHSAVNCPKLEDAQKRKPKGDEIGSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIC3</accession>
    <name>I4YIC3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956380.1">
        <property type="nucleotide sequence ID" value="XM_006956318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIC3"/>
    <dbReference type="STRING" id="671144.I4YIC3"/>
    <dbReference type="GeneID" id="18473306"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59355"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="InParanoid" id="I4YIC3"/>
    <dbReference type="OMA" id="KGYWVQG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="322" mass="35244" checksum="98CC33E0FBB7F7C8" modified="2012-09-05" version="1">MSIIEPNLERDYTKVSSKVSEKNVIVTGAANGLGKELVLELLDHGATILAADIDEKGLSKLTKHPRLFTKQVDVTNYHNQLSLFRYAREVLGRIDIVYANAAVGNSPDYTSDINDEIEPDLRVVDINVKGVLYTTHLAVKAFREDKRDNIAQDQCIVLTGSFTSFLSTPAYPAPYAASKHAVWSMMRSLATQGEVEGFRANIICPWFAPTAMVIPSVRLLLTGVGMAKVEPIIRAFVIAGSDPSLSGNGFVIDTNGLFIIPATLIDAQCAIAFRQRFINVLKIQNTLRTYHTPIRFIGSLLGAIGVLMGVSFATSYLNIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM0</accession>
    <name>I4YIM0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956475.1">
        <property type="nucleotide sequence ID" value="XM_006956413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM0"/>
    <dbReference type="GeneID" id="18474754"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62481"/>
    <dbReference type="HOGENOM" id="CLU_1604027_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIM0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="166" mass="19185" checksum="75FEFE3E1C0B01E1" modified="2012-09-05" version="1">MNGNTSSISLSSESSTWRERFKKFKQHRDAKTVPVLHFQTSTPPPASLQLPAQKTPSPTRVDEASIIDSYQKPEQEDLYLSNHHRSFSPSSLSVREPISSKECLQRAKFLKERAHDYLQESRILLDRASVMAFEEASRSHDKALRREDWARRAKKHADRLENIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM5</accession>
    <name>I4YIM5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_56308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956480.1">
        <property type="nucleotide sequence ID" value="XM_006956418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM5"/>
    <dbReference type="STRING" id="671144.I4YIM5"/>
    <dbReference type="GeneID" id="18472794"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56308"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393398_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIM5"/>
    <dbReference type="OMA" id="EWLTHQA"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="686" mass="78495" checksum="F5777A189AD32E91" modified="2012-09-05" version="1">MPKKSSDRLVNACYNCRNAKSKCTTSNTESSCDRCNKRGLECVVDSIIRRRGKDRKPRVSNKRKEASKESSEITDVAVRSSTRQLSNRTSSSTKTSSITTRNSTKLTDNSHKDSIKDRLFSSNNNNDILHTTNFPEFAYQTSFNQSANSATVPLLFNPTSDYQQSTYWDVLIMEKMSEYHIDRNTAIKHIVGDLWIVFSRADLIATMFHLPTILEVIRSQQKRDTLEPALIYILLAISYAMQGRSDKPCATQSKLKALNYAETSYTHLMSAMSTNKMTLGVAQAAICLQYYELFPKPIFDVQKTGACLVIADAVIRTLALTCLDADKVEHVYDDDGISITTTDLETTQQRPLTPISNHSSPLPELCTQPECNCQKWTYDELHMQKKEGIRFRFLPRFAINEISDEKEIKDEEIRRVVWTALNQSWYQQMFQPTLSPLYINDSSNYGIFLTSERYVSNLPNPTDRDWSRRTLYALLDRGKLLCHGAMRLRLPLLEFHIKALKIVREADIIETELEKHTCHNGIPRWQVSNVVFLTKLVLTAKLRRITDFKDGQRSYFTRIQAKKWLGDHGNIYRQFIGGGIKDAPMILGVLTVQALRCLDLYGIDGDLVMALYVSRGILAAIEQLLHFHPCDSPDVQRMLDKVRNSCNFEHESMKKAFKPPNPPPHPPTFEELQQYIVEHNTISEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP1</accession>
    <name>I4YIP1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin filament-coating protein tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955680.1">
        <property type="nucleotide sequence ID" value="XM_006955618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP1"/>
    <dbReference type="STRING" id="671144.I4YIP1"/>
    <dbReference type="GeneID" id="18473094"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58962"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIP1"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18896" checksum="8D0FBFA4541472E3" modified="2012-09-05" version="1">MEKVKEKLNNLRAEADTNLERAEVAEERIKKLEQESLVREQEVQTLQHKLGLAETDNENLEGRLTDLKGFRDEDDAHRTNAEGLQRKIALLEDELDNAEKNLKDVTEKLRQVDVKAEHFERQVQRVEQERDGWEKKYEDSQEKLAAMKRELDEVIAQMNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIU2</accession>
    <name>I4YIU2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955728.1">
        <property type="nucleotide sequence ID" value="XM_006955666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIU2"/>
    <dbReference type="STRING" id="671144.I4YIU2"/>
    <dbReference type="GeneID" id="18475148"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66777"/>
    <dbReference type="eggNOG" id="ENOG502S6Y9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430953_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIU2"/>
    <dbReference type="OrthoDB" id="3269050at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="75245" checksum="A5975DE22E529300" modified="2012-09-05" version="1">MRPDRYNKRELIELHDTSTCVTINARVIDKRSFGIERFILPELVVEVDGFDSPLQLRIYDKAMITNRQRFNRWNNKLELAYINYIKQENVNSLLKNDKLMRDIEIAVNKMHNLPIDVDFPSCEYSHLEREAYFHYKVKKSFEHTREYYEKLSKNIGQRLPHIHGYYTIQIYDDQQDDLLKVDAILMEDINSVYKRSNESVFDKAPVSQWPDISNQMFDIVKKFDEINHVDLHISLQSFKYRVNDDGKYHILIDDAKFGRFRNENDNDEQWRRLKRQANELNQLGLQILCQFEENGQNYDFKPSFKYHKDHQGDSINMMKYASYLNELGPTFNRYRRDIGYSIDFPYAVGDKIPLSVEKSSLTSSNQIDVEIVKIFQPVTVSPAMLVRFDNQIMVLKLYDRRCSPMGRFVTKDDNGYEDWNEDIEQDYRNYIENESKIDFNIDAYMQNESERDHARDEEVLRRNCDDFFTTELKTYNALEELQGNDIPKMYASVKYTTYNTPKKHLQGYFDIPGLLLEYIPGPKLDKMFESVDQSHWFGLVQQTTTLLHRMFDLGVTNIDARPDQVIVRAHNDGYHPVMIDFGECLLREDLHNDSDNNRWNIENNINGIMQQKFDEIGVEFRYEHKGFVGGCCSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIW5</accession>
    <name>I4YIW5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_34405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955748.1">
        <property type="nucleotide sequence ID" value="XM_006955686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIW5"/>
    <dbReference type="FunCoup" id="I4YIW5">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIW5"/>
    <dbReference type="GeneID" id="18471860"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34405"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="InParanoid" id="I4YIW5"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="461"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="691" mass="78322" checksum="FE48D399AAA2552F" modified="2012-09-05" version="1">MTSVNEQVLRKLVEKDKVILPKDNEDNILISSALPYCNNVPHLGNVIGSTLSADVFARYNRIRNRNTLYICGTDEYGTATETKAIEDGITPKELCDKYTAIHKEVYDWFEIEFDKFGRTSTDKQTEIVQDFYKNIRKNNLLVKSTKEQIYSVEEDKFLADRFVEGTCPYCQADDARGDQCDKCSRTFDSPLELLNPRSKMNPKSQLVTRPTAHMYLDLGKLQPALESWLKDTASQHNWPGNIVINSDREIVEARMKAGLQPSAITRDLKWGVPVPAIGDPEEDAEMAGKVMYVWMDAPIGYISITANYTDEWQKWWLNPKNVNYYQFMGKDNVYFHLCFFPSLLVADGRDWTRLKYISSTDYLQYEGGKFSKSKGVGVFGNSAKETGISPSVWRFFLLSRRPESGDTEFTWNEFIGANNNHLLKNFGNYVNRVLKFTAAKFDSTIPGEAEDVNLQYSDDTDFEERKNSFVKDINEVLTRYIDSMERANLRSGLDDVLALSRRGNEWIQENKLDNALLAENPRRAQRTVLVAANLIYIISAAIHPFMPSTSESIINQLDAPARTLPESFAIDLYPGHKIGTPSILFTRIDEKMEDVWRQKFGGSQDGQPKAPELSKKQLAKQAKAAKAAKETAKVPDTPEAKALNDSITAQGNRIRDIKSGAIKDADLGKEVAQLKQLKNDMDVMIKKLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIZ5</accession>
    <name>I4YIZ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955776.1">
        <property type="nucleotide sequence ID" value="XM_006955714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIZ5"/>
    <dbReference type="STRING" id="671144.I4YIZ5"/>
    <dbReference type="GeneID" id="18474680"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61766"/>
    <dbReference type="eggNOG" id="KOG1297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061714_4_0_1"/>
    <dbReference type="InParanoid" id="I4YIZ5"/>
    <dbReference type="OMA" id="NTRCALH"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="23388" checksum="4189C82EF400F37E" modified="2012-09-05" version="1">MSKNAYDRHKQWKYEQEKIYRRDFNLEAERDKGVTEFDLIKQNHKFLKDEDLYDSDEEVKETTEEVTDPYAQKLSDKYYDSLYKEFAIADLKHYKTQISLRWRTKQEVVDGVGETSCANIRCMTRESKLIPFELPFNYKENDIAKNAEVKVVLCRHCSKKLSYKQDKDKEENLIRSRREHNRSRSPESRKKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJH8</accession>
    <name>I4YJH8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955946.1">
        <property type="nucleotide sequence ID" value="XM_006955884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJH8"/>
    <dbReference type="FunCoup" id="I4YJH8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJH8"/>
    <dbReference type="GeneID" id="18473175"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59101"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_6_3_1"/>
    <dbReference type="InParanoid" id="I4YJH8"/>
    <dbReference type="OMA" id="FIPFPRR"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000004">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="708" mass="79514" checksum="99564D9DF62CFC54" modified="2012-09-05" version="1">MDNNKPLESPYLLHSYLDQCAARMTDFDRHTPHDNLEIAPNLVGSDNQVLGNIAGELEDEADDDEETAHSRQNLTRHLAETAVGVREMSKQLGRARVKSKIKSVMIITKARDHQVIRHTRKLALYLMNTPRGDLKGQGMVVYVDSQLRTSKRFNVAGMREEYPHLFTPRPRSRSTSQQDLKDMSFSLASTSISPENNKFLHPDHNAHSKEEGQLRFWTPEMCTESPHLFDLVITLGGDGTVLFASWLFQTTVPPVLPFSLGSLGFLTNFDFTNCEKVVNGILDEGIRVNLRMRFTCTVYRSEYRKQDPNTEKARRPAVRRGETGEIIMRNIEGKGWDALEGNTPPTTTKEGKKRDKEIMCFTTRPVETFNVLNDLVVDRGPSPYVSMLELFGDENHLTTVQADGLCVSTPTGSTAYSLSAGGSLVHPEIPALLISPICAHTLSFRPMLLPDSMELRICVPFNSRSTAWASFDGRGRVELKQGDHIKVTASKYPCPTICADKQSSDWFQSLNRTLHWNERARQKSFVVVEEGPDHAELKNTGEGENEEKEEYYDDDDDDDDDDDQYDIDENSEYGDQSMGSLSGPGRARPILSKSFTSAFEPSVLNGRGSPGRYATTTTQPKPQPVSLRHMYNPSEELRHRQSRSVSKERNSRSRQPSLDNVNENSTMGTPRSRMKQLSEDTQPPMSPTTSARAFGVYGEDASESEMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK0</accession>
    <name>I4YJK0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955967.1">
        <property type="nucleotide sequence ID" value="XM_006955905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK0"/>
    <dbReference type="STRING" id="671144.I4YJK0"/>
    <dbReference type="GeneID" id="18473181"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59115"/>
    <dbReference type="eggNOG" id="ENOG502QPZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032159_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJK0"/>
    <dbReference type="OMA" id="RNHRIMF"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="597" mass="67598" checksum="74CD39B83F02141B" modified="2012-09-05" version="1">MAMSNGEISKTAKSSLREMQDPLLAFPPELVLRILAELDVQSLSNMRTSNKSWNTFIDVHEDVLFNVVRDKFGRMYDDIWKTTETIGAGYNGCSNWRDYFRNDNRINENLKSDAPKVFERFVNTGNTLTWRFKPDFEKQFVVVTAHQGGVKVFDINTSELLWEIPEADVRPHAHLEYSNGYFCIDRFGNALEVWRRNDIENQYRSEDNKVEEKRGHFTRVTILPHERETRGFQLCYPHLSVVSSEGHGYLYDVAGAPSLVRQIDIESGAIGHLDQCPTAIAFSIGTHGYHFHSKEDGRLLGVFPPEESNLTPANFFHVHHPQPPMPGSSARTEEISNQHIASTRIGRGKLKDHPSERTMPQDLPALRSDDWGAGMIDGPYFVGISRSGRLVLCSDWEATLAEPNLASQTVSVLESETDDSRFDLGGWLSVRHGKVLFEVSDRIYILHLPAQGELINPENSPPIQTLPSNSYAQLPVPISYMSVHSDAIMSTYATLLFNAVRIGVAKHIRISSFAGQVDDESKWIDPQSPENEDPHRNFILEVMTEHHEHMVMPDAEDQIEDIIEEFDQEDGDWEDVDSEEEEGGENNSAEERTVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK07</accession>
    <name>I4YK07_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_30982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956111.1">
        <property type="nucleotide sequence ID" value="XM_006956049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK07"/>
    <dbReference type="GeneID" id="18471227"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30982"/>
    <dbReference type="eggNOG" id="ENOG502RXNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061843_1_0_1"/>
    <dbReference type="InParanoid" id="I4YK07"/>
    <dbReference type="OMA" id="DCQWDPN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="237" mass="27337" checksum="FAA1F957C15FBC52" modified="2012-09-05" version="1">MSANEQNKLDNDKNTQEDAPPLPDEDAPPLPDEQPPLPEEEEPPLPEGEEPPQSSAQAAQPQVLQGNNGWSAIFEPQSQRYYYYNQTTGVTTWDNPFSNIQKEEDKSSNKRQFYQEEDDAIDPDLAHLLPSSSKDPHGYVQAKFNTRTGQFNSKSWQTPEHVSAINKSRRQQAAFFDVDAFERQRNEDHFNKKAKIEQLGKDSVKQKLTKEQLKLYKEQKAAKRYKNKTDWLINDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y582</accession>
    <name>I4Y582_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668258">
        <property type="protein sequence ID" value="EIM19124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960820.1">
        <property type="nucleotide sequence ID" value="XM_006960758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y582"/>
    <dbReference type="GeneID" id="18475799"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70846"/>
    <dbReference type="HOGENOM" id="CLU_1050551_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y582"/>
    <dbReference type="OMA" id="HINALDT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="265" mass="29955" checksum="F2C13E62AA990CFB" modified="2012-09-05" version="1">MAGYSKKISPIDLPSSRDDLSISGDSISEDDAPSGSAGISRLSKFINWKRQSPRKETKSTDERVYNDKLEEEARVERDRSKFEARVILNIESAMYDTHQLIHTQNESLESRMKEVEHKNKFLAKHLLETDSRLAEQTEKIRVLEQTNKDLSTRNKQFEDRLTSPDDSQQELQELRTVVGKLQSDLKGLSVLALERIQGLEKTVEKGEVSHHKKNSSSLSSVRDENTPTVKSPTVKSPTKQQAVKRSPGSPVKQSPAIKARAKQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C3</accession>
    <name>I4Y5C3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_61605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960787.1">
        <property type="nucleotide sequence ID" value="XM_006960725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5C3"/>
    <dbReference type="FunCoup" id="I4Y5C3">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5C3"/>
    <dbReference type="GeneID" id="18474635"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61605"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5C3"/>
    <dbReference type="OMA" id="CIVECAY"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000017">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF72">
        <property type="entry name" value="MALATE DEHYDROGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="161"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="23"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="341" mass="35703" checksum="11F413F60FA3C921" modified="2012-09-05" version="1">MIPTVARAFSNTARSNRHVAVLGANGGIGQPLSLLCKLNNNVTKLSLLDLKGAPGVAADLSHIPTSAQVKGYNPENIGECLKGAEVVIIPAGVPRKPGMTRDDLFNTNASIVRDLVKAVAEHAPKASIQVVSNPVNSTVPIAAEVLKKAGVFDANKLFGVTTLDVTRASTFIAESSGKPTEGPNYTVPVYGGHSGKTILPLISQAQPKTELQKEVHEALVNRIQFGGDEVVKAKDGAGSATLSMAFAAAKFADEFIQGLNGKSVTVPSFVNLNHVAGGKEIQKEIGAELEYFSVPVTLGPNGVEKVSSIGQISDYEKQLFAEALGELQKNIEKGVAFANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5D2</accession>
    <name>I4Y5D2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960795.1">
        <property type="nucleotide sequence ID" value="XM_006960733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5D2"/>
    <dbReference type="GeneID" id="18475794"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70826"/>
    <dbReference type="HOGENOM" id="CLU_2442549_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5D2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="9702" checksum="E6A36C88D6518F7D" modified="2012-09-05" version="1">MGNCLSKKAQSRQLGGFSSENQKNTSNPSNTNGTPNRELAAKAAEERIKANESRGTVQGGGSMSMKLSQSRRNSKPIIPPIDKSEPLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5L5</accession>
    <name>I4Y5L5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIN1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960652.1">
        <property type="nucleotide sequence ID" value="XM_006960590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5L5"/>
    <dbReference type="FunCoup" id="I4Y5L5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5L5"/>
    <dbReference type="GeneID" id="18475778"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70708"/>
    <dbReference type="eggNOG" id="KOG3739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007847_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5L5"/>
    <dbReference type="OMA" id="PFQKFAH"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="4">
        <location>
            <begin position="410"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="TUG ubiquitin-like" evidence="3">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="5">
        <location>
            <begin position="770"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="892" mass="99175" checksum="B4E49DD9A471234A" modified="2012-09-05" version="1">MSLVSDTDYHLQLLRLAFIRHVSPSTPLKLAKSSTNPYLNVAGLTDVERWPEMEHIPASPTLNNAYTLTQASKSSDLIKPDDVPATRGSSLQYTQTIVGPGRSLALSMRTNARLSQDVAGRRRAPVEQRQRYLKPGKSDVDSSHDEPPPVIVHGEDNEESDTDNIQTIQSDEDEDDYVVDYDSQLVRNGTSPSSASYNVTSQVPNNNSLLTNVNSQTLSSADIPLQTRNTHTYLETRPRGTSTSTADADDEDDFRQQQIPRIASKIPDEQTSIGKFSKTTTNSPPISVAQPPHSPLALAVHNNTSRLLDSKRPLTMTRGNSLSAVEELNQETQQPQVQSNDSRQSPQSAVANRFRSASVSTTTTTAHAIDDRKVDPRILQKINKEKDKDNAKADLLKKRPLHPPQQSTVSALSKLIQTKTEAQKASQNGREVSYNPFRRLYAAMDASEIGSSVKLSLYFPHSNKPREPIRVQIRKDATCEEVIGFGLYLFVEQREKDSKEMLGNNTDDIKWTPEGWNLRIVEEDGEVDEDFPALDRLRPVSKFSFDELAICEATAAQVRSNQLAVSKVQRRQSRITEDPFTGTVNSNNSNGSTGNPLLAPSNPTNASSSSLEGAIEQSHQIITPTLSRSATAGVSSSLAPSVYLRIEVHPTADVSYTTTVSVPSDMYLQDVLEMVCTKKNLKNPNSWALLVKSAALVIPLDRTVASLEGVSSLMLVKRSHIDADLRLDRRMEMARSTNPNASIFKRLSKDPRSTIGSRQGTNSALDYTSAYRKYTVNRRILGLVGKHERVLAIDGDWIHLMPPEQKAALIDSSTKTRSYHAANIKTCKQIKKGEQHFRIDFWRGGNHVKRYEFEAESVREANEIITQVKNLMALFKSERNQLARIASKNEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5S9</accession>
    <name>I4Y5S9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960597.1">
        <property type="nucleotide sequence ID" value="XM_006960535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5S9"/>
    <dbReference type="GeneID" id="18474571"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61505"/>
    <dbReference type="HOGENOM" id="CLU_455084_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5S9"/>
    <dbReference type="OMA" id="VEHEMTI"/>
    <dbReference type="OrthoDB" id="3360482at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="576" mass="66211" checksum="0B4FA32F9B75B73A" modified="2012-09-05" version="1">MTEVLLPTKIPTFSSIFTRYAPRKSSLVKDYRPVQQKNTQFNLLKLPNELIELITDELTFNQNLVISSLNRRLRLLAYKKLFRHTKFHGPIDDSSLNLIGKYIRHLTVTFDPKELPQLHNLRAIEYLSNDPLTSSSLGQFALTSKLISLTLDITIVHPSRDFHLPTKLKHLKLSFRDDKDVHGNEPPDNMEDYTEDQIWFTIVLMSKLVQINSATLETLHLKLLLPIDTLSNASWPNLKELSVVRSFPNNNFILFLTRAPKLETLIIHGRPNNSHWITHSSDCFNGHKLLGSLKHLTLAAKPVEDDQLFSHLNTSLESFTIEDQLSTRSSHIILDNLRGIKLQVLRIEPLVTSLDWLMAVTDTLPTLRELHSKFSKLRKLRNESLEMYIEVLARFRQLDTLSLGWDLDEESDEPYTIIERDITMKKTEFYNNLAFISAKNKKPGLNNILSPSESSSSLTQTRKSSYDSQVTYMSSTSLSDLSSFDFTSPHSGSDVTVDTLRDEIRTQWNRRSNDRYWNFIETLSKRMTTLKSVNLKRYNASGDREEITFTLDNGRIKSGNWIPALGFPSKSQAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5U4</accession>
    <name>I4Y5U4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960612.1">
        <property type="nucleotide sequence ID" value="XM_006960550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5U4"/>
    <dbReference type="GeneID" id="18475117"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66443"/>
    <dbReference type="HOGENOM" id="CLU_2225262_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5U4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="12452" checksum="B7ABDB8C7221259C" modified="2012-09-05" version="1">MTPKVEDIDDKVNRLEKRIAELEKRDNFCILPNKHQENEESLLSIVKSLCKGFGILGLIAFTAIHLVFFFISSYKILDFNIEKYFIFLAESICKFYQLFGYCGWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5W3</accession>
    <name>I4Y5W3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960631.1">
        <property type="nucleotide sequence ID" value="XM_006960569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5W3"/>
    <dbReference type="STRING" id="671144.I4Y5W3"/>
    <dbReference type="GeneID" id="18474585"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61529"/>
    <dbReference type="eggNOG" id="KOG1931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004654_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5W3"/>
    <dbReference type="OMA" id="YLFACQC"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="6">
        <location>
            <begin position="556"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="852"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="115394" checksum="02422EC9E3DF3B50" modified="2012-09-05" version="1">MDFNNQRCIQINRLGVNGIEDPNCWDPLIDKLKELTYIGFNTNIQMRLQDVEKSENQINLPGWNFCTFFILKESIALSYIGINLYNEALQIYSQLEQLFHHRLVDNSVISQFADFGGLGDSDDSGDLLSTTKKPYRQMMLSNSISIFDFRLYLFACQAKILGDLLGNIEQVATQSLEFINSFGQTIVSHSKDLKMNFLQYWKFTSSMSVIQQCDKWFTEEQKVNDIARARVFSQVKAQLYELAISQLKELGVAFGIIPNKYPFIRHLPNTKRDKRIPQTSNDQLKWALEQPKEFDKLFVQLCSSGARYYREVGKYKEAWSLDLLVAGLNMERKNFESSLRFFQLLNESEARPSGSSTKVYALLGQVISHSNMNVEKDVKWATAAVDLLKTWSKLDENDSEYTKDLLDQTGNWKGFEWLLHELKSYTDTKGEPLSIPLEHIFKVSFMSARPKVHFKDDEDGSALDVSVDNFLPCGITANHVKFTFQSLKDERVIDYSSDNVVLNKGNNLLNTFCLSPANGTFVLAKVVVAFGIVFEEIIPESMRRQRCFLNIPFDVRALDVQLQRPNDVNIDTSGQVKLKIKSERASIDHAKIRLTSPDISFKFDNSKLVDNGSSNIDHDKSITVHNLHSCEWHTIDIPYESSDIYSSLVHIHVDYSTLGKARQFEKIVEYTIELPLSLEVKHTQTSDMIITSADIQANSRSNVRINDIKLQPDNRAEEFDEFVLAASEKSSFGFAISNENENDLSLMVKYSTIENEVYDLVHEMVHSAISSQNLSQHVEWITEYIVGHHSWDHCSGHEYRMVDDKVLEKKVNGLAFMDEERCTLKDAIITTIEKLPSQEVVTQRWSTCTLPIKLPRADVITTACISLTNNEKMLRIGEATSITMKLSTKGEIEGPLRYELETPLDEWLVSGKVRGEYNHIEGLEIKVSLLPIKMGLLNLPEVIIYKDDRRICTFIENKRKVEVIPKISPEQTFTVDLPRRELIDWARERERSGKLLQSSHVRVESTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y4</accession>
    <name>I4Y5Y4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960526.1">
        <property type="nucleotide sequence ID" value="XM_006960464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y4"/>
    <dbReference type="GeneID" id="18474551"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61472"/>
    <dbReference type="eggNOG" id="ENOG502RZIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y4"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="50388" checksum="33F6957B2C24C6A1" modified="2012-09-05" version="1">MNKLGGIAGILIFVSSLIAYAAETELAQVVQSRLGYSKPYFMLWLAHSSFSFCLPLHLLLLKLTSSVPSRLYLRGLALATRNELTPDAPQPSIGAGFWDILPLKTSLVRMFLLTGLATFAAICWWVSVKYTTVADLTAIWNSSAFWAYVFAVYILGEKLQKSKLGAVLLACSGVVLIAYGGERSSRDDPLEDGEVRPKFSAVLLGDLLVFIGSVTFALFEVCLKKYASISENDDEKDVLDDQSDAFSFGSIESDDDVESQKKANSRENFHDNEESDELYNKNIHEHEDEMNDTHNAQRPGSITHSNSASPLINNADSGNVHRMQFERTESSASISTLAIHPPFGLYPNLVSTTIGLITFFTLWLPIPILHWIGWEKFELPPSGVAYGYITAMIAFGMIFNGAFIALCFIWGPVMASVGSLLTIVLVQIVDVLVNHVPLTLFSVLGGSLIILGFVLLVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X6</accession>
    <name>I4Y6X6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_66073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960226.1">
        <property type="nucleotide sequence ID" value="XM_006960164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X6"/>
    <dbReference type="FunCoup" id="I4Y6X6">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="GeneID" id="18475083"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66073"/>
    <dbReference type="eggNOG" id="ENOG502RZKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_925018_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6X6"/>
    <dbReference type="OMA" id="ILWTAYP"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="300" mass="33079" checksum="214CAB2BDA298E82" modified="2012-09-05" version="1">MLSHSYAAFPPLQPPPGEHNPPIGIPKPVPVFEEPSHLGKTILWIAFAVFATTTVVNGLHATRLNKRRRTFHFLVGIILTVTTLSYLALATNFGAFYVPESHRHLVAPKHPPLRAIYIGRFVEWFITLPLTGFTLGLLTGLPWLDIAFGVLSIVGFILSGLLSGFQSNAVGVWFFFIISVLFYLAVVHVFGIRGFKVSRIQSDDVRVLYGPLTTLVLLTWATYAVVFALGTKSKIISFDFELVLYAIIDLAAKAAFSLWLILQHSQIIDEYAAALLPDSWVDPSGISYNPISTNEEGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y735</accession>
    <name>I4Y735_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIP41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_40777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960112.1">
        <property type="nucleotide sequence ID" value="XM_006960050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y735"/>
    <dbReference type="FunCoup" id="I4Y735">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y735"/>
    <dbReference type="GeneID" id="18472190"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40777"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039187_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y735"/>
    <dbReference type="OMA" id="DMILFED"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="267" mass="30677" checksum="B468A3054442A152" modified="2012-09-05" version="1">MSKNHKSEYKLNNWVINTQKSTIPSMKETEDLSEELGIPPPEMTFLDSFVELRDNDSDFKISFNTRDALRGVSKKNELRVSYADHWANSRQTEESSTIKPSQPWDWTYTTRYNGSTSNVFSTSNNVNDTIPIDKLSDTNQPILFYDDVQLYEDELGDNGQVGLNVKIRVMPFGWFILQRLFLRVDKVLFRMFDVRVYHEFNSGVVIRESTGLESSWDAVKQCLPPTDATILSDEPTIQATLKMISKYANEQCTKWDGLGSLLDVCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y738</accession>
    <name>I4Y738_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960114.1">
        <property type="nucleotide sequence ID" value="XM_006960052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y738"/>
    <dbReference type="STRING" id="671144.I4Y738"/>
    <dbReference type="GeneID" id="18473026"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58513"/>
    <dbReference type="HOGENOM" id="CLU_1483114_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y738"/>
    <dbReference type="OMA" id="IMIPLHA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="21355" checksum="F94EC3FC2E274E6B" modified="2012-09-05" version="1">MATDIQKLMGQEFLKYKVNNLENKVKDKSIYLVDITSLIFGLNVIKLWLKDGYTIYIPLYTIYSLDELKQSDNIKLEKLSRSASSFIEKELNKRKLHLQSIEYNNNDNHFDKIKKSLSQFNNQTQLVIATPTIETNYTFFDIKNIESSLNTTGYPINHLLPAEIEEANLYFKQKKLNKYKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C5</accession>
    <name>I4Y7C5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960009.1">
        <property type="nucleotide sequence ID" value="XM_006959947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C5"/>
    <dbReference type="GeneID" id="18471123"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29995"/>
    <dbReference type="HOGENOM" id="CLU_118232_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7C5"/>
    <dbReference type="OrthoDB" id="3406504at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="157" mass="17390" checksum="5CD4FD3670C64616" modified="2012-09-05" version="1">MPVIELYDREIVQNYIEKGEIRSSDLDVSNSAIHNLPRYIGLGSAIGGGSLFYLARRYQRRWTLPTFLGVVSGLVSGPIASAILLENHWKTEGRDPQTVIQTLSKISDESTSKLFERVAATGAKHSVSESQHNNGRDQSEDTTIMDNAKSNTINEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H7</accession>
    <name>I4Y7H7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of volume decrease after cellular swelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_40697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960060.1">
        <property type="nucleotide sequence ID" value="XM_006959998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7H7"/>
    <dbReference type="STRING" id="671144.I4Y7H7"/>
    <dbReference type="GeneID" id="18472187"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40697"/>
    <dbReference type="eggNOG" id="KOG3238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077804_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y7H7"/>
    <dbReference type="OMA" id="ENAEGWQ"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21475" checksum="9B244E3627A7743F" modified="2012-09-05" version="1">MKVIDKPVKAIKLQDFNDLISKTPGSFSELPTILRLRVDGCTVAGDCDLDGNERYSLYVTDKELCIYSDSLQKGISLDYPSIMLHAVSISTNSIFCQIDERTENVDDFESKDMHIHPPETSQLQEIYDQLSYCANLHQNKFPTDDNDNDDGEDAMFEDGVELSTTGAANLARLDDMLEEQDKHTDKKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7K2</accession>
    <name>I4Y7K2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_48430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960082.1">
        <property type="nucleotide sequence ID" value="XM_006960020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7K2"/>
    <dbReference type="FunCoup" id="I4Y7K2">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7K2"/>
    <dbReference type="GeneID" id="18472451"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48430"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y7K2"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="8">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="9">
        <location>
            <begin position="494"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="697" mass="75331" checksum="F0663FF8A9450615" modified="2012-09-05" version="1">MQDASAQMALLQFMTCGLETTAIPSSIHCDHLIQAYEGAESDLKRSIVSNKEVFDFLESASKKYGIEFWKPGAGIIHQLVLENYAAPGMLMLGTDSHTPNAGGMGMLAIGVGGADAVDGMSGTPWELKAPKVIGVKLTGQMNGWTTPKDLILHLAGKLTVKGGTGSIIEYFGPGLDNQSCTGLATMANMGAEVGATTSTFPYSNSMREYLHATARGPVAKAADEISKTGFLQADKDAEYDQVIEINLSELEPHINGPFTPDLATPLSKFKQMVQENNWPTKLSAGLIGSCTNSSYQDMSRVESIAQQAKAANREAVVPFMVTPGSELIRATIERDGVQSTLESVGATVLANACGPCIGQWDRREAKNEDNAILTSFNRNFKARNDGNLKTMNFLASPEIVTAMSIAGSMTFNPMTDILPASGNSKELKFEPPHGTFLPTEGFIPGDTTFAPEPTPEPIPETPVQISPSSTRLEILEPFKSHFENPEEAGELPKMQCLMRVRGKCTTDHISAAGPWLKYKGHLSNISENTLMTAVNDEDGKVNSAYDFQEKTTSTIPDIAKRYRERQQPWMIVVDENYGEGSAREHAAMQPRWLGCCVVLGRSLARIHETNIKKQGFVPLTFKNKEDYNKIDAGDQVETVGLKGLFAGDLNTPVSVKVTKKDGSVLDIPVNHTLSVDQLNWVRHGSALNAIAAAAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7K5</accession>
    <name>I4Y7K5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="13" type="ORF">WALSEDRAFT_33769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960085.1">
        <property type="nucleotide sequence ID" value="XM_006960023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7K5"/>
    <dbReference type="FunCoup" id="I4Y7K5">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7K5"/>
    <dbReference type="GeneID" id="18471741"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33769"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y7K5"/>
    <dbReference type="OMA" id="HSPASWV"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023446224" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023446225" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="101"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="459"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="490" mass="55164" checksum="62A182BAEB68A7E4" modified="2012-09-05" version="1">MPLGYRMPARLRRKAGQTLSWVEPLATSFPSRGGRSFRFSARRWTGYKNADQKDEQFRQKLPLGYRLKMAWKDTPTKWYPLPIGIGAVLIAFLSIKNRKFSDEPHVVFDGQSMKLQGPWQVHVIGALPLRQLSRLWGYVNSFEIPIWARPTGFKLYSWLFGCNLDEISPEDLTLYPSLGVFFYRKLKPGVRPIADSSLVSPADGTLLHFGSIENEQVEQVKGVTYSLDALLGLSNLSKPSDLIPFNNENEEHEHVAHTDFANVNGIEYSLDQLLGEQEKEGSTQDAAIEHDLSAAAISHDAKVAKELGEQAVQMNNFKKSYPAVKPGNKLFFSVIYLAPGDYHRFHSPTAWVAEKRRHFAGDLFSVSPWMAKRLQNLFVLNERVALLGRWRHGFFSMTPVGATNVGSIILNFDKDLRTNVGRRPPRTGAYKEASYENASRVLKGQPLQPGEEIGGFCLGSTIVLVFEAPKDYKFRGKPGDKLKMGESMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7L3</accession>
    <name>I4Y7L3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960093.1">
        <property type="nucleotide sequence ID" value="XM_006960031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7L3"/>
    <dbReference type="STRING" id="671144.I4Y7L3"/>
    <dbReference type="GeneID" id="18474432"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61272"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122060_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7L3"/>
    <dbReference type="OMA" id="CRTRHIT"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="192" mass="21893" checksum="B0FB8257119DE9DD" modified="2012-09-05" version="1">MHSGTKYVGGHSDLLCGILVTQASTDGWKVWHQLQQERLALGNVIGNLESWLGVRSLRTMDLRVKRQSQTASELVNWLAHDNNDSNVIRKVLEKVQHSSLQAEDKEWLEKQMPGGFPTIFIIWMKSEAIAKALPSKLRYFQHATSLGGVESLIEWRTLSDDRIDRRILRISCGIEHVEDLKSDLLQAFQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7N5</accession>
    <name>I4Y7N5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1777-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_21415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959908.1">
        <property type="nucleotide sequence ID" value="XM_006959846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7N5"/>
    <dbReference type="STRING" id="671144.I4Y7N5"/>
    <dbReference type="GeneID" id="18470888"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21415"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y7N5"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="12312" checksum="D7483CA943C7EED8" modified="2012-09-05" version="1">MLKYLQSKEAEEERKRAEEEERAKEEEKKKAHNKEEIASQEEEQEEDIDEDSLAMQQMMGFGGFDTTKGKKVVGNEEGAAKVHQPRTYRQYMNRVGGFNRALDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R8</accession>
    <name>I4Y7R8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_48206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959940.1">
        <property type="nucleotide sequence ID" value="XM_006959878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R8"/>
    <dbReference type="STRING" id="671144.I4Y7R8"/>
    <dbReference type="GeneID" id="18472445"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48206"/>
    <dbReference type="eggNOG" id="ENOG502S7YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126679_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7R8"/>
    <dbReference type="OMA" id="WGPAVQN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="15717" checksum="A3D0D5BAA71F5F2A" modified="2012-09-05" version="1">MLCPRVNRTSILIRNFSTSIKANASRQVVEPRGKFTDTTTLLSSFGRSLQEKCKIEDWNQLFSSSSRDFERIGMTPQDRKYLLWCLEKFRQGQYPESFAHEPSPKKEFRGWGPRVQHGKRVRGLLRSGEEPAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Z5</accession>
    <name>I4Y7Z5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_29839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959808.1">
        <property type="nucleotide sequence ID" value="XM_006959746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Z5"/>
    <dbReference type="STRING" id="671144.I4Y7Z5"/>
    <dbReference type="GeneID" id="18471117"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29839"/>
    <dbReference type="eggNOG" id="KOG4269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303078_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Z5"/>
    <dbReference type="OMA" id="MANIHIK"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="217"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="353"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="673"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="983" mass="109861" checksum="F84FB900653C25B1" modified="2012-09-05" version="1">MSSTAKILTLKDILDLKQEDPLLFLLQERNNLANQNNQLWSLIDKQKTTINRLNDELDGLPYQHSTPPQPSPPEIIAPKPLHLNNKQLLTQSPPPAQTPYMQSNHSFDDALTKFPIRPAMLSAIEKAQHSQQPPQRGPYMQQFNHSFNNLPQARTHFQQSQVVHQSPPIAHQSPPITHQSPPIAHQSASVIQKHPPQARTTEDKPAYFKLTPSLVPTLKLAVLSSSIKPNRDNKDSYAFTISVKYEQSNAEWKVEKSYDAIYALDMKIREIIKKPYFKHTKGRLMTLPDKNTFKDRSPNKIIHQKILLENYFNSIISIPHTYSIIPKNSATPHMELAAFLSSNFAKSSNGQINGHKDGYLTKKGKNFGGWKARYFVIGKEGILDYYEQRGGNHIGSVRIHDASIGRQHPQRFQSDPNGPESENAFRHAFLIIERHETTQKEKDRHILCAENDQERDAWINTLLWHQRAHSNAATSSPVFPHEVNTSPVNAGLIEEATPNLAAGGLKRRATSSSKPRSREGGSRDGDRPRTSDKPRSKDDIQPGNPVTLSSLPPDAASKFSIPKELQEARQGGSFELSHSNESQLSLPPREDSKGATTPLAANNKDIKISKPMNGATIPEGVKFGDDQQNEVVDDKEKSEKQQERERKAKSRGFWGAFSGSSKDKTQKAPVFGVSINDSLQQAQIAGLPAVVFRCIKYLQHVKADEEEGIYRLSGSSAQVKALKERFNNEGDINLVETDDFFDPHAITGLLKLYFRELPNSVLTRELHFKFLQVTELPDAKKRIRELGRLVSALPIANYALLRALISHLTDIVSNEELNRMSLRNVGIVFSPTLGIPAPLFGLFLTEFKYVFNVADDGKPAPIEESTDEEQEPRLSTTTTASDKPSSQETTPTEIIEDETVDVLMPAPKLHGEKKTPPPAISTKNLQANGQSAPLSPLQPIPPRPSRQRRDNRNSSLYEDVNVDSMLGLRPKNIREALASAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y844</accession>
    <name>I4Y844_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_48094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959857.1">
        <property type="nucleotide sequence ID" value="XM_006959795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y844"/>
    <dbReference type="FunCoup" id="I4Y844">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y844"/>
    <dbReference type="GeneID" id="18472439"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48094"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_2_1"/>
    <dbReference type="InParanoid" id="I4Y844"/>
    <dbReference type="OMA" id="NRMMVLA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="282"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="531" mass="58618" checksum="4D80693E9E9FC3CF" modified="2012-09-05" version="1">MLILFETSLGVTLFKLKDGKMTDPNLFKEFEDSESASSLLKLKAIHKFNSTTEALEDITSLQDGKLTKSLKKFLQDNIQSDKKTQSLAVMDPKLASTIAQKLDVNVVSDSTTIDLFRGLRSQLPNLLNGIQQSDIDTMSLGLSHSLSRFKLRFSPDKVDVMVIQAIALLDDLDKELNIYAMRVKEWYGWHFPEMAKIISDNIAYAKIIKLAGFRTNIPQTDLSGLLPEDLEQAIKVAANISMGTEISQTDIDHILDLSEQVISISNYRSELYDYLKNRMNAIAPNLTALVGELVGARLISHAGSLTTLAKYPASTVQILGAEKALFRALKTKHDTPKYGLIYHASLVGSAPQKLKGKMARMVATKTSLSSRLDALADAETKSDMSSATIGLEQRASLESRLRALERSIGIQRTRNEADVGAKKQSKFEYETNGNGTYNTNTDNLLPTQPTAPATEENGDGLTEKERRKAEKKAAKAARKSLGGAEEEATPSSKKRSRDDDEEEDASPKKETKEEKKARKEAKRAKKAAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8G9</accession>
    <name>I4Y8G9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_70017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959749.1">
        <property type="nucleotide sequence ID" value="XM_006959687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8G9"/>
    <dbReference type="STRING" id="671144.I4Y8G9"/>
    <dbReference type="GeneID" id="18475677"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70017"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778913_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8G9"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="9">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="356" mass="39575" checksum="9E2671C5ECF71964" modified="2012-09-05" version="1">MSTRPTAYNPKRVCLLSLPDLSEFPKLREWGIYFAGMLFASGWWFFFDAAIISKRTKSDDTFEDVPVRISFVDYIPAILSTFGMIIVSLINKSQISRENDDPYAWKARCWLFVGFALLAGGLAGSVSLLVIKYIVPEYPSHYVSYGIAVVIQNIAIMLSTILTWIVGQSDTEYESAGRLVQTDLQQVDETHFTFTLSKPEELNHVVIFLTGQIAFPEGIGATVHFLFPGYEKGWQLLGKLSNDKPSAIFRLRGSAIPSKLSSNTLNTVNNNNTQAIIGISVEPINQVDSQTMALTPTNTISAKSNESQEVAKRILENLFEFLSGFAHVGPETLIPLSTLQQWYNKVLTKLQNGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K6</accession>
    <name>I4Y8K6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959555.1">
        <property type="nucleotide sequence ID" value="XM_006959493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K6"/>
    <dbReference type="STRING" id="671144.I4Y8K6"/>
    <dbReference type="GeneID" id="18474277"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60993"/>
    <dbReference type="eggNOG" id="KOG0151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545339_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8K6"/>
    <dbReference type="OMA" id="MIFCTRH"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="254"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56853" checksum="CEF8E60BC1274566" modified="2012-09-05" version="1">MDSFLQELKREQAGRGPNKPDMGSQSEIDPHSTNIYVANLPINIDEQMFGEYFSRYGPIASVKIMWPRQEDQSRFKQPGYAGFVSYMSCKDAELAVKELDGSDWQGHALKLDWGKRVRLPSRAIFEGPVKRPAMPASYYDERDSKRTRTEETINEGHSTVTFDTETLNFLMSVVYNAKSHKYGPIAGFNELKMTGVQYTFLNDEHDPKTTFVHNRLQDLIPFDDDQPTNDSDAELTDEERSEHEKLQKQKQNDLGPIARKQFEIMLRQISPKRYSIAKLMVFAIDHSESYREIVDILIKSLLNVSTPVPRKIARLHLVSDILANSAVGVSGAWRYRDEIQKHLDKVFEHLGLVRSVFPSKLSQNFFKERVEVVLRVWSELFIFPENILDSYMLKLEDNGKKAVSELKSNSTLISQQDNESISSNPITPVSDETLKPTGFRPIGKEPEESIDGALLEDLDGAPMQDDIDGEPMQDDIDGEPMQDDIGAQPLEDEDIDGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y923</accession>
    <name>I4Y923_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_39873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959491.1">
        <property type="nucleotide sequence ID" value="XM_006959429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y923"/>
    <dbReference type="FunCoup" id="I4Y923">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y923"/>
    <dbReference type="GeneID" id="18472136"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39873"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y923"/>
    <dbReference type="OMA" id="DRSFSEW"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697508" evidence="5">
        <location>
            <begin position="17"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="801" mass="90331" checksum="AFC1A640FDC47D0C" modified="2012-09-05" version="1">MRFIYALFALAVGATAVNPIDSLLEELSSLTNYKPSSIPPSRYLHSQTGQIDNPNNYEILAQGITELLEDNVLLADLVFRAPPPFTHDTQLAFNLYKQLADEGDPTAHSILGFLYDTGYNNVVEPHPGLALLHYTFAALAGDTISEMTLGYKHSIGSGAEQSCEQAVEWYSRVADKAIDYYLSGPPGGHSLPLSKPKLSDLKGGPYGLGASVASTGENAFRPVIYAGKAKDSGENWHDLLDYFTYAANQGELQYTIRLGNIYYHGSVYTPKIGPADGSGAIAKDFKKAKYWFTRATRKIWPEGLQSDKQKEVSKYTKYLVSMAATSLGKMYLRGEGFESNNYISAFKWLERARDLDSAEAEYYLGIMYRDGYHVGVDLKKASAYFTSAASNGYPEAYVALGNAFLERNDIVNAIQNYEWAVNISRSFEGTYRLATLTRDSDCQSALAKFKSVAERGDWTHGDKVWKEANSRWEKANEWNRDSYGRNEAESALLTWWRMAERGYESAQNNVAYILDQDKQAIRLPRFDRPANDTLSKISLGYWEKSAEQNVLDSRIKAADYYFRGLGTDVNYEKAAALYLNSADTHSSALALWNVGWMYEHGKGLPMDYNLAKRYYDMALEVNNEAFIPVAISLIHLYAKSIWGMITGKEDSNVLFNNIQKAGTPREREEMEDRQSAQEAVNRVDWTTYEGETTSTQREFVDGLLERNALVEPQDGFESTTFIAVIMTIAAGIYLRRQAMARARQRTVDRLTEEITRRAHDQAGHTQPQESDNSENVQNNQNENNREQELRQRNTTNHDYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9E8</accession>
    <name>I4Y9E8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_55018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959380.1">
        <property type="nucleotide sequence ID" value="XM_006959318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9E8"/>
    <dbReference type="STRING" id="671144.I4Y9E8"/>
    <dbReference type="GeneID" id="18472710"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55018"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y9E8"/>
    <dbReference type="OMA" id="ITNESCQ"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="117"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="435" mass="48623" checksum="B1CE7D44D116644E" modified="2012-09-05" version="1">MTPDKRSRKSDRFIPSRTPLSKVSYNLDKAGLSDEKSSKPLSEDFFNTLGQETLAAPTPIETTTDANENEDNRQKRRRKSLSMHTTPPRTKVLQTTTQGMLQTRSLRRVSHTPKTVLDAPYMADDQYCNLMSWSCEDVLAVALQSHIYTWRSSHVSMLCDVQETSSALRVASLAWDPTGKILAVGLDDGTTQLWDVQQRQCIGQVCKQSAKVGVINWSSGVLACGSRDGSIFVKDTRMANTNLRLRLHKGEITSLTYSAATEALASGGNDNKLYLWDIRSRGRLLKSYTDHEGAVTALSFNPHHRGVLASGGGTYDRRIVFRDTIHQGRKTLGDYDTGSQVCNLYFSTNTQELLSTHGFSQYSRGNLVCLWQYPSMKQIASIRSHLGRPIYMGVSSDGTTVATGSGDETIRFWKLFPPRQENKPESVFNLTKYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H5</accession>
    <name>I4Y9H5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959404.1">
        <property type="nucleotide sequence ID" value="XM_006959342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H5"/>
    <dbReference type="FunCoup" id="I4Y9H5">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="GeneID" id="18472985"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58096"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y9H5"/>
    <dbReference type="OMA" id="WIQIWNN"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="585" mass="64814" checksum="B7BBD6837943AA82" modified="2012-09-05" version="1">MSPVEYNGTILEKDNNSDNKSENKSERTQKGSQEEPLTNFPTDHEFATLRKVSESVSLYALAIVVVELAERFSYYSSKVVAQNYIQYPLPYGSITGTPLAGDVDTSPGVMGRGQQVATGLTTFSTFWSYLTPVLGGIIADTQGRYITIIASSLIYFIGLLILTLTSIPSAITNNTTPLAGWITATILIGLGTGGIKANISVLLGEQIKSSVPYTQVLKTGEKVIVDPNVTIQRLMSWFYWSINVGSLSMLVSPAIEKNHSFWLAFTIPTVVFAAVPFILFALRNKLVHTPPRGTVLLEVSRLLRIVAKNIYSFNPIRWIRNLKDTQSSWNAAKPSVYEKEHGFVPKFITWDDAFVLEVKRGWSACKIFFCLIFYYISQNQLSNNLVSLSTTMQSGNTPPEVVKIIDPIMILATIPILDFLVYPFLRKKGIRFGPVLRIASGFILASLSMVYAAVIQHYVYTISPCGEYAATCNTKAPQNLWIVAPSYALMALSEVFGPVTAYELALKKAPVKLRAFVTSIFLVQTAFASAINEALVSVSEDPYLVWMYASLAIVTFLAGFAFYAMFHKRDRNEEAENAIGKDRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I6</accession>
    <name>I4Y9I6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_58099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959412.1">
        <property type="nucleotide sequence ID" value="XM_006959350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I6"/>
    <dbReference type="STRING" id="671144.I4Y9I6"/>
    <dbReference type="GeneID" id="18472986"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58099"/>
    <dbReference type="eggNOG" id="ENOG502QRPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022084_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9I6"/>
    <dbReference type="OMA" id="YNMAEEM"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="366"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="458" mass="51638" checksum="E77917CC951A9803" modified="2012-09-05" version="1">MLLCQFINEHNFNYTSVARSLSNHSLLVDKPAGYFTAENCESAYRDLSQGLDTDQWVNTLITNISDSLLRNSNKNASNPHARPQLILAKRYFKLHVEEIKKSIFEQEREFRAIVQDINQAEKRNKEVVDPSSSSSLNEPSTSATIDFKPATPQPAGDISVKEAEPIQQDVSSNKEITQNEEVEVAKESSPKDTEPMDTTVDEPENKEADDNEIEHEPENEESNKESVVIVKEPSSKEMEELQGSPVEPEEQPQKETSLEEAIPTEIPTEETKQEESSPAPLKESLSPNKESIIDTPRSSEDMQIDQKHEEVKETRRTSKRKSTAGDTASKTPDDSINLGNKRKKLTLDDGQKKTQKILLLCLQEITAHKAGTIFTQPIRKNEAPGYYDVVYSPTDLSTIKKKIRDGQIVTIQQFRANILLMFANSIMYNPPSSDIHQMAQEMMKASEKLISEFLSNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K2</accession>
    <name>I4Y9K2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959427.1">
        <property type="nucleotide sequence ID" value="XM_006959365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K2"/>
    <dbReference type="STRING" id="671144.I4Y9K2"/>
    <dbReference type="GeneID" id="18475640"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69772"/>
    <dbReference type="eggNOG" id="ENOG502SEY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2074979_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9K2"/>
    <dbReference type="OMA" id="WYTLNAV"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="118" mass="13447" checksum="0BA423D4420825EC" modified="2012-09-05" version="1">MVHFKGEYNSYRPNKYDMSNGLRRARVPFLYKNLLTGFVILTFTSTVYIYSIAAVNQDDFSDVKPMRRDKEIESISNNITSSSPPSNQPQHRGILNKLLELNGYKTSSSLIINNAPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9L5</accession>
    <name>I4Y9L5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959192.1">
        <property type="nucleotide sequence ID" value="XM_006959130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9L5"/>
    <dbReference type="GeneID" id="18475605"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69584"/>
    <dbReference type="HOGENOM" id="CLU_468680_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9L5"/>
    <dbReference type="OMA" id="GDMEEHK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="582" mass="65747" checksum="979EFB91490541AF" modified="2012-09-05" version="1">MDDRANVRALAVDKLRRAASLPRRGTSISKNTHNQPSVQQREQSLSESTQDQESTQLTHPTHPTHPTQPTQPIQDRPSSPASTTVYEPVEEYHDSDYDSEGNNLLKDTRETGQQVQVRHGNDTVTFSIMENTPRTQLERLSRQERALLTLSQLQHQLLSKHGNSLLNRSNSATARVNAFNKLVGTGQLNNLLNQRPPSRLLRSNTVTGAVGGRGSRDDARQAARANMLKRLGSRRELKNDPPTQIKRRSSLGDISKFDSILNTQPQILDTNLLLVPPTPGRARKSSLESNNSFGTPSSAENGDKFEYERMLNTSTRSIDINSSHSEVESDDDNESIIYEEVIEDNDALSSKEANRRRRQVHFTPSAYIDELRKTLGPDRLAQLLGPQFVDEFGINTNEEENKEEILNTNDLDLVVDNQIDEDIPLTEQIDIRESNYLATSNRKTRESMFKPQPQIHMATYSTENAGSQAQLARSMTTLAKTNNTEQTGKHKKIKSQRSFGSFRLLKNKPSIQSNKEFYDSDPKLSPFPALRFQDNGNQQGVDQEPIKELRKEASPRRSGSKLERKTSKMGQKLKRLFSVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U7</accession>
    <name>I4Y9U7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959269.1">
        <property type="nucleotide sequence ID" value="XM_006959207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U7"/>
    <dbReference type="GeneID" id="18474187"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60823"/>
    <dbReference type="HOGENOM" id="CLU_612816_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9U7"/>
    <dbReference type="OMA" id="MDEFAEC"/>
    <dbReference type="OrthoDB" id="10522863at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="46695" checksum="38D332CCEF1B492B" modified="2012-09-05" version="1" fragment="single">MMQQTEEEKERQQKLARAKDHLKKAQKKKKQHKSTESRDVSSLFTTTPTEESRSPLFSPPPEDVQKASEWDTLQASLENEVDNSSERDNKQPNAQNNREIELEHSLSAQQSEIDNLKKQNDDNLTNLNEKNNTIDALEKTIVELKNSSTDNQELTTLERKVDSIQAELMSNRQAHDDTRSTLTELEQERNQQRTENETIEHKLKESSEQLLRSKLDCKNSREELEKVRQENTTIKEQLETSTKTSEELRNTNEQLNAQLAELKDANTEKQRLEEELSKLTIENKTLISRLTTLDRDNASLKRTIEESQDNLSLDKEASAIPLNTNGQFVTAAARSLIPSSVMHKRRESLQMLKIRMNSQVSSPEMSSINEEPRMPRNQFMTNDDPLFFCAACETEEDQEGQGLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9X4</accession>
    <name>I4Y9X4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959292.1">
        <property type="nucleotide sequence ID" value="XM_006959230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9X4"/>
    <dbReference type="STRING" id="671144.I4Y9X4"/>
    <dbReference type="GeneID" id="18472978"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58034"/>
    <dbReference type="eggNOG" id="ENOG502RZVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1050548_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9X4"/>
    <dbReference type="OMA" id="HTTHPPN"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="259" mass="29647" checksum="89E1F6A9A0A5EFC0" modified="2012-09-05" version="1">MSQSEEDFKDFSQEEFGDEFGEFENEEDLSVDLLESEEERQVGFDKQILVTQYARDIHQDLSNTALPKALDYDYSYTRRQFLLVLGKPLNLDEIKVNKLPPLQLSLNQQDHTPTVANTSKPENTPIDPAVDIESIQLEIDNIDTFTLNLIPITELSKLRDNLRSNEQSVNQQLTYNLEQLDTLRNDNETYNTLISDLIKETNNKLSKNYSMRSKIQPKSVNLMERTGSAGLWGPNNLPKTPPERVLSPGLTLSGNRVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA01</accession>
    <name>I4YA01_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959058.1">
        <property type="nucleotide sequence ID" value="XM_006958996.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YA01">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA01"/>
    <dbReference type="GeneID" id="18471608"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33021"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA01"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="544"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="693"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="840"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="986"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1610"/>
            <end position="1637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1694" mass="191856" checksum="3E3BAA7D869DC132" modified="2012-09-05" version="1">MAERPIQFSEHLQLTALGINPASISFQTLTMSSDKFICVREGDGGATPKQVVIVDLNDLNNVMRRPISADSAIMHPDRKLIALKAGKQLQLFNLELKQKVKSHLATDDIVYWSWLNESTLGLVSDTSVYHWDIDAVGENSPVKVFDRHANLTGSQIINYRATDDGKWMALIGISSNPSPDGFRIKGAMQLYSRDRGVSQPIEGHAAAFSELKLDGNATPSKLFAFAVRTGAGAKLHIVEIDYQSGQTPYTKKAIDVFFPAEAATDFPVAMQISKKYGIIYLITKFGFVHLYDLESGTCIYMNRISGDTVFVTAEHESTSGLIGVNRKGQVLSVSIDENTVIPYILSTLNNVELAFKLASRGNLPGADDLYMAQYQNLMSNQQFNEAAKIAANSPRSILRTQQTIEQFKSLPAVPGQLSPILQYFGILLEKGELNKFESLELSRPVLQQGRKQLLEKWLKENKLECSEELGDIVRLHDMTLALSIYLRANVPNKVVACFAETGQFNKIIVYAQKVNYTPDYALLMQHIVRVNPDQAAEFASQIVNDPEGPKIDIERVVDVFLGQNLIQQATSFLLDALKENKPEQGHLQTRLLEINLINAPQVADAILGNAMFTHFDHPRVANLCEKAGLLQRALELYQDTNDLKRVVVHTPLLNPEWLVNYFGQLTVDQTFACLNEMLKVNIRQTLPMVVQIATKYSELLGSHKLIELFESFKTFEGLYYFLGSVVNLSEDSEVHFKYIQAATRTGQIREVERIVRESNHYNPEKVKNFLKEVKLPDQLPLIIVCDRFDFVHDLVLYLFQNGLTQFISTYVQQVNSARLPQVVGGLLDVDCDEQTIKNLLSSVHGLFDVNELVDEVEKRNRLKLILPWLESRINAGQQDAAIYNALAKIYIDSNNNPEQFLKENNIYEPLVVGKYCEKRDPYLAFIAFAKGFCDDELIYITNENGMYKHQARYLVKRRDLDLWAQVLTDSNEHRRLLIDQVSAVAIPESQNPDDVSVAVKAFMTAGLQQELVDILEKIILNPTTFSDNGSLQNLLLLTAIRSDQGRVMNYINKLDKYDFNEIAKIAIDNDLHEEAFTIYKKNDAHFDALVVLVEHIVSIDRAYDYTNKVNEPALWARLAKAQLDGLRITDAIESYIKANDPSNFTEVIEISERAEKHEDLVRYLQMARNTAREPKIDSTLVYCLCKTDRLQDAEDFLHMTNVADVLEVGEKCFNDGLYLAAKVLFTSISNYARLATTLIYLEDNQAAVECARKAGNTQVWKQVCLACVDKQDYKLARICGLNLIVHPEELQAIISLYESRGLFQEMLDLFEAGLGLERAHMGLFTETAIAYAKYQPERMFEHLKLYGSRLNIPKVIKSAKEGHLWRELVYLYIAYAEWDNAALNTIEHSADAWDHQQFRDVLSKVANAEIFYKALSFYQEQHPTLLTDLLTALIPRIDHSRVVSMFRHSDNLPLVRAYLIAVQNLDVAAVNEAVHDLLIEEEDWQTLLDVIDQYQNFDHLSLAKRLEQHELLAFRRIAAHLFKVNRKYEDSINLSKSDKLYIDAIITASTSEDVQVSEDLLSYWVDIGNKELFTAHLYLCFKLVRPDVVEELAWFNALEDFAKPYQFELRRQTQERIKALEKKVEEQANKTAKKEEDEDSQPIMGPGFNQTLMIGGPAGWNAGTNGVMPQQTGVMPQATGVMPQMTGLQGGFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA11</accession>
    <name>I4YA11_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959068.1">
        <property type="nucleotide sequence ID" value="XM_006959006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA11"/>
    <dbReference type="FunCoup" id="I4YA11">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA11"/>
    <dbReference type="GeneID" id="18474114"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60710"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046581_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA11"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="35084" checksum="D9C7E7E0B9EE053C" modified="2012-09-05" version="1">MNFISTAPLAGYNIGYSPFHRSRLAVACAANYGLVGNGRLLELSYNQQGDLFTHNTFDTQDGLFDLAWSEIHENQIVTAVGDGSIRLFDTQVKQYPIRVWHEHSREVFSLDWSTIDKLHFASASWDGTVKIWTPDNTNSLLTLKAHNGCVYNANFSPHQPATLATCGSDGQLLIWDLRTPQAPVKSIKASSTEILSLDWNKYTHNTLATGGVDKSIRSWDIRSSGCFSNLNGHDYAIRRVQHSPHTPNLIASASYDMTARVWDINKNAAAFIHDKHTEFVMGLAWSLFDPFVLTTCSWDNKTHLINLKDKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAD7</accession>
    <name>I4YAD7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_7644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958899.1">
        <property type="nucleotide sequence ID" value="XM_006958837.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAD7"/>
    <dbReference type="STRING" id="671144.I4YAD7"/>
    <dbReference type="GeneID" id="18475826"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7644"/>
    <dbReference type="HOGENOM" id="CLU_010089_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAD7"/>
    <dbReference type="OMA" id="SNKIMEP"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="45700" checksum="85F0694849BAD693" modified="2012-09-05" version="1" fragment="single">FDVDPRSAFLPPDEPLKRLDGEYSIWELALDAALQLPLQLDGSNNEVSEQWRDAIRSMLNVKPPTINSNGIRVVRRAYTVLSYIAHFYVHSSRSSEDKTTIPSSIAVPWNHTATALGLPPILTYASTVLWNWEYIDPSKGLVEGNLRAPLTFTRSRDEEHFFLTSAYIEAAGRLCLERMSQCLDEAFMADMSPDVSYRSMSKQLTDISNQINILTRILIDVRKECRPEVFYGKIRRWFNGPNGQSSWHYEGVDPPGVYRDYGGPSAGQSSLIHSLDAFLGVNHAPVDDDANYDDTFMRRMQFYMPEYHRNFLDHLLNVEPSCRDVVKASENDELKESYNKAIESMKVFRSEHIKIATLYIVTQSRKDTSPIDDSASEPKGTGGTSLVKFLKTCRDRTYSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ8</accession>
    <name>I4YAJ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">WALSEDRAFT_60671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958979.1">
        <property type="nucleotide sequence ID" value="XM_006958917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ8"/>
    <dbReference type="FunCoup" id="I4YAJ8">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAJ8"/>
    <dbReference type="GeneID" id="18474088"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60671"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAJ8"/>
    <dbReference type="OMA" id="MGKCERC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="335" mass="38059" checksum="E42F0EBDBB765037" modified="2012-09-05" version="1">MIKRPKTGQQVCKDCFFFAFEEEIHKTITDAGTFKRGERVAIGASGGKDSTVLAHVMKTLNDRHDYGLNLFLLSIDEGITGYRDDSLETVKRNKEQYQLPLKILSYNELYGWTMDRIVEAVGKKNNCTFCGVFRRQALDRGASSLNISHIVTGHNADDVAETVLMNILRGDVSRLGRCVEITTRGEDTIKRSKPFKYTYEKEIVMYAYFKKLDYFSTECIYSPEAYRGFARTYIKDLEALRPSTIIDIIHSAENIRISDVVQDALPKQQKCKRCGYISSNELCKACVLLQGLEKGTAKMAIGNKAKHISQEVTGDIRTIPMFKMPEQQQKAEQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAK9</accession>
    <name>I4YAK9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_29209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958989.1">
        <property type="nucleotide sequence ID" value="XM_006958927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAK9"/>
    <dbReference type="FunCoup" id="I4YAK9">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAK9"/>
    <dbReference type="GeneID" id="18471087"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29209"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAK9"/>
    <dbReference type="OMA" id="RVEDQHR"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="322"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="57294" checksum="4D3B9A1A8A1AD919" modified="2012-09-05" version="1">MGSASDCTHPVQLSGLCAICGKDVSQEQQSESYHISHSTANLTVSYDEAQRIGKTSKHTLLKSSKLALIVDLDQTIIHATVDPTVNELLQDPTLVYKGALNDVHKFKLGDFGLVNHHEFGSWYFVKFRPGLMEFLDNMNKLFEMHVYTMGTRSYALAICQLIDPSGKYFGERILSRDESGSFTQKSLQRLFPTDTSMCVIIDDRADVWGDSPNLVKVIPFEFFVGIGDINALNKRKKLRSNQNGDGDGDQEEQEQDSNESLSKQADQRPLAKRQKEHQQILSETIDEELPRLSKILTQIHSNFYNFKNAGDDPDTKEIIPTLKRKVLHGLKLVFSSVIPLGMPLEISGIYNLASKFGATIDHNYNEKVTHVVAAKKGTAKVEDAKKGDSAHVVWSEWLLDSCAKWEKMPEENYYLDGPPNNPKQVVQESPSKFDHVDWDTADQELEDFLNEEDSEGVENEDVTNEGTTRKRSRDSPESASSINSPKRHKADSDKSSDDFDDFANELDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT9</accession>
    <name>I4YAT9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958764.1">
        <property type="nucleotide sequence ID" value="XM_006958702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT9"/>
    <dbReference type="STRING" id="671144.I4YAT9"/>
    <dbReference type="GeneID" id="18474033"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60568"/>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391913_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAT9"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="77990" checksum="021CB79A2F176FB1" modified="2012-09-05" version="1">MEFPHHRQSQSLSSHRQSNSMLASPQSSPLSPNQTPFFYAPQAPTNQALFFHQQQQQWAAAAAAYHQQQMMFHQNHIFTPPNPDFTGRRRTSSGPQRPSSTHPYQESRQQTYSQVASLNPRSTASHRRSKSDALSKDDILIKNTTKATSRPMVNRTESSPAAATSSKKYEEEVDDFSPPMGRIRNNSHSSNDSRSSRQSSNHSPQSTRKDPPTLNNKSSQQSTRPSPLSQQSPLILNDTITNKNEKAGLKSRLKRALSNQNSMNQGPADDSAINKVSTIASPTVPKSQPGKQSPSPSPQLPTRTRAISESNKVRPGEANEASEKPAKKHSIFNSKFNVSTDNISISSAASSASVMLRKIGSVGKLARRSSFAGLTNLFNKDKERDSGGEEPEDINNKSIGSKLKKKKKNKRKKEPSISVSHATAEVDRHSTINEEPELIDGLSPAAALVKQHQEQVAAAEAKAKASTGHSQHNDFNHAGSDNKSKLPGAIDVKRDDDSILSQDDDDLNKGLQGVQIHEEEWNTSQYDSLDAPHRREHTLKGILKGAKTYRQEDFEERNEIRGRSNSYTFANALKDEEGREVQPHVSHQLPSPNPDKIDGISSRPSSMHKPIDKPVVNHTNSTSALPIQAMITLAAQPKRKCSFANSMGIQHTWPATIYDRRGEPATCNRLTPELAQMIKEEMNAFKMEEMRVHASSRLNTQFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ0</accession>
    <name>I4YAZ0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_46554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958807.1">
        <property type="nucleotide sequence ID" value="XM_006958745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ0"/>
    <dbReference type="FunCoup" id="I4YAZ0">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAZ0"/>
    <dbReference type="GeneID" id="18472388"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46554"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_1"/>
    <dbReference type="InParanoid" id="I4YAZ0"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="334" mass="35671" checksum="F1C3832AD24F5A55" modified="2012-09-05" version="1" fragment="single">MALVFGSINVDEFFSVPHIVRPGETLASTKITKKAGGKGANQAVALAKASAAVSLAGQIGEDGEWIRTLLQSFNVDTSLLKTNNSLPSGRATIQISSEGENSIVLFGGTNMLSYSDALPLSKYQFLLLQEEIVHSETTSTLIDAHSQGLKTIYNPSPMPNATQLRNFPWSSLSYLIINAGEAADLLKAFGEDPTSLSSAELLDKLMSNPSTGSLEGLIITLGENGLIARIKIEGIPTNYELPTIKVNAIDSTGAGDTFAGYFTACRMKMQTVDTSTMELALRNAMGVSECYYIVYSDKTQAAALAVTKSGAMEAIPEVNEVRDFLAHNDINCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ2</accession>
    <name>I4YAZ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60592</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958809.1">
        <property type="nucleotide sequence ID" value="XM_006958747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ2"/>
    <dbReference type="FunCoup" id="I4YAZ2">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAZ2"/>
    <dbReference type="GeneID" id="18474044"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60592"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAZ2"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="19999" checksum="4076A80E39178C5D" modified="2012-09-05" version="1">MTNYSLYSVHGLVILDSEGNRVMAKYYDKNQQTNLKEQRTFEKGLFDKTSKGNGDIILYNDKLILYKSMMDLIVYLIAPSEENELMLSSALNGFIDGISLLLRHQLEKTSVIENLDMVLLALDESIDDGIILETDSNAIASRVSRPKADTNEIQINEQTIMRAFDMVKDRVSKIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBF1</accession>
    <name>I4YBF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958646.1">
        <property type="nucleotide sequence ID" value="XM_006958584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBF1"/>
    <dbReference type="GeneID" id="18472936"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57623"/>
    <dbReference type="HOGENOM" id="CLU_481628_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBF1"/>
    <dbReference type="OrthoDB" id="3359595at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62376" checksum="E7C884BFAB8D8A5B" modified="2012-09-05" version="1">MIIWIVFIDNIGEKSLANTDKNSDVIIFVATAVVFLVVTLVIVFARGVKVGQALLGPVGFTSLGLLAMLLIPSSATDELWPRALLVGLLAGVGLGSFFFKPTRRAGQTLGVSWTGLFMFFLGVDILVESQDGFSLGLRKFFDSNLHHYIDLDKPYELTTPTIVMCALGITFGPILAVVQHKFHPSPKHQWGVDEEKRCNRRWISKDKRYRPSLPASNGTIIYGGSTATPSMTSSMSSMKKPMMSQRPAPPTRVRTRSSVMTFNKVPESPLESEFDGVQKLGYASGSSSDDSHVDSSNEKAGIEPVIVELKPDDKKEVEKEENSRDNKEESNDSGDEELSTYSNSTYSPTKRDLSVLTKSKSQAMSQARLAGSQAQLAQAHSQFADSQPQLDKSESNYTQSKSQNQSLALSQSNVFPESQIFASRIDSIEKIPMPPQRKIEDPILYDNYDTITKLEKHLSMIIEDRATENDLMSSMPGSPFTGPAPRRASVVSPTKVIDSPSMLTESATFSPVQSQMNINGVTLTEALTDDSREVRLKESMDAVSLHPSLIDDDDLNVIYKYNNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBT7</accession>
    <name>I4YBT7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_4247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958408.1">
        <property type="nucleotide sequence ID" value="XM_006958346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBT7"/>
    <dbReference type="FunCoup" id="I4YBT7">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBT7"/>
    <dbReference type="GeneID" id="18472253"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4247"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1810902_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBT7"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16426" checksum="51FA82744B11BD8A" modified="2012-09-05" version="1" fragment="single">KQSKVDEILLDNKLQRDKLNKYKSSLDRLIALNLDLAKNALKMNDVTQAKKFIQIKNQNIHKQEEIEKQLASLTGLISSIETQVAQQRLVEQLEKGNKLLTGLHKEMSISQVHNIVDNLSDQIEYQNEISNLIITHDPDLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC33</accession>
    <name>I4YC33_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_18863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958417.1">
        <property type="nucleotide sequence ID" value="XM_006958355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC33"/>
    <dbReference type="STRING" id="671144.I4YC33"/>
    <dbReference type="GeneID" id="18470780"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18863"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="InParanoid" id="I4YC33"/>
    <dbReference type="OMA" id="PLVCHIS"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="15129" checksum="6C50A4202FFA3D7E" modified="2012-09-05" version="1">MSYKEPAKITKHPVVGGKEPKSGGSTATKSTTSLRKGQKKRKETYHSYIFKVLKQVHPNCGISYKAMSVLCSFVSDLFERLAGEASILASKNGKSTISSREIQTAARLVLPGELAKHAISEGTKAVTKYAATSDLIAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC61</accession>
    <name>I4YC61_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_60312</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958253.1">
        <property type="nucleotide sequence ID" value="XM_006958191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC61"/>
    <dbReference type="STRING" id="671144.I4YC61"/>
    <dbReference type="GeneID" id="18473880"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60312"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="InParanoid" id="I4YC61"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="104"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="215"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM21553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="39700" checksum="BCF9DCFC2CD09003" modified="2012-09-05" version="1">MYAQEQLSPRILEASRNEDFDREILREMGQLGFLGASLKGYGCAGVSKVAYGLITREIERVDSGYRSAMSVQSSLTMYPIYTFGSESQREKYLPGLASGDLVGCFGLTEPQHGSDPNGMETVAEETPQGGYKINGSKTWITNSPISDVFLVWARCKWDGKIRGFILEKDMDGLSAPAIKNKLGLRASITGSIYMDDVHVSKEQVLPGVAGLKGPFSCLNQARYGISWGVMGSLEDVIARSREYALDRKQFKRPLASYQLVQKKIADAVTEVPLGLLASLQVGRMMDAGTWSPEMVSLVKRNNCGKALEHTRTLMEIFGGNGVADEYHVGRIANNLHVTNTYEGTHDIHALILGKATTGLQAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC91</accession>
    <name>I4YC91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958280.1">
        <property type="nucleotide sequence ID" value="XM_006958218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC91"/>
    <dbReference type="FunCoup" id="I4YC91">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC91"/>
    <dbReference type="GeneID" id="18473890"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60324"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_4_0_1"/>
    <dbReference type="InParanoid" id="I4YC91"/>
    <dbReference type="OMA" id="QHLFTKD"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="115" mass="13161" checksum="E8829FFF94FB6ECC" modified="2012-09-05" version="1">MKGQFVKELRPLMYSFGDDVNPDPEATNVLEEILIDFIMEICYKAQKASGNRGKIKIEDIKFVLRNDPKKLNRVEELLYMQEDIKRARAAFNEGDIIQDAVKSNRGTKRPASPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCE0</accession>
    <name>I4YCE0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative 5'-nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_28683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958327.1">
        <property type="nucleotide sequence ID" value="XM_006958265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCE0"/>
    <dbReference type="FunCoup" id="I4YCE0">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCE0"/>
    <dbReference type="GeneID" id="18471053"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28683"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCE0"/>
    <dbReference type="OMA" id="GQVNILH"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="483"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="581" mass="66646" checksum="8A485103BBCDDF00" modified="2012-09-05" version="1">MYSFDFRYKYLSIVQSLDGMWINNVLIFTSTILCYYYISKYNTPETPSRELEWGDINVIHTTDTHGWLAGHRKSSEPEPNGSGDWGDYASFVQHMRHISDQKGVDLLVIDSGDLHDGSGLSDAFEPGGINGHDTNKIFTMLDIDVLTIGNHGLYNADVTLDIFKNFAPAWQERYLTSNTNITDPSSNTSVPIGERFLKHYTRHGRKVTAFGLLFDFPNPNWRVQLQSIDDMIKEKWFQEAIDEKPDFFLLVAHMAINDLKWQLIIDTLKSKHPNTPVIGLGGHQHIRDCVYNFKDKRDVRMASGQFLETIGWLSANISDNGEMHISRKYLDANPIGYAWHLGINTSELLTTLGREIKMKIGQLWHKFALGSMVGKLDRDLYLNRVPAEHPDSIIRWLKDKVLPDFVKNEDRKDIPKIILLNSGAIRYDLYSGEVNKNDLFTAFPFVNTLPYVRDVPYGVAKKMLKTLNELPGHPFLTNNNQEEIRLTRTSIGYVTNDTCPGFGDDVIHEKIEYYEHSPCFGTDLEVLEDSDFVDVVFLSFLWPSIEKALNIISPEKQYEFEETYTNLTIREVVSEYLKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCE3</accession>
    <name>I4YCE3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_68899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958330.1">
        <property type="nucleotide sequence ID" value="XM_006958268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCE3"/>
    <dbReference type="FunCoup" id="I4YCE3">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCE3"/>
    <dbReference type="GeneID" id="18475486"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68899"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCE3"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="348"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="634"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="865"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138077" checksum="88DDB1D04A433DE8" modified="2012-09-05" version="1">MLNLLTKFESKSNRVKGISFHPKQPLLAASLHNGSIQLWNYQMGTLVDRFDEHDGPVRGISFHPTQPLLASGGDDYKVKVWNYKTRRCLFTLHGHLDYVRTVFFHHTHPWILTASDDQTIRIWNWQSRTCIAILTGHNHYIMCAQWHPTDDLVVSASMDQTVRVWDISGLRKKNTTAFPLSFEEQIQRANTGQTDLFGSMDATTKFVLEGHDRGVNWVTFHPTLPLILSAGDDRQIKLWRMSDTKAWEVDTCRGHFNNVSSALFHPRHELIISNGEDKTIRVWDMSKRAAVQTFRRENDRFWVLTAHPELNLFAAGHDNGLIVFKLERERPAFALHQNMLYYVRDKIVRQHDLSTGADAALLSIKKLGNAYTPPRSLSFNPAERSVLVASPADNGTYDLAALPRNLPNEDDLADSSIDGRRGTGQNAVFVARNRLAVLNKEEQSIEIRDLSNNLTKSVKCPVQTNEIFYGGTATLLLAGPTQVVLFEIQQQNVLSELTCPPVKYVVWSADNSMLALLSKHTITLANKSLTSSSLIHETIRIKSASFDENGILIYTTLNHIKYALPQGDNGIIKTLQQPVYLVKVKGKTAYCLDRSARPRKIEIDPTEYRFKLALIKGNYDEVLHIIRTSTLVGQSIIAYLQRKGYPEIALHFVQDKSTRFDLAIECGNLDVALEEAKGIDREDVWERLSQQALKQGNHKIVEIAYQKTKNFDRLSFLYLTTGHTEKLKKMQKIADMRGDQMSRFHNSLYLGDAEARARILIDVGMLPLAYMTAKSNGLNDIVTEIAAMDGVDESKLAKIPEGQHNLQPPTVVNKTYEENWPSLSSQESYFDKALEKVLDQGEDVNQLDTLDEWANPDEYAGGVDAPADGAVAEQVEGDAWDLSDDDVPVEEPEEEEEEFVNATTEVTGDITAEEAIAAAPGLSEAEIWTKNSPLAVDHIAAGSFDSAMQLLHRQVGAVNFEPLKPLFMEIYQSSRLFAPTNANQIPINVYLRRDPRTSDPKKFLPSNNTLTLQSIASNELQEGYRLFKAGKFVESASAFRNILVKMLLVSVSNEEEAKDVRDIINVSREYLIGLTLEIERRRLVAEEPSNTTRILELAAYFAECELQSAHSQLALRSAANSFEKAGNTITAGYFAKKLLDLSPTAPNVVAKAKSQVNGAERNPRSTVQIDFDEKSNFHVCPASLTPVYEDQEFVEDTYTGAIYHAKYANSICSLTGINRIGSQSTGLRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG6</accession>
    <name>I4YCG6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Wsmco1</name>
        <name evidence="11" type="ORF">WALSEDRAFT_68917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958349.1">
        <property type="nucleotide sequence ID" value="XM_006958287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG6"/>
    <dbReference type="FunCoup" id="I4YCG6">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCG6"/>
    <dbReference type="GeneID" id="18475491"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68917"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="InParanoid" id="I4YCG6"/>
    <dbReference type="OMA" id="GDWEHHP"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697826" evidence="7">
        <location>
            <begin position="19"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="87"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="227"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="515"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="673" mass="75447" checksum="24BC13D8585D0C2B" modified="2012-09-05" version="1">MFMRDFLGITIASASVLASAVLDSTETDVNLNPKHSDSDSWKVEYDHKHHDYHDDHGYHNKFDIFASPEGNGLGGTLKTFTINITESRKSLTNGSSRFHYEINDQVYGTPIIIDEGDEVEFIIDNYSFTETTIHLHGLLQQLSPWADGVPGVTQSVIPQNKRFIYRTRIMDQHGLYWAHSHLRETYSDGIVFPFYVRPAPDRPKPFSLLTNDSQEISTLEALNDDPVIITLSDYTVMPSNERKVSEFNWAFGFLCYDAIIINNIGRQNCPGSDFLRSLTLSNTTTDKGCLNPNVVTNSTTNFDDDIWFTCNETDTAPPVFEFDYENGWGVIHFLNHADHWDMIISIDEHEVFTFAADGNFHEPLVNDAFILGVSNRMGIAFRLDKPGEYVMRVAAYQDPQIITGYAIIKYGLDQFETTSYTQQPGLPALPDSIPFIDYAGNAVSNDTRIMDNLALRSWPNSLVPKAYEDADVLLRLDLNASGTLFWSIGEQFYDPLLETSQAPVLIHPEYYLGLNKSIAEYPKESVVDIVHVTAPGSPRHPLHKHFEHVWVLGGGVGPFNYSSITEAESAGLPIVWDSPPIRDGWLTFAAPPNDTAWFVVRYKGETSAAVLLHCHILAHQNGGMAYTLAQGPEDFSKVPEYYKLRANGEAPHTPLPFGPDDLTIPVLEEGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCS9</accession>
    <name>I4YCS9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958079.1">
        <property type="nucleotide sequence ID" value="XM_006958017.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCS9"/>
    <dbReference type="GeneID" id="18473828"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60233"/>
    <dbReference type="eggNOG" id="KOG1739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003343_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCS9"/>
    <dbReference type="OMA" id="NERIAHN"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="238"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1301" mass="145432" checksum="8630FF11ECC43A8C" modified="2012-09-05" version="1">MIVTTFYNTKSFVSVATSIDQQSEEPHQYIQIPLFAWSAVFTKSTTKIDHYWQWNLKNQSNTSSIMSNLISLVNNTKDIPFLTSFSDLSISDYLINTQRNSLSFNVNLPNDINDVSPQLNLVVPAEYSWDIHTSSDCKVSVKRYENALSIQVLPIQFSSLSIEKTTGAPSSIRYNGIIKPATNTEDQLLGEALPRSSAHKFHANSIMQELSNVSHQDDLAPSEKPAESSVTNKKNVRTQNQASEIASLIRRNYIYFSSLLQEPEAKWKHISDNKGVSITQLDTIDPTLVLYRAQAIFIGVNIFDIFAVFESYGSRVFWDKTFEDATLLEDINNTSNLWYFKTKPVWPANARDNVLVTTSYKSMSSIHCFGFTAHDTSLFPSIPPMTTNLIRSQTDLSGVAIESLSPTTVQVTILEQSDPKGWQNKSGIPQILTQQLSGIGEFAIKYGGPPILTDITNGRALTSHYDHDKANYKLEYEMILPFDTLVPVQSQEELHPNRTKETFTITCLLRCDLDIWANSIDVIIDPPATDVDCIRRHRLSAKGGGVWITIKHKVDPSNEQYDIFDSKLAVNILKSKKEKDRGNVYVNGIKVPVEVEEISEEAVTKLKAMKRHPPSRVPLDTLAEKQLEVNEIDPVEGWSTLEKKTDESASEAASTTTSKDIPTKYTSKLGNVAETPVQSPSSFKEKSSIHSQSLDQDATTTTKHKEPMRRALDSLSWTRRIHDDLNNSTVTTSSALKSTLSSQKQQLYGSSASTTGSIASNSSNTDLVSAESSKNTNWNVIYEKDDLTIKRKLFHALSNDIPVQVGQRIIEGWSVNEVASAIQSSFLNKSTRDSKTWDNERIVNNLPLEMYTSGSFSSYLTLRTTFPFKDRAFFTSTISSNINGKRYITSASIDPSLLAAHNFNESRLNKSRLPYGKILIDSWVLEEVDPYSTEKLLIPSTNVSHYVAVDYCGNVPSTVNNLCNTLSVKVLNNLDSYLTNNGPPISLLKPIPTFSLNKNSEIPDEVSLREGELSWVIDKPKKGEVSVVLSNKYDGQHNIEFGHGLLSTEEIDRQAGMHKLADKEDTIDDIEIDQLSPTLPERSFEQQQQQQSRNVTPSNLAKRASSMSLKVPTGSNTQMRSISGASTSTIRRSDFRNNFDNLLQALRFGRDYILAELVVDLQLYTGGISVDVQSRVSDEALPLSTTQNTVDEMAIDLNVFNLSSSLDPARVRHKQLLRLVLKCGSLKDSFRVKLLNHHKLVTTLNIKSADELTPTKEVLYNGSSMDVKSEKLSMQDLLDDVKYELLDCIPLSNSRGYCYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCW3</accession>
    <name>I4YCW3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958109.1">
        <property type="nucleotide sequence ID" value="XM_006958047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCW3"/>
    <dbReference type="FunCoup" id="I4YCW3">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCW3"/>
    <dbReference type="GeneID" id="18473839"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60254"/>
    <dbReference type="eggNOG" id="KOG3042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCW3"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="302" mass="33596" checksum="AEECC497842848D2" modified="2012-09-05" version="1">MTRIVSKIAELRQWRVQQLSNRNTVGFVPTMGALHQGHLKLVEESLKSSNNTIVSIFVNPAQFAPHEDLDTYPRTLKRDIEALESLSKDITLFTPNVQEIYPNGIQQDASKQVGAFVEMLGLGNKMEGISRPHFFRGVATIVTKLFNVVQPDLAFFGQKDVQQALILKRMCRDLLVQYPTSQNLKIVPTARDAVNNLALSSRNAYLSEQERTEVAPLLYKALNAAKEAYDSGVRTREGIIDATRPYISLAQQKGAKLDYLEINDATTFEVVNDIGMDGAVLSAAMYVGKTRLIDNILLGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD35</accession>
    <name>I4YD35_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_68788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958178.1">
        <property type="nucleotide sequence ID" value="XM_006958116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD35"/>
    <dbReference type="FunCoup" id="I4YD35">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD35"/>
    <dbReference type="GeneID" id="18475471"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68788"/>
    <dbReference type="eggNOG" id="ENOG502S9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2580463_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD35"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="81" mass="9746" checksum="240398FA4F96A854" modified="2012-09-05" version="1">MVIASFGLSTFTQTKYDRQDSKVKQLDKKEALQIQKNKKPIDLREEYFRLQSKESDLDNWENKRIRRDIAGLDEWNMPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD53</accession>
    <name>I4YD53_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_18071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958024.1">
        <property type="nucleotide sequence ID" value="XM_006957962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD53"/>
    <dbReference type="STRING" id="671144.I4YD53"/>
    <dbReference type="GeneID" id="18470751"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18071"/>
    <dbReference type="eggNOG" id="ENOG502SEUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140754_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD53"/>
    <dbReference type="OMA" id="TIVRMLI"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="15688" checksum="F673C23DFE824CF3" modified="2012-09-05" version="1" fragment="single">MNFRSPNKIESKYGVVSDYTNLNLHQAAFTNDVGSAAFALRNGQPQNSVYKGTLPIHAASLAGSRDVLRMLIDAGADVNAPRLPKHVGAPKESHLHHHHEHNPPGTTGSTALHFAAAGGHLQIINILLDNGADPNKVDKNGQVPATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD55</accession>
    <name>I4YD55_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958195.1">
        <property type="nucleotide sequence ID" value="XM_006958133.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD55"/>
    <dbReference type="GeneID" id="18471490"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32440"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002459_2_0_1"/>
    <dbReference type="InParanoid" id="I4YD55"/>
    <dbReference type="OMA" id="PRGGPNM"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MI" evidence="9">
        <location>
            <begin position="1198"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1334" mass="144967" checksum="62E2C5F819B486BC" modified="2012-09-05" version="1">MSQQPKFNYAAAAKAKQQQREMAISEKQPPTKPKETKPAEAEKADKTDKSDKTEKSAPSKQKKEFNPHAFFTGGGASTQPPQQSQPAKAQKQQSGPNNNTRNSDSLRLNAQPFNPQHQNYRPPQSFQPRGSMTQNSASRPPQQQRSPQPPQQQLGSQPYYTPAYNTTGYYDPNMGIYVPFAQAPAAGWSQYPPQMPPTSPSAPQVSLPATTAPAAANAPRNGPSPQNIPTTPRVSSSNASPRPPFTPSANAPIFSPPQSTTTSPPPTSGMSPSAASFMPQRKSAAIKISNAQGEKIDLTSFKHQRQSSSIPSIASVEASAPDPSTYVKPPPRTAIRLESEEAKAKRLAEEAKQTDSEEKKKQEKANEERIETSRKEEEKKEAEAEEKKRQEAAAEKAKAEEKLAAEEKAKADKEANAEKLAKEQAALLAKEKETTEGTTPGTSLDQAKVEISKDEQQKELISKIAPATDELATPAESDKQLPKIDTSSPTVGEEEKPAAASPSTSTQKPSQALGAARRIDDLTKISYPGDIKSPKAELNKQARPGKFRYDRDFLMQFMSVFTDKPASMPSLDAIGLEPDQGMGFGGRSSSGRQGSRGGMGRSSGFGKQGGFGQFSDVSSRGTSSAERFARSQAAGAFAGQPMSRTNSSHRGMAREASGGGRNRSQRGKTRDGKGGQSATPLADAMGSVAPLEKSENAWTPQALRNRAQGVRPGLNVDENDPAYIEKKVKGLLNKLTIEKFEPISDQIIIFANKSENEDDGRTLRLVIKLVFEKATDEAVWSEMYARLCRKMYDQLSANISDKDQPTTTTGGRLFRKYLLTRCQEDFEKGWSDKAAASKAAAEKAAEDDAKRQANEEAEADIAKGGEPKADAQSLSDEYYAAQKAKRRGLGLVRFIGELFKLTLLTAKVMHLCIMQLLQRDDTKEVEEEDIESLAKLLTTVGGMLETPEAKRHIDSYFSHMQDIVDSPKTSSRLQFMLLDVIELRNHNWVGRHKDAGPKSIAQIHRDAAKQRAQSAADANVALQRGSSGRGPARQESSRGPSRRGQPRAPAVPEEKGGGDGWNTIGSGGNQKTSQVAGNLSQFGQFSSKGAQQPQQSQQSQFGPTSVFTKKGRQGGSGGTSPSGVASPLLSEGKSPAVSRTNSSGNMFSLLEAQDQAQHEEQPQRKKLNLLPRSSTKTDVEEPEPAPAAPATEEITDEKAKQMVKTMIEEFYSLKKISEGLESFKELPEEHKPKLIEQLIDRSLNGKKETVDITSELITAAVEQELVAQTQLETELVNILEFIEDISIDVPNAYEYSASLIKASKFDSNGIDRLLAKIPKSDSITQPSDKVKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB5</accession>
    <name>I4YDB5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957769.1">
        <property type="nucleotide sequence ID" value="XM_006957707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB5"/>
    <dbReference type="GeneID" id="18473746"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60108"/>
    <dbReference type="HOGENOM" id="CLU_1526362_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDB5"/>
    <dbReference type="OMA" id="MRIRANY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="20119" checksum="B9D92530CAECE0C0" modified="2012-09-05" version="1">MSNIKVEICKTQAEIEEAFNIRLAVFTKEYDQVANELIDDILDNHAIQLLARDEDGSAVGSVRLQPYPQDIEKLEARALRPATEEETVKLFDGIEGGRFANLAVKPSARNKGVAATLIKFCEDYIKARAKPGTSYIRFRSHYRIHPLYIAKFGYAVDSERFTTSWNQDLVWMYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDC0</accession>
    <name>I4YDC0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_32176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957774.1">
        <property type="nucleotide sequence ID" value="XM_006957712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDC0"/>
    <dbReference type="FunCoup" id="I4YDC0">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDC0"/>
    <dbReference type="GeneID" id="18471436"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32176"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="InParanoid" id="I4YDC0"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="400" mass="43917" checksum="E0870CC36ED34FE0" modified="2012-09-05" version="1">MVAERKYYDLLDSQPDASQADLKKAYRKKALRLHPDKGGDPDLFKEVTHAYEVLSDEDKRQMYDQYGEEGLQGDAGMGMDPGDLFSQLFGGFGGGRRPTGPRKGKDLVHRLGVSLEDIYKGKTTKLALNKNTICTGCEGRGGKAGSVKQCTSCHGRGIKVTLRQLGPMMQQVQQQCDSCNGQGEEIPAKDRCKTCNGKKITSGRKTLEVHIDKGLKNGATIVFNGEADQAPGIVPGDVVIVVEEKPHNIFKRKGNDLFAEKEIDLLSALGGGSFTIPHLDDRLVKVTWQPGEVITPESLRKIPKEGMPSQRFHELGDLFVHVKVKFPESIDPTLVPHLEKALPPRNLPEEDNAMHVDDVAFEQLSAGQQAEQHHRPDSMEEDDDDDMRGGAGPGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDH6</accession>
    <name>I4YDH6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FolC bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_54229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957826.1">
        <property type="nucleotide sequence ID" value="XM_006957764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDH6"/>
    <dbReference type="FunCoup" id="I4YDH6">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDH6"/>
    <dbReference type="GeneID" id="18472658"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54229"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDH6"/>
    <dbReference type="OMA" id="SIHDRIC"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="7">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="404" mass="44602" checksum="22F9E851007995C6" modified="2012-09-05" version="1">MIKLGLEATGKSLLKISNQSQPIVHIAGTNGKGSTSAFIDGLLRSLDYKVGRFNSPHLVEEFDSLIIQGKPISSTVYYNLVHQLETQDDNYKKLTNFEKLTVSAFNLFSQQEIDVGIIEVGMGGLLDATNAFSREYRDSIAVITPIALDHISWLGDNIIDITKQKIGIITSKTKAAIVAPQIHHQVIGLIRERCEELKVPVYFNDRPGELVNPINGDIINAQLRMAGKHQIENASTALLAVHALQKHCEHFKAIDLSANNEISNTLNQVSFHGRSDRDVLPGVIVDGAHNPAAMQLLRDTLSEDQAYTFILGFSQDKDVDDMLRILIRARDTVIFVPFSSIPSMPWVKNMNTTTLKAKTDELFENSVDVSVSNNLPEALQLAGKSGKKVVITGSLYLIADVYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL9</accession>
    <name>I4YDL9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957865.1">
        <property type="nucleotide sequence ID" value="XM_006957803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL9"/>
    <dbReference type="GeneID" id="18475418"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68540"/>
    <dbReference type="HOGENOM" id="CLU_1125262_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDL9"/>
    <dbReference type="OMA" id="FTWEIIS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="247" mass="28800" checksum="7284EA232E443889" modified="2012-09-05" version="1">MFPSKSVHYIRLNESSALQCVVFLDSKHRAWFNRRILLNVIEDVKRLYMPKLLAEMQHGREELDTYRNNGYQFAYYYKPTREKQGVIKKTRQVRYIPTSKRTVQQTTDEEDLFIDDDDLQYEQKPKPKVETSYKMLKLFAKTLHVIVQPDQATELQPSILPSPEPEIVQIEDNNQTNLSEVLQPSEDVKPDINELMIPNSQELPSSTQAALNDFNFDASSSLMLSQMLQNGQFGNRMVDNDDDNVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW4</accession>
    <name>I4YDW4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957956.1">
        <property type="nucleotide sequence ID" value="XM_006957894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW4"/>
    <dbReference type="STRING" id="671144.I4YDW4"/>
    <dbReference type="GeneID" id="18473799"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60184"/>
    <dbReference type="eggNOG" id="KOG4069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117313_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDW4"/>
    <dbReference type="OMA" id="FIYICTE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="164" mass="19324" checksum="CBFC2E544000653D" modified="2012-09-05" version="1">MGDPEQQVMRSRSPASLISGDSSNFNVRLKNFGTAPERRVCIDLPREVVRVDRDYQFGEIWQFARSFPMELEGRLNPEQYHFAIHEINYQLSRAFNPWYAVLDHLCDIASFYTLSLFKRTYFEKRISELEGTLNYLNYNLFNPAGLNILNPSIIGFLYLEIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW8</accession>
    <name>I4YDW8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_32291</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957959.1">
        <property type="nucleotide sequence ID" value="XM_006957897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW8"/>
    <dbReference type="STRING" id="671144.I4YDW8"/>
    <dbReference type="GeneID" id="18471458"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32291"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="I4YDW8"/>
    <dbReference type="OMA" id="GYFRLAM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="370"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="699"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="988"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1237" mass="134630" checksum="43E1535DFA18A66A" modified="2012-09-05" version="1">MRSAKKESVTTMMKKATYATKGEIMLNLVGLFFACGAGTTQPLLSLIFGRMVSTMITFFQVSKLYKANPSDPELTQVFNSAKDDLNDDVSMNCIYLVVIGVAMFIGTYVYTLIFTYTSERVSRRVREMYLRSILRQDVAFFDNIGAGEVATRIETDTHLIQMGVSEKVGTAAMYIAAFITGFIIAFARQARLAGVMFIIVPCIAALGGLLTTFTSKYEARSLDNIAASGNLAEEVISTIRTAKAFGSQLLLGTLYDAELHKARKTGYKVASVNALVWTSVFFIIYCSYALAFAWGVTLVLKDETEVGEIVGVLISTMIGSFSLAIAAPELQAIAKGQAAAAKIFDTIERIPPIDSASEEGLKPSFIAGNITFEDVDFSYPARLNVQVMKKFTATFHKGHLTALVGASGSGKSTAIGLIERFYDPLNGVIKLDGNDLRDINVKWLRSKIGMVGQEPVLFNETLRANVEHGLIGTEMEHWPDEQRLELVINACKVANADGFINTLPEKYDNSVGERGMLLSGGQKQRVAIARAIVSDPPILLLDEATAALDSASESIVQKALDKAAKNRTTIAIAHRLSTIKNANQIIVMGGGEILEVGDHNSLTANPDGAYSTFVAAQSLAQAKDEEAAQVNSDVVEKNDDLHEDVIPLNRVKSGRSVTSQILEKSNEEKVEKEHHYSMFEVIRRLVKMNRPGWSAYTSGSIAALVTGSAYPIMGILLGRILQHIAARSPTDPDYHSYIRHQIDRDSLWFFIMAIGAALGILIQSWAMHYAGELLTYALRHESFKKLLRSDVEYFDKKENSTGVLTSNLADNAQKVQGLAGISASTIIQSCSTLIVGVAIGIGYNWKLGLVGTACIPLTLSAGITRLKIVVTKDQQNKKSYEDSAEMACEAAGAIRTVASLTREGQALEEYQTLLRTPLRNSIRTSLWSSAIYGLSQGMAFLVFTFVPDVSNARGGAARILKLLDTKTEIEIETTSQDGIHLDTVEGHITFEDVHFRYPTRSDVPVLRSLDLEIKPGSYVALVGPSGCGKSTTIQLIERFYDPAYGSVKLDGHEVRDLNLNNLRSHMALVSQEPTLYAGTVKYNILMGAVKPHEEVSQQELEDACADANILDFIKGLPDGFETQVGGKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDQTSEAVVQAALDKVASGRTTIAIAHRLSTIQKADRIYVIKDGKVSQAGAHKDLIEQKDGLYAELVALQNLSSQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE82</accession>
    <name>I4YE82_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_44633</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957537.1">
        <property type="nucleotide sequence ID" value="XM_006957475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE82"/>
    <dbReference type="FunCoup" id="I4YE82">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE82"/>
    <dbReference type="GeneID" id="18472338"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44633"/>
    <dbReference type="eggNOG" id="KOG2805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_1_2_1"/>
    <dbReference type="InParanoid" id="I4YE82"/>
    <dbReference type="OMA" id="LFMRNWN"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="272"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="353" mass="39830" checksum="63063FE6952D90D8" modified="2012-09-05" version="1">MSGGVDSAVAAGILVNQGLDVRAVFMRNWDTKDELSLSTVGGVKGCEWERDWEDVKRVCHHLNIKDLKLVDLSKQYWYDVFEPSLDVWRDGRTPNPDIGCNKHIKFGALLDLVLKNDDMLATGHYARILNNHLCRGRDRLKDQSYYLSAIQRSVLDRVVFPLGTLEKSHVRSLARELRLPNAEREESMGICFVGERGNRFGAWLDDYVDNVPGYFLTEDNKPIGKHRGVHHYTIGQKAGIGGMPSKMFVAAKRDTDIIVVNNSQHDLLKCKKIFTLGDTNWLADIPAKSFEAHAQVRHRQQETRCTVEVVDNKLEITYQEYEMAVAPGQVVAIYVGDICVASATIDKTQSIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEJ6</accession>
    <name>I4YEJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Breast carcinoma amplified sequence 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957638.1">
        <property type="nucleotide sequence ID" value="XM_006957576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEJ6"/>
    <dbReference type="FunCoup" id="I4YEJ6">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEJ6"/>
    <dbReference type="GeneID" id="18473705"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60045"/>
    <dbReference type="eggNOG" id="KOG3096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082523_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEJ6"/>
    <dbReference type="OMA" id="SAWQESI"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24167" checksum="7A836D8CDD4CBFB3" modified="2012-09-05" version="1">MATKEDYKLDSLPYYDKELENDTKLRDAAAKLIADELANSESRDLSGELGDDISTGFLTSSDLLRQEMERAGKGIQLDSFDASRYALAEPEVENVSEWKKSYNNAVIASEYQQLRSSNLDLLSALGANAWKLSNHTLDADARSLEQQSEQINNKIIDINRLRKSEQTKIGENLNTLEKSWGGLVSNNLELEVATIALEVELAQLAEREQQLRASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW2</accession>
    <name>I4YEW2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957177.1">
        <property type="nucleotide sequence ID" value="XM_006957115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW2"/>
    <dbReference type="STRING" id="671144.I4YEW2"/>
    <dbReference type="GeneID" id="18475325"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67979"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_2_1"/>
    <dbReference type="InParanoid" id="I4YEW2"/>
    <dbReference type="OMA" id="WAQRTIG"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="30683" checksum="4EADCBA6CE2FE2AD" modified="2012-09-05" version="1">MQIHSNTFIVTGGVGGCGKAVAKAILEKDGYVVLFDIVKAEVAIPLAQQISKDRALYIQADITDEDSTKKAVKAASNAFEKKLVGAVHCAGIAVRQPWSPIVSDSIPNFRNALNVNTLGTYILNAVVADAINERHEPLKYASKGFFKTKEERGAIINFASVSGHDCYARNLGYGPTKSAVLGITRTMSDFLGESGIRVNSISPSIINSNITGPVFPYFLSELERSSSFPARAIEHDEIAGTVLFLIENGMMNGQDIRIDGGWRLVTDRHPDRPDYRTLAPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX1</accession>
    <name>I4YEX1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_31760</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957186.1">
        <property type="nucleotide sequence ID" value="XM_006957124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX1"/>
    <dbReference type="FunCoup" id="I4YEX1">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEX1"/>
    <dbReference type="GeneID" id="18471363"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31760"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEX1"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="140"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM22513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="952" mass="101758" checksum="9DFCB58DE86934DF" modified="2012-09-05" version="1">MVGQKIDGTAIAKKLRGDLATQTKTLPFQPHLVIIQHGARPDSNSYIRMKRLAAEEAGFKFTHIKIPETESVDVVLDHVRRCNQDDGVHGLLVQLPLANGGKDGERKVVETISHDKDVDGFHPLTAGALSSRLSDPLFAPCTPAGVIKLLEESGVEIAGKFAVVLGRSDIVGTPAMNLLRRKDATVVQVHSKTKNIPELVKQADIVVAAIGQPEFVKGDWIKPGAVVIDVGANFVPDATKKSGQRMLGDVEYSKAIENASHITPVPGGVGPMTVAMLMVNTFRAAERQAKLRGGRGRGVVTPLPIQPLEKVPSDIEIAMAQTPKPVSTLAKEIGVLEEELELYGQSKAKVELSILDRLQHRKDGKYVVVAGITPTPLGEGKSTTTVGLAQALGARLGRSTFACVRQPSQGPTFGIKGGAAGGGYSQIIPMDEFNLHLTGDIHAISAANNLLAAAIDARMFHESTQTPKALFNRLTPAKKGVRTFSPVMIKRLQKLGINKTDPKDLTEEEAAKFAKLDIDPETITWHRVTDTNDRYLRKITVGQAPTEKGISRETGFDISVASECMAVLALANDLPDMRRRLGDMVVASSKSGETITADDIGIGGALTVLMKDTIKPNLMQTLEGTPVFVHAGPFANIAHGNSSILADRVALKLAGTEEGEPSSAGGYVITEAGFGADIGMEKFFNIKCRVSGLVPDAVVLVATVRALKMHGGGPEVSPGKPLDDIYTQENLETLAEGCKNLAKHIENGRKYGVKVIVAVNQFSTDTPAELELVQKLSLEAGAHAAVASNHWALGGEGAIDLAQSLIDTCEPKNENGEVLPAASNDDFKLLYNDDLSMEDKILTIVKEMYGGDAIELSDLAKSQVETYKKQGYGNLPVCMAKSHLSLSHDPKLKGVPTGFTVPVRSIKLSAGAGFVYALCGEMQTMPGLSTRPGYYDIDLDLSEDKPRVVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF08</accession>
    <name>I4YF08_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_63189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957220.1">
        <property type="nucleotide sequence ID" value="XM_006957158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF08"/>
    <dbReference type="FunCoup" id="I4YF08">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF08"/>
    <dbReference type="GeneID" id="18474818"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63189"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF08"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="114"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="199" mass="22016" checksum="0175BD4F26C005B3" modified="2012-09-05" version="1">MSPSRVAWRPLTEDETRAVFEKLANYVGKNLVHIINPSGASSKEDVEDDEDTAPLLRLQKDKVFLLNTSINNLATSVARPNLISLGQCLGKFTKSGKFKLGIGSLDVLARWARYKVWVKPNGELPFLYGNHVVKAHLGRITEDTPEHQGVVVLSMSDIPLGFGVSARSTVDTRKLDPTGLVVFHQADVGEYLRDEDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF55</accession>
    <name>I4YF55_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_56786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957266.1">
        <property type="nucleotide sequence ID" value="XM_006957204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF55"/>
    <dbReference type="FunCoup" id="I4YF55">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF55"/>
    <dbReference type="GeneID" id="18472854"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56786"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129470_4_0_1"/>
    <dbReference type="InParanoid" id="I4YF55"/>
    <dbReference type="OMA" id="RIVHHSG"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="104" mass="11436" checksum="0D6681D832AE9FCA" modified="2012-09-05" version="1">MAKKAAAAANPSAGKGGAKSKKKWSKGKVKDKAQNAVVLDRPTYDRILKEVPTFKLISQSTLIDRLKINGSLARIAIRHLHREGAIRQIVHHNGQLIYTRSGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFD1</accession>
    <name>I4YFD1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957338.1">
        <property type="nucleotide sequence ID" value="XM_006957276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFD1"/>
    <dbReference type="STRING" id="671144.I4YFD1"/>
    <dbReference type="GeneID" id="18473607"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59885"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015532_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFD1"/>
    <dbReference type="OMA" id="GFLFHKG"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="643" mass="71731" checksum="0397BD752BC89F93" modified="2012-09-05" version="1">MKRLSGYFQRDLSRRDNESLNQRYHLGFASHYKSLQPHEKTTFQSTEIFIGFLENSEINTYDRDVFLRILLLDLRPGGVSDKWDIQTALSALKVIKVLGRSSIGTTALTTIDAFNCLASLLERKGYNESTATTPSLTSRLQSHRASYITSSDTISVSECHLESMTIVANTLLLHEQARYNAVQSNIPSLCYQALKAQQNTSDIHFVAARCLFLCTLKPDPVVTKLVHEDNLVDVIHARLIQYTPYIIPSNKSNDIPPRSKELVTDILKLFFNLTLHHKSSNSSPILGENWDEKFSKLLQPLLILFMDLTGNSNVNAISPIPQPIPQVIHSLLCFPFKPFTQIWSNPHSSGSFSPSAAINRLSRSLSRASVVQYDTSKLNFENMDNYPLLNRLIELLNNVISAFWPSSSLEGGESVDSAQAKTKSAGVGINLDETLSPLIMLLRKLVAEDTRGNGGFKGSLWRLLGLHDIDRSVKMEQRGDSLGVFVRFLTSSLFPSIKTTVGELLFALCDNDPTKMSSTIGFGNAAGFLFSKGLLSAGAGDPAETGVNPVTGAYEEARSGGPEEMTEEEKEAEAEKLFDAFDRLNRNGIIKTSNPMQDPKNQARFQEIEEEEVDELKKQDEQDEEDVEQMMKEYKSRKDKSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFL0</accession>
    <name>I4YFL0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">STE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_68178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957409.1">
        <property type="nucleotide sequence ID" value="XM_006957347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFL0"/>
    <dbReference type="STRING" id="671144.I4YFL0"/>
    <dbReference type="GeneID" id="18475360"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68178"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487627_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFL0"/>
    <dbReference type="OMA" id="FRYGAIR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="521" mass="59902" checksum="E9A1C1FB56893F8F" modified="2012-09-05" version="1">METEIAGPILSLNAFLIDAPNKFNSEQETDDLHPHRIIHRYKLDDVYISCIRYSDDFFITGPDIYKIISFKVRKLGRIITDKRKFNEGISSDLRNLKIGIDSVIEYNGSTLLDLLVRFGALRTLKKQKLFKWHSVPHDRMFLDALERDLKREAAGTPGTSTAIDPASFALRYDRDVSLKQQFYDQGLADIFLLRINNGSEFYKQGKSLKKLLQKRSAVRNEKDDISLLNEIDNINLSEKRAFKCDICDKAFKRDEHLRRHKRSHTKERPYVCEICHKSFTRSDNLAVHFRTHNSNVSKPVMYTDSSDAYSECSSTYMSSIASSDSASHYSSRPSTATHWTDSPNHILDHQVLLPFSQSYEPSSGPMRRHRSETPSCLNLNGNSSFYGSSLPTYSMTTYDPIENPTERLDLDYNYAVPRTAQSLPSFDDNRLQPLPYTVETHAIPTMVGDICEDDFRTPTESQFAYQPPPIPMDNIKTPTESQFRYQVPSVNIENNQGMINQPEPTYLPYQYYNTYDGFQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFL6</accession>
    <name>I4YFL6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrp15p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957415.1">
        <property type="nucleotide sequence ID" value="XM_006957353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFL6"/>
    <dbReference type="STRING" id="671144.I4YFL6"/>
    <dbReference type="GeneID" id="18474837"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63387"/>
    <dbReference type="eggNOG" id="ENOG502S6W0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088030_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFL6"/>
    <dbReference type="OMA" id="DFFNMIR"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27034" checksum="71FB1F7E44D6F98D" modified="2012-09-05" version="1">MPSSTKSSVGKADKAKKPAAEPKSILKNKKSDEVEEPSSEDDDEGEEGDEEVESDDENDSDEAPTTDYESDYNGLQKKPKKRKRNEGEAFAEALSNLAEADSKKLEILPAANKSLKKHKLTLKAQKVLRDEAKSDQDIGRLRDVVSGWAVPSTKKDKLDDESALVDAGAEKEKRLRKVAQKGVVKLFNAILAAQKAESGAKVSEKEKDKGIGRARLEAPANFPRENKGKKNNDNVAKNAFMDAIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFR9</accession>
    <name>I4YFR9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956864.1">
        <property type="nucleotide sequence ID" value="XM_006956802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFR9"/>
    <dbReference type="STRING" id="671144.I4YFR9"/>
    <dbReference type="GeneID" id="18473463"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59626"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFR9"/>
    <dbReference type="OMA" id="ITEWVFM"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000363">
        <property type="entry name" value="D-isomer specific 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="117"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="39195" checksum="B720E389B13D6996" modified="2012-09-05" version="1">MAILLSTISPPLSQDNIQRLKEHFDEVHSFPNNKDVPIEIINRADVYFCLKRGLPEGVSSFKDFKSLKLIQLSCAGANDLIDNPSFAELTNSNDLNIVVSNASGLHVTCVAPYAIACILNIYHRLPEQLLNQVNKQKWIDDLPDHHGNRYKVRSLRGKTVGILGYGHLGRECARLLKTFGCRIIAANTSGERTQDSGFIIPGTGDFDATIPEKMFSSKDGNSLREMISESDILISSLPWTKQTTNILNADLLCLLNQDGVFVNIGRGNVIETSELMKALNEGSNTISAALDVTDPEPLPNGHKLWTHPRVLITPHLSGEAELEFELATDILIENIKKIKTSQEIINRVDLVKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFT3</accession>
    <name>I4YFT3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribokinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956877.1">
        <property type="nucleotide sequence ID" value="XM_006956815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFT3"/>
    <dbReference type="STRING" id="671144.I4YFT3"/>
    <dbReference type="GeneID" id="18473469"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59637"/>
    <dbReference type="HOGENOM" id="CLU_788019_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFT3"/>
    <dbReference type="OMA" id="CDYVVFS"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39106" checksum="3FE41A9A7FA6B8BA" modified="2012-09-05" version="1">MGRILKVLSAGNLEFTTTCSTSSYPKEGSKVKSKSQSSTIQGASNILIGLNGLPDTKTFVYSQLGRDLNSNCVKAQLEDEGISTEHIHKSDSGGVPHTFIIHNTSNNMTTRFNHSNSNSNTSLPPLEFLDDVLQRSSFDWVHFDGQTTANLYETMKYIRGNKYLSGLDVTLNDQATISISCFSRLKPDIEDCLPFADVVYFNKEFVNKSGFDDARTFLLFMSLRVSKKANLYCIWDERTTYMLSLKTSEFIRAESSRRPRTHSRTRSYTSSNSIDEAFVAGTIYGTLAKAISTSGHLNIKFDNQKILQFATDMLGLKAAGVPLKDLGGILIKEGWFIDFNNGIYSSDSEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ1</accession>
    <name>I4YFZ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956932.1">
        <property type="nucleotide sequence ID" value="XM_006956870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ1"/>
    <dbReference type="STRING" id="671144.I4YFZ1"/>
    <dbReference type="GeneID" id="18472823"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56566"/>
    <dbReference type="eggNOG" id="ENOG502RZBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493644_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFZ1"/>
    <dbReference type="OMA" id="RWKENAR"/>
    <dbReference type="OrthoDB" id="2563978at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="552" mass="60217" checksum="FF5DFFED3BABC7FE" modified="2012-09-05" version="1">MTQQPLPNYLSYSQILGQDVYTIVQLPQTYYGPSIPLGDGWSYGGLSSPTASSTSTSSTSSSSTSTSTSSSTSSSTSTSTSSTSSSSSTSSSSSSSSSSSTSSPEPPIDRGAGTDTSKILAIVLPVVLGTLLLLLLLLLLLCLLRRRKRQKEIEERQFEITPFLGTHKARPSDAEFTRDNSNSFSRTWTALMGNKYSWGSKKQNKFTTIPPPHSRGFKTDLSIEEKITPVQRQLSSSHLAVADPNAHRPASRMPSKSSIITYDNQSQKYTSPLDKIRKMRLSLLSNHTANDNDDENDGPSTSAGIWGLATSVFPRRSMRPQPPLSGTVGKRVSPHKRQDSDAYSVSNDDSSSSTNPFFAYIPTPRIDDFYDTSMSTTNSKAFTDSSNGGSFHSSSPIRPPFAYRNHGATPSSSPSMSSLSQITWLNTVERNNSNNPDSSVNSPVSASFNTATEGYDSSRNSSTRSRSTVDSDNGSRPPVFPRTSDTVFGRIIAERESAHDFGPPRNDYQPVIVEEEEDENTTLDEDARREEAMSLKSPKWKQNARSFLQRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG23</accession>
    <name>I4YG23_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_67802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956961.1">
        <property type="nucleotide sequence ID" value="XM_006956899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG23"/>
    <dbReference type="STRING" id="671144.I4YG23"/>
    <dbReference type="GeneID" id="18475301"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67802"/>
    <dbReference type="eggNOG" id="KOG0090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1455463_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG23"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="186" mass="20615" checksum="E09D7AF6D4B8F3C6" modified="2012-09-05" version="1">MTIIVSVALSLLAILISVLIYSRRTEKPKDILLAGPSGSGKTAITFALLNTSANSRASTIPNVINHEGTRIVEIPGHERISTDTLKTHLPAKRVLYCMDYKHLNQSVQHLSGFLQAVGNTPVVIVLTKYDKQSQESLIQRSKNTLEFELNKIRKSKVDNDGKTIALNYPFVVVGSKDISNLFEYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG33</accession>
    <name>I4YG33_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956971.1">
        <property type="nucleotide sequence ID" value="XM_006956909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG33"/>
    <dbReference type="GeneID" id="18474800"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62944"/>
    <dbReference type="HOGENOM" id="CLU_1448781_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG33"/>
    <dbReference type="OMA" id="SMAGTIW"/>
    <dbReference type="OrthoDB" id="3360826at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20481" checksum="A94B86C2E76A003A" modified="2012-09-05" version="1">MTSTDAKKKDDTATQSKGLSKASIAGVSVLAFVCVSASMGATIYRSMRARNKARQALIDFRSNYHIEKKPAPMPSSLRSHPTLDNSGGVLKEDTGGHFTYGDAAKSLGIATAIVGTLAGVSGYYLINQFNLSNIEDTRTKLNGLIRTHFKTLYESIHKGDNEEDDIPEDAREFAQQFYDEPNNDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG53</accession>
    <name>I4YG53_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956990.1">
        <property type="nucleotide sequence ID" value="XM_006956928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG53"/>
    <dbReference type="STRING" id="671144.I4YG53"/>
    <dbReference type="GeneID" id="18473505"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59700"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477518_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG53"/>
    <dbReference type="OMA" id="NHYHDLV"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="3">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="526" mass="58381" checksum="B48208D789E5D8C4" modified="2012-09-05" version="1">MTTSIKDIVNSFNKAQQEGNNNNTNTNTSDEPTTSSLTSQTASNNMPFLEFAKKFKSLAHNGLTEDDIAFLQTSLNMDLHRGIGMFITTIHNQHTLNWVKALSESSAKEPTGAGTTAATTSATTSASTSSSQPSQHDIQLRILNQYQQSLFYAFNTSIEHLHAFDEKTAELAEHILIFSEILKKEKTSLHPLKHLLTVFTNGNTNELTPLHKLFVKACITSNLPSYALPVIERGINELAISYSHLTANDNLHYFTGSATLFIMLERYEDALDVLEQIVTLPITTLAVNPMILRAYKQLILLQLIVNGQLSPLPKYTSGNLNKSLKKHASGYHSLVEIGAKATEQPNSFNNVEQTLNHTMEVLRKERASFTKDNLLDLALKAEDSVFAAQISAYSMIYTAMPISDLANVLGISSDHNDQLINKLGEYIHNGAVNAQLNLVENVIEFASKGEKGKSEEELMIDLENAIKGSLSLRSNMQELDRKLTLNPAYVKHHIQKSERKKKETKDEQHSDTPADEMDGMDMSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG71</accession>
    <name>I4YG71_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_31628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957008.1">
        <property type="nucleotide sequence ID" value="XM_006956946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG71"/>
    <dbReference type="FunCoup" id="I4YG71">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG71"/>
    <dbReference type="GeneID" id="18471339"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31628"/>
    <dbReference type="eggNOG" id="KOG2583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="InParanoid" id="I4YG71"/>
    <dbReference type="OMA" id="APKFALY"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="159"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="404" mass="43399" checksum="174AEF5120A6D0BD" modified="2012-09-05" version="1">MNRSLALNNNLKSAFKPSLAGSLNVVFNAGTRFEDNQGVANVLKNFAFRNTAERSSLRQVREAEAAGGVLYSTLTRDNLILSADFLPQHQELFVQILADVVKSTKFTQHEYDEAVKPALQAEFNAAQQNALIQAIDTAHTIAFRRGLGNSLFSASEHPVKLEDVKAYASKVYSADNVAFLSTGPSDISSSLSKYFSGLSSTGQAQTQKSQYFGGEQRLNLPHEGHALPSAFISWGSTSSSPAHTVLAELLGSGSNIKWNKGLSPLAAIEEADVKAVNFEYSDASLFGFAVQSSSESNVKKASQKAVEAFKKIAQNGVESTQLQAAIAKSKFNYTLYADSADGWKQINGNGLINNNLKSLDQVLGEFDAVSTSSIQQAAADLLKNKVTLVTVGGRELPYADELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB9</accession>
    <name>I4YGB9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957050.1">
        <property type="nucleotide sequence ID" value="XM_006956988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB9"/>
    <dbReference type="FunCoup" id="I4YGB9">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGB9"/>
    <dbReference type="GeneID" id="18472835"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56661"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074896_0_2_1"/>
    <dbReference type="InParanoid" id="I4YGB9"/>
    <dbReference type="OMA" id="QSNWGGP"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21699" checksum="73A6185957ED2CCC" modified="2012-09-05" version="1">MYNFADPTDYTRIFARSTISILHLWHALKMAVAESWGGPESEAKRIWLIGVVVDMYEERPPNNQNGSIGGLDYIDTEEILSQAFFDEFGAHLEDGSPRDIAGQLRKAWAEAVVGDMSYSNELYGKYEKEKNKKVSGFTRGEDEEIPYYSDESDGEDEHMQDTQPAQPAQPKQPKPEKIIDDDGFEVVQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGL4</accession>
    <name>I4YGL4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957139.1">
        <property type="nucleotide sequence ID" value="XM_006957077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGL4"/>
    <dbReference type="FunCoup" id="I4YGL4">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGL4"/>
    <dbReference type="GeneID" id="18473555"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59783"/>
    <dbReference type="eggNOG" id="KOG0258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014254_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGL4"/>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="108"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="497" mass="55414" checksum="C351E9EEA2EA8D33" modified="2012-09-05" version="1">MITRSIRVNRTINRSITTSSVNSIRLDNSTINSKVINAQYAVRGEIPVKADIYGQQIRDGNGDKLPFKAIMPCNIGNPQQQGLNQKPLTFWRQVAALTECPELIDNTQLFPKDVRDRARELLNEIGSVGAYSHSKGVPFIREQVAKFLEARDGYPSDPENIFLTAGASGGVSLLFHLLLSGDPDGVMIPIPQYPLYSASLALAGSRTIQYHLDENRGWELNMNLLEKSFNDAQSQGTEVKALVIINPGNPTGAILSEENMRDIARFAQKHELVLLADEVYQSNIYDKNKPFVSFKKVIKDLKLDDLQLASFHSISKGFSGECGRRGGFVEYVNFSEDFLTEATKLASISLCPPLQGQIAVDLMIRPPKEGEESYEQYRKEKDEVLASYASRSKLLAERFNQMEGVSCNNSEGAMYAFPQIRLPQKAIDAAKKQGKSPDSFYCLELLDNTGICVVPGSGFGQAPDTLHFRTTCLVPGTEDYINTIEKFHKEFMNKYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGR9</accession>
    <name>I4YGR9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956557.1">
        <property type="nucleotide sequence ID" value="XM_006956495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGR9"/>
    <dbReference type="FunCoup" id="I4YGR9">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGR9"/>
    <dbReference type="GeneID" id="18473370"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59471"/>
    <dbReference type="eggNOG" id="KOG2752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGR9"/>
    <dbReference type="OMA" id="GAMVYNH"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47535" checksum="3CB74C0DB5B25ABE" modified="2012-09-05" version="1">MTSITTAEDYIREQEILEAEARELLPFKADLCTQDYDKNEIGKPLRQAIYLCKTCGLDKGVCVGCSIICHGDHDLLELFPKRGFVCDCPTSRFSKECSLKKLKATYDSHPNHYNHNFQRRFCACDQIYEPAECDQEMYQCLSCEDWFHEGCLNLRDKNQEGRVNDENSEDAGPVLRLPRSKFDAFVCSECVLSPDLEHLRRYAGTPSFVLLESMKSLPQEGDDDESAIPLKFSNKREHSEDDDYEENDVKRAKTGENESQSVPQEETIQACKVPAINEESQQFLSNLSQNPPPKPPSEAPRADMFMLHGWRDKWCKCENCMTKLSKHPWLFAEEATYEPQEEEQEEKTLLQLGAEALNTLPREKALDGLKAYEKMSSSVKDFLKPFADTGKTVEAADINNFFSEQQQKLKNGDNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGU1</accession>
    <name>I4YGU1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase CPK1</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Stress-activated protein kinase CPK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_59478</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956577.1">
        <property type="nucleotide sequence ID" value="XM_006956515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGU1"/>
    <dbReference type="FunCoup" id="I4YGU1">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGU1"/>
    <dbReference type="GeneID" id="18473377"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59478"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="I4YGU1"/>
    <dbReference type="OMA" id="IAMMRFF"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM23183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="42339" checksum="95F211C5B31EB4CB" modified="2012-09-05" version="1">MSSNQQNQQNQQRRIKFSVGTKYQVLDVIGEGAYGVVCSAIHRPSGHKVAIKKIEPLMHQMFLLRTLRELKLLKYFQEQNVSENIISVLDMIKPKDYPNFKEVYLIQELMETDLHRVIRTQDLSDDHAQYFVYQTCRALKAMHSADVIHRDLKPSNLLLNANCDLKVCDFGLARSTQTAEPGCETGFMTEYVATRWYRAPEIMLTFKQYTSAIDIWSVGCILAEMLSGRPLFPGRDYHHQLTLILDILGTPTLDEFYAISSRRSRDYIRALPFRKKRSFSQLFPDASPEAVDFLTRTLTFSPKSRMSVEECLSHPYLSAYHDPDDEPSAPPLDASFFEFDHRKDVISKEELKQLLFEEIMTFKPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH69</accession>
    <name>I4YH69_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956697.1">
        <property type="nucleotide sequence ID" value="XM_006956635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH69"/>
    <dbReference type="FunCoup" id="I4YH69">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH69"/>
    <dbReference type="GeneID" id="18474777"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62680"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040077_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH69"/>
    <dbReference type="OMA" id="VLPEHLC"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="339" mass="38409" checksum="6F34918E9E155E25" modified="2012-09-05" version="1">MVLRINEKEANPNPHINFTTALPSAKQSEARELLRSLAAQVRPVMKSEGLKVNSFEEYEFNQVFAGRNWNAGDVRMFISILELSNNIIKIVELVLRRPNGQFYPFPFLLNVLCHELAHIKHMNHSKAFHKYNEELRIKVTSLREKGYFGDGYWSSGTRLADNATVQGETALVAGDFMEYICGGAQSRPKSSIWRHKKRKKPLTRKGMIIGAGNRVDGASLQLDKSQDLNSTYKKRASSKNARQIRLEATEMRLSALTKAKQEEEEGSRSTTEDEPDYIESDVDRRHLMGDIKVEDTGSAWDAFLCQDIKPSDHKRSDPKSKAGPSKARNKGNKEVIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH70</accession>
    <name>I4YH70_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956698.1">
        <property type="nucleotide sequence ID" value="XM_006956636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH70"/>
    <dbReference type="FunCoup" id="I4YH70">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH70"/>
    <dbReference type="GeneID" id="18471301"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31438"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="InParanoid" id="I4YH70"/>
    <dbReference type="OMA" id="MDDKTFT"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="26129" checksum="39AA54D5D92EA68F" modified="2012-09-05" version="1">MGDYVDRGYYSVETVTLLVALKLRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDHIRSIDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHSNGLTLVARAHQLVMEGYNWSQDRNVVTLFSAPNYCYRCGNQAAIMEIDENLKYTFLQFDPAPRAGEPMVSRRVPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHK0</accession>
    <name>I4YHK0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_31512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956816.1">
        <property type="nucleotide sequence ID" value="XM_006956754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHK0"/>
    <dbReference type="FunCoup" id="I4YHK0">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHK0"/>
    <dbReference type="GeneID" id="18471317"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31512"/>
    <dbReference type="eggNOG" id="KOG1598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317883_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHK0"/>
    <dbReference type="OMA" id="REEANFY"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="370"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="750"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="806" mass="91472" checksum="1BC8335EDFE347F4" modified="2012-09-05" version="1">MPQQPCRDCGSLNIDHDSSSGSSYCANCGIVFEESNIVADVGFTESSSGQAHVTGTLVAHDATGTSRESRDKTIQEGKRRVRQLAAALRISEAVAESGERIYTLAVQNNFIRGRKAVYIVSACLYAACRLQKDSHMLIDFSDFLQINVFALGTTYLRLVERLDLKLPEMDPSIYIQRFASLLEFGQETQRVASDATRLCRRFDEDFISHGRRPAGICGAALLLAARMNNFRRSVEEIVQVVKIADVTVQKRLDEFSRSTAGDLTIEDFRDDQHWHNNRANEEALPPTFYKARRKEKIEEEAAAKPESELAQKLQRAKEKKRNLEASTRPKRKRNDPIHKQFEDYYETICGVSGVLEDFTPQKISKGIEKAREDRARYKQQKSRQDDDDYSGSEIFELESEDGDDGNTYSRTSIRKSDRLLRNSEEPSYVYPGEDEVNDEQAYEQGISNQPAKLRDISINHVVTTPINNDPETPSRDEEEEEERGERGEQEEEEEGEEEERKDVELEEELDIDHNEKDDEDNEEEVLDTKEDENGAEVINDENIDMEKAHNTPNQPDDGTVEEAGSPSAAPLSEQQPGEDDSNEKDENEKYDDKEGEEVVEEPGDPDVKSSAPNEDDEGITQEITQALGDPNIRSLANTLDNVDERRRIELERRNANVDELQGLDESELDDMILGEDEVRVKERIWMEFNKDYLEKIALHQATGQDQQKKPRRKKRKAKDQSAKPENAAEAASQVLKQRKISKKINYNALDGLFKKDTGTPEINSLAPGEVDDKDDDKEDAKEDEEEEGEDQTALEYGAEFSDNDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS0</accession>
    <name>I4YHS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_49940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956189.1">
        <property type="nucleotide sequence ID" value="XM_006956127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS0"/>
    <dbReference type="FunCoup" id="I4YHS0">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHS0"/>
    <dbReference type="GeneID" id="18472513"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49940"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025752_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHS0"/>
    <dbReference type="OMA" id="THRSAMM"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="266"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="635" mass="70358" checksum="34E6AFF8AB3472FA" modified="2012-09-05" version="1">MVKLRADSDDEMSDEKPPIRRSRRNSVKQTNSRATPPPKSDKVRKTNNNDKIPRKPGRPRKSETKKKHTQNQVSRRVGRPALAEKNRERSVTKGAVKLENSSTNSDNSSDEKDPISVKMEEDAESMTSGSSSTEKDSDEERRMSDYSGSDSEEDDDVEADKSDEEDVMEVDEPSSDEERPKRRSRSAKPPRTPNAKRYELHRRAAKAVKPLPAPAIESLNDTTDKDARSLSRALLHVGATPGYLPCREDEYLMIEGCIESLLEDGQGGCVYISGTPGTGKTATVHSVIRGLIERSNNMEITPFKYVEINGLRVSEPARAYPILWDGLKGDQMSLSPKAALNALENYYAKGSNDEACVLLMDELDQMVTNKQSEVYNFFNWPNMPRSKLIVIAVANTMDLPERVLRGKVKSRLGMERINFAPYDRMQLIEIVQSRLRYAVSLADGKDYTHLTDEDTRGIFDEDAVKIAAAKTASVQGDARRMLEVCRQTLERTVTLPVKTSHVQQTLKAMSLSPLSRLMSSLSLSAKIMLVSTMRCAIAAGMGTGECKWGDVSNLHSKLSAQIIPYNPPIALSKTDQYAILSALAATRIVLAHEPGASNTGLNKGSDAERMLILNIPEADVRRVLGEDARFQSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHV9</accession>
    <name>I4YHV9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956227.1">
        <property type="nucleotide sequence ID" value="XM_006956165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHV9"/>
    <dbReference type="GeneID" id="18472775"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56141"/>
    <dbReference type="HOGENOM" id="CLU_970447_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHV9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="287" mass="32523" checksum="3ABD9E002EB10734" modified="2012-09-05" version="1">MGVGNFARQPATPQTETNVEVNKTPQPAAQDDFEERLKRAAATIAPSRNDEPLTDHDRKKIEGLRRLVEKRRSVSHDKSVSSPASKTGTFRRAETVMSPTKEKTPKSTNNPENKTFRKEVIVIEDTESEDVDENHSQDEVEGEVEFDRENTKSIGANEKETIHDVGGSELEWVLERNRREEMSDDDYEPDEDSQDEDAQAKHKRGHAHSTNLAPRRSSNRRKYTSQSSSLPNGHQPSHNTPRKTRKSTLRSSPSPTDPPSASNTKYRFNNYEVKLVTQCALTESRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY8</accession>
    <name>I4YHY8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956254.1">
        <property type="nucleotide sequence ID" value="XM_006956192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY8"/>
    <dbReference type="FunCoup" id="I4YHY8">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHY8"/>
    <dbReference type="GeneID" id="18473261"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59272"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_1"/>
    <dbReference type="InParanoid" id="I4YHY8"/>
    <dbReference type="OMA" id="FGPGGCM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="103"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="258" mass="27911" checksum="DD400B355831C040" modified="2012-09-05" version="1">MISRIFRQTRSFSSTNALPSGHNKWSKIRHHKGAADKARSKVFAKMALDISAAVKLGGGATDPALNARLSNALAKARSLSVPKDNIEAAIKRGDAGAVDKGHSVTYEALLADVGLIIECQTANVTRCNHSVKTILAKHGGRMASCGYLFSRKGVINLELQDSASFDTLFEDSIDAGGEDIVQKDHNLVEIITDPSQLTRVAESLIEKGYTLSSYDLAYIPVSGERQEIDDEIRETLTNLIDTLEEDSDAVDVHTNSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI00</accession>
    <name>I4YI00_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_14803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956141.1">
        <property type="nucleotide sequence ID" value="XM_006956079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI00"/>
    <dbReference type="FunCoup" id="I4YI00">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI00"/>
    <dbReference type="GeneID" id="18470643"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14803"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="I4YI00"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="383"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="724" mass="82340" checksum="0BF69BC5929EC05C" modified="2012-09-05" version="1">MKTSPQFVDEVPHKPATDYSRWRLQVTDVGRHQWKYLSPEQSAASPQTIEDKFWLGLETSLPQLPEPRNPFDAARNGFKFYKQIQSVDGHWAGEYGGPMFLLPGLVISNYISGVKLAEEQRVEIIRYLFNRAHADDGGWGIHIESLSTVFGTALNYTALRLLGVEADHPIMTKARGTLHKFGGATGAPAWGKFWLACLGVYDWDGVNPVPPELWLLPDWLPIHPTRWWIHCRQIYLPMSYLYGKRFTGPSTKLTEELKEELYVEPYASINWPAQRNNVNKIDLFQPHSAIMDALNAILYYGYESCAIPPLRQAALRKAYEHIVHEDENTSYQGLAPINKAFNQLCRLDAEGADSEAVKKHVEKSDDFLWLGPDGLRETGTNGSQLWDAAFIAQALVETGLGEEEENKGATEKLLDWLDKCQIRQDPPYPAYRQPTKGAWPFSTAEQGYTVSDCTAEGIKSVIFLQEHLKHTKQLVSYERLQESVDLLLGMQNADGGFASYELTRGSKHLELLNPAEVFGKIMVEYSYPECTTSVVTALSLFKRYQPNYRREEIEKTTAAAIKYIHAAQRQDGSWYGSWAICFTYAAMFALESLSSVGEHYDNSEKVKKACEFLLSKQKEDGGWGESYLSCELEEYTHHENSQVVQTSWVILALLHAKYPHKEPIKRAVRLIMSRQNKDGSWTQEAIEGIFNKNCAISYPNYKFSFTIWALGKAYREFGDIDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI39</accession>
    <name>I4YI39_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956301.1">
        <property type="nucleotide sequence ID" value="XM_006956239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI39"/>
    <dbReference type="STRING" id="671144.I4YI39"/>
    <dbReference type="GeneID" id="18473279"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59301"/>
    <dbReference type="HOGENOM" id="CLU_654184_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI39"/>
    <dbReference type="OMA" id="LVHEPPW"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="411" mass="45927" checksum="5FB4AB451DF0D92D" modified="2012-09-05" version="1">MTLKVKLNTDSLKPGDHLDASKKRKSTQEDDESTLIGGDSELIRGLLEKINPSLLDLNVDADSPKKRNHSSLGGYINDGEGSLFLVYDTLRNGPIDTDKELAISVINSLVAQRKAKLPPAESIQLPETTVDSQLEKQQLRKARYALQQSWPGVDYFTQASDVDPAVASELTLGTATVVPIPENPSIKVPNAPKLKDISKPSPHTTINSSTYGTFRDKDVSHLYYGSNYSFGPCYDSTNATIPYSTSLNIATTSQMKTLEEPTMVQFHGEPVSAHENKEISKDELDNVNIEHLPEAYESLNRGYLETQAKLKRNAFLLAKLKSLEAQRLRSDIPNEPSEEEQEVAKKLTQSFTDMLVHEPPSQFYEVRQLHRLHPKPEMAHYYGTLHPEYTDMLVDNVSVRPTPAALRKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT4</accession>
    <name>I4YIT4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_26636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955720.1">
        <property type="nucleotide sequence ID" value="XM_006955658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT4"/>
    <dbReference type="STRING" id="671144.I4YIT4"/>
    <dbReference type="GeneID" id="18470947"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26636"/>
    <dbReference type="eggNOG" id="ENOG502S60R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008678_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIT4"/>
    <dbReference type="OMA" id="ANTRMKR"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50265" checksum="14291569B62A265B" modified="2012-09-05" version="1">MSAENSTASNQDVSLTMEHTRPRQFKCSWRTLLQFPRRLLAPAAIPSAPKFKVRSCTATPLDSVTLESILNDSYLPPLTLVDFQDYLVFRENSVENLFYLRWLTHYTSLHNRLVIEKTQEESSKVINEMSQQYQRCLSTFILPGSAYELNIASKLIQEMLAIAPQQYVTLDDLNGTQSDRHAVLPPSPDAAAIVATKHHVVEMLRNSARKFATKAPANGGRKRGWFALFVGLLFILLGLLIVLVARLYQKGSGGRHTAGAAIPFFWFGVATFVMGLHGICIVVFMFGDARQLHPFEMDMPKDDSPVGTPHRTGSDTLGVGADVYGLTVTKTSSRDTSSDEAGTSHTSHTQLGNLEKGDISLVGGRMQRKFQEVPPQTSSRPLIDTPFVPDIPGHLKRFGTVTRQSTPRSAGVRGIFEPLTSVDEPIVSRVQLQVFYLAAVWGTILAVIGGVLAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ42</accession>
    <name>I4YJ42_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955819.1">
        <property type="nucleotide sequence ID" value="XM_006955757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ42"/>
    <dbReference type="GeneID" id="18474685"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61813"/>
    <dbReference type="HOGENOM" id="CLU_2374375_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ42"/>
    <dbReference type="OMA" id="GMPTKDN"/>
    <dbReference type="OrthoDB" id="10337875at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="95" mass="10268" checksum="00E55A6316E3B9DA" modified="2012-09-05" version="1">MPQEFKKAYQTVDPAGHGIPTEGLNDRAMGQRAAGIAGTTSSTTDQPGPLDDRTHEDKYADAQATAQVNKGGNNVEPTPQQQRDIEAMNERIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ73</accession>
    <name>I4YJ73_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955848.1">
        <property type="nucleotide sequence ID" value="XM_006955786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ73"/>
    <dbReference type="GeneID" id="18473146"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59053"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_4_1_1"/>
    <dbReference type="InParanoid" id="I4YJ73"/>
    <dbReference type="OMA" id="HTPPYGI"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="26070" checksum="A9C0348FC84C2984" modified="2012-09-05" version="1" fragment="single">MNSVNNKYAVYFKYDINNPPEKLHNSTRFILISDTHNRTFHIPDGDILIHAGDLTFLHKVNYDITARWLIEECDIKYKVFIAGNHDKLLLRDGKPYSDGSWNVDFDTDYDPQAIDSLCGKQGVSNGLFYLQNNTKKCTVGDRTWNIFGSPLYSSRRPTEHTAKETLRIVNNFPPMDVLITHGPPRDILDKTKTNLNVGCVELTEALHRLKPILHVYGHIHESRGYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA2</accession>
    <name>I4YJA2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955874.1">
        <property type="nucleotide sequence ID" value="XM_006955812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA2"/>
    <dbReference type="FunCoup" id="I4YJA2">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJA2"/>
    <dbReference type="GeneID" id="18474690"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61874"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031771_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJA2"/>
    <dbReference type="OMA" id="HQVIRYS"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="431" mass="48307" checksum="C836297555F51528" modified="2012-09-05" version="1">MSVYDSDDSEFSDYESNVHLGLPDGGPISDLDDRTIEISRIGGQPSFPRLRNLPSTSSNLCKVCNNNMELLLQIFAPYPDSVNDRVLFFFACSRASCQKKDGSVRAFRCLSRNEKWARKLAKLKQRDQEKKKKQAEEDKKAKEQATTNPFTAGKSNPFSQTTGAFGADDSDSESEEEQPRFKKIIESDSEESSEDEDEGLEAELAKLEISDGGVAPTKQYWPEQPSYATQYIATTPEVIPKPSKDSKVKIEDVKQTLQGAGGNSELEEFEKSMGNGMDEAFEHFIKHVNYEPQQCIRYELGGTPLAYTNKDGVYKKLFGGANEASVANYDTAKLPRCETCGSKRVFECQITPNIINLCNNTTQNNNLSEEERKKELEEALAGKSKGSTKADMEWGTIMLFVCENDCCLESGSQSKEAREQWIEELAYVQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB7</accession>
    <name>I4YJB7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955888.1">
        <property type="nucleotide sequence ID" value="XM_006955826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB7"/>
    <dbReference type="FunCoup" id="I4YJB7">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJB7"/>
    <dbReference type="GeneID" id="18475180"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66924"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="InParanoid" id="I4YJB7"/>
    <dbReference type="OMA" id="AFHSMMQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="98"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="46497" checksum="3582858F391AF7E2" modified="2012-09-05" version="1">MVDAIPEAVLEVPRTLKESFKAWWSYTDDDGLKSQERMFAKLPFDKVNKEDLPSIDTPKRVAYTSLVDINHPSFDNPVKINTLEIGSYPKPNPAEEIPIVCSHGYAAATFFFLNNLHALGNIPKTRFYGMDVLGMGLSERVKFPHINTSQPVEKRVGQAEDFFTDALEAWRKAQGINKMILIGHSLGGYISTVYALKYPEHVKKLILVSPIGFPKNPESVRAESLNKDLAQAESQSRTHEFSDMPETRTRKALKSVIRYLWEDRNFSPFDILRKSFFFGPMLVSSYSLRRFSTLSDDLQRDLYHYIYSISVRKASSEYSITHLLSFGAYARLPLIDRIEKLDKRIPVTFMHGSVDWVDGGEAAFEKMKNLGFDVKYEETPRSGHHLYLDNPEDFNRFIVKDIESCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJD3</accession>
    <name>I4YJD3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955902.1">
        <property type="nucleotide sequence ID" value="XM_006955840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJD3"/>
    <dbReference type="GeneID" id="18474694"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61904"/>
    <dbReference type="eggNOG" id="ENOG502SCA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4YJD3"/>
    <dbReference type="OMA" id="CCDQNNY"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013985520" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="107" mass="11066" checksum="EE46D807AB8BCE40" modified="2012-09-05" version="1">MIAQTVFAAALVASVSAGWESKSETGSCNTGKISCCNLDKKAEESTGKNDALISTGDILSQVGVQCDQVPLLIGVAIEDECKNTPVCCEDLKDDGLVGIDCTPLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJF6</accession>
    <name>I4YJF6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
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        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EIM24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006955862.1"/>
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    <dbReference type="STRING" id="671144.I4YJF6"/>
    <dbReference type="GeneID" id="18473167"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59088"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_2_1"/>
    <dbReference type="InParanoid" id="I4YJF6"/>
    <dbReference type="OMA" id="EYQMNTQ"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="255" mass="28520" checksum="29FB8B59A197BF3E" modified="2012-09-05" version="1">MVFPKSLIFAAATATTLAKPFDKRQNLGLVENCYHDFAITFDDGSVGAEYDLVDLFNENESKATMFLNGFNYNCIYEEDSVERIRNTYNSGMLIGSHTWSHRNLGELSEAEIDEQVELVNDAIWKIIGVRPKFLRPPYGSAPEWAVNYIQEKHGMVVVNWSEDSLDSQGASADESIGIYDGFTDVNEPHLTLNHETYETTPYTVMPSVVPSLKERGFNLITVAECLDLDAYLEVGEPQARDETWTCEGKPAPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJH2</accession>
    <name>I4YJH2_WALMC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955940.1">
        <property type="nucleotide sequence ID" value="XM_006955878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJH2"/>
    <dbReference type="GeneID" id="18475192"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66971"/>
    <dbReference type="eggNOG" id="ENOG502S8P6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329880_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJH2"/>
    <dbReference type="OMA" id="TARTHSW"/>
    <dbReference type="OrthoDB" id="2526154at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="842"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="870" mass="96090" checksum="221D581A0D81BD64" modified="2012-09-05" version="1">MNGLFDAPKKLKGLSIAQVVGEDNDEEATTQKPDWIKNVKGTRLDPQRLALVASVFGYKLYQAPRNQLKSGYLLSVIPPKSLSIKRNNHNQLNRGILLPLELSISAQRASIAREFNLPSSGGLIIYLINEVQDINNDKELIDEPGPLINEKSWKLLWKSFFHSPNFEERHPDKLPNDPESDQPNSTPPSLKVPTQHQSIAGKIEFDIDTSSKSGHWYKNWPSQTPQTSYNENEQRPFRLRSNTQEIVYSHDNSQVPTPAALSAAAKTKLDTTQQDSPRSTSSLPYRAFELETIQSLLQPGSKVQSGRNSPTSQSRAGSPSGARNRGSVHVMQDTLDELEKALADLSPRPIEQNQDFGQRRDAVHKAARTLSKIGNREGFHLPRKDDGTLKAFDELTEEDENNFEQHGTAKNKSDLENDLVGSVDGYREDDEPIDVPKSPSRSTESRSNSLSNSSESNQNERLTETPATETDLSRYTPPPQTQTQTKPHLSITTNQNPQFNISPSSPTPIPKTAPAEASQMHAPSPPRSAIPKSPSIASVEERRSITKTPFSFGSRRKESIQIDRKNSTESKRSLSIKDSGSSLDGLGIRGLKFWSSKSNQNNNQQHRQREPSITMPVGVVKTASGGPGKLANTGHSGNSPNGLPSRAESMRSVSPTFSNNDNGNSSTTSMIEHFPDSRYPKDVELGDGRPEMIPLPPSVRQNSVESIHTHRTQSSTSTAGSLKGRGFMPRKQSLDYSTLPTALPSTGSHSTPLPSTATFALPEAIPENLEDARRGSADSEQRKIDEIISKEREKDFEAKVEAFEQEQLASQARAKALTQQEETRKAIKQEEQDPEPKKKGEPGSRFSASPPPSPPRKLPAVPVFSRKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJI7</accession>
    <name>I4YJI7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside phosphatase GDA1/CD39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_66984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
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                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006955893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJI7"/>
    <dbReference type="FunCoup" id="I4YJI7">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJI7"/>
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    <dbReference type="KEGG" id="wse:WALSEDRAFT_66984"/>
    <dbReference type="eggNOG" id="KOG1386">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_3_1_1"/>
    <dbReference type="InParanoid" id="I4YJI7"/>
    <dbReference type="OMA" id="TAYEVCF"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="83872" checksum="A624091CD9E98289" modified="2012-09-05" version="1">MAPAISTRNYAIIIDAGSSGSRSQIYSWDNSIATEAHAPELPYVELGLGRAVAGDKPSGWKVEPGISTLEPSVNELEVYLRQLLEPALNIIPPSARQNTPVYVLATAGMRLLNLDRQKAIVNAADAALERIVGYDTDTELKMRVITGEEEGFFGWLAVNYLMDGFVSKRKPGSQHTWGFLDMGGASTQIAFEPKRGWGDGIPREIDDGLIDFKLRMTDGSYRDYTVFVATWLGYGTNKARDRHVSHLLQLAQSEANYKSYEKPAEDVSQDDDDDGLQIPDNSSSRLTIDDPCLPLNLDVVDPHTDNFIHGTGSFPGCLRALEPLLEREAFCAHPPCLFGGQRVPPIDFQLDRFVGVSEYWFSSEHVFGLGGAWDLVRFERAAEEYCSRDWNVLTEEWEAGHVSGVSGKWGDQIDLPRLRMQCFKASWIVQVLHSGIGIPRIVDPGGNITNSEDPSVKGKEMAEQKGLARPDDEPVFQSVNSVDSVPISWTLGSVLLTASGSQSPFVTYSPKDLPKYTKNSGKIFNFKMSSMLDDRLSSYAQWILIALFVVLAVYIVYRIRRGRNSRRRHEYSSLPAHLEEGTEAISLNDLNSPSARSRGQNALQNVNGWVRRLRSYFRGGARSRTPKLRHSGGPPGPVSQPLQQTASSPAIMTVKSAPTSPKRSSPRLSTASRMSNDDGVTGLGLFRNTLALNRSSSNINTPPRDEQPKHLQAEPPTGTPRASLSSRNNSSVNLTTLVSRTTSSAKLNHMTGFTKEYEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJR2</accession>
    <name>I4YJR2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956023.1">
        <property type="nucleotide sequence ID" value="XM_006955961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJR2"/>
    <dbReference type="FunCoup" id="I4YJR2">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJR2"/>
    <dbReference type="GeneID" id="18473194"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59141"/>
    <dbReference type="eggNOG" id="KOG0572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJR2"/>
    <dbReference type="OMA" id="IRHFGVK"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="538" mass="58962" checksum="B35ADD76ED584A4C" modified="2012-09-05" version="1">MCGIIGLVLQDTNVAVSPELAEGLSLLQHRGQDACGIITCGPRGRLHQVKSNGMVRDVFDNQAISTLRGCMGIGHVRYPTAGSSAQSEAQPFYVNSPYGITFAHNGNLINTNELRHFLDQDAHRHINTDSDTEVLLNIFADNLQQTGKFRINEEDIFAAVKDLTRQCKGAYACVAMIAGFGIVAFRDPNGIRPLGYGVRAAGEPVNGIISPQGDKQKTGLDYVFSSESVVSDALGFSDWVDVKPGECMIVTRHSVARRQVAEPAVFAPDIFEYVYFARPDSVIDGISVYRSRMSMGDTLADEVRKQLHGSNTVDVVIPVPDTSRVAALQLAQNLHIPYREGFVKNRYVGRTFIMPGQQQRRKNVRRKLNAMALEFSGKNVLLVDDSIVRGTTSKEIIQMARDAGAKNVFMASCAPAIRYSNVYGIDMPNRKELVAHGRTEQQVADYIGADKVVFQTLEGLIQSCSSLNEDIKNFDCSVFTGQYITGGVDVAYLEHLENLRADNVKHKVESVETSFTSLGCSGPMNGADDNIGLANQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJT3</accession>
    <name>I4YJT3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_30927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956043.1">
        <property type="nucleotide sequence ID" value="XM_006955981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJT3"/>
    <dbReference type="FunCoup" id="I4YJT3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJT3"/>
    <dbReference type="GeneID" id="18471212"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30927"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="InParanoid" id="I4YJT3"/>
    <dbReference type="OMA" id="GEKWYDW"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697868" description="Maltase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="97"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="303"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="732"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="948" mass="107062" checksum="57BF552F77775C77" modified="2012-09-05" version="1">MKTTPVVASLLTSALALSPLSANDYGNRVLDCPGYAVDEAQTEQTANGLKAHLQLAGDACNAFGEDVQNLVLEATYETKERLHIKIYDEEEKHFQVPEEIFPRPQFDVDESLRDNSDLEFQYSDAPFAFWISRRSNGDVLFDTRLSEIPAYGEPYDANDTSASVSVMPNHNLIFEPQYIQLSSALPQGANIYGLGEAVTPNYRRNSSYTRQTNWNNDEGTPTDTNIYGTHPFYIENRIKDGKSYNHGVFMLTTNGLETWLRDGVWQARSTGGIIDLYVLSGGSDGENKPTDVIRDYGKLVGRPYLPPYWSLGFHLTRWGYNNDTHFESILNAMYDAGIPQESAFFDIDYLTDYRDFTVDQNSFSRLPEIVNKLHARGQKFVPIVDNAIPITRNESDVYDFYTEGHEQDVFIKNQNGTEYIGQVWPGYTVFPDPYAENVGKWWTESFQKFFQEIPFDSIWLDMTEPASFASGSLNGLGPLDRYEPAAVSMWPEGYDNITSGNSGNITVDGKLTYMQKPEEQKPSRRDMLSRRMGTLETVDNDLEKLTFPPYQIHNGAPNEFNELGHKTVAANATHANGYYEYDVHNANGHMIAKHTRDALDTIYGGNRSMIIARSNFAGSGRFTQHWLGDNYSTWQSMADSIKGLFQFSAFQMPFVGADACGFSGNTDEELCTRWMMLASLTPFFRNHNVYGSIPQEPYRWTSTEEATKKAINTRYQLLPYFYSNLYQQSIDGTPFIRPLFYEFPTNDELLDWDSQFLVGDHILVTPVLSPNATVVEGFFPGDETYYDWKTHAKLEVNNEHEAVGLETPLTDINVHIRGGAVLLLHSEPGMTVTETTESPFNALVTMNKNQEAGQSYWFDDGHSAFNESNTYIWFDVNSSGIKSRVDANSYDIGQPLNNVDIIGWSGSAPSSVKNGDQDVEFEFNADTETLSLRGLNHKLNENLDIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJV4</accession>
    <name>I4YJV4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_56045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956062.1">
        <property type="nucleotide sequence ID" value="XM_006956000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJV4"/>
    <dbReference type="FunCoup" id="I4YJV4">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="GeneID" id="18472764"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56045"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="InParanoid" id="I4YJV4"/>
    <dbReference type="OMA" id="TIIHGPP"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="152"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="170"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="675" mass="76529" checksum="D1333E34DE6159C2" modified="2012-09-05" version="1">MDEVWERYRRLLKNELEESRKEAISKISIKLTSFSVSFNSKLLLSLTSTEKHSFRNGDLAAIVNKKNTQLLRGSVYSADDKRILISIEKNEIDLPSPIYLTQLRDESTYTKLLEMIDKYEYLERSDDLSLLMKTIFGLRKPTFSQRAPSEYFDSTLNQSQRHAVNLALKADHLALIHGPPGTGKSYTLIEIIRQFISQDKRILVCGSSNLAIDNILERLSVYNIPATRIGNPARILSNLQTQTLEYQTLQSEENVIMKGVKLELEDLMKELKEGNITGTLERKKAMNEVKELRKEHSKRSMAVLNRLMKRAKIVLCTLHGAGGKQLENQKKFDVCIIDESTQALEPSCLIPILKAKKLILAGDPLQLPPTVLARPAQKVEGKTKEEKKTTIWKEQDIKEVEEITDKLAELKISEEGNATDREFKQASTRATLKPLESLEASLFERLIDIHGNSIRCLLSVQYRMHNMIMKFPSETMYNSELTACEAVSKRTLMELPNVVNSNTNKDSVQLSSPLVFIDTDGHGCKESIDFKRLKKGALQRGSKYNEKEIEIIKRKVQDLVHVGVRDSQIAIITPYQAQVVRLGNAIKSQFPGCEIGSIDGVQGREQEVVILSLVRSNYTGQVGFLKEGRRLNVAMTRARRQLIVVGDSATIKRGNSYLKKWMHFLKSNADLQIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK11</accession>
    <name>I4YK11_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_34979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956115.1">
        <property type="nucleotide sequence ID" value="XM_006956053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK11"/>
    <dbReference type="FunCoup" id="I4YK11">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK11"/>
    <dbReference type="GeneID" id="18471897"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34979"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024991_0_0_1"/>
    <dbReference type="InParanoid" id="I4YK11"/>
    <dbReference type="OMA" id="YGGHEAW"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="11">
        <location>
            <begin position="253"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="12">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM24303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="518" mass="58308" checksum="85D06D248241EFFF" modified="2012-09-05" version="1">MNESDPATRRSQIRNKSNPLARPSTSARPKKVSLNSQPIKQKTSTSDRSVIDALTRFLNTRYDPNLNYLNLENMGQDEILKSANFIPPGYNKQKSLAGPSLFKLISELFPEVKTISLASNHLRNMNAFKALPEFIPNLVNLSLSDNDIRHVEDLYALCTSKKLRNLKELILSNNPISRFGDTWRARVVRKFPSLELLDMKPVERSVKFDFGDGVKIDPKKERTPSEATEALPEVFPIGIVGSFGRDNPEVGPLVGEFLTRFFSLFDGDRNALLAAYTENATFSLCVNTNTPPRARRQNLYDGKPKIMWKPYVDNKPIATSRNCSKIYRNDMRNEKLSTGNKMIIEAFKILPKTTHNISDVDKFVFDCWTMPGVIPSTPVIFCSVHGEFVEGTTKGFRSFDRTFILAPSTVSKFAADSGWPCAIISDNLNLRSLSKSDAWQPGPIETMESSKGILLKLPKDPPSSISKDQHNIIIELAKKTKLNYEFSIQCLQSNNWSLDMALQNFEAVKTSIPQEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK14</accession>
    <name>I4YK14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_30985</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956118.1">
        <property type="nucleotide sequence ID" value="XM_006956056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK14"/>
    <dbReference type="FunCoup" id="I4YK14">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK14"/>
    <dbReference type="GeneID" id="18471228"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30985"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="I4YK14"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="75"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="262"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM24306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="427" mass="48425" checksum="09E8C4F393058748" modified="2012-09-05" version="1">MADNEDLIDYEEEEVAPQQQQQQQPTEQADAKDKKGSYVGIHSTGFRDFLLKPELLRAISDLGFEHPSEVQQECIPQAILGMDVVCQAKSGMGKTAVFVLASLQQVEPVDGEVSVIVLCHTRELAYQIKNEYGRFSKYVPNIRTSVFFGGVPITTDQETLKNKEKCPHVIVGTPGRINALVRDGSLKGSAIKHFVLDECDKMLEQLDMRRDVQEIFKVTPHHKQVMMFSATLSKEVRPVCKKFMQSPLEIYVDDETKLTLHGLQQHYVKLSESAKNRKLNDLLDSLDFNQVVIFVKSTLRANELDKLLRECNFPSICIHSRMSQEERIARYTKFKQFETRILVATDIFGRGIDVERVNIVINYDTPTDADSYLHRVGRAGRFGTKGLAITFVSQDEDDEVLKAIQSRFEVAIPELPETLEASTYMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK20</accession>
    <name>I4YK20_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956123.1">
        <property type="nucleotide sequence ID" value="XM_006956061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK20"/>
    <dbReference type="STRING" id="671144.I4YK20"/>
    <dbReference type="GeneID" id="18473223"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59201"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514840_0_0_1"/>
    <dbReference type="InParanoid" id="I4YK20"/>
    <dbReference type="OMA" id="EWTFESG"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56390" checksum="7F0122AE5B2A21B0" modified="2012-09-05" version="1">MITRRGILVLTIILSTFSLLLLLNKSSQLSSSDFSHLRSTFSHRPAIYKYPTQLPDLPDQLSSRLADILDQPALNHTEAYDTNSAICLPKTHELLGDTQQLKEELENWENVTPEEILNIRSQIINHLEVLGDDAVYDFEKAGLARNETTRGLVITAGNKDTHQRAITSLKLLRNMNFTWPAEIFQYRDERLSTDINATYASLNATVRYIDGVTKDVRSDDEHNYQIKAHAIRDSSFREVLYMDSDNIPIRNPDVLFEDPMYSDSSSPRVTFWPDFQKDHPANPIWRILGIPCKSDEWRIDSGQIMFDKAGNDGMNLAALHIAAFMADNHKYWFKLAGGDKDTFRYAFHFLRIPYVHAPNWLAAGGAPTPISRDKNIRFCGHTKIQFDLNTFEPRPVFAHAQLLKGANSDTTTPSQVFASVKKSSKALANKPSSGSAIEIYDGPRGKCFNLLGGKKDSYEIWLEDLMRFGTDPAYHGWRTAKWERQWRQQGGFVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y517</accession>
    <name>I4Y517_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70900</name>
        <name evidence="2" type="ORF">WALSEDRAFT_70902</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="1">CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960892.1">
        <property type="nucleotide sequence ID" value="XM_006960830.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960897.1">
        <property type="nucleotide sequence ID" value="XM_006960835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y517"/>
    <dbReference type="GeneID" id="18475815"/>
    <dbReference type="GeneID" id="18475816"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70900"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70902"/>
    <dbReference type="eggNOG" id="ENOG502S6CP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428749_0_0_1"/>
    <dbReference type="OMA" id="WVSCYTL"/>
    <dbReference type="OrthoDB" id="2387577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="91" mass="10644" checksum="51EE5774D5CEDF48" modified="2012-09-05" version="1">MSTTRCENYSFPWIFKDYQKRTGLDKIIKLYQSLNLSSEQFDFKLSWNLSPLQSSRFSLEYLLLPPRSALETVPLNITVKASIQSPRLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y564</accession>
    <name>I4Y564_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF92-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_12096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960833.1">
        <property type="nucleotide sequence ID" value="XM_006960771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y564"/>
    <dbReference type="STRING" id="671144.I4Y564"/>
    <dbReference type="GeneID" id="18470599"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_12096"/>
    <dbReference type="eggNOG" id="KOG4491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y564"/>
    <dbReference type="OMA" id="MSSFACC"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32049" checksum="C1D15356D849F82B" modified="2012-09-05" version="1" fragment="single">AALLATYLAYSGLKKRSLSLSGAITAFIVGYAGLSSTICSFGAMLIVFYLAGSKATKVKHYIKYQLEDGHDSEKPGGVRNAGQVLANSYTGVVCAIVFRVQHIITTPSSITNTPQCILNGSYYISSQTLLLFTIGHFACCCADTLASELGILSGTYPRLVTNPWKIVPPGTNGGVSAYGTVVSAFGGFLIGLTAVISLAIEDSSCFGLNFSFGQALLSSKSFKLIILSILSGLFGSLLDSLMGATLQRTLLHKERGKILTDGSDPNFERMYNEAQKSKSKETPEVKLVSGYNILTNTQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y572</accession>
    <name>I4Y572_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_49498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960841.1">
        <property type="nucleotide sequence ID" value="XM_006960779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y572"/>
    <dbReference type="STRING" id="671144.I4Y572"/>
    <dbReference type="GeneID" id="18472498"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49498"/>
    <dbReference type="HOGENOM" id="CLU_145518_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y572"/>
    <dbReference type="OMA" id="MFRNIFP"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7614" checksum="DCF108AAED5A0913" modified="2012-09-05" version="1" fragment="single">QQRNSKKPKYNDPWARREAWRSNPLFGIGKFHKKLLPGFGTAVVAFTAYVLAEKVLEAPQPEKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G1</accession>
    <name>I4Y5G1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960775.1">
        <property type="nucleotide sequence ID" value="XM_006960713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G1"/>
    <dbReference type="FunCoup" id="I4Y5G1">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="GeneID" id="18474630"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61598"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y5G1"/>
    <dbReference type="OMA" id="DWTQITW"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="866" mass="97614" checksum="FB2D21A2EE59600B" modified="2012-09-05" version="1">MSTRRRPFTARSSSSLNSNIPRSIRSSINEQGGLPEDVYADSYTDDDDESSDADVFAFGPPSTANGNRGQFPSSEASSINQPPLSNFDEKYLSPHDDILRPPSSEPIYAADRVKRWSNIDSDDLYQHSPTHQFPPTQTLDKLELEYEEDSPYPEVRASVSNTDDPDIPTLTLRVWLIGGIFCAIAAAVNTVFNFRLPAPTITPIVIQLITYPAGKFLAYILPMDLYTMPRWLGGKSFTLNPGPFNIKEHTLITIMANVSVSPAYAMNVTVVTEMFYGHKLGAGFDILLFVSSQCIGFGLAGFCRRFVVWPASLLWPQCLVVCTLLNTLHAEDDENDGSISRFKFFIIAGVSAAIWYFVPGFLFKALSWFSWICWIWPRSPTVNQLFGVFTGLGMGGMTFDWSQVTYIGSPLVMPWWAECNVAIGFFALYWLVVPILYYTNAKFFNYLPISDSSPYDRYGNAYNISRILSEDNEFNATAYEDYSPLYLSATYSMVYLLGYAVATAILVHTILYHGKSIWYGMRNFKTEEDDIHAKLMRRYPDVPHWWYLSYMIVFLALSIAAVTGFDAQIPVWGIFVALLIPLVYILPASFIFAMTGQEIPINLVSEVIPGYLFPGKPIANMIFKCYSIQTMSEGLSFIQDAKLGHYIKIPPRATFTVQVTATIISALIQVGIRDWMFNSISDMCSVRQSANFTCPQNRVYYTSSVLWGIIGPDRIYGRHGIYHYQVYALIAGAILPIPVYFYVKRKPRSWLRNLNWPVLLTGPTYIPPATGINYSSWIGIGFIFQYLVRRTHFAWWSKYNFILSAALDSGTTLGIILVFLILQLPKDGGINIDWWGNTVFTRTADYFGMPYRSAPSTGFGEPVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5P5</accession>
    <name>I4Y5P5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p21-ras protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_41564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960680.1">
        <property type="nucleotide sequence ID" value="XM_006960618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5P5"/>
    <dbReference type="STRING" id="671144.I4Y5P5"/>
    <dbReference type="GeneID" id="18472217"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41564"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="I4Y5P5"/>
    <dbReference type="OMA" id="MPLREFK"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="192" mass="21997" checksum="544830B9825DE42B" modified="2012-09-05" version="1">MRSIRICVLGAGAVGKSSITVRFVHGSFYENYDPTIEDSFTKLAEIDGKTHRLQITDTAGVEQMMTLRESVIRESHAFLLVFALDNPSTFNDLLPIVEDIKRIKDTDGIRRIPVLLCGNKVDLGFERVFPSNFQPSGVFKGVKYLETSAKLKIGIEEAFLDLAKIYMDQRRVRRERHKQLHRHDKRDKCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R4</accession>
    <name>I4Y5R4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_34171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960698.1">
        <property type="nucleotide sequence ID" value="XM_006960636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R4"/>
    <dbReference type="STRING" id="671144.I4Y5R4"/>
    <dbReference type="GeneID" id="18471830"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34171"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2016983_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5R4"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="123" mass="13753" checksum="57AA9CDDD367A423" modified="2012-09-05" version="1">MCHNNDTGLNIQHHLTARDRKNKKLVKKLAKSQDAFITSEALIKQIPRLLGPGLSKAGKFPTPISHSDDIEQKINDVKSTIKFQLKKVLCMGVAVGKIDMAEDGNRRQRCPRCPRCQLPCLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5S8</accession>
    <name>I4Y5S8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960596.1">
        <property type="nucleotide sequence ID" value="XM_006960534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5S8"/>
    <dbReference type="FunCoup" id="I4Y5S8">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="GeneID" id="18471814"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34098"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y5S8"/>
    <dbReference type="OMA" id="FEVMECD"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="531" mass="58311" checksum="B0D54C435813566D" modified="2012-09-05" version="1">MKTSILIAAVASIASSSPLNQRATAVKAGSATSDQIPWPTDDGLSNDVYKYEQGHRGPTPTGIQPAAIQTAPAGYYPYVKEPNAPVIKPKARDAETVEEFDVTGKWGVLTPYRSSPVVLEGSSPLAPQGCSIDAINVVHRHGARYPTTDANPAVFAANLTEGVSNSESPVEFNGELEFLADWTYGLGGDILTPIGRTEESDSGSSFRTKYGYLLNKFTKHKPIFRTTTQDRMYNSAIEFISGFFGVSDWQDNAHLVQIIEEKKGGFNNTLNPMQTCKEKEVDIGDDLKKEWYNIYLQDALARINEQAVGYEFTIDDIYAMQDTCAYETVALGYSSFCSLFTKSEWEAYEYASDLTNYGNDSFGNPLAKARGLGWVQELLYRLSGDKSALEKPSTVNTTLDYDERFLPLDQAINIDFSHDVVIANILTALNLTQFATPLKSDAIAPYSKDNLRWVTANNVPFGSNVVIQSLTCSDEAEKAGKFNRIVINDAVHPLTGISGCEQEDKNGFCDSGAFINGLRQLVEDIDYDSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5T6</accession>
    <name>I4Y5T6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960604.1">
        <property type="nucleotide sequence ID" value="XM_006960542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5T6"/>
    <dbReference type="STRING" id="671144.I4Y5T6"/>
    <dbReference type="GeneID" id="18473066"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58789"/>
    <dbReference type="eggNOG" id="ENOG502QVV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015536_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5T6"/>
    <dbReference type="OMA" id="SIWHPLW"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="466" mass="51906" checksum="B19C077C6DFE595D" modified="2012-09-05" version="1">MLTRSARSRYKRLIGALYRQYTVDSSKKTHIIHSLLRNPVIFEPIRKPRSPIVLCHGLYGFDVWTPPGIPKLQLHYWADLMDILRNKIGAEVIVTGVPGTGSVKERADAMHNQLQNTVKGRDINFLAHSMGGLDCRHLLTHINPTDYKPRSLTTISTPHRGSPFMDWCAANIGIGAQAIQDTADASSQPLSVPSMPLSLKSPLLQAQPTTSTTNITNDPNSDSKSSLSSLPQISLPIAFTSSLSSYLLALLDSPAYANLTTAFTNGIFNPRTPDVEDVKYYSIAARHPGLGWWHPLFLPQLVLEASAKASMREAEGKIGDDYEGNDGLVSVSSAKWGEFLGVIDGVDHWWMRGSRGFPKDNKGSVTDATTNTKQPINHKDLYNTPESSWQDVNKQIESNWRGKEEQNVDSQQSSVSAIARWFSDRIPTSQSKANEDKEKSIEKYENHMDREKFYIALCHKLYQDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5V9</accession>
    <name>I4Y5V9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_34123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960627.1">
        <property type="nucleotide sequence ID" value="XM_006960565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5V9"/>
    <dbReference type="FunCoup" id="I4Y5V9">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5V9"/>
    <dbReference type="GeneID" id="18471816"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34123"/>
    <dbReference type="eggNOG" id="KOG0448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5V9"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="164"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="815" mass="90933" checksum="8A41F328510D2544" modified="2012-09-05" version="1">MQSTIYKDVDKAVSNDSTPHTQPEVDSRLGWGEEASRVYESTKERLLSTIGSTKSLLSDIQNFNSSAWTMHYPGIDCEQPQISSNSLHRTLSADGTTGLSTNDQQIVANPPEMQVLRLDLKLGASSAHPSALVNSLEKSSIATLLDSRLTKSSQHLEALSTRIKDTSSKVLVTGDLNSGKSTFVNAILRRNVMPSNQLPTTTLFCEVHPVEEHPEKIEQVHLIKSVRDAYSPHDESTFKPYALEDLEILCEENETNPNPPLLKVYLNDPRSANNSLLSNGTVSISLIDAPGLNLDTLSTTALFARQEEIDVIVFVLSAENRLTLSAKEFLVNASHEKACVFCVVNGWDRISEKNKEKCKKGVLDQLKSISHETWMDREELVHFVDSTSVETDQDMDNSSRFARLEESLRNFVLFNRQKSKLAPAARFLSHLLSDVELLSKANVKVADEELEAAKNELIRVKPILEQMREKRESLQNELEKIENDAVEKLGKYTRKEIENALNEIGNGRLASDKVSMPVYQGLLSIYPYARAVKHALLESLDITIKDVENQVRDVTGDSVTLVQTVGNEALPEGVERVKRIFVKEAMFKSRSKSVSTVGMNLSRKSQNIEISPREIFDTTQFLIFRKTGDKKIDEDEDEGSFLGGLSLAVGAITMVGGKTMGMRGFIEGAVRISNLWGSDRVRQWAAPAISVLVVGAATYYIFELPRMIPRTIGTSIKNSLEAAPEPSITGDHTTDNYSEIHQLRVERETRKVLRLASWDVKEKFRATLETHATECQRAEQGEAKAKRAIEWFENVCNKVEGLRKLGGLSIPMEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y3</accession>
    <name>I4Y5Y3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960525.1">
        <property type="nucleotide sequence ID" value="XM_006960463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y3"/>
    <dbReference type="FunCoup" id="I4Y5Y3">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Y3"/>
    <dbReference type="GeneID" id="18473059"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58743"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012944_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y3"/>
    <dbReference type="OMA" id="MAHIVLF"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="770" mass="87032" checksum="09FF00797073BB70" modified="2012-09-05" version="1">MTVYQDFARILSEISNNQSNSVLELPDLFAQLCEKILKTNIDQSEREAWSLERNTWNLIHALYDDRLNGLDDGLSAKEILAANKYTPPLTLTQPLISQSKELMELNAIRQWLHNIPTPLYPVEIRKGYQTYTKNKLKLAVRQGNTTTGLVTSLDPDAPVRQHKQLDVEDSQYDKPLTRTLFEYVRLGRMDLALDACRSSDQPWRAASLRGGQLWDDPSLASEEIALNNGISGNKQRKLWKQIASQLSENPDFDPYERALYGCLSGSLSSVLPVCNSWEDHLWARVNALMERKIDDSLKKTGGYWYDNVDTVKAQEGEQVAEDLEGIFEEILKLGGDVGNSAHNPFRITQTNVMLERTSHLLTNFASQIQQTASMLSPDAFAHLLRFFAHLVLFLRAIDGENPSEDVPNGPAEVILEAYVRTLEQRNESKELVGMYAGCLGEGAGGESFAHYLYSLDIATPIDVRKAALLQTLEHGLDLERVACRTVELTLIDTFARLPEIPIDAPDITAFANTSGLSYKDLSLVRSIEWLIFAKETYRYALIQSNGLMRYFLTSGNVSAAFKLLESLPADLMAYQPNSKTEEDDMISIDDQIVEYSGYQQLFELLDSHTKLVELWTLQPDTNKVAKLDYKAWSDQVEALTHIVKEKTMDIFTTEWMRLGADAHEKRVAELERIREIYIPELVHRLHSSLYSAKSIHIRYIDEALNLANTVADERYCIYLEFVRRSTSLSKKGVAGSNTLASYLSLVKSAALSKLHYEELAGIPTDVFKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H0</accession>
    <name>I4Y6H0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_41109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960360.1">
        <property type="nucleotide sequence ID" value="XM_006960298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H0"/>
    <dbReference type="STRING" id="671144.I4Y6H0"/>
    <dbReference type="GeneID" id="18472203"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41109"/>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_2_9_1"/>
    <dbReference type="InParanoid" id="I4Y6H0"/>
    <dbReference type="OMA" id="QMFIGAV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="457" mass="51430" checksum="FD92D8EFFB330F65" modified="2012-09-05" version="1">MAEFENTKFIGATDDPWQLFSNNGQDYTIMNPIGYGASSIVYAAKFNGKDDRKESMCAVKVINVDNFNRHTLELLRRELQLLSLSKHSQVLRVRGMWMDGPKLHIATRLMKAGSVQSILRDAYPHGFDETVIATILKQALLGLQYLHSNGFVHRDFKAGNLLVDENGTVLVGDLGVASNLNEHDGSTKSHHPASIPPHLGRRQSFVGTPCWMAPEVVERKRYDAKADIWSFGITALELSLGHPPKAKLPPVTILMKTIHEESPTLEQNQVNSKSYSYSDGMKRVVDWCLRKDPNQRPTASELLASPWFTNKAKKPSYLVSTILDGLAPLTERIEAKQNHTPHMTRSDSFGWDFTMMTHNSNGMNSVDRRRQLLNHSYGESTIIDKEEEEGIGGAEEDSNSSESDPKPLTPPTIPTALPITERENIPEQEHLNKRYTDNTNKRKSLKTKFNKVMNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U3</accession>
    <name>I4Y6U3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960193.1">
        <property type="nucleotide sequence ID" value="XM_006960131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U3"/>
    <dbReference type="STRING" id="671144.I4Y6U3"/>
    <dbReference type="GeneID" id="18474458"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61316"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y6U3"/>
    <dbReference type="OMA" id="DRNSHAN"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="468" mass="51760" checksum="8A16E997C7136A52" modified="2012-09-05" version="1">MTAAVTRNVLVLGGSYAGGRAARLLSQQLPPTHRVILIDRNSHHNHLYVFPRYAVVKGHEHKAFIPYAKFENKKTDSASAESKSLKPAQKVLSRPHLSKEMHRVDSTSNILLDSGPQNPTDGKDHIILHAAVESIGPNSVTLSKEFPEHDLTNVVEFDYMVYALGSIMPVSLQMDQKTLKDGTKASGIEWLQHRQRVIEQNDRVVVAGGGALGIQLATDIKNTYPNKTVTLIHSRDRLLPRFDAQMHDIIFESLTKLGVETILQDRIELGSNTTLDFDGHVEEKRVFTRAGKRIECDLVLMCTGQKPNTELIRQLSPSSIDPQTNLVKVTRSMQLAALEKTEDIPESNAKRDILTSLKDSYEGLQASKYPHIYVVGDAADAYGALHAGHTGWNQSEFAVGNIIRQINDEKDDPKLYYAGKPAIKLTTGLNSAVIQLGDDITVNDNCPIDLDAASAWRFSGADTTDMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U4</accession>
    <name>I4Y6U4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960194.1">
        <property type="nucleotide sequence ID" value="XM_006960132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U4"/>
    <dbReference type="GeneID" id="18473032"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58560"/>
    <dbReference type="eggNOG" id="ENOG502S36V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_25_0_1"/>
    <dbReference type="InParanoid" id="I4Y6U4"/>
    <dbReference type="OMA" id="EDGATIW"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="275" mass="30612" checksum="569D728DAF6F69AE" modified="2012-09-05" version="1">MVEQTTTFKDGSKVAYNVFNEGATDKLPLVLIMGLSGTMLDWQMFAEGIAKAGERKVVIFDNRNIGNSYGEIGAMTLDQLAGDTIELIEHLNLKEIDLLGFSMGGMIAQQILLNRAPNFKINKIILASSACRSPPSTKIDMSSEKGAQAFTLSLFDEEWVKNNTAIIALIQETAALKRRPLETMQAQLKSLHGLDFSEQLSKSDFTDKIYIMHGKRDAIIKFEEAEYMLSTIKGAKYVNNLPSVEYGHMFPVYFDPKTWSDAIESCLCNSKKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U9</accession>
    <name>I4Y6U9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_21841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960199.1">
        <property type="nucleotide sequence ID" value="XM_006960137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U9"/>
    <dbReference type="FunCoup" id="I4Y6U9">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6U9"/>
    <dbReference type="GeneID" id="18470902"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21841"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6U9"/>
    <dbReference type="OMA" id="IVAHAWC"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="287" mass="31721" checksum="A390EE5193134DDC" modified="2012-09-05" version="1">MAGNTHKFNQVDVFTDTPYYGNPVAVVTVNGSLSDSQMQRFANWTNLSETTFITPSDKADYYLKIYTPASELPFAGHPTLGSAYVYLNSLKEEERQDLKNKGGTITQECGIGIVHLKWDYRTNLLSFQAPPLLRSDDVEQGHVEKVCKCMGISRDDVIDAKWVENGPPWFGIQLKNAQKVLDAAITDKEIVSGLYFGLFGEYEEEKSDVKFEVRAFAPLADGVGEDPVTGSFNAGIAKWLQNQTPKHYFNSQGTKLGRRGRVSVTEEGGEIYIGGNVSECIAGNVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X7</accession>
    <name>I4Y6X7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960227.1">
        <property type="nucleotide sequence ID" value="XM_006960165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X7"/>
    <dbReference type="GeneID" id="18474466"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61331"/>
    <dbReference type="HOGENOM" id="CLU_1161925_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6X7"/>
    <dbReference type="OMA" id="TERYQSM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="239" mass="26006" checksum="7B81B60ECD5F1E8A" modified="2012-09-05" version="1">MKSQQARSFVSSVLFSTERYDGLTVKSLQNELKKRKLPVSGNKQALIHRLGANDHQISTSTTQFSKRVVSEEGKDVNAPPEVPPSTVEGETTAPGQPLTSESSLTKSKVENLGAFTFIIPQPARIVDTKKVKIPVLATNWAATADTISAQSSSDVPKLSTASGISNINHNLYDLENELGDTVDISNSYLRKYLEKFTPKFEPAPKFETITRPLSVDEKNGLVRALAVVAGLFALSYANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Z6</accession>
    <name>I4Y6Z6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_33869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EIM19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Z6"/>
    <dbReference type="FunCoup" id="I4Y6Z6">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6Z6"/>
    <dbReference type="GeneID" id="18471763"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33869"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Z6"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="415" mass="46479" checksum="C97BED2572D13555" modified="2012-09-05" version="1">MGFAGNSEPSFVFPTVMGLPHSQSAAGSSGPGRPSAASKPSHLASKRGIDDLDFYIGDEAIQNSKSYGLNYPIRHGQIDNWDLMERFWEKSIFQYLRAEPEDHHVLLTEPPLNAPENRESMAEIMFESFNVQGLYIAVQAVLALAASWTSSKVTDRTLTGTVVDSGDGVTHVIPVAEGYVIGSSIKHIPIAGRDITNFVQQLLRERGETVSIPPEDQMRVSEKIKENYSYVCQDIVKEFRKYDQDPYNWFERYQGEHSVTGRQYGVDVGYERFLAPEIFFNPEIYSSDFLTPLPNVVDEVISSSPIDVRRGLYKNIVLSGGSTMFDHFGARLKRDLRQLVDTRLTKSELQSGNLQKSSGVEVNVISHKRQRHAVWFGGSLLAGLPDFYTSCYSKADYDEIGPSICRRYTIFGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y729</accession>
    <name>I4Y729_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y729"/>
    <dbReference type="GeneID" id="18471746"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33781"/>
    <dbReference type="HOGENOM" id="CLU_344395_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y729"/>
    <dbReference type="OMA" id="HMISQPN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="822" mass="92879" checksum="CA34D1ECD6F476A6" modified="2012-09-05" version="1" fragment="single">MKHYRVNSDESFNQNKSTSYHKQQMSLNNLNEIRILMVSIVGGSWNPVDVSNVFNHAKARNAVLVCLPIYEEDYPYCNFYLTDLFLRQTSPQAITNSELDAILTSHTSRNSSQNVLAHILVKVERPKSVTNTDTTLPLSLRPGRQPRPPSSAGRRSTSGGNSRLDDFGAPITSPSVEKEQHALLSKFEQEQRDHELAQKLQEDLRIEDERAREEHNRKIERQQRQWAEQVAGCEMPHSEVDLARRRHRERERLLLLRERERLQQQQQQTERKTFSSYPADQRRLQKSSRHSPYPAPQNIPMTSPAWNTRPPITTSKQSAYTRAYHNQRPAQFPTTPGVPSIPPPTRQTALKNQSSLQTARSMGNIYENYHNQENSKVFPAVLPNVSAGYVKQGKSKAPVYVSSQQPQITSPVAQRSIYSPTNSYPVHQATLTNHPSHPPAVEPSNASPYSNNARAPTRPYSEEELNWLYRMNQQIDEQQIRSQNSSQQPYVSSPNSAILVSPGYNGSNLASSNNPTQYLTTSPNSDHSSRSPSANDGLYITGIPKPRQANNRAYSSTNKMRPLSVEDNTIDKYYQDESVLATSAPANHPKISSFSDQQNSPQAEHEPRTIYRNHHNQDSSISSIPDERTSSSNRSSATSVDPLTPASDINSPAYQDRLISEEDQEFLLEDVTNAYFKESDNSESDYDGEVASGEDYLSTTDDDDEFGWKIKPAYQYDKTSIKSSQNATPTSPEMPTIIPSRSNTKEIEHQQHKSPSLDTVKDYNTHDSTSEDEGQATWQLPPKIISDKLHESNINNSKQEKRKLQLIIPESNVLTSEPQTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y746</accession>
    <name>I4Y746_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_48488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960122.1">
        <property type="nucleotide sequence ID" value="XM_006960060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y746"/>
    <dbReference type="FunCoup" id="I4Y746">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y746"/>
    <dbReference type="GeneID" id="18472452"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48488"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y746"/>
    <dbReference type="OMA" id="AWIISNK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="130"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="359" mass="40746" checksum="6E4B4CE1BA2E86F2" modified="2012-09-05" version="1">MVDSHKIKNKIKRGQIVEAAKKAKGKNKLEKRLKNKKEETEEEAEERRSKNVPNTLDNTREFDATIPQAQPVTQDNDQSQEEQPDNGGTSDALGTDDPELASDIANDAFATYFTPQLVNPDDPNSPIKLPKILITTSVGAGKNSIEFCMDLTSVLPNSEYVKRRGGKGYEIATIAGWAKKRDYTDMMVINEDHKTPNAITLMHLPYGPTAYFKLSSVKLSKAITGHARPTPHHPELVLNNFATRLGHTVGRMFQALFPPVPEFEGRQVATFHVQRDFIFFRRHRYAFKSTEKTALQEIGPRFTLKLRWMKRGLPSIKYEVDNRPTEARLANAADNDNGNDGFEFQWKPELETSRRKFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y751</accession>
    <name>I4Y751_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_48496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960127.1">
        <property type="nucleotide sequence ID" value="XM_006960065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y751"/>
    <dbReference type="STRING" id="671144.I4Y751"/>
    <dbReference type="GeneID" id="18472453"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48496"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010840_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y751"/>
    <dbReference type="OMA" id="PACTNWK"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="126"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="342"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="594" mass="66797" checksum="CC4460F3D32392F4" modified="2012-09-05" version="1">MTPKGGARESIPLSIKTNDGLLDNLNNPNGPITTLPLEILIHILRLLNNPTHLLNALLVCRTWCACSIEILWHRPSFPAATPYVKFAHILGGLYPNTPTFHYSSYVRRLNFSNIHNWISDPYFLPVAKCNRLERLTLTGCKNLSDSSLEFVLESCKNVLALDLSGITKMSDKTLKVISKNCKKLQGMNLTDCDGVTDEGVSELARGCKHLRRLKLCNLRQLTDVTVVEIAQNCPDLLEVDFTKCSISSSSVSLFWKNGINTREFRLGQCAFIDDSAFPSPPPPTTTPYQYTLVSQPQVKHFEVLRHLDLTSCTSITDEAIKGIIAHAPKVRNLVLAKCSNLTDIAIKNISKLGKALHSLHLGHVTSITDESIIVLARMCTRIRYIDLACCPNLTDNSITELARNMPKLKRIGLVRVTNLTDVSIYALCDTYTQLERIHLSYCEKITVNAVHFLISRLQKLTHLSLSGIPDFRRPDLQRFCRAPPKEFSEHQRQVFCVFSGKGIHDLRAYMQEEYARVRRGDILFEELPPFHNSSNGGSDTNLPSISSILRPRPNRLFDVLGLSNSDSQQTSSDADVRQLGLHSLEMQQQDYFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y766</accession>
    <name>I4Y766_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960142.1">
        <property type="nucleotide sequence ID" value="XM_006960080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y766"/>
    <dbReference type="STRING" id="671144.I4Y766"/>
    <dbReference type="GeneID" id="18475075"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65998"/>
    <dbReference type="eggNOG" id="ENOG502S3F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y766"/>
    <dbReference type="OMA" id="DCVEFIR"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="33189" checksum="E006E32A02F7756C" modified="2012-09-05" version="1">MKSSYTYKKINNLEIKLDVHIPPSATAENPAPVIVWYHGGGLLQGSCERYPNHFDVAVQERGFAFVSVDYRLAPQADFEEILSDVSDSVSYTIEELPGQTGHRIDVKRWFVSGSSAGGWLSLLVGLGVANPKHIPLACTAIYPITNTLAPFWNTLHEKAEWEDGPVAHETVKEHLNVDAPVVSSNPSNSTRSKMYAWMVQSASLNELLYGTKKDRAGNYAIINVLKEKKDATPPIYIIHGTVDTAVPFSQAVEVVDALKARNAEVQFDVAHDKDHLWDEYDKNERMDGLYAFIRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y786</accession>
    <name>I4Y786_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMEM14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960162.1">
        <property type="nucleotide sequence ID" value="XM_006960100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y786"/>
    <dbReference type="FunCoup" id="I4Y786">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="18473028"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58539"/>
    <dbReference type="eggNOG" id="KOG4267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096652_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y786"/>
    <dbReference type="OMA" id="ALATWYY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="10946" checksum="11E20996378FBB47" modified="2012-09-05" version="1">MSHHPAYTLAGLTGLGGTIGFLKKGSKASLIGGLICSVAFAGSGFLIQENRDYGHEAALASSALLTLSSIRRARKGARLPQFLTALGLASGAYYALKIKQFQDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B0</accession>
    <name>I4Y7B0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_55423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960186.1">
        <property type="nucleotide sequence ID" value="XM_006960124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B0"/>
    <dbReference type="STRING" id="671144.I4Y7B0"/>
    <dbReference type="GeneID" id="18472728"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55423"/>
    <dbReference type="eggNOG" id="KOG1894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006940_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7B0"/>
    <dbReference type="OMA" id="GKPMSAF"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="768"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115635" checksum="BAC676D08DC5C030" modified="2012-09-05" version="1">MSKEEILQEQEDIEEKLGAKMVEFLRKRAAKKETIDEQPIGDVYEQQTLERKQEDAGKEEFREGAAKVQRKSVRIQEKQPADDHQPDSTQLIIREKYFPDAKYNEDQHSWLTSLPPPSEESKGDTLRFDFHGNLMTGKKEAYLEGMHHHGLDQGSPGYTVDEFLMLSGSTNISQRILSLRSLSHILLKWYKREYTDETVQKLDYVQLGKAILSFRFAMSESNKSVVVAGLSGIASIVLEELHLDKHLNNGLTHAESASSTLKVYSGQLNLQPSEMKELLSTPLAFLTFRTDLADTLNDLLKGTAVIAGDNNEIKKVANIIFALSKHSIKTASECVNTPLFIERIVKTFIEKDWPSDEKPDSLAISALSAIAAASRSNASAIRSGKAVDVASRYLIIPPFKTSRKDAWFLAIESLVLMRTMANYGIVQGVSAVELISGDCIRWLSNQKEELPSHSSAFIKALFETLEMWTICAIDPHHTSPHHIIVWTQVESFIDMALAALQGVRDELTLASVWSYLSIWLRGNKGVADKAKWLEEYINIEDTKKTFDHHSQTAINLLAQDDYENAASSLCIVNATTRLLSHSGPYNLPKELIDVLLNTVTETNTATYNKLRPGLDALCRSILQSNLDNTENIHTALQLLTVLREGDESIVVAVLSHLLQNASPQVISTVTGFPEREAKASKETTVPLLIETAKLMLVDGIYSGISIHSNHLSQISTLTIPFDANTLLYENWALKITLDELSQSANSEALKNLPAHWNYSEVDLVMGGLTLQETINKIMGTSCSKQLLQLMRIFLLELGVEGGEVFRNERVQIALERTLHKVLTGLENDKYTLEDAQEEARADIPFYQIYTDYVGLFESISLGDRNTAIMLFPPLLLAQEYRRLLWVDHATCVKSIKLTWTDFPKWFVNKLLFPLEHNVDVIRAYARAISTKSLVLNIQPLAYWIALHHSSLCLWHTQDEALRRDLIVALLSTHPETAKMVIQYDNDEHNLKLPGQAKASPEIIQRRLDCLKDNDETLLSAKLGSILSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7E6</accession>
    <name>I4Y7E6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960030.1">
        <property type="nucleotide sequence ID" value="XM_006959968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7E6"/>
    <dbReference type="GeneID" id="18474412"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61239"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y7E6"/>
    <dbReference type="OMA" id="DIHARPC"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="101"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="34766" checksum="DDC31C93BC5F710B" modified="2012-09-05" version="1">MTAIPSQPPDAAIKASQREYTKEEEEKYTNLLSQVKAITELPNDENSSEKTALTATEKFWLTRECLLRYLRAVKWDVSAAETRIKKTLIWRRTIGLGEGGKLTTDAYILPEQLTGKQLIWGYDNQSRPLWYMKPDRQNTEESPRQTDHAYFMLETAKILCPRGVETVSLLINYAKKAKGPSLSTSKSVMYNLADHYPESLGTAFVINLPTVVTWMFKIISPLLDPVTRAKLSFKNDVSDMVDPSQLEDSFGGKLDMSTYNHDDYWPQLMGLAQERKKKIHQRWTELGEDIGISEWDLKDFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7L8</accession>
    <name>I4Y7L8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_65910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960098.1">
        <property type="nucleotide sequence ID" value="XM_006960036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7L8"/>
    <dbReference type="STRING" id="671144.I4Y7L8"/>
    <dbReference type="GeneID" id="18475067"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65910"/>
    <dbReference type="eggNOG" id="ENOG502S731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564064_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7L8"/>
    <dbReference type="OMA" id="QRWHIYL"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52775" checksum="B173D68233F7A53A" modified="2012-09-05" version="1">MSSETVPLLGKDREKNTGFYSLIPLIFAFSFSQQEILPSAVDTIKRISCYVNGADDCNDEAVQKLSASIVAAYGSINSIMVVISIIITTSMLDKIGIKKVLYAILIQAIIASITLPLAVHSSPVVSVILMISFAVTSAFGGQTAFGFAVATLVSNITHVSDRTTKLSYVEGTAFFGLTIASAFGGYLPAITGNFLSPYYFSFFIYSLCLVYLHYFISDSPHNGDLELQDVEQVKQTFTTALKDFFKPLSIILGRGRSKMNPGPLLLCLSVFILQSGSAFTDKTLIQYLSERFGFDTSRTGFYLSLLTGFKAVFLLIVFPAALPYLKRKYEEWAIHKKYVENGNENPRQEEEEVIEHVEEPASFFEVIVVRFSFTIEAFITLGIGLATNAPTVAVMICFLSVGSGSLPALKALMIAFSPSKRDRAATLGALYMVDAVGQVLSPIALGGIFAASVSKHPGLVFAVSAILIGLSTVPTYFMKDKDINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7M1</accession>
    <name>I4Y7M1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_21333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959894.1">
        <property type="nucleotide sequence ID" value="XM_006959832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7M1"/>
    <dbReference type="FunCoup" id="I4Y7M1">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7M1"/>
    <dbReference type="GeneID" id="18470884"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21333"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7M1"/>
    <dbReference type="OMA" id="KWWFSAH"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="2">
        <location>
            <begin position="283"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="451" mass="51461" checksum="2BE915027C0053CB" modified="2012-09-05" version="1" fragment="single">IAIEGCAHGSLDIIYRSIAENDKLTGHKTRLLLICGDFQALRNYADFNTLAVPQKYKQLGDFYNYYSGKKTAPLLTICIGGNHEASSYFWELYHGGWIAPNIYYLGRSGSVMVDGVRISGYFEKIPYNNYTLRSTYHIRQFDVAKLSFLPKPDIFLSHDWPLSIERYGDTNKLIQKKPFFENEISRNELGSPPLLTLLEKLKPRQWFSAHLHVYFKAKWISVVDSIDPADSTSNDTSNVGNPDEIAIEDDDRPDDAVAENKDGNPEEIVIEDEIDEGDVNVEAQSNDKRDIINDQETTYFTALDKSLPKRKFLEVCLETTQELQSEKPSFTFDPHWLAITRAFHPFMTIGEDQLELPSDEDAKREIATQLEWTNEYLSNVQVESIQQFVKTAPADGDKGFTYKGQPLAYTNPQTENFCSMLEIPNLVNPQPYENLTQPEYQGEGLTSKEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y801</accession>
    <name>I4Y801_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_33549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959814.1">
        <property type="nucleotide sequence ID" value="XM_006959752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y801"/>
    <dbReference type="STRING" id="671144.I4Y801"/>
    <dbReference type="GeneID" id="18471705"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33549"/>
    <dbReference type="eggNOG" id="ENOG502RCNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033907_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y801"/>
    <dbReference type="OMA" id="WSGPRNL"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30736" checksum="E7CED614B7C6FA4E" modified="2012-09-05" version="1">MTIHKPLLVLSVPRSTSTALERAFIQRENCHCFHEPYYYGPERLSDRYNDEQRAASGYENLTYQDIIDQIKSKSMEDPGRLIFIKDMAAYLVKPELMDKADVINPTILSDDQLKEFRYAFLVRSPRKAITSYYRATIDNDCGDFGEFDPSEAGFKELHAMMKYIRKLNPDDGIALIDSDDLVNNPGKTLQLLCDKVGIPFEDNMLSWESKRIEEFDKWKGFHEDAQNSTGFKAVKREKIDLPDFVEEAIKDNEETYNQLLKYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y832</accession>
    <name>I4Y832_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_40378</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959845.1">
        <property type="nucleotide sequence ID" value="XM_006959783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y832"/>
    <dbReference type="STRING" id="671144.I4Y832"/>
    <dbReference type="GeneID" id="18472168"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40378"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y832"/>
    <dbReference type="OMA" id="LYNCNYF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM20124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="518" mass="59505" checksum="00F5825389F1E500" modified="2012-09-05" version="1">MKTFTRNAVAEHILQGQILVIYKSKVLRLNSWIDKHPGGDLAILHFVGRDATDEISAYHDDATIEKLLPRFIVGQLDESDSEPFYPLIPPVQLGWRGDKREGHTTQAIGRFNGSGNNTEDKEIEPHLPKSKFANIPLTMQELEPPTPTDESLDIKRQFKISQNYHKLHAEVKRRGLYTIQSDAYLYECIRYTALLVIFALLYFKLEWKVLAAIPLGLFWHQITFVVHDAGHCEIWGSQKTDKTLACFIASYIGGLSANWWCDNHDIHHIVTNHPEHDPDIQHIPFFAISTKFFNSMWSTYYRRVMEFDAFAKLVLPIQHNLYYIVMSVARFNLFALSYIYLLTKSKNDWYRNFEIVGVSVFWTWYGSLISHIPSHFGKFAFLLLSNVAASPVHVQIVLSHFARSTDDLGLTESFAHRQLRTTMDVACPWYLDFLHGGLHMQVSHHLFPRIPRHNLREVRDMVAKFAAENNLEYAEHGFVAGNGQVLDVLRNVGEQVKFVSKVAASEASQKMHKTAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A2</accession>
    <name>I4Y8A2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_52248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959682.1">
        <property type="nucleotide sequence ID" value="XM_006959620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A2"/>
    <dbReference type="FunCoup" id="I4Y8A2">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8A2"/>
    <dbReference type="GeneID" id="18472578"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52248"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8A2"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="68" mass="7430" checksum="58744BEFD1080A88" modified="2012-09-05" version="1">MDAPAANKQPVKLAKVTKVLGRTGSRGGITQVRVEFLDDTSRSIIRNVKGPVREADILALLESEREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C9</accession>
    <name>I4Y8C9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein phosphatase 2A regulatory B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_21001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959709.1">
        <property type="nucleotide sequence ID" value="XM_006959647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C9"/>
    <dbReference type="FunCoup" id="I4Y8C9">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8C9"/>
    <dbReference type="GeneID" id="18470865"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21001"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y8C9"/>
    <dbReference type="OMA" id="LIYPEVI"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="478" mass="55655" checksum="1472F0D5C7DAE7C3" modified="2012-09-05" version="1" fragment="single">MKSLKKLGLSKSKSNNSNTPKKSDNPGILVTTELPQDPIPRPSHGHLDSTPPKSTRIQSPKDTIPITGKPPKKQRSSRFHVTHPQNLEPLPAFLDVPLQDRTSLFIKKLHQSSVLFDFNDASSDLQGKQVKAAALHEMLEYLTRNKNVITESIYPEMVHMFACNLFRSIPPPVNPYGDAFDPEEDEPICELAWPHLQVVYELFLRFVESPDFNTNIAKRYIDQLFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSINNVFFHFIYETERHNGIAELLEILGSIINGFALPLKDEHKTFLTRVLIPLHKVRSLSLYHPQLAYCVVQFLEKDSTLTEEVILGLLRYWPRVNSQKEVMFLNEVEEILDVIEPAQFQRIMVPLFHQLSRCINSQHFQVAERALYYWNNDYIVNLMSNNLPTILPLVFSSLYQNSKIHWNRTIHNMVYNALKLFMDMNPPLFDECTSNYKPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K2</accession>
    <name>I4Y8K2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959782.1">
        <property type="nucleotide sequence ID" value="XM_006959720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K2"/>
    <dbReference type="GeneID" id="18474331"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61097"/>
    <dbReference type="HOGENOM" id="CLU_162195_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8K2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045992">
        <property type="entry name" value="DUF5948"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19373">
        <property type="entry name" value="DUF5948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697706" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="95" mass="10455" checksum="D4B57E0B8B68AFB9" modified="2012-09-05" version="1">MKLSVFSTICVVPFAILGLINSASADHIGACTKDDGSYAPYWTKECCRIAADQYSIPYYYRSEGDCGSRITADNRLNGKMFSKCCSNRNLGYASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8P3</accession>
    <name>I4Y8P3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-subunit processome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_69896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959592.1">
        <property type="nucleotide sequence ID" value="XM_006959530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8P3"/>
    <dbReference type="FunCoup" id="I4Y8P3">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8P3"/>
    <dbReference type="GeneID" id="18475660"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69896"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003783_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8P3"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="909" mass="101989" checksum="8CF80666759C57AC" modified="2012-09-05" version="1">MSMRGLISDSQMAKPKTNQKRQTQKAEKQQRYKKGDELNVFELVQDDDNKRRSNLTTKLDKDEDYDQRGGEDDSDDERMRNIKIDHLKEGIVNESDDEEIDSDDAFEESDEEKYADWTFTGSKQSNKKKNTKFDNVDEEDEDEEEGMVDLDTMLDDDQPIDEQITKDDVDDSDIEYEEDDDQGDSTKLTDLVNSLDPSARKSYKPDASMDDDGFVAGQNSEFRVPADGPVSLDSLLAPLPTGIAATIDQQVKPLKPSESKTAKRGALSAPLATFFKERADREAGQKVVKDDVKQWDSTMRALENSNTLSFPLQGPGQGGLEDGSKAGGDLVGRFQPSNPLESSVDELLKSNNLTRKVAPSDSLPEQDESKLSKDQIRAKYQALRQQRQLMYESEKKAARMNKIKSKTYRRLKRKEREANKQKALEAGVIDSDEERMNVERQRALERATLRHKGGNSKWAREMKDRSEGDRDVLNELHRMEELGQRIRGEKADNEDDDDSDYSVGDNDDEDAVKLAALNKMRSLQQKDESTADEKFKGIAGMKFMRDASARENKAMEDEAEEFAKEMRGEGDDDSERMTVGGNPGRFVVGAGKKSKPTTEATNDDDDEEPGSATSSRTLGRELEDTRADNKAISFDKFKEQYERDNDDDNDDESNPWLTADNEGGIKRAKKKNIATVSKASKKVDKSQADFKKRKRANQGANEEEAIDLDLDATINKASKNAAKKQKRKSGQNAQDGFASESDSDEDIVGGGVQAFKQRDLVAEAFAADDVVQNFAEEKKQEIEAEGPQEVDTSLPGWGNWSGKGVKKNKAAEEKKRAKFLKKTAGVEADKRKDADKGHVIISEKTEKRSLDKYSLKDLPYPFTSRSQFEAAMSNPIGQEFNTTSSHKRQIAPKIQTKAGQIIKPIVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y931</accession>
    <name>I4Y931_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_39884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959499.1">
        <property type="nucleotide sequence ID" value="XM_006959437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y931"/>
    <dbReference type="STRING" id="671144.I4Y931"/>
    <dbReference type="GeneID" id="18472137"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39884"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024324_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y931"/>
    <dbReference type="OMA" id="WSLITLD"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="224" mass="26358" checksum="C398A4E4FAD64030" modified="2012-09-05" version="1">MSLSGKISKCGRQTMMSNDLKTLMPRQWLNDEVINFYAEMLRQSQSRQIEDWEKHDKKDKKPFDAYIHSTFLFSTLESSGYDKAKLGRWVKKVDLFGKDIIIFPINRGQSHWVCGAINMRKKRFEMYDSMGGGTKYVYQKMREYINREHETKKGKPFDFDGWIDFWSENTPTQDNGFDCGVFTCCFMDALSKGKDVDDDAFEFSQKHMKYLRKRLVLDIAMSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9B4</accession>
    <name>I4Y9B4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959350.1">
        <property type="nucleotide sequence ID" value="XM_006959288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9B4"/>
    <dbReference type="GeneID" id="18472982"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58065"/>
    <dbReference type="eggNOG" id="ENOG502S0HV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034766_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9B4"/>
    <dbReference type="OMA" id="IFRPSPM"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="371" mass="42480" checksum="DE75B338F444B3CF" modified="2012-09-05" version="1">MSQYFDYDLSMRQQPKHSRMCGVGSKADRRPIDPPPIVQLKVYSNHQNFKSRQDLSFNHFQSPYFFVYCSLAGEDSDEELHILSETKTRYTTGNVTSSIYCLRDLDLTEVLVAVFPDVSVRVEGRFRLKFSLFEIQNKTYHRKSLFSDPFTVFSAKRFPGMDQSTELSQCLANQGLKIRIRRDNRRDRRKSSKRYFDDEEEAGTSTNLNVPSIIPQQAQQLHNHTQPASNFKRPLAPLPSRITNIPDQPHEFSQSTLTRPLQSFPFESSSFRNLQTPSIVIPPYQSQRIHSSPVIYTRSDTSANDREVPPARPTLPSRQSFTQPTSVAATMSISPPSPQDSAPRIQLPPIRDLIQPPSTFNPSNFKPPNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F1</accession>
    <name>I4Y9F1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_20372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959320.1">
        <property type="nucleotide sequence ID" value="XM_006959258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F1"/>
    <dbReference type="FunCoup" id="I4Y9F1">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9F1"/>
    <dbReference type="GeneID" id="18470837"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20372"/>
    <dbReference type="eggNOG" id="KOG1002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y9F1"/>
    <dbReference type="OMA" id="DHIMLRR"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="60"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="483"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="74749" checksum="1DD19BF3FB694A1D" modified="2012-09-05" version="1">MLIALRNQVALACWHPELSDVWGDLSRDIEPVKPHKLPSPHGLKLKLLPFQQESLHWMKEQEKGTWKGGMLADEMGMGKTIQTIALLLSDRKAPNLIVAPTIAVVQWKNEIEAFTDGMKVLLWHGASRTKHKDDLKKYDVVLTSYAVMESAFRIQTYGRQKKGQKIKEPSPIHSLKWHRIILDEAHSIKERQTNTAKATFALESNFKWCLSGTPLQNRVGELYSLVRFIGADPFAYYYGKKSKCKSLNWSFSDRRHCDFCGESPMNHVCFWNNEILTPIQRYGMVGEGKTAFKKLKILLDRMMLRRTKVERADDLGLPPRIVKCRKDFFSEEERDLYLSLYTDVRRTFTTYIDQGTVLNNYSSIFSLITRMRQMACHPDLVLKSRTGPYGQEAPDEHVCRICNDIAEDAIDARCHHVFCRLCITEYLTGSLVSQPECPSCHLPISIDINQPSIETAEDEGLKTSKPQGIIGRLDMDKWKSSTKIEALVEELTELQREDCTVKSLVFSQFVNFLDLVAWRLKKAGFNICRLEGNMTPQARNAVVQHFMKNVHCTVFLVSLKAGGVALNLTEASRVYMMDSWWNPSVEYQAMDRVHRLGARRPVECIKLVVEDSIESRIVQLQEKKSAMVEAAIGRDENAMGRLSPEDMSFLFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9G5</accession>
    <name>I4Y9G5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein COQ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_12608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959310.1">
        <property type="nucleotide sequence ID" value="XM_006959248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9G5"/>
    <dbReference type="FunCoup" id="I4Y9G5">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9G5"/>
    <dbReference type="GeneID" id="18470605"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_12608"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y9G5"/>
    <dbReference type="OMA" id="NPLWYGG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="183" mass="20366" checksum="F90BC3D6B9EAA107" modified="2012-09-05" version="1" fragment="single">ITTEQKDIIDKLIRVDHAGELGANCIYAGQMYATKKAGPGRSDEIELVQHMWDQEKHHLSTFNKLIDDFRVRPTVLSPVWIAAGWFMGASTTALGKQSAMACTEAVETVIGEHYDDQITQLKKFEHLHPDLVKLRETCEQFRDDELEHLDTAVDHGAQQAPAHALLSAVIGSACKFGVWAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M2</accession>
    <name>I4Y9M2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Ribonuclease H</fullName>
            <shortName evidence="12">RNase H</shortName>
            <ecNumber evidence="5 12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_54923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17 18">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5 12"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959199.1">
        <property type="nucleotide sequence ID" value="XM_006959137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M2"/>
    <dbReference type="FunCoup" id="I4Y9M2">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9M2"/>
    <dbReference type="GeneID" id="18472703"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54923"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y9M2"/>
    <dbReference type="OMA" id="IRSMTEW"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="14">
        <location>
            <begin position="89"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="264" mass="29512" checksum="9A235F8E84A70B65" modified="2012-09-05" version="1">MPKKNWYAVKYGKQPGIYKSWPECQSQTAGFPGAVFKGFENYDDALNFIARDSTKKKASDTMKRKAEDRPDIPTKKGKLTDNMSRAGIYDDSAVVYTDGACTDNGKKNPKAGCGVYWGKGSPLNLAEKVPGPNQTNNRGEMMGFIRALERCPANIKHLSIYSDSEYTINCLTKWRQGYEKRNFKSSSNPNEPIKNIDMIKYLYALYDNHTASIKIHWVKGHNKHPDNEAADELAVAGAKLPAKLEEVDWESLAILCSSSVDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9X1</accession>
    <name>I4Y9X1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_51990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959289.1">
        <property type="nucleotide sequence ID" value="XM_006959227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9X1"/>
    <dbReference type="FunCoup" id="I4Y9X1">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9X1"/>
    <dbReference type="GeneID" id="18472572"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51990"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y9X1"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="21315" checksum="2F29EDD696D268CC" modified="2012-09-05" version="1">MPGVSRQHKFSEYLVVGRRLPTEVDPTPKLYRMRIFAPNEVVAKSRFWYFVGQYRKMKKGTGEIVSVNVISEKKPLKPKNFGIWLRYDSRSGIHNMYKEFRELSRVDAVHALYQDMAARHRARFRSVQILRVAEIEKTEDVRRPYIRQLLQKNLKFPLAHNRNKNFRSEFQAKRPSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9X8</accession>
    <name>I4Y9X8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959295.1">
        <property type="nucleotide sequence ID" value="XM_006959233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9X8"/>
    <dbReference type="STRING" id="671144.I4Y9X8"/>
    <dbReference type="GeneID" id="18471629"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33176"/>
    <dbReference type="eggNOG" id="KOG2992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704368_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9X8"/>
    <dbReference type="OMA" id="ENNSGME"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="36867" checksum="213E828885E4956C" modified="2012-09-05" version="1" fragment="single">MVNSKELSATLLLVHAFLFANKLDKTASKLLKEIEEKNLEIDSSKLAKSKDDPKCSLILEAVTAKLEQAKKDTEDDSDSDSDSSSSSSSSDSDDDDKPAAEPASKEEDSSDSSSSSSDSEDEKPAAAAKKPSPKKAASSSSSSSSSSSDSSDSEDEKKPSPAAKKTSPVKKAASSSSSSDSSDSDSSSDEEKKTVVAKPAAETKKRKASASSSSSSSSSSDSSSSEDEKPVAKQTKKQKLDDNTTVETTESSTPNGKETTVTTTTTSANGKQKKVQNERFRRVIAEDVTFHDNRLADNSFEGIGLSEKDFGHKAAADLAPTKGAGFRKEKNKKKRGSYKGGEIFMGSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF2</accession>
    <name>I4YAF2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1771-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958938.1">
        <property type="nucleotide sequence ID" value="XM_006958876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF2"/>
    <dbReference type="SMR" id="I4YAF2"/>
    <dbReference type="FunCoup" id="I4YAF2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAF2"/>
    <dbReference type="GeneID" id="18471591"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32939"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062475_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAF2"/>
    <dbReference type="OMA" id="HERNMER"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="244" mass="27598" checksum="B89FE0E73438A27C" modified="2012-09-05" version="1">MNWVGILKKLFKICVKEIEDHQKQQDKPTQKPQQQKPTGQAVPEKEELGPKRIQGQAAEQYWQSRPEYTELRDKANKEGDLMRKCYDQSQDAYKSGDGARAKELSTEGGKHKQKRDDLNMQAADWIFEKNNLDNKRDEVDLHGLYVREAVEKTTQAIANARTSGINPIKVVVGRGTHSKNHVSKMKPAIEEMMRKENLRCKVDPSNAGQLIVYLDGQGDGGATNNASWTDEVENRTEGDACTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAI9</accession>
    <name>I4YAI9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958971.1">
        <property type="nucleotide sequence ID" value="XM_006958909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAI9"/>
    <dbReference type="STRING" id="671144.I4YAI9"/>
    <dbReference type="GeneID" id="18474085"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60665"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698484_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAI9"/>
    <dbReference type="OMA" id="HEEICIF"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="367" mass="40865" checksum="9FA7054FB2DA3DDA" modified="2012-09-05" version="1">MDIVNLVNNADTRKSSKNASTQPRPFACTYGNCTKAFARRSDLQRHLRIHLNERPFACPIDGCSKTFIQRSALTVHIRVHTGERPHTCEQCGKAFSDSSSLARHRRIHTGKRPYKCPVEGCNKTFCRKTTLTKHTKRNHQSQSSLSNSPSPSPSPEAQQSNVPALTIPQPLTQQLSQSPLQCLPITQPSLYALSQEEKPQFMDNSQFRLQSPICMSSYQSQESPSNSTVFSSPTTPTYATEAQFLYQHPPPPQGAFSYYESTSPFLYVDTSNQKSQMGLNNQSQLLTPPQSADPNNFGPFAYVPPPLAVTDDYNTYPFVPPSPPLTGNCETSYSNQSLIDESHYHHETYPHPNVLTGLGLDLVQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAN9</accession>
    <name>I4YAN9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_39215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959017.1">
        <property type="nucleotide sequence ID" value="XM_006958955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAN9"/>
    <dbReference type="FunCoup" id="I4YAN9">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAN9"/>
    <dbReference type="GeneID" id="18472105"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39215"/>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="InParanoid" id="I4YAN9"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="80"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="484" mass="53865" checksum="15E7AA8C6DAE47D2" modified="2012-09-05" version="1">MQFFETTKSQSNIIMHSNLPTPPPSHSTSPAPSDRQKCVYECLPNLYHGSTESQLAKNVKIFNSQPDFAEEHPFFVADLSSVYKQHIRWKTELPRIEPFFAVKCNPDPYVIRLLAGLGLGFDCASQTEINTILSLPTNCPATENPSNNIIFANPCKAASMIKFARGNQVKMMTFDNTDELHKIARLYPDAQLIIRILTDDSKSVCRFGIKFGAPLDAVPHLLKTAKDLCLNVIGVSFHVGSGCYDPQSYVDAIERSKKTFEVGESLGFKFNLLDVGGGFGHDNFELLARSLGPAVDAHFPVETGVRVIAEPGRFYVHDAFTLATNIIAKRGSDDDINQDLDDQSPKVMFYQNDGVYGAFNCVMFDHAEPKARTLTVQSELTLDDPLLNEKMVKNEEISCSIWGPTCDSLDCVMKNHKLSKGLQVGDWLRWDQMGAYTICAASTFNGFRKADVHYTSGADSEESHQVRKLLQQTAPDLRGLIMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAP1</accession>
    <name>I4YAP1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959019.1">
        <property type="nucleotide sequence ID" value="XM_006958957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAP1"/>
    <dbReference type="FunCoup" id="I4YAP1">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAP1"/>
    <dbReference type="GeneID" id="18475584"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69460"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAP1"/>
    <dbReference type="OMA" id="WPFHDLT"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="349" mass="39246" checksum="4BE92D9344171625" modified="2012-09-05" version="1">MMFTRALRISNSIRLYSTARPLAFAFDIDGVLKHGSFAIPEAKHALKKLDSLNIPYIFITNGGGTKESDRCKALSKDFDIHVDESQIVLSHTVMKPLSERLKNDNILVIGGDEHGQKCREIAESYGFKNVYVPADILSWNKFIYPFASPPAPQDAMAQPHTYQRKHVDFAKVPFSAVLVFKDSADHGLDIQIICDLLRSKDGLLGTENNQGKQGVELHFSNPDLIWTTEYPQPRHGQGMFIEALKTVHMIRSPEIELKYYQYGKPHAITYEYADNLLQQLLKSKTNITEKPRVIMVGDNPDSDIQGANLFGWQSALVRTGVYTHGIPKHEPSIIVDNVLKAVDWALSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB39</accession>
    <name>I4YB39_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_29096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958854.1">
        <property type="nucleotide sequence ID" value="XM_006958792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB39"/>
    <dbReference type="FunCoup" id="I4YB39">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB39"/>
    <dbReference type="GeneID" id="18471073"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29096"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="InParanoid" id="I4YB39"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="450"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="624"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="722"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="263"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="751" mass="83445" checksum="B2FD7017FD65B5AC" modified="2012-09-05" version="1">MNMGGAPSKGDTLKQYSVDLTELAKSGKLDPVLGRDDEIRRTIQILSRRTKSNPVLLGNPGVGKTAILEGLAQRIVNNEVPESLQGRRVLSLDLAGIIAGASFRGSFEERFKALLADIEAEQGKIVVFIDELHTLLNLGKAEGSIDGGNLIKPQLARGLQLVGATTLDEYRKTIEKDGALARRFQPVQVEEPSLGATISILRGLKSRYETHHGVIIGDDALVAAAKHSDRYISDRFLPDKAIDLVDEAASTLRLAQESKPESLAKLDRDILEIQIELQSLQNDDNALSVERKETLEKQLKEYEEESRNLTKIWNDERSKISDAKVAKEELERAFIDLEISQRHGDLERASRLRYESIPQLQRDIEIAEKQAEEGTTMLLVKDRVASDDIARVISRMTGIPISNLLQGEIEKLLHLEDKLAERVVGQDHIIKAVADAVRLSRAGLQSSSRPIASFLFLGPTGTGKTELSKALSGALFNDEKRSLININMSEYQEKHTVSRLVGAPPGYVGYEESGQLTEAVRRRPYSVVLLDEFEKAHPDVSNIMLQLLDEGSLTDSQGRKVDFRNTIIIATSNLGSDILTRPESTGPDENVTEEAAKEVIERVEKVYPPELLNRLDHILVFNKLNHKSIKDIAKLRIQEVNSMLGEKHMSLDVSEDVINHLAEVGYSSTYGARAIQRTVRSTIANPLAKKIIQGSIRDSETAKIVMRDGQVEIIDNHLPKPLDEALPKHVKAEDEESLRADDHDDPDQHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB91</accession>
    <name>I4YB91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_64501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958589.1">
        <property type="nucleotide sequence ID" value="XM_006958527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB91"/>
    <dbReference type="STRING" id="671144.I4YB91"/>
    <dbReference type="GeneID" id="18474933"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64501"/>
    <dbReference type="eggNOG" id="ENOG502SEE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044884_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB91"/>
    <dbReference type="OMA" id="ITTPHRL"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32880" checksum="169992BA5FEB2D06" modified="2012-09-05" version="1">MPLVSHPTPNMPDVSVWLMIPIVALGILIGVLVVLPILGVLTRHRANFNPKGLSLDPESNPTVGAKVDSYWSMAKRVKEVEGIPGFFKGLCPTLLSEVVVGFVALIPVPAILAGGFFGTLAAIVGFILVGCIALPFDIVIKRAIVTPYNLSISTPRQNIRKLVTPTEMANPLTMINSTLVQVLALRLVINAVTINIFRPVVSIIPYIGPIIWQIFTIALVILLCPLDVLQTRLMVQPLGQQDWDEETNHNKYEDAVVNIRQQPYHGVGDALRAIKDEEGTTALARGWWFTLIGQLSIAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC8</accession>
    <name>I4YBC8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOR2</name>
        <name evidence="15" type="ORF">WALSEDRAFT_60500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958623.1">
        <property type="nucleotide sequence ID" value="XM_006958561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC8"/>
    <dbReference type="FunCoup" id="I4YBC8">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBC8"/>
    <dbReference type="GeneID" id="18473988"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60500"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="I4YBC8"/>
    <dbReference type="OMA" id="CLESEYF"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000498">
        <property type="entry name" value="Serine/threonine-protein kinase KIN28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="352" mass="40209" checksum="52861CE810F68FF8" modified="2012-09-05" version="1">MEQLNNAIMKRYSKERKVGEGTYASVYQGHCVETGRMVAIKKIKIGQFKDGLDMSAVREVKFLQELKHENVIEMLDVFSAKQNLNLVLEFLTTDLELIIKDRSIIFRPGDIKSWMAMTLRGVDWCHRHFVLHRDLKPNNLLINDKGILKVADFGLARDVAEPGMKMTSQVITRWYRPPELLFGARAYSSSVDIWSVGCIFAELMLRTPYMPGENDIEQLNTIFRALGTPKESDWPGHTSLPSYIKFKDYPKQPLEDLFSAAGNDAIELLAKCLLYNPHERITAKEALRLPYFSNQPKPTPPPLLPKPLKQLEPRPLQPDVVAKQQGANKRKAGHEQDGKPDLRKVARKLDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBG1</accession>
    <name>I4YBG1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_64567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958655.1">
        <property type="nucleotide sequence ID" value="XM_006958593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBG1"/>
    <dbReference type="GeneID" id="18474941"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64567"/>
    <dbReference type="HOGENOM" id="CLU_2086657_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBG1"/>
    <dbReference type="OrthoDB" id="10312359at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="119" mass="12577" checksum="6D1D89178E77E4FA" modified="2012-09-05" version="1">MVALELKFTNAIGQIEASNVTSCVDCCVKYDTVDQPGNLQNGTYTGPLGDSPCSDEPPEYEKIRDGILLVGGDCDGTYIADCGYTRVVSNYLGPTSSATRQVPKIFAILAFGLAATVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBH5</accession>
    <name>I4YBH5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AIP1</name>
        <name evidence="5" type="ORF">WALSEDRAFT_28948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958669.1">
        <property type="nucleotide sequence ID" value="XM_006958607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBH5"/>
    <dbReference type="FunCoup" id="I4YBH5">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBH5"/>
    <dbReference type="GeneID" id="18471068"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28948"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBH5"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="456"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="609" mass="65370" checksum="A4F3AF688E92E3F8" modified="2012-09-05" version="1">MSISLKDTHPINPYSERGSATKLAVDAKGEKLVYANGRSVIIRDLKNPSKSFVYQGHIQPVTVARISPSGFYCASGDVTGTVRVWDIVGEDKVLKSEVKVTSGRINDLDWDGDSQRIIAIGEGRDSFGRAFMMDSGTNCGEITGHSKPGNAVAIRNKRPFRAVTASDDSTLVFYHGTPYKFVKTIKKHTKFVQDVRFSPDDSKFVSVGSDGSLFVFDASSGDIIHESLKAHSGSIYGVAWASDSSKFVTTSADRYVKVWCANTYNELLSYEIGQGIDNQQVGVVWPANSEKVISLGVNGTLNEIDVSNKDSITKGEIHGATRAITAFAQTESSLISGSFDGNLRSFTKEGGECKPIEGGSGKSVTKLFTKGISKDIGALTVGFDDKLRAVDTALSNTTTLSVPLSAFAKGLAADENYALVTCINDTIDIVEYKQGGEAPKKSTTVKYTPSAITLDKDLVAVGDETGKVHLLEFTNGVLGKETKTLERGRSEITAISFSPSGEFIAVGENNGKITVYDRAGEVKTSSWAFHTARITSIEWTADSQVAMTTSLDTNIYFYSIEKPSRNISIKNVAAGGLIGGVWTSDAKSIAVAGADGNIRTYDVDLKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBK1</accession>
    <name>I4YBK1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958691.1">
        <property type="nucleotide sequence ID" value="XM_006958629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBK1"/>
    <dbReference type="STRING" id="671144.I4YBK1"/>
    <dbReference type="GeneID" id="18471559"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32790"/>
    <dbReference type="eggNOG" id="ENOG502S3QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1066339_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBK1"/>
    <dbReference type="OMA" id="QWFSASK"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="251" mass="27390" checksum="FC40E5BA9AB56A2C" modified="2012-09-05" version="1">MSIVDNYEVDLLSSIYKSIQSKPITIPAHAKLNLCDREKKPHIVDIPMADIPTAEPSTSGSVPSELKFTVKNIKTAQKVDISTQSTSSIKDIKQAVVDAHLADSIDAQRLLLKGKALLNDKLVKDYEGLTSGATLTLMLRAPSAPPTEPASRQASNLPEVSLTSADNDSTRTAADPAIDSQSVKKSDYDKTLTDPAFWKKLSGFLNQEFKNDEYGRRALETFFLSAKTSLSPSEIAFIREQAGFEAMGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBM8</accession>
    <name>I4YBM8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958716.1">
        <property type="nucleotide sequence ID" value="XM_006958654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBM8"/>
    <dbReference type="STRING" id="671144.I4YBM8"/>
    <dbReference type="GeneID" id="18472942"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57668"/>
    <dbReference type="HOGENOM" id="CLU_555743_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBM8"/>
    <dbReference type="OMA" id="EEQMHRE"/>
    <dbReference type="OrthoDB" id="3365729at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56510" checksum="F43B42CD9EFCC2BF" modified="2012-09-05" version="1" fragment="single">MPPKKSTTKKRSSARNKTTKNDEIKQNELDLEQENSSDKAIKPVDNTTDKQSDDTTENQQKSHPEEDLEMQADKPSESDNKTLTDDANNPDKDTAMETTDEQKTEIKVEQETKQEDNQDSKQEVKQEEGNAVDKPTEAIIKEESKELNNDTLQGDAQEDKKDDKRDESKEVSQGDDKRDNQVDAQKENQGNDVDMKLDEQKDMQVDNQGEKIEITSKEKHEDDVQRSQEDAPESSKSPAKSKKREADTNISSSSKELKDNGVSETTEESHPPAPKRRRGLGAAGALFAKSFQQATRESRAPKSDALKRREEIEQRTQTRIQETNNKFKQVDQHESKLKKLKQDLENKEDQLHINEDTLEVEIKSLQRSAEFLLAPYFKNKTIEASVDLSKNDTKGIPLLLYRPTRLIKSQIEEIDQQKEETKERIEKIRKEFDIYKEKELNDIFELNKAIQEEATALKKFENENNAEEDKKEDKKDDAWEQAEQSEPMQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC68</accession>
    <name>I4YC68_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_32476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958259.1">
        <property type="nucleotide sequence ID" value="XM_006958197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC68"/>
    <dbReference type="FunCoup" id="I4YC68">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC68"/>
    <dbReference type="GeneID" id="18471498"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32476"/>
    <dbReference type="eggNOG" id="KOG4777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="InParanoid" id="I4YC68"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="360" mass="39064" checksum="9C4063088D2B7753" modified="2012-09-05" version="1">MNKEFKVGVLGATGTVGQRFILHLHNHPFFKLVALGASSRSAGQPYIKATRWKQSKPIPESVKDVIIKECTTENFKDCDIVFSGLDHDVAGPIESGLREAQVAVFSNAKNYRRDPLVPLVVPLINTDHYKIIPAQQEPLGLKKGYIVANANCSTTALVVPLAALEKSFGPLELVQATTLQAISGSGYPGLPSLDILDNVVPYIGSEEDKMEWETYKILGGINPDMKSFEYHQASPLKVSASCNRVPVIDGHMVCASVKFASPNKPTPEQVMEAFKNYKCDAQSVGAPSAPAQVITVHEEEDRPQPRLDRDHQNGAGVNVGRVREDSIFDIKFVVLANNVQIGAATSSVMNAEVAALQGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC71</accession>
    <name>I4YC71_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958262.1">
        <property type="nucleotide sequence ID" value="XM_006958200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC71"/>
    <dbReference type="FunCoup" id="I4YC71">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC71"/>
    <dbReference type="MEROPS" id="A01.078"/>
    <dbReference type="GeneID" id="18473884"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60316"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_2_1"/>
    <dbReference type="InParanoid" id="I4YC71"/>
    <dbReference type="OMA" id="FHINGHA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697820" evidence="7">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="79"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="461" mass="49244" checksum="C614A70128F074F3" modified="2012-09-05" version="1">MILLSIVTALLTAESALANTLSLPIYQSKRDDSEIDEWAHAQGIKQRAKYGHPLLLDRQSNLSERSIIALTNQNIDAAYYATIGVGQPQQAFQVILDTGSSALWLISQELAQAENGQFGSGYDTSASTSFKNKTDSFSVTYGSGKAYGYDASDDVQLGTYSLSSSPLAVVDQVTSTLIASPVSGIMGLAWSSLSQDVGTPFWQQLVQNNQISAENTMSFYLTRMRSNSQAQSLEPGGTFTLGEIDSSLYTGDISYHDIIGEDWWRVKMTGIKVNGETVFTPTMTIGAGVDSGTTLIGGPHDDIAKIWDAVEGAQEGSGSYAGYWFYPCDANPNIEIEIDGTTYAVNPEDLKFNRASSGTCQGAIFALTSGSTTGSDTSLEWVLGDTFMKNYYTVFRHTPASVGFAQLSDQAVASQTKVGSIPSPTVGEADSFGGSDARPNYSTTVILPITIALTTLIALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC99</accession>
    <name>I4YC99_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_68866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958288.1">
        <property type="nucleotide sequence ID" value="XM_006958226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC99"/>
    <dbReference type="STRING" id="671144.I4YC99"/>
    <dbReference type="GeneID" id="18475481"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68866"/>
    <dbReference type="eggNOG" id="KOG3148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_1"/>
    <dbReference type="InParanoid" id="I4YC99"/>
    <dbReference type="OMA" id="HVITQGI"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="289" mass="32378" checksum="A51B8722B90B19AA" modified="2012-09-05" version="1">MRLIIRDDKSSVGAFTATYIAKRINEFKPTEDHPNFVLGLPTGSSPLPVYHKLIELYVRDKVSFKDVITFNMDEYVGIPKSHPESYHSFMFDNFFSKVDIDPKNAHILNGEADNLVEECEKYEELIESVGGIDLFLGGIGEDGHIAFNEPGSSLASRTRMKTLAYDTIVANARFFDNDIQKVPRMALTVGIATVMSAREVIILITGKHKAPALAKSIEEGMNHMWTVSAIQQHPWAMVVADEDATLELRVGTVRYFKSIESVQAEQELKYGNAALRPKQRSIHASSPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN4</accession>
    <name>I4YCN4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_45428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958037.1">
        <property type="nucleotide sequence ID" value="XM_006957975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN4"/>
    <dbReference type="GeneID" id="18472364"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45428"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCN4"/>
    <dbReference type="OMA" id="NCLHSDK"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF51">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="472" mass="52187" checksum="9C38CD74AF5436BA" modified="2012-09-05" version="1">MSKELLESKEIEVVDVKTTDDFASQEKQVLRKIDLRILSLTALAYMLNHIDRTNLANAIIMNTDVPGSSMSEQLDLHGSRFGHIITAFYATYIIFEIPSNILLKKFGPSIHISRIVIGWGIVTTCSAAVQSYEGMIVNRIALAIAESGFFPGILYYFTFWYNDSERAFRLAFFVAFGSLSGAFSGLFASGCSYLNNLGHPALAGFRWLFLLEGIPTIILGICIYFWLPDYPETTKFLTEKEREIVLMRLGASVTKDDDKKLKMSSIWNVLKQWDFWFMAILWMLLGHGTAAFSFFAPTIINDLSEDYEGVIAQLLSIPPSVLACLLTIASGYFSDKMKNRPAFIIAGVISVSGGYLILAVDKNVLALRLLAVFLVALANVSIVPLAAYRLSIQGLKANTDSHAIGFASSASVAIANVSGITAPLILDSSMKFEYKCFVFLVLFITAGMQALFCLWWWGPGVETKKAREEGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU8</accession>
    <name>I4YCU8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phox-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958095.1">
        <property type="nucleotide sequence ID" value="XM_006958033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU8"/>
    <dbReference type="FunCoup" id="I4YCU8">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCU8"/>
    <dbReference type="GeneID" id="18473835"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60248"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014957_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCU8"/>
    <dbReference type="OMA" id="FICAHHN"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="282"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62370" checksum="9254225812BD7B9D" modified="2012-09-05" version="1">MKSLRRSLNKDKASNQSSPATSPKISVLQPPQLVIKALDSYKAQKSGELSFDAGVFYHVPDLGKGGDLYYEAHDPLKGTRGLVPRSLFEPLRKGGIGTRQSGVPSPVSPTGKSSTQYAVVQFDFIAERPDELSARAGEPIIVIAQSNHEWFVAKPIMRLGGPGLIPVAFVEIRDQKSNQALDTYTIVRSGIIPKVEDWKRQAADYKKASIPLGKFEFDQQPEDDKEKENHAPDGQPQQAEPVQQAQRTSNNSNNSNNSNISNNKTNSVQEPIKEEAPILHSTYIARIVEANVVSHYHENEVTWFQLDVTLLDTKSKTSSLVLFRLYEDFYDFQIRLLDAFPVEAGRRTSGDGTATPRILPYLPGPIEPQDLNESSIFRRRLELNQYINELSQLPERILSCDLMNEFLDVRPGDRDVTNLQPEVVQPPGESLHSSTSSISINGGLVESMSYLSVNNELPTSNSVDSSMSGLPKVASESTLSTASNSMMKVKVLHQPTGDLIALRISPSEIKLQALIEKIKERIGSDVQHLWSNEDNVADRKEISTDEQLQEWVNSGVKLSLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDD4</accession>
    <name>I4YDD4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_63725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957786.1">
        <property type="nucleotide sequence ID" value="XM_006957724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDD4"/>
    <dbReference type="STRING" id="671144.I4YDD4"/>
    <dbReference type="GeneID" id="18474863"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63725"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897730_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDD4"/>
    <dbReference type="OMA" id="HYVPKTF"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="299" mass="34998" checksum="281D138F9774FFC9" modified="2012-09-05" version="1">MYLTRRCIPLRQLPIYRQNISFYSTSQKNKLTEAQELDKHVLPPANPDASFPRRWWHKGKTLVVFYWRGIKQIWFNRDVVKQIQLKDGPLSHREFQLLTTHKKDIKKLVPFAVLFVLLEEIIPLIAYLAPQVLPSTVVLPSQKVSIRKAIENRRSNALEFYRHSYNQASRRQLLSSLSENDAPIEPQDVRILLRIFDLSTFGTASMRHNRLRNYLSHISEDDACILRQEVEKLKATSFLSEGELSDACSARGFLTLEIDNEKLTKILDEWLANYQKDNIYKPLHLILDQRNIDKSSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDN6</accession>
    <name>I4YDN6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957882.1">
        <property type="nucleotide sequence ID" value="XM_006957820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDN6"/>
    <dbReference type="GeneID" id="18473779"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60158"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDN6"/>
    <dbReference type="OMA" id="PDGLGCY"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697875" evidence="6">
        <location>
            <begin position="23"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="477" mass="51543" checksum="AC61324F4E702E46" modified="2012-09-05" version="1">MRNSANLTRTITLLFCFITALGAGTNYVFSSYGEQLARRLDLNHTQISIVASCGNAGVYFTAPAWGRFIDKLPLRIPLLISSCVLFIGYFGIYSFYAGLIHSQNPVVWVSLLSIIAGMGGSGSLLSALNATARSFNDNTRATASGIVLSGFGLSAFFYSFISHEAFQGSTDDFLLALAIGTSLSVLLGALFINVVPPESEKVADNEEGRPLFDENASLDEDILTSGSPLAILKSLDFWLMFIIIALLAGTGLMWINNVGAVVQALYAYHHPHYDPVTVAQAQTKQVSLLSLTNCAGRIIIGLISDYSHKKYKLNRAWWAAVISSAFVVSQLVAQSIKVPGQLGWATAMIGLSYGSLFAIGPVLTLEIWGLHAFSSNWGLMSLAPALAGPVLNLIFGGIYDSHAPTEDELEKYSKLENILNMPATASTCLEGRACYISSLHLTTMACVIALALSIYCAKRRSSRTPIFREETIDERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ5</accession>
    <name>I4YDQ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957900.1">
        <property type="nucleotide sequence ID" value="XM_006957838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ5"/>
    <dbReference type="GeneID" id="18475426"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68570"/>
    <dbReference type="HOGENOM" id="CLU_482499_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDQ5"/>
    <dbReference type="OMA" id="QDEHINH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="565" mass="65018" checksum="FE78322ADAF81579" modified="2012-09-05" version="1">MVITRKSRPELESDIRRVKSEITSLERQLQARETQSRFDDDLDDEEELEEILKKLAAAGESDALSALLQDNVFDSPDKDAITSTEGVDSNGSNTDSQNKSTTINKQQDIETQKQIHRFNAAIQLNQAFTGISIDQPTLLQEDQEVRDYRISGIIQSLGGIPFDTVVQFNTKTLRVTDLKINCPISGLHDAIKRIEDQHSLPLFYRTLHDYGGIVQHLNALMDELHTLYHKNVIYLNEFTIVFGDYTKRTLMLTCELKWDKPNNRLEPSFFVCARLSDKETASAKELDTIANMNINFQNMLVIGIPLKKAIEIALTAWLHMQQSQPLALPPSTAAELMLKPKDSRTNKEIPLKLKQIITKSNNDVMKRERMNEERKKKSALKKASRENAKRIKKLEKIMEIKERRRAERKEKHNTDREASKRVEGKFHKRKEAEKLQNEAEESRWSSSNVVRPEERNSEVSEQSSKRRRSSGSPGSISRSRSGSGSQNSPRSYIFRRSSVVDVSSEEDNGEEREHPGERTLEMRKARRMNERLQGRRAHETREIQRENDQASPSPRKRMTKTSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU0</accession>
    <name>I4YDU0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957934.1">
        <property type="nucleotide sequence ID" value="XM_006957872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU0"/>
    <dbReference type="FunCoup" id="I4YDU0">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDU0"/>
    <dbReference type="GeneID" id="18474876"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63873"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDU0"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="23289" checksum="7FC5C2C21F8F621A" modified="2012-09-05" version="1">MGITRDSLHKRSATGAKRAQFRKKRVHELGRQAANTRLGQKRVRTVRVRGGNLKYRALRLDSGNFAWGSEHCTRKTRLIGVVYNASNNELVRTNTLVKGAVIQIDAHPFRQWYEAHYGQPVTRKGRKEGEQQTEEVKKSRSVTAKQDERKKTGKIDPLLESQFAAGRLYAMINSRPGQSGRCDGVILEGKELEFYIRKLRAGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE00</accession>
    <name>I4YE00_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957987.1">
        <property type="nucleotide sequence ID" value="XM_006957925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE00"/>
    <dbReference type="STRING" id="671144.I4YE00"/>
    <dbReference type="GeneID" id="18475445"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68644"/>
    <dbReference type="eggNOG" id="ENOG502SAMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151409_2_1_1"/>
    <dbReference type="InParanoid" id="I4YE00"/>
    <dbReference type="OMA" id="HQPTLKH"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="12904" checksum="AF56198239CC59C1" modified="2012-09-05" version="1">MRPAGVLRKEKFALRLEHFMLKSQVISLYRKAIRGTRGIPFDEARYETLKWFRMDFERNRWESDPDRIKYQIQSMQREIKNSLPNYDLSMRPAEGFPRFWKQSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE27</accession>
    <name>I4YE27_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_32325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958014.1">
        <property type="nucleotide sequence ID" value="XM_006957952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE27"/>
    <dbReference type="FunCoup" id="I4YE27">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="GeneID" id="18471464"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32325"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_3_0_1"/>
    <dbReference type="InParanoid" id="I4YE27"/>
    <dbReference type="OMA" id="CSCKKEN"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="234"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="424"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="854"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="976" mass="110623" checksum="885C0F54B362F691" modified="2012-09-05" version="1">MNDNDEPNWARPHYEGPWLRTQIGLALLIGLPSFLLFCSLRTNSTVLFAPRTKLKGFSPHEAHDTSTFFGWILPTLRTSEYTVLQIVGLDAAVLLNFLKMGFWFFSVAAAITCPILVPINYNKYGTWEASDDSDESDNSTLSTFNTQEYLNYEEYPLYQESSSNPWDALKRHQGKWRKILDIFLFSNTDPYLGLQLLFTFFLSLLALRYVNKNYLRFVRQRQLFSLELVHAISARTVMIESIPSHLRDEKALSDYFDSINMKVETVSLVKGVKALDNLLTKRTKALLLLESAWSNYLGNPSQATFSQPSNNDLEISSINLTVLGKSRPTTRSGLFGLNGIKIDKLRMLERNFENLDRIVKTSRKSEYKNTHVAFVTFENASSAQIASQSSHYPEPGQLVTKPAPEPRDVVWKNVALSTKALLSKKLFVYGTVTTLLLTWAVPVTALYTLLSYSEISKYLPSLAKLLEKHPSLRALVQTSLPPLALVLFNATLPVFLHFLCVIQGHKARSHIEYSLMKKYFLALFITVILARMTTATISMVRELADAPLKIPDKLAQSLKSSTARHFFVSYIILQGFGILPLQLLQLNQVLPHMILRPFTKTPRDWAELNAPPELNYGTVYPQAILVFMVGLLYSIISPYILIAAAAYFGMAYLVYKYKLLFIFYKPWESSGQAWPITYARCCWGVVLFQTFMLGLFTLQGAFLYTSILLPLITATVFWAFHTERKFKGLSKFVNLSSLFEANRGTTPTEIVGLRYDQSVPRSQSNLNRRRYAMNDATLYVAPETDKTDYSQPPMRYWYYGVLNTGRRRYGHPALTGILPELWLPQRLAIAQKRGVGEGRVLTLRKRWSKVKKNAKRAFSNDERDQSTSRRMRSSVNSFADPQYPTNPWALASAEEAATRARTISYDGASGVIALPEGNLFCDDVEQDDNSASHDDDDSNSEVGIINDAVSDNEVDFIETNPRGDEEQQNSITFPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE85</accession>
    <name>I4YE85_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957539.1">
        <property type="nucleotide sequence ID" value="XM_006957477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE85"/>
    <dbReference type="FunCoup" id="I4YE85">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE85"/>
    <dbReference type="GeneID" id="18471403"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31991"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="I4YE85"/>
    <dbReference type="OMA" id="KPECTGQ"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="39080" checksum="52F2C110D8FA1F34" modified="2012-09-05" version="1">MPAVQSGTVLVTGGSGFIGAHVVRTLLIEGFHVKTTVRSTEKGEYLKKKLSDISGGGGQLEYDIVEDIEAPNAFDEAVKGVDAILHTASPFHFNSDDPNELIGPAVEGTLNCLRSAHKFNKDVKRIVVTSSVASVMTPRDTPTTFTEEDWNTHSPKEIEEKGKDASRLDFYMASKTLAERAAWKFVEEVKPSFDLATVEPPLVLGPCIHEIPTKEKLNTSIARFYELFSGVLKDATPEKLVEPMSNIVDVRDVANTHLLALTFPSASGQRFITASDRGMVTNQDFVDALHSRLGDNEAVKKNVPIGEPNAGKKINRHRFSNDKAKNTLKQTFFSQEQTAVDTFLSLQEYEKQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE96</accession>
    <name>I4YE96_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_16946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957465.1">
        <property type="nucleotide sequence ID" value="XM_006957403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE96"/>
    <dbReference type="FunCoup" id="I4YE96">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="GeneID" id="18470710"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16946"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_3_0_1"/>
    <dbReference type="InParanoid" id="I4YE96"/>
    <dbReference type="OMA" id="LPACTCK"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="99"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="512" mass="56721" checksum="E9D96A585107E83C" modified="2012-09-05" version="1">MDDDGLHTFDVKSKAPESSGFYPFSGRGWLNFGMIGVLIGALLMLFAGYPILSFFRDQGQTTEGAYNLGGINATGQIPVLPGVRGLVDDDTPEDVKHRVGYDGKNYKLVFSDEFEQEGRTFFPGEDPFFEAVNIWYWPTGDMEWYSPEQVMTRDGALEITMENTDVGDLHYKSGMVQSWNKFCFSGGIIEFAIQLPGRGDVSGFWPGAWTMGNLGRPGYGASTEGTWPYSYDSCDVGTMPNQTNKGGTGPIGALNSNEGNALSVLPGQKLSSCTCKGEDHPGPHHSVGRGAPEIDALEAQTDFVRKGGAASQSGQFAPFDYGYDWRDGEDYTPIYDRTNTELNSYKGGVYQEAVSGVTFLGNDAYELTKQEFMKFGFEYSADPKTRDTNSITWFVDDDRTWTMNAAAVGPDERVQIGQRLVSEEPMSIIMNFGMADGFSAVELDKLNFPATMRVDYVRIYQTEDHINVGCNPPSRPTTDYINDHLDAYMNANVTQWEKLGYSWPKSSFKDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEA5</accession>
    <name>I4YEA5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957554.1">
        <property type="nucleotide sequence ID" value="XM_006957492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEA5"/>
    <dbReference type="GeneID" id="18473675"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60000"/>
    <dbReference type="HOGENOM" id="CLU_1817299_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEA5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="16908" checksum="4ABF491DA2F3E4F3" modified="2012-09-05" version="1">MPYWFAYVAIENNSLIVYAKHQQNIQAVWLIPFTSLKGVGTSSFNDSSYEDTVMRLHIKLDTPVAEYINETNAKRPLRVSHDILAFRIKSHKYFNFRAFDNFVNDILDYAESEHLNIYKTTHKQFYEDLDWRYKNRSNITVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED5</accession>
    <name>I4YED5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_32032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957582.1">
        <property type="nucleotide sequence ID" value="XM_006957520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED5"/>
    <dbReference type="GeneID" id="18471411"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32032"/>
    <dbReference type="HOGENOM" id="CLU_2607861_0_0_1"/>
    <dbReference type="InParanoid" id="I4YED5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="79" mass="8898" checksum="16D0806BAE799788" modified="2012-09-05" version="1">MSAYSVDHIRVKLMEDELMRRPNAKGVCKKQDTKAPGLFHSQPISHNTFPSLSIVANILLLVILPCHMRSNLDECHVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW6</accession>
    <name>I4YEW6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_44096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957181.1">
        <property type="nucleotide sequence ID" value="XM_006957119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW6"/>
    <dbReference type="STRING" id="671144.I4YEW6"/>
    <dbReference type="GeneID" id="18472319"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44096"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEW6"/>
    <dbReference type="OMA" id="DFFMDRF"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="38885" checksum="8049D59DD844EAAA" modified="2012-09-05" version="1">MPQQLNFGVLGLGRMGIRHALNVVKEPRANLLAVAARSKGTLDSAREVLPASVEFHNNEDEVINHPEVQAILVSTDTSQHARLSLKVIEAGKHLLVEKPISVDLEDSKSVVDAANKHKELKVMVAFVRRFDESYREAYNRIKDGELGDVYYVHGATNDMYDPEAAKFFKEFSKANGSILVDCGVHDADLIRWYIGNEKVKKVTATGYNALIHDLAESQDADNAVGNIQFESGKMATLYLSRTARHGHSCSLNIIGGEGSFVINSDDAQNRLRLFNQTGLNVKSHKTYYDRFKEAFANELSEFTEAILENKELPITVDDAHEAAKMVVGLQMAFRSGKQVFFDDAGYPIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEY2</accession>
    <name>I4YEY2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_36506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957196.1">
        <property type="nucleotide sequence ID" value="XM_006957134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEY2"/>
    <dbReference type="FunCoup" id="I4YEY2">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEY2"/>
    <dbReference type="GeneID" id="18471966"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36506"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_2_1"/>
    <dbReference type="InParanoid" id="I4YEY2"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="20004" checksum="1B0CB2DD4D08FEB1" modified="2012-09-05" version="1" fragment="single">MVGSHTIGNTSLAFSRAWHSVDAKDRVLGRLAGRIALTLMGKHKPIYDPAADCGDYVVVKNATKVLTTGDKANQIVYRNHTTYPGGLKEISFNRLKATKPDEIIRKAVSGMLPKNSTRKHLLDRLLIFNDETLPDSINGNITKDYLNGDKVLPQADKGWKAIGGRRGPEGGPRWHKSSFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF54</accession>
    <name>I4YF54_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endonuclease III homolog</fullName>
            <ecNumber evidence="13">3.2.2.-</ecNumber>
            <ecNumber evidence="13">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="13">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NTH1</name>
        <name evidence="16" type="ORF">WALSEDRAFT_59847</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="13"/>
    <dbReference type="EC" id="4.2.99.18" evidence="13"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957265.1">
        <property type="nucleotide sequence ID" value="XM_006957203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF54"/>
    <dbReference type="FunCoup" id="I4YF54">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF54"/>
    <dbReference type="GeneID" id="18473585"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59847"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_2_1"/>
    <dbReference type="InParanoid" id="I4YF54"/>
    <dbReference type="OMA" id="RGKRCDL"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="114"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="331" mass="37536" checksum="1669837DF3AFC158" modified="2012-09-05" version="1">MSSSPSPPPSKTPRLRYKPSRTDTRLTMVEIDDKDTKRAPLKRSASSFTKQKRIQRELDVPHEAPENWETVYDLIKEMRSTQLAPVDTLGCERAPTENLDARTKRYQILVSLMLSSQTKDAVTSDAVNNLREQLEGGLTLESVLAATDKQIQDAIAKVGFWRRKTEYLKKAAVMLRDNFEGDVPKDIDELCSLPGVGPKMGFLALQAAWNQNDGIGVDVHVHRITNRLGWHQPPTKQPEQTRLNLESWLPKELHRDVNKLLVGFGQTICLPVGPKCEDCKLSAEDLCPSARKFEGKKNKRRKTTELKREETEEERGEQLAKLEIVLEGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF66</accession>
    <name>I4YF66_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_36625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957276.1">
        <property type="nucleotide sequence ID" value="XM_006957214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF66"/>
    <dbReference type="FunCoup" id="I4YF66">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF66"/>
    <dbReference type="GeneID" id="18471969"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36625"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF66"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="260" mass="29785" checksum="5DDF847D19904F0A" modified="2012-09-05" version="1">MPQNEYIEEHQRRYGKRLDHDEKLRKKEARSVHQNSKLARQTHGLKAKLMHKQKHAEKVQMKKTMKNHSERNVKKDEEKPDDSAALPTYLMDRNEQRDAKSISSAIKQKRKDKAARFSVPLPKVRGIAEEEVFKVIKTGSKKQKSWKRMITKPTFVGENFTRKPPKLERFIRPSGLRMKKANVTHPELKTTFQLPIIGVKKNPQSPLYSQLGVLTKGTVLEVNVSELGMVTTGGKVVWGKYAQITNNPENDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFA0</accession>
    <name>I4YFA0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957308.1">
        <property type="nucleotide sequence ID" value="XM_006957246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFA0"/>
    <dbReference type="STRING" id="671144.I4YFA0"/>
    <dbReference type="GeneID" id="18471378"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31846"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652474_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFA0"/>
    <dbReference type="OMA" id="HIATRRE"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697920" evidence="3">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="418" mass="47607" checksum="615EBC1840E9211D" modified="2012-09-05" version="1">MKFSALSVTALVAVTNASPLSFRGLFGGDDKHKHDEALYLLGHSEKTKDYKVFSEADNVPSDVILDHYPLPNCKDGVKERKNWAHLSYDERKNFVDAFKCLRSKESWNLDNYMMSDRLADFIRIHQWPGADIHWVASFLPWHRGFTLIYEQQLQECGLEGTLPYWAWENDYADVTQSAVWDGDMDAGLGSFGHTDESLPLNASLITDGAIADYEITYPWPHKIGRRLRSNFAPNTPNIAGEYFERGRSPEWIKYYQSFDNYLNFSTLLEGYDPLDARADWPSSHGSAHLLTGGDMATGDVNNTSPADVLFFLHHANVDRHWMAWQLQDPENRLYQYEGNTQYDFQTGIRGGVKATLDQNLYYGDVPGQQGIAIKHLMDLENSWCTTYTDLDKVVPKFWEARTDAFSGPGQLDEAAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ9</accession>
    <name>I4YFJ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957399.1">
        <property type="nucleotide sequence ID" value="XM_006957337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ9"/>
    <dbReference type="GeneID" id="18475358"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68171"/>
    <dbReference type="HOGENOM" id="CLU_1273136_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFJ9"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="25106" checksum="7B263E5F0C8BFB51" modified="2012-09-05" version="1">MSSCIVLAELKQSHGYISYGHRFKAAARSWTTRLQLTQREYGENVKVRKDILQTKAFENAQRDLNDILYELRQSIEISAQLEEQAGDNFDIDVPRANSDYNRHMQTTLAKLKDEQPDTPYQARFKYAASLWQDKKKVHKKAVKDARPLYTNEAIANKPTDEDLLLENQQPSSSTHEGRLPMSYFTNDILNDDIFNGIADNISIPTVNYFDTNFNEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFM7</accession>
    <name>I4YFM7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Krr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_27997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957426.1">
        <property type="nucleotide sequence ID" value="XM_006957364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFM7"/>
    <dbReference type="FunCoup" id="I4YFM7">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFM7"/>
    <dbReference type="GeneID" id="18471019"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27997"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFM7"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="531"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="681" mass="78637" checksum="5CE750FA633A27CD" modified="2012-09-05" version="1">MNLDLDGGDELKINQDFADRFTHNKQRAELHRLQEKYGDNFEDDDESDDSDMSSEDEDGELLTADVDAALLKTLSLLKSKDPSIYSDKKVFEEEQKKLKDKAAKLNVKRTKSTGKPLTLADLEREKLLKGELSDEEDNDAEDDNLQPFTHVQEQRNLKKEVTSAFHGNDDDDEDDFLKPKTVEDDDNYQTRGSYRKFLLESVGEDEIRKALGLDDQRISSTKEEIESASKPSEPIEKESKKSSKTTAKPSKAEQKAKDDKFLMDYILNQGWMPGSSASVPRDFTVSDAKAAEEGTSVNLSGANANHEIIEDDEEFDEHADEWEHKYNFRFEEPQGDDVKTHSRQLDSTVRRPDNKRKEQRAAKKERKEKEKQQREEELKRLKSLKKDELKHKLAVLGEDASKFENLDLDAEFDPDAHDKAMREAYENDDDYDDEFGDEKPTWDDDIDIGDIVDAEDQDGDDINMDADFDQDDGRITMSKRERKKAKKKAKAEAKNASKEDYDGDDIDMDADHMQGQEEEPIPATAEERQAALEQWLDEYYKLDYEDTIGDLKTRFKYTNVVPDNYGLTTDEILRAEDKDLTRLMRVKRMAPYRKDHIANSGKGKYANGMMSRVREFKHKVNNERAGWGEDPKEFQKRKQASGNKRQRDDTQSEPPAKKKKIGKRERQKRQKKRELEESEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN2</accession>
    <name>I4YFN2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SCO1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_16755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957169.1">
        <property type="nucleotide sequence ID" value="XM_006957107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFN2"/>
    <dbReference type="FunCoup" id="I4YFN2">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFN2"/>
    <dbReference type="GeneID" id="18470704"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16755"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_3_1"/>
    <dbReference type="InParanoid" id="I4YFN2"/>
    <dbReference type="OMA" id="MLYFRVE"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="24790" checksum="FF92B17EB98440CB" modified="2012-09-05" version="1" fragment="single">PFNWVSASLFVATGVGLYYYFNKAKAEVEESKKRKISESEKLGKPKIGGPFSLIDAKTENSFTHENLLGRFSLVYFGFTNCPDICPDELDKMGTVVDRVVDAKLGQIVQPVFISCDPARDTTAQTRKYLEGEFLIRFHPRMVGLTGPWENVRAACKVYRVYFSTPPNISPNEDYLVDHSIFMYLMDPNGEFVEAFGKNTTAEQMADKVLSYTESYVQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS0</accession>
    <name>I4YFS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956865.1">
        <property type="nucleotide sequence ID" value="XM_006956803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS0"/>
    <dbReference type="STRING" id="671144.I4YFS0"/>
    <dbReference type="GeneID" id="18473464"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59627"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFS0"/>
    <dbReference type="OMA" id="SHITTPW"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="369" mass="40747" checksum="6D080F39A9C2332A" modified="2012-09-05" version="1">MNRPTKCNPSITCISDLEKASYCKLNKTVAEYYNEGSMDLITLRDNTAVYDRYKLRPRVLRNLTNLDTSTMCLGSRVSFPLGISPTAMQGLAHPGRELATSRAASKMGVNMCLSTYTNTSSEDVIAQSNGGNSYAQQLSIMKDNSINMEIIKGAEKAGYKAIFLTIDCPYLGRRLNEYRNQFKLPEHLTLPNLPVEDGNMVTRDERLEYDDQLDWEGIARFKNSTHCEIWLKGILTAEDAMLAVEAGVDGIIVSNHGARQLDGSCSTLDALPEVVGAVGGRIPVHLDGGIRRGTDIFKAIALGAQHVWIGRPVLWGLAYNGQEGVELALQLLYDEFRLCQALCGCLTINDITSKHLARLHADGRYRPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFT5</accession>
    <name>I4YFT5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956879.1">
        <property type="nucleotide sequence ID" value="XM_006956817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFT5"/>
    <dbReference type="FunCoup" id="I4YFT5">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFT5"/>
    <dbReference type="GeneID" id="18473471"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59639"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="I4YFT5"/>
    <dbReference type="OMA" id="HMGTETC"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="11"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="119"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36051" checksum="78A5E63FE8188828" modified="2012-09-05" version="1">MSAKILISGTIVWAHKEIEQLKQFGEVVQLTSTSRQQFYEELETKYSGIVAIYRHNDSASKIGFFDKELIDKLPSTVKFICHNGAGYDQIDVDAATARGIQVSHTPAAVDDATATTAMFLILSSLRQYWKAEVNARKGVFKQGLKPASDPEGKTIGIIGMGGIGGALAKRALGFDMKIKYHNRREIQPPPSFPCEYVSTLDELLATSDVISLNLPLNEKTANSFGREQFSKMKDGAVLINTARGGVVEQEAFIDALKSGKLSSAGLDVYPDEPNIDQRLIDMPNISLLPHMGTETRETQHKMEVLVIDNIKSAISSGKLLNQVHEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU6</accession>
    <name>I4YFU6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_36045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956890.1">
        <property type="nucleotide sequence ID" value="XM_006956828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU6"/>
    <dbReference type="STRING" id="671144.I4YFU6"/>
    <dbReference type="GeneID" id="18471940"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36045"/>
    <dbReference type="eggNOG" id="ENOG502S7ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074438_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFU6"/>
    <dbReference type="OMA" id="ELAIWAN"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="259" mass="29378" checksum="219AA01394C98C2C" modified="2012-09-05" version="1">MPSSLPPLNWLVSPPTSLDTSPNNPEITQTSHEELSLPIQPDELTKQLDLWANVKFDFDSPENAAGGQLASLEEDYSKAFGFEDAKSYSNKRQKYDFEAALAGIQSAAPPGTIAQQIDPLSNLFKETPAPVINSKELEALDDEEDNEDKIIRRRRFKKLPMPPVQQRDGETYEQAKKRTEKEHKDAETAAKRELEEDKRRRNTAASARFRVKKKAREAALEQTANEYKGRVEQLEKEVGDLKRENGWLRGLIINSNNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG12</accession>
    <name>I4YG12_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_56582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956952.1">
        <property type="nucleotide sequence ID" value="XM_006956890.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YG12">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG12"/>
    <dbReference type="GeneID" id="18472825"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56582"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG12"/>
    <dbReference type="OMA" id="SHFNDYW"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="350"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1660" mass="189221" checksum="571FA094F6EFB0CD" modified="2012-09-05" version="1">MAETPPSASTPTTPTKSSALANWLPRSRAPTISNEDQTAAEKDKTITLVSDPVYRKYAQSVDRSLNAFLDVQEWADFIAFLAKLLKSIQSFTQYNEIPHKLIVSKRLSQCLNPALPTGVHQKALEIYDKIFIIIGFEGLQRDLQMWSAGLFPFFQYAAMSVRPAVLELYKSHYFPLRANLRSIMKSITLSLLPGLEEETGDFFDEVLSMLDYLSNTVSPDYFLQNISLILLTSPASRIPALNYLIRKMPTLNTDEDVIFHLNSDANILVRGISSSLIDTDMFVRRSALDLLNSALSINGLILQKYSKKDFQVDLSRNACNVVLRRDISLTRRLYSWLLGSSDVKEVQSEHFEKFSLPLIRIWMLSDMNSTKSFDSRPYKIFISLLDKWEIGNNLTENVITEIIRSLKYHLENENDSADVKIITSMVLETVDIRLLWKAMNEQITVEYGGQSDLFESIDLTSMIIDNISPKDEEHARLHFPVQLVNSLNLAYTDQQSENSKLSLLEHTLYLTQKLISHIPDDVFGKNASLVKDGHHYTSDWESIAKAYYTSNEHIPQVDTPDTLYEASFRLLILITSSWGQELSDTSAVKVSYDTLYKLIHLRKSDKILSGKCRELISGWFEVAMKFISISKDFETLKSLIECILIIREAGLEEDEMYLKWMNREAHETLLKSLLNHINQENPTNHSSVVALMQDIEKTTSRKHISSLLSSRLYDNNLSARMEAVEQFGIIYNLVESSDIPVLDVTVPVSKFFSYQTFGNADEMQVNAVWLKNNFKSSKQLASTYIFNVSKVDQYMKLVKRSDVHGSEVECYEYFQNFDQEIVIYSLQQLLKLSEHSGTAFWRQLNTEKQDVLLFEQLLKLLKTEPSEIIKETLQPGSKDVQMASMRLLIELISNCSMASDKYMAAAITISNYLNYHLHFNNLDVQPKAIELLTATLEHFDFNDLDDVKDLGSSVIKLLHGAISTASSQMSLRHWLDMTVLLVEDYPSLIRNHKLEAGYIVCDKLGNMLDTLDLSENIPSQNDLSSILAALDVILTFNLDDLYSSSSTSHDITIINQTMTLVRSTFRRYTKLYFALQDRKNNIYNMLIAQCQQNIFNLFDKRPSEMVDLAVEHHHQENNVSALLELLKLFSDKPRLLVHIFCRNVGLKTFAGHEKPRSMWLSDAVTHLQLFQSLETYLDTLDVKDALQSWVALQPFARESIMSTLTAQRKACIYPTLRCLYKFGVQVFVAQSSLIIEKRVHQDYQDILQRFVESCILLSSGTSDTGTWALRKALAGLDVTNVTGNSDFADNTTSKADEVDDNSFNENMIEIHTFIAKELLVNISKLITTTEKLQSIANNVSYYIVAPVLKSRSKNFNSTSPLIVDMLTEMTKLPHCSRSWRGLVSDVFYDNKFFTTSASSQWKYLVNALMSTDKDKFADLVSRVSSAPSTNIFANREYESLTRALNLRRLSFAIYAGDPGSYMSQLTIVKEKLVEVVRNNAITPISQAEVYLCLRVLLIRFKSDNLTMFWPIVITELLRLFEIIKSAQTSEHSDLLSLLLSACKFLDTLLVLQNEDFQVYQSLFITDTVDASAIGDHQGGIIDQISQLFGNQEKFDGQFSPQLENTQRQPLLLNVKRIESVQDLQPFFSCVSHVTFNNVIDKQEVDWKLLDRTIGGDFFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD5</accession>
    <name>I4YGD5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_63049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957064.1">
        <property type="nucleotide sequence ID" value="XM_006957002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD5"/>
    <dbReference type="STRING" id="671144.I4YGD5"/>
    <dbReference type="GeneID" id="18474807"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63049"/>
    <dbReference type="HOGENOM" id="CLU_130569_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGD5"/>
    <dbReference type="OMA" id="MESEELC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="85" mass="10123" checksum="3608768B30A9C493" modified="2012-09-05" version="1">MENKEKERQIKIREGVVKRLTKELEMYKQEVVDGEETMNKISLDDENGQWKKNNQSKLIEESKKLVIDTEQRLTKAIDELEKIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH3</accession>
    <name>I4YGH3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957098.1">
        <property type="nucleotide sequence ID" value="XM_006957036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH3"/>
    <dbReference type="FunCoup" id="I4YGH3">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGH3"/>
    <dbReference type="GeneID" id="18473537"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59755"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="InParanoid" id="I4YGH3"/>
    <dbReference type="OMA" id="TRGESMF"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="549"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="780" mass="86177" checksum="4D6C9AF4C4F83E17" modified="2012-09-05" version="1">MSSKFESFLKKLGIEKPEGQEDRVTRGESIASNYADPFVEPDPTVTEWFKDKLPDRHELGQYCLDLVPFTRWIHRYNVQWLIGDLIAGITVGAVVVPQGMAYAGLANLAPEFGLYSSFVGVIIYWFFATSKDITIGPVAVMSTLVGEILEEVSPKFPDIPDYQIAGSLAIITGAIVCFMGLIRVGWIVDFIPLPAIAAFMTGSSINIIAGQVPTLLGNKKATNTDGATYEVIISTLKHLPESNLNAAMGVSALFLLYFLRETFNYCAKKWPRYQKVWFFANTLRTVFVILLYTLISWLVNMHHRGVDGQPPPKFSLIGTVPRGFQNMNVPVVKAEVIKAYANHLPGAVIVLLIEHIAISKSFGRVNNYTINPSQELIAIGVSNLIGPFFGAYPATGSFSRTAIKSKAGVRTPFAGVITGVIILLAIYALTAVFFYISKAALAAVIIHAVGDLVLPISQLYAFWKVSPLDAIIFVGGVIIIIFTTIEIGIYVTVCVSAAVLLFRIAKAHGEFLGRIKVQTVDGQDQRNIWLPENHEDGSNPLLSVQSPYPGVFVYRFTESFIYANANHYTDEVVEYIKKATRKTEINIFSKPGDRPWNDPGPRKIDPDAVAEDGRPTLKAIIFDLSSVTHVDVTSTQVLVDVKNQLDRWAHPDKVMWHFAGIRDRWIKRALAAIKMHETTTVNAKPLFSVAEVGHFSSANDATVNSKPEDIEAGLNAQREQEQAEAVRRDSYARYLPVLGVDRSFHPDIDSAVRAVIETLEQDQIDQEEQKTQSDVISPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH4</accession>
    <name>I4YGH4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957099.1">
        <property type="nucleotide sequence ID" value="XM_006957037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH4"/>
    <dbReference type="GeneID" id="18475319"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67933"/>
    <dbReference type="HOGENOM" id="CLU_1385135_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGH4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="197" mass="22159" checksum="C446409E20003685" modified="2012-09-05" version="1">MAVYACRPCQISHSSCDNYRPCHNCVRKGIQDNCITIEHRRRGRPGKHEREQQKPSLPYHRTIQPLSANVMPEYITMVVTPDLQRTIQVSPNSTFADASTLPSLHDITSVYHAPRLASLQAKLSLGEMCPRENVSIVDRYGRHFASTLSLRWLIKNETVSAEMRIVEEITPVPTLPFTPSSGESSRSRTSISALCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGN4</accession>
    <name>I4YGN4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956527.1">
        <property type="nucleotide sequence ID" value="XM_006956465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGN4"/>
    <dbReference type="FunCoup" id="I4YGN4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGN4"/>
    <dbReference type="GeneID" id="18471278"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31304"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="I4YGN4"/>
    <dbReference type="OMA" id="KGLHRDT"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31527" checksum="71A032BCD511F6D2" modified="2012-09-05" version="1">MSASQVFYITGTSSGFGRELALILSQRGHKVIATARTISKIEDLGKVDNIKIQQLDVTDSFDILQKKVEEAISFFGTVDVLVNNAGYSQTGCFEELTDGEIRKQYDTNVFGTVNLTRVFLPYFRSTEKESIICTITSAGGLVSFPTSAAYTSTKFALEGFFEGLDGELKASNLPIRVLIIEPGGYKTNFIGNIIKSENQIDVYNPIKEQIHQLFTEYDTTTGGNALIGSKLIADALLKQGFAAGKDIPLRLPIGSDCINWSVEKFKKTVDIFEEWRPFAAESDPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGR7</accession>
    <name>I4YGR7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_27302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956555.1">
        <property type="nucleotide sequence ID" value="XM_006956493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGR7"/>
    <dbReference type="FunCoup" id="I4YGR7">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGR7"/>
    <dbReference type="GeneID" id="18470986"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27302"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="InParanoid" id="I4YGR7"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="15418" checksum="35BAA5876A88C2D8" modified="2012-09-05" version="1">MSNGQVQTFGKKKTATAVATCVSGKGLIRVNGSPIQLVQPEILRYKVYEPVLVVGESKFAPVDIRVRVSGGGVTSQIYAIRQAISKALVAFYAKNFDAASALDLKKTLVSYDRTLLIADPRRCEPKKFGGPGARARVQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGS8</accession>
    <name>I4YGS8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956566.1">
        <property type="nucleotide sequence ID" value="XM_006956504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGS8"/>
    <dbReference type="FunCoup" id="I4YGS8">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGS8"/>
    <dbReference type="GeneID" id="18473373"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59474"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGS8"/>
    <dbReference type="OMA" id="KHLRHIF"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34877" checksum="338A63E3F8010BEE" modified="2012-09-05" version="1">MYRAIRKLGIPDSNIILMLPDDIACNTRNKYPGSVYAHKDHRLDLYGERVEVDYRGYEVTVENFLRVLTGRHTEDTPASRRLLSDENSNVLLYLTGHGGDEFLKFQDTEELNSQDIADAIEHMRVKKRYNKMLFISDTCQAATLANRLYSPDVLAIGSSLKGQNSYSHHTDREIGVGVIEGFTHFTLNALSDIDSNSNSTLADFIDSFDKKQIKSTPGVRDDLFGDLSETLLTDFFAGNIKVDVLPPDVKHELVVGESVDKIDDIENDKVQEDKTTVKETKEMHILDNLNYSHIFALLFILSLIIHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGU5</accession>
    <name>I4YGU5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_56355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956581.1">
        <property type="nucleotide sequence ID" value="XM_006956519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18472801"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56355"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235129_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGU5"/>
    <dbReference type="OMA" id="DATVYKY"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <begin position="860"/>
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            <begin position="1049"/>
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            <begin position="1187"/>
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            <begin position="277"/>
            <end position="304"/>
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            <begin position="146"/>
            <end position="158"/>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00015110"/>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000259" key="12">
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    <evidence type="ECO:0000259" key="13">
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        <source>
            <dbReference type="EMBL" id="EIM23187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
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    <sequence length="1553" mass="173452" checksum="2414D173FE7C92CA" modified="2012-09-05" version="1">MMTQSLLPNATQFNNNLQQSFQQAPAPPKIPWKLSRDEKRNYDQIFRAWDVHSTGFISGEQAKDVFGQSGLPSDDLMMIWNLADIENRGKLNLAEFHVAMALVYRRLNGNPIPDELPDELVPPSSKDLNMQVDILKDILKNDNHQRITTPQIPSSRSDASIYKHDDDQAASSTYKSSSRHLDRRNVRYSDNSPVSDLEDMKRELANTSAKLDKATTLSGNRTEEDDQLERDLDDLKYSIRRVQDDLDFVSSGRPSREKDQERRQLERELLYLMHDRLPEVEKRMQRAEARKKDTEREALRYRDYRNDRYRRYRDDDDDPYYRRSSPDYPPSRRDRDYDDRSRGGYESPPARGYMRGTYDDRPPPEPIHPRVADKTPPPPPPVAQPKEVDTSAKSPPPAPSHSGSTNLRGMSTEARKNYIQNEAQRRVQERLKALGVSTGDETQGGDETVAERLEREKKEAAERAQKEDEERSRKEQERVRRVEEEKAARNPPPAQPVQAQATGKKAPPPPPPSRRQAPPTPVSRTPSQQPPAVPPAQPPVQPPAQAQHDPEEEMLEQRRRAKEARMKALEDEERQLAEAEKKFKERQARLQAEDEARQAAPVPAAPPVPAPAPATPASIPTPASVPRAVPSPRPSIPTPAAAPPAPSPPVPVAPPAPPAPVVPSPPAPQPVSSPAAPPIPTAPAPPPTVAASAPAPAPQELSQGQATVQEKESTNPFVRMQQQKERGELPPSSTLQAQPEASSIPSPIAPVPTVPKSSHLTNDSDDDWGEDAQEKSDEEDSSDDEFSSRAKRDNLAKVLFGGMVGGSSGTSTPNAGSETPASPSSAPQAPPAPAPPAPAAPAAPSAPVPKAPSAPSQPADRGSLLSQIRGGKSLKKSHTNDKSKPASGGGVIGDDAPPAHISDAPREHEIAREPEPEPEPEPIVEDPSKKDNRQSVDWISNLATDGGVAQQTPKLDQVTEEHDDDYVKVPAISVDPTDTLSEEFDLHSVIKCRSLYAYAPQRDEDLGFTENIIIEANPCRDPESPWWYGKMMASGQSGYLPKAYVKELETPVKAKALYEYTANSQDEFSLYEGQIVDVVDKSENDWWKISTNDGLIGNIPATYVELLNVAPVKQERRRRAAPDIPRPKSTIESPTRSEERSQNQEIKTGRKRSQSDALERTRARTTSSSKLGEFFGRFRTYSNASSTAGADLTADDNSSGSAIVVTGPISRPVSRPMSQQSSHSANWSSMINQSVLDTFTTDERNRQESIFELIKTESIYVKDLTAIVQVYLADLIKDVDDMTIEMIFSNIEDILLLNATFLSDLELRQNEQRMYISHIGDLLDKHLSNLEIYKQYCGNQHKSIKMLQNLQNNNYMISQRIENMRNNPTCRNLELSTHLLSPMQRITRYPLLLKQILKYTQGDTEEYTLIEKSEERIENLLLEINEDVRFQESHTRLQEIAHSLNVNQKFDLSNTRTRSRLLIKEGDFPKLKSHKIIRVVLCNDILLLINVQENTLYKLPIPLNEVTMTSHPRREDVLQIDFAYPRGGEVLNLKCQDRNSWINIINSTKKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGU9</accession>
    <name>I4YGU9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/M-specific cyclin NimE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956585.1">
        <property type="nucleotide sequence ID" value="XM_006956523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGU9"/>
    <dbReference type="FunCoup" id="I4YGU9">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGU9"/>
    <dbReference type="GeneID" id="18473380"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59482"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_10_1_1"/>
    <dbReference type="InParanoid" id="I4YGU9"/>
    <dbReference type="OMA" id="WRMRTIL"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="269"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="362"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="366"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="507" mass="57714" checksum="68EE5EF0FADFAD66" modified="2012-09-05" version="1">MSTLPVRRTTRSRNVDENSTSTTNNLNRKVSTSTISTKAPTTKKTTTVENSTVLDGKRKRNALGDLTRTHANNDKSSTITTRDVNGKLVNKKPSTGLGKVDPTTTKRTTRSASNSSKPVDEGVPIDPTKRRVAKPATTQVKSKVGRPTTKKPTNVKQSQVEDEMDYVDEPDVKRQRTSSPGDELLLEAQRFEADEERRRLAKAKQNLPAADEGWEDLDAEDEGDPLMVSEYVVEIFEYMKVLEQQTMPNPNYMDNQKELRWRMRGVLVDWLIEIHHKFRLLPETLFLAINIVDRFLSLRIVSIIKLQLVGLTAMLIAAKYEEVMCPTVANVVYMSDGGYEESELLKAEQYVLQILSWDLSYPNPIHFLRRVSKADDYDIETRTLAKYFMEISCVEEKLLRFPPSQIAAAATYLSRMCLDRGEWSANLVHYSGYSVLELLPCAQVMLDYVKSKDIKHDAFYRKYASKKFLKASTFVREWALGLYGPDGQANLEAEYRQECEDQGIQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH90</accession>
    <name>I4YH90_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_27430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956717.1">
        <property type="nucleotide sequence ID" value="XM_006956655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH90"/>
    <dbReference type="FunCoup" id="I4YH90">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="18470993"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27430"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005652_1_0_1"/>
    <dbReference type="InParanoid" id="I4YH90"/>
    <dbReference type="OMA" id="VSERPHN"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="318"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="631"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="724"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="760"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1070"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119098" checksum="5FCA4A91271185E6" modified="2012-09-05" version="1">MANNNIHYLSKRALQIQQEEGIPSNSPTRPSVRRARAGTLPSNLATVAPLPTLNLSQAGLSSAAIESLDYNSQRPGLRHSHSSALQPEKSPRLRSGSLTLPPSSPSVQRLADPFGSRFFYSRSNSQVGAVGEEVSRPSDLPSEDACLRTLDYLGLDDPPSSPSSPKPTLSIPPQGFAKSISLNSPTRSRAYTLSTSKAADPFKSSFTAPADHLHPSSANLINSNPLADFQAFPTQPQPQDPLINGLSSSQSSRPRAISMGILDEPDVMRAPARSGVPFPDAQPHPLQQSFNSYDLELSQLDDPYSTLNQVQSQQVPTRSLWIGGLDSRTTAQELMHVFAPYGAIESLRLLTDKECGFVNFVEKSDALRARDDVMHRLGGRIPTSSANGGSASTTPVRIGFGKIDSPQNPPSTSSLLNSSGGNLPVQVPANMSNQINFDGTTEQPTRALWLGSIPSTTTPATLLALFGPFGPIESARVLTHKNCGFVNFERLDDAVRARKSLNGRELLGPEIGAVRVGFAKVPVKTTGIDDSANTIIFPSSTTAPNGGHPQALAHSLVGVQGVSDISIEQQLASGQTENYRSNLMINLLQNGAKEGVVNSISPKLEQVNPEERPSVNDQQMIMSILSAGHESRDEDIRSVSELRPAATYYTSIPPVLPATNGIDNQPIRKFDSSKLRELRKKLENQDEDKRRASTDEELYDDDNSQFPFSDDPEILATKPMSEGGLIDNIVDLASDYIGNTIIQKLFEICSFESKMRMLNELAPHLAMIGCHKNGTWAAQKIIDCATTSQEVELIVQHLRPFTPPLLLDQFGNYVVQCCLKFGAPANEFIFDAMCDRIWDVAQGRFGARSMRAILESSHITLRQQKRLAISIILNSIPLATNPNGALLLTWLLDTSNLTGRYGLLAPRFTPHASHLITHKLASLTVLRLVNQKSDREATDILLQAIFESTNDNVLFDALMDPAQGVSVITKLIVSPTIDEVKRQQYMESIKRVLTNGNVKINNPAAYRRLLDEINLPMNKLNIIQPLNNQSQSNTPPNSFSPPIQSIYGGLTPPASFMNLQLQAQAQAQAAVLGHSSPPTPEHLLRTGNPFNAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHA6</accession>
    <name>I4YHA6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_62717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956732.1">
        <property type="nucleotide sequence ID" value="XM_006956670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHA6"/>
    <dbReference type="GeneID" id="18474782"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62717"/>
    <dbReference type="eggNOG" id="KOG4774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091047_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHA6"/>
    <dbReference type="OMA" id="TEEAGWA"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="201" mass="22962" checksum="00FB8165EE570577" modified="2012-09-05" version="1">MDSEDKIIEDDVWGGSDDELENKQRDKDWNKLEDRFMDEGYREGISYGKEAHLQPGFDEGYITGVGYGREFGRLRAFANQTLSHLTNIQASPEQLERCRSLVSNIGRVSAHQILPKDIEAIEHAKEHEEEDRKQKSTSNVTFEEELGGERGRQRGVEQLADELDRLGKAKLDGRETLDELWGELKEILSRESTLESLLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF8</accession>
    <name>I4YHF8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_15719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956517.1">
        <property type="nucleotide sequence ID" value="XM_006956455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF8"/>
    <dbReference type="FunCoup" id="I4YHF8">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="GeneID" id="18470672"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15719"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034597_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHF8"/>
    <dbReference type="OMA" id="MPVYYSH"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="25614" checksum="1319C6099311CC8D" modified="2012-09-05" version="1" fragment="single">FGVSAISHLISERYLSATYEKLDKNQKLDWNAHTVSLVHSLLIAPAAGYALYKSPIALTDTLYGYDSLIGNIHAFSLGYFLWDALHDVRTRQPVYLVHALVSFSAYLWTFRPVFMNIGPAFLLWEASTPFVNINWFMDRIEGYKNSRSQIVNGIALTLSFFTARIAFGGYMSYIFYKTIVEHQNSFPKSLAAVYVAGNITLNILNLNWFYKMMKKIKRMYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI3</accession>
    <name>I4YHI3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_15268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956499.1">
        <property type="nucleotide sequence ID" value="XM_006956437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI3"/>
    <dbReference type="GeneID" id="18470654"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15268"/>
    <dbReference type="eggNOG" id="KOG4550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020272_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHI3"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="9">
        <location>
            <begin position="501"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="650" mass="72087" checksum="79945099EB3E5C34" modified="2012-09-05" version="1">MRIIDNRILLATTSLTTLAYGWDISTKQRFTQDGLIDAGELGLDGISGRVSALGDLNGDQYLDILSVDADQKTIRSHLWNHDKYTFESNSTVSVPFKISTLVATDIDHDGKLDVMAVGEGRTTTEIQLYLFHGDGNGGFESPVQLPNISYTQPTFFDAQGRLSNDFLAYRYDAGTKDDQLSLYSNTLDDRDQPYDIIEPNFDTSTGTPCKMSQTHSNAFIDLNGDCLADLFLVCSGHEPSYQIWLNNPANDNFVLHSQNSLPKGTGMISFADFDRDGTIDMIFPTCESTTRDGLGKSCSINVVFNKQIPLCVDSRSFEALLHPSLISGGGGECRSPSELCVADDKFEYNQEKRLKIPIEQLTQNSNLRLKMVDHSLQPGLPLSLKIGDYNLDGFPDILCLLSDGSTTRGAILDNVLVNKTRSLTLRDDSKTTILKDIKDVRAASWIDIDEDGSLDIMLQRLNSVTFIKNNIANDAFFIKTLMLNGACENWCDSPTAGRYKPFGVNAIGGTYKFTILDTNGKRMAASIPQLPSTAFDALLTPYSVIGLGRTNNYIENLHVGSTSKNGSSQHMNFEGIIPNSQVIITPAYYNHDWHIEMYLKTNKWIPFVTVVVAVLCVLFGAVVFGLHIHEKKEDEAERRKESHHINFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI8</accession>
    <name>I4YHI8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956805.1">
        <property type="nucleotide sequence ID" value="XM_006956743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI8"/>
    <dbReference type="STRING" id="671144.I4YHI8"/>
    <dbReference type="GeneID" id="18475283"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67683"/>
    <dbReference type="HOGENOM" id="CLU_494497_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHI8"/>
    <dbReference type="OMA" id="HILAHLT"/>
    <dbReference type="OrthoDB" id="3356936at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="616" mass="71045" checksum="7E622270355BEB23" modified="2012-09-05" version="1">MSEKQMNNFFQLEYFAPTSYWESFTRTPTNTQWKSLSPSSEPDFSLFEPTDYEPVSSNPAVDNKAPCTVLRDMTRKQQFIAAREILSDLRQMNVPIRQSQVYTIAAIERLLDNDIEGATAWLPLIPQRAFHASHILHIFFANDPTNLDALVLLARKLPLSANQATHVLAHLVRFSQDTLKVVKFLEDQETKSQVWNNQRDVFLNQLALTKRFDDLDNVLKRWCTKYSSPSQTQETRKMYIPSAFTSILILQESIKNNANERLVRQAQWILSNYHSEEAKRMAHAPSLGPKSASREIEENLLEEISQTRPNDKVVKRLLQELFADSSFPSAKVISSLVTYYQTKIHTIKIAPRLAELRDYLLNRQHLRQRAKSLWTFSRMIMQLHNSIYAPDHKRDMKAKRVLEIFSDVYLPIGIPDNLISKPSNGFDNILNTYKSKSHPLLLWPDPFVLGVAYTSLLIIHKNDKVLHNRLWRNLISPATTTSNDFIFTIPPSMRPDSLTCLPFLHIFSTKHNPDRVREALEDMANCGIPFAMEGILTLLRAYASRNRLNSVRQILNWLQHQESEFNIPRWDPPENVSVEALIPHLVDVSPLNSQTRAFLERLLQKDVESESGGDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL2</accession>
    <name>I4YHL2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_31521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956826.1">
        <property type="nucleotide sequence ID" value="XM_006956764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL2"/>
    <dbReference type="FunCoup" id="I4YHL2">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHL2"/>
    <dbReference type="GeneID" id="18471321"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31521"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_1_1_1"/>
    <dbReference type="InParanoid" id="I4YHL2"/>
    <dbReference type="OMA" id="YHEFHED"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="482" mass="53674" checksum="607B87DFF52330C7" modified="2012-09-05" version="1" fragment="single">MTSRTSSYLSDRLNSLSIELDSFPISDKALKNGGNISKSLSLLVKDHSLQTATKALNNINVEKGESELEWLLLARVTLVLYDNIVASLLNHAVELNSLSNFWERTLESRFKSYNYLLQTLPNRAFNYAKNSHPSIHSLFPYSQVGLSLNLRTLTFEPLNLLKFELQSHIDEIGILKDDIANSVGLLASFNGLKDGFGPDNKGNTGRSLGGDLNNWIKHIKSVLNTLTKDDQVKVNEATSFRAILDNLKTLVENVIPSHTASITRRVEVHKRPSTLTRCWPKLLIGPPVLLVIARLVLRSQDAVKAYLRDIGETARGFVQSWIVEPATHIINTIRFGGRGLGVTEAGLESDIASLERMVKDLGKENLKLSDAQLLELGNNVRKGDLSTVLQVYENEMKTPFKSALFGQLVRALLIQIQKVKCDVDTTMTKLDALLKSQELTFGFVGVAPSLAIVYFVGSWFSRFLGLIVGKKEISLKRRVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ3</accession>
    <name>I4YHQ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956173.1">
        <property type="nucleotide sequence ID" value="XM_006956111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ3"/>
    <dbReference type="GeneID" id="18471232"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31024"/>
    <dbReference type="eggNOG" id="ENOG502QSYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_3_1_1"/>
    <dbReference type="InParanoid" id="I4YHQ3"/>
    <dbReference type="OMA" id="RMVAMFI"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="87"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="57297" checksum="6CCBE6C56D44FDCA" modified="2012-09-05" version="1">MADKLENNNTAQPVADASSPAEDSSKNVSSSNKLDTTDTSKSVTNEPSTESPVQDLAVANRIQGLPPFTIEDKQNSTPMPKQQRNTRRLIICCDGTWQDAMQTRAEDEYTNILRLSRAIKQEDRRQDPPIPQICHYISGVGTGWSISDKIIGGATGNTLGVKLRDAYAFLSQNYCDGDEIFLFGFSRGAFTARTLGALINDIGILDNKEMEHFFDIFQAYNDRNNKLDKKKAEEAQKLLDPWLLINENNQRHKGRQFIIKCIGVFDTVGALGVPTLGSTLFKMHKGENYLGFPDTVLGDKVEHCYHALALHENRPNFIDTRFEVKKNNLERGQHCKQVWFTGCHSDIGGSYKEHELSDLTLIWMCACIESLLLLDIEYIKTIPDPMEGWGKQKPHDSKTGIFTFSMPIKRKPVLELSSTERLHPSVLQNDCKLAKSIQDKIDAEPHLVAHLLPLEEQFKSAWKVAANAQKRKDSSKYQTSKDQKSFDELEVETLFRKYWNKAKSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ4</accession>
    <name>I4YHQ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956174.1">
        <property type="nucleotide sequence ID" value="XM_006956112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ4"/>
    <dbReference type="GeneID" id="18473238"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59232"/>
    <dbReference type="eggNOG" id="ENOG502SP1X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215602_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHQ4"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25246" checksum="65DD5D5E629A2ADA" modified="2012-09-05" version="1" fragment="single">MTTLSELLPSRSRLTIIRDEPGCLGHFILIDQLKNAQMAQYPTTILATEHSKEHWMACVKKLGSPFHASTSYIDGLNKLAEGKENTLKELLEETTNSLRAHRQSDTPSKLLIDDLACLSWLGFPDSDIEWFVKSLLKMAEEIDADIVTIVHSPHHAALVESFSSIAIVTEPLSTGPSAEVTGQIKAYRGPLWDYTDSKPTGWIGWEKQFHLGDSSVDIFAKGLGKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT4</accession>
    <name>I4YHT4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956203.1">
        <property type="nucleotide sequence ID" value="XM_006956141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT4"/>
    <dbReference type="STRING" id="671144.I4YHT4"/>
    <dbReference type="GeneID" id="18473247"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59247"/>
    <dbReference type="eggNOG" id="ENOG502SKDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671223_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHT4"/>
    <dbReference type="OMA" id="NTYSEYP"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698020" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45331" checksum="230ED65329AEB286" modified="2012-09-05" version="1">MNFIVIITLLSLLSYSSSFSFNVTSKKQCDTFELNWSGAKQGSVSFVAIPNGNPPDESKPDRVLVAQDIGDDVSGTYKFDRWPMAEGVNFTVTMSDGTGFGAGGTSDILVTELGDAPYYCGYSGNLAFSFYAEPEKNWDSCQTISLHPINKTTDSAFDYYAISPNSKPEHIERVTDNSAIVDYKFTQPVGSQVIIFATSEEGGVQYSSGGSSQITTLGKGDDTSCVKDLEPSPTDRAAPTNTGGSGSGDLSGGEKAGAAVGSILGAAALIGAIVAFIIFRRKKSAENHEHAQKVKNDHGYNSEFDEGLDGSYTPYVMNPGSHYTSSHHQLPTETQGLTETDVNRNSYSNATIPASPSTGGLLLGSNPKRRSGHQQQESTISKEPRYHTDAGPYVVHNDNDDDALVDVPPAYNFDGPNNHEHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA7</accession>
    <name>I4YIA7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_62366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956365.1">
        <property type="nucleotide sequence ID" value="XM_006956303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA7"/>
    <dbReference type="STRING" id="671144.I4YIA7"/>
    <dbReference type="GeneID" id="18474742"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62366"/>
    <dbReference type="eggNOG" id="ENOG502S13M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_3_0_1"/>
    <dbReference type="InParanoid" id="I4YIA7"/>
    <dbReference type="OMA" id="IRMDFEA"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16095" checksum="977ECDE5BCD40844" modified="2012-09-05" version="1">MNSYQSGQTPQPLYGDIQDSDNLEAGHAVGAWETRFGWRVDVEAASAYVLGPISALLLLIFETTSDYIRYHAYQSALLSAILALLHFVLLILRFPSIFNWCAILLDIFALGKTALHAYRDSQSLERYPLPYIGEIANRWVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIF1</accession>
    <name>I4YIF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_31237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956408.1">
        <property type="nucleotide sequence ID" value="XM_006956346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIF1"/>
    <dbReference type="FunCoup" id="I4YIF1">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIF1"/>
    <dbReference type="GeneID" id="18471269"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31237"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_6_1_1"/>
    <dbReference type="InParanoid" id="I4YIF1"/>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="116"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="346"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="559" mass="62628" checksum="D23261BBF22AE2A9" modified="2012-09-05" version="1">MSTNEPPQHIKDQEATSQASAQSSPSTPSQPLGMEQLHHQQSQTTQNLHPVRSHGNLPDIERLKLESGPISPTPYSASSGGILKQLDQSTNASRLASRAPSRAPSVAGIGKTAAKPDYSEAKIVVAMVGLPARGKSYLSNKLMRYLKWLEYDVKVFNVGQYRRKLAREKKAATGAKDDHSASFFNPNNADAMGMRETMANDCLEHLIDWLKQGGNVGIHDATNSTMERRQKLAERISKERGMQIIFIESVCEDPKVISANVAGKVSAGDPDYNGMTPEQAEADFRRRISHYEAAYEPVNEPHISYCKVINVGQKVQCNLINGYLQSRIAFYLMNLHVSPRSIYLTRHGESMYNVEGRIGGDSDLSPRGSRYAQALPNLVRDNVGDVPLTLWTSTLKRTIQTAANLPYPKLTWKSLDELDAGVCDGMTYEEIEENYPEDYANRDEDKYNYRYRGGESYRDVVIRLEPIIMEMERQNNVLVICHQAILRAIYGYFHNIPQEEIPYIKIPLHTVIKLTPKAYGCDEVRYQLPIEAVDTHRPKPTIKRSDSKSSKASAPSSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ9</accession>
    <name>I4YIJ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956454.1">
        <property type="nucleotide sequence ID" value="XM_006956392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ9"/>
    <dbReference type="GeneID" id="18471275"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31274"/>
    <dbReference type="HOGENOM" id="CLU_824398_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIJ9"/>
    <dbReference type="OMA" id="HERDNGN"/>
    <dbReference type="OrthoDB" id="10461027at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698969" evidence="1">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="36352" checksum="17E077BCE048419F" modified="2012-09-05" version="1">MIAKLALLASIASAVIAAPVTSQFNINKRILDDETDDGKGILFLNTRANDYDAQLIDNDKVNLLKARQEGGDLENDLENPFKARHNDDDDSLVDLHVLKRILGSNSGKDGEGNILGVGVLKRAHDLTDSSGTIDIDLLQRRGALGIGGNGYRDSTLGLFGRIFNENPHDDDPLIGVLKRGGLLSNHADHDNTISLGISKRGGILNDGSPEFAHIGIKRRGLLSDNDDKLHVGVKRDEVDYEKESIGLRILDKRSDDEIAGLDLELRDLSDDEAVIVRRVLGLTDGGRDNGNLKIDNPVGLRRDDVADNKKDKEYDAQLATGACLLNGCDTGGGVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL1</accession>
    <name>I4YIL1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956466.1">
        <property type="nucleotide sequence ID" value="XM_006956404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIL1"/>
    <dbReference type="GeneID" id="18472792"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56296"/>
    <dbReference type="HOGENOM" id="CLU_152126_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIL1"/>
    <dbReference type="OMA" id="ACKPRAF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="14659" checksum="7A4ACC01CE99FDF4" modified="2012-09-05" version="1">MFMKQITRQTQRSFATTTPIRYSIANTVKQTVFGKDEKQKAEEKAEVMKEKAKATGDRVYVKGSDLAGEAKQGMSEAADSAQGNAEVGKQKAEEKAEDVKPHVESASQKAKEFGHETAKKVSDASEKFQEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP3</accession>
    <name>I4YIP3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_34319</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955682.1">
        <property type="nucleotide sequence ID" value="XM_006955620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP3"/>
    <dbReference type="FunCoup" id="I4YIP3">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIP3"/>
    <dbReference type="GeneID" id="18471857"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34319"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_1"/>
    <dbReference type="InParanoid" id="I4YIP3"/>
    <dbReference type="OMA" id="WRANMRR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="28"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="344"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="642" mass="72017" checksum="79DE6BD5DBB1E27C" modified="2012-09-05" version="1">MGTFFKRMYDLGDILWPRNSVYLQSVAFFCLGLLVAGRYINLVVPIQLGKVIQDLTAFSSPWKHLALYLVLRFFQGSGGLLQVIQSVAWIPITQWTDQKMSTHCFTHLLNLSLAFHTHRKTGEILRILDKGAALNGFFQILLFNIFPTIADILVALGYFFFKFGPLLSIIIATVMFLYGFISIVITRWRTEQRRDYVAKDNATKAIYTDALLNYDTIKYFTAEDNEINRYTRAFKDFQAVEKKVIASLYLLNMAQNIIIVSGIATGTAVVCAGIIKNKAEAAELVVFLTFLQQLYVPLNNLGSIYRAINTSLVDSERLMQLLAEPTDINDKPNAITLETRQPVIKFENVGFSYDTTNDALSGLSFDVPTGKTVALVGESGSGKSTILRLLYRFYDIKEGSINIDGIDIRDMKQQSLRKHIAIIPQDCALFNETIAFNLKYGKENASEEEIMNAARAAQMHERVLSFSNGYDTRVGERGVRLSGGEKQRIAIARALLKDAPILCLDEATSALDTNTEREIQSAFNELSQGRTTIIIAHRLSTIAKADKILFIQNGRVTESGTHSELLSQNGEFARMWAKQVEGEVDELNELSKQDVETNGGESSSIVKTTSNESNTSNQSYTKNAQNKKNKQKNKRRNKGKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJF3</accession>
    <name>I4YJF3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955921.1">
        <property type="nucleotide sequence ID" value="XM_006955859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJF3"/>
    <dbReference type="GeneID" id="18473164"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59085"/>
    <dbReference type="HOGENOM" id="CLU_1273131_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJF3"/>
    <dbReference type="OMA" id="SHIMREN"/>
    <dbReference type="OrthoDB" id="10575567at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="200" mass="22245" checksum="4D698D3DD5182D2B" modified="2012-09-05" version="1">MPHSRNSSTHSHFIRENSPPSEPIGLGADRIEEGAGHAEEAEEHNFRLASAFDIPPAYEERKGRSHQRSHSRQHDRSQSRQFRSRSRHASNPNSAANSRRASPAAPASRNQSQEPEVSQHSQQQQHPHESHQRNNSEIQGVSQNLPELGYGQSKNGHSHESNAGVERKRSQYMGIGADRIDEGKGGASMGQYMQFSSDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL3</accession>
    <name>I4YJL3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_14124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955660.1">
        <property type="nucleotide sequence ID" value="XM_006955598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL3"/>
    <dbReference type="FunCoup" id="I4YJL3">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJL3"/>
    <dbReference type="GeneID" id="18470624"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14124"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJL3"/>
    <dbReference type="OMA" id="YVFHSVD"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="416" mass="47190" checksum="370A2E07188CF159" modified="2012-09-05" version="1">MNNVNLASFFIPSDLHKDITEKHENQLRAPPPGLRLPERLHVYRELYPLDDGTGPALGLAGLTTYAYRATSERDGSRFCLRRVEGFRLTSQEPLSAIDRWKRLKHPNIVPIAEAFSTRAFNDSSLILSYAYYPNSHTLANLHSPNPLNPSPPPLSEKQMWTYLLQIVSALMYVHNQGLAVRCLHPSRILVSSKNRIRLNCLGALDILAYDDFANVNLQQQEDLVSVGTLLLSLALGNSKAVTSNPTKAIEYFSRQYGPDLQRIVLWLLGNRSPLKTAEELWSMITKINPGIVAEVIDSSLTANDRLDNELSKEVENGRLVRLLCKFNFINERAEFDFDPRWSETGDRYIIKLFRDYVFHQVDENGKPVLDMSHVLVCLNKLDAGVDESIMLISRDEQSCLVVSYKEVKQCVESAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y553</accession>
    <name>I4Y553_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_70869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960851.1">
        <property type="nucleotide sequence ID" value="XM_006960789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y553"/>
    <dbReference type="FunCoup" id="I4Y553">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y553"/>
    <dbReference type="GeneID" id="18475807"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70869"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="InParanoid" id="I4Y553"/>
    <dbReference type="OMA" id="RRCTIAK"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotran_1_2"/>
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    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="84"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="440" mass="48861" checksum="8D92A3E79878A600" modified="2012-09-05" version="1">MTQLDSRHYEKWLTAQAKSRHPSVIRTLFPLENNPGIISLLAGKPNPETFPFENITVTLKPVSPGAPHPKLELNAGPDLAEALQYTATAGLPRLHKFVTELQHHVHGREPISGEDDFGITITNGSQDAFTKACAALIEQGDYVLIESPVYTGAIPEMTIAGAQFVEIDCDGQGMSAEKLSDVMENWPEDKPRPKLVYTVPTGNNPSGASAGKQRKIDILNLARKHDFLILEDDPYYFLTFDGGRVPSYFALEKELGGERGRVLRLDSMSKVLSSGLRIGWATGPKRLIQAMDLHTSSANLQPNSTSQAIVQQLFNHWGIEGLLDHVTRVAGFYRTKRDAFEKAAEKYMGDIATWVTPKAGMFLWLKLDVEDSNELIQERAIKNGVIALPGNVFYPTPRQTPYTRLSYSMASIEDAEEAFRRLRKTVFETKGIPDPKALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y578</accession>
    <name>I4Y578_WALMC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
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        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EIM19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y578"/>
    <dbReference type="GeneID" id="18474649"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61634"/>
    <dbReference type="HOGENOM" id="CLU_3070465_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y578"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="53" mass="6021" checksum="4CB97C39F01150E7" modified="2012-09-05" version="1">MRLFSYQSPAFFSVPDNYADSTLERGGQCLHWISLNVPDPIAITGAPFLEHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C9</accession>
    <name>I4Y5C9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_006960792.1">
        <property type="nucleotide sequence ID" value="XM_006960730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5C9"/>
    <dbReference type="GeneID" id="18475131"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66617"/>
    <dbReference type="HOGENOM" id="CLU_2833113_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5C9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="66" mass="7886" checksum="E09793C6E28AF996" modified="2012-09-05" version="1">MPLPGLNGESIPSPQDEYWCKNDNVNLYNEIQKLKQQRVANQSTYKQQQNTNNYTHQSQVRQEHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5K3</accession>
    <name>I4Y5K3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Noc2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960742.1">
        <property type="nucleotide sequence ID" value="XM_006960680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5K3"/>
    <dbReference type="FunCoup" id="I4Y5K3">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5K3"/>
    <dbReference type="GeneID" id="18474620"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61581"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5K3"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="639" mass="72339" checksum="5B58084DD835A166" modified="2012-09-05" version="1">MMYSIWNLARMRKKKTMMKRLSAEEAENSDVEQDEKSHAEAIKNLSKTDPEFFKFLQENDKNLLEFDESDDEQEDGEDDAGDNSDDDEAAALAEMEGSQSKTTKLTNKMLRDWQRAIINHRSLRSFKKLILAFRSAAFSTDMDDVPKKQSQNFTFEIDSADLFNKVVLTAFKYTPIVLAHHWPCKELPNGRFKLSPSPNSILPKLVSTYLNSALFLIGHFPATSDNLDDEQDESEGGILKVAVSEVGKVIPYVVGGRKGIKSLLKVLLELWSSAKDSVRIAAYMSIRKIALAGDTSVVDLTLKSTYLTFIRTCKQTSVHTLPSINLMKNTAAELYNMDHGASYQQAFGYIRQLAILLRGAMKTKSKESFRQVYNWQYVHCVDFWSLVLSWANDKSAPESELQALIYPLVQVSLGAIRLVPTSRYFPLRFHMIRSLLRLEQRTGAYIPIAAPLLEILSSAEFKRQPKKSTLKPIDFENYIRVPTTYSRTRVYVEGLADELVYILSEAFFTVGTSIAFPESIVPVVSILRKTIKKSPSGPKVVGQFKALVERLESQAKLIETERTKVDFSPGERGQIDRFMEATPVESTTLGSFVKILRKARDQKRSQSTEIKDDDDSDLEAAPDAEEVEDDEELEEMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Q2</accession>
    <name>I4Y5Q2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960686.1">
        <property type="nucleotide sequence ID" value="XM_006960624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Q2"/>
    <dbReference type="GeneID" id="18474599"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61551"/>
    <dbReference type="HOGENOM" id="CLU_928138_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Q2"/>
    <dbReference type="OMA" id="RICLRFE"/>
    <dbReference type="OrthoDB" id="3357845at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="300" mass="33887" checksum="F41E7A981ED19E6C" modified="2012-09-05" version="1">MPDDLVISCFMAVSRALFISTLLMLISPAWYFAITKVISGKCSARTFSALFLTTMVLVMVTYLILEMTFRLYLWFDTHMRYLDIIIGIFLIHISLYALIGVAFMIRFHLYAHRIEVVLILTAAIVPMVNGSIRLSKDVFVDQTYVILQGVEALSYILILFVKASMALQWEDSRFPRQTINTRDVENVPSVNVGAILPWRVTSSQTIAYPKTVLGSYHFTNLESCKDLYSSEVGTPTSSTKDPFEYDNTRSATMRRSKIQPSIAINDEDTPDSVTAIQGTNIPVAAYIIQTHLDDNSQYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Z4</accession>
    <name>I4Y5Z4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">WALSEDRAFT_66368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960536.1">
        <property type="nucleotide sequence ID" value="XM_006960474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Z4"/>
    <dbReference type="FunCoup" id="I4Y5Z4">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Z4"/>
    <dbReference type="GeneID" id="18475110"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66368"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Z4"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="428" mass="46718" checksum="8E46E864DE7659B8" modified="2012-09-05" version="1">MSEEDKVNNVPVILHSISSQHAIPEEMYMIPSNWKRYQLSQLINSLLENSKAIPFDFFVGEDGTGGKLSSVLSEISNGEETLHLSYIPSILPPKHLSTYLHDDWISSVSIRSHSDAKFLTGSYDGLASIWNSRNEKIYELAGHNGPVLDLSWVGDKAVTAGQDSTLKLWDIPESGKPSQLLAYTGHKNAVSSVRSAKPLTEGEPWTVLSADWDGLVCLWDTHIPSSHEVEIEDEEPSTKKRKKTKTVDVLRKAPLHQLRGHTGSVNGVAFSKSDPTVGYTGGADHSLKSWDLGVGLENDTRVGSSVIRCLDSLVAPSTIVSGHVDRSIALWDMRASSNISQKLLGHTSIVEAIHAHPTSPNHFASAGMDGNIKLWDIRSPKQSLFTVVRKPSNGKKENEKKILGLAWDSQILASGGEDCALQLHEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y601</accession>
    <name>I4Y601_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_55601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960543.1">
        <property type="nucleotide sequence ID" value="XM_006960481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y601"/>
    <dbReference type="GeneID" id="18472738"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55601"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157172_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y601"/>
    <dbReference type="OMA" id="RRSTHAC"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044520">
        <property type="entry name" value="ARF_GAP_AGD5/15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="104"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="27745" checksum="B7BABB5654A454B7" modified="2012-09-05" version="1">MREWLSNVNVFHYRKPSIVRRKRRASDTQKETNDQGLSSKSLARLKPMVVSNDNTKEQLELDSIDMRINDKVEKMANKVKNRTSLPAPNKMKQSQNTLFDAYDIAKISELRNNDSNYLAIRRVLAKPHNRCCADCRSPDPLWASWQLDLIPMVIFICINCSGWHRSLGSHISKVKSIELDDWTTEQIKLADRTGNDKCNLYWEANKPSDIPIPKPNTSEIGSYITCKYKDKLWVDSRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D4</accession>
    <name>I4Y6D4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960450.1">
        <property type="nucleotide sequence ID" value="XM_006960388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D4"/>
    <dbReference type="GeneID" id="18474531"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61431"/>
    <dbReference type="HOGENOM" id="CLU_994668_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="268" mass="30280" checksum="BD2215E11D32992F" modified="2012-09-05" version="1">MVTLGGGAFAGGFFAVVDRCTRRNGVINGRECLQAVLFEILIAAIYGIGRYGQETGAFKRESYEVNKGFSSMTTLPISVLEDYERTSPENRIKFGSFSVADVEGSEQWESYEDDSVFHVFNVKDEESPYGHHPAVIHRFYSETRTHEVSSLNYLMEEGVKRQIGNNDRWVYSYAANSQSFGLNQEHYPNVPVDTIEQMSYDLLGRLDELGADNIRIDINGQLGKWGKLQVANGDTQGGIGPTQCESYYNNDYADGNRWHYTYQVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6E0</accession>
    <name>I4Y6E0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960455.1">
        <property type="nucleotide sequence ID" value="XM_006960393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6E0"/>
    <dbReference type="FunCoup" id="I4Y6E0">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6E0"/>
    <dbReference type="GeneID" id="18471788"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33999"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6E0"/>
    <dbReference type="OMA" id="HVDVLTN"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="645" mass="71873" checksum="6DB165670AF7BC28" modified="2012-09-05" version="1">MIARNYYRTARTVSRTGILRQQIRYQSTASSPNPSDQLWRRFVVKPAKYAAFAGGSIVFGISAFITIIFAHDAMTYKGSNVDKVHVNPLSLAPQTGGKKNLPITNVFMDDEEDPEAQSISKKPHLVIIGNGWGGIGVLKELEHGDYKVTVISPANHTLFTPLLPSAAVGTVEIRSLVEPLRKLVARLRGHYISGAAADIDMGNRLIEVHSKRPDGSVDQFYVPYDKVVIAVGANTASHGVPGLEHCYQLKTVGDVLRIRRTIMQNLEAAALPTTSQEERKRLLSFVICGGGPTGIEMAAEIFDVLNEEVGKYFPKLLRKEISVHVIQSRDHILNTYSEKISEYAEKKFAKDEIDVILNARVSRVEKDRMMYTLKTDKGEKVEHEIPSGFILWSTGLGMNPFAKRVCEQLPNQFHSKAIIVDSHMRVKGAPQGTVYAIGDNATVDNNLLDALLDLVDDCDKDQDGKIDFEEFEIMSQKLRHRFPLAKAHLQKIRKIFQQYDKDQDNVLDLNELASLFSEISSKIVSLPATAQVASQEGKYLGKKLSKLATARDRLTGTDMVNEAGDVDDEVVAVPFSYRHLGSLAYIGNSAVFDFGSPDLSFAGGLISLYLWRSIYWSEQVSNRTRALVMIDWIKRGIWGRDLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I5</accession>
    <name>I4Y6I5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960375.1">
        <property type="nucleotide sequence ID" value="XM_006960313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I5"/>
    <dbReference type="FunCoup" id="I4Y6I5">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6I5"/>
    <dbReference type="GeneID" id="18474509"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61398"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027451_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y6I5"/>
    <dbReference type="OMA" id="RVWVNQL"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="198"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="358" mass="40731" checksum="C66AF159F011E2D9" modified="2012-09-05" version="1">MSSSDSDKESLAEQPEKIAEEQPEEPQEKALSHKERRKQRRAEALAKEKPEADTEQSSEQKEDSEKTEKVESRPQRSAYAVWIGNLSFKTTRERLFEWISTNIQESEDVITRINMPKGQRAHEHNKGFAYVDITTEDIMNKVIAQSENNLDGRKLLIKSASDFGGRPKPQLPEGVSNENDLSKFSKKILSSQQNKPNPTLFFGNLSFETTEESIKSWLISNAEKLHTRQKQQQKVDQESKLDVGVKRIRLGTFPDSGKCKGWCFIDFKNTTQATSALCDSHNHRMYGRDLVVQFGQDRSEQKKRKYDKEAEKEDTNERPDNRKPKRAKPGAALANAQRSEKASGAINQPSAGTKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J0</accession>
    <name>I4Y6J0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_48843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960380.1">
        <property type="nucleotide sequence ID" value="XM_006960318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J0"/>
    <dbReference type="FunCoup" id="I4Y6J0">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6J0"/>
    <dbReference type="GeneID" id="18472472"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48843"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y6J0"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="288"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="411" mass="45319" checksum="F3AB67E6A7E78A0C" modified="2012-09-05" version="1">MVTKAVILTGGPSRGTTFRPLNLAQDMPKPLFPLGGKPMIWHQLQALSEVSDCTEVFLIGFWPEETFAAFVNESNIEFKDHFNVRYLREWQELGTGGGTYHFRDLIAKGSPTAFFVIHSDIACAFPLNDLRSFHERHRGVGTIQAARVNKDVAHKYGCIVSNENALAIHYAEKPDSFVSDLVSTGVYLFDVSLFSEIKAIMDSHYYKQLASEEIGFDEEILRLEQDVIRPLADAQKMYVFETDVPWRPIKSAGSALPANALYLGQYQSKQSKLLYSEPAESESDHAEIIQPVTIDPSATISKGCKIGPFVSIGPNVVIKEGARIAHSIIQRNTVVEAHGCIVYSIIGARCRLAPWARVEGQPFTGDESAPTQSGICILACDVLVTRDVLIRSCIVLPNKSLSTSAACQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y790</accession>
    <name>I4Y790_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960166.1">
        <property type="nucleotide sequence ID" value="XM_006960104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y790"/>
    <dbReference type="STRING" id="671144.I4Y790"/>
    <dbReference type="GeneID" id="18474448"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61302"/>
    <dbReference type="eggNOG" id="KOG3859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597452_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y790"/>
    <dbReference type="OMA" id="RWARESM"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="103"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="458" mass="51708" checksum="047F72B6BFF11D0E" modified="2012-09-05" version="1">MVSFLQSCRNSFRKEKRNTVHLDNVKASPSLPDLGETLGKPSRFADEIAQSVQGLDFKRDDFSPNHLQVPQNLNVRLSTVSDNTRRFTKPNSLTSRNARRRKTPRSLNVMVAGGIRTGKTSLLRLILDTVKLSPTSNITQRTEATISFTNKHQPKQPLYQMSFDVGGDVNSDRTMLTLTDTPGLNYQDSQQLSENTDMIIKHIEHLYTQTLEEESRVNRSNSSQALDRHIHVCVYMIDPARLIESHNGSLTLQPTELQTIISLAKRVNILPVIAHADSLTDNTLRLAKDGILSDLANIGFKFEILGLNERASTPDSNAHLSDLDDDHNNSTKLIKIRHRAKSATPSVASTDNSHMTNLDPVPYAIVIPERFDKPSTTRNFRWGVVDVLDNQHTDYNALYDVLFGNNSDSLRIRTRETLYESFRREALISRQKDADSGPKNLSSIRNSNIYKKRQTSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7P7</accession>
    <name>I4Y7P7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_21305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959920.1">
        <property type="nucleotide sequence ID" value="XM_006959858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7P7"/>
    <dbReference type="FunCoup" id="I4Y7P7">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7P7"/>
    <dbReference type="GeneID" id="18470881"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21305"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_16_1"/>
    <dbReference type="InParanoid" id="I4Y7P7"/>
    <dbReference type="OMA" id="RHHIQSF"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="384" mass="43933" checksum="3AADC9F30F33597B" modified="2012-09-05" version="1">MASASTSTSASVVNGVTNGNKRKKARNASPQTVPLPVPCDDKEGHLIIIENSELDGRYRIQKLLGQGTFGKVVECYDRLARKNVAVKIIKSIQKYRDASRIELRVLNKLRDNDPSNLHKCIEMIDWFDFKNHICIVSDLLSESVYDFLKSNKFTPFPLTQIQEISFQLLKSVAYLHSLGLIHTDLKPENILLVSNKSRMELATERRPQRKVLMDTDIRLIDFGSATFENEYHSSVVSTRHYRAPEIILGLGWSYPCDVFSLGCIIIELITGEALFQTHDNLEHLAMMEIVMGKMSEDFARRSSRVKPEFFRGTKLDYPNNTTTKQSKKVVKAMKSIDQIIKTRDLSSLQLIDLLQKMLTFDQDKRIKISDALQHPYFKSKIFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R2</accession>
    <name>I4Y7R2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_52416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959934.1">
        <property type="nucleotide sequence ID" value="XM_006959872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R2"/>
    <dbReference type="FunCoup" id="I4Y7R2">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7R2"/>
    <dbReference type="GeneID" id="18472582"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52416"/>
    <dbReference type="eggNOG" id="KOG1732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7R2"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18480" checksum="86EC6020399D1554" modified="2012-09-05" version="1">MPHSFGLRARTRHLFSRNFKEHGPIRLETYLTPYKVGDIVDIKANPGEQRGMPHKFYHGRTGIVFNVAPRAVGVIVYKVVRSRYIEKRVNIRIEHVKHSKCREEFLRRVKDNRKALTDAKAKGERVNLKRQPAQPRQGHILKSKTTPETIAPIAYDTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7X0</accession>
    <name>I4Y7X0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959991.1">
        <property type="nucleotide sequence ID" value="XM_006959929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7X0"/>
    <dbReference type="STRING" id="671144.I4Y7X0"/>
    <dbReference type="GeneID" id="18474401"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61222"/>
    <dbReference type="HOGENOM" id="CLU_800683_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7X0"/>
    <dbReference type="OMA" id="NMAPNDY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="347" mass="35441" checksum="08A204C4CE4BFF12" modified="2012-09-05" version="1" fragment="single">MSNPHPYASKTRNSRRFKRSNKRDIWYDDGGSTDVLATGTPAPSYAFPTPATDGRTTIIGEDVRSLANQSRMSMQSVPTQSVISQLSLASQSILSSQSVISQQNSLASQSSASVISQISASSASSAASSRSSASSASSASSQSSVSSESSVSSESSVSSISSQSNLSTLSSQSNLSSISTLSTASTSASPDATLSNSDSGNDKAWIAGPIVGSIVGFLALVGLILFLATRKRNKNRALQAKEAQEAALMSGGGGATAAAGGAGAGAASSVNATPSQNNNMLGVGAAAGSRRSSTPSSHSRRDSLLARSNSDRSMFRSQSEHSFSHWDQQSRNSHDLLSAAPNNNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Z8</accession>
    <name>I4Y7Z8_WALMC</name>
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        <submittedName>
            <fullName evidence="5">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959811.1">
        <property type="nucleotide sequence ID" value="XM_006959749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Z8"/>
    <dbReference type="STRING" id="671144.I4Y7Z8"/>
    <dbReference type="GeneID" id="18474340"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61116"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611399_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Z8"/>
    <dbReference type="OMA" id="HEYLECQ"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="397" mass="45357" checksum="C9FBE3FE10301488" modified="2012-09-05" version="1">MSHLFLIPLNNSFELKIIALADNEKVKIGRQTNQRTLPKQSNGYFDSKVLSRQHAEIWSANNKIYIKDVKSSNGTFLNNERLSPEGVESSSVELENNNLLEFGIDIIGDDNKSIIHRKVSSKCMISHNQQEFLNLKQELNKFDSNKSYNLNKCFDNLEKEIKESRELGAGLSGISNHFSQIKDTLNGQLPVEIPQIDTNNVDVSNIQQHLSKFNQRLQQQQEFYQQLLADHSSLKSKLQEKDDQQPPQRDIHEGEDNSDASSIMTTKPDDKPDYEELIQQNQSLASRITTLSDELSVLQQQSTLFNDKIAQVEGNQKNWQTVYDNALKSNKQSQKEDLESAINIFRREQEQQSKRIDSLQKKTEKSLKDDKSLKFAGIISIFILGLAAITVFRGNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y852</accession>
    <name>I4Y852_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959865.1">
        <property type="nucleotide sequence ID" value="XM_006959803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y852"/>
    <dbReference type="FunCoup" id="I4Y852">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y852"/>
    <dbReference type="GeneID" id="18473010"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58365"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556917_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y852"/>
    <dbReference type="OMA" id="ILIRHQW"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="384"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="490" mass="55591" checksum="6F9FDAAA496E2378" modified="2012-09-05" version="1">MLDEKVDRLQTILEIDDSALASTLLDDSGWDIELAVENYFNSQASSTENTENSNTSATPYRLPISPSIAHVGLGSGRSAQAGSFIWTIWRGILWLAIKILRLPLWLYSFLFNQSVSFTPPEPVPQEEAHSLLLSSIDEAVNSREPSSSSTAVARTTQRQNTHVIPSLYLGTHSNALRDVKNNAQFGIIAFIDSSTTSDDFKYHTLAEEKFNKLVNEHDCLVWVGDISTNRDAYDVAISKGIRIFPRVEVHSMQALPTSRNALVSVPTMSHLGSISGKDSLGEDFRNLLSSRYLNRVSPYLRRLRNEKYERQRATYIKEAADRAENERMQRDAENVLKKREESARSAKAAEDIAQQREKERNEKANNEVILREYRNWLKSTIPGEPADGIRLAFKLPDGRRVIRKFSPETSLETLYMFVDTIDVEMSTKKPTRVVDFEPEFKLYMSYPCEFIPNLSDRVISQSQNLIKGGIIAVESDIKEYSSEEEDYDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y860</accession>
    <name>I4Y860_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_55270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959873.1">
        <property type="nucleotide sequence ID" value="XM_006959811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y860"/>
    <dbReference type="FunCoup" id="I4Y860">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y860"/>
    <dbReference type="GeneID" id="18472724"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55270"/>
    <dbReference type="eggNOG" id="ENOG502S4WC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034228_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y860"/>
    <dbReference type="OMA" id="WDYVTKH"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="41608" checksum="BF7BEE49361AA89C" modified="2012-09-05" version="1">MLVNKLPKSRIFIRFYSTSHLPARNSWKKEFSFVGTKLRGRDTISCLDTARQFVKDVGIQEMGSSTTPVTVIDAYSGFGLVSKALLELENVGKVISIEPAHTFNKVLSALSDEHNNRMVYIDKDPYDWQVYTDIEQAGLLKDVQTRSWENIHDHFAVFMQVPATVHGEQLIGQFFHCMVFRSWLFNRGRIPMGLLINSPSYDRLVHSPGHPDRGRIATIREATAIIDVVIPEKDLLPENDKIYPQVRQPNKKTKKGANILNYVGTKITPHVDIIPDTTTLDAWEFVTRQIFITRRYSLRKSLKHLAVNADVALSKPLEDRGVDLDKLVRDLTIEEIAKIIDAFLEWPFRPEILYRDDVDDKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y887</accession>
    <name>I4Y887_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_69954</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959667.1">
        <property type="nucleotide sequence ID" value="XM_006959605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y887"/>
    <dbReference type="FunCoup" id="I4Y887">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y887"/>
    <dbReference type="GeneID" id="18475666"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69954"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019713_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y887"/>
    <dbReference type="OMA" id="YRQMQEY"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="735"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="557"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="788" mass="90860" checksum="C218E7FA14B0E34F" modified="2012-09-05" version="1">MDQKKRKLDDDGNSDLDNDNALLEQFRKEAIWRQMREYKRQYEHSLNRLQDLESKSNSLQSSLSSVEVCWNELIDVLQLVIVPSSSIQSNDALKDFLEYSNSEDLALLNSALSVRSGATKELIGSVLTTATRNQSPDAVHLQKQAHMYQQQSNSYKQELRLTRLQLDDCKSQWESTRDKLLNAEKQVDRVKSSLISKIHQETKPISSDSPIPQPKTDSVDQIKSEPSQAPSPVRETPQPPPPPGPTKEELEDARKLAMQRMTESVELRAEKIKLSQEVDSLRVTLRRPNDEAILESGLYRDLQQQIGHFQSDADTAKIKYNKLQKEFEGIFTSRREFEDRLKADANSQLDAALQKLQVKEADINRLRGQREELNSELNVRRTKDSTKLQHIEQTQQLSESRLERIRCLNSEIQRLKGRIAAGYGNENVYRAIMGDSVTEEDLNITIRLDTQLKTANEEIEALKSQISNLQSGGDLHVRLEQVETKLQSYEKAFSDPADPEVQNLVNQINKKDERIKTLELQNVESETTSNAIYGEIERLSKAWEVLDEQNRSKIFDLQHLEEKVSRLMTEKAKSDNKYFAAMRAKDAVDIERKTALRTHEKQSKTIERLVDTEKQLQQQISIHEKELMVYSSKTKALEDKVFTTERELSSARLLADESKRRLMEVSTKLNERHVMYEDERAAKKRLEEDNTKLRSDLQRIPHNQPVSSGAMNGIHNAKEENLQRERDQLFFLLRCSTCKNELKSHCITRCMHTLCKSCIDARIETRQRKCPICQIGFSSSDVQKLQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C3</accession>
    <name>I4Y8C3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_58266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959703.1">
        <property type="nucleotide sequence ID" value="XM_006959641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C3"/>
    <dbReference type="FunCoup" id="I4Y8C3">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8C3"/>
    <dbReference type="GeneID" id="18473002"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58266"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8C3"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="247" mass="28395" checksum="EFD4C8B7889B8F99" modified="2012-09-05" version="1">MANKTFREASSVHGRNPQHLIENVIRQRIYESAYWKEQCFALTAETIIDKAVEMQSIGGVYGNLRPLPFICLLLKLLQLQPEPEIILEYLQAVEFKYLRALAAMYTRLCFNSYQVFDILEPLLQDYRKLRLRNNSGYHITHMDEFVDELLTEERVCDIILPRLTKRDVLEQVHGLPIRKSPLDVEDDNSENEDDNISDRYVSRSPSPASDAGSDRYLSKSPSGSPVPQGEEEEDRYISRSPSPVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8F9</accession>
    <name>I4Y8F9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959739.1">
        <property type="nucleotide sequence ID" value="XM_006959677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8F9"/>
    <dbReference type="GeneID" id="18475674"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70009"/>
    <dbReference type="HOGENOM" id="CLU_2924473_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8F9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="61" mass="7072" checksum="5BB430822C43709B" modified="2012-09-05" version="1">MVLKMYKPVDYSSKSVPDNGNNEYFDESSKPWQCMMCGRNNVFTARYCANPTCSFDRNWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8S7</accession>
    <name>I4Y8S7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1168-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959626.1">
        <property type="nucleotide sequence ID" value="XM_006959564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8S7"/>
    <dbReference type="STRING" id="671144.I4Y8S7"/>
    <dbReference type="GeneID" id="18475025"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65498"/>
    <dbReference type="eggNOG" id="KOG4055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079129_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8S7"/>
    <dbReference type="OMA" id="MRINKLM"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="178" mass="20415" checksum="030458C0657E1A46" modified="2012-09-05" version="1">MTPVDYQKEQLDKLLEDPTKPVYIPDAPKKKEIAPAKEMFAHVQGSSAGAGSGEFHVYKQSRRREYDRVQLMEEERREEARAAEFEQRRREREAVAEAKTSKNRNRRNKRKQGKQDAKTKESNKEDDTEFKKRKIVGGTLPISEENSEKAPAVPVVEKTETPTVATENPITVVEDSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Y6</accession>
    <name>I4Y8Y6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959454.1">
        <property type="nucleotide sequence ID" value="XM_006959392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Y6"/>
    <dbReference type="FunCoup" id="I4Y8Y6">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Y6"/>
    <dbReference type="GeneID" id="18474244"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60913"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Y6"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="550" mass="62408" checksum="ED85FFDD255284F9" modified="2012-09-05" version="1">MNFELPELSTSDNQFGPHLNKIDNKFKEIPYSPYSKFDKITQIADFNNDLKEESNKQSTKQLKPLSKNIYGSGSATAFGYIHGEDEASFSLVDNKTSAKRTVALGRRQQQQRNNAQPAVRPTAQRTNTQQRQQAAQTQAKQQPRVNRKMGWKDWDKPNRIRDASVQVEPEWEKIAEIDFPRLNKLNLEVEEPTDVINYGQLYPYDRAFDRITTKNEKPLEIKDRVRYNPTTSVDPVIQKLANENKAKVFATDSVLSVLMTSARSVYPWDLVVVRKGDQIFLDKREGGPFDFISVNENAADPPMENDKETLNTPASLSFEATYVNHNYTTQVTNEQGKPKEFGEANPFASGDEPEPVASSVYKYRKFDLSLEESEEMDLIVRTELDAYVPGIKKKDPTPFITIKALNEFDHRAQGAGGALDWRTKLDSQRGAVVATEYKNNSVKLARWTVQSILAGAELMKFGFISRANPRDESKHVIVGVQTIKPRDFATQLSINLSNGFGIVRTIVDLVKNQPEGKYILIKDPNRSIIRLYSVPSNFDEAEETPQEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y914</accession>
    <name>I4Y914_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_47545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959482.1">
        <property type="nucleotide sequence ID" value="XM_006959420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y914"/>
    <dbReference type="FunCoup" id="I4Y914">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y914"/>
    <dbReference type="GeneID" id="18472419"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47545"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y914"/>
    <dbReference type="OMA" id="VQVYDHH"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="487" mass="55825" checksum="C61670B6622E340C" modified="2012-09-05" version="1">MVRPTDDQMLVNIPYEHMNNAVAGPDDPFRDKNNKPYQNLLNAHIEEQTMNDHDFMTLQRQYEGILRPDKKQRKTYAREDKGDLEVVDGDNEYRGPWAAWKDVAKPDEIEAPYEEDVEDWEIDRQKWLDDSSRSNASKTLLAQGGEKSVFHGSQLRDYQGRTYMHIPTDVDVNLYGEEGSQTNFLPKACIHTWAGHTKGVSRIKLFPGSGHLLLSASMDNKVKLWDVYNEGKCLRTFMGHYRAVKDVAFNNDGTRFLSASYDKQIKLWDTETGQCISAFTNNKSPQCITFNPDADKQDTFLAGMQDRKIIQVDLRTNEITQEYDQHLGPVNTLTFVDDNRRFVTTSDDKTMRAWDYDIPVVIKYIAEPDMHSMPAVGLHPTKKFLAAQSLDNQILIWAADTFKQNRRKRFAGHSLSGYACQLGFSPDGRYISSGDGAGNIVFWDWKTSRLLKKIKAHDRCVIDHAWLPHETSKVITASWDGAIKLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y922</accession>
    <name>I4Y922_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_69827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959490.1">
        <property type="nucleotide sequence ID" value="XM_006959428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y922"/>
    <dbReference type="FunCoup" id="I4Y922">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y922"/>
    <dbReference type="GeneID" id="18475650"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69827"/>
    <dbReference type="eggNOG" id="KOG1862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019270_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y922"/>
    <dbReference type="OMA" id="RQEFLRW"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="3">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="812" mass="88243" checksum="DE452F9E97645A34" modified="2012-09-05" version="1">MSYSKTELIETYKNLDIVAPDNIADSVLLSATKQTPANLSTKVPPTGQLNSHLKKRVSNNQKKQKTPSKPDWDNHSGWASRFKKSDDLFNKRPTKESVTSPNPTGLNNRHKKPPLEKEDSTAPVSSVLGSLALDADDELPAQLKNKLAPELPSSTPMSRVASSQGQHQATDWVYRDPSGNVQGPFKADLMQEWFLGSYFPSDLLVRRVDRDNFTPLQELLASVQDKSAPFHSAPLPAAPPALNVNALNQRFNASPVVSNASPAVDLLSPQATQSPLAGRLQQEGLYHPQPQVQRLANWDSRTSSPAASPFGRPLWGPNSPGVDVPDQHSREEFLMALRHRELLEQQAAQAQFIQQQMLQQQQQQQQHQEQLHHELELQRAWELQQQAQAEAQKQAQEQLDNTQTKDEADISVQVEAPESTIASVTEDGVMSPMKTPEPIPAVPTPQPSQKTVRGGVNVISQAELERVQRMSKQEGPVGKMGVSLSDVIDKQQQQHEEGEFAQPKKAAPAPWAPQEQGEKATAAPSLKEIQEAEARQSQARKQAQQAQRAAISQSQNASARIDDIVPGTLNWGLAGSAPQAAPAPQPTGPAWGGSNLNQKKTLRQIQEEEEAREREAQRKKMVASAQAASATRGYAASAQRTTVPSAGGAWTVVGQSNGAKPAPTAPAPAPVPAAPKQTTKPAQVPKPAPAVSVPPSIAQGGNVREPGAPSEEFIKWCKGALVGLNGTTSDELLPILLSFDIEKPDLELIQDMIYASSSTMDGRRFAGEFAKKRKEDSKGVSLSSAADIVKQQQAPKTLQETFKVVQKKKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9C8</accession>
    <name>I4Y9C8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959362.1">
        <property type="nucleotide sequence ID" value="XM_006959300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9C8"/>
    <dbReference type="FunCoup" id="I4Y9C8">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9C8"/>
    <dbReference type="GeneID" id="18474215"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60865"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y9C8"/>
    <dbReference type="OMA" id="NGHRRIW"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="130"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="408" mass="45314" checksum="55C14A561553C4B1" modified="2012-09-05" version="1">MMSIPIPVIKWLIPLTYFGLIATPVTSQFFFPATPILVWLLTFFCARFIPTPVRPTINVTILPTLESVWYGANISNLVTTHRHWILDVIAWFPYGLVHYVVPFVIAAIAWVYAPAKGAANRNGHKPYSALQFWGLVFGIMNIIGVIVQVSFPCAPPWYELLYGLLPADYSIPGSPAGLARIDELMHSHSYSSAFGASPLVFGAFPSLHAGSATVEALFMSHFFPKFKAFYWAYVGWLYWATMYLSHHYLVDAVAGACLATACFYILLPEHLRDPQGLPSNADIGKEKILPMSSVRSSNIGHRRIWSAAADSEFALDDLPSQLDSPLDGQNQSHLNLLPDSESRSSSISHANSAVHSRSQTPNKQPNQAPRISSSENHQEHPEEEILFDNEQNSPSTSSHTSRIEKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F4</accession>
    <name>I4Y9F4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959385.1">
        <property type="nucleotide sequence ID" value="XM_006959323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F4"/>
    <dbReference type="GeneID" id="18474221"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60877"/>
    <dbReference type="HOGENOM" id="CLU_2851431_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9F4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="65" mass="7060" checksum="7A4F0D4798B432A5" modified="2012-09-05" version="1">MTTVVSISQQSILLSAGLKFSVLVLPSALPLRTYSNTTFTLHTLTAPKTPGPHILKYSSYLCTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9T4</accession>
    <name>I4Y9T4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_69643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959258.1">
        <property type="nucleotide sequence ID" value="XM_006959196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9T4"/>
    <dbReference type="FunCoup" id="I4Y9T4">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9T4"/>
    <dbReference type="GeneID" id="18475617"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69643"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y9T4"/>
    <dbReference type="OMA" id="RMVAMHA"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="324"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="431"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="572" mass="64749" checksum="4746EA61898BC599" modified="2012-09-05" version="1">MGQLLTIYFTSNQTKKFKKLELIDLFGYQSFILSLQSLFNQIHSNNSYLGAKPDIDKPDDFKSFLIYDQQDSVDSSTPTDISDENFLEYLHSPDNSILKPASPNLHHSIHDYYISASHNTYLFGNQLSGASSTIGYIRSLLLGCRSVEIDVWNGDDGNPIVYHGHTLTQPIPFVEILTTVKNFAFVASNLPLILSVETHCDVQQQDKMAHLLINILGDSLITQKLQHDPSSLPSPEQLRNKILFKTKNRLLNKEKSISYDDYFTSSENSSSSDLEKRSFSNFIQKVTRRASASSDRSSNSSAGSPRFVDSIGNIPSNNRMSQKLLDLLIYTVGVKFRGFNKKEHYNIEHIFSLSDRSARKCINTSSAEFIKHNRNHLTRIYPHGARVKSTNFDALDYWAVGCQLIALNYQTVDLAMWFNFAMFNGNQGFVLKPSPLLHKDEKKLLDVITPVNVTFRVICGQQLPKDINQVSVEIYTPRSFNNAPLKQSTKTSTEAINPVWNDVLSFSVNVRASMTELVVVKFNLHNSQSEDIIASYAITLANIRQGYRNVPLHDAQLNKIIFSKLFVYNSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9T7</accession>
    <name>I4Y9T7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959260.1">
        <property type="nucleotide sequence ID" value="XM_006959198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9T7"/>
    <dbReference type="FunCoup" id="I4Y9T7">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9T7"/>
    <dbReference type="GeneID" id="18475618"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69646"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9T7"/>
    <dbReference type="OMA" id="DRIVECT"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="235"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="323"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="420"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="512"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="601"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122190" checksum="7C3769CA13094916" modified="2012-09-05" version="1">MVKRKSEASDTTSVLKSASTKKHKTFDNAGDSSIGAEVDFPRGGGTGLTAVETAQAKHEGRKEADRDAKLKKKPSVKKQKKTKESSSDKKEKKDIIRVEHLNYRRALPGLKVLCQIVHITAIDLIVSLPEQLLAHIPITNISTHFTQRLDSAMNDDSDDGKSVSDDGNEDLPELDELFQVGQWLRATVLHVHKDSNTGRVKKEGEEIIKASRKLELSIDPRSVNDGLTQKDLEKDFTIVGAVRSVEDHGYLVDLGVPDVDGFVSTTEMDASGFDKELAGQVGSILPLTVTSKSNKVVNLSPNPSTFAKSYMNEANTLESVIPGVVLNAMVTAVLPAGLNVKFFGFFDGTISKEHIPYEKKSLSERFPVGKKVKARVIFDHPTSNPKRFSLSLLPHIVNLQNSLTEKSEDGLTIAEAFGKGRIIEGVQVITVESEKGLYVTIPDSELLGFVHISQIADDHTPSLSSSSGATKVGSLHTARVVGLSYVDKIVQLSIKPSVLEKSFMKVSDAEVGAIVDGIVKKIADDRMFISISGNVDAIVWPTHYSDVKLKHPEKKYRSDMKVKARILTAEADKNRVTATLKKSLVKSDLPIITSYDASNKNVITYATVSGIKEKGAIVDFYNNVRAFLPVGEISESYTKHAKDALEVGQIVKVIIVKVEAEAKRMMASIRKTVPKEEREALIKERKAEQKDKSPAVVDEEDEEDVNAETMQIDGEIASKDDSESEDGSVQGLEIDEESSEEEEDEDEDEVTIDTTNKKPKMSTKEAKALDIGGFNWDGDDNDDEKKSNGSDEEDEDSDAESTNNDDGKRKKKRKGTKHFEGDLTALMNEKPPESSNDFERLLLGSPNSSYVWIQYMSFQLKLSEIDKAREIAKRALKTIGFRESQEKFNIWIALLNLENTFGDDDSFEEVFKDATSYNDPLTMHLKVADILEASEKFDKASDVYVKSSKKFGAEVIFWVNYAEYNFRIGNQTAARSLLTRSLQSLEKRDHISCISKFAQMEFRLGDAERGKTIFEGIVESHPKQLDQWFIYVDMLSRKEDLGGLRNVFERLLSHKLSTKKAKSVFKKWLTIEKELGDESGIDDVKQRAVAWNEQRHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U9</accession>
    <name>I4Y9U9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_20007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959173.1">
        <property type="nucleotide sequence ID" value="XM_006959111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U9"/>
    <dbReference type="FunCoup" id="I4Y9U9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9U9"/>
    <dbReference type="GeneID" id="18470819"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20007"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y9U9"/>
    <dbReference type="OMA" id="EPWQQDN"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="304" mass="34720" checksum="DBA7D88C66814778" modified="2012-09-05" version="1">MRRRATKEEVNKKSTKPNGLLTYNDIPEWMKDNNFITHGYRPVSHSVKQSLRSIFNSIHNESLNIHSHLWGAIFFLLALVAISTDTFHRKHPNYGWKDYLGFTIFILSAITCLSFSFLYHTFSNHSKEFANTWHALDYAGICILIAGSFVPCLYYGFYCSPAFQIFYIASMLIASSVALYIVLHPHYRRPAFRKARTTVFIALGLSGILPITHAIANDGLGVMRTMALDYVVLSGMMYILGATIYACRFPEAYLSHKFNFSYVGASHQIFHFFVVAAAVCHYLAIRSSQSFYGDPEFDYCHAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA00</accession>
    <name>I4YA00_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_33020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959057.1">
        <property type="nucleotide sequence ID" value="XM_006958995.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YA00">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA00"/>
    <dbReference type="GeneID" id="18471607"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33020"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_9_0_1"/>
    <dbReference type="InParanoid" id="I4YA00"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="61"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1255"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="911"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1583" mass="178941" checksum="CF0EB077AA897C89" modified="2012-09-05" version="1">MSEYSIGVRVWIADKTEGWIGAEVTAHSGDEITFKDERGTEIIKKSSANDLPLLRNPVLLEGTDDLVNLSYLNEPAVLYSIKRRYAQHSIYTYSGIVLIAVNPFAKLSIYGPAIMQAYSTRRRGELEPHIYAIAQDAHASMTRENKNQTMVVSGESGAGKTVSARHIMQYLAFLGQDGTGSASTGTDASILATNPVMEAFGNAKTIRNNNSSRFGRYLKILFDKQCNIIGAQTSIYLLERSRLIFQPEGERNYHIFHQLCAGVPPKERAELHLGSSNDFHYLNQGGSASIPGIDDGAEFEVTQKALSTLGIGVEKQWNIFKLLASLLHLGNVKIGQTRNDAVLNEDDEAFKIATEFLGINPSDFKKWTVKKQITTRGESIVSSLNAAQASVVRDSVAKYIYACLFDWLVAVLNEALYKESDASKFNSFIGVLDIYGFEHFKRNSFEQFCINYANEKLQQEFNAHVFKLEQDEYIKEQIRWEFISFSDNRPTIDMIEGKLGILSLLDEESRMPSGTDQNFLEKLHSQLGKPQYKDIYKKPRFGNTAFTVAHYAHDVAYEAEGFLEKNRDTVPDEHLQLLGSSSNSFLREVIEIAVASNAAATPASSTASNNVGVGRRQNLKKPTLGSIFKGSLISLMDTINDTNAHYIRCIKPNEQKKAWDIDSQQVLSQLRACGVLETIKISSAGYPTRWSFAEFTDRYYPLVGSEHWLGDMKELCLQILQVNISDEDKYQIGLSKIFFRAGMLAYLEKLRADRLNTLVTLIQKNILRYLHVKHYKKLREATVSIQTWWRKILAIRYVENLRRDTIIFRLQSAGRRKLAVAKFQNIRRSVIMTQAQIRGMQARVGFADFKYRSSALNLQRIARGVLARRQHETSLRGVIHLQACYRRRLARKEFKQLKSEARSVAHIQEVSYKLENKVVELTQNLQKTREEKKELTRRCNQLEKQMGNMQTRHDDADQRMKEMMVELAKPTVALTDFNELEALKRDLQTQVSTLKIDIQERDKQIQQHKDELGTQAQEIESKSAQAAEASARAADETLVNQLKAEIGSLKDQLHRANTLNALEHGSTKAKQITAPTFSMHLGKSNENVAALVNGAGSPVEGDASDALEALGLPPNKRRQRRHSANGAFLEQNGLGRDTSDEAFAAGKRSEAAPRAVSLAYPTTDNASKLRGLNGRAYFPEVLDDPSEEMIKLLEDEQSIDDDILTTMIHELKAPPPSLQNPPSAKEVLFPAHIMSLVTNEMWKYCLIMESERLLANVMQTIQQHVMSFQGEDAIVPGLFWLSNVHEVWSFVCVTEDDMLQGIVPGGDDPDRPLDWPAYEQLITVVKHDLESLEYNIYFAFMEETKKKLRKMIVPALIESQSLPGFITSDTGGRLFNRLLQGNSQPAYNMDDILNLLNKVWKCLKSYRLDEPVVLQVMTELLRLIGNVGFNDLLMRRNFNSWKRAMQIQYNLTRLEEWCKSHDLPEGCLHLEYMMQATKLLQLKKATTQDMEIIFDVCWILSPSQLHKLITGYMIADYESPLSPHVLQTVSARLSSDRNDHLLLAEEEGSNFELPQPRQVIGLDLYIPGTVSVPHLRRIAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA82</accession>
    <name>I4YA82_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_33074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959134.1">
        <property type="nucleotide sequence ID" value="XM_006959072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA82"/>
    <dbReference type="GeneID" id="18471617"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33074"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA82"/>
    <dbReference type="OMA" id="HSTHPPA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17558" checksum="D18ABA78CDAE5DBB" modified="2012-09-05" version="1">MRCRMRERYTAPLKIEASKLSALKSNTSKISAGKLTAAKTAKILNELPRATRCLATQLRTGHFPTTKSYRYRFKLIDSPKCRTCDTDDNISHRIFICRRHIMARITLRRKITKINIRFELGPMLRNAQALQALYEFFKPQLTTYPRYSGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAB2</accession>
    <name>I4YAB2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959163.1">
        <property type="nucleotide sequence ID" value="XM_006959101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAB2"/>
    <dbReference type="GeneID" id="18474154"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60771"/>
    <dbReference type="HOGENOM" id="CLU_994665_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAB2"/>
    <dbReference type="OMA" id="SEFCVAR"/>
    <dbReference type="OrthoDB" id="3361818at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="285" mass="32477" checksum="5384F4C662F3242B" modified="2012-09-05" version="1">MTDLKKILTPNAVFAVAKRTWGYDMDFYSGSSVRTAIANKQPRLLSADIPIYSSRVTIYQNTNADTLYANPVEYPNEKEDDDDKNTLVDDDASLAGKDAFDKDDLDDKSVLEDDTQPVFEMNGKHAVTTAYRSKYMRSKYTVEVIGYDKPVTLERGSHYLSIKKKFELGDVQYMVFGKKNTISIKNVKTDDVICTFDIPRMSKRKAGVLRLSMSGESSLYERLAVLSVMIVLSSSMNCCMLAGRVRFMLVYKMVWQRQRHPKINTRASALTLVHRTIQTYIKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAE0</accession>
    <name>I4YAE0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_29151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958927.1">
        <property type="nucleotide sequence ID" value="XM_006958865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAE0"/>
    <dbReference type="STRING" id="671144.I4YAE0"/>
    <dbReference type="GeneID" id="18471081"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29151"/>
    <dbReference type="eggNOG" id="ENOG502S8CH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774344_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAE0"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="423" mass="47493" checksum="6BBA62A72C7B7C4C" modified="2012-09-05" version="1">MSHSSNNTRLVELRVLNGSLSIDQLLNILDKSQLELPCNIWYPIKERNDKNEFTIFWLEFSQHQSAIDALKLNIKNFLSLKLTKEIDFKKKLSVHSINLDSVYPKTWICDHCAFQNSYALSFCPRCLLPRDKEDSVTPPSSTSATSTNINQHSPTGPPVGSLFNPLILGQNDNPIQKPAMNSHSVISPELANIPLPSSQISISPISISPTQRSPPQNLFDVLASLPKHTPNQYTQKVNSKNPEPLQDLETLSKSPQSPKSQLPPILNTGSQGPMQMQPGDWICSCGFVNWRRRKYCYKCFPFANGNNSEELQKAAQKAAQLASLPENFGNNSNFENHNLNMSQEVLENKIDKPSINFFTNVQSHPGSVDHHSPITKSKYKASSASKNAWGNDIYNVHQHGLIEGMPHNDETFNEIKEIFYNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAH0</accession>
    <name>I4YAH0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF300-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958955.1">
        <property type="nucleotide sequence ID" value="XM_006958893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAH0"/>
    <dbReference type="FunCoup" id="I4YAH0">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAH0"/>
    <dbReference type="GeneID" id="18471593"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32951"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_4_1_1"/>
    <dbReference type="InParanoid" id="I4YAH0"/>
    <dbReference type="OMA" id="AFAIAHW"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="533" mass="60590" checksum="7BFFFED04F221953" modified="2012-09-05" version="1">MSGGSGSQLPGVLLFLSSLSALVATAISFVGIRTHLGNYRMPLLQRFTVRILVMVPVYSLASLISLFSLDAAYWIDVGRDLYEAFVIYCFFNLLVEYLGGERQLIISLMGRQSTAHMMPVSLFQESMDVSDPYSFLFLKRGILQYAWVKPLLAILTLVLKLTGKYDDGLIAWNTGYTYVQLIYNASICTALYCLAMFWVTVNDDLKAFRPVPKFLSVKGILFATFWQGLLVSFLVAIGAISKLGPYTDPEHISLAIGDILICFEMPFFALLHLFAFSSDDYIPKKTYHSSRLPLGYAFRDSFSMKDVFIDSIQTLKGVGFDYKEFEPVAANKIHQGKARDRRLGAGLRYSERGTQKYWVGGTNGEGTSRQVNYNSIDNSNTPIQAHMNRRYNFIDDLVKLEFDDISNAEERLYTESRRLPYGDYNYPNIDVSREEETRLRRDIENQVLANKSSAASRLLSPNQSRDIDAEQRGREGVRTRKSLSNINESIPNIEVNEEHEDDNEDDDNENDTTIAQNHPESYSFSYREPNPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ6</accession>
    <name>I4YAZ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_54722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958812.1">
        <property type="nucleotide sequence ID" value="XM_006958750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ6"/>
    <dbReference type="GeneID" id="18472689"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54722"/>
    <dbReference type="eggNOG" id="ENOG502S0ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062487_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAZ6"/>
    <dbReference type="OMA" id="TTVWCEL"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28828" checksum="C3A064B2FFAE0B00" modified="2012-09-05" version="1">MANVDEESQTPTPSPRPEKRSLSDFLNEEVEHNNSTIPLAWQSFLTGFIDLILYSRSQVWVGFQTGNMVQFSGNIAQYMLPDYIREPLLTLERVISICAFFLGSFMSARLANYFGGRTRKSLFISSVIQSCFLWGASAILLTRPEDELPTFRYFPAVLALAAWSMGMQSGASQKLTSPAFATTVAFTATLSQIASDPNIFKLRSAARDTRMIGIVSLCIGAGVGEMFLYAKTNLRGGLAVVAGFKLLQAFMWFLPKASQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB51</accession>
    <name>I4YB51_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_32902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958865.1">
        <property type="nucleotide sequence ID" value="XM_006958803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB51"/>
    <dbReference type="FunCoup" id="I4YB51">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB51"/>
    <dbReference type="MEROPS" id="M24.017"/>
    <dbReference type="GeneID" id="18471581"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32902"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="InParanoid" id="I4YB51"/>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="45029" checksum="95A3BBA24A62E8DA" modified="2012-09-05" version="1">MSKCAGVECQQANAKMQCPKCKDLNISSFFCGQDCFRKSWSVHKATHTQANDVNMMKLAAALRQSGSAIGAGEPLEDGAYDPFPNHPYTGKLRPHYPLSPKSIVPDSITKPDYAKDGNPRGEIRLAKGLATIKRLSPEEIDTMRRVCRLGRYILDKTAQQIKPGVTSDALDKYMHKLAIENGSYPSPLNYHGFPKSVCISVNEVICHGIPDKRKFKEGDIVNLDISVYKDGFHTDLNATYPVGSVDDASKKLIEVTRRSLDNAIKICKPGTPFRNIGSQIQPTCDKEGFSVVKTYTGHGVGREFHQAPTILHHENMRSKGEMKPGQIFTIEPMVNASKSYHVDHWNDNWTAVTRDGVRSAQFEETILITEDGCEVLTAADDYVPPAEHVKIPTIKSDQDVISIQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB58</accession>
    <name>I4YB58_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_38999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958872.1">
        <property type="nucleotide sequence ID" value="XM_006958810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB58"/>
    <dbReference type="FunCoup" id="I4YB58">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB58"/>
    <dbReference type="GeneID" id="18472093"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38999"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_3_1"/>
    <dbReference type="InParanoid" id="I4YB58"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="34311" checksum="E75A4B126B5DE43C" modified="2012-09-05" version="1">MATTEQDPTLREMAAMEIESCQKSQEDALNELVNGLLRSNTPAEITPKGLILELKAGVGGSESGLFVQDMLKMYKAYSETRGWKSEVIATIMANESSGGAGAVKEALVEIKGPNVWSTLKYEKGVHRVQRVPLTETQGRVHTSTIGILVMPLAENNQRKVYDEKDVRVEVMRARGAGGQHVNKTESAVRLTHIPTGIQVSMQDTRSQQQNRTKAYEVLASRLLERQIREEVEERKTSRKSQIGNMDRSDKIRTYNFPQDRITDHRVGVGLNDIQSFFENGEGLDWIIDSLKEREKELLLDGLLQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBE0</accession>
    <name>I4YBE0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4E binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_69144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958635.1">
        <property type="nucleotide sequence ID" value="XM_006958573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBE0"/>
    <dbReference type="STRING" id="671144.I4YBE0"/>
    <dbReference type="GeneID" id="18475533"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69144"/>
    <dbReference type="eggNOG" id="ENOG502S44S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111706_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBE0"/>
    <dbReference type="OMA" id="KQAKSCP"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF12">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9859" checksum="D9F487661E0FD34C" modified="2012-09-05" version="1">MDIPKQASRLNLSKTPTGNNFYGSTPGGTKIVYSRDQLLSLASSPLSHTPPKGLSHFPAAMSRSEHKPVELAQPGKEATKTNEDTTFEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ6</accession>
    <name>I4YBQ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_18922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EIM21398.1"/>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
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        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="263"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="538" mass="61068" checksum="AD2CCB9F8F216B24" modified="2012-09-05" version="1">MDDREQNNQLSTTPISIKSLSNNNLLSTPPTPSSANNSFDYVDHSIDDIFNQFYKLNHNDKLLALNKILPSLTIPQVIHANNLLAPRLKRDFLKELPLELSLHILSYINHPKTLARCSQVSKWWRDIVEDENNWKDMCFKHRYKPSNSSFQQRVAFYRANSIVRRNSLDLNNDHSFWTSQQSTQDFSYKKHFKHSYLTESNWRKGGRLISSHVSPEDAVVTSLVMDDNFIIIGMSNSNIHIFDALTGRWKCALQGHVQGVWCWGQNGTIVVSGSCDRHVRVWDAESGLCLHTLSGHTSTIRCVKVVPGKPIAVSGSRDATLRVWNIENGNLIHVLQGHQHSVRSIDVSGDKIVSGSYDCTSKLWDLNTGECLHTFEGHAHQIYSIAFNGELIATGSMDNTVRIWSASQRKCLAMLQGHTALIGTLQLTDNILVTGGSDGRVIVFNLDNYECLHRIDAHSNSVTSLQFDERFIVSAGNDGRIKLWDFETGKRIRDLSERGESIWRLAFTEEKCVILSRRNEKTVMELFTYLPLDDEVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ1</accession>
    <name>I4YBZ1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_38453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958512.1">
        <property type="nucleotide sequence ID" value="XM_006958450.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="I4YBZ1">
        <property type="interactions" value="329"/>
    </dbReference>
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    <dbReference type="GeneID" id="18472065"/>
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    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
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    <dbReference type="OMA" id="CHAANQS"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="6"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="891"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="945" mass="105866" checksum="79164B6C83E2E24D" modified="2012-09-05" version="1">MADQSPMILAQAKTTDDVDFNHGIKSTIANVYGEDPSNYSDPVAALNRYRQDATRGATTDATGRDLLQSYYGQLEMLELRFPELRVMFNWRDVFTAQEISQHSLAYEKASILFNLAATYSVLGSSSNRTDPEGIKKAFYNTRVAAGLWDYIANNFLHAPSTDLSRDVVRFLSALMLAQAQEIFLEKTIEEKTRNGNVDGKSMGIVAKLASQCSFQYNALIEPVRENVNKGIFDRHWASVIHIKTKYFSSQTQYFRAMVDKAAGKHGESIARINLAESLAKEAYRLGATFNTFFAPCDTLPADVSSILTTLCKSHQTKCAEYKDEIVKENDLIFHEPIPAENVLAVVEKLNAANAVTITDIYQNPEVQRSIGADLFASLVPFSVHEAASIYSEEKAKIIRSVTEKVEIADTELEAAIEYLGLPGSLRKFVSPSNNINYDISSEVKELSRVIETQEASGGLTKKLSSIASKRDQITSDLQWISNELDIESKECEQARMKYPDFSQSPSARHTKEWRQQLKAHNSGLEKAGSSDASIKQVYQYIDDDVRLLADSAADIEDDDSELALVVRDYVLHLRPSDSRQESLLDVDVGVEESTEVESQQMQAHAREIARLLELLKGLKKQRSQHIQVLRQKIQNDDVSHLLILNRKAQQVESDMFGSELEKFKDDQKMIDNSISEQLKRLEELNGSWLRLTSTTRAKDIHNKHSESDRRRKEILKKFKKAGDTYFEAADGVNRATVFYDDLEQVVNQLKKDVGSFVNKRAKERVQAIVDAEAGSRNSGGIASSFESEFGRINLQTPHRPPKPGVSPPPATSPSPSYAYGGLPPPPAQPQPSIYQSLYGQQTQAPPQMQPPPPKPSSPQYVGPGYSAPPQSPPYPQQTPSPYNVPQPPNPSQSHMLYQQSQSPYGPSQNAYQMPPQTYQQPSQQQPQQQYYQQPPAPPQNYPYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC54</accession>
    <name>I4YC54_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_38557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958568.1">
        <property type="nucleotide sequence ID" value="XM_006958506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC54"/>
    <dbReference type="FunCoup" id="I4YC54">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC54"/>
    <dbReference type="GeneID" id="18472072"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38557"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="InParanoid" id="I4YC54"/>
    <dbReference type="OMA" id="ICALSMC"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="340" mass="38392" checksum="242352607CFE5B01" modified="2012-09-05" version="1">MSKEELPQNKKREQIVEHVLLIGTGAIGILHGYLLEKSGKIKVTAICRSNYDTMKDSGITIKSSSFGSCIWRPHRVMRSIEEASDREYNYAVCAFKCLPDVIPTERVLGEVLTRVKCVVLLQNGVGIERSLQMARPDIPIISGIVWVGVNIRDNILVHEDFEKLYIGIYKNVHGRNNAELVNHFAELMGREQEYVIVKEHIQQSRWHKLLWNATFNTLATLSGLPMRRLMRGVGVLPIAKSIMDEIAATAAAIGIDLPEETISDSLDMTMKYYGDIGDDKSEEDFKPSMLIDYEMNRPMEIECILGEVVRMAGMYRVPVPHIELAYFILKIKQVSLVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC95</accession>
    <name>I4YC95_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isocitrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958284.1">
        <property type="nucleotide sequence ID" value="XM_006958222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC95"/>
    <dbReference type="FunCoup" id="I4YC95">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC95"/>
    <dbReference type="GeneID" id="18473893"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60334"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="I4YC95"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="39195" checksum="4FF9917B49C384FC" modified="2012-09-05" version="1">MASAAKNLATKTLRFGMLPADGIGHEVLPPAQRVLEELSTRKALPKLEFIPLNAGFDYFRRSGVALPDETIEVMKSGVDGAMFGSVSSPSHKVTGYSSPIVALRKHLDLYANIRPVSTVDGKVDMVTVRENTECLYIKKEELDRLPDGTKVARATRQITQNASERIGKLAFEIALKRDKVRQSGGSSPHSEPSVWSIHKSNVLSVTDGLFRESIKAAHKSDERFDKVKLVEQLVDSFVYRMFREPQIFDVCVAPNLYGDIISDGAAALVGSLGVVPSINANDTFAMGEPVHGSAPDIAGKNIANPIASIRSAALMIEHMGYSDAAASIYKAVDEVLKEGKMLTPDLGGKSSTTDVQDAVLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD6</accession>
    <name>I4YCD6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958323.1">
        <property type="nucleotide sequence ID" value="XM_006958261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD6"/>
    <dbReference type="FunCoup" id="I4YCD6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCD6"/>
    <dbReference type="GeneID" id="18473906"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60353"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCD6"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="127" mass="14224" checksum="B92F9D6C2B0D25AE" modified="2012-09-05" version="1">MSTQPLLQRTSNKRIALPVRVEPKVFFANERTFLSWLHFAVILGGLAIGLLNFGDKVGKISAGMFSFVAMLIMVYALVTYHWRASAIRKRGTGPYDDRLGPTILCICLLSAVLINFYLRFAQGEDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG4</accession>
    <name>I4YCG4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958347.1">
        <property type="nucleotide sequence ID" value="XM_006958285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG4"/>
    <dbReference type="FunCoup" id="I4YCG4">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCG4"/>
    <dbReference type="GeneID" id="18473913"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60362"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021740_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCG4"/>
    <dbReference type="OMA" id="YTCSPDD"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="242"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="34200" checksum="D50CA1F7E226B4A5" modified="2012-09-05" version="1">MIVFDTRLQVIKALNALVQNGVVSAPLWSSVESKFAGMLTISDLVHLMQYYYSTTNSYEGAADDVEQLTLGNLRDIETAIEVLPPPLHSIHPMRPLLEACHILMTSHARRLPLIDHDDRTDVEVVLSVLTQYRVLKFIAVNCKETLGLQKTLLELNIGTYATAESIQDTSFEPVSTATMDTTVFDVVHQFSAKGISAVPIIDEEGVVINLYETVDVITLVRLGSYQSLDLTISSALSQRSPEFPGVITCSPKETLANVFSLIAKRRVHRLVMVEDEDKQLPNGTIRKKGALVGIVALSDILKHVIGFNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCQ7</accession>
    <name>I4YCQ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_18221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958028.1">
        <property type="nucleotide sequence ID" value="XM_006957966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCQ7"/>
    <dbReference type="STRING" id="671144.I4YCQ7"/>
    <dbReference type="GeneID" id="18470755"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18221"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144565_1_2_1"/>
    <dbReference type="InParanoid" id="I4YCQ7"/>
    <dbReference type="OMA" id="RIVNECQ"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="131" mass="15203" checksum="D6984EA1028C8EDF" modified="2012-09-05" version="1" fragment="single">MDDDLLKPTKRPLDHTPLQSNKKSKQGASSSFVPKLFQMVNSNTNNLITWNLAGNSFIVANLGQFSRDILPNHFKHSNFSSFVRQLNMYGFHKCNKTPRGQKSHPDHQVWEFSHPKFLKDRPELLDDIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV3</accession>
    <name>I4YCV3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_54373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958099.1">
        <property type="nucleotide sequence ID" value="XM_006958037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV3"/>
    <dbReference type="STRING" id="671144.I4YCV3"/>
    <dbReference type="GeneID" id="18472667"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54373"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027074_7_0_1"/>
    <dbReference type="InParanoid" id="I4YCV3"/>
    <dbReference type="OMA" id="EWRYEMR"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="218" mass="24807" checksum="72AEAA94D0A33837" modified="2012-09-05" version="1">MEIDNEEVNHTRVLLENSDGFDGGSDWRYEMRRECQEIIPNLVLGPYQCSKDTAFLTSAGITHIVVIRGEAEAVFVRPRYPDQFSYLVLDVRDSEEQNLIRIYPEAREYISNALQNGGKVLIVCNGGISRGPAITIMYVMEAAQVSFEDATNYVQNKRYCISPNLGFQCQLKEFEAIYRASLAIANQPTLTRDSKRRLEDDDSIEADIDARPSRNQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB7</accession>
    <name>I4YDB7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_63708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957771.1">
        <property type="nucleotide sequence ID" value="XM_006957709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB7"/>
    <dbReference type="FunCoup" id="I4YDB7">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDB7"/>
    <dbReference type="GeneID" id="18474862"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63708"/>
    <dbReference type="eggNOG" id="KOG1351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_3_0_1"/>
    <dbReference type="InParanoid" id="I4YDB7"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="157"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="390"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="517" mass="57727" checksum="B5861BD62FEDAAC6" modified="2012-09-05" version="1">MSDPRISSKEAFDLNAKAATKEYQVEPRLDYRTVSAINGPLVILDNVKLGQYNEIVQLTLPDGSKRRGQVLEVSGKKAVVQVFEGTSGVDTRDTHIEFTGSSMKLPVSEDMLGRIFNGSGQPIDNGPKVFAEDYLDINGSPINPYSRIYPEEMIQTGISTIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKGPSKGIHDDHEDNFSIVFAAMGVNMETARFFKQDFEENGSLDRVTLFLNLANDPTIERIITPRLALTTAEYFAYQCEKHVLTILTDMSSYADALREVSAAREEVPGRRGYPGFMYTDLASIYERAGRVEGRNGSITQIPILTMPNNDITHPIPDLTGYITEGQVFIDQQLNNKQIYPPINVLPSLSRLMKSAIGEKLTRKDHGDVSNQLYAKYAIGRDAAAMKAVVGEESLSGEDKLALDFLDKFERQFVNQGPYESRTIFESLDLAWDLLRTFPKEQLNRISPKIIKEFYEKRKEEAEDDNKHKGVVDSVKDENLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE4</accession>
    <name>I4YDE4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hal4</name>
        <name evidence="14" type="ORF">WALSEDRAFT_60116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957796.1">
        <property type="nucleotide sequence ID" value="XM_006957734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE4"/>
    <dbReference type="FunCoup" id="I4YDE4">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDE4"/>
    <dbReference type="GeneID" id="18473753"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60116"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_127_2_1"/>
    <dbReference type="InParanoid" id="I4YDE4"/>
    <dbReference type="OMA" id="VIYMFMR"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="109"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="394" mass="45036" checksum="C8A5B5D8718314EE" modified="2012-09-05" version="1">MASQPQPDKKPSKFIKLFEKKEQSQSPTTSEHSQLASRPPSRQQSQKGSREQPKRSNSETHSDSGGKLTHALLDLLPAPLNRKSSASSHNNKDKDDHNSNTSLNKKYGVCDKVAIGRGATAVVRLAHRWDRSDEKLFAVKEFRKRRKNETEKEYVKKLTSEFCISSTLHHNNIIETVDLVKDENSHWCEVMEYCPGGDLYAAIKKGQLGEKLSIAFFKQILLGINYLHSMGVAHRDIKPENLLLDGRGSIKITDFGVSDVFRMCWEKKTHMSKGLCGSEPYIAPELFEQKEYDARLVDVWSAAIVFYCMTNQELPWRVARLADPTFSQYEQSWKRPPRLTELHPIKEFPTESHQLILKMLAPNPKDRCLIDEVLKDSWIKSIKTHQHGHSDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDI4</accession>
    <name>I4YDI4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_54234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957834.1">
        <property type="nucleotide sequence ID" value="XM_006957772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDI4"/>
    <dbReference type="FunCoup" id="I4YDI4">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDI4"/>
    <dbReference type="GeneID" id="18472659"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54234"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDI4"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="238" mass="27083" checksum="5D91A1E7B58DE531" modified="2012-09-05" version="1">MNIIESLFGRAITPQERLRRHQRALQKAQRELDRERTKLESQESKLVSDIKRSAKNGQMGPTKLMAKDLVRTRKYIQKFYQMRTQLQAVSLRIQTLRSNQQMSEAMRGATKSMAMMNRSLNLPQITRIMNEFERESSSMDMKEEMMSDAVDDVMEDDQGEEEEEKIVGQVLDEIGVTLNQQLADTPDTLAQTSQKQPDKLPLAEGLPSGPSGGSNNPAPADKTDEDSLQARLDRLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL0</accession>
    <name>I4YDL0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957856.1">
        <property type="nucleotide sequence ID" value="XM_006957794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL0"/>
    <dbReference type="FunCoup" id="I4YDL0">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDL0"/>
    <dbReference type="GeneID" id="18473773"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60149"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDL0"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="157" mass="18313" checksum="8A0C078779E01C24" modified="2012-09-05" version="1">MMNYVLLVSRQGKVRLAKWFMATQPKVKAKIIKDVTQLVLSRRTRMCNFLEYKDSKVVYRRYASLFFVCGISQGENELIALEVIHRYVEVLDRYFGNVCELDLIFNFQKAYSILDELIIGGEMQESSKKNVLRNVAQADNIQDNEESEESITSLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDM5</accession>
    <name>I4YDM5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957871.1">
        <property type="nucleotide sequence ID" value="XM_006957809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDM5"/>
    <dbReference type="STRING" id="671144.I4YDM5"/>
    <dbReference type="GeneID" id="18475421"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68546"/>
    <dbReference type="eggNOG" id="ENOG502S8AZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517005_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDM5"/>
    <dbReference type="OMA" id="LYIDMKR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF356">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60176" checksum="0AE14720B59FD71E" modified="2012-09-05" version="1">MLGLFRQTVVLSTKRIPRRAPRKPTYDGTGKLQSTDSYLLAARVKELSQKKKFNEAYAVVQNESRGNGLANVVVWNQLLQESRINQKPSDTYKLFMEMKKRGITPNSRSYTIVFRALSGVDKERPTKKVIEAAETIFRQFGIYQQSLDDEIDRNLVEEERSVLPINAYLSILSKVAHSKDMMDVFEDMADIGPSSADTYTYTTLFQGLLKAGQREDVERGLTLWKVYMDRLKDAWKHSKDTPECQRLLPDTALISTVLRLLSKGTPKDCKTGLMIAHIFLGVPSHSPFIEKKELNIPKVELNDRIIDSLYHLGLAAERPSLVIRHADFLLAMDSVKKYISTRSMFFALLACAQEGNSDKAIEYLHMMCTELRRAQPDSQSFDQAMSAAMKARSYKHAKEIYEMAISTKTEVDIRIMSSFIKAALSTGNTGHIFDAMEIFSKYGITRFIKSEDKEQSRTTNKHQRFWEHRLATGLRDALDKLKTQNVPGRTRKHNLLFGEYARVIAGIIGEKKVVNSRNTYDEWDIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDT8</accession>
    <name>I4YDT8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_51116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957932.1">
        <property type="nucleotide sequence ID" value="XM_006957870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDT8"/>
    <dbReference type="FunCoup" id="I4YDT8">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDT8"/>
    <dbReference type="GeneID" id="18472545"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51116"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDT8"/>
    <dbReference type="OMA" id="WIFGYGE"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="24545" checksum="C8CE51B155AB48DB" modified="2012-09-05" version="1">MNLLVFGYGSLLYKPVPHYIGRYPGYIKGFARRFAQSSNDHRGTPASPGRVATIIHSDEWQDYAKSHPCGAQDAFPEDDQVWGVVYEIAQEHSFAVKAYLDHREKNGYAEERLDVYGPDNKIKFRDVLIYVGRLDNPAFVGPEPLKELAMRIATHAGPSGTNKDYLYQLAEHVRLICPESTDHYLETLTAKVKEFEQAAIIDQLRRSKATDVTLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY6</accession>
    <name>I4YDY6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957975.1">
        <property type="nucleotide sequence ID" value="XM_006957913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY6"/>
    <dbReference type="FunCoup" id="I4YDY6">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDY6"/>
    <dbReference type="GeneID" id="18471461"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32302"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_5_0_1"/>
    <dbReference type="InParanoid" id="I4YDY6"/>
    <dbReference type="OMA" id="LLNWECC"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="68"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="23895" checksum="3B8AF38C9ECBA766" modified="2012-09-05" version="1">MFARSFIRQTGRQATRAFSTARASNNSLRNVAFGVGAAAALGATALATKPVHLDAPQSTIAGTEGTFSERSFVMIKPDGVSRQIVGKIISRFEERGYKLVAVKTVTPSKELAKEHYIDLAARPFYPGLVEYITSGTPVVALVWEGKDVIRQGRRMVGATNPLQSDPGSIRGTYAVSVGRNIIHASDSFESATKEIGLWFNEKELSNYQPIAWPWIFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE10</accession>
    <name>I4YE10_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957997.1">
        <property type="nucleotide sequence ID" value="XM_006957935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE10"/>
    <dbReference type="GeneID" id="18472891"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57238"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
    <dbReference type="InParanoid" id="I4YE10"/>
    <dbReference type="OMA" id="FQEYAIV"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="32"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="339" mass="37224" checksum="6642B8EB56CA497B" modified="2012-09-05" version="1" fragment="single">MHITENRDALVNVEDANSASKALIIESKHTYKLTSEWKQPKLNGNPHNVKVRIIAAGLNTIDYKSVDYNFNLPQYPWTLGREASGIVIEAGAEASKTLSVGDRVWVSTYYKYIDGGVFQEYIVVPSHTVIKIPSTITYDKAATLGVTALTASMTLHHYFNISIDANTPDSLLVWGASTVTAQFIIQLAVRSGMNVYGVASETNLKLVESLGAIPISRSNKTYDEIVDEVNAVSNNSIKYVADLIGIESSNAALRLLKRGGVIAPLASMTLGKDAKIPDGVDVKIIEMKRFILDSSYKWHADYLNKLIQANELVFPAIEILNGFESIQTGLDRLKQGNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE31</accession>
    <name>I4YE31_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957488.1">
        <property type="nucleotide sequence ID" value="XM_006957426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE31"/>
    <dbReference type="GeneID" id="18472870"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56918"/>
    <dbReference type="HOGENOM" id="CLU_1321812_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE31"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="23885" checksum="31714657941B0570" modified="2012-09-05" version="1">MLETYYPLIIFLLIFCINLNAMQFQKRIEKLELHCFDNSLTHQKMTNPDYKTQSDYQKSIEQPSLSNNVDLETKRNTPLGSKKWLTPKIMLFCILAITALTNYNVFDNIITRATQKTNAKTCFPQYITLGDNFFFKYELRGSCDAIDAVKQLKDRLYFAVSHIPTEYRRNNAACLKLSYGNYWGYLVTEGAGDSDESAAACDDGAEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE33</accession>
    <name>I4YE33_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957490.1">
        <property type="nucleotide sequence ID" value="XM_006957428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE33"/>
    <dbReference type="GeneID" id="18475365"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68228"/>
    <dbReference type="eggNOG" id="ENOG502SCFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129439_3_0_1"/>
    <dbReference type="InParanoid" id="I4YE33"/>
    <dbReference type="OMA" id="NFWEAPE"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="97" mass="11616" checksum="4C1E3AB8469F14B4" modified="2012-09-05" version="1">MRATRIVLEHVHTPRIRFLGRRVWNSQPEKPQPHPEAPKDFKDNFAQFVQKRQDYVQPSKNNHINFWELPDRFHKHKFAPYSDYEIEAIESGGASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE39</accession>
    <name>I4YE39_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial import translocase, subunit Tom22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957496.1">
        <property type="nucleotide sequence ID" value="XM_006957434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE39"/>
    <dbReference type="FunCoup" id="I4YE39">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE39"/>
    <dbReference type="GeneID" id="18473651"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59958"/>
    <dbReference type="eggNOG" id="KOG4111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094333_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE39"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15225" checksum="1873BD93A930749B" modified="2012-09-05" version="1">MVQIQELKSEDEFTDEEFDSEIEEELDVEDEFDPSDESLADRISALKDIIPLETRNSIKEKFTNSVAFTRKSSKVLGNLIWIVTTSSLLVGLPLALAIEDESRISMEEKSLLAQQSGQQEMLGEESKQQGIVAPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED3</accession>
    <name>I4YED3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_68307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957580.1">
        <property type="nucleotide sequence ID" value="XM_006957518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED3"/>
    <dbReference type="STRING" id="671144.I4YED3"/>
    <dbReference type="GeneID" id="18475376"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68307"/>
    <dbReference type="eggNOG" id="KOG4122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_1_2_1"/>
    <dbReference type="InParanoid" id="I4YED3"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="88" mass="9913" checksum="B7FC93A45CE53FF3" modified="2012-09-05" version="1">MLSRVFSRTTLNALRMHNQRSIQTKSNLLPIVNPTRATAVATPSQSQSQGMKVRSSVKKMCDGCSIVRRKARLYVICSKDPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEE6</accession>
    <name>I4YEE6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="11">PAGM</shortName>
            <ecNumber evidence="4 11">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_60021</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 11"/>
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        <property type="protein sequence ID" value="EIM22338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006957531.1"/>
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        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEE6"/>
    <dbReference type="GeneID" id="18473689"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60021"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEE6"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
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        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
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        <property type="entry name" value="A-D-PHexomutase_C"/>
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        <property type="entry name" value="A-D-PHexomutase_CS"/>
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        <property type="entry name" value="AMG1_II"/>
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        <property type="entry name" value="AMG1_III"/>
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    <dbReference type="PANTHER" id="PTHR45955">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
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    </dbReference>
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        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00408">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="206"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="17">
        <location>
            <begin position="308"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="462"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <begin position="507"/>
            <end position="511"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="516"/>
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        <ligand>
            <name>substrate</name>
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        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM22338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="554" mass="60276" checksum="4FD119177D04444A" modified="2012-09-05" version="1">MSINEQKLQELGSKHPAPPNFKYSYGTAGFRSKASVLDSVLFRVGLIAVFRSQKLDGKAVGVMITASHNPESDNGVKLVDPHGDMLDPSWESYATGLANTPIESLSSYCNQLVNTLKLDTTKPANIIIARDTRPSGLDLLNSLKDGIEALNNGSVQVQDFGLATTPALHYLVRATNSKGTKDDYGEPTIQGYMSKMVQSFLSLVQGKPNIPALKVDCANGIGAPYIKDLINKLNEADAPLTIDAIFDDTTPAIGKLNNGCGADHVKSKQQLPIGFQPEPLERCASLDGDADRVVYYYNDQRGNFKLLDGDKIASLLAVFIIELVEKAGITEEAKVGVVQTAYANGCSSKFINAQQVPIKCVPTGVKHLHHAAQQYSIGVYFEANGHGTVLFSPEFINLVKTTTPTMPAQQTALQQLLSLSELANQTVGDALSDLLLVEAILIQKQWGPAEWDGLYEDFPNRLVKVTVPDRTAFTTTDAERKLVTPNDLQKSIDQHVSKYQDGRSFVRPSGTEDCVRVYAEAQTRGQADELAFKVAGLIYDSQQGDPISRPKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEJ1</accession>
    <name>I4YEJ1_WALMC</name>
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        <recommendedName>
            <fullName evidence="8">EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_37184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006957571.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="18472003"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37184"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281072_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEJ1"/>
    <dbReference type="OMA" id="MSKFTPT"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EH_dom"/>
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    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12763">
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
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    <dbReference type="SMART" id="SM00165">
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1116" mass="121264" checksum="7438A4318EF4B4C1" modified="2012-09-05" version="1">MSFPNLSLSPSERHAFAHFYKLAEKGNGIVSGESAVAFFSYSGLTPLQLGQIWQISDTNNNGFLDQQGFSVALRLIAHLQANETLTEDLINKPGPIPQFDGIPPPAIPQVSSPTNQPSISPIQTQQIPPVQVDERSRFTRIYAGCGPINGLLSGDKARDVFIKSKLPFDVLGQIWNLADTQNRGSLDLTDFIIGMHFIQCYMNKTISQLPSTLPPAVYEQASAGRQRSQSPLVSSPIQNQLTGGSQAGSPPPSRQVRFAAVGANDSPQSISAIPPVQTQPSEPAKITAEEKKSYDGFYDSLNPSGNGVLEADKAVDFFSKSGLPIEILANVWDLADVRKTGSLNKDEFAIAMYLIHGCLAGKPLPSTLPDNLIPSSLRSSAPRKPADDLFDLMGDESDLQPAVVQPQHSGGIQPAGIQPQHSGGIQTAGVQQQGTGLSSQSTGLSSQTTGIQAQPSAFQVPGWQNPPLQQQQAPQQARSPFENPSSYQQPALVDDLLGDSDVQQSKLNTDTEAVQSAKGQLSETDKALSDYQTRRADLETRVNTAETERKDLEQRLTNARKAHDTESKLVSELQVKLTETTAERRRLEQELITAESDCSAQKVERAELETAYMREKEETRVLKAKILEISNHTTEMRQALSEFQETTQASKGENEETKEQLRNAESERDNAAKELKRYSNVDPAETLPTDGEKELDEKLKDIEDSKQEPEVKPETLETPKEDTETAAENVKETPVLAQNDLKEEHKESKEIKETKEDTTIVPTTEAASAVPLPTSPESAQEEPQSVSKALSPSSTKSTNPFDNFSKPVEEAGTTEDPFAVNDTSKSAFDSFDDNFDKLENTNSNVQDNTNIEAPATNFDDAFAGFDSKPTDSKAAFDESFAPAVGTAPAASSADKESASPFDNFAPAVGATLPAVKGKERDNDSSDDDEGPEDLPELSEQPPNLNPKDDKKDEFEDAFSSFPTAPSQADAKNKNPFDAMIGNTGEKKDDHDDFDTSFADLPAAQIAAGNVPGENDDDHDSAFDFVADFDQPGTSNKQAPNKAFDDFSDTFSMRSPTSDQADNTAKPNLPPRAENAEEDDIKQVKQLVNMGFDRPQAVKALEKSGFNVEKALNRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEK8</accession>
    <name>I4YEK8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_37214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957647.1">
        <property type="nucleotide sequence ID" value="XM_006957585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEK8"/>
    <dbReference type="FunCoup" id="I4YEK8">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEK8"/>
    <dbReference type="GeneID" id="18472004"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37214"/>
    <dbReference type="eggNOG" id="KOG0479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_1_1"/>
    <dbReference type="InParanoid" id="I4YEK8"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="261"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="636"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="818" mass="89682" checksum="AACB4CE12FCF3A55" modified="2012-09-05" version="1">MLRQGQQRLIINIDDMRDYRRDYADGLLKTPNDYFPALEEALYEVIKVVHNPDTDDIVNKSFYCGLRGSFGDNHVNPRTLRAMHIGNMISLEGIVTRCSLVRPKMLKSVHYCPETKEFQSREYRDAQMMGNAPVTTSVIPTTDDNNNPLQTEFGFSTFKDQQMISIQEMPERAPAGQLPRSIDVQMYDDMVDKVKPGDRIQLVGVYRAIAGGAGTSATVRTVLLSNNAILLSSKAGGGIAQMMITDSDVRQINKLSKRKNIFNLLSQSLAPSIYGHDYIKKAILLLLLGGQEKNLDNGTHIRGDINILMVGDPSTAKSQMLRFVLNTAPLAIATTGRGSSGVGLTAAVNTDKETGERRLEAGAMVLADRGVVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIYGQYDVHKDPHRNIALPDSLLSRFDLLFIVTDDVDEQKDRMMSEHVLRMHRYLQPGVEEGTPAVDNLDQALDVGTQAEEAIVETQPFEKFNPLLHAGVTTTIGKGANKRKEVLSINFIKKYVQYAKNRITPQLTKTASEYIVDVYAGLRNDDQAANTRRTTPLTARTLETLIRLATGHAKSRLSQTVDEVDAQAAEEILRFALFKEVIKVGKGKTGKTAAGKKKRKLNTGGGAEPSDSEMDEDEEGDGDASEDSDEGDEEGMQQDGQEMQQDGQENDDAQAAAMLDNSMMDTSMNFDNLASTRTTPAPTAPPAPSAPTSVDDALTPQRVALFKTKFADALQSTFDGEEAVSVEDAVQEVNKGLGTDALFGSTEAMKVLERMNDENEIMLSGGIIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW0</accession>
    <name>I4YEW0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_16555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957166.1">
        <property type="nucleotide sequence ID" value="XM_006957104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW0"/>
    <dbReference type="STRING" id="671144.I4YEW0"/>
    <dbReference type="GeneID" id="18470701"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16555"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="I4YEW0"/>
    <dbReference type="OMA" id="WWVHQNF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="530" mass="58607" checksum="07BB6ECF39C286F4" modified="2012-09-05" version="1">MTFIADIVGNYYKVGSGVILGVVLIWLVVKVNTKSPLKNINGPSSDSWLTGHMLKLFDPNGFFYHEQLVDKYGDIFKYKGLAGESSLYVSDPRALQHILFNDGKLFEAPDRSLALSQLLFGPGVSGVRGHQHRKQRRTLNPVFAAGHTKELAPILNSIAGNLEAEVGTQGDVKVDILEHFSHVTLEAIGQCGLGYSFEQEGDAYGEAAGNLIPTLTELRVFIPILPTLIKLGPRVFRKWVVDKLPIASLKKMKSIVNLIYGTSVKIYDRKSKAFKNDSFEAGVPDGSDIMTSIFKANNSAKASNRLERDEILGMITQTSGALSRILEVLSNNKEAQDKLRAEIKNASAADGNFEHDVVQSLPYLEKIIKEVLRLFPPLITMERIATKDTVLPLSRPIHTTDGHHISAIPLKAGTTVMMGLAAANRSKFVWGEDAREFKPDRWDDVEKSEKDKSKSLPGVWSSILTFLGGTRACIGYRFALLEMKVILSHLIQTFEFKEADVNISWRIGAIQSPHTDEKDEPSLPLLLNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF02</accession>
    <name>I4YF02_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_36529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957214.1">
        <property type="nucleotide sequence ID" value="XM_006957152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF02"/>
    <dbReference type="GeneID" id="18471968"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36529"/>
    <dbReference type="eggNOG" id="ENOG502SQ8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611962_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF02"/>
    <dbReference type="OMA" id="HPNTAFN"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697748" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="174" mass="18330" checksum="F76E27370A4A91F7" modified="2012-09-05" version="1">MKLQIISIAAIASLVAALPQGDAFGAPPPPSNTSTTPPTPTGEVGVAIHPNGDTSKCVDVAGASFGNGTPVQIYDCNGTDAQKFVIRKGQTSVKVANRNFCLDAGSNPGSGIKAKIWQCYDGLPAQNFWYTGDNRIAVTGQGQCLDLTDGRKANGNVLQTWQCYDNNLNQVWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF75</accession>
    <name>I4YF75_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957283.1">
        <property type="nucleotide sequence ID" value="XM_006957221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF75"/>
    <dbReference type="FunCoup" id="I4YF75">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF75"/>
    <dbReference type="GeneID" id="18471374"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31825"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF75"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21879" checksum="F7B40A27771906C2" modified="2012-09-05" version="1" fragment="single">MQRLFGFNQAKAPKTSLNDAIKSTETRASSIESKVKKCDQELAQFKQQMNRLRDGPGKRAVQQRAMRVLQQRKVYEGQLEQLQQQTFNMEQAQMTTENLTGTMATVDAMQTANKQMRKQYGKIDIDKIDSIQDDMQDLIESATEIQETLGRSYGVPDEIDEADLEAELDALGDDLNEIDETPSYLQNPDSNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF88</accession>
    <name>I4YF88_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957296.1">
        <property type="nucleotide sequence ID" value="XM_006957234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF88"/>
    <dbReference type="FunCoup" id="I4YF88">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF88"/>
    <dbReference type="GeneID" id="18473591"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59859"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_1_0_1"/>
    <dbReference type="InParanoid" id="I4YF88"/>
    <dbReference type="OMA" id="RALPECW"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="14"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="34747" checksum="A8700A142C1A2521" modified="2012-09-05" version="1">MELKQINTNGTALPACFGHRGASAGYPENTMAAFKGAILDGSEGIESDVHICADDVIVMFHDPELDRLTNGSGSIPEKPYVGDIEHIRTIQTPPQPIPKFEEALELLMKPENRHVKFNIDIKPNNPPERLFSIMHKHISQYPNYENELAPRLILGLWHPKFIQPAKDIIPYAYLAHIGMSLSLARSHFFDHVKILSMSFSSLMGNDGQTFLRECKKSNKGVMVWTVNSRSEMIEASKWEVDGIITDETKYLVQLRKDMSSQFETIVKENGFLFPWSSIKYYKPMTELAAYMEKKYIESYGGEISAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFH1</accession>
    <name>I4YFH1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumble</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_36771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957374.1">
        <property type="nucleotide sequence ID" value="XM_006957312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFH1"/>
    <dbReference type="FunCoup" id="I4YFH1">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFH1"/>
    <dbReference type="GeneID" id="18471977"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36771"/>
    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011154_2_1_1"/>
    <dbReference type="InParanoid" id="I4YFH1"/>
    <dbReference type="OMA" id="GGAHRFY"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="480" mass="53046" checksum="3756A960E7436602" modified="2012-09-05" version="1">MDSYPEIPDISRLSVDTRGAEIVDDITEDKDSRGIYLPFHTESVSHIALDIGGSLAKCVYFSRSSKRRASRKDSSPPPYKQAPPSPKPNGTLTPNILKPVSNETCVPVSPINSSASSYMDVESSSSHPTNKTRPPFGSHGRSRSKHIPGGQLNFVKFETEHIEDCIDFLRNLIEQSANVNDVSLDQMRASIKIVMTGGGAHKLGDVFEEQLKTAVAKEEEMECLITGLQFITSIPKEVFWYSDELVYSVSHKKHKKTTIPQEELPRPSPNPPQFSVSFDKPTEFEYPCLLVNIGSGVSIIKVNSDGSFERVSGTSLGGGTLWGLLSLLTPAESFDEMLALSESGDNNSVDMLVGDIYGSDYGKIGLKATTIASSFGKVFKKGSKKDRKKEFKPEDISKSMLFMISNNIGHIAYMQAEKHNVDRIYFGGCFIRGHAATISTLSYAIRFWSKGTKRAMFLRHEGFLGSLGAWIKNIDEEEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFI8</accession>
    <name>I4YFI8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59912</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957391.1">
        <property type="nucleotide sequence ID" value="XM_006957329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFI8"/>
    <dbReference type="FunCoup" id="I4YFI8">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFI8"/>
    <dbReference type="GeneID" id="18473623"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59912"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFI8"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="262"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="632"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119542" checksum="17619C982FD8F5F5" modified="2012-09-05" version="1">METEQIVRRKSTKGSVADAGIIQYVEVYNFMCHKYLAFDLGPQLNFIIGHNGSGKSAILTAITLALGGRATATNRGSTLKSFIKSGQTSAQIVLKLKNEGTEAYKPSVYGSTIIVERTVKDNGNSLKLKSSSGKTVSTTRQELTAICDHFMIQVDNPMNVLSQDQARQFLSASHAKEKYEFFLKGTQLTQLSDEYQLISENISNARDATVRKKERLPALEEAASRAHTRYKEATKARDQQHKLLEFKNELAWSVPAAIEKDINEEEKGYEVARQRMVAIEEALQAAEMSYQETQAEVDRYESMTLNEDSQLNYLRSEKEKINEILKDHKLRLQNNRKEEADLNQYLNEIQSSIQDFENQKKEEFERLKIDYSAQHAETRKQMEELHEQIQVHNQIDTESDEKINEGREQIGELQNKYAEIKRQKATCEANIQQSQQELMQINASLKDRKAAFGNKMPAILQEIDNQTWIEKPIGPLGRYVKLTDNRWSKVLESVLGGTLNAFACTNLQDRRKLLGILKRNGASSGVIQMGEKSFDFSAGEPSSEFVTIDRVLKFDREEVRCILVNQNRSESSILVRDRQDADQIMRTHPHNVTSCYVLNGLFQVGGGVGSATITLQQYKGAPRLTTDTSEAKKLAEESMAEARKQYQELQKEELTVSKEIEDIRKNADRYKSDKDRAYREKRNCEYQINQLRETLQSDQPVNIAAIDAAIEEQKEEITKVQQQYAAIATKQHELQQYIQPHLEHNNDIKQQLADYDKTRLSIEANLKDAHDHNNQAMTTLNHRRKQKQQESVKVDAYEQHISKIRSDLEIALEQASEICSTRIMTTRSVNEIQRDIQGIEVALRARQERNGSSIEAVTAEYHKALDAVESAQRDINDMNIFIRELKKALDLRTQKWLQFRKHIAMRAKYQFMFHLSSRGYYGTIHFNHGERRLDLMVQTDDQLATQGKRDKDPRSLSGGEKSFSTICLLLSLWEAIGCPIRCLDEFDVFMDAVNRKISMKMMIDTAKSSTGIQYVLITPQDMSSITLGKEVKVHRMKDPERSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU3</accession>
    <name>I4YFU3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_36041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956887.1">
        <property type="nucleotide sequence ID" value="XM_006956825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU3"/>
    <dbReference type="FunCoup" id="I4YFU3">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFU3"/>
    <dbReference type="GeneID" id="18471939"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36041"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056986_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFU3"/>
    <dbReference type="OMA" id="FAGPQHF"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAP NTPase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="300" mass="34189" checksum="67E048C2EFC0C4DA" modified="2012-09-05" version="1">MSAKKVERILSWAIPLIEASKLNRPFFIGLTGLQGSGKSTIVNELTNELQKGGFRTIHFSLDDLYLTHQELKDVSARHPANKLYKHRGLSGTHDMVLAKDIFQQLRESWNDPPGSSIQIPVYDKSLHSGQGDRKSKGEWRTINLDDPIKVVIFEGWSIGFRPLEQSVLAAQHKSAQSSPAGLTNQIAEHTLEDITDINNALKEYDTYFSGPQFFDCLVYLQAMELGYVYDWRDEQEQNLRNANKPHQTKEEIISFVKNYMVAYELYLPPLTSQGFFDTRQGRQLTLTLDKDRNILGSQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW4</accession>
    <name>I4YFW4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_16144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956856.1">
        <property type="nucleotide sequence ID" value="XM_006956794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW4"/>
    <dbReference type="FunCoup" id="I4YFW4">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFW4"/>
    <dbReference type="GeneID" id="18470688"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16144"/>
    <dbReference type="eggNOG" id="KOG3808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152663_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFW4"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="70" mass="7660" checksum="354DC626A2A0D324" modified="2012-09-05" version="1" fragment="single">TALFNFQSLLLVIILLICTCAYIRATFTGLIDKNKTGVLGTFYKCARIGERLSPYVAISAIIMAITLCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ6</accession>
    <name>I4YFZ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956937.1">
        <property type="nucleotide sequence ID" value="XM_006956875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ6"/>
    <dbReference type="FunCoup" id="I4YFZ6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="18475297"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67775"/>
    <dbReference type="HOGENOM" id="CLU_2098721_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFZ6"/>
    <dbReference type="OMA" id="QEHTHKI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="116" mass="13810" checksum="C97C92192E70D957" modified="2012-09-05" version="1">MSSSEEKQTTRMISTLNAINKDKKSDPFHRNHMPPNTRSSFNDRKARDDRLKEMKAREKEMKSETETSRKEHTAKILERRKIKEEKERLAAVKSKADERRRKKQKKREGRSGKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG75</accession>
    <name>I4YG75_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_15957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956852.1">
        <property type="nucleotide sequence ID" value="XM_006956790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG75"/>
    <dbReference type="FunCoup" id="I4YG75">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG75"/>
    <dbReference type="GeneID" id="18470684"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15957"/>
    <dbReference type="eggNOG" id="KOG4086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071681_4_1_1"/>
    <dbReference type="InParanoid" id="I4YG75"/>
    <dbReference type="OMA" id="YWSRPPY"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="15168" checksum="AEB18FEC49E0598C" modified="2012-09-05" version="1">MNTSEVKTEEPQDIPRLENRKKFEIELEFVQSLAHPFYLHALAQQGYFEKPEFINYLKYLNYWREREYVKFITYPHCLHNLDLLMEPSFREAIKHQDVIQALHRQQYSVWLDNKPPSDAETVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG87</accession>
    <name>I4YG87_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_36258</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957020.1">
        <property type="nucleotide sequence ID" value="XM_006956958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG87"/>
    <dbReference type="FunCoup" id="I4YG87">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG87"/>
    <dbReference type="GeneID" id="18471953"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36258"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG87"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="552"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="823"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="937"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="775"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="966"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM22979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1033" mass="117065" checksum="2E09B54E1F6328EB" modified="2012-09-05" version="1">MSGYELDIKLFEKRFKKIASAWKDTENEDYSGFRDADAILVPVGDLDEDSTFKKSTSLQNWLLGYEFPTTITIFLPDNTVIFIASNTKIKILKQLESANDINVELVTKTKDQEANQQALEAVVNRLAGKRIGVFSKDNAQGKSIDDWNKASQGKLGEEVDITSAIATVTAPKDTYEQKNHKYASQLSSHLLKWGMDKIMSYIDSEKKINHYTVAEQIERKAAKNEDETDAKDLSFWKKMKTFNELEYASSEPVYTPIIQSGGEYSLKPSVMSDENNLKAGVITTSLGMRYKSYCSNIGRTFFIDPHKTQEENYAFLLELQKRVIEKMTPGTLLSEVYETALNFVRKTKPELEEKLSKNLGFATGIYFRDSTYMISPKSNRKILKGMVFNLAIGFSDIKDPKKSGKNYVLSLIDTILIADEAAVCLTEGNKSSRDVMLFMENEDEEDSDIAEVKPKKQSSPKKKSHSNDLESAVIGNRMLRGKTRNAGREPDQSTAHKIKEHQKILHEAKNEEGLKRFAEGKDSSNGSKPEVFKRFDSYKREQQVPINRDLRILVDTKAQTVILPINGFIVPVHVSTIKNISKTEEGDYTSLRINFITPGQSVGKKEDVPFEDPDSMFIRSATFRSTDKLRFSDLYKDITELKKLSTKRAAEKREMADVVEQENLTEIKGRRPVRLGEVFARPIEGKRLAGDLDIHTNGVRYTTPTRDQKIDVLFSNVKHFFFQPCEHELIVLIHFHLKAPIMIGKKKTRDVQFYREATDASFDETGNRKRKIRYGDEDEIELEQEERRRRNALNKEFKGFAEKIAEASQDNFDVDIPYRELGFQGVPHRTGVLLQPTTECLVQLTDPPFTIITLAEVELAHLERVSFGLKTFDIVFVFSDFSKPVMHINSIQASQLDNVKEWLDSSDIPISEGPASLNWSAVMKTVNEDPKDFFESGGWSFLGGSGDQEDGSDESEPESQYNMSEDAVDDESEDSDEFDDSNDGSESDASDASDVSGESWDALERRAEKSDRKHYKGLDDEEGASKSSKGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGC2</accession>
    <name>I4YGC2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_43930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957053.1">
        <property type="nucleotide sequence ID" value="XM_006956991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGC2"/>
    <dbReference type="STRING" id="671144.I4YGC2"/>
    <dbReference type="GeneID" id="18472312"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43930"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGC2"/>
    <dbReference type="OMA" id="YRDSCAN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="75" mass="8894" checksum="58642CE9EEAE0272" modified="2012-09-05" version="1">MADTVASKEECMKNRVPLNWRDQCSGLLIPLNVCRHKNLYAPWACTDERHGYEKCQYDDMMRRMKVLSQQKSQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD1</accession>
    <name>I4YGD1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957062.1">
        <property type="nucleotide sequence ID" value="XM_006957000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD1"/>
    <dbReference type="GeneID" id="18473524"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59734"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="InParanoid" id="I4YGD1"/>
    <dbReference type="OMA" id="TEPIVLW"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="530" mass="59613" checksum="B54692B9CFF2C0A2" modified="2012-09-05" version="1">MTKVHPVEERKPHEDSTLTESSQAYFDKTSADGKIELTEDAAPEVLGYSWSTAKKWYILSVIVVIQISMNLNASIYANSVEGMTEEWGISAQAARVGQCVFLVAYGFGCEFWAPWSEELGRWSVLQISLFFVNIWALMCSLAPNFGTMVVGRFLGGLSSAGGSVTLGLVADFYNVDTHQYAIAYVVWSSCSGSVVGAIVGGFIHSFSTWRWVFWIQLIFGGFAQAIHWAIPETRSSVLLDREAKRRRKEAAKEGKELNIWGPGEIRPYKFNLKETAIIWMRPFEMFVREPIVLSCSLLSGFSDMLIFIFLESYGAVLSQWGFKPWASGLGFVPILIGYFIGWFSFFPTFRSQTIRRKQDPFSVSPENRLWWLLWTAPLLPIGMLMFAWTSLEERGIHWIGVMISSAVVAIANYNIYLATVDYMVAAYGPYSSSATGGNALARDVLAGISAMFATPFYSHFPNYTLELPTTILACIALVLIIPVFLLYFYGPQVRNKSKFAQLLAENRETSHLKSQVREEKQSRFEHVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGF5</accession>
    <name>I4YGF5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_11209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956840.1">
        <property type="nucleotide sequence ID" value="XM_006956778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGF5"/>
    <dbReference type="FunCoup" id="I4YGF5">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGF5"/>
    <dbReference type="GeneID" id="18470589"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_11209"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071690_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGF5"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="24131" checksum="8235CAA12797EAB7" modified="2012-09-05" version="1" fragment="single">MPKSRRNKLVSLTETEKKTREHKEALVDLIRQAADENKYCWIIEAGDMRNSSLKDVRAAWKGTGRLFFGRLKVMAIALGTTPETSHKPELYKLSEHLSGSAGLFFTNWDENEVKEWFDSFSKPDFARTGNVATQTIELEEGPIIHRPSGDTLPHTLEPSLRKLGLSTSLLKGVPTLLSAHTVCKEGQTLSAEQAQIIKHLGVMMSNFKLQVKALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGV3</accession>
    <name>I4YGV3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_27329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956589.1">
        <property type="nucleotide sequence ID" value="XM_006956527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGV3"/>
    <dbReference type="FunCoup" id="I4YGV3">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGV3"/>
    <dbReference type="GeneID" id="18470990"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27329"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGV3"/>
    <dbReference type="OMA" id="KKWIMRA"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108296" checksum="EDF43987A5558E89" modified="2012-09-05" version="1">MPFNSSINVPIKLFFNAISKRSTSHPIESILFAFISVTLAYFKLAHAVRHDGFATADQLDIDNEHDWWWSVALRAFGGKTWSLAKNADSVDIMIVLLGYILMHGTFVNLFVEMKKLGSKFWLGMSVIVSSVFSFVCAGLVAYYSDVRVDPINLLEALPFLVITIGFDKPISLARAVFSSHDLAPPVFHPKAGDYFTLGTPLEHPSEESQVNKVKLATPTPASTIVHRANTKVGPRIVRDTALEIAVLILGAASGAAGLKEFCILSALSIGFDCFFLFGFLSPILTVMVEVHRIKLLRGTQNTIYTSEKVNNPLTKLKVLLLSSFLILHSLNLLTTLSSQTSLKRFLDDSSENQSASIFSDAFNKANNLFDNDANSNHTKVASLAVLEDFMSGWTHLVGDPIMSKWIVLILGSSIFLNGYLLKGLGGGSGPYTVQIDNKGSIAARRHLTDQTDDKDGLKLKAYHMQKVKETAEKVNSLPSLPPTLPSVKEIDRPLLVNDAGHIGHPKIIEESLSTPAQETHFGRRSLEECSELLQRSKDSPSITPSTEFSDEEFIMLVQQGKIPMYALEKLLGDFERAVKIRRAVISRQSTTATLEHSKLPMRYYDYQQVMGACCENVIGYMPIPVGVAGPLKIDGDLTPIPMATTEGTLVASTSRGCKALNACGGVTTVLTRDGMTRGPALEFPSVVDAARCKKFIDSKHGTDYITSHFNQTSRFARLQQLKCTLAGRTLYVRFATTTGDAMGMNMISKGVEKALAALHEQFPTMQTLALSGNYCTDKKPAAINWIEGRGKSVVAEAVISGDVVKNVLKSSVSDLVRLNTKKNLVGSAMAGSIGGFNAHAANILTAIYLATGQDPAQNVESSNCITLMESVNNDNDLLVTCSMPSIEVGTVGGGTVLSPQGAMLDLLGVRGANQVEPGANAQRLARIICASVMAGELSLMGALAAGHLIKAHMQHNRTPQPSRPQTPSLLTPVTPSTIGTIPTVNSTTSLNALRVNALKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ0</accession>
    <name>I4YGZ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ntp1_59509</name>
        <name evidence="8" type="ORF">WALSEDRAFT_59509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956624.1">
        <property type="nucleotide sequence ID" value="XM_006956562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ0"/>
    <dbReference type="FunCoup" id="I4YGZ0">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGZ0"/>
    <dbReference type="GeneID" id="18473395"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59509"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_1_2_1"/>
    <dbReference type="InParanoid" id="I4YGZ0"/>
    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="809" mass="93436" checksum="DDA13D684221E319" modified="2012-09-05" version="1">MISSSQQSKQPQKRKSFATEPRPDLFSTPDEYYDIEDKILNRTRTLSISSVEPRRRRNQIEGENVSRNRRLSHDEPSKIPRRFLVNVDDTLAVVLEQEDTDRNAQISITDAGPKLFSLGTASSNGYNAFDIRGNYMLSNLLQELATAKDQGRSQILLDEARLAEDPLQRLHRMIRFTFWKNLTRTIDRKGLEKIILDPKDRSEEKNPLIYVPHDTPHIYDYYVNVAKEKPELNLRVERLPKYPDDPQFVRSISTKPGLLALEMRESATEPGQLEGIPFVVPGARFNEIYNWDSYFMALGLISDDLIDLAQGIVDHFIFQIRHYGKVLNGNRSYYLTRSQPPFLTDLALQIYRNLPEDTEKENKEWLARAIRAAIKEYHNLWMTEPRLDRETGLSRFRPPAIGIPPETEASHFLHVLEPFAEKHNMGVDEFIQKYNDQEVIDTELDEFFMHDIAIRESGHDTTTRFENCCADLATVDLNTLLYKYEVDIGFAIRDYFDDHLELFDEFDITPSPFTEEVSEKRKSTETVQHSKEWFERAKGRRHRLDHYCWNEQTGCYYDYNTAKKEQTTFESVTSLWPLWAGCATEHQAKKLVENAVPKFEVMGGLVSCTEESRGPITPENPVKQWDFPYAWPPHQVLAWVGLERYSYMEIAQRLAYKWIYLMTIAFVDFNGTVTEKFDAVKLTHMVDAEYGNQGIDFACVPREGFGWSNASFQVGLTFLTSSMKTALSVCTTPEVYFSRRQAEDDETLSRETPSIPPALLVSKGGIESLQKQPEKEKQTVDADKEIQGPLADKRKRMSIDISQAIKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH98</accession>
    <name>I4YH98_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_43394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956724.1">
        <property type="nucleotide sequence ID" value="XM_006956662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH98"/>
    <dbReference type="STRING" id="671144.I4YH98"/>
    <dbReference type="GeneID" id="18472286"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43394"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403968_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH98"/>
    <dbReference type="OMA" id="QMVSTGC"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="681" mass="77769" checksum="37E456844003F0B7" modified="2012-09-05" version="1">MKSSKLLYKSSRIEDYKQITNLFKNLFKSTKPSIKQSNELFNRNLNSKNPSIDTLVTHYNNLKTSSNKDFLDNNKLSKTLSILSKQSSPFLDQFCEDIRNHWKLELSRRDFQFIIQAYVNQRRINKAVDIVRTLDNPSLAIFSVLLTGCSTHNDYNAYQRVLSIMEERDIKPDLHIYNARLKLAFQYHDIDVVDSLLEDLKMDGYQPDLFTHTILLDGYSRLHQWSRANESEAFLRSSDTDIASWTCILLATGRQHGLEKAKEVVDEIFLAGLSPNDIALSHLVGLSQRPSSSEDAKILIDDLSAYAGVEPGKHTYRAALEHLLMVNLDEAYEFCISIPDQRSLAVTLPLITALAGNKDGTALDNLRKMLSIYDQLDRERLDTRVLAHMLRTCAKAGDVQTAIDILVDMKTNSVDLESQFTTSFIVTLLHASSDYYQAFRLYANVVDSKATRLDAAGFSTIIAEFCGLKFQDENIVPAVLFSEILNDMRKAGYPPDCKTYTSLLDYYAHVRDNRSIAKIETLLNVDRSIMPDIYLHNALLNAHNRVGNGGKCVELYNALLFSRRADNASLSIALDVSGSRNTPADSIHIWNLSKKYIKPNRKNWETLIEALVRRRRFSDARNVTFNSEEFKPDTNAIEILFRMTRASRDEKEITILRNYLLENHIDDYNAIKNTVDIPWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE7</accession>
    <name>I4YHE7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956769.1">
        <property type="nucleotide sequence ID" value="XM_006956707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE7"/>
    <dbReference type="GeneID" id="18472812"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56468"/>
    <dbReference type="HOGENOM" id="CLU_1564110_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHE7"/>
    <dbReference type="OMA" id="RCVPQAS"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="171" mass="18477" checksum="909618AACAE21A7F" modified="2012-09-05" version="1">MSAADTLKKETTDEDIQYSSGSEEVSEEVSEVEQAATEAVVSPNQTVEVVQPVEPSKKNVTRKQRKKSAPTGVTDVADLTKVLNTAGQVIDTATKTIKDPQEPSEVIQEAQPTKVVQPIIEEGLKSVVQTGKKADGSNKNNPISLRLDLNLELEIFIKAKLHGDVCLKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI6</accession>
    <name>I4YHI6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">La-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_27503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956803.1">
        <property type="nucleotide sequence ID" value="XM_006956741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI6"/>
    <dbReference type="STRING" id="671144.I4YHI6"/>
    <dbReference type="GeneID" id="18470996"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27503"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710189_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHI6"/>
    <dbReference type="OMA" id="WITEFIG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="375" mass="42058" checksum="BBCEA98DE0926B40" modified="2012-09-05" version="1">MTTNVWQSRQAVAAPQELPVKDEKSWPSASDAKDRDREAEKTNKEKSQSSTPTDSNSTRRGKKNWVTVPVEEVLPVQSRRSQNKKSNKAKRSDANKSSQRANNKSTKSKNPQQQQRKSSNRKPSKTSDKNQKNFAPVVPAMPSSFQMFGAPNTQAGHTYAPMPMPTPITTTNYPLDPLRFYLLGQLEYYFTTQNLVRDFFLRQQMDSDGWVDIPVFTTFNRVKALSVDLYLLRDVFSMSHLVEVYFFAENAEPSQKEEGVLQKESLDMSQVQKEIDIIASNTNPVGKVRLAHGVWKKWVLPDAPKSTIDIDSLPPAEDPQFDENATPVEASKYNEEIAAKSGHSGQSNQSTQPSQQSASSHTIDNGSNDANKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL4</accession>
    <name>I4YHL4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_62819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956828.1">
        <property type="nucleotide sequence ID" value="XM_006956766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL4"/>
    <dbReference type="STRING" id="671144.I4YHL4"/>
    <dbReference type="GeneID" id="18474791"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62819"/>
    <dbReference type="eggNOG" id="ENOG502SAB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702492_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHL4"/>
    <dbReference type="OMA" id="RPKANNI"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="45586" checksum="123A9101C1AC3CCA" modified="2012-09-05" version="1">MQEGEITKRLHIAGLTPSITLKDLENRFSRFGSVLSVEECGRDGNGDPRKYCFMNFKSSQAQLNKLMQTFSNSRWKDAKLRISEAKPNYTARLEIDKEKAIEKERKREFKQARKLLQKRLRGALKTYAKDMRLTTPYNAKWRSGWYITPAKHLIHPIHIRPDHPLPIPSTSKSAPKVTKEAKAPKRSKHIIIDPRRYGSIHYGENMLGNENVPIDSRPWLCEEDDQGRVIWYKEGAENEIYDFSFRDPLKVYADNVDFYNHLDDKVVPSKPKQKTDTIDEIEYQVRKLEENEKRYDDDALSDDDEDEIFAMLESQRLREERSESPLFEGAQAKSFDWLSSAPEPDNKQVQVQPSHDPAAEKIKEEHRSQNALLDSLFQNDGFGRKASIGLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ5</accession>
    <name>I4YHQ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956175.1">
        <property type="nucleotide sequence ID" value="XM_006956113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ5"/>
    <dbReference type="FunCoup" id="I4YHQ5">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHQ5"/>
    <dbReference type="GeneID" id="18471233"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31030"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007879_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHQ5"/>
    <dbReference type="OMA" id="QPIYPRQ"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="132"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="793"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="100376" checksum="FF2DA8FD2CF11C1F" modified="2012-09-05" version="1">MFLDSVHSTNCVNLLWECFKLGNSLCHLFNQLGLEQQLEVSDNYDINKQSICKKGVARFIISCKLLGDTTTGWTSDDLFTVTDLYKQDTSGFIRVLHTVNLVLNELDKRGKLIEVTPTQTDDAPILQSTNQSRVKITQELIESERKFIMDMELLQSFSNEIRQSNIFSHDTHHSIFTNLHALVDFQRRVQISLEEAFEVDQSGGIGLWGKAFTDHEQDWLVYAPFVINYNHANQIVLEQADAIQNGTPSGLSHYEVQALLIKPTQRVCKYHMFLDEIRRKTDEESPSYSDLSNGYDAMKRVTGEINELQRQKENVEKCQILVNRVEDWKGHHIGSFGNLVIEDMFNVNKNQVDREYHVFLFEKILLCCKEVPENRNQNGSDKGGKERKPSKSNSLLKRKDSSFHQFDPLRRNIPLQLKGRIYLNNVTHVIPYFRDIQPGSHNLEVWWRGDDDLESFTLKCRTSEQLELWKAALDKQLGQVAIRKQAMEDAIARGEMPSSARKQSVSSAGSHSYSASSRRPSGQQSSQWPQTPILDTNLISPMSNVSMEDKIPSPIYPASARQQRAKTEDSNAHSFQQWKLQQQQQFPPRSVSQQGLNLSAGAERALRSQSSKSALRQTPVGAPPVPSVSAAMAKAGSLASPSTQPQLSPHNRNRSLSSPNTYTQQNPFDEQNVSSNSSFVGLSNAHQQMVAKQQHMAQQQAPHEDELHDGSKVSLGAGSYSEAPTQRSWVSKRFSESSTLTNSSQDSSAGDKRKVAPISTSTNSTSSSLASSPNNDNPPTPTTYSNGGLLSDKMKVKVRYNEDLFVLNLPPSIDHSSLVTQIARKVRLCTGFRSHLPYSDNLVTSANDTDDGLITFKLKWIDEEGDQILVLGDEDVGMAMDWAKNQGGGAVELIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS1</accession>
    <name>I4YHS1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_27024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956190.1">
        <property type="nucleotide sequence ID" value="XM_006956128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS1"/>
    <dbReference type="STRING" id="671144.I4YHS1"/>
    <dbReference type="GeneID" id="18470972"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27024"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004823_3_0_1"/>
    <dbReference type="InParanoid" id="I4YHS1"/>
    <dbReference type="OMA" id="GHTISMW"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="621"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="1">
        <location>
            <begin position="735"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1202" mass="136232" checksum="8020591784AA3A42" modified="2012-09-05" version="1">MGDFQKIHRYFSPLLSILTDKGVNELLGDTNSINNLSELLSPFDVLHNVPLRTSQLETHHAPSFHLRFNELAELDSSTEELHKVVEKSAGDATVSTNSDNIYENFLSGILKHHALVPYCTFQHPVAFILATTTKHADPVSELARLAQEVSFPDAYAKRAYMSATPNYVLRYYVLVHDANDGDMDHARNLLEKAKRAHGIHCALLIINSKQSKEEKEVDETVTKTYGHSRAHSLDASDLTVIRAFVREMVVQSLIPWMEKCARDWNQLFVTNRKGFTNKLFSSFGVSRKWAAQQAPSRAINSSAPVASFVSSEKIYPSTTHEATFRRLADFAFMIRDYKLSAQVYNQLRRDTAEEPEAYLYMASANKMLGLSHLLSPHSPTSTLDTTVQYLDEASLTWFTTKNATDRAQMIRATLLYIESFRARGSSGLVIPSSFIKAASTGNGLSSAIMLEQAANAYKNHMKPYKRKACLYFAQAATVYESHGKHALARRCYENCDTDRFPFLNQALGRLANEEDAPILITKSLRYGGDQRLLDDWRDCLRKDENPKVTFPLEVFDKGMTYIRDPHAHVYTNKKSERIFDTLEKELKTSSEKIDDRIDIDIDEVFHAVLVARNPFNAGILINNFQLEFEGEANIECLNKDLELGALEINEVVFKCSVSSASTVKLNKVDFMIDNICKVTESLQRNGARLNNTKEHRMGRFYAPDLSLEVRVNEPTPRLLTNLECFPQRMGLGEGYLAHINIQNIGKVDVDDVRVVVNEQSFVALGVDENISNAQDVYKQSLETSTEQSRIENTLRSSAPYDIGKDLKPGYTHSIPVLLRGDNVGKKALHLIVVYKQKSHENHHKVNRLLHVVDIRPVVEVKLAAQPSKMQIGSYDLSLEIENVVPDSQIEITQVSFVSPAWKCIGEMKDMNLAFEDIAKQEFKVEFTEDFNVEDSLQTQTYMIDKMAEYLQGDNITENYPPPVNVISSHLTHSKKYIPTSQTGLFHMMMSARRYLRQMTFGYEFKSIPWNVQSHLFPLFEANEGDVVVCWKMGDRVGHALVSGLVLGAREGLTRRIGEKVKQSKNIKSVMYASKVRDRERALSELTKSRYSVYDMPIIVNTYTPSPINHDFEQNPELRISVDISLFNNSIYRNVESKLQLRDEIEGMMVPVREFTADVSAHDTVNVNIALNMSKAGRYKLKQLLLTIDGLNYVVNLNEIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT8</accession>
    <name>I4YHT8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_42695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956207.1">
        <property type="nucleotide sequence ID" value="XM_006956145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT8"/>
    <dbReference type="FunCoup" id="I4YHT8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHT8"/>
    <dbReference type="GeneID" id="18472260"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42695"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="InParanoid" id="I4YHT8"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697812" description="Selenoprotein O" evidence="10">
        <location>
            <begin position="25"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="498" mass="56419" checksum="D812995E272F1E04" modified="2012-09-05" version="1">MIYYQAIKLLLMINFILMRLDTLGHQFGFFAGELGDGRAITVLDTVDANGPVQLQLKGAGRTPFSRFGDGYAVLRSSVREFLASEYMSVLGIPTTRALSLISLPDLEVERETVETGAIVARLASSWLRIGSFQICNPPQGSYFGLERDWSTMSHLTHHVRNELFDGISFKDVILEVAKLNARTVAQWQAVGFCHGVLNSDNISLLGLTLDYGPYAFMDVYNSGHICNHTDQTGFYSFKMQPSRVLWDCQQLLNSTAEVVGAEEEGVEITPKFAFDENGKEHFDNLFRWRSKGLEISDEIDDIFKDTFQEEYLEQMGLKLGLKKLTKADHLDIVNVFLTIMQDQENDYSSTYRALSSSNNPEEIADRILAYKPVTSFLQDGAKDAWLGWLTTYFDRVNQDIEAGLWGDKENAHEERLKSMRAHNPRFVLRQWVLEESIAKLQAGDQSTFDKAFEMSLKPFDNYHENVADDQLNEQQLEEKRLCGLGDESLLGYQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI30</accession>
    <name>I4YI30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956292.1">
        <property type="nucleotide sequence ID" value="XM_006956230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI30"/>
    <dbReference type="GeneID" id="18473274"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59294"/>
    <dbReference type="HOGENOM" id="CLU_998207_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI30"/>
    <dbReference type="OMA" id="HYSARCY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28154" checksum="CEFA833E034B901C" modified="2012-09-05" version="1">MNPTIEVPASGEVSAVAAVPGLIPPTPALSTASSPQPSIREGGPSTPAPEPAAAVIIQDSPLTAALTNLIELAKQENWQALSLSALEAETMFAQVDPDDKLWEAIYNLSILSDLLLDNLPAAQATLNRSTAIVKDRLGVSISYYFNQQYKDALQALTQLATQPQTLVNDAITSVFNHILSLYQTKVLMRALNVVALSCSAVQVVKVSESIGVPHNKLVDILKNLGWSFSEDGSVVYPLTSSSTQNLEKPTLQNIASSVYLLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI53</accession>
    <name>I4YI53_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_59307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956313.1">
        <property type="nucleotide sequence ID" value="XM_006956251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI53"/>
    <dbReference type="FunCoup" id="I4YI53">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI53"/>
    <dbReference type="GeneID" id="18473284"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59307"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="InParanoid" id="I4YI53"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="217"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="522" mass="59504" checksum="21555B5F3869F5AB" modified="2012-09-05" version="1">MTKSAIKKLKQQQEKEAKKKATQERLAKEQTDRQAAGGEDTAAQNYGPIKVHSQERTNIERTQIKDIDASYKDKHVVIRARVQTSRAQGAKMVFFGFRQQDSTIQGVLVVKEPAVSKQMVKWAGSLGDESIVLIDGIVQLPKEPVHSATQQDAEISIQKIYTIADVPGGKLPFTIEDASRPEAEYEKEDAQFNKVHLETRLDNRVVDLRTQTNQAIFKIQSAICKLFRQSLDNRGFIEIHSPKLMGAASESGSSVFSVSYFKSQAFLAQSPQLPKQMCIAADFEKVYEIGPVFRAENSNTHRHMTEFTGLDLEMAFEEHYHEVVEVMDEMFKNIFRGLKQQYAKEIEIIKAQFPHDEFVFPEETVKLHYKEAIALLREAGREVDDFEDFNTETEKFLGGLVKEKYNTDYYILDKFPLNCRPFYSMPDPADNRYSNSYDFFMRGEEILSGAQRIHDPEFLITRMKEHGINPADMQGYLDAFNVGAPPHAGGGIGLERVLMLFLKLNNIRRASLFPRDPKRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI69</accession>
    <name>I4YI69_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_67290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956328.1">
        <property type="nucleotide sequence ID" value="XM_006956266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI69"/>
    <dbReference type="STRING" id="671144.I4YI69"/>
    <dbReference type="GeneID" id="18475233"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67290"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1836677_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI69"/>
    <dbReference type="OMA" id="CAPTHAK"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16175" checksum="8F6B2A0178E0D113" modified="2012-09-05" version="1">MTESQQHKCDDCQKLFSRYEHLVRHINSAHRNERPHVCSFCSRSFARSDVLTRHITLHTRPATAMTKDRRHRIHRACTNCKSSKLKCDGLKPTCTRCNQRGKQCSFMAEMPKPEPFTPASPPPTKKLRLPSISSWAPDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL6</accession>
    <name>I4YIL6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_43052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
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    <dbReference type="OMA" id="RTIKFGP"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
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        <property type="entry name" value="FHIT"/>
    </dbReference>
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        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
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        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
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        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="83"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EIM23808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="18453" checksum="88874D9A900A7AB1" modified="2012-09-05" version="1" fragment="single">MNKQLFHKFDVTSQTFYRSKLSAAFVNLKPIVPGHVLVIPQRNVDRFTSLSPEEVSDLFQAAQRVGKVVEHVWKSTALTLSIQDGVDSGQTVPHTHIHVLPRRPGDFPTNDQIYDELQKHNIQGDLEQLVREKKLKMDSDRQPRTLEEMNKEAEMLSQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
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                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="53" mass="5998" checksum="065DAA7B4EFEF6C0" modified="2012-09-05" version="1" fragment="single">GERRIATFRCDCRGVILHKDVRGRHVGAYYDLCWDTARSTSGCVFTYSKVAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ22</accession>
    <name>I4YJ22_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WALSEDRAFT_26701</name>
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        <lineage>
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            <taxon>Wallemiomycetes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
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                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="wse:WALSEDRAFT_26701"/>
    <dbReference type="eggNOG" id="ENOG502SABM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607214_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ22"/>
    <dbReference type="OMA" id="IKMEDHT"/>
    <dbReference type="OrthoDB" id="2505754at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="383" mass="43239" checksum="25DCFE8F78454818" modified="2012-09-05" version="1">MTEFNEEIENKKIDNEIDNEIDNVGKANTESLSTPQLDEQQELSNSPISTRKSLDNFDDAEEDFIKMNDKTVDSKVEDVTPVESVEEFDKRMSQIGLRTPPDSSIASDIDDLDNSARDRQKILEELANLRSENVALMTENEKLSESRSITQQELDDEKKARVDAEEIIVQLRTRVEESRNGVMKLQQQQQEQDKSRKRQETEQKRSSFILNEPANLSKRASIKSHKRLSSMSADNAKTNLKDFHLQPQQAPSSNRSSQIIDMTNLQMENANLSNELQRMKKEIDTLREAKLSSDNALRALREFMDSSGEDKPKGLKLPPLPTDEDVPTPTTAHKSSGSWFFGRQSSGHQPSSSNASSTHDQNTDGGFDKPSTLRSISSFFGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ36</accession>
    <name>I4YJ36_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_30770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
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        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955813.1">
        <property type="nucleotide sequence ID" value="XM_006955751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ36"/>
    <dbReference type="STRING" id="671144.I4YJ36"/>
    <dbReference type="GeneID" id="18471175"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30770"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJ36"/>
    <dbReference type="OMA" id="EDTCCFI"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013356903" description="ribonuclease T2" evidence="6">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="287" mass="33186" checksum="82D96E99419A623C" modified="2012-09-05" version="1">MKLEIYALLFGIASARVLRVPENKDINQCPKDLPVSCSSSHVDNGCCTETNGIILLTQFWDWHYSPYEGREDTWTLHGLWSDHCDGSYSQFCDKSMMLHNISTSILAAGETELYNEMNEFWLDNRGHNDYFWQHEYNKHGTCYSTLKPSCRTDNGTSVNVLVDYFKKIVETYKGLPTYRFLEKKGIVPSSTRKYKFADIKRALKEEFGHEPTIHCDGGGDKIHEVWYSYNLVGPLLSGKLIPREPAARDNCKSDVYYLPKHQARRHQVGEFQEESFTISETEIELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ51</accession>
    <name>I4YJ51_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zf-UBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_30779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955827.1">
        <property type="nucleotide sequence ID" value="XM_006955765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ51"/>
    <dbReference type="FunCoup" id="I4YJ51">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ51"/>
    <dbReference type="GeneID" id="18471178"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30779"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009969_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJ51"/>
    <dbReference type="OMA" id="RFNSIEP"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="223"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="525" mass="58388" checksum="0CA82F1E183158D4" modified="2012-09-05" version="1">MERASSSTQSTTTPSPPIAKYYPSAREGEVDMTGVVHLFKDSRSLEESDSDVMNELNYIQTSTSAGGGSTERNAIVGILAVPSSMSPSDLLEFIRPALDAISHIRILRDAAPNRYITLIKFKDYRDALEFKEMYDGIPFSSLNEEICRVVRISSVKIQDTKESASFDNFGDGWISKHPQQQQCTELPTCPVCLDRMDGSTTGLMTIPCNHSFHCSCLSAWPNSRCPVCRYSLPKFQPAKRDEMRTQCASCGKVEDLWICLICGHVGCGRYGPGHAYRHYEQTTHLFSLDLETQRVWDYAGDGYVHRLIQKSDGKVVELPSATSHSLGSSKGKESADGNTDKGGANDEIVAMEFSSLLASQLDTQRSYYEEQQLELHARLESLESVVEAQKHSRESDDDLRKENARLEKKVIKSNEVLHHVRRQAEEEKSFSEGLLTRIDKLIEQNESQSQIISTLTAENGDLKENVRDLMFFVEARDKVPALAGGELSGGTVGIAAPAPAPSTSSQKKKKKKEKEKEKRGDNTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ86</accession>
    <name>I4YJ86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_34564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955861.1">
        <property type="nucleotide sequence ID" value="XM_006955799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ86"/>
    <dbReference type="FunCoup" id="I4YJ86">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ86"/>
    <dbReference type="GeneID" id="18471873"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34564"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJ86"/>
    <dbReference type="OMA" id="DSIHHQR"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="47"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="476" mass="52106" checksum="574510619D5AF4B5" modified="2012-09-05" version="1">MSSSQHLRRTSRANIQIINRDIEDNDSSTSEPLLPSDKQSKESEGSASIGSCVANLANTIIGTGMLAMPDVLSSTGIIPGMILILFCAFMSSFGLYLLSLCSDKLPPRSASFNAIAKITYPTAAMYFDLAIALKCFGVSISYLLILGQLVPPLVTSFFHHLTPSQVDPPSWLLSRHFWITVFVILLSPLASMRQLNSLRHTSYVSIFSAGYLLLIVVLCAVHSPIPLPPAGNVSLGRFDASAISKFPVLVFAFTCAQNFFPVKNELRSNTRSRTTTVIGSSIGVASGLYEIIGVLGYVTFGDNVNSNVMSMYPDTSIFISFGRLAIVILVLSSYPLQVHPCRNSLDKVIRTKSEKEKALASQDEDSEDDEIIKHPPSKTKHTILTISILLLTWAVSMVVTQLDKVLAFVGSTGSTIISFILPGLFYRALTLNDDEPSRKWLRVGSRLLIFYGASVMIFCLAFNFYELFTNSTSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC3</accession>
    <name>I4YJC3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_26778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955893.1">
        <property type="nucleotide sequence ID" value="XM_006955831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC3"/>
    <dbReference type="FunCoup" id="I4YJC3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJC3"/>
    <dbReference type="GeneID" id="18470953"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26778"/>
    <dbReference type="eggNOG" id="ENOG502QPV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026648_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJC3"/>
    <dbReference type="OMA" id="PYQMKLT"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="541" mass="60854" checksum="D4B66B3D72BFC85E" modified="2012-09-05" version="1">MPVAQFAKAELPILESLVNIRNRLTALKKDRKEYIKASDVQSIYSQVIKLITKLNDAREEEEPILGPPNRVDTTLDDVMQLLSLFFLTIGKNKESPATYCQLATIRQLLSHLDESGVYTQNDLKPFQDRLTHLSAIIKRDRENGKHPDQMTKFLLRRLEDCERIYRNLVSSLSVLSVELVPIHQRLVAIRRQLAAIVSKDKPQKQEIKPLLEELRKIDGKRQDGKFLGPGGSSVPPGQAILVGLLEECFEIVQDVNARRDDVAIPLKPIFDRLTEIRMQLERLVLTHRWTLRETDLWNYQLSLQEIDKMRVDGKWVDSEGNQPGGQFALLYLLRRCHGLLYRLISSSEPISEELMPISNKLLTVKKCLNEVLKHGNDFTPRDLYPYHLALYQIDNLRKDGKFYSDDGSIPEGQAIVISHLEECHALIEQMQEGINSSDEDDDVDEDDDDDDNSEEILEDGLQPAQPLPTHSSVPPSVTLAPPTSTLASLAIRSNDSASSQGTTSSSAPAINIPLRSTAAMEPTESTSTSLDTANASQPDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM2</accession>
    <name>I4YJM2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_26864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955985.1">
        <property type="nucleotide sequence ID" value="XM_006955923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM2"/>
    <dbReference type="STRING" id="671144.I4YJM2"/>
    <dbReference type="GeneID" id="18470960"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26864"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="InParanoid" id="I4YJM2"/>
    <dbReference type="OMA" id="YEWDTPA"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="27"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="383" mass="42245" checksum="5B75D8B230E60A22" modified="2012-09-05" version="1">MTSAFKQADHPLLAIPGPVEISDEVLLANAHPSVSHVSPSFVQVFGESLKLLKELVYSKSAQPFIISGSGTLGWDQAASNLIEIGDNALVINTGYFGDELGNCLSVYGANVDHLNSEIGKSVPLDKIRETLKEKKYKMVTITHVDTSTGVLSDAKGIARVIRKSQPNALVVLDGVCSVASELIKFDEWGIDVLISASQKGIGAPPGLSLVWASERAISIHENRKTPASGYYVNWKRWIPVMKAYEENKPAYFATPPVQLVFALNTTLKSMLRNKDCSLEKRFEEHKKISKYFKKEIQSWGLKQLVNEERYEANGMTTIMYPEGVKGSELLPKIAKSGIVVGGGLHKQVKDEYFRVGHMGETVVNDQIRGDINKLLRTIQECLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJN5</accession>
    <name>I4YJN5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955998.1">
        <property type="nucleotide sequence ID" value="XM_006955936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJN5"/>
    <dbReference type="FunCoup" id="I4YJN5">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJN5"/>
    <dbReference type="GeneID" id="18475200"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67024"/>
    <dbReference type="eggNOG" id="KOG2821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1134305_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJN5"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28217" checksum="AAB01FE3C090D18F" modified="2012-09-05" version="1">MIKSLKYYTIKCILNYINSLDNIGDVPYSLIKDILFKCHHNQLLKIEENSPELIKYDDEIWFQLFKSTFIKQFQDLTQPPSSWRDLFLQEQTNQLNKLNKASNNLKLNQKQLELDKLNKQTIITNNLLPPKSKRSSSSLYQKSKQEARMSISGRNARFLKPFKRNLTPQQPAKPVISSFSKAKQTKAPVISTSVKVANSVAARNTQSSSISTPTKSQHNQHPQQIQQNNQSAQSKSIFLPKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW0</accession>
    <name>I4YJW0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_34899</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956068.1">
        <property type="nucleotide sequence ID" value="XM_006956006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW0"/>
    <dbReference type="FunCoup" id="I4YJW0">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJW0"/>
    <dbReference type="GeneID" id="18471890"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34899"/>
    <dbReference type="eggNOG" id="KOG1145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_2_1"/>
    <dbReference type="InParanoid" id="I4YJW0"/>
    <dbReference type="OMA" id="TIVCYQI"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="236"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="767" mass="83483" checksum="4266F19890EB58E0" modified="2012-09-05" version="1">MLRRQLEFLAHGGPYRRISTSQTLLNKWARPAELDLPQSGKEEKKKTTGNTQKTFKKPMNRNNTRKFEGNVTRNAPLATPATPATPPIDDVSVNKRNKLPMKKKKSNRSSLLDSLDDDQPQNQRKEKKNVNQSQNNSKAKVKPKQKQNNTPAKRQVFIPAFLSVANLSRLFNLRLDKLQRTMIHAGLDNVQFDRVLTAEDASLLAMECGLEPVVNEERAFDLYPSPPHPDPDSLPLRPPIVTIMGHVDHGKTTLLDTLRSSSVAPSEAGGITQHIGAFSVPLSGISAVSNDASTLNSITFLDTPGHAAFTNMRARGASVTDIVVLVVAADDGVMPQTKEVIKLVERSGVGMIVAINKCDKPGVDPQQIKYDLLANNVTLEEFGGEIPSVMVSALTGKGLDDLMDTLAVLSEVKDLRAENTGKAHGVVLESRVDKGKGNLATVLVTRGELKASSSIVGGTTWAKVRQMENDKKQAIKNASAGQPVIVAGWKDLPKAGDEVLEASGEEEAKRAINNRIEALERLKTMSELEVINEKRLAHRELREASQDDNVEEIANEEPSIKELNLVVKGDVSGTVEAFVAALEAVGNKEARVKVITSGVGDINDSDITRAVAGEASIVGFNVKATRSIQNASSMSNVDLMVDGVIYKLLDNVKSRVAELLPPITEMKVLGEATILELFDINVKGRQFKRVAGVRVANGNITRQADVRVIRNGDVVYTGSLETFKHHKKDIHHAGKGLECGLGFADFQEVQQGDIIQSIETTSRPQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW1</accession>
    <name>I4YJW1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_42490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956069.1">
        <property type="nucleotide sequence ID" value="XM_006956007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW1"/>
    <dbReference type="FunCoup" id="I4YJW1">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJW1"/>
    <dbReference type="GeneID" id="18472254"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42490"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091076_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJW1"/>
    <dbReference type="OMA" id="KPHNETT"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16662" checksum="9B039A37F0513C3A" modified="2012-09-05" version="1">MVLEIAAQDRKHRLAALKNRTEGSGESILKFRNYDPTSREPKKSSDEIDNLDTVEYAVKGLAESILAKDEELRNEELDVFNIAPKRPNWDLKRELSKKMHLLNKADQLAINTLLRQRLSKPDSNGQELASATNKPTGLINYADDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW8</accession>
    <name>I4YJW8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956076.1">
        <property type="nucleotide sequence ID" value="XM_006956014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW8"/>
    <dbReference type="GeneID" id="18473209"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59176"/>
    <dbReference type="HOGENOM" id="CLU_2348282_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJW8"/>
    <dbReference type="OMA" id="FCVPLND"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="97" mass="10801" checksum="0BF738E7B11CBBE0" modified="2012-09-05" version="1">MKLQQRMSVKTETGNLFGDADPFAKASLTRRSRSSSTASSISQTNSFEYDHHLETPSSACSEESFCLPLNDNIPKRTCPAKTLSRPPSLLFHLPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y544</accession>
    <name>I4Y544_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_34289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960870.1">
        <property type="nucleotide sequence ID" value="XM_006960808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y544"/>
    <dbReference type="FunCoup" id="I4Y544">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y544"/>
    <dbReference type="GeneID" id="18471852"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34289"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y544"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="17104" checksum="BF871F60F7B1F93C" modified="2012-09-05" version="1">MVNVRDVSAPSFIEAYSQHLKRSGKIEIPNWVDIVKTGSHKELAPYNPDWYYVRAAAVARHVYLRKSVGVGALVKFHGGAVNRGHQPYHHRAASRGVDRRVVQSLEKIGVLEKAVDGGRKISQDGMRDLDRIAASIVAAGNEEESEDEDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5B8</accession>
    <name>I4Y5B8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_61603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960782.1">
        <property type="nucleotide sequence ID" value="XM_006960720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5B8"/>
    <dbReference type="FunCoup" id="I4Y5B8">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5B8"/>
    <dbReference type="GeneID" id="18474634"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61603"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_47_1"/>
    <dbReference type="InParanoid" id="I4Y5B8"/>
    <dbReference type="OMA" id="FVHDNSF"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="152"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="578" mass="64659" checksum="627B6CFA68261ECA" modified="2012-09-05" version="1">MPNPNEPGYWGVLMPVGRRDLNSVTFLNEKPLYRFGRHPQENDIILTGKKISNNHCKIYQTGDYDNTDDAGSASTEIVIFLEDTSSNGTYINQVRCGRGVKRRLMPGDEVSFGNPLSNAPGSGDDYRYIFRPRPKKAQSIDENAGGGVFAKYEIGAQIGKGSFATVKKAYERSSGIPRAIKQIAKHKFAMNQKTLKMFEREIGIIKILDHENIARFCDIFEDDQVIYLVIEFAAGGDLLDYIINRGGLSEHETKEIARQMCAAMAYTHEKGITHRDLKPENILLCTKDTESPQIKVTDFGLAKAVDSQTHLKTMCGTPSYLAPEVVLKRAEGYDQAVDSWSTGVIIYAMLTNSSPFDEQEDEPLHERVLKRKVDYNILEKLGLSSNAIDFISKLLVADPKTRMSLKDALNHPWLSGEPLKASRTAPPPPIPVPKFNNRNHVNVVDSTEKDENIKNQIQALQGELKNSSNADSTPYRNGFFQDDDSSSPPKFSIPSSNYSNQNMFSSSPLPSNNKNGQNYNPKSDISCSADMSQLQLQHLSPMLKRKLPAEASDENHDEYGKKKASDNYALRERKQVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5D9</accession>
    <name>I4Y5D9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960753.1">
        <property type="nucleotide sequence ID" value="XM_006960691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5D9"/>
    <dbReference type="FunCoup" id="I4Y5D9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5D9"/>
    <dbReference type="GeneID" id="18474624"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61587"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434268_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5D9"/>
    <dbReference type="OMA" id="SVENELW"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="630" mass="71430" checksum="2DD557B35612662C" modified="2012-09-05" version="1">MSVEKKRKMSKVRVCDNCRRRKIKCDIEDMLLFGVDSCSRCRDTNSSCTFEEIAGKGTKYKDLYQSLHIKYDKFVDLFQKFHPGVDMETFSCDFSEESSSSYRSFIQETPIDLKTPSRALEIETAAVEAHINNGLYPHDKRILGDASAFKLKPVEQIRQLAFGSPGNFFLHRRAEFWSDLLWRDKDDGSFNPPESLISTLVDHYFSRTNLFRPLLHKQTFFAQWSIKAHDVDFQRLLWLVCAIGSRFYDDSRVLDKSDIDRDGNVTSWHSAGWPFFLKFLAIAKPMSGISPTLADLQQSVLAAVFLHSTPYHASSWTLAGQALVLSADIGAHSGLVYSDELKNELRIRAFYNLFQIDVETSTFQGRDCISQQLVKIMRPSPLQDELGTPSESGLIFFNAFLSLLVITRDVLAKIYNEGTIRDAQNDQQKAARILDTFNQLNSRLDKWFMGLPSYLQWSGRKDDIYVFIQRSCLMGSYLMVQILLHRPFINACGELLSLSSISSAVCINCALSMAHVASEFKDVDPRTDTMVTNVFVICVAALTSKWVAKLKGGIIGAVVQVDNAIDELHNYLKLREKHYYVAGRLADIISYLKDTSESNNLDNLFTISNEELFNLDIDSLISSTVASLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H0</accession>
    <name>I4Y5H0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960709.1">
        <property type="nucleotide sequence ID" value="XM_006960647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H0"/>
    <dbReference type="GeneID" id="18474607"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61563"/>
    <dbReference type="HOGENOM" id="CLU_1490129_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5H0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="20909" checksum="E0A98554992885E7" modified="2012-09-05" version="1">MSKFTVTHHSGYDKVYSGKFRSRHEYKYLHHESKFITRSSVTESLIGVTDDYYSVTLNGQTFIWVPSAPHYLSNSEVGVQIWSELNDMGKFALVDNTTLTEVASYEKHHYLDNEGFIILKDNQKAHRHTFIAVLLALRPFVDFEDTSSISKREARREARRRSRKFTSEYHGGYDNGGSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H3</accession>
    <name>I4Y5H3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_49301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960712.1">
        <property type="nucleotide sequence ID" value="XM_006960650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H3"/>
    <dbReference type="FunCoup" id="I4Y5H3">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5H3"/>
    <dbReference type="GeneID" id="18472494"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49301"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5H3"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697647" evidence="4">
        <location>
            <begin position="21"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="675" mass="75403" checksum="958AE80EC2D4CABA" modified="2012-09-05" version="1">MYHQLAVLGLVLLLTYLSQSSPYHLAVKLWRIIIYVFFREVKARGTYNIPKDNTPVIFVAGPHHNQFLDGLLLSSEVLRASNRKLSFLVAEKSMKRIFVGDMAKAMEAIPVKRAADDAKPGNGTIYMKSDQPSTHIYGIDTKFTTQLESKMSISLSSSLGGAHAEVATVISDTELVLQKEFNKEQSRKVLLSAGDANVDHAINYKVLPYIDQQNMYDSVYKRLEDGGCIGIFPEGGSHDKTDLLPLKAGVTIMALGAMSNNPNLKVKIVPVGLSYFHAHKFRSRAVIEFGTPREVSRDLVNLFNEGGLSKRKACGELLDTIYNGLKSVTVQAPDYETLMVIQAGRRLYSAPGQHPTLGQVVELNRRFISGYLEYKDEPKIKQLRNKVLKYNRRLQDLGIRDHQVDSATKSFWKAAGLLFYRMELLFVWGTLALPGALLHLPVFFTAKCISKKKAKEALAASTVKIKARDVVGTWKVLVSLTLLPMIYLFYIISATIITRKYGKLLGLSDEVINWTPLWTLCVLPFLGISALKFGEVGMDVYKSLPPLFLTLLPGKENELEKLKSKRIALSNELTDIIEEYGPKQIEHFEKKRVLSSHESQQKEPSTTGNNQTTMQWLDEMLFGWSATKKADENSNPSSRDDESSTGEENYETVGEAGDFDAVASFLEANANSNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5U1</accession>
    <name>I4Y5U1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_49173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960609.1">
        <property type="nucleotide sequence ID" value="XM_006960547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5U1"/>
    <dbReference type="FunCoup" id="I4Y5U1">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5U1"/>
    <dbReference type="GeneID" id="18472485"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49173"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5U1"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12427" checksum="791A28A1FDD1E9C4" modified="2012-09-05" version="1">MSHGKHSKFRACLMCSYLQEGKEFKLKGCPNCPFLEMKGSSESVTDCTSGQYDGIVALTQPKGSWVGKWQRVNTCEKGLYAVRVTGRLADNIVDNLQAHGIPYRPRDEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6B7</accession>
    <name>I4Y6B7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_66263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960434.1">
        <property type="nucleotide sequence ID" value="XM_006960372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6B7"/>
    <dbReference type="FunCoup" id="I4Y6B7">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6B7"/>
    <dbReference type="GeneID" id="18475102"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66263"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029048_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6B7"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="45092" checksum="592C89C0099701DE" modified="2012-09-05" version="1">MFYGMEWRIIKAAVWYKLIAIIIIYICTTIIPSFDSSADIILSDESNSFIRALTKPLLRWDTFHFANRATRESSTWKWDYEVAFMPLLPLIMRFGGKLLSKVRMSAISYSDVILGGALFTNIISLLIPLELYRLTRVTFPHMKAQRAALPVMIMLACTPSPPSLIAPYTEAVYAPLSLMLARLVKEEKWGRAYVVAFLAGSVRANGFFLGGFFIYQALLFPLLEKRQIPSNLVSRIIITVLGLLASFAPFVYTQFEAYQRLCPGDDFCNNFIPIAYNHVQKRYWDNGFLSYWTLQQIPNFAISFPIYLMSFRALKEKITLNTLPHYILHLVIILTLLFYSNVQIALRFSTALPLLWWHVASNENEGIPKAFIMWSQTWSVVSCILWSVFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6C5</accession>
    <name>I4Y6C5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_30317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960442.1">
        <property type="nucleotide sequence ID" value="XM_006960380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6C5"/>
    <dbReference type="STRING" id="671144.I4Y6C5"/>
    <dbReference type="GeneID" id="18471142"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30317"/>
    <dbReference type="HOGENOM" id="CLU_638103_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6C5"/>
    <dbReference type="OMA" id="GCLNEYL"/>
    <dbReference type="OrthoDB" id="3364397at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697435" evidence="2">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="46432" checksum="E811C0492B5511BA" modified="2012-09-05" version="1">MKFSLIAFMALGAAVMAAPVEKVADVDAQVNAISESHKRGLIDIDALINILSSSKQHKRGELVDADVVANVLSHQEQHHKRGGLIDIDALINILSSSKQHKRGGLIDIDALINILSSSKQKRGELVDADVIANVLSHQEQHHKRGGLIDIDLLINLLSGQKQKRGELVDADVIANVLSKQVQHKRGGLLDLDAGINILSGQQQHKRGGLIDIDALINVLSSSKQKRGEDCPEDQEGGEKKHEGGSLIDLDAGVNVLSKQEQHKRGELIDADVIANVLSKQVQHKRGEEGGKLVDVDALVNALSEVKQHKRGGLLDLDAGVNILSGQQQHKRGGLIDIDLLINLLSEQKQKRGEDCPEGQEGGEKEHKGGSLIDLDAGVNVLSKQEQHKRGELVDADVIANVLSKQVQHKRGGSLIDVDALINVLSKSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D6</accession>
    <name>I4Y6D6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960452.1">
        <property type="nucleotide sequence ID" value="XM_006960390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D6"/>
    <dbReference type="GeneID" id="18473051"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58695"/>
    <dbReference type="HOGENOM" id="CLU_2051467_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="12862" checksum="6F5245310F2FAFB7" modified="2012-09-05" version="1">MMFNIARVFSRANKPLQLSTISTSSRVLSKTQDKGVGVQEQSTPGGPSPDEIAQSDSAYDPSKPDPTSSAEGVEQETGKPFAGGTTAANPKGSPVASKLGDKNAKQSGNTLSGGRPHLDSTKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R7</accession>
    <name>I4Y6R7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_33917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960321.1">
        <property type="nucleotide sequence ID" value="XM_006960259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R7"/>
    <dbReference type="STRING" id="671144.I4Y6R7"/>
    <dbReference type="GeneID" id="18471774"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33917"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6R7"/>
    <dbReference type="OMA" id="MRELITF"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="452" mass="50619" checksum="9A2047EECBC0A445" modified="2012-09-05" version="1" fragment="single">MPRELINISAGQAGNQVSKNFWETLLIEHGLTNDGYVKPDTSDMQLERLNVYFNEINYQDKARYVPRSINVDLEPNTMEVLRQSKIGSLFSPSSFINGQSGAGNNFGKGYYTEGAELVDTILDSARREAEQVDSLQGFQLNHSLGGGTGSGLGTLLMSKLREEFPDRMMATFSIIPSPKVSDTVVEPYNAVLATNQLIENSDLTFMLDNEALYRICQNTLKSESPNYDSLNSLISRAMAGVSTSLRFPSQLNSDLRKLAVNMIPFPRLHFLCTSVAPLTSLQNRSYQSTNVQDLTASLFNNANKLAQLPKYGRYMTAAALYQGPMGMRDIEDSIMGYQSKNSDEFVEWIPHNVLTSHTSVSPIDSKTGGTFIANTTAVQELFNRNASMFSAMLKRRAYLHWYTGEGMDEMEFTEAESNLMDLIAEYQQYENAGADEEEYGEEEYYEEEAVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X1</accession>
    <name>I4Y6X1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_30161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960221.1">
        <property type="nucleotide sequence ID" value="XM_006960159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X1"/>
    <dbReference type="FunCoup" id="I4Y6X1">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6X1"/>
    <dbReference type="GeneID" id="18471131"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30161"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y6X1"/>
    <dbReference type="OMA" id="GSYEGWK"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="97"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="201" mass="22435" checksum="472728CBF2622E08" modified="2012-09-05" version="1">MAHELPQLPYAYNALEPFICEEIMTIHHTKHHQTYVNALNAAEKSFAEAQSAKDVKSQIALQAALKFNGGGHINHSLFWKNLAPAQSAEAKYPEGSAFAKAVERDLGGYENLKKEVTAATLGIQGSGWGWLALNSKNKRLEVITTANQDPVTPPHVPLFGIDIWEHAFYLQYKNVKPDYLNAIFNVINWAETAKRYDDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y788</accession>
    <name>I4Y788_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_30118</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960164.1">
        <property type="nucleotide sequence ID" value="XM_006960102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y788"/>
    <dbReference type="FunCoup" id="I4Y788">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y788"/>
    <dbReference type="GeneID" id="18471129"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30118"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_1"/>
    <dbReference type="InParanoid" id="I4Y788"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="195" mass="21721" checksum="41995DF95A43D488" modified="2012-09-05" version="1">MASLIGKQAPEISGTVVREGLFEEVSNKTYEGKWLLLFFYPMDFTFVCPTEILAFNKALPRFQELGVEVLGASTDSEFTHLAWSNVPRNEGGLGPDLKLPLLADKSHKVSKNYGVLLDDGVTLRGSFLIDPKGVLRQITVNDLPVGRSVEESIRLIKAFQFTDVHGEVCPADWNPETNNSTINPENKSEYFSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H2</accession>
    <name>I4Y7H2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_48380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960055.1">
        <property type="nucleotide sequence ID" value="XM_006959993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7H2"/>
    <dbReference type="FunCoup" id="I4Y7H2">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7H2"/>
    <dbReference type="GeneID" id="18472450"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48380"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y7H2"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="229" mass="25995" checksum="8EAF4FEC622827E7" modified="2012-09-05" version="1">MKFAVSSEPLFKSAHNEIKMPVNRSRSSNLSSEDKPLVWVDLEMTGLDMNNDHILEIAIIITDGELNKVDDGISLIVKRPKTVLDNMNEWCISTHGLSGLTKQVLTSPFSHQTVSKVAYEYIKRWIPDPRISVIAGNTVHMDLRFLEMDAHKEGWSRIASHLGYRVVDVSSFKEIAARWYPTLPLKSKKTSKHRALDDVQASIDELKYYRQSIFKPTERSVDVVTAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7K7</accession>
    <name>I4Y7K7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960087.1">
        <property type="nucleotide sequence ID" value="XM_006960025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7K7"/>
    <dbReference type="STRING" id="671144.I4Y7K7"/>
    <dbReference type="GeneID" id="18474429"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61268"/>
    <dbReference type="eggNOG" id="ENOG502S0C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029637_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7K7"/>
    <dbReference type="OMA" id="SWKPAYL"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="273"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="474" mass="53547" checksum="AA49943AA5CF909E" modified="2012-09-05" version="1">MTSAPPKSDDNLNDSFKKSQRRLSQSILEPLQDSPPSPTFSKHPYLSADDEAEGDLVSEDEASVSGTNMATQVNTSSEPPINEDNILRNGYLEKKGGGHRKRWKTRWFVLRPTKLAIYKSDKEYRLLRLIDVNVIHTCVEVDVGKKHQNVFGLVTPDRIFYLKAISRADMESWIEAINLARKLMRDQLSLQTSFPHNDESTTQLSPINIPVSPSVHRRTSLSSTQASPHRVDRPFEQSGFSLPTDGGESPNDRDSSDDDDDYHGILSPTDPNKVILTGYLMKLSKRKAWRKRYWILTSDKLSYARSHMDKPQRHIPLSKILDSLEAEEHVSSPEGTEQREHKFKVLTVKRTFILSAQSEEEEIRWLSALQTLLAHKRGLPVSDITASPMSSANNPQYLGPPPPHVTTQPPTPQTHKLVDVPEEESSAEVLVNEEDQDDNNNTRHKRTRSGTVEARAAVDAVTKRYHPEDKDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L9</accession>
    <name>I4Y8L9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_20659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959568.1">
        <property type="nucleotide sequence ID" value="XM_006959506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L9"/>
    <dbReference type="FunCoup" id="I4Y8L9">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L9"/>
    <dbReference type="GeneID" id="18470848"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20659"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034562_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L9"/>
    <dbReference type="OMA" id="SIHYRPY"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated" evidence="5">
        <location>
            <begin position="272"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="383"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated zinc finger" evidence="6">
        <location>
            <begin position="641"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="79778" checksum="F1528A67B61BC06C" modified="2012-09-05" version="1">MFAKPYLYVHLQPSGNDYSSVLNLYSSYTLDLVQEVSIKECKLLQAVNSTLYLDTDEGISNTQLVSWKDLVDRSTKEGKFEEALGLLESVGFTQDQSSDNNQEFQEFRLKILQLYSISLVDADEIDDAIDVFIELETNPAKVIALFPENISGRLYIPQENWNSIFGDFAKLYKGTIDNNEIINSTSMSSLRSGSDTASLKSNKVSRNSKIEALLRYLTDRRQKVKGAIHQHPSESFINVKLTDYTKEQLLELPSRSADTLNVDQLAVLAGVVDTALFKAYIETRPALVGSLCRLENYCQPEEVEQSLLDRKKFDELVSLYKSKNMHEKALDLLKGLTLDEEEGKDIDSSVSYIQQLGSEYIDLILQKSRWMFDVDKQTAIQIFIADDERVESLPKLRVAEYLNSFDIGLGLQYLRYAIKELNDQDPSLHNYFADTLLQAVLRNRKTEEFQTIYDAYLDFLRSSHQYAPKARLKAIPIDDLYRARAILVDRLGKYEDALRIYVKNLNDFDSATRYCVKVEKEDKEIFSKLLKFYLKGDKSTSPGSQSSYFKATAISPSYSTMSDEGDNMNEIISLLCNFPTKFDIQQVLQSLPGDVPLQELQRFLLRNYKATSSNQRWGSVVSNIRKSENERLAMKLVDLESRYVVIDDNRICPECKKRLGNSVISVHSPNGQVTHFGCKDNFTMKLQKIRRYDIYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N0</accession>
    <name>I4Y8N0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_39995</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959579.1">
        <property type="nucleotide sequence ID" value="XM_006959517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N0"/>
    <dbReference type="FunCoup" id="I4Y8N0">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8N0"/>
    <dbReference type="GeneID" id="18472147"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39995"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N0"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="404" mass="44482" checksum="0DC155D41626592E" modified="2012-09-05" version="1">MLFKQFNKLTTFNHIRKFATQVSQFTPATLHLKSGQSFTGKAFGADKSSFGETVFTTSVTSYTESMTDPSYKGQLLVFTTPLIGNYGVPLNPSGKDGRYTPEMFLESSGIQCSGVIVADVAEKFSHYEAVESLHDWCKRHNIPGITGVDTRAITTILRDQGTTLGQIAVGESHKQSPEEYFDPSPINLIAEASTKEAYTLNEQGDVHVAVMDFGSKANIIRALLKRNAKVTVLPWDYDFYSARDNYDALFLSNGPGDPRHASVAVENLAQTVKEWKKPIFGICMGHQLLGLAAGLEAYRMTFGNRGHNQPVLALSESGSIKAGRVYVTSQNHQYALKLEEQFPDGWEPFFINCNDSSVEGIKSTDKSGKQIWGVQFHPEAFGGPLDTIDMFTDFVDAAKKGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y929</accession>
    <name>I4Y929_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">WALSEDRAFT_60933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959497.1">
        <property type="nucleotide sequence ID" value="XM_006959435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y929"/>
    <dbReference type="FunCoup" id="I4Y929">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y929"/>
    <dbReference type="GeneID" id="18474262"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60933"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1062472_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y929"/>
    <dbReference type="OMA" id="GHHGRFI"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="262" mass="29896" checksum="674618458D028AFF" modified="2012-09-05" version="1">MSEEIDLSSIFWRAPEFLQYYGNTLNDALIMDYFSLSPFYDKKSNNQLIKMQNIANLSQPANIFDQLVHFTGIEFVLAHSEAPDLFIINKQYRHSPTDSRVLAVYYCLNNNIYAAPDGYNALGMKFHSAIFALQSSMKTLRDNLPAYNPRVGYSWQIEPNKQKDKTDVTEENSIPLLKSLRTTRADLKLERERRAKLLSEQTGEKIDIDQTDQTVEEPKPVPTKSAPTDTIKKKKRKSTKSSATSRSSTPATPDILNMSKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9B8</accession>
    <name>I4Y9B8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959354.1">
        <property type="nucleotide sequence ID" value="XM_006959292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9B8"/>
    <dbReference type="STRING" id="671144.I4Y9B8"/>
    <dbReference type="GeneID" id="18475625"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69712"/>
    <dbReference type="eggNOG" id="ENOG502S8NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1541310_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9B8"/>
    <dbReference type="OMA" id="PRLNIMA"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19493" checksum="E0BF6496F4131738" modified="2012-09-05" version="1">MLDPSIYLQNQGWKVGRGLKENSISRPIPAPRKRNLNGIGRDRDDGHLFHSSLFDAAAKAIQIKIDDSSDEEDSSEGDKDTKSQSLSISRTSTGIISTRTSTPSVPSTEIAFGQAKQSIAKRKLYSRFRQGQTYKGGELQEFLQDNKQRVPVQTEAKKSKKKRKSPDNPWMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9J9</accession>
    <name>I4Y9J9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_52084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959424.1">
        <property type="nucleotide sequence ID" value="XM_006959362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9J9"/>
    <dbReference type="STRING" id="671144.I4Y9J9"/>
    <dbReference type="GeneID" id="18472575"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52084"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y9J9"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36032" checksum="975A4AF755339DA9" modified="2012-09-05" version="1">MMRARNVRLFASHSNLNTIPKPTPSIFNVFDRETKIWQKDVAASNVSQSRVVDYIKNEIGESFRDRLLDIKRRYNKAICIGSGSNQVARVLDEEELADDIHIADSSVLRDKEFDSDFASKFLSYIEHPSMNSLFKTNSTDIIISSLGLHWVNDLPGALIQFNHALKPDSPFLGCLYGGDSLFELRTSLQLAEQERWGGFGPHVSPMTDTTDVGNLMNRAGFTLLTIDIDDLVINYPSMFELIEDLKFMGESNSINGRRAHISRDTLIAASEIYKSLHGNEDGTIPATFQIINVIGWKRSDDQLKPLKRGSATRSMKELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N6</accession>
    <name>I4Y9N6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959211.1">
        <property type="nucleotide sequence ID" value="XM_006959149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N6"/>
    <dbReference type="FunCoup" id="I4Y9N6">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9N6"/>
    <dbReference type="GeneID" id="18475607"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69605"/>
    <dbReference type="eggNOG" id="KOG0718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019611_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9N6"/>
    <dbReference type="OMA" id="QLDKHTM"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="600" mass="67773" checksum="4A7708EB8C3DD7D3" modified="2012-09-05" version="1">MDGLYNLTEWQNVHNENFSDRNEPIEKELDYEVDKDIDNNNESYRDYYSILNLPRNATNEEIKDRYKQLAIIFHPDKQRSDHQREAAALQFSHIKHAYEVLSDPHKRMAYDTLGEEGLKNDWQVGQRLRTPEEMREEYERRRRVNELESLESVLRSKGDVNVHIDATSAVADAIGVEKTPQLNMLGNPVLEKTGLTNSLAGIAVRRLVMQHSFECPITRQTQLVVLGQMVSKANTGGGNVMGTIRHFYSPKLSLTATQTFLKPQFTQLAGVYEIDDDTSLQLSSMHPDWRLFPQVNLTLSRRVQETVQAFLSLRLPSPMGPSSLSVGANGLTHGRSASSWSTSLVFGPVENGLGLEWGRRILDNTIRFRVGTSLSMQGIFNSFAWAERKITRATTIGFGITCSLPGGVIARFRWSRLGQRITIPVLLSRDLDLAVAALAAAIPSATMVALHYSYLVPRNKKLKAAKLKRLAEEHREKIAEKKSEAEDAITILKDHAERKEADENAKSGLIILEADYGSSENLQNNERIDVRLPLMALVNDGQLYIPKGTSKAGLLGFYDPCLGEKKNLHLKYQYQLRIHEVTVKDKEEIALPQRDHLVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U4</accession>
    <name>I4Y9U4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959267.1">
        <property type="nucleotide sequence ID" value="XM_006959205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U4"/>
    <dbReference type="FunCoup" id="I4Y9U4">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9U4"/>
    <dbReference type="GeneID" id="18474185"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60820"/>
    <dbReference type="eggNOG" id="ENOG502SEMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185819_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9U4"/>
    <dbReference type="OMA" id="SPAHESI"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22344" checksum="AE533881C72ACA1C" modified="2012-09-05" version="1">MAALNNSMVNEDGTKPVEFPEEKITLSYDDVQLRLSISSAGKVYDARGSLFLSNKRIVFLSPEHESMRSLSVLLEYVVDGVLAQPLLGANRWEASILPSREPQTNEEPNILANGADLKAWFNNGSTFEFYQGVEEMRERQGNYNNAPQYEPLPQYESQQASNAPSPSYEAESASMDAAITSAQADEEQSRQLQSENPPPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W1</accession>
    <name>I4Y9W1_WALMC</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_20010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959174.1">
        <property type="nucleotide sequence ID" value="XM_006959112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W1"/>
    <dbReference type="GeneID" id="18470820"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20010"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y9W1"/>
    <dbReference type="OMA" id="HFFIVPE"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="520" mass="58870" checksum="930BD618C03462C1" modified="2012-09-05" version="1">MTPEDVTDKEELYFEKKTADGRIVLTEDAAYEATAFAYSSPKKWYILTVIAFIQYSMNFNTSVYSNAVEGMSEEWNISQQAARVGQMIFLVAYAFGCELWAPWSEEYGRWPVLQLSLFFVNIWALMCSLAPNFGTMVVGRFLGGLSSAGGSVTLGMVADLWPAETQQYGLNYVVLSSVAGSAIGPIIGGMSKKYYRISADMFRWTFWIQLIWGGAAQVIHFFTVPETRCSILLDKEAKRRRKEGRTSYYGPNEVITNRITVKSVCDIWIRPFRMMVTEPIVLFCSLLSGFSDMLIFIFLESYGPVFQQWGFETYQVGLAFIPIMVAYFLAWAMFLPWIRRDELKRRKDPNSVNPESRLFWLVCTVLLEPIGLFGFAWTSLGPSRSVHWFGPMFFAALIGIANYNIYMATIDYMVLAYGPYSASATGSNGFARDMLAGISAMFSVPFYEYFAEPNTLTYPTTILACIGIVVAIPVFFLYKYGPQVRKASKFAQVLAAEKESTAVKHQIREEKSHVKHTEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA04</accession>
    <name>I4YA04_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959061.1">
        <property type="nucleotide sequence ID" value="XM_006958999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA04"/>
    <dbReference type="FunCoup" id="I4YA04">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA04"/>
    <dbReference type="GeneID" id="18475589"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69481"/>
    <dbReference type="eggNOG" id="ENOG502S8KV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994666_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA04"/>
    <dbReference type="OMA" id="THNTRKL"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31227" checksum="B981A4A37C11ABFB" modified="2012-09-05" version="1">MSSAQFLELNDVNEAPENKRDKKRRDLVEKLNKQSAEIYDRRDLIFLEAHNAMTDVHNHLLSTSPTNPYEFTAAPSTGSLMTSREQNLRLYELSLERDAILSAIKHTYGYAMDSAKSLYEIERSRVEEEYDSVQRSIKTKLIDAIEEKKRKLKEEKDMEVGVESLLDATNFSRSTRTSRNRKSGNVSSSVGGTPSQQDPNESEATVPSSSYLGVAFEDILGSSSLNSVLGGKKKKTPAGPPGMTGPFLGLGRSINSGLTAAKDIDVDTDMMEIRKKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA36</accession>
    <name>I4YA36_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Blue (type 1) copper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_39300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959090.1">
        <property type="nucleotide sequence ID" value="XM_006959028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA36"/>
    <dbReference type="STRING" id="671144.I4YA36"/>
    <dbReference type="GeneID" id="18472110"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39300"/>
    <dbReference type="eggNOG" id="ENOG502S66W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839931_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA36"/>
    <dbReference type="OMA" id="SKNAIIM"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697881" description="Blue (type 1) copper domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35491" checksum="8B5CA499FC4334DF" modified="2012-09-05" version="1">MQFKLIVTVASITALASASFVPLNVARSPQYDYNAAPAPASVRAGSGYDQCVQQCNTNWDKGSVENTDGYGNDNGKNSTAPSQTTKHIIVAPSQGVLRFVPFAMQANVGDKIQFTWMANNHGVTKSSMTGICNATMDKPFKSPVQNSSATFETTVDTTDPMFYYCPVGNHCTSGMYGIINPPMAPTNLSNVGDAMGKWEKDSKNTIIMKNADDIMKNANMTSEQLNWGNGWMDMSKNEDDLTAMIENIIITRLTIALNPGWTPGAPVDMKTFKAPPTINNLAATSYGDSPTTSNAAPEATDEAGSNSSGCNKFGIQIFTFLFSLIAASAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA77</accession>
    <name>I4YA77_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_39356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959129.1">
        <property type="nucleotide sequence ID" value="XM_006959067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA77"/>
    <dbReference type="STRING" id="671144.I4YA77"/>
    <dbReference type="GeneID" id="18472113"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39356"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA77"/>
    <dbReference type="OMA" id="NWYGFNV"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="485" mass="53138" checksum="CDE15AB289C8D63E" modified="2012-09-05" version="1">MTQTSTPLVENWIDNGARKSTDDNLYVVQHPNTHNQPHAVVSASEEDIDRAITSAHLAFKSWKKTTHDQRRDILLKAAQILRKRKDDVYEAYSSELDVNHHFVDFLVGITSSMIETAATLIIPSLTGEIPPTKRDNEALYLCEREPLGVCLALAPWNAATNLSIRAIVNPLAAGNTVVFRTSETTPKTHAIWGSIFKEAGLPDGCLNIVHTSRGNAPAVTERLIADDRIRHVSFTGSTNVGRQIGKLSGYHLKPCLLELGGKCPVLVLNDADLNLVVNQSLFHAWVNAGQICMATERVLAGGSTYDKLIQTYKDNAPENASSPVAMASSHQRIVGLVDEALSKGAELVIGNWPPSKEDVESRKIPNIILTKVTPEMSIWTEETFGPIAIVVKVEEKQGENEDEAIVRYANESRYGLAASIYSKDITRVLKLAKEVEVGLLRINEGTIGDESVCPFGGCKDTGFGRFNGVEGIREFTQIKTYSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAB4</accession>
    <name>I4YAB4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959165.1">
        <property type="nucleotide sequence ID" value="XM_006959103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAB4"/>
    <dbReference type="STRING" id="671144.I4YAB4"/>
    <dbReference type="GeneID" id="18474155"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60774"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005431_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAB4"/>
    <dbReference type="OMA" id="SCFAQMR"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="408"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="660"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="957" mass="107957" checksum="E0D3C5B1E26662A9" modified="2012-09-05" version="1">MEPLGPQLRKHPSSDDLLRDFKNEIDSSNPPPAYQATQHPYANTNSSLLKQKKAFEDSIGGGWDKLADDKLRDSYYDDSFDSHTPYQPLAPPQVQTRPRSHTQSTMLDSSAASGFSIVVLGSQGVGKTTVIRKGFRKYGLSSATLLSPPEKGKCQSRQSVIEIHGQPKNAIIYEIGFAGLNFKSPEIFPEYVQSIDAAIVCYDSTDESSFIGIVELLHRLSEMGLPRVVLATKSGEVFPGKPTINPNTVVSIIRQLDTGLIETNALSTDGRRRMRGAFDWIFRNIRKQRKEVRDRGLSNSSAYSAVPHQFTQIPLSPEEQSPEQLQGAKLIPPGVHNDTLRMSVSSAECDAIMSEATRGLVDVNSPTYSTFNGFSNHLYDTFSDSDIDEKATEVNYGRPSLLRNFTNDNDNSRFVTLHDLLNKLIFAAVSGNDQEFVKSFFSTYRKFTRAYVVLQAMLTRFDEVSRDCDSVLVTFTQSRLLTLLDRWIRHYPGDLLSPLHRHLIQEFFQRATSNINVIHYAPILKAHLDRPRATYDPEFKWSADEDDYEKEFQMKVNQSEIQFEDSDLPLALSFKRKSNDAGVIVPDGSSEGKTSRRGSSAFRTWTSRQRSDSDASKVTTSSNNGPASLSSNSSTGVPSQRRRTIEKIALAILDPVLPLKPVEMAHELTRIEWKLFLNINDRDLLRHALLTSKDRDEDSIDVQIRHFNYLTLWVANLVLSQTKPKSRLKVVEFMVNMAEELRNINNYHTMHAVLSAFDVHSIFRLMNNRVIDLESNEELFMKFKKLKLIFTSDRSSATYREVLRNTPCPSIPYLGVHLQDILASDTANVNIKKGPNGENLIHWSKFALMGEACKQIMKRQKYQHDFTYNAKANELIMDITLLDEDELFQRSKHLEQIHRSSYGGPGQAMISASASTFKESLKSASSWSNNISNPENNGSNDKKFLKLVRTAISSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAM2</accession>
    <name>I4YAM2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">APC amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959000.1">
        <property type="nucleotide sequence ID" value="XM_006958938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAM2"/>
    <dbReference type="FunCoup" id="I4YAM2">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAM2"/>
    <dbReference type="GeneID" id="18471599"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32982"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="I4YAM2"/>
    <dbReference type="OMA" id="KSYLAMP"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="97"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="610" mass="66024" checksum="04B97AE179F5CB63" modified="2012-09-05" version="1">MLNDEEKIVGLSSASPKIEDKKEGSYTPDVSNAPEVYDPSQESFLTRLGLTFESFKTAPATPARVAVATDSGEIAQEEIEGAASDGVLHKNIPGRSLQMIAVGGSIGTGLFISTGGALSDGGPVSMIIGWLILAVTLFCVINAIGELAILYPAEGGFYAMANRFIDENVGYAMGMLYALQWVVVLPTELTAIAQTIQYWDGEIFDIKTSNAVWISVFFVIVILINVFGNKAYAEEEFWSAIVKVAIIILFIVAGVVFNCGGGPSSGDYGQYVGGEYYRADGLHNGIVNGFKGVCSVFVAAAFSFAGSELVGIAVSEVKDPVKVMPSAIKAVVWRIFIVFFVSIIIIGVNVPYDDARLMSDDNPSATSPFVIMMNKSNVLGLDHLMNVIILLSCLSIALASVYGGSRTIQAMAMQKFLPRWCAKVDKAGRPINAVFVSLLFGPLAYLALASNGSTVLDWLIAVSALSTLFTWLSICACHIRFRSAWYKQGHTKDEIPYRSSAGIIGSWFAGFVIILILIAQFYIAVFPIGEGGMDGQERASSFFQAYMALPAGILFYAQSFLIKKTFPKSSKDIDLDTGRKVFLTADYLNAQRQARKNAPIPKRIWQTLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR3</accession>
    <name>I4YAR3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959041.1">
        <property type="nucleotide sequence ID" value="XM_006958979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR3"/>
    <dbReference type="GeneID" id="18474105"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60696"/>
    <dbReference type="eggNOG" id="KOG3870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030117_1_1_1"/>
    <dbReference type="InParanoid" id="I4YAR3"/>
    <dbReference type="OMA" id="SHFWTGP"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="68"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="56572" checksum="FE0F0A08A35D9551" modified="2012-09-05" version="1">MQTPNGSVDVPNPSIPSSVQLRLKNMPPRSRSYMAEPNKIDAKYVNPESPPFPAFRGYHTFSFANDVMGRRLPTILGKAIEDTIITLNQLSSEDEILDLLACIERMDILMDDLKGNKKLTPIPDDGAGDIAIWNKEIAKYFQGKDFMSAPWIFAEAYKYRRLHSCFSVSRYFQDYDVFFRQKCDTFARSGHAVFELATRFAEPFDIPNDDAKKLIFYELFQVCLWGNSTDLSLLIDMSEEDIKNLQSTGGDQLAATQKNILGNDIDKVWNQLKNSKNGRIDFVLDNAGFELFTDLVLADFLIQSGLANQVKFHGKRFSWFVSDVTKKDWEWLINSACYGRLFKGSPEELNALRALGQRWKRYEQEGKLIYEQHPFWISGYTFFHLLEVSPDLFLDLHQSKLVFFKGDLNHRKLTYDCRAPPTTPFSEAIGTLASAPGAPPVCSMRTIKSDVVVGLPKGVAEKLDQEEKDWRLSGRYSVILMSDGRPEEDVDFDYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT0</accession>
    <name>I4YAT0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_38769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958757.1">
        <property type="nucleotide sequence ID" value="XM_006958695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT0"/>
    <dbReference type="STRING" id="671144.I4YAT0"/>
    <dbReference type="GeneID" id="18472079"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38769"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547689_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAT0"/>
    <dbReference type="OMA" id="CKRFTST"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="428" mass="48140" checksum="501D744C7B0F9946" modified="2012-09-05" version="1">MNMNMSLTNANSADSSQPASWVSRRTGNMSLVTSDTLEKSLSLKAAKEKEIATKKAQRLARKSSKRKKHQSITKDGRRQIIIDGVPFEFDETGGKLVKVAKEDNDTFNDEPQQSVYNIMDDDTNNNNNTPKKMTIDGTNYVRTKSGNLVRDIFAKKRNEEAMKAKQQRLDKMVGMLGSVQRARNTQIQRKPHNKKEVLSEDQKISFGRKRCPTFTKSGRCSKALHCPYVHDSSKTAICPHFLRKKCRNSDSSCPLSHTPSPNNMPNCSHFESPNGCRAGDECLFTHVHLSKDASVCRDFAVLGFCDKGLDCDSKHVRECPDYAENGECKNPSCNLPHILKSEANKVGVIDEFTKRKEVEEESQEEQDESSKPTFKRRKNQHDDLTEQSDFVTFDDSGNSSDSADSVDSDQESVNSDDYNLANESIPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAX9</accession>
    <name>I4YAX9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_64706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958798.1">
        <property type="nucleotide sequence ID" value="XM_006958736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAX9"/>
    <dbReference type="STRING" id="671144.I4YAX9"/>
    <dbReference type="GeneID" id="18474951"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64706"/>
    <dbReference type="eggNOG" id="ENOG502R4GW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007382_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAX9"/>
    <dbReference type="OMA" id="MINGMMR"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697903" evidence="1">
        <location>
            <begin position="18"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="331"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="491"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="682"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="967" mass="109357" checksum="96F6D11A67FC3E02" modified="2012-09-05" version="1">MRTTLAAFLLIVYQVLANSQVLFDNDNNLYVLGVNDKDFSAGTKKEWNSSKSFSKLNKGDKPSFDTTAPNCWLSQYNNGGYCLNVDNSNKNSIYILDFSNKEWKKYDMEGDLPDFDKLKAVLDHDTNVWYGVSDKNLYSLEMGEDLLPDDTLTWKKVQEVPFDIDDNVVIGLASNHLHFINGGGLDKGEAELFVIHYSYFQPEEQKYGDFEQSKGQAVSVFKESKEWQTKFWFLPENLENSYLIDVDKNTTETYEGPSNKDANSAFTSNDQTLVQLTSANQLYYLDFSSGNSAEWKQIENTALPLPTNTNEEKETSNSKTTNINYALIFLKSLFDILTHLQSFNEFTSTKIPGRVSSSGYPFKPIENLEQPPSPALNYLFNQLALSLPGFNTISPELWQEGAQGLLERLAAQDLSDSFDKGLLGKRKILGQGIIVIAEFALRGVLGGLPKRKQSTYPKDARECHYDLENPIDVQNGWNDFLQGLVYKDYVRDVVNYVETTSNLEDLPLLYQAAHTFASATLASFLHYLFTRSPCAQSTVLLISRVHNLLPYSLVGVSTQVANAATMISGVLKIFLSRNPLGYVGIGNGNNLLQTIITSVLGKDKSNLQKQWQSVEKREAESGATDQQKIAIQKYVDDASREDRIDIRNESIEKNQSIIITILERNDVEAPISEEAHSTLLTQLTLQLAIRDRYRLIDALVHTKPDLVSLCVTEAMNAFEPLIRKLHKSVNLKETLDDLQIFIDDLVKIAQDKAGPRSYIALFDKHQKNLHKFLHNLVKNAPEMKEMYLEWYLHSLKQYRTESEEENQEDCAGAGDFSPVLQELFDKLDENTQKEVVKELDEHVKYQENVSESSRQKLVDLLDKTRPEPDIGPGVFIAVWQDMIDKNPITPVTMHGTVRHGADKGVLQASNVGIENQEEIEQDIMTSNSKARAAPLYGEGTIRPDCSKTIETLQDEFDLCLRQRHGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB06</accession>
    <name>I4YB06_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_51687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958822.1">
        <property type="nucleotide sequence ID" value="XM_006958760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB06"/>
    <dbReference type="FunCoup" id="I4YB06">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB06"/>
    <dbReference type="GeneID" id="18472566"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51687"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_3_3_1"/>
    <dbReference type="InParanoid" id="I4YB06"/>
    <dbReference type="OMA" id="NGEVHKM"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="167" mass="18915" checksum="3F72ED19E3BD29C0" modified="2012-09-05" version="1">MPEGTRPLIVGPEPIAAPFPLKMQGLVQKGFGRGSKELGIPTANLPEESYCESFKLLDAASNTGVYYGWAKVDGVDNDEVHPMAMSVGWNPYYKNEKLTAEVHIMHPYNQDFYGKNMRVIVTGYVRPEFDYSTLEALIEDIEFDKKVAIHSLDRDSYKELKQDAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB68</accession>
    <name>I4YB68_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958882.1">
        <property type="nucleotide sequence ID" value="XM_006958820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB68"/>
    <dbReference type="FunCoup" id="I4YB68">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB68"/>
    <dbReference type="GeneID" id="18474066"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60630"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_1"/>
    <dbReference type="InParanoid" id="I4YB68"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="451" mass="48763" checksum="D61D2ED18CA9A58B" modified="2012-09-05" version="1">MFSIRNFRLINNRRSLSTAASGYIKPTHPDNPQPKEVIDKLNRYANSVVNTYARPPVIFTHGKGLKLYDSQDREYLDMSAGIAVNGLGHADDGVSKVLADQSSKLVHNSNLYHNEWSGELAHLLTTLTKQHGGLGYVKGSSTEGAGLKAFFANSGTEANEGALKFARVSGKQHSADKVELVCFNNAFHGRSMGGLSVTSNPKYQDPFAPLIPGVKVGNVNDVPALTELVTEKTCGVIIEPIQGEGGIHNVDLDFLIALRKRCDEVGAVLIYDEIQCGLFRSTNMWAHSDFPVEAHPDLITMAKPLANGFPIGAILMRDSVANNVSPGSHGTTFGGSPLSTAVAHHVLTRLSQLPDMKSRAELLKERLNQLAAAYPDLIKSEVRGRGFLLGVPFKDTAHPGKALSLARERGLLILVAGSDAVRIVPSLTISEEEINKACDIFEAVLEVLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC9</accession>
    <name>I4YBC9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958624.1">
        <property type="nucleotide sequence ID" value="XM_006958562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC9"/>
    <dbReference type="GeneID" id="18471547"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32723"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="InParanoid" id="I4YBC9"/>
    <dbReference type="OMA" id="MTWIACA"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="516" mass="56849" checksum="8C3F250C4566F70B" modified="2012-09-05" version="1">MPAYDASSKISSFKNESTITIPIEDEKKYLVEFTPNDSDNPKNWSGLKKWSIVFAITLINICTGLAMTVYASIGDTLKRDTGASQLEYISGMTTFMIAVSLLPLILSPMSESFGRRQIYVVTGTLHALLFLPQILVKNIAVIVVMRLLQGACSSVGNTLVGGSIADMFDASDRGLPMAVFSLFAIGTQGVGPSWSGYTQMNLDGVGGFGGWQWALWITFIINCISCIVSILFLKETRGNIIVKHRANSLKKKTGLPYYAPDTAKFNAAGIATSLKRSYQLFVEPIVFALSLWCGFLWGVVYLILAAIPWTFERAYHFNSGQSHLVLISITIGSVIGFLSNFHQQSVYRNRAARSTNNKCAPEVRLYWSCAGGLLFSIGCIIMAWTTTRDVHFTIPCIFGLVTLIWGIYVVYTALFNYLSDCYETYASSAQAATSAFRNFLGAIFPLFSMKMYEGMTAPWASTLIGLLGFALSIIPFLLITNGSKIRARSKIASQLAKEEREAERSTFRNIPTLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBE7</accession>
    <name>I4YBE7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958642.1">
        <property type="nucleotide sequence ID" value="XM_006958580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBE7"/>
    <dbReference type="FunCoup" id="I4YBE7">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBE7"/>
    <dbReference type="GeneID" id="18473994"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60506"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_5_2_1"/>
    <dbReference type="InParanoid" id="I4YBE7"/>
    <dbReference type="OMA" id="QNAQNLW"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="28"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="301" mass="33708" checksum="56B23E904490DB92" modified="2012-09-05" version="1">MTDVQVTTEWIAAQDDVELYSKTYSPAEPKALIFFVHGFVEHIDRYTLIFPKFAQAGYKLFAYDQRGFGRSAHEKSGNPKPGLTSWKYGLKDLQTLIFRFAEQNKGLPLFLMGHSMGGGLVLGSQTRNPPLNLPELKGVIAMSPLIKLTNPPPNLLIKMVQRCKGLLGSFTISPMIDPKDRTHDEEVQKAIEEDVLASKIGTLRGVSDMLYNGPLLLSNNYKFYQANIPLLIAHGDADNLNSFEASSQFIDKVMARSKQLKTYPGARHELFMEAGELKYEVARDVIAWLNNVMDEPTPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBI9</accession>
    <name>I4YBI9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958679.1">
        <property type="nucleotide sequence ID" value="XM_006958617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBI9"/>
    <dbReference type="STRING" id="671144.I4YBI9"/>
    <dbReference type="GeneID" id="18471555"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32767"/>
    <dbReference type="eggNOG" id="KOG0946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301518_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBI9"/>
    <dbReference type="OMA" id="GQETFCN"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="184"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="668"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="89709" checksum="94BD5E9AB6A9F57D" modified="2012-09-05" version="1">MAKNGLSNLIQLLDYSNFIRSETLIILLYITDYNSELQKIAAFEGIFDKLFKIILSEGSIDGTIIVQDCLHCIQNLLRYNSSNITFFREMGFVKNLTHTLLYSPDNLDSFSLQYWSEQKVVNAAIVIDIVRIIAGLGNRQGNLSILQSGLTQCLIDLSLSSNAPVTLKAQTLTALTAIFSTSPQNQQFFTQSQTQPILNSDAYAAGYLRLPPRLATISLIDIALNGESGDENRMVDDVDSLKGHNLMFQVAALSAFESLITSNDSLKLEIIASMSHTTNEVNYDGSITHTAGSLLLEALSNLPTPEVSLDGAFDSQKVFFASLVLSHVLRYSEDARAMARNIPFNPSEDTDEDETVSLLHGIFGNLITCSRERSAADARLREKEFSSINRTEEPEKQGNQENEEEEVKQIDIDWTRLTVSYLILLSVWVWDSPATVSDILKESSNLQVLIQPIKQSSGVDALIQGLCAFTFGAIYKFNTGPSEVSKKDLHSIIEKQIGVDNIIQSLARFRSDKRFCKIGSPDDALAYAETPQEDGWWFDWNYVEFFKGSFMAVQRSVISEEIEETTKVAPPLPQASSPLPESTDNTDHEKVVQEKDSQIETHKQRIEELKVKNANMEMEMERVNNELGEAKSKLQALWEQGSPEVAGLRGDLAEGVKREETLRAELDKLNNELETLKQKEGEHKSASGELTTKIEILENEVKSNKEEVLRLKEQNDGLKSTNERDTNEIQSTKNTNETLQKENEHLKTQLEKHIESEKEHEDLLILLEDMSTKRSNDKNRMKQAGLEVSEDEGDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBN6</accession>
    <name>I4YBN6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methylbutyraldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Gcy1p</name>
        <name evidence="6" type="ORF">WALSEDRAFT_28998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958724.1">
        <property type="nucleotide sequence ID" value="XM_006958662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBN6"/>
    <dbReference type="STRING" id="671144.I4YBN6"/>
    <dbReference type="GeneID" id="18471069"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28998"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBN6"/>
    <dbReference type="OMA" id="MHSPMGI"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="32990" checksum="00F90AB85CE93C60" modified="2012-09-05" version="1">MPTTSFKLNNGREIPSVGLGTWQSAPGEVANAVKYAIKDAGYRHIDGAFCYENEKEVGEGVKASGVPRSEIFLTSKLWCTYHTKVEAGLDETLAELGTDYLDLFLIHWPVPMNPNGHKRFPKKADGSMDTINDRPIEDTWRDMEKLVDSGKVKSIGVSNFSIANMKKILAICRIKPVVNQVESHAYLSQRELKKFCEENGVLLQAYSPLGSTDSPILKDEELLAIANKHNVSVGTVLISYQNNRGVIVLPKSVTPARIAANAQLIDLTPEEINTIETMEDRGKRLRIVFPDWASTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS8</accession>
    <name>I4YBS8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958451.1">
        <property type="nucleotide sequence ID" value="XM_006958389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS8"/>
    <dbReference type="FunCoup" id="I4YBS8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBS8"/>
    <dbReference type="GeneID" id="18473936"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60421"/>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097982_3_0_1"/>
    <dbReference type="InParanoid" id="I4YBS8"/>
    <dbReference type="OMA" id="ASKYSYW"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698761" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="55"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="20398" checksum="38AC24BD715D9DB6" modified="2012-09-05" version="1">MKLATTILLAATAVSASISAFEDNYLDVLSFDQSIVYLGDDATQKDVHTLSKWSWNDCGGNDDALKLTKIDVSPDPPQSGRNLTIDAAGIVNRYIAEGAYADVSVKLGYITLYHTRFDLCKEAHDADAQIQCPVEAGERAITQNVELPSHIPPAAYTLQVRANTVDDTPLACLNFRLSFLPFLSVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBT1</accession>
    <name>I4YBT1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958454.1">
        <property type="nucleotide sequence ID" value="XM_006958392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBT1"/>
    <dbReference type="GeneID" id="18471532"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32626"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="I4YBT1"/>
    <dbReference type="OMA" id="MFINGWN"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="580" mass="63760" checksum="CA20EF22C9B321ED" modified="2012-09-05" version="1">MDRDQNSSVHHSESDNSIKKDIINEDSLAHKRTDAEKQITDQTNYLPKSRIIMVFIACSSVDFLALMDQTNVAVALNTIASSLGSGSQSSWIASAYFLTSTSFQLLYGRFSDICGRKTILMIGLFIFFVFTLGSSLSQTMTQLIVFRALTGMGGGGLMSLCQVIVSDVVSLRDRGKYQGILGAVVALANGVGPVIGGAFASFQWRWIFWLNLPICAVTSAMVWFIMPLKKVEGSWKEKLFRIDFFGAFLTLLSTTLIILGLTWAGSEYPWDSAHVLGTLISGIGVAIIFIAWEGLFARIPVMPLYIFRCHRMVNGACLTQFINGYLFLTQTYYLPKFYQLAYGYSGVKSGAMLLPLSLVQTASSTLGGLLVTWIGRYREIVLLGWALWATGMGLLSTLDDHTGVDKQVGYSILTGFGVGLTLQASLVGVQAAVERKDMAVITSVRNFVRNLGGTLGLAISGTTLNTVFRSWMLANGLSESLIKTLINNPEEGRNNLDEDTTDLVISGYRQGFRIIFLTCAGLGGLSFILAFLLMPQISLDRDDDQKLKDEGRKWVEEGKNKKRMKKEGIKDEKLDTDTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBT4</accession>
    <name>I4YBT4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_28781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958457.1">
        <property type="nucleotide sequence ID" value="XM_006958395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBT4"/>
    <dbReference type="STRING" id="671144.I4YBT4"/>
    <dbReference type="GeneID" id="18471059"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28781"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430342_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBT4"/>
    <dbReference type="OMA" id="NHIACSI"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65788" checksum="B3EAC409883A1171" modified="2012-09-05" version="1">MHSIKLCLLRPRIGTSTKLIPALVRFNSSAGLVKAIRNRDLDKLQNELKNVNLGNINEEDIQNLSALAVTLPQSSSLDELSLVLAGRQQPKALLKVFKRALTSGDSKKVIDMYTRLDKDSVDTLTLLCVVAAYSLIGNYRGAQTAVENANKPGYTFNPKNTALHTGLTNDKLALAQDYISKLRFYHDTKTKADLISAIDNAGGNSMRKHLIDLYAAVDIATLEDDEIYARFIQAFTSASKRGSPPLPAHVLDKPYSKLGPKSLNAALQGAFVRSTGTTNVNNILNAMNAKNVLPDEDIASALVSDLISKDRKDAGMALFDTIQEMYTNSGQGVPTKICNALLSGLTKVGMSDVALDVFKQIKEPSIVTYNILIRYSVLKNDHATTINLLRELRERGITPDAHTFSMLLVYLRKRGHGEAINVVMKTMTDCGVTPDLHIYSGMIDILAKEGQLKEAITLLDRIEDEGVKTTSVTYTSVISGYLLHSSDGLQEAQKLMARMKLRGLSPTPVLFNYIIEASLASQNAYAPWVFLEQMQYEPNVHITKGTLYILMKGFYESRRYDDCKRLLDFIDRHDLTSLGDDALNRIINKIKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV4</accession>
    <name>I4YBV4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_38411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958476.1">
        <property type="nucleotide sequence ID" value="XM_006958414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV4"/>
    <dbReference type="FunCoup" id="I4YBV4">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBV4"/>
    <dbReference type="GeneID" id="18472061"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38411"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBV4"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="351" mass="39265" checksum="81746D22B99DECC9" modified="2012-09-05" version="1">MYATSSQVPLQHPVPQHAFKPPLTPDSLAKDSRGSLDSHPGYDSDPYNPSHYQNTNAQTDNIYQQQQFQQPQFAYQQQQYQQPFNLNDGTTQMGIQFGKSAFAAGHDYVDRNLARHLPLPIVKSLFNVSTAYVGAKLRLICFPWTHKRWMRTRNETFAPDGAPITAGYLSPRQDVNSPDLYIPFMSVVTYIILAAIYAGIHNRFHPEVLGGRASVSFAIALTELALIKLICYLLGVETGASAETGWSAGVSGSVELMSYCGYKFVSVLPPLAVKLFFPSWRFVYYAVFLYCLAAQGFFLLRSLKYVLLPDASSASAATLVSVGSSERRRRLQFLFIIACFQLVWMGVLVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBX4</accession>
    <name>I4YBX4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958496.1">
        <property type="nucleotide sequence ID" value="XM_006958434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBX4"/>
    <dbReference type="FunCoup" id="I4YBX4">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBX4"/>
    <dbReference type="GeneID" id="18475514"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69036"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048924_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBX4"/>
    <dbReference type="OMA" id="PLVFHNH"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="323" mass="36104" checksum="35EA47164E9E7D89" modified="2012-09-05" version="1">MMSLASVPRYTSRIGQRTAWVLSRQFASKANDGGNTSVSSQDVDSASTRLKARQLLNQLEDSRNRGNSAGPFGAATISDDVNAAPEKTFSEQTTFKGKVGRATKQTSRFTVILIGASVTGLLVYTMGTELFSSNSPTRLYGKACKLISDSPDVRKLMGDSSLTFYSQAPDSRRRRNHQIQHMTAFDAYGKEHMIMKFYVNSKLPSTEETQSWEEWIESLTITDIGKKVKRGIQTMINPDLRYDQPEKAQNEPTERSSWFGALGSGINRLGRHKKANASTLYDSGQAYADLVKNEAGYFEWNLLYVDVPHSRAFNRKRVYVHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ7</accession>
    <name>I4YBZ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958518.1">
        <property type="nucleotide sequence ID" value="XM_006958456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBZ7"/>
    <dbReference type="FunCoup" id="I4YBZ7">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBZ7"/>
    <dbReference type="GeneID" id="18473960"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60462"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="InParanoid" id="I4YBZ7"/>
    <dbReference type="OMA" id="RCNPEDI"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="183"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="655" mass="74462" checksum="7B5F5716C67CC68E" modified="2012-09-05" version="1">MHRVLFGQPRQALRSLRWYNRATVQQFSVQSALRQQASSKRWSHSSSNHSDYEYREKQSASSKSVYFLSKLPPSVILLLIFLPGTIILYNTNDTFKHTTLAGQRCARCAQAFVANVTDYKITLARNYANDDDKWDSLSRCHKRCAERVLAVLKSNGGVFIKLGQHISSVALLPLEWTGTMRPLQDQCNPSSIDDVNRILKVATGKSADELFASFEPNPIGVASLAQVHIAHDKSTGQKVAVKVQHPGLDEYAEIDIRTVQLISKGIKKLFPEFEFTWLADEMAVNLPLELDFRHESNNARRCKEDFAGKTKTSLYIPEFLWSHKLALCMEYIEGARPDDLNFLKEHNIDRNQVAKELASMFSEMVYINGFFHADPHPGNLLIRPAQEKSRSPYNFEVCLLDHGLYFDLSDDLRVNYARFWLSLMKPPSEATFKERRHYAKLVGNIDEDMYAIFESAITGKAGLEGAYEHELKGGPRKHKRSGGILDNTPAGNSSDVERLRSALVTKEGLITSVFGLLRSLPRRLLMVLKLNDLTRHLDTSLHTTHGSTRVFLIIGQYCEKSNHRATLQEISRRWTENGVSINLFWSYLKEYLRHFRSSITFSTLAGLQDLKSALVIWSTWSYALYARGFEGASKVAAGIEEQEKSKNTEEEKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC01</accession>
    <name>I4YC01_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_38467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958522.1">
        <property type="nucleotide sequence ID" value="XM_006958460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC01"/>
    <dbReference type="FunCoup" id="I4YC01">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC01"/>
    <dbReference type="GeneID" id="18472066"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38467"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650856_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC01"/>
    <dbReference type="OMA" id="HEEHNAH"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="394" mass="44561" checksum="39291C5B6BA36976" modified="2012-09-05" version="1">MLGGDLGEHFKNLHLNLLAGASIRLLLPGSSQFDSIPINSSNVDDTLESILQATPYYNNKEWRAFLNAYINLLNKVGDIWQLLTKCYTTVTPIYLSNSDNGVDITPTLKLLSTALVKYSFRISKEASSHAASLLSRLLAASNTDIPQRRRVLVHTANMLSWTYFKLRRLHSLPTALKAVIPIEDELKNNYPASEITTYRYWRARSKLAEWRVGAADHHFSIAYMSCHYNSIGNLRRIVSYWLTCALILCRAPTEDMLIRYGLEEPFGELFRQLRRGDVGGLYSALNQPNTRNFFIKMGVYTMLKEKLECVVHRSLLRKILTVRGDENRIIPLKIFLSALNFTAPDEEYDVDDAEAIAVSLIDQEFIGASIQHSSRTLVLAKANSAAFPIISQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCC5</accession>
    <name>I4YCC5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_64238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958312.1">
        <property type="nucleotide sequence ID" value="XM_006958250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCC5"/>
    <dbReference type="FunCoup" id="I4YCC5">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCC5"/>
    <dbReference type="GeneID" id="18474909"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64238"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCC5"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="263" mass="30394" checksum="5192076EA7727FBE" modified="2012-09-05" version="1">MAFWLVAAKEEFFEMRSEESHAIMKLNIANPQTGLQKTINIDDERRFRVFLEKRMSQEVPADSIGDEWKGYIFRITGGNDKQGFPMKQGVLLPHRVKLLLKAGHSCYRPRRTGERRRKSVRGCIVNTDIAVLSVAIVKQGEQDIPGLTDATLPKRLGPKRATKIRKFFNLSKEDDVRKFVIRREVQPKKEGAKPYTKAPKIQRLVTPQRLQRRRHLRSVARRNTEAQKEVVADYQKILAKRQAEKKEKLAEVRQQKAVKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCI8</accession>
    <name>I4YCI8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958367.1">
        <property type="nucleotide sequence ID" value="XM_006958305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCI8"/>
    <dbReference type="STRING" id="671144.I4YCI8"/>
    <dbReference type="GeneID" id="18475493"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68934"/>
    <dbReference type="eggNOG" id="ENOG502QWMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070892_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCI8"/>
    <dbReference type="OMA" id="YKGREWD"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="201"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="338" mass="38923" checksum="E95A72E1260850BD" modified="2012-09-05" version="1">MRKPYNIDDSFVDNFGRIHLDDKPLPRTPPAPPLPPRPSKSVYTSSKPNSAFDKPQISFPTPYYRGEPIKAPEQQISTPKAKARHSEGSLVIQSTKTPPHSPAKPNGFPTSPSEKPHSEQCHGITKQAKRCTRRVKSMNSETLPRFCHQHSKDILAQKGYYNTRGDWIAFEDWIPRHLSSYTQIQLRVLMEKPISATDAPGYIYVYTLSGSTTVTHVEYKIGRTNNINRRLDSWSKQCNRELVLRQHFPTSVAPSSRLLTTFAVDPKIQCVYVNRLERLIHLELSEYNDIEQQICKECGCKHKEIFRLRRMQTRQGTEFEGLIRPMIEKWNAYVARCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCR0</accession>
    <name>I4YCR0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_54349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958062.1">
        <property type="nucleotide sequence ID" value="XM_006958000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCR0"/>
    <dbReference type="STRING" id="671144.I4YCR0"/>
    <dbReference type="GeneID" id="18472663"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54349"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCR0"/>
    <dbReference type="OMA" id="ECTDHYD"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="139"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="454" mass="51892" checksum="62FACBCCFE258334" modified="2012-09-05" version="1" fragment="single">MQSPSYQSNQSIDYLSYQPPPQPASQVLVTDRSQLPTPPIPSRRPPHTRRRSDQVDTEPYSGYRPRLSIDYPSISKDQSIMRTSTSTPKLPPPTAQPLSPATNGGLQFNYPTQNTQEAVKNQQHLFKASYWHGDVTGLTGLKNLGNTCYMNSTLQCLSATIPFARFFTSGVWRRFVNHNNKMGMQGRLAESFSQILTHMWREQYTFISPMTFRKNICTFANQFIGTDQHDAQEFLSFLLDGLHEDLMVGEGQKPTEDTNNDALESLPTPLGSEREWKRYKQMNDSVIVDYFQGQFRNRMECMSCHKTSTTYNSFMYLSLPVPTKKLKGSVSLTTCLDSFLKDEVMEKDNAWNCPNCKVARKSIKRLSIARLPPILLIQLKRFSFNGPFSDKIETLVTYPLKNFNLTPYTPHMANQYYGITNKDDPTLQHPPFIYELYGVTNHYGSLQSGHYTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV4</accession>
    <name>I4YCV4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_64028</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958100.1">
        <property type="nucleotide sequence ID" value="XM_006958038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV4"/>
    <dbReference type="FunCoup" id="I4YCV4">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCV4"/>
    <dbReference type="GeneID" id="18474893"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64028"/>
    <dbReference type="eggNOG" id="KOG2794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCV4"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM21796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="327" mass="36318" checksum="9B58D90A397AAFEE" modified="2012-09-05" version="1">MEISSCLQGGYHKPLSRQWQNQGKSLQKSMFMYPIFITDDPDASVEIKSLPNQRRWGINRLQEFLAPLVEKGLKSVILFGVPLNMKKDYRGSAADDINTPVILAIKKLKQLFPELYIACDVCLCEYTDHGHCGLLREDGSIYSHESAQRVGEVALAYAQAGADCVAPSDMMDGRILQMKRKLIDNGFGNRVLVMAYSAKFSTNLYGPFREAAGSAPSFGDRKCYQLPPNARGLARRAVQRDLNEGADIVMVKPSLPYLDVISDTAQIASDYPVACYVVSGEFAMLHAGAKAGIYDLKSIAFETHESFLRAGANIFLSYFTPEFLDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCZ6</accession>
    <name>I4YCZ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958140.1">
        <property type="nucleotide sequence ID" value="XM_006958078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCZ6"/>
    <dbReference type="GeneID" id="18475464"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68756"/>
    <dbReference type="eggNOG" id="ENOG502RNQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476676_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCZ6"/>
    <dbReference type="OMA" id="IAGHIDY"/>
    <dbReference type="OrthoDB" id="10690769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="572" mass="66111" checksum="FE77CB09974B20AC" modified="2012-09-05" version="1">MSSDAQPSTSYQSTTVTNIKEEPEDVKPNIIRSPTPSIIDDFIPRYSGTDYEKWPQLTTQSTKDEITRNLKIKLRNQGKIILKTLKRSDGVAIDWRLQFQPHEVINIDQQNSQDDSIIDNSLTETQINHITNAIQLTQPTVEPTSEPITEHINQSESSKQLYQQPSHTGPSTPSTISLPKRPELPLHTKRAAKPIKVPTNPTPRASVRQVEEIRSSEKASQYDREKERRVQLRTENEQNRKLEERSQRSHDESLRINRQNRPHHGLQNDHDTTPKSFDNNRKEVYKMKQNDLEAQQREAEQKRQDEKHQKEIMERRNREIQQKKELERKEFEKKEREDREREALDFVKNDVNNNANRNSKSKNDYRSQKLKRTGDNIGFSGSEDHDQPYQEVAYGINLTELARIPKDSFSMVDKLSDIYGHIYELSNSGLEPTSQYFETISKLGVIKKQTKNALSQLLSNNNTNGSTTQSIDHNEESNTENSSKHKKKTDENKEKNEKVSTSALSSAPKQKKRKHNKEDQSISKKVANDAPEHLDINALNRGVNGTAQGYNEDNLEDCLRPVVDRRRKKNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD92</accession>
    <name>I4YD92_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958225.1">
        <property type="nucleotide sequence ID" value="XM_006958163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD92"/>
    <dbReference type="GeneID" id="18473877"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60307"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_4_0_1"/>
    <dbReference type="InParanoid" id="I4YD92"/>
    <dbReference type="OMA" id="SINIMII"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="248"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="621" mass="71377" checksum="46FCC9C93131AD97" modified="2012-09-05" version="1">MYEVSYVENMKEELSRCQALLDESASTSKDSLERKNNTDIIPSSDYEDISDEHLVDNLDGLYTHTHEERANIKFFGNSPFRGLFARIEAYTGLKTLDFINGKRPQYWLDDWSRAISPHSYFTSLPYTNEDFGDEALLEQLITLYFEKVNVSMPLLNESHFRKQIPNKLNRSFGTILMLVAALGALYLDDNRLSIPGRENLKFLQGYYYYNIAVEKMPNYMKASAELEDIQALILLQMYVQRGVHTKSSSMINGLTILLSQNIGLHSKLMNENHDDIIEKEARKRAWWILYIMDRSNTACFGRNLLIKDDEMHLDHLQVTAEDPSNNTDSIKYINDIIKICEIHGQITHKLYKFSESNPGEDAILEMKDIAMLNTKINDWINDVSITEEDIKNDTTYQLRANIKLAFYNAQLILYRPFMPCPTLKRISNFQTASLAICSNASRSIISIYSDLVLNRKVDRIWADCLISWCPFWATLIMILSFCESKRIGNIRYQDLDYIKTGILTLRSVESENVLYGRAVDILLSIVKTLLPPGDAFIEDQQLISLDTEFYSTVAAHTLQPPQDNVNVVEQDNIFFRDMLDYLRSDSSNSVHGSYNLLISPEHENDLNMMINSILDGDADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB3</accession>
    <name>I4YDB3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_63704</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957767.1">
        <property type="nucleotide sequence ID" value="XM_006957705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB3"/>
    <dbReference type="FunCoup" id="I4YDB3">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDB3"/>
    <dbReference type="GeneID" id="18474861"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63704"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_0_3_1"/>
    <dbReference type="InParanoid" id="I4YDB3"/>
    <dbReference type="OMA" id="RFKTPRD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="112" mass="12426" checksum="1CDC73374B81F1C0" modified="2012-09-05" version="1">MLKSQFSLISRAAKQTQAFKLPSRFYASQGLSKNDIQQRIFDVLKSFDKVKADNLTESASFTNDLGLDSLDAVEVVMAIEEEFAIEIPDAEADAIQNVNQAIDYIAKTPEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ0</accession>
    <name>I4YDQ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957895.1">
        <property type="nucleotide sequence ID" value="XM_006957833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ0"/>
    <dbReference type="STRING" id="671144.I4YDQ0"/>
    <dbReference type="GeneID" id="18473784"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60165"/>
    <dbReference type="eggNOG" id="ENOG502RY79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1273132_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDQ0"/>
    <dbReference type="OMA" id="WAYIATI"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26013" checksum="7BC8AC958614F0B9" modified="2012-09-05" version="1">MTKLTMKQIKNRQSIHPGSRKAEQVTRVNLRLNKLDKQRKVMDTEKTNKMSRYNFIASQLASIEPEPELLSLEDLHNLVELYINRDDDHYNELRATREQRDKSLQRSSGKSARESELESRKERDLQEYASGFIVPDLSDSLTMKLFKQFPCARKLSKKSKGKTQASAIGGISNNKSDANSLTPEELAEYGLDYNYLPQLNLVRIYKNDRNLKDLSQKGKNNLYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ8</accession>
    <name>I4YDQ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">VHS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_28343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957902.1">
        <property type="nucleotide sequence ID" value="XM_006957840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ8"/>
    <dbReference type="FunCoup" id="I4YDQ8">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDQ8"/>
    <dbReference type="GeneID" id="18471034"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28343"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333759_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDQ8"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="8">
        <location>
            <begin position="183"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="9">
        <location>
            <begin position="392"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="10">
        <location>
            <begin position="554"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="799"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="817"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="856" mass="97051" checksum="3CA9BDD926DAF6BF" modified="2012-09-05" version="1">MKFTEKPEQLSRLPTLAEVLSRKTRPPVDLFCLYLFLQREGSEDALDFWLDTQQHENLCRAYFKDISKSGRSLQDVWPEYLSSARLAVSPDNSEQDRLTPSPIANSQSKSVNSMNSSSGTQENPIPLDNFLRDTSNRQNLSTSDFEPDRPSTRLSTKRKSAQRAPTTIPRNAVISHADLFDSAERIYYRYLAPGSDKEIYLPPALRIDSFGHQTPLTDIPDLFYPQKEYIFRALEGGVFPRFLRAKGFGNLTPMSSLIRLGLGLFLLWFAFSLGFCFIFLDHKPQKTRVWVLLPFIISLFLLWSFQYNLDPLLVLFNKSETTPFRTINIEESYIKKLLVMRSVYGVDYTINRNTNYNIYATMLNPNTLGRLGSPWGRNPRTSDVLSSYINMACEPTLLEPNQSLEMEIADYINTKKSNCPREAAFEILRHVNQGSPRSALLGLHLLDVLVKNCGYPFHLQIATKDFLNELVRRFPERPPAYPGPIMGRTLELINEWKNGIATTSKHKEDLVHIRDMWRLLGYKGYRFPELSRNAAISVATDNLKSPEELEEEDREAQSAKLQELIRRGTPRDLAAAQDLMKKLSGFDERKPDYRAQTIKELEKVQHKAILLNDMLDQAAHTQEKLVRGDAYDQVSSLCKQASPKLQKWISEASESESDLLERLLQINDLINNVLNRYNAFKNGDYNATFEMNENFQSKGMTSRSSNRNDAGQNLIDFDDPLQHEHIERENEQDSGVQLTQNATDLPIDLFSAPSPGPSTTAEAQVPAMQSPTPANNLSSNEALKSLYAMGPSINTPVSYSQPFTPSAQTPITPGVSTPNVINTTTPPVQQSASQQPQQSQQPQQKSPFEDLVDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDS8</accession>
    <name>I4YDS8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957922.1">
        <property type="nucleotide sequence ID" value="XM_006957860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDS8"/>
    <dbReference type="GeneID" id="18475433"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68592"/>
    <dbReference type="HOGENOM" id="CLU_395481_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDS8"/>
    <dbReference type="OMA" id="IREWKEP"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="76920" checksum="192EDD5B76374400" modified="2012-09-05" version="1">MGPYECSNCKYKFNFIDNLERHVARNRCGSSYDPSINLLNITEVNLEVIDPPFKNMKVPTPEPRLRALPPRTTRVTRGNATQVEKQQIVDEVSNGRDKVFQCDCGKQYGYRESIYNHKKHGKCTGKPWGAAIIKCIPANPTVDDRKDAYKKRKVTDEEEADSKSTSSSPAPVIQPTSRQQRAAAAQATKTLSQEPQTGRTNLPTLPPLSSLEDHKPDVSMFVQNPMTVHPQPATIQYPNQPLYNSMAPPNIPGISSSASTPTSEVPPSIKKPITRIRQPEHEKAFACDCGKRFAYKTSIYHHKNRGGCPGRPWVTSEGGHRNRAKTGKHLSMMRAHELAQKMGEVGTLNVDFDNVPDHLKAEVANPIIVSKTKRKKSSISNGSESSSNAAGTSQDGSAGPSETPQPRPTIGLKIKEWKEPHPRQIGRPSLARQQLEQEIHQGNKHLISVHSPMVSSPTNQIPRPSNYSPSPHESSAPPIMHTTSQTNAPTAISTTPSNGQYNPLSMSRQNTQLVMQHEGNQTMQRHQHQHAPVTSQPLVNNNHPFAQQNSQLMTPSNSNNPESTTPSHASLEFDDSIDSEAYAFGDIDDEGCISRTRWGPAGQALAENLAKRHELRKPASPTPFRPFVCLVPGCGRSYKNSNGLAAHFSSIRESGHGELGRKLRDEAKEKDHNPGFVGVFDSIMMDHPIPDEPEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ5</accession>
    <name>I4YDZ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957982.1">
        <property type="nucleotide sequence ID" value="XM_006957920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ5"/>
    <dbReference type="STRING" id="671144.I4YDZ5"/>
    <dbReference type="GeneID" id="18472890"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57226"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDZ5"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="200" mass="22772" checksum="3873422BA06480C9" modified="2012-09-05" version="1">MSYFDKVKEQKGQLFNNVTITEKGVNTTEFLDAAAVVVQLFDILGNKAFSVVQNDLLGNIKKVRDRHDAEPLRSGTLEELVAAENLDKKTTATQGLVWLLRGLEFTYKALLRSLRNPTEELSESFSKAYEDSLKKFHSFVVKPIFNLAMKACPYRKDFYEKLGGDPTTVEIELGDWLSALEKQVLQVQDFMKQHNYDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE79</accession>
    <name>I4YE79_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957534.1">
        <property type="nucleotide sequence ID" value="XM_006957472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE79"/>
    <dbReference type="STRING" id="671144.I4YE79"/>
    <dbReference type="GeneID" id="18473667"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59987"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE79"/>
    <dbReference type="OMA" id="SMKQCIE"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="12">
        <location>
            <begin position="205"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="541" mass="62079" checksum="602AB2B67DBEB6D4" modified="2012-09-05" version="1">MEIALKSFDERRRELINKEKEHRLDSNEQRILFTIGGKYAIAAATINDIRTREWDTIWSASQSREVGAPFLTSKDIIKSSKLYEIIQRMPKGGLLHAHTDATLPLNDVFDIVHKYGANIEICSTHPLTAENLDNGHAKLQFRPTKVPITEASTEIAASMLTNDYKPGMWCNYHQISTLFKDSKLDDYIHAQMLISAKECYVTHNTMGKIWSKFSNCFSVLAGLLSYEPIWEEYAKRLVLNCVDDGVGYLETRLLMITEFFYDIECNLRLTRRDTVLILLRGIEAAKRTLQEQGKVEQFYGLKVIYCTLRFLKPEEIWSSMMICLDLYKEFPELIKGFDLVGHEDSSEAYTLKAYLPILLRFQELQLEEFGDIKVPFVFHAGETLGDGSPVDENLYDALLLGTRRIGHGYSLYKHPELMKMCKERGVLVESCPISNEVLRLTGGIGNHPVAALINHGVPVSLSSDDPAIFQNPILSYDFYTLLNHSTKTNLATLKVLARNSLTYSLMENPMKERVMRKWEQHWDEYLDWIVNIMGSKKELYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE89</accession>
    <name>I4YE89_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_31992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957542.1">
        <property type="nucleotide sequence ID" value="XM_006957480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE89"/>
    <dbReference type="FunCoup" id="I4YE89">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE89"/>
    <dbReference type="GeneID" id="18471404"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31992"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="InParanoid" id="I4YE89"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="229" mass="25208" checksum="3236C055C5ACA5B2" modified="2012-09-05" version="1">MSSEERKYNALSKEPYPDNVKTSFDSVKDAVEAYKNGEFVIVMDDEGRENEGDLVIPACGITAEQMAWMIKWTSGYICISLEEERLRELDIPMMTGENTEKHRTAYTVTVDYLRGVTTGISAADRALTARMLSPSSGAVASDFNRPGHMVPLRYHAGGTTQREGHTESATDLAILAGLPPAGLLCEIVNPDAPDGSMARLDDCFKFAGRWDIPIITVKMIKQAIENRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEA1</accession>
    <name>I4YEA1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_44679</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957550.1">
        <property type="nucleotide sequence ID" value="XM_006957488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEA1"/>
    <dbReference type="GeneID" id="18472340"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44679"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017408_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEA1"/>
    <dbReference type="OMA" id="WVYILAT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="269"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="570" mass="61971" checksum="35CAAC5423FAE3B5" modified="2012-09-05" version="1">MKLPEEHSIYLQAFFGGMIVVAFLARLPAMINWVIAGGIQRATFLHKGEIDGPGAYPYSIVAKSPFPNSQKSKPNIFERSINQITPTAHTPLPGLSLTAGQAFVFALATAASIFVFAYGPTNPIENPGRAGWAAVAVTPAVTALAFKNSIVGTMGGWGYEKLNKLHRLLGRLSVLFGLLHTAGYAHIFSQHNTVASSLAKPMNQAGIFAIIGMLLTAVFSIPWCRTHFYNVFWHCHWIGYWMYLIAIMIHWKSTQPFIIPCIVAYGIDCAMRFARSRSRLAEITPHPAAGYTTITIPDLRGGWEAGQHVYVRVQELGGKFFGLGNLIEKHPISIASAIGGSDGLRLIIRSNGDWSSRVLALAQRKQNEITYGSEKGNDSVPTAAVSVEGPYGGPFYTSFGKSGHVLFLAAGSGLAFVLSCAEDLVKQSRGGHCRATTCQVIWIVRDVATYQVFHEELMTLLVAGSLVPLDLTVKVYITRHVNSAGVSSDDLNYLLPHRDGEIIAKRPSIAAIIEDTVFMAKDRNCTYGLMVGICGPPSTVRSCRAAIGGVDPRYLKEIGGVREHCETFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED2</accession>
    <name>I4YED2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_32031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957579.1">
        <property type="nucleotide sequence ID" value="XM_006957517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED2"/>
    <dbReference type="STRING" id="671144.I4YED2"/>
    <dbReference type="GeneID" id="18471410"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32031"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="InParanoid" id="I4YED2"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="746" mass="81445" checksum="3F8A5C0C57FE5C9E" modified="2012-09-05" version="1">MLRSAITRSQLSRVAKSSHRSLSSSAFRNAETAPMIKLTVDGKEVEVPQGTALIQACELAGATIPRFCYHDRLAIAGNCRMCLVEVERAPKPVASCAMPAMPGSNVFTNSERTNKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGSDRSRFFEVTGKRAVENKDFGPLVKTSMNRCIQCTRCVRFANEVAGVEELGTTGRGNDLEIGTYVQKTLDSELSGNIVDLCPVGALTSKPYAFTARPWELKTTETVDALDAVGSNIRVDSRGHEVMRVQPRVNDDVNEEWISDRTRYACDGLKYQRLTNPLIRVGDRFQAASWPDALATVADSLKKSGAKGDEIQAIAGSLADTESLVALKDLLNKLGSENTALETKRGNAPPVHGVDHRSNYLFNVTIPGSEDADAVLFIGTNPRHEAAVINSRFRKSYLHNGTDFGVIGDKFDAIYDYEHIGVDAKTVGDFLSGGVKSPFAEKFKNAKKPLIVVGSAVAEHQDAESVYAAIAKHVETNKERFLTEEWNGFSTLQRAASRTAAYDVGFVPSHQAQSTKAKFIYLLNADDFDPDVIPRDAFVVYQGHHGDVGAQYADVVLPGVAYTEKGTTWINTEGRAQLGRAAISAPGASREDWKVIKALSELIGKPLPYEDIVAIRDRLWEISPALTRYDELEAPSSVSVGLGLAELVKNGQATTSTTPFQKPFENFYQTDPVSRASVTMANCVKSFVKGQNSEETSIPVGKDEQQKQSKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEE1</accession>
    <name>I4YEE1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957588.1">
        <property type="nucleotide sequence ID" value="XM_006957526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEE1"/>
    <dbReference type="FunCoup" id="I4YEE1">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEE1"/>
    <dbReference type="GeneID" id="18473687"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60018"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="InParanoid" id="I4YEE1"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="15109" checksum="14EA113970B1386A" modified="2012-09-05" version="1">MSDAEAREAFALFDKRGTGKIPSGQLGDLLRALGQNPTQAEVESLRSSAPSELDYKTFLTILQRPDGFKPAGELEDFVRGFQVFDKDGSGVIGAGELRYVLTNLGEKMSDAEVDELLKGVPISSDGNINYRDFAAHILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF9</accession>
    <name>I4YEF9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957606.1">
        <property type="nucleotide sequence ID" value="XM_006957544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF9"/>
    <dbReference type="GeneID" id="18473696"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60031"/>
    <dbReference type="HOGENOM" id="CLU_2672987_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEF9"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="75" mass="8672" checksum="8800A9458FAA7604" modified="2012-09-05" version="1">MELIFYAVHKGRQTGIYPGLEKALYQVKDYPGARWYAFHSYDKARHFVRSGNITTYYDEDYALKAETEGVVMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH3</accession>
    <name>I4YEH3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_63568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957619.1">
        <property type="nucleotide sequence ID" value="XM_006957557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH3"/>
    <dbReference type="STRING" id="671144.I4YEH3"/>
    <dbReference type="GeneID" id="18474850"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63568"/>
    <dbReference type="eggNOG" id="ENOG502S5QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEH3"/>
    <dbReference type="OMA" id="ICAHAAP"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="249" mass="28211" checksum="6C3FECC282AC20D6" modified="2012-09-05" version="1">MIDKILICRHGFRANWVAGSSWPTEDRDVPLAAHGVDQSRHLAEHLKKEFVPSSIYSSPFKRCLQTAQPTAQAFKLPIKVEPGEWFHENPPNKAPTLHPQPYESDLKGAFVEVDARYQPTYFPNRHGESLEQLHERCKIAIDNLILREEKKGVSGTIIIFTHAASAIALGRALIKDSTRGIRTGCTSYSEYSRLGNVWELKNNGYSQHLPQGEERHWDFSLSTREYEDGMEGTENIGQGFWGLVPEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEM3</accession>
    <name>I4YEM3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmentally regulated GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957661.1">
        <property type="nucleotide sequence ID" value="XM_006957599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEM3"/>
    <dbReference type="FunCoup" id="I4YEM3">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEM3"/>
    <dbReference type="GeneID" id="18473715"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60062"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEM3"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="365" mass="41064" checksum="9D926DADCA65869A" modified="2012-09-05" version="1">MGVLEKIQEIEDEMKRTQKNKATEYHLGQLKAKLAKYRQQLLEPTTKSSKPGEGFDVMKSGDARIVMIGFPSVGKSTLLSKTTKTESATAAYEFTTLTAIPGVLEYEGTRIQLLDLPGIVEGASAGRGRGRQVVSVAKTADLVLMVLDATKSLEQRTLLEYELEAVGIRLNKKKPDVQIKRKKTGGVTINCPVELTKTDQRTLRSILQEYKIHNADVMIREDITADDFIDVVLGNRKYMNCLYAYNKIDGVSLEEVNRLAHQDHTVPISCEMDLNLDYLIERMWEQLDLLKVYTKRRGTHPDLDEPVCLRKGATIEHVCHSIHRSLAESFKYAIVWGKSSKFSPQPQKVSFSHRIANEDVVTIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEM9</accession>
    <name>I4YEM9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_32124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957666.1">
        <property type="nucleotide sequence ID" value="XM_006957604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEM9"/>
    <dbReference type="FunCoup" id="I4YEM9">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEM9"/>
    <dbReference type="GeneID" id="18471424"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32124"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="I4YEM9"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="603"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="689" mass="76773" checksum="EDC64D1A64ECE304" modified="2012-09-05" version="1">MDSQIIGIVNKLQDAFTNVGIPNPIDLPQITVIGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRPATSKKDDNEQRTNENNPDEWGEFLHLPGEKFHDFDKIRDEIVRDTELKTGKNAGISPLPINLRIFSPNVLTLTLVDLPGMTRVPVGDQPRDIERQIRDMLYKFVSKPNAVILAVTAANTDLANSDGLKLAREVDPEGTRTIGVLSKVDLMDAGTDVVDILAGRVIPLRLGYVPVVNRGQRDIEQKRAISSALETEKSFFENHNSYRSKAQYCGTPFLTRKLNMILMHHIKSCLPDIKAKISASLAKFQAELQSLGGAHGEGNGANVVLTVITDFCNEFRTVIDGNTHDLSLQELSGGARISFCYHELFNNGVKSIDPFDQVKDGDIRTILYNSSGSTPALFVGTTAFEIIVKQQIRRLEEPAIKCCALIYEELIRILSQLLGKIQSFKRYPALKERFNSVVIASFKKAMEPTQKLVTDMVNMQACYINTTHPDFLSGHKAMALVTERQQQAQKAPPPAVDPKTGKLAPGVLNNNRDLDVDTKKEEPSFFGSFFSKTGAGAQKKKSGPIMESPPPQIRPQSALNDREALETEVIKMLITSYFNIVKREMIDMVPKAITYTLVQKSKDQLQRELLQELYKNEVLDDLMKESDFVVQRRKECIKMVEALNKAEEIISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YER7</accession>
    <name>I4YER7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957700.1">
        <property type="nucleotide sequence ID" value="XM_006957638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YER7"/>
    <dbReference type="STRING" id="671144.I4YER7"/>
    <dbReference type="GeneID" id="18471428"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32146"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="InParanoid" id="I4YER7"/>
    <dbReference type="OMA" id="HKTDATN"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="278"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="553" mass="61142" checksum="51D7FBC7059287FF" modified="2012-09-05" version="1">MSREEPKLDSDGPPEFVAAIDTGTFRSTRCILFDKYGTPTLMHQVEYPQHYPYPGWHEQDPLDLLESVYIVMDCIADKMEAAGIPFDAVKAFGITNQRETTLVWDRKTGQPLYNAIVWDDSRTNTMIKELSGEEGPDILKDKTGMPLTTYFSGLKLKWLVENVDDVKIAMEEDRLCFGTIDSWYLYNLTGGPGKGLHYIDISNASRTLLFNLRTCDWDNSLLDFFGLKSSILPEIRSSSEVYGKIDHGPFVDTPISGMLGDQQAALVGQKCLRAGEAKNTYGTGAFLLFNTGEEVKYSKNGLISTVAYKAGPDCPTHFALEGSVSVAGAAITWLRDNMALIDSASEIGELAAQVHDTGGVYFVTAFGGLFAPYWDSTATGTLIGMTGYTTKAHVARATLEAACFQTRAILEAMNADSGVNIHILRVDGGMTNSDLAMQIQSDILGVEVERPTMRESTALGSAIMAGSALNLWGWDVTKPETLEKVNTAGNVFFAPHDDTKLRTRVYRLWNRAVERASKWNTIDFVQEEVEAELEEKLKIEKGDDNEKKNESRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YER8</accession>
    <name>I4YER8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sum1</name>
        <name evidence="7" type="synonym">TIF34</name>
        <name evidence="9" type="ORF">WALSEDRAFT_44919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957701.1">
        <property type="nucleotide sequence ID" value="XM_006957639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YER8"/>
    <dbReference type="FunCoup" id="I4YER8">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YER8"/>
    <dbReference type="GeneID" id="18472348"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44919"/>
    <dbReference type="eggNOG" id="KOG0643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="InParanoid" id="I4YER8"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="334" mass="37463" checksum="0662C7301E210670" modified="2012-09-05" version="1">MRPILLQGHERSLTQIIYNKDGDLIFSVSKDHRINVWYSHNGERLGTYEGHNGTVWSVSVDKNSEYLVSGSADNTLKLWSVKTGECLYTWEFPTAIKRVQWSNDDNRILAITEERMGYKGALRIIEINKQQPTQQSAEPKHFFEPAGSKITVAAFTAIGNEVVTGHENGKIAKYNYEEQKEVAASEGAHQDSIMDLQLSLDQTYFITSSKDKVSKLFDTNTLETIKTFSTDSPLNSASIAPGSPYIIVGGGQEAMNVTTTSARQGKFECRFWHKVFGEEVGRVKGHFGPINTIAVHPEGKAFASGGEDGYVRVHWFDESYFRTRVYGDLEPEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEU5</accession>
    <name>I4YEU5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957727.1">
        <property type="nucleotide sequence ID" value="XM_006957665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEU5"/>
    <dbReference type="STRING" id="671144.I4YEU5"/>
    <dbReference type="GeneID" id="18473737"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60093"/>
    <dbReference type="eggNOG" id="KOG0463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012821_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEU5"/>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="176"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="595" mass="65071" checksum="C3A66625138A5F0D" modified="2012-09-05" version="1">MAQLTEFRREIDSIHEKAIRAQREAGHAKYLETALSHSKQQAKAAKSLAHKPLEAEIDKLSLDKDISGNLVNVNATNVVELLLSNDPPIDSIGLYVEDCIRSARGEYVASLGNATDGFQSDILTFEQVLVILKQLKKACKSVDCGLGVLYQRVTEDEKEAFVKIIIRRLPTSAELFQEVRLAVCGNVDAGKSTLLGILSRGGLDDGRGKMRVNLFRHKHEIESGRTSSVGLEIMGFDHEGNEVQSATQKHGWDEICSRSSKIVSFIDLAGHERYLKTTIFGMTGTQPDYATLIVGANAGLIGMSKEHLAISLALDVPVFICVTKIDMAPPNVLEQTLKQLTKILKSPGCRKTPVFIRSKEEAAELSSTFVRDRVAPIFLISSVTGSGIPHLKTFLNVIPPASAGPDLIEKPLEFMINDVYSVPYAGTVVSGIVNTGSIRLNDTVMVGPDSLGNFITTSVKSMQRKRSNVNIAEAGQSVSLALKRVRRTAVRKGQVVIAKTEPPPKASWRFVGNILILYHSTTIKPSYQAMAHIGSIRQTVKVVGLNNDNNLLRTGDRASVTFEFVKNPEYIKEGMQLLFREGRTKGLGVIAQVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFR5</accession>
    <name>I4YFR5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YabJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956861.1">
        <property type="nucleotide sequence ID" value="XM_006956799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFR5"/>
    <dbReference type="STRING" id="671144.I4YFR5"/>
    <dbReference type="GeneID" id="18472817"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56517"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="InParanoid" id="I4YFR5"/>
    <dbReference type="OMA" id="VKLNIFM"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="14465" checksum="BC1979D9D1016BEF" modified="2012-09-05" version="1">MSIQAFSNKQYIPASAPLVQTIKYNGLVFISGCIPLTKQGKIIEGDISLHGKVALEWMKDALAQAGTTPSRVLKVTCFFGCNLEQVPQFNEVYGNFFNEYNHKPCRTGVKVAGLPSIDGVQALVEIECVAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG17</accession>
    <name>I4YG17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_36157</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956955.1">
        <property type="nucleotide sequence ID" value="XM_006956893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG17"/>
    <dbReference type="FunCoup" id="I4YG17">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG17"/>
    <dbReference type="GeneID" id="18471947"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36157"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007736_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG17"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="16">
        <location>
            <begin position="173"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="14">
        <location>
            <begin position="368"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="537"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="895"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM22909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="962" mass="110898" checksum="57EECF53DAA460B3" modified="2012-09-05" version="1">MTIDELKDIFPLTKPLPTPSNNKSIAKVIDLQFEEELSRNPTNLRTWFSYIDVIQSKLDILTPIDDDDNLDIVLKEILGPLATEDRRSIYQTLTSIYERALAMFPLNYRLWFNYLLMRLSFLTGNITAADISQLKNTRRRLVKGQPIVDLEKGDERIPWKEVSESNYLDGIVGESEWKATAAVFERCLSWMPSMPRLWILYLSLLSNPACPSRLAHTHARRTFDRALRTLPPSLHVRIWPSYLNWAKSIGGNCLTIVWRRYLAVDPYPIETYIQLLLNGEQASSRALEACKLLLKLSRLSRENHYVSPQGKSPYMLLNDWLEVCSEYADVIGVDVDQATALKPLQVGGKQNEMDRTEGTSSDQLVKSTIDSSADADIDPSSSQKLDVDSLVRQDGLSIYKDQAGRLWTGLATYWIRRGEFDKGREVFETAIDSVVTVRDFTQVFDAYAEFNEQLVTSLMDALADIEDEEKDDLEKELDDNMQSFEGLMDRRPFLVNDVMLRRNPNDVNEWQKRVALFDNNDEKIVETYTQAISTIKPKQAVGFGDLYANFAKYYESKGDLDSSRQIFEKASAVHYRRIDELAEIWIQWSEMELRHDNFEEAISVMQRATVIPKNTKVDYYDESIAPQRRLFKSLKLWSFYVDIEESIGTTESTKKVYDKIMDLKIANAQVIINYALFLEENDYFDDSFKVYERGVDAFTYPVAFELWNVYLSKFLKRYGGSKIELARDLFEQAIEGMPSKFAKPIYLMYGKLEEEYGLAKRAIRVYERATQAVSDKDKFEMYKILIAKVAMNFGMAATRPVYEKSLEELPDKAAIVMGLRFANLERKLGEVDRARSIYAHTSQYCDPRIHKDFWEEWNQFEIDHGSEDTFREFLRIRRSVQASFNTEAHYLAAQSLHTNKDKEGEDEEAANADPMANVERAIPGFVKGQTQAKVGADDGNEHENAEEATNNQDEIEIDEEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG26</accession>
    <name>I4YG26_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956964.1">
        <property type="nucleotide sequence ID" value="XM_006956902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG26"/>
    <dbReference type="STRING" id="671144.I4YG26"/>
    <dbReference type="GeneID" id="18473496"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59682"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696770_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG26"/>
    <dbReference type="OMA" id="DEMAWGV"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="396" mass="44080" checksum="7E889AAB6EA22D7B" modified="2012-09-05" version="1">MANELPVSPALEFLTGFSSKSSQSNLLDEGDNVDEFVIGTVLSSGSSALVRYAKHLPSSTAVAVRIVHQSDSSDLSNEVTKWSQFNHQNILPLLHHSTYSSFLLTFSPICTGSLLDHVKKYFSNGMSVNKAHSIFSQIAQGVSYLHDECSVVHRDLKLENVLLDNAGNWVISDFGLSQSKADTLSQPIDTGSLPYASPELIRPPDQTLDTEKRFDLLKKADIWALGCILYALLSGKLPFSDAFVPRLRMKILGGSYQRLTSASRSRERSITRSRSRSRLRATDEADELAAISVLEMCLDPDTSLRPLIQQLLENAWVSGVQHHHSFVETARPRMQSRSTSRNRSSRSRSQSRARGMPQAMHHLSPVEEKTNSSNEEEERGRPTIKRSLTRDTNVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG97</accession>
    <name>I4YG97_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_31642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957029.1">
        <property type="nucleotide sequence ID" value="XM_006956967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG97"/>
    <dbReference type="STRING" id="671144.I4YG97"/>
    <dbReference type="GeneID" id="18471345"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31642"/>
    <dbReference type="eggNOG" id="ENOG502SCD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023792_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG97"/>
    <dbReference type="OMA" id="MISDDAH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29062" checksum="E3E1A398AC251724" modified="2012-09-05" version="1">MRNANDALNSLSARLKGEVDSITAQIEAGNEFEIYIKALSLLTDIEHLRKNIGLEFEGYDNFRGFVDSTEKKASSDLVYPTLPPTIDAVLDNKETLSEEPEFVPRELTDTVNEVSLEKPTTSQPVQPSEPVKKPQPSYTYDYHKEKELYESRRKGKDTNGAVSQRSARAEQDDLSEELIAMTKQLKQNALALSQGLSSDMPLIEQTSNKLEGNADKMTTQRKQLNIFSSSSRATTCLTFSSIVIVFISWIILFMIIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGA2</accession>
    <name>I4YGA2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_31647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957033.1">
        <property type="nucleotide sequence ID" value="XM_006956971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGA2"/>
    <dbReference type="FunCoup" id="I4YGA2">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGA2"/>
    <dbReference type="GeneID" id="18471346"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31647"/>
    <dbReference type="eggNOG" id="KOG1952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005714_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGA2"/>
    <dbReference type="OMA" id="CPHPCDS"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="843"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="96942" checksum="D70EA5A4487B02D8" modified="2012-09-05" version="1">MEIPGNRADNKPSTSSRGRGRGRGRGHGARGGRKSHSTRQSISETNEESSTQPSSEPSNSDRPKPKPRRKFNGSLTQSGQQSQPLPPIPQVETTDEDDIRSRLERELRVGKVECLICFEVVKTQDRTHSCNTCFNVYHLKCITEWAKQSFGQPFKEGEQKHWRCPGCQTKSTKIPREYRCFCRRQRDPKPDKLAVPHSCGQSCSRKRQHCKHPCPLPCHPGPCMDCQTSLHVKCHCGKTTTPIKCAYAPRDPSTGKILPTACGDVCGKQLGCGQHSCIDQCHPGPCSPCNKVENSKCYCGKERSEKPCGTRGYLGKQACYSKDEFYIALWECSNVCGEYYDCNFHKCQGFCHPPSRKALTCPLSPEVITRCPCGKHALKELNNGERKSCQDPIASCGKTCGKSHLNCGHICKSKCHTDECPPCDAEITTVCRCGVSKVTRKCFEVQQEGEEVLCDRVCHSLRLCGKHECLKRCCPLREFEDRRGKRKALIDTQIPEEVMQMWHTCPIICGKTLSCGTHKCLEPDHKGKCGPCLNASFDELTCSCGNTTLEPPIPCGTEIHCTYPCNRPPPECGHPRPSHTCHGDDVSCPPCPFLTTRSCQCGKSQISNVRCSQENVRCGKKCDKIQECGHRCKKSCHKDECRGPEEACSSVCGKLRSICSHTDIAQCHGLTPCDESMPCQAVIIMACKCGTQKAKATCGASLSNTHSKQDVYLECKSSCAAAERNSRLARALGINDTFKRKIDYNFSSETIRFAQINQGFVSGIEKAYNEFIDSSNRALQLPLMNKSRSAFCIDYAEAYGFDTEIFEDVITIRRKIGSHLPSQLLTKLVDEYKQDKAGVIEFRKPSGQSTPQLSRQGSVSTHQSDDWEELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB0</accession>
    <name>I4YGB0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_63023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957041.1">
        <property type="nucleotide sequence ID" value="XM_006956979.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YGB0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGB0"/>
    <dbReference type="GeneID" id="18474805"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63023"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_2_2_1"/>
    <dbReference type="InParanoid" id="I4YGB0"/>
    <dbReference type="OMA" id="FAHVNDI"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="284"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="598"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="912"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1383"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="931"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1424" mass="160132" checksum="2F2D4543D7DA111D" modified="2012-09-05" version="1">MSKERRSDAFQNIFGRPSASHHQQGYMPHQRYYQQAAQQQQQQQYYQQYYYQQYGYDYDQYYRSQSAMGYNQQQPYYNPSAYNYGNDEQLPTSGSTNSQYSSSSAYALPQSSSSQSYLGNYQGIPRVPTAPPDRLMEVEEETQALPPPAYSQATHENYVPRVSQTPTPVAYNRPSQTPLSIPQSYNYSQQRSVSGGPATTIATQAPPSVITEPTRSDTLNTPSVTPAQRANSFPSAAQTGASPTFPKITARSGSKNRREAIIAPRRSALNKIYPALLSRVAEAFKSQLPLSEKVKDDLTYTEAFDGSQAVDLLCQIIRTTDRNIALLLGRSLDAQKFFHDVHWEHRLRDSDKEIYRFKERIPSPIFADGENAPVDIDDDDDLDDSESPKGSNNLAPAKVAIPSRSASMPSRFKNKKSSVDRKDKLATSNKQPRSSAPIDFTYNEADGSEVKDSSSSTSINELPTGVFTLLTACYSPTCTKDRLCYSITCPRRIEQQHRMANRGTIKNSEGSLKRSTTKKVAKNVLTRESIGEEPVIEETITEGLNELNVGVGEEASDGVVKAELGSSSNIASDRASGQLWVESVPKEVVESCSSDEIKRQEAINEVIYTEQDFVRDLEYLRDFWMEPLSSGNIIPEDRRMAFLQQVFWNVLEIHASNVQLRDALARRQKSKLIVDRIGDVLLPFAQSFGPFVNYGSHQLYGKYEFEKEKSSNAEFAKFVTEVERKKESRKLELNGYLTKPTTRLARYPLLLDVVLKYTPDDHPDKKDIPIVVDSIRAFLRRVNVETGKSENRFNLAQLDSQLQYKPGQERTDLRLTDESRELVFKGALKKRGGAPPSESAELQLFLFDHAILLVKPKIVHKHEVFKVQRKPIPLEMLVVTSNDEQFNSRQNSYSVPASSGHKPRTLLKSQSHAKMNDLTHSERDSTHSLHDTISTDTLSTTAPPKPESRLGYSMTLHHLGRRGYSVTLWASTFMNRRKWLEHIHNRQKALKETKAPFELDIISDGFFIGTDKANCAVPYSQGRKLVYGTDNGIYMSDKPNEPPRKVIGMPSVTQIEVLEEDEIIVLLAERSIWTFELSVLNENDPEGSLKMGRKISSHTSFFKSGKCLGRTLVCIVKSSSLSSTIKVLEPIEKDLRNSKKPPTLKKLVGGGKEVLRVFKEFYIPTESSSIHFLRSKLCVGCTKGFEIVDLETLDTQGLLDPADTSLDFVVKREGVKPMAIYRVEGDFLLCYDDLAFYVNKNGWRVRKDWLIRWEGQPRGFAFYYPYILAFDPNFIEVRHISNGELVQVIAGHGISLMYADSSNSTPLSVQSQLELEAQAQAQTAQQATVAAMQAGYPPHQATAYGQHYAAQQHYARQQYQQYAQQQAQQQGYSVGAPNYSLPFNSSGGNVKPVTATASQKQPDSTKHTVYADDGHIIALRVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE1</accession>
    <name>I4YGE1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006957008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE1"/>
    <dbReference type="STRING" id="671144.I4YGE1"/>
    <dbReference type="GeneID" id="18473527"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59739"/>
    <dbReference type="HOGENOM" id="CLU_1230746_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGE1"/>
    <dbReference type="OMA" id="KLWINQV"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="225" mass="25646" checksum="EA5EA4EB99A78BF0" modified="2012-09-05" version="1">MSAEDSKMKLEEMAKARTNGVEVNPFEKSFIQYNTPASATAATATTNGGPLFTPGLNSFLESFGSDNSSFNPYVPQQQPQRSIHSGIEREVDRNDHNYVSPSKRKSNKKPWREVDLDDTPELMKPVGRAGNPNLHVSQDGRELSTEERKKLMLDRNREAASRCRQRKKNWINQVQDQADLLQKENAQLRDEILKYRHLVLELREQCTELKASLANKEYKNGSIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGN3</accession>
    <name>I4YGN3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956526.1">
        <property type="nucleotide sequence ID" value="XM_006956464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGN3"/>
    <dbReference type="FunCoup" id="I4YGN3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGN3"/>
    <dbReference type="GeneID" id="18473356"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59441"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="InParanoid" id="I4YGN3"/>
    <dbReference type="OMA" id="HTAFDHD"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="32979" checksum="EE4FA9D97360F926" modified="2012-09-05" version="1">MPHIFITGATGLVGSATVDELINHGHKITALARSDESARKLESKGVKVIRGGLTDFETLKQAAGDPSIDGVIHLAFVHNFDEYTQASELDVLAIKALGEPLEGTNKPFIVSSAVGGLDIESDDGVATESDLPNPAFPRKSEKTALELSSKGVTAISIRLPPTVHAGQHDKGFIRILINSAIKNKKVVYVEPSHWSAVHVSDAAKAYRLAFEAGLKGKSGIYHAVAEGNIPFKDIAEAIAKKTNAEAELKSVEDAAQYITFLAHFGLLFKPTSSEKTKAELGWQPTGLSLLDDINQHYDGTSIRDSFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGY7</accession>
    <name>I4YGY7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_56381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956621.1">
        <property type="nucleotide sequence ID" value="XM_006956559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGY7"/>
    <dbReference type="FunCoup" id="I4YGY7">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGY7"/>
    <dbReference type="GeneID" id="18472805"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56381"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="InParanoid" id="I4YGY7"/>
    <dbReference type="OMA" id="PEIIMGH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="150"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="481" mass="55217" checksum="ECBE6838F4C7B7FD" modified="2012-09-05" version="1">MTTEKKTEEDEYAFEEYDEQEQEKRAIEERRKRREALQAEYERSKKTDTPSNELTPVVGDIKGKTADNTDTIPAVDYSDKLDRPENKQPQRFDTPDDDNEDDMFALSNEHLTKKQKTTHNTTAGFTADGATDPEGYYATTLGEKLDNGRYLVFAMLGSGMFSTVVRVKDSKADDKEYAVKIIRSQESMYKAAQKEITLLERLKELDEDDKKHVIRLERTFEHRGHLCIVFENLSMNLREILKKFGANVGINIKAVRAYAHQMLLALSLLKKANLMHADLKPDNILVSENKAHLKVCDLGSAADVSEGDITPYLVSRFYRAPEIILGLPYDTAIDMWSIGCTLYEMYTGQILFAGRSNNEMLKKMMELKGKFNHKLIKKGVFGVRKQENHGHFTEHFEFISSEWDKITQQQIEKPIAISKPVKDLRARLIPSINEQKHMKEDEIKSLQSFVDLLDKMLALDPLKRISVKDALSHPFFHTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ7</accession>
    <name>I4YGZ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase I associated factor, A49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956630.1">
        <property type="nucleotide sequence ID" value="XM_006956568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ7"/>
    <dbReference type="FunCoup" id="I4YGZ7">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGZ7"/>
    <dbReference type="GeneID" id="18473396"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59510"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034953_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGZ7"/>
    <dbReference type="OMA" id="DVYPFDE"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="44457" checksum="43A669DF50F4F8DC" modified="2012-09-05" version="1" fragment="single">MTEIKILSDKGQGPALAAFGATVPPENTEFSTYTNDSNSLIAGSNDSIDYVSNDPEEQPSRYLIGLKRKNSDTITFQEAPLYVMNRQIRSLAHKSTELDDADMADRMRARNALGETFGTKKAKKAIKEAERNQVDVEAMANVAGYIQQDIAENTDILPTRENIKAEADAQRPLPPYDQSGGSLEEVYKISSLISDPEFNSCKVDKLLTAKDASAIAQLLPSGDSVNYIIERLVALKTVKGNKSSRTKVRLLLYMSYLFAFRTLGRQSRSKVQERTGAPPVIVDGLFSKFTETARGSTKSSMTPFTQAKLLNYILVLTLHVDDNSVDPSQIAKELSMPVQKINESFKSLGCQLVALNLAEREKVNVLNNQRGEESQDASKSARRATLKIPLEFPQVRRGKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH16</accession>
    <name>I4YH16_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956648.1">
        <property type="nucleotide sequence ID" value="XM_006956586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH16"/>
    <dbReference type="GeneID" id="18473404"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59522"/>
    <dbReference type="HOGENOM" id="CLU_1604024_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH16"/>
    <dbReference type="OMA" id="AGCIEIR"/>
    <dbReference type="OrthoDB" id="10417310at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="197" mass="22159" checksum="9A0C38B884B4F7C1" modified="2012-09-05" version="1">MEQVEKLRNVGMQRTHSNALDSQKFMVDCHNAGSLKKAKKIVDDALLKYQCVDIQLPLGMRPLAVGEQGEGVPVIENVDMQKEICGYLDELGVDYHIDEGVAGIIEIRRVKRIQPAIIKDVAHLTLEQAKLAVKETLEQHQRRGIKLLTGIAPSHSYEDVSNHISVKLREWLESEGRTVEEDDCHPGALYLKSEDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH27</accession>
    <name>I4YH27_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_62641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956659.1">
        <property type="nucleotide sequence ID" value="XM_006956597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH27"/>
    <dbReference type="FunCoup" id="I4YH27">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH27"/>
    <dbReference type="GeneID" id="18474769"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62641"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="InParanoid" id="I4YH27"/>
    <dbReference type="OMA" id="KDPEYTS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="99"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="26717" checksum="7517113AFA8E9F62" modified="2012-09-05" version="1">MTIKFELWSYPQGPNPFKILNFLEELGFAYRGDYIIHNLDFSQHPLKGVKGEFFERVNPNGRVPALVDHMNDHFIIWESGAILQYLARRYAPDQYLGKNLNEQMTTVQWVDFQISGQGPFQGQVVYFKHFWKNATGEDAPPSVIRRYENECYRVFAVLEKQLIRQKEKGNNFIVHDRYTIADISFHGWLRSIAKAELSFKDYPHVADWVNRMEKRPSTQRAAISLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC7</accession>
    <name>I4YHC7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIF4G-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_53636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956750.1">
        <property type="nucleotide sequence ID" value="XM_006956688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC7"/>
    <dbReference type="FunCoup" id="I4YHC7">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHC7"/>
    <dbReference type="GeneID" id="18472624"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53636"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006308_0_2_1"/>
    <dbReference type="InParanoid" id="I4YHC7"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="353"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="575"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="758" mass="87687" checksum="01F5314BCAD6B85E" modified="2012-09-05" version="1">MESPQLKRKRSNSPPRVDVNQELSTLGLNRPGGRYIPRPVLKALLESQSANDSSSADVQRLKWDQLRKSINGLINKVNTANIKIITPQLFQENLIRARGLFARSVMRAQAASLPFTPIFAALVAIINSKLPQVGELLVNRLINQFRKSYKRNDKSTCNATVMFIAHLVNQSIISDVFALELALFLLSKGGDDGVEIAVQYIKEVGAALQEREPSMNNLIYEEFRNLLHDADISKRVQYMIEVLFQIRKDKFKDNPIIPEELDLVEQDEQIVHDFDFNAPVNTEDGLNIFKFDPAYEENEEKYKSIRYQILGSSDDEDEEEEEDEEDADDEQDDAVQPAGQDGIIDKTSTNLVNLRRTIYLTIMNSLVFDEAVHKLMRIQIPPGDEIELCNMVVECCSQERTYNKFYGLIGERFSKLNKLWQECFQRCFQGFYETIHRYETNRLRNIARFFGHLFASDGISWSVLNVVKMTQEDTTSSSRIFIKILFTDIVEMMGLKAAKERFADPSLRDDFKGLFPMDHPANTRFSINYFTAIGLGAITEDMREYLKTAPKIMPQQPADESSDSDSSSVLSSSSSDVSSISRSSRARSLSRSPVRRSPPRRNYRRSRSTSSTPPRRRLSRSPSPPRQRYDSRSPPPRRPSPTSRRGAPRDGYNRSPPGRRYDDSPPPRRRYDDSPPRRRYDDSPPRRRYDDSPPRRRYDDSPPRRRYDDSPPRRRYDDSPPRRRYDDSPPRRDDNRRRRDDSPPRRSYRDISISPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHH8</accession>
    <name>I4YHH8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956796.1">
        <property type="nucleotide sequence ID" value="XM_006956734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHH8"/>
    <dbReference type="GeneID" id="18475280"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67673"/>
    <dbReference type="eggNOG" id="ENOG502SBVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1327304_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHH8"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22771" checksum="3B057A028A2719A8" modified="2012-09-05" version="1">MSSRVVDRIQKYSGIAFGGFVVLHLCAPHAGALLGPNVVDDVVMIGRTLYHQPYIEYACIGGSLSVHIISSIYKRMKRGTSKRVSAQNKTGWVLIPLLFGHTLIHRVIPAMDVKPIRSLSPSELSYAHYVGHALTTRPLFSIIGYTSLTALVIYHGLVGLMVKRKKVKHAVTVNIAVIGIGLARIANGYTPDFMTGRYEAVYNQLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHJ2</accession>
    <name>I4YHJ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">WALSEDRAFT_15711</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956516.1">
        <property type="nucleotide sequence ID" value="XM_006956454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHJ2"/>
    <dbReference type="FunCoup" id="I4YHJ2">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHJ2"/>
    <dbReference type="GeneID" id="18470671"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15711"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="InParanoid" id="I4YHJ2"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="171"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EIM23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="453" mass="49382" checksum="F4CEC19FCB9A84BC" modified="2012-09-05" version="1" fragment="single">VVLSFGSNLGNQKLNIQKALNLLESRGVAKVVDTSFLYQTKPMYVIDQPTFLNGVCKISTSLTPHGLLKSIKEIEEDLGRDLGGPVKGPRPIDLDILVFGDQKVNDDVLNIPHIGISERSFVLKPFCDVLPDFIPPGHLLTSTEALQRLNDDSIKMALAVGQKLISLRDKRWVMGILNCTPDSFSDGGLNYTLEDSYKNAVKMIEDGVDFIDVGGMSTRPNAPDVEPEVEIDRVVPIIAKLRKEYPEVIISVDTFRAAVAKAAVEAGADIINDVSGGLADEDMFKTVAELGVPYILMHMRGDSRTMTSLTHYSEGVVEGVKHEMQERLKMALESGIRRWNIIIDPGLGFAKDVDGNLDILRNLDAFGGRSTKQDNKSNGFLTQEAHLELANMPLLIGHSRKKFIGTITDVGTAKDRVAGTAATTMAALSGGADIVRVHDVKETIDVTKMAQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHR3</accession>
    <name>I4YHR3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_56116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956182.1">
        <property type="nucleotide sequence ID" value="XM_006956120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHR3"/>
    <dbReference type="FunCoup" id="I4YHR3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHR3"/>
    <dbReference type="GeneID" id="18472772"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56116"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042567_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHR3"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008092">
        <property type="entry name" value="Ribosomal_mS29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01716">
        <property type="entry name" value="DEATHASSOCP3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="428" mass="47648" checksum="BB72AA91BE235BF2" modified="2012-09-05" version="1">MASRAARIALSYPSRQFTTSAVAHLPPKKGQTIKKTANSFTKKNKGGNKLKTEAVSHSGRYEKLQATPPDLSFMPEFLPERITDKSIGTPFRFTKDALNITKFTGIPPTLAREFATEREAHTVIRKSSINAINKLDSASKTSSKDNRYVLHGKIGSGRSISLLQSVIYAQQSNWLVFYIPKSQHLVDSSYAYNPPSESGGIWTQPSLSAEILRIFAETNKEKLNDVKISQDYDQFKAGDKIYDLCIHATKYENKAVETFDVVMNELSKQTAHPVLLAMDSIQAMYQPTLYKDQHFNKLHPYELSVTAKILDFLSGRQQFNRGAILGATSSTPTTMQIPSLLLAQLGLQPEKPINPFEKWNTKHLNNANGLKLIEMEELTFAEAVGVFESFGKSLGISNPMSDELLLSKFTESGGSPKAFTRSLRDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHX8</accession>
    <name>I4YHX8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956245.1">
        <property type="nucleotide sequence ID" value="XM_006956183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHX8"/>
    <dbReference type="FunCoup" id="I4YHX8">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHX8"/>
    <dbReference type="GeneID" id="18474726"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62240"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049943_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHX8"/>
    <dbReference type="OMA" id="WRRTDQT"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="295" mass="33926" checksum="09D4E8C2CC1ACBCC" modified="2012-09-05" version="1">MSTSWVTVVTTSTYIIGAKVLNASLKQSGTKYPLLVLTTDALSDAEQQECRDAGMEVKLIEPLLLDTVAAGDFRAAFAEAGNKLRAFALVDYDRLAFLDADTLVCRNIDWLLDTADLIDDDELAISFACTCNNRKKSFYPASWTPENCGHNNITYSHSIPLTKLTDDNVAVNSGVMVFKPSTRICNLIENFIFNNQDLVQTYVFPDQQILQDVFRQRIRILPWKFNSLKVLRVCHKNLWYNDESNRDVHIVHYIHEKPWNKRCKSVAYPNNLPDWHEVDVDPTHAWWWHTHDNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY3</accession>
    <name>I4YHY3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apoptogenic protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_62245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956250.1">
        <property type="nucleotide sequence ID" value="XM_006956188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY3"/>
    <dbReference type="GeneID" id="18474728"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62245"/>
    <dbReference type="eggNOG" id="ENOG502SD1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1723742_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHY3"/>
    <dbReference type="OMA" id="DTREYQW"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="18157" checksum="B726067A5559902F" modified="2012-09-05" version="1">MNFTVIRRGITTKAGIPTTLVGPSSVHSHLRPVRYATNEDSKPNHHPYEPTNNFYEYSAEELSFDLSRRRLDNFNERFWSDNNIRCEQAMKAYVGDAQGEERQVLLQKFWMDWSEANKARYLNWSKEWWKSQLSLLYPAFKISVKQLYRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI33</accession>
    <name>I4YI33_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956295.1">
        <property type="nucleotide sequence ID" value="XM_006956233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI33"/>
    <dbReference type="GeneID" id="18475229"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67262"/>
    <dbReference type="HOGENOM" id="CLU_1887356_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI33"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698191" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="15655" checksum="2AAB864F81476229" modified="2012-09-05" version="1">MKFSIALATTAAILSVASAVPVYLERRDPVYLERRGAGARSASVRRGALDEALPTKRGVLTRDEHDHHDDHIDFHHLSHDEEKALYQTGDYYPELFSEEAYDHKAEHKSEEKHDDKHDEHDDKHDEHDDHEQEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI34</accession>
    <name>I4YI34_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956296.1">
        <property type="nucleotide sequence ID" value="XM_006956234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI34"/>
    <dbReference type="GeneID" id="18473277"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59298"/>
    <dbReference type="HOGENOM" id="CLU_2442548_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI34"/>
    <dbReference type="OMA" id="MHARIAF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="9990" checksum="FFFCCEF5D484275A" modified="2012-09-05" version="1">MLFRLLFVVILVFLLAIVLAVILFVILSIVLVVLLIIILIIIFTVILSVTLIILTAIPLVFSFLIIMVLVGVFTPEAFNPFTFLNGFLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI40</accession>
    <name>I4YI40_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956302.1">
        <property type="nucleotide sequence ID" value="XM_006956240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI40"/>
    <dbReference type="STRING" id="671144.I4YI40"/>
    <dbReference type="GeneID" id="18473280"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59302"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_6_0_1"/>
    <dbReference type="InParanoid" id="I4YI40"/>
    <dbReference type="OMA" id="PKYCGRK"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697822" evidence="2">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="119" mass="12050" checksum="6B92E06164F10A8B" modified="2012-09-05" version="1">MQFSLAIATLAAAATVSAVPVKRSGTGTFYYTATGSAGSCGSYLNDGDSIVAVSQSDMNSGLCGKQVTIQNTSNGNTATATVQDTCPGCGSGSLDLSPSVFSQLGDQSEGTLPINYWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI42</accession>
    <name>I4YI42_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_35214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956303.1">
        <property type="nucleotide sequence ID" value="XM_006956241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI42"/>
    <dbReference type="STRING" id="671144.I4YI42"/>
    <dbReference type="GeneID" id="18471905"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35214"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029378_3_1_1"/>
    <dbReference type="InParanoid" id="I4YI42"/>
    <dbReference type="OMA" id="THQPVVM"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="204" mass="21603" checksum="B2C7CF4200FF5D89" modified="2012-09-05" version="1">MPGLAQDGQQAGAEAGQVASLTSTNNFINFCLTEPDLPLTNGMQVRGGSCNPVPIGVVAPTNKMPSAKFVNPKNGDTIPANQDFTIQMAVRNIDTGNFVNPNTNYFAAPQTTNNNGIIVGHSHVVVEELPNLETTQPLDPTNFAFFKGLNEEAQNGVLTAQVSKGLPAGDYRMCSINSSANHQPVIVAVAQHGSLDDCSYFTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI44</accession>
    <name>I4YI44_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidative stress survival, Svf1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_14834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956142.1">
        <property type="nucleotide sequence ID" value="XM_006956080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI44"/>
    <dbReference type="FunCoup" id="I4YI44">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI44"/>
    <dbReference type="GeneID" id="18470644"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14834"/>
    <dbReference type="eggNOG" id="ENOG502QQY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030205_2_0_1"/>
    <dbReference type="InParanoid" id="I4YI44"/>
    <dbReference type="OMA" id="WGEMRHR"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="201"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="401" mass="44474" checksum="9B7F7AE55756788A" modified="2012-09-05" version="1">MFNFGSAEKVKNLHPVTEEFESSQYFGPLTPKDTEWATINSNFVAETQTFWYPQIQFNFMLYNPTTANKLWKSISVNNFSTPAKVPGKSYDRRSCSADQFTILHESLPNGDESYRINAKIDNEVQIIINFIRPASCAGFKLGDGPEGGYTSYGNDKSSNKRDGYVVHRFWPRVRTEGQVIIKGKLVDAVGHGAFIHAIQGMRANLVARSWNFALFQSDQHGGVSSLLMEFETTDGYGLATRTEGGGGVKVTIGALVAGDKLLSVTGSTTYPGQMPQGLTAAEYRNTIKDQETAYIVPSEVRYVWGGAAIENNKAIRAEMLVNYKNEKEEGVNRGLVEKVDFLAHIPYVVRKAVHVFAKTKPYIYQYLNPAELQLDLPEGVAEATKLTVQGTAFTEQSFISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIB0</accession>
    <name>I4YIB0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_67327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956368.1">
        <property type="nucleotide sequence ID" value="XM_006956306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIB0"/>
    <dbReference type="GeneID" id="18475241"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67327"/>
    <dbReference type="eggNOG" id="ENOG502S8RC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427735_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIB0"/>
    <dbReference type="OMA" id="QVTHPRI"/>
    <dbReference type="OrthoDB" id="3358962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="73276" checksum="0CFE03DD1E205F09" modified="2012-09-05" version="1">MEQHIRLLALGFSYANKAKELATEIYAEPHKLAHYQRSCYLSILSYRASLEIQGLSPQQELNSRLGLGRALYDFTSDISDAEHVVSRGLSKASEDDSLDDYLFRFYELHINISASKNVKFAQSLLKRATKDAERKKRKEWIYHFNFLAAKYSTNPLNFLRTIVDLAKKNHDTSLHHLGLAEVARILANNSDWKGCGIVLKDLEMEINLLPDSNKPANEEAPDKMDEDIKQSSSTNERGLREYILVVFLVVKVIFSSHNADADTAKKRLEEVQHLIDETQDERYFEMSVNGCSDKVVYQAPTKSQLLDFSFVLSCMTCKDPVGTKPLSLLYSLKAIDLFNEDRREVYRYSTIQNIEKRNVQRVHMKLYILCSLTQVYIMRREMENAYKTLTEMVKLSREHSLTMKWAAWMLMLEGYYLQASNELEAAKVYYESVISLCGKKGDTFSNLFLTNKNSVQNLHNDEMEVAAKLSKLALEVGTNNAEHDRMKELNESSKLIQCSSSILAALRMVEGMLNKSIITRSKYLLSQSLTLSSKSNDNHIRAFLFALLSEAFNHSHEDQALKMIETGYALARKMGKVDQASSKSYGMPFLNLFYGKCIADHYKRNGMQSELNKQESLNQFYTKCCNRIASNGFDKSIEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIG3</accession>
    <name>I4YIG3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">V-snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_62424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956419.1">
        <property type="nucleotide sequence ID" value="XM_006956357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIG3"/>
    <dbReference type="FunCoup" id="I4YIG3">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIG3"/>
    <dbReference type="GeneID" id="18474749"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62424"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075474_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIG3"/>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="121"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="25386" checksum="FE4DAD5B07B5EFD6" modified="2012-09-05" version="1">MTSVELIDNYFLDYENIIDTVSNKLYTDISAQSGLERKSTLRWLQNELNEADDILTQIEFEIPSLAAEFKDHYQSKLRSNKSTLSKLKDETGRLLDSSDRHELLAGSSDSPYYDDQQERQDLLLDADRMDNTNARLENSHRIALDTEDVGAEILRNLRQQREQIENTHNTLGEADTGIDRSMRTLKKMWRHSIKQKAVTWLIIGILVLLILIVLWGKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIG8</accession>
    <name>I4YIG8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_53459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956423.1">
        <property type="nucleotide sequence ID" value="XM_006956361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIG8"/>
    <dbReference type="FunCoup" id="I4YIG8">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIG8"/>
    <dbReference type="GeneID" id="18472615"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53459"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIG8"/>
    <dbReference type="OMA" id="CEPEDAP"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="34019" checksum="EC1ECE350F175003" modified="2012-09-05" version="1">MGTPNAQLLGSKIVFVGNLPYDINEEEVVRIFSEVGPVKDFRMNFDKHTGKPKGYGFVEYYDGDTAASAVRNLHDNPVGGRPLRVDLAPDDPKHVKQKEREKHHNNMSSGNYAPLPPPPTAARMGIDMAPGQSATDSISQTLASLPPNQLLDILSQMRASVHTESNSVRQLLNQNPQLSYALFQAMLMMNLCDNTVLQVQLTYNLQRLMPNQQAPQMMNPTPPPMMSTPAMYQQPPQPPMYPRTHTPTYAQPPPAQDPIQAKVQALPLDQQAMVMQVLSFTPQQIDALPPDQRMSIVALRQQFGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIQ3</accession>
    <name>I4YIQ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955691.1">
        <property type="nucleotide sequence ID" value="XM_006955629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIQ3"/>
    <dbReference type="STRING" id="671144.I4YIQ3"/>
    <dbReference type="GeneID" id="18473098"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58969"/>
    <dbReference type="eggNOG" id="ENOG502S5ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507353_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIQ3"/>
    <dbReference type="OMA" id="AFPCICT"/>
    <dbReference type="OrthoDB" id="2586454at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59654" checksum="F055C4CF02233081" modified="2012-09-05" version="1">MGSAEIITLDHAEPTHSSSPLNRLQQSPSHSSLGVSKLLSLPAINLHLHSSIVFLHPRSNENNDEDDDSSINLPPPASEDEDVIRGVVELYLPSSRKIHGIEVRLIGSQCINFPSGAYETFPVLDKYVEIDKTYLEKGTHKFEFSIIIPSSTPGYERCAYGRVYYYVRAKAISAGPLGFDLTDSREVLLVINPNPAGEPSGLSWHHDQIIDGLGAMSIDLESTHLTIGGPVHLRLHLHEPPKGATLHCINVSLLQYITLRNKDRSKEEKAPAVAVKFFQIGSRKHEPLLNPYEEVDEDGWKHEWIGRLPDDDHARPTTVKTNKTSIIISHQLLVQIFVTPSNLDGEHKDKDDKSQMKVVSIRRPIFVSSCCVSLDSITLPAYEEVAPNQDIMYECACGQPLQSLIAKETAVPAQQGGLQGSSTDLSNALIPIAQEQEDEEKARPTDERLGRTHTRFADNYVSRQQSRDSSLNRNTRSRSRPASINSPTIEPSTSSQSLTREARSRPRNWFKRATSRSNSRANSQANSRAPSPVRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIR9</accession>
    <name>I4YIR9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_55803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955705.1">
        <property type="nucleotide sequence ID" value="XM_006955643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIR9"/>
    <dbReference type="FunCoup" id="I4YIR9">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIR9"/>
    <dbReference type="GeneID" id="18472742"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55803"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_1_1"/>
    <dbReference type="InParanoid" id="I4YIR9"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="45549" checksum="8A7CB7C6475DF4F2" modified="2012-09-05" version="1">MSEEVPKELESMMGESLLSVITANNPLNQGKDFRVRKWRQSEISNPGRSDDLKASIWKRSDEDDDQVFSFSEYNTSSQAYSYSQDEYDRMLQDITWSKDETDYLVNLIHEFDVRWPVIWDRYEWRSGRTLEDLKARYFDICRKLIQSRISTDESSTNQLLSAYQFDKGMFARYLGDPVNLLVEREMLRKQYLNSLLTRTPQQVEDEELLYIEAKRIEQNERKWRSERDELFRTVSMSSRDEKRKADAAITGASEENITKRTAKNTAFDDQNYITHTSSQLPLKTSSSNIPPYSRATKVSQKITLQRIKESLNEMGLADKLQYPTANNVTRYESVKEAMSQLLEIRKAHEKVASDLNIAKGITPPNVASSPAPAQAPERSMSVDSNDPNKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIV9</accession>
    <name>I4YIV9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_41979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955743.1">
        <property type="nucleotide sequence ID" value="XM_006955681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIV9"/>
    <dbReference type="FunCoup" id="I4YIV9">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIV9"/>
    <dbReference type="GeneID" id="18472238"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41979"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019618_2_1_1"/>
    <dbReference type="InParanoid" id="I4YIV9"/>
    <dbReference type="OMA" id="KLITHQY"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="25"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="541" mass="61069" checksum="AA2B4BD56E66324E" modified="2012-09-05" version="1">MEIQEVTSAEFKVTDQRPDQKTRRYDRQLRLWAAAGQSALESAKVLVINGSATSSATLKNLVLPGVGHFTIMDHHTVTEADISNNFFLEPESIGKPRATEIVRLLLEMNDSVSGEGLVKNPYEVIETQPEYFTNFSAVMIHNPKSDLTSKLAELAWNNHFPLFVMKTTGFYASLRVQLPEQTIIDTHPDTIVDLRLNKPFKELTQFANSIDLEKATNNEYAHIPYIVLLIKELDMWKKTHTGALPKNLSEKREFKKILDTRRRKGIDDQNFDEAQSQAYRAFQSNDVPPEIATLFDDNSLKSLSKNSSPFWFLIAALREFTERHGVLPHPGTLPDLHTDTQTYVNLQSIYKNKAREDVNELKEILKGIVDKFAISIENFNDDIIASFAKHSGYLKVIKGSSIKDEYTSPNRDLVSNGLNDEFIASAFAIYIAFLTSDAFRDQYDRHPGDCALEEYENDKQKLSEELNRLTNELFDVQPSQVVINAVEEVLRGGGGDLPNTAAFLGGLASQEIIKVITNQYIPIDNYCIIDLVKSTTTVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ38</accession>
    <name>I4YJ38_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955815.1">
        <property type="nucleotide sequence ID" value="XM_006955753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ38"/>
    <dbReference type="STRING" id="671144.I4YJ38"/>
    <dbReference type="GeneID" id="18475163"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66857"/>
    <dbReference type="eggNOG" id="ENOG502S8HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627873_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ38"/>
    <dbReference type="OMA" id="SSCTITX"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47241" checksum="7CFF00F8A8FAE335" modified="2012-09-05" version="1" fragment="single">PVESSQPAENAETDAVDSSEKVISEPTETQTAETAENTVNANSAEQNTEESAQEKPQTVKRVVKRVVRASAPAGDGKAPPARRPAGATTATRTTTSTTRPAATTRTAPANGAARPGHASRTSVSRPATTRPAGAPTAGTTSRPTPTTGAATRRTTIGTTRPSVNVKENKPPVPRVVRRPAAPGAPPKDDAEVAKLKAHITELEQQLAGHKGDQKEVQDNHDVVVKQLDENKALVEGLNKEIELLKTQAGDQEKLASANAEELKRLNEELESAKSSLEESNKKAEHAEQSNQEIQRLQNELASIKTEQLNKQEAEASSQSEKAAQAAKQEEELASLRESHESAQKSLTEATTQLEEANKRVDELEAHARTVNDSAQVENAELKSKIEELRKLTDDRAEIEESSKQKDVQLTQLKEQLDNLSRENEEIKNATPAEDPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ59</accession>
    <name>I4YJ59_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_66874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955835.1">
        <property type="nucleotide sequence ID" value="XM_006955773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ59"/>
    <dbReference type="FunCoup" id="I4YJ59">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ59"/>
    <dbReference type="GeneID" id="18475170"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66874"/>
    <dbReference type="eggNOG" id="KOG1436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_4_0_1"/>
    <dbReference type="InParanoid" id="I4YJ59"/>
    <dbReference type="OMA" id="IYGTDTR"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="75"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM24001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="480" mass="51770" checksum="EA0DF65F4F1637C8" modified="2012-09-05" version="1">MLGALSRNKKFIKPLFYVSLGGVAFYAQDSRASIHNWLTTPLLHQLDAEDSHKLAIKLLSLGIHPKDYGNDWEGLKTTVWGKHFDNPVGLAAGFDKHAEAIDGLFDLGFGFVEVGSVTPEPQSGNDKPRMFRLEDDEAVINRYGFNSVGHLTVLARLRQRLRKFITSNADTETTNTLLQSGLFSANEATTHFGLPSSLRNGRILSLNLGKNKTTGADDVSDYVKGVKTLGPFADMLVINVSSPNTPGLRGMQRRSVLENLLSSVVDERQKLSNKLPILVKVAPDLGSDELEDVGLAAKNVGIDGVVVSNTTIDRPSSLTSENKTQVGGLSGKPLLEKSVKALKELYISTDGQVPLVGCGGISSGKDALKFAGAGASLVQLYTALGYQGVGLPRRIKDEIADELKNNGIASWQAFVGTDALADLTQRRWEKGYSAAIDTLTKEVEGLIERAKKLADVDTNSAQGIIQKGTSTAQEIQKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ91</accession>
    <name>I4YJ91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_30803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955866.1">
        <property type="nucleotide sequence ID" value="XM_006955804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ91"/>
    <dbReference type="FunCoup" id="I4YJ91">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ91"/>
    <dbReference type="GeneID" id="18471188"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30803"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="InParanoid" id="I4YJ91"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="185"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="427" mass="47041" checksum="2381F971A2D88DD3" modified="2012-09-05" version="1">MSGAVQPGSKGKVLLAYSGGLDTSCILVWLIEQGYEVVAYLANVGQEEDFDAAREKALKIGAKAFFCDDLRREFVEELIYPAVQANCIYEGVYLLGTSLARPVIARGMMAVAKREGCDFVSHGCTGKGNDQVRFELAFYGLNPEITVIAPWRNPEFYDRFPGRSALLQYAAEKGIPVTQTQSKPWSTDENLFHISYEAGILEDPNTTPPADMWKLTNSPQKAPEEPEDITIEFAQGLPVKLNVAKTGKTHTDKVDVFVTLNALARNHGIGRIDIVENRFIGLKSRGCYESPGATILRAAHMDLEGLTLDRNVRSLRDQFITPQLSNILYNGYFFSPERDFVVSAIPASQKTVNGEVKLKLYKGNVIVCGRKSDEGLYDESAASMDELGGFLPTDTTGFIAIESIRLRQWAKAKAAKGQSGIEPTDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM8</accession>
    <name>I4YJM8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955991.1">
        <property type="nucleotide sequence ID" value="XM_006955929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM8"/>
    <dbReference type="STRING" id="671144.I4YJM8"/>
    <dbReference type="GeneID" id="18474700"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61997"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013988_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJM8"/>
    <dbReference type="OMA" id="NLIYCEL"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="127"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="697" mass="77614" checksum="7FBB0563014EC9FA" modified="2012-09-05" version="1">MPKQAPDFRARKQAASNSTNTSFKARSVALPGQSILKDIDENEPRTKRNLTLKDLIIHMKHYSANVRKDGLLGLRELITNYPSTIQPNLSTIIDGITRIIVDEDAGVRKTLQSFVSELFPRIPAQSWTPFSPILLLFTASGLSHIFPEVRLDSIKFLDILIDFIPDFVVQGWAGRSLSNNVTSIGGRQIIECYMALLNAKGDDKGPAGGSTVTTTANAMFTLSINSRLVVLKSLSKFLKTALVSNDNNERLPLWPFASAFPSQTSLNAFNERIYRSGQRDVETQTIQWKESNGGREAAWEEYLNGYSADIMEISDGTTLEELNNAVMSLSSAETESSATQSEADVLSLSRSMFSVIISVFLESAPSVFTMSGTSTDSVHLESVVSVVEITRELYGYLLRNSINKVDSGKELNNILTHMSKYFPFGGDFVQKQTLEIEQQMLKLNTLYCELVSCWILSKFSNSKDNSKAKTDSINWEKGMKTQVDRVCSWLSSMLNGTMTTSAQPLGVTISVDTYKSLIPSFWALLNLPPTESASEVILDALITHCAQTGIKSDTKTLSVDFISRVYLTQFEITYQGLFKLLNNSKQDQIFTKWFNNLPKLLWEANNYNLALTEVILDTIQAVVIMDVSGESKKTISPGLKLFFEAKHPSKGSIPGPWTRINDEYIHKRGIELAYLTGISSIPTEEQYWISLSQSHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJP8</accession>
    <name>I4YJP8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_34792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956010.1">
        <property type="nucleotide sequence ID" value="XM_006955948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJP8"/>
    <dbReference type="STRING" id="671144.I4YJP8"/>
    <dbReference type="GeneID" id="18471883"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34792"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075864_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJP8"/>
    <dbReference type="OMA" id="THRIAAW"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24351" checksum="8ED642F7ACDF467D" modified="2012-09-05" version="1">MSYYFIQSREIVDRGSLFIANICSVTSDKDTIAQINQIAQAKYQLRQSRNSEPTHSITAYRYLGLKPRKSGLSEDDFTLKSGYDDDGEKYAGKRILEQITTKTPYGQTIDALIVVSRWYGGQMLGPIRFEHIKNLCKEVCDEMRNQEELREKVNTLTSLDDNITELRSKLGMENKSQNYDNLDNAKAERLIKARRGTLDVLKKKLSNRVDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J0</accession>
    <name>I4Y5J0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960729.1">
        <property type="nucleotide sequence ID" value="XM_006960667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J0"/>
    <dbReference type="STRING" id="671144.I4Y5J0"/>
    <dbReference type="GeneID" id="18473077"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58855"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_1"/>
    <dbReference type="InParanoid" id="I4Y5J0"/>
    <dbReference type="OMA" id="QNWFSWR"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="362" mass="40779" checksum="9E7CFB02EB2B7D70" modified="2012-09-05" version="1">MIVEPKSAKVHSGINIAYATRGNPAQRAILLIHGYPQTRHSMTKLQNLLSDAGYFTVAVDYRGAGGSSITTDGYEKMTMSADLHSLMMDVFGCRKYTVLGQDIGAMIAVAQAMQFRDSVGALVFMECPLPGTSQYDLCVKDRNIASDDIFHFFFHQPRDLPELLTQGKESQYLQHFYDRLSFKPGCMSKDDVDEYVRAFSRVGRMRAGFELYRAFRRDEQDVKANLAEFGKLSIPVLATGGEHSLFTTLIEGMAAEVAYQYDFGRVRDSAHWVSEENANALSVYENVLWLEGYFHYPKRNNGFLVHPLKCLEFMTIVHPRVSKLLRSTSFGGLDGYDFGLISYESLLGMQSEGPWFESAPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5K2</accession>
    <name>I4Y5K2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960741.1">
        <property type="nucleotide sequence ID" value="XM_006960679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5K2"/>
    <dbReference type="FunCoup" id="I4Y5K2">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5K2"/>
    <dbReference type="GeneID" id="18474619"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61580"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060354_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y5K2"/>
    <dbReference type="OMA" id="DYADQEM"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="24041" checksum="29ADB346B5E9BA39" modified="2012-09-05" version="1">MSIISIRDVQVGNPIARWSDPFKFTVTFECISHLPEDLEWKLIYVGSSSSVNFDQELDSCLVGPVPVGVNSFTFEADPPSVDKIPKEEILGVTVLLLTASYRDQEFVRVGYYVHNEYDSDELRENPPENIAFDKLNRSILVEKPRVTRVAIDWGTETKGAVANGSQLPPVPAPATFEELNDVALQEKEEKKTEEKTSPKKEVNDGKENKSAEIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5K7</accession>
    <name>I4Y5K7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_41642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960746.1">
        <property type="nucleotide sequence ID" value="XM_006960684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5K7"/>
    <dbReference type="FunCoup" id="I4Y5K7">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5K7"/>
    <dbReference type="GeneID" id="18472223"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41642"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5K7"/>
    <dbReference type="OMA" id="WTQTQQQ"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="42642" checksum="BBA27C80CF1AEA25" modified="2012-09-05" version="1">MSTEYKFTCQGCGLAFQMAEDQRNHFKSDLHRYNMKRRVTGLPPISSEQFKQKFEDSTAAKPTVVQSKPNHIKEKNYNPTKVANKQPEDVKIQPELTEEEIYNERMKNRLSSLDCLFSSHKSSTVEENVRFMEHNFSFYIPDRDFIQNLDGLVQYLADKISIGHTCLFCNKSFTSLESIRKHMLDKSHNKIAYELEEDRDEISDYYDFESSNAQNDDGWEDDEDIQSGEEDEMVEDDSDNKEEREIQYGDTPFELVLPTGRRIGHRSMQMYYKQRPLQQELTEKKHGQQSVTYKMSNSDALIPAKGSGFGAFGEGQQVIHASNKGEARLAKKATRQARDVQRREQFKTKVGFKHNNQKHFRDQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R3</accession>
    <name>I4Y5R3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960697.1">
        <property type="nucleotide sequence ID" value="XM_006960635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R3"/>
    <dbReference type="GeneID" id="18474604"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61558"/>
    <dbReference type="HOGENOM" id="CLU_3034141_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5R3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="55" mass="6445" checksum="08C278C1B85287A1" modified="2012-09-05" version="1">MLDRTANMKICFVYLLDPNSPQKTRSREHSSVCESWTLSIKHRRKAKHIKSEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5T5</accession>
    <name>I4Y5T5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terpenoid cyclases/Protein prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960603.1">
        <property type="nucleotide sequence ID" value="XM_006960541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5T5"/>
    <dbReference type="FunCoup" id="I4Y5T5">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5T5"/>
    <dbReference type="GeneID" id="18474574"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61511"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y5T5"/>
    <dbReference type="OMA" id="RWCLMRQ"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="4"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="344" mass="38185" checksum="75A0C6707CAD785B" modified="2012-09-05" version="1">MEGTAKFSFRHLELLPNVYESNDSARLTLAFFVVESLAILGESLEKASEYCDYVYKCQLPYINGGGFRGSLFMGKQEYDNDEIPPYDPSNLTMTYTAILLLALLRDDFSRLDVKGIIRSIEDRQKPDGSFAPIPSGSESDIRLVYCASAISSLLGDFSGIDIPQTIAYIKRCRTYDGSYSQTPNGEGQGGTTYCALASLELLSSQIPSEQLISHKESDETLRWLSQRQIHGFQGRTNKDCDSCYSFWCRGAFESLKKLSNLPDDLEIFSDELDGDFLLSCSGKLGGIAKYPNEYPDVLHNCLGLSALSMAKSRSSSATTLKSINSTINIEITALEWLKSRINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X5</accession>
    <name>I4Y5X5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_70705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960643.1">
        <property type="nucleotide sequence ID" value="XM_006960581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X5"/>
    <dbReference type="GeneID" id="18475776"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70705"/>
    <dbReference type="HOGENOM" id="CLU_573910_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5X5"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="353"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="476" mass="54826" checksum="A25F415CB328AEDE" modified="2012-09-05" version="1">MIVLDYKNYRIWEKQLFYFAHTYKYRSILDGDVDESNPASLEEWDNPNYTDVRNLPNEEEINYFEFSVLPKSCVTEPEKELMERRLKSNLSDKQLSEYYRRFLILSEHLRDSIPEDLQVDILHLNKPHEIFKYIASRYQEDDSLISHSHESIPKDLQAEDFHIHKPHEISNHTTFKYENIDHVAVNHNLRYLMGMKFTYGTDLTKFFAEMKGIWAKIRDPEPYRLMPVDILRCTVLLAMPKEMSDSVEIAQHLCSETNSPQNLMDELIRLYNTYHKDARNSQSSTSSSDFQSSAKCNFCLLRGVKKVNHSSDACRSSRALQDLLDPDTNSPEIPEALNHTTGTSHDPESAIFSTGVSLHITGRRDLFVDFITIPPKSIRGINGSIIQATGIGKVRFQYAVGKSIKTMELNDAYFVKDSLNTLISVSSFSRNKLSVLFAPNLNFGLLLNAKLHPLFKIPVTDGLFKIKICHLHKLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y7</accession>
    <name>I4Y5Y7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960529.1">
        <property type="nucleotide sequence ID" value="XM_006960467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y7"/>
    <dbReference type="FunCoup" id="I4Y5Y7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Y7"/>
    <dbReference type="GeneID" id="18474552"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61473"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015642_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y7"/>
    <dbReference type="OMA" id="YVRSTWA"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697423" description="Hexosyltransferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="59440" checksum="20C806FDC4ED17D5" modified="2012-09-05" version="1">MQPLVLIFALSLTKFLMWYLNPDKNPLPWRTYCQDTLSFPHELADSLAPVTILVGVMSIDRSAERRNVIRQTYARKASPRDGTHVQVIFFIARSRPSLRHAIHLEQETFGDLVVLDMKENMNSGKTFEFFNWASKHAWIPDPATLPSHLISYPSAYNHQDTNAHERVIQQPNEDGFDVKLDNLRKEYQRGYQRDHHDINNDDPSQHISNYVPGTGVKYKRPDFVVKADDDSFIILGELERHLRILPKKLVYWGYLIKNRFMGGQAYALSFDLVEWIASNNFTRGHQIGAEDNLTARWMKHHPKANEINWVSERCWIYNHPRTHTVYSHGFLFPSEVTRVKEEAIPGSVSIDEQIRRGQGNRNHSEAYSTVFKWGKEYEEPRKHLSVVDRVAALVEGADESLNSEEKKHGVVGLPRQSLSERYEGRPWGGTIIVHFIKRHEWFYETALAFLTDWSLIPHSKPIASKNYWTKTNALHNKDDDFDRQRGYRLIDITDGADVYRFRTSLEPFPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y603</accession>
    <name>I4Y603_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">L-serine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_70626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960545.1">
        <property type="nucleotide sequence ID" value="XM_006960483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y603"/>
    <dbReference type="STRING" id="671144.I4Y603"/>
    <dbReference type="GeneID" id="18475767"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70626"/>
    <dbReference type="eggNOG" id="ENOG502QVSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y603"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="303"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="607" mass="65970" checksum="D87D1F02CC2BF239" modified="2012-09-05" version="1">MISRNRYNLARISRSTHAAFSTRSSTSASAFGRTRASLLSEISGTSGYFPNNRRLATVATAQSSNQSTQPESQTSENTPPKTEHAVISTFDLFSIGFGPSSSHTCGPLRAARIFVNDLADNGVLEQAHSLKVTLYGSLALTGKGHMTDMAICWGLEGVDPEDTSIDASSLPGLFDTIVKNKMIILRNESEEKEVYFDVEKDISWRMNEALPRHPNAMQLSTFSQSGDLLATNTFYSIGGGFVVHDNTEITENVFYKSIKKDAVDPARRNVHLVEEENTSDVVKHKDVPYPFHSGEELLNLCKKHNLTIAQIVYNNELTWYTPEEIDSRLRNIWKTMDESILAGISATDEYLPGPLKVKKRARMLYDRLQSGLYNRTSIGSSSDAAIVGDWSHPLKPIPPRRNNEVKSIDFVMCYAIAVMEANACASRLVTSPTMGSAGVLPAVLKYHLEFLSHDPSNDMKQFLLTGAAIGMLIRRGATISAAEGGCMAEIGSATSMAAAGFTALNGGSTKEILQAAECGIEHFLGVTCDIPHGLVQVPCVERNFLGAIKALCAAQLSLNTRGEHVVSFDMSLKAMRDTAALMSTQLKETSLAGLATSVKIPVSVPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y670</accession>
    <name>I4Y670_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960494.1">
        <property type="nucleotide sequence ID" value="XM_006960432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y670"/>
    <dbReference type="GeneID" id="18474541"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61457"/>
    <dbReference type="HOGENOM" id="CLU_1027464_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y670"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="271" mass="32140" checksum="97964064F37EF570" modified="2012-09-05" version="1">MAFSDEEVEKINKFMKNMPVEKFQPSQEVLDSLQMLSVVEEENALPEKDKEINKSTEYRELHKELLDLNADVKLMKRKIKHLQKGIKVDEPPKSEKERKIAATVATMKLNKRLMKKILKNTMRSYARNTVVSTSAHFEQDKVSNPDRLIGLIDQAVDLDLQVMYRIVEIRKTMKDTEFFTRELNKNIQTLKAESKRIFELDKEIENKAINQLNEQQRKKHKRLKQLTKRQRKLRIIDGNILQCLIMEIFPRWANEPLWLESLEKFGDKLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6F1</accession>
    <name>I4Y6F1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">kynurenine--oxoglutarate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.7" evidence="4"/>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960466.1">
        <property type="nucleotide sequence ID" value="XM_006960404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6F1"/>
    <dbReference type="FunCoup" id="I4Y6F1">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6F1"/>
    <dbReference type="GeneID" id="18474534"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61441"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y6F1"/>
    <dbReference type="OMA" id="PRDFKLC"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000021">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="33"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="425" mass="48042" checksum="EE60F177099EFE5F" modified="2012-09-05" version="1">MSVRPASRIAFELNKSADVWSIFNPLVMPKTSLSLGQGFMSWKPPSYIRSALNNSINEDTSVHHYSHPKGRPRLRNALSEHFSPEFTCLNGRKLDTESEIIVTAGANEGIYSILAAFLEQDDEVILFEPAFDQYMPNVRYNGGKEVYVPIRFHGDPTKNSTGDDWKIDINELRAAITPKTKAMIFNTPHNPIGKVFNEQELNEIAQVAIDNNLLVISDEVYDCLTFDGSKHLKIANIPGMWERTLTVGSAGKSFAATGWRVGWVLGHPELIKATLAATVRIVFCVNSTAQEGAAIGLEQSKEQNFFHNQREEYEVRRDTLTKHLDSIGLPYTKPSGSYFILADISKVDFPEDYPFPDYIKSRTRDFRFAWWLAHEFGVVTIPPSDFYGEENQKLGEQFIRFAFCKEADILNEAGERIKGLAKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6L4</accession>
    <name>I4Y6L4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960404.1">
        <property type="nucleotide sequence ID" value="XM_006960342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6L4"/>
    <dbReference type="FunCoup" id="I4Y6L4">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6L4"/>
    <dbReference type="GeneID" id="18474517"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61408"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6L4"/>
    <dbReference type="OMA" id="VMIINLR"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="177" mass="19984" checksum="7164FF539F55A46C" modified="2012-09-05" version="1">MEVLNARVGHLSNFEVFEIIKELGSSTVDNLRFTQTEAVKYLSNDNLSTTKQNETGITNLLQSLEQFQTLTRAEKLMIVNLSPKSVVELYVIIEELEDRLSEEDIEAILSLVSTNLGETTNLQNNNNDDNGPTDEPLFVDEDEQENAKYEQEIAEQEELENADVGEEEARGIDEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6M1</accession>
    <name>I4Y6M1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_58609</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960276.1">
        <property type="nucleotide sequence ID" value="XM_006960214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6M1"/>
    <dbReference type="STRING" id="671144.I4Y6M1"/>
    <dbReference type="GeneID" id="18473038"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58609"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352034_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6M1"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="428"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="516"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="799" mass="89277" checksum="DBC2156A6C48CEF8" modified="2012-09-05" version="1">MTILKCRLDSIKWNGTSGLQIACQKTHDNIRKAAISLLEGKIVAFPTETVYGLGANAFNEKAVNSIFKAKGRPNDNPLIVHVSSFKMFEKYFSQPMPSSYDILTKHLWPGPLTILVNSPETLPGETTAHLTTVGVRMPSHPVARALIEISGTPLAAPSANSSGKPSPTTADHVFDDTFQRNEAREVMDFILDGGSSDIGLESTVIDGISEPGKIKILRPGGVTVEAIANIVGIENVIYERNTVVSDDFKPNTPGMKYKHYSPNAKVMLILPSTAHSKKERSDPTEIIKKLPPNQRIGCMTLSGSDLTKKLIKTDDDNLTSQKSSIRDDLEMIPYMLGSSRDTATIARNIFGGLHALDKIKVDYIIIEGVSEVNEGLAIMNRLYKAAGNIDNSHRNSFTLHDVAVALKIEVPIKNSPIFRPESLDIMDSNQLKNELINIEKQNLHYQSELSLSTAISYELYQQNEKLNKDYADLNTEIEAFKSLIQSHLKIETSDLNMQRRELSFALKQEVENANSMAWIEAQASELKLELNAVKQQSSREILQTRKQLRDVILERDNLKRDLKFSKERFDALQSQSSQLMLARKSWSVFRQEWRRNDEQNTFNTSNIQFPQVKNDSPLAERRKSLSGSEVVSSSGLTPKVLKSTNIPLSEIKYKPSSKIGFPNASSNSTLFNKRIKHKKSFSDSAFIMNSDQRRILTLENELEIAKFANMRTQAVFTSIENFTTFIFNIPSSLTLSQVFLAIYLSVTSIFLNTAIRGLAKVLLYAYFSLVLTLLIIKSQLTITSSNKSSLKAILSRNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R2</accession>
    <name>I4Y6R2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960316.1">
        <property type="nucleotide sequence ID" value="XM_006960254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R2"/>
    <dbReference type="GeneID" id="18473041"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58632"/>
    <dbReference type="HOGENOM" id="CLU_683701_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6R2"/>
    <dbReference type="OrthoDB" id="3363891at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="403" mass="45742" checksum="3CD9AA558BA88FBB" modified="2012-09-05" version="1">MTARRWDGEIVPALRKRLESESSELTKRMSAHNEGANGPLKQYSQMSTLSPVNAIPTPKAKSSRSKDNFAFVEPLPASLLHEKMPDGTASDDSTEEDTFIESTNARIKFPKRNRQPNTSNVLTKSNIPRRVRPRANTNVSMMHNRHRSNDEEMLEIAKLGHTGYMKESEDVYGGYEQENAQEVVDTEITRPSTSSAAKNIPQSTNRSQGGRSYSSFGMYDNQNKPKKKVKRRVPTKGRQSEPYRPPTPETDVDLEPWSVPPSTSTNLPPGKSWDDVVVPTLARKMEMEKHREDEIWSSTGSLNKKPDNRRSKNEIELDTIHDYRASQLSDASMQPEEIITTPQSIHNTLQPDYSLRPVSQQTFDDRSNILRSPVQQVPPAQRHYKEEQRPAKKKKSAKCCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R6</accession>
    <name>I4Y6R6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">WALSEDRAFT_48773</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960320.1">
        <property type="nucleotide sequence ID" value="XM_006960258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R6"/>
    <dbReference type="STRING" id="671144.I4Y6R6"/>
    <dbReference type="GeneID" id="18472466"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48773"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6R6"/>
    <dbReference type="OMA" id="ISGYQDP"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="23">
        <location>
            <begin position="173"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EIM19658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="528" mass="57869" checksum="93953C3579E03BCC" modified="2012-09-05" version="1">MFRATGNITKSFNRASFRRISTASRSPSIRYGLICSAGLAFTVAVTTSKLSLESQQVPEEALSEANPAKARYVAFDEVQKHTTPESCWVIIEGQVYDVTDFLEAHPGGAKVILRNSGKDATTLYAPIHPKGTIENNLPPECHLGAVDPTTLPDIQEEESDEQRRVRTARENIPPLGAMVSLEDFEKLATDILPNTAYAYYSSAGDDEDTLRENINAWKKYWFRPRVLNDITKIDLSTTIMGIKSALPIFISPAAMARLGHPLGEINLTKGAAQTGIIQGISSNASCTLEEMCEARDAGQPLIFQLYLNWDRKKSEEIVRKVEELKINGIMFTVDAPVPGKRERDLRAKGDFDDDEGGTKGVAQAISGYQAADLSWKDVDWLKSITDLPLIIKGVQSVEDAKLAAESGVKGIVLSNHGGRQLNFAPASIDVLREIREEAPEVFEKLEVYVDGGVRRGTDVLKALCLGATAVGLGRPFLYAQSAYGEQGVVRAVQILEEELATGLRLLGVTDVSQLNPSMLRYIDQRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y0</accession>
    <name>I4Y6Y0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960230.1">
        <property type="nucleotide sequence ID" value="XM_006960168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y0"/>
    <dbReference type="GeneID" id="18475727"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70390"/>
    <dbReference type="HOGENOM" id="CLU_1556475_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Y0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19343" checksum="0C722BDDEB06B574" modified="2012-09-05" version="1">MPNSIITRAQTISTSWKKQFSRIFKHSSKASTPDTRVSVLIPIPSEVPQIEAKSDSQSEIQSEDNFSFEKASISTSTTRSSTKHSIVEGLDDTYVYSVSIIVDYDETRRVSTSLKSSLRGRGSFSSNNKSVRFTEIDEECLIDYSEDMDDDFDEDILDLVLFGEDGTLEGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y760</accession>
    <name>I4Y760_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_33799</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960136.1">
        <property type="nucleotide sequence ID" value="XM_006960074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y760"/>
    <dbReference type="FunCoup" id="I4Y760">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y760"/>
    <dbReference type="GeneID" id="18471749"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33799"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y760"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="488" mass="53753" checksum="22CBAB02CC4A090A" modified="2012-09-05" version="1">MLNRVQRSVLRSARGFASVAEPPVRGYGGLRDQDRIFTNLYDRHDFGLKGAMSRGDWHKTKEIVLKGDQYLIQTVKDSGLRGRGGAGFPSGLKWSFMNKPGWEKDPRPRYLVVNADEGEPGTCKDREIMRGDPHKLIEGCLVAGRAMNATAAYIYIRGEFYHEAVRLQQAIDEAYKAGLIGDDACGSGYKFDVYIHRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVVPTIVRRGPAWFDAFGRDRNSGTKLFAISGHVNNPCVVEEEMSIPLKELIEKHCGGVRGGWENLKGIVPGGSSVPVIPRDVCTDVLMDFDSLKDAQTSLGTGAIIVMDQSTDMIKAISRFAKFYKHESCGQCTPCREGTTWMYNMMNRFEKGQASNREIDMIIELSKQIEGHTICALGDAAAWPIQGLVRHFRPEMEQRIREFQLENGVVMYGGKLLKDHNPDIAIPDNRGASIPPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D1</accession>
    <name>I4Y7D1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2 6">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_48307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2 6"/>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960015.1">
        <property type="nucleotide sequence ID" value="XM_006959953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D1"/>
    <dbReference type="FunCoup" id="I4Y7D1">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7D1"/>
    <dbReference type="GeneID" id="18472448"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48307"/>
    <dbReference type="HOGENOM" id="CLU_031468_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7D1"/>
    <dbReference type="OMA" id="VEWWTET"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="33133" checksum="2304C5E96112F275" modified="2012-09-05" version="1">MITVLGLGSIGSLLSCKLRLNSCRLNVISRLSRNAEINYKEYNGLEHTIKGFEVHTAESIPPIQQLIIATKASDALPALESVRDKLNEDSSVLFLQNGLGYLNHSKLKTFNQQLLISNTNIAATLVNGKLIESSNGGTFNVTTYTPSQALTKNSEGLLHTLASLDGIDVKMVDNKDFLNTAHLKLVANCSINALGSIHNCKNGDVYQLNKDLVEGVINEASTVLCLDEKSTRDYVLNVLQSTKDNYNSTHRDIYQRGKRASETEIEYINGHILREADLRGINTPYNRYIYDDFMCKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G1</accession>
    <name>I4Y7G1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960044.1">
        <property type="nucleotide sequence ID" value="XM_006959982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G1"/>
    <dbReference type="STRING" id="671144.I4Y7G1"/>
    <dbReference type="GeneID" id="18474413"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61244"/>
    <dbReference type="eggNOG" id="ENOG502S178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7G1"/>
    <dbReference type="OMA" id="MFKANSR"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="26265" checksum="78F5550A2858B220" modified="2012-09-05" version="1">MSKIVKKVVTDITGKYVFSKVITGPRNPLYQEFTDDEGHVQSKKREVPVGLSKKDQAVLKKIRKRAYYLDKGFTICGFRFGYTFIFGLIPGFGDVLDALLNYFLVLRLAEKNLDLPSGIINHAWFNNLASLGFGLVPLAGDLVLAAWKANSRNAQMFEEYLIKRAEFYINLPEESKELAAQLDIQGDVLYDQENAEFPKKLFKAAKGIKAGHGLKKSEGVKLREEIKQKLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7N1</accession>
    <name>I4Y7N1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959904.1">
        <property type="nucleotide sequence ID" value="XM_006959842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7N1"/>
    <dbReference type="FunCoup" id="I4Y7N1">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7N1"/>
    <dbReference type="GeneID" id="18471720"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33619"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y7N1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="244" mass="27209" checksum="826FFA9ED29C41F9" modified="2012-09-05" version="1">MSAVNRQLSKSRKIVQDGVFQAELIEFFTRELSEEGFSGCEVRVTHARTEIIIRATHTQEVLGEKGRRIRELTALVQKRFKFPENSLELYAEKVQNRGLSAVAQCESLRYKLLGGLAVRRACYGVVRFIMESGAKGCEVVVSGKLRAARAKAMKFTDGFMIHSGQPVRDFVDFAVRHVLLKQGVLGLKVKIMRPHDPEGRAGFPKPLPDSVVIVEPKEEQPIQVVSENKAKPNVEAAPAQQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7U3</accession>
    <name>I4Y7U3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoaE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_70194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959964.1">
        <property type="nucleotide sequence ID" value="XM_006959902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7U3"/>
    <dbReference type="FunCoup" id="I4Y7U3">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7U3"/>
    <dbReference type="GeneID" id="18475699"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70194"/>
    <dbReference type="eggNOG" id="KOG3220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7U3"/>
    <dbReference type="OMA" id="RWEMYRA"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27717" checksum="B5A1A94C1FF6EBC0" modified="2012-09-05" version="1">MLVVGLTGGISTGKSTVSQRLQNEHKIKVIDMDLVARQVVEPGTPALHKIVERYGERVLKWDPHTKKNVLDRPALGRILFADKSEKKWIEGVLHPVILKKTAWEVLKAYITLTRVVVLDVPLLFEASLHKYIGISTLVYCPPSVQLERLMIRDGITHEEAANKVKSQIPIDEKLQLSDEIIYNDKTKQDTFTRIDEVVEGWYRRTSWWYIAQWVCPPLAAIQAAWIIYSRRQRVVKVNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Y2</accession>
    <name>I4Y7Y2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCAS3 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959795.1">
        <property type="nucleotide sequence ID" value="XM_006959733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Y2"/>
    <dbReference type="STRING" id="671144.I4Y7Y2"/>
    <dbReference type="GeneID" id="18474335"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61106"/>
    <dbReference type="eggNOG" id="KOG2109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384128_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Y2"/>
    <dbReference type="OMA" id="HMRENDS"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="2">
        <location>
            <begin position="249"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="651" mass="72371" checksum="039056E106A17372" modified="2012-09-05" version="1">MKSQLRANEQNKEFSHLLLQINDDDSGDRDWGFRVYGVQKASRVLLQDSSTNISLGVLKDYQSLLICTTAEPETIRELNIPSEETIKSVHFNSAITNISTTENYISAATETEIHILDHDLQTLHSLESPCPRISSIANRYLAYLYTSQPPQSSSGILASKNLKYSDRPSYTTAEIASHVASYLEEGYKQGHRTFDVIQNYYNNTFSKSVPLTSPSIEASSPPLMSVSPASLAEQNGLFTRKPSVVRVLDIVSGRTVALFTASIANLSAISLSPSGRSILVADINAHTFHVYELRPRPLFDNTAEYDSVWHRYALRRGYTTARVTSIAWSKDERWCAVTTEKGTTHIYPLNPNTGGAITNSHVTGEPIKFGSKYTSLSTTLSSVIKIKSEILEENHGLPRSVTFSFADGERSKLIGYTHDNDFKQLIKWDYKLTWKEFEKEDGSKHSHIDACLDSTSETGENTSGSQPMKKATSSASKGSSVHPSQIAKGEIETFDISSLRSIFTSRQFEFRKIATTDMLNNDVTSVLMKSQIYKVRPEVKVNKLNDDTTDNTDNLDLSSIQHIIPALPNGIEHKASLSLPDQHTLKRILKGSYKRISSTFGSPGSQIDDAHDDDHNSNENDVGIYKEAKDASEEADKFVVGLVDDDEEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y865</accession>
    <name>I4Y865_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_48140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959878.1">
        <property type="nucleotide sequence ID" value="XM_006959816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y865"/>
    <dbReference type="STRING" id="671144.I4Y865"/>
    <dbReference type="GeneID" id="18472443"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48140"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394938_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y865"/>
    <dbReference type="OMA" id="CESWLPL"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="40"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="253"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="391"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="625"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="690" mass="78170" checksum="761E74E825C85685" modified="2012-09-05" version="1">MSVVDRLSHQLNKSKECTYKDSNDNTLINSTNFKKNFLQKYFILTENGKPVFNSDEFHDSYRLSNKQFNLALKSKASLNSLKTASINSLRMGNLNELRHNDDENEEEFDYTSLIGVLTLVHNLINLENDEIKYIKSNNDLTIHFNKFDHLIYVYISNLKESNKIISQRLGLLHQQLLSIIPKYHIDNIFRTKPNYDLRQLVEGSEGLLKSFIIKLESNFNYNLMGIQPFKMDLKFRNLIGSMLLPPKHLKSHHLYTILFAYGKVVTIVRPKKHSIHPTDLIIVLNTVTSSPSLRNCQSWLPISLPKFTSKGFLNAYIAFEGPSAQLKGELGLSNQPEIGVIHISGNPESFEDISDWWDETKKKLKENDVFDHIYKSANESAYSCGDVAVPGVRHFVFKNKANVQITCPTYDSPYAEDMHSRQRLLNSYDELYNRVRSTSATSGIGIPSSKSSDSLRSSAKDKDTIAESTSRSSVIGDRTSVIGDRSSTIDGAESVIDNNGTNADGDDNEDVTTSESARVNDLADQNTNTSEQTVQPEVADQQDERRVNDKDDTKQTDNQHDKNDTTVITKRNDKTLSKQLYQATITTPTNLLKTTTSMMGGLLTVPSIPQFGQRSTQSTRSTPQHVRQRSSYYIKNEYEGVLVWSTRIFELYIALPASMPHRAAINSAQSLVKWIRREEQSLFLGNTPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A7</accession>
    <name>I4Y8A7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959687.1">
        <property type="nucleotide sequence ID" value="XM_006959625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A7"/>
    <dbReference type="STRING" id="671144.I4Y8A7"/>
    <dbReference type="GeneID" id="18474308"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61051"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330154_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8A7"/>
    <dbReference type="OMA" id="PIQSCFQ"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="869" mass="97431" checksum="1478A3855F738A26" modified="2012-09-05" version="1">MSHLYVDSIPDMKQPTPRKRQVQACSECRRRKIKCDRVFPCRPCKSRGDDAICREVEKHDESTTGCASSTSLELLTNRVLHLEAALRSMHQRLPQDLQAGLMPASLSLAHERATSSNPVKPEGPSRRGRPPKKKLAPQNTQEQEKETTGSAQSRPPLSSAVSNDSDEEEAAMILEDFAFGRREKPSFPNDRLKLNSSASSPVDSPQTSYNYPGNVPSASTSTLPRIGPLKASNSFTPPDFKLMRCETSAEDYLKSILAVLPDIKKGKALVKLYVTKVDFFHKAMHVPTFLNDLDIFFRQLNSNSTKEHDEIPPAFTGLYLIVICVALHFADTEEAIAAGFTQEEHKTLPSLYFAASRACLWASDYLENHNLKNLQTIILMGLYLNNTNGSSTHYSLLGAAIKIAQNLGLSRLGGENHALDDVKNSRKSQRSGMWASVVTREVGRRIWWNLVMLDWFLAGPHNYNYSIHPSQNKCCLPSNIDDDDLIDGQPLVAKPMSVYTSMTYQLTRLRSLEHVRAIVDEYNENGHLSLEFTLIQDKKCKDLINDLPEFYKMNYDVKQLGLSPERMQILQWERTLINLSTHTRLVKLHRPILSKGYRNKNYLQSRITCITAARECLAVLRHGDSVGFLERWWICVYYAFASAIVIFIDLIHDDPMSSDAFDKREEIKSALNMLKDASGFSSGADSSAALLEGLLAEEIRQKPDLKRKFGADDRDRGSRQRSGDLSILVKKLLDEGQAAKISSPGSSHHSTPQYQSEQPTNLATYAVANDQKVENGKNSQHPGFTDDLLKRVFEEGDAGLFGLPLNTNYSQQPFNVNMSDLNTNYMPQTTQANDMFTGGDMQFNIDQLFDAGDNNNTWNVLGGNSLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X0</accession>
    <name>I4Y8X0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_20425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959438.1">
        <property type="nucleotide sequence ID" value="XM_006959376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X0"/>
    <dbReference type="FunCoup" id="I4Y8X0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8X0"/>
    <dbReference type="GeneID" id="18470840"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20425"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8X0"/>
    <dbReference type="OMA" id="YGICTTA"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16581" checksum="7568B2E931A49809" modified="2012-09-05" version="1">MTYTNEIIDRYDNIASIPTTLTGFFGGASYFSTLDPGQIIFGIEAVWVYSFASVSCGALGWLTGPTLGTAVWKFLHKAKLPEYEIKERVFYHHIMKNRVDPARQSVQNPVPDYYGENVYSLQTYRQWLRDQATYNRKAYLSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y910</accession>
    <name>I4Y910_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959478.1">
        <property type="nucleotide sequence ID" value="XM_006959416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y910"/>
    <dbReference type="FunCoup" id="I4Y910">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y910"/>
    <dbReference type="GeneID" id="18474256"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60926"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y910"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="225" mass="25773" checksum="2BA40958B8054F24" modified="2012-09-05" version="1">MSKPLDDEEVKQELNKMVSFIKQEAEEKARELRVKADEEYENEKAKIVAQEQHHLNAVYDKKFKQALVARKIAQSTQTNKARLRVLSSREEHLNSLFEEVKNKVDKLSESDDYADILRRLIVQSMLKLMEGQVIIQARPKDEKVIESILDDAKNEFKEATGKDVDAQIQTSLEDASAGGVKLNGFGGRISIDNTIEARLSLLEDRMLPEIRMDLFGQNPNRKFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y911</accession>
    <name>I4Y911_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959479.1">
        <property type="nucleotide sequence ID" value="XM_006959417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y911"/>
    <dbReference type="STRING" id="671144.I4Y911"/>
    <dbReference type="GeneID" id="18475649"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69819"/>
    <dbReference type="eggNOG" id="ENOG502SA4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761197_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y911"/>
    <dbReference type="OMA" id="VKHANPI"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="40423" checksum="B8A710E0C1F64BE5" modified="2012-09-05" version="1">MTSPGLPKDFNELLDKSEIPSPKWQQITRDDRPITIARLKLPHPREKHTFILRRYDCNGISFGSLFKAAYPYATDEEEKIESGFVKKNYDVTLVPTEEYQERKLAKLAGFWIPIAIAEELGQRYAMAEYVDALAKADTPDLTDFKKRSSNRQTSEDIKSSPAKAQASLESPAKSASKIPTPTKNPAPRRSARHQSRSPSPSPLTHNLTPGKKKAKKAPKEAVIEESVEETIVVDKKESPLKKALNDDQVLADIERAKDLVDDIKQSKNLSQSSPVKVVKEEVLETIQPSVSTESLEGEGKRKRELEDETGNEIKVVSFGQNPPANPEEIQQRPVVQRRGVAAAVGAFALGVGFAASNILPRFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y953</accession>
    <name>I4Y953_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_20434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959521.1">
        <property type="nucleotide sequence ID" value="XM_006959459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y953"/>
    <dbReference type="STRING" id="671144.I4Y953"/>
    <dbReference type="GeneID" id="18470841"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20434"/>
    <dbReference type="HOGENOM" id="CLU_152712_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y953"/>
    <dbReference type="OMA" id="CDITNSH"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="13892" checksum="E983AA0FBDC1191C" modified="2012-09-05" version="1">MPSWINAEIPPDSLSRLLEALLAKTIPITSHEKTQVGVASSMKEAFARHAYIILHTYAQGNTSSASFYPANIRVGLQPGLFALCECVDTHREREFMLSGLTDEGARSVIKTLWKEYDSQKYVGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A1</accession>
    <name>I4Y9A1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959337.1">
        <property type="nucleotide sequence ID" value="XM_006959275.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y9A1">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9A1"/>
    <dbReference type="GeneID" id="18474207"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60853"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9A1"/>
    <dbReference type="OMA" id="REFLMPI"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1523"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1636"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1337"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1486"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1731"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1382"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1428"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1451"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1731"/>
            <end position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1762" mass="196806" checksum="7D82BD07C7A5CC39" modified="2012-09-05" version="1">MAVSREAHKRGFSLTHQRVVLDLDFGGLFRGFTELTITPISDALKTVNIHSRQATIHRVLVTPPNPTATPIPTDFTHRDPQSHINLAENEGKDGKVDVHRHPELKRKVYSALAQGDEGELSISLPPGCIVRGLGDNVQPEIPPSSADKDKEDPKEQKEQKEQKETTQNTQDFAPITIFVEFSITQPFEGLQVVKPTETSPYRIPHIYTSPTCPDAARCWVPCIDSLWERCTWELEFITPRFLSAVGEDGVEGEQDDPVVVVSSGDLIEQVAHPSISSKTIFHFAQSLPTSVQHIAFAAGPFTILPIPHTSATTQSTLLHAFGPPGTAKELAASVAIIPRALQFYSAEHGTYPFSSFKVVFVHDPPVDVSVSSTVVIMSMDLLHPASAIEQTLDTRQKLSHALATQWSGINIMPRSWSDMWLVQGLASYISNLFLKKSMGNNEYFFRMKKDMDRLAMNDTGQLPPLCVPNALEPANDNDAPFLLLKAPLVLHILDRKLSKSGTAHGLSRVLPKIFLGALSGDVIISTNGFLRTCRKVAGVDLRQFADQWIFGSGTPRFTIGANFNRKKMCVEMTVKQESPAYDAHTPNTPEMHYNRPTQIFEGQMTVRIHEADGTPYEHVLDIKDANKRFDVPFNTKYKRVRRNTKRYQARQAAAAAAAQGDEEAAEAIGMIDLGFQLNDWEQESERDRWKVEDWTEEDEAAMSQATYEWIRVDADFEWISMITFEQPDFMWVSQLQRDRDVVAQLEAVHALKSIPSKLVSTQLTRTVLVTNYFFRIRMEAAMVLHTCATPELDYIGMFHLFKIFQSRYCYPPPQEIMDPFGFKCIPLANNFDDLSEYFVRKAVIVSLTSIRDQSSRSMLNIREFLVDQLRYNDNSSNRYSDSYYLSGIISCLAIALVPTVQHEASVLQQDEDPDANDHPFGPHVRRQAIEEVERYRTMDRLVPSYQNVISVATLEFNVKLMIAGIIPNNAPLFIPYTREGNYPPLRIVAFDCLLLLGALRHRPIIQYFSTILGYDESRVVRRSLAQSMIESLIVLMATGDLAAIQKKEPQFIEEDAKLSEIKEKDSGKSELDRQLKGLRKDIGKLASLRMGIMTALLSSQVDYQVRWTLLQLCDVLYKGNTEPLPKVKFKLPAPAPAPAPPQPPASTEQTPTMPVKIKLKAPTIPSATPASATPPPVMDTKSPEPTLPETNGNANGYTAPSGSGLNISLKKKRDKAVPQAQRGGMSSQDVSACRAIHKRIQGHKTAGWFLYPVDPVRDGAPDYFTIIKEPMDIGTMSAKLDSGHYASRFDYENDFKLIIKNATTYNGPSSPVHKTALELDAFFDKQWQRVANTLNAAAGRRPTAQANDAMPSPPSKVPDASEVTQPPPAQPRLSLKIKPPKPVKDTDKDMESNGNDNLDRPVEASNPPADPAVITQPEPPVAVEESSALPSEPSTQEVKTESALPDADVSATVSQPVEEQQPQMDVTTAQSNHEDILNDELLALSDNKPTTTSMPPPPPKMPQTQSDGTLDYRKAKILLRKLTGMPEAAIFLQPVDPILHGCPTYLDEIKRPMDFSTISKNMDQKKYVTNDEFINDVEQIFKNCRQFNGTSETSTLTAQTCDPVEKAFKREWRSIMLPKIPHNEKRSLVSTMKGWYKSEHAFWFLQPVDPVALGIPHYNDIIPQENMRDLSLIQSKLEKDQYPSVDAFEADIKLMTYNAILFNGPDSPVSISAKILEKMVANSLKEFKNKFNSLSPQPSTQTHKRASSTTSESRSNKKSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9E3</accession>
    <name>I4Y9E3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_69736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959375.1">
        <property type="nucleotide sequence ID" value="XM_006959313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9E3"/>
    <dbReference type="GeneID" id="18475634"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69736"/>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y9E3"/>
    <dbReference type="OMA" id="PISDQCK"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013985104" description="Hydrophobin" evidence="5">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="108" mass="11190" checksum="C952B9F30A7F15CE" modified="2012-09-05" version="1">MQFSTIALTATAFFSASLAAKLEMRAGDCSTENVKCCDQVKDASSVDTATLELLGIDELAGQVGLECTQIAALVGVPIQDQCKTTAACCDQTTQNGLANLNCVPISVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H7</accession>
    <name>I4Y9H7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31552</name>
        <name evidence="2" type="ORF">WALSEDRAFT_33240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="2">CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956882.1">
        <property type="nucleotide sequence ID" value="XM_006956820.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959406.1">
        <property type="nucleotide sequence ID" value="XM_006959344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H7"/>
    <dbReference type="GeneID" id="18471327"/>
    <dbReference type="GeneID" id="18471642"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31552"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33240"/>
    <dbReference type="HOGENOM" id="CLU_2177209_0_0_1"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="110" mass="12482" checksum="673E8D1DB741A00F" modified="2012-09-05" version="1" fragment="single">MQVEREFIPPHIPTPHTVFIHSDSLAVLSAIVQLQTTKTGQYLIKQVLDKIERIKRMKGREGTIVQLNWIPGHTGIYGNELADRTANEGRTKCNHYTNIDFTLSTSYSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Q8</accession>
    <name>I4Y9Q8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959233.1">
        <property type="nucleotide sequence ID" value="XM_006959171.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y9Q8">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Q8"/>
    <dbReference type="GeneID" id="18471625"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33141"/>
    <dbReference type="eggNOG" id="KOG1517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001136_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y9Q8"/>
    <dbReference type="OMA" id="TEVCTND"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="75"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1535" mass="171528" checksum="3E99A7A0F0A28C5A" modified="2012-09-05" version="1">MSASGTENDVETINSNNFNDLQLNGPRHGFADPFTQQDISDPYPLLPYFVSNRHFTGGNPSPDEPPEPDWRLRERLKTITCAIVLCLNLGVDPPDVVKTEPCAVLETWVDPTNMPPPKALETIGRNLQQRFESLSQRTRVKQYLDPSVEEMRKLCASLRRNAKEERVAFYYNGHGVPKPTASGEIWVFNRNYTQYIPLSIFDLQSFIGSPGIYIWDCSSAGNILNSFVKFGERRDHDIKTAYESTKQMANANNMAHAMPTSPYPASIDGRPDTPPVFFAPLGDSIHMAACSPDESLPMTPELPADLFTSCLSSPIEMAVRFFLLQDPLSKKPDLDLCLKIPGELKLRKSPLGELNWIFTAVTDTIAWTTFPRETFKRLFRQDLMVAALFRNYLLAERIMKTYRCTPMSHPVLPPTYNHPLWHSWDLAVDGCLSQLPALLGQEKLTKEAQYNTQAANELKNTTLLHYQQSSFFQDQLTAFEVWLSRGLSSSSSASTAPGSMPATWDPVKRRDYNPPRKPPDQLPIVLQVLLSQAHRLRALVLLSHFLDLGPWAVNLTLSIGIFPYVQKLLLSPVPELKPLLIYIWTRICAVDRSCQNDLLKDNGFAYFARVLSPFQEDGGLQISNVSEHRAMCAFILSLFCRDFKPGQMACFNSGVFEMVLVHLNDEDYLLRQWCALMLGQLWDGNDEGRALALREGATDRLCSMLNDISPEVRSAVMFALGTFMGASGSVWKDVNKQQPGEVPRLGGGGTGSLPGISSMEHFMFEVQLATAGLAAKEDASPMVRKELVIFWSAFVREWQGWFCVAAYAYYVSEKRDESRVTGNPYKPSLTVVKEAIYEHQGEKAGDKLLDDFAALYMALLDMTLDPYPEVGSLACTVVDFIHALLIESPLSDSEDSALPHIPPVRPDLGSDSEDKPIGGTKKSKKGPPLPRTFTEPNFAKGKNLKNLKGSSPLKSSGSFAAALNKLTSLPSFTTLTSMNKGQEEPEEDHPSPHFNHALYHSPYVPQQITKITPEIAPNSPSVDMSQSGQNADTPPRTPSPEFIDHGNNGNNVQEQNGDHGVYDDATMNVFDAVTTLLDEDDYRLRRRKERTMNSGQFHSTTLAPNNADVPIMPFRKELQAQMGIVLPLKSRLFDWCCEYFTEPQMRNPEAEEPGSEKYNEQMWRRQRNEKVVIDTQAQAEVASRSEWRENIINIQEHYFPVKLNFHQFEPQLITADPHDAISIWDWKEGVRLNRFGNGNPWGSNITTVKLINEDDQALLLTASAEGMVRVFRNYSTPGGAELATSFRANSEMVPSRYPSGLVADWQQATGHLLVGGDSRVVRCWDSQRELFHSDIQTTAQSCLTAITSDQDMGNIVIAGFGDGTVRVYDRREDSRNSCVAHYREHLSWVQNIHLQRGGNRELVSGSIDGDIRLWDIRAQGSISQVDAHREGMSCIDMHEHASVLATSSMPEFNSSGIRTQTVKLWKVDSEGILPRGRTISSRPLAPPAKALPFNPSVSSLAFHPNEMLVGMGSADGQISIVACNEAMSTHEDNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9R4</accession>
    <name>I4Y9R4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959239.1">
        <property type="nucleotide sequence ID" value="XM_006959177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9R4"/>
    <dbReference type="STRING" id="671144.I4Y9R4"/>
    <dbReference type="GeneID" id="18474987"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65126"/>
    <dbReference type="eggNOG" id="ENOG502S9MF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467084_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9R4"/>
    <dbReference type="OMA" id="AHEHEQG"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="469"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="476"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="584" mass="65236" checksum="6E71DAD83D7E4FCC" modified="2012-09-05" version="1">MTNMDTPPEHRDQIEQLKGADILDINDLISIRDQLNNDSLDIHKDDLLAISKKLLTHSFEIQKLDLNKKSLITKNNIGKIELESLKRQAEALSWKLERSRWDARLTRWEAHDEVEPQGTSILHQDIETENRMLVGDKRVLKTKLEEALKRSNRLENELRQIRATLITKAHPGIEAWKEAAWHDGDATRSDQYGMGDARAEHLLLASKRLNNLIRRSQNPDSYQSLQPKQISRRKAMHSASSSTPKQMHQNGLENLINAATSVFDQPTRSSSRSPLKLQTRTRSPSPQVSPKRRKLPSRATAEQHEYVTGGDNRNEDPYLHYNASPVMKQQQQKSSENPIQGSALDFLADHAVEQSQNEMGTPNSSYALPPKLNALERDRDHINELGPPLKLRGSSPQTPSSPALESPSKPSRFTPSSAANSPRVIKAETTTPQIPPFVVQQPQAPHPSATFNVPPAGFTSTRPSGPSANSRAPYTKWTGAEDALLAKAVSIHGQKWDAVSKMVGTRSYHQVRQRYLRKSGQNPTPKAGHHNLRNSNTDRDDDSTDSPPISASSTPQPPSHQARTTTRGNSPSRSSSSRREVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W8</accession>
    <name>I4Y9W8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006959225.1"/>
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    <dbReference type="FunCoup" id="I4Y9W8">
        <property type="interactions" value="873"/>
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    <dbReference type="STRING" id="671144.I4Y9W8"/>
    <dbReference type="GeneID" id="18474195"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60833"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="InParanoid" id="I4Y9W8"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="370" mass="40959" checksum="1E3805F8D408CD91" modified="2012-09-05" version="1">MAKRISENSNQLISKRVKSSDLEDKLGLNSPNTQQLALSQKKDSDNQLIRSVQRTSKLAAPIIKLEGCHTDEITAVKFDLTGNFLVAVSTDRSISLWKTYTNENFGYIPFAHKQAITSLALSRTSPSNPAIITASADNTIAVWDSFSGKLIRRLREHTDIVNAISLSKNPSHELLASAGDDNKICIWDYSESKHPLHVINWNAPVISIEWSDDESTIFIGGLDNEIHAYDLKTHSKLYSLRGHSDTVTFLRLSPTGQYLLSCSNDSTVRIWDVRPFTNDPSRIHRVLHGTVSSFEGVYTQPAWTQDAARVAVGSADRTVTVWDVETGNILYKLPGHTGTVNAVDIHPSEPIIVSSGKDAKMYLGELMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9X0</accession>
    <name>I4Y9X0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_47258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959288.1">
        <property type="nucleotide sequence ID" value="XM_006959226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9X0"/>
    <dbReference type="STRING" id="671144.I4Y9X0"/>
    <dbReference type="GeneID" id="18472412"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47258"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y9X0"/>
    <dbReference type="OMA" id="YQIEGHG"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="440" mass="50501" checksum="D4F283E80BB7D9B9" modified="2012-09-05" version="1">MSYILQCGGRGPSIWDKFFADGKHSADGATGEPASDSYHRYAEDIALLKSYGATAYRFSISWPRVIPRGGKNSPVNHEGLAYYNRLINEIIGQGLTPFVTIYHWDAPQALEDKYGSWLSEQIVDDYERYARVLFENFGDRVKHWITINEPLTISAEAYIVGIFAPGHTDLTESYKVAKNQIMAHARAYHVYKNEFASHQHGEIGITLNGNWFEPADNSPKAREAAQVMMDFQWGLYADPIYKNGDYPRSLHERNSEYLSYFTPEESKYIAHSADFMGMNAYTSSVAYGNATDNPSTGYTYTSFWFPNGTAVGGESNESWLWDTPWGFEKLLVYLWDNYHYPIYITENGFSAKDENSKPLNELVQDYDRVNYHDGYLNAMLRAIHRGADIRSYFAWAITDNLEWASGYSSRFGITHVDFDTQVRTPKLTSQFLKEWFKWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA57</accession>
    <name>I4YA57_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959111.1">
        <property type="nucleotide sequence ID" value="XM_006959049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA57"/>
    <dbReference type="STRING" id="671144.I4YA57"/>
    <dbReference type="GeneID" id="18474130"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60737"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="I4YA57"/>
    <dbReference type="OMA" id="INHPARW"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="372" mass="39329" checksum="8B677D9808BCE832" modified="2012-09-05" version="1">MSNTTNTIAVLYGAKDLRIENRPARELGEFDAQVDVKATGLCGSDLHYYRHGKNGDFVIREPLAMGHEAAGIVTSVGTGVTNLNPGDRVAIEAGIYCSSCALCKSGRYNLCPELRFASSAKTYPHLDGTLQTRFTHPARLLHKMPDGVSFEQASLVEPLSVVLHGSRRSGVRAGHSVLIYGAGAVGLLAASVVKAQGATSVTVVDIDSNRLNFAKENSFADNTVLLPMGPRPTTPAEGLEASKKTAETILSESASKGNDVVFECTGVETCMQAAIHTAKPGGKVVYIGMGTPNATLPIAAAAFREVDLVGVFRYSNTYDDALGMFAAKKLATADKLVTHKYSLADSKAAFEALSNGKDAEGRPAIKIMIGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC8</accession>
    <name>I4YAC8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">WALSEDRAFT_39047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958918.1">
        <property type="nucleotide sequence ID" value="XM_006958856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC8"/>
    <dbReference type="FunCoup" id="I4YAC8">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAC8"/>
    <dbReference type="GeneID" id="18472096"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39047"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="InParanoid" id="I4YAC8"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="137"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="367"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="501" mass="55309" checksum="5A4B55EA8FA0E569" modified="2012-09-05" version="1">MSSERLVEIPALNEFRLELDIKDELSIKLINGRAELNGFELSLDKWTTLKDELKCSIYTWIGCTLEIKGQSLVEYISNETPLISYLNLHLAFEQQRIKARTTNKEYTPSPEKPNERLPGYVNSIDQSSSGYRVMVIGQEDSGKSTLSKTLLNYTARTGKGWTPILVNLDPSDGGPLPPGTISATAYSTSTQTTSPVNAFGSSSTSGASLDNSSALIPQALPYAHASPARNSKVYKSIVEAIARRLDMRLERDSKGKASGVFIDTPAAFSLPNIGSEDKNNKYELIKHALHVFRVDVLLVIGHEKLYIEMQRLQKTLDPKIGQNLKVLKVPKSGGAVETDDAYRSRVQAGQIKSFFYGNLSNPSDEQLSPQSMTIKIDNLKVFRITEDKVAPTSALPIGASRVLENTQLERVNFESSSQLLTLVHSLLYLVKWPDVNDVLNKHAKEYEGDLASKDLIRADLVGFLIVTAIDSVKRTITVLAPSPGRLPSLTAVYGSFEWQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAI4</accession>
    <name>I4YAI4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958967.1">
        <property type="nucleotide sequence ID" value="XM_006958905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAI4"/>
    <dbReference type="GeneID" id="18474965"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64870"/>
    <dbReference type="HOGENOM" id="CLU_1099216_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAI4"/>
    <dbReference type="OMA" id="MATEMNN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="253" mass="29167" checksum="2DF71344A6602F11" modified="2012-09-05" version="1">MIEFPKTQSVDNICIPNDVKAKRRRPLSLPSFDFRLIAATLRSNKTESYKDVLNHRRIELGIDTLKRAVSADREKDDELAYEAYFQAMDSIFSSLNSDREFDKEYIEKRINCHLNKLGLRPVAYDNDKDVSWRSFVIDNAVSAAVLAKKSKIPEYIYRMITGLLDTLYELNSKLELSTKLIGAFDKTVTLFLRLDGNFDLHQWASEISWTLWEALLRASIAFAQADSAGTHNSRSRPRDREESDFKVETIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAK7</accession>
    <name>I4YAK7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_39173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958987.1">
        <property type="nucleotide sequence ID" value="XM_006958925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAK7"/>
    <dbReference type="GeneID" id="18472101"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39173"/>
    <dbReference type="eggNOG" id="ENOG502QTSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAK7"/>
    <dbReference type="OMA" id="HAYMDSG"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698732" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61986" checksum="FC6C28D71012215A" modified="2012-09-05" version="1">MQISTGFLKLAALLSTIGLTAAEWRYLSRPDLHIPRLEVTQNTGKTADGLLFVAPFTGSPVEDEEHPPHQPSAYILREDGDLVWSGFASYYSGWLANFQKAEYQGQDVLLAFEGKHNSAHGHGHGLLKVLDKSYNHITSIKAGHAKLIDKHEGQLIHDGKSALFQIYHPVPRDLSSFNGGDPQREWIVDSQFQEVDTRSGEVIFEWKSLDHVPPSHSNITLTSGQAGNGIGSVEAWDYFHINSVDKNHDGDYLISARDVNSVYKISGKTGEIIWTLGGRNVNDDFKHLDKASHFSYQHHARFQGVDEEGREIISLYDNSAHGTETDIGHAVFDAPTSSGKVLLVNTAGGKNKWTVETRQAFYPPDGLISKSQGSTQLLDNGNVLVNWGSEGAVTEFTSDGKAIYHAYFEKGHGAQNYRAFKNDWQSVKPSEDAALVGYVYGHLGKLILASSWNGDTEVASWRYYGATKKGGPLKQLGEVERNGFEARLELNHVKHDYKEVKAEGLDKDGKVIIETSREKVVDNAPLPPDYRQYENIGLNMGRIMISTGMNVFSHNYGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-09-13" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR7</accession>
    <name>I4YAR7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_29005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958744.1">
        <property type="nucleotide sequence ID" value="XM_006958682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR7"/>
    <dbReference type="GeneID" id="18471070"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29005"/>
    <dbReference type="HOGENOM" id="CLU_1355594_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAR7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697771" description="SPOR domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22935" checksum="309508A0A33348AA" modified="2012-09-05" version="1">MTMLFSMAILLISLHLARRYNFSYLFFTEENSGSLIVQDVKYSEVSSDGRVDAGPTCDDFANAKTPTIWGYVSKYSTAIRAIAATWIIVNNIKDLMSTPIGAREECNTRKIKNQEQAYWYILNGNCTAMAARNTLNSKINDTLFAFSNRRPAIGCIKMISGDYWGYVTIPPDDTNEEFDKAIKHCENNGYVIRATRRDYDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS6</accession>
    <name>I4YAS6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958753.1">
        <property type="nucleotide sequence ID" value="XM_006958691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS6"/>
    <dbReference type="FunCoup" id="I4YAS6">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS6"/>
    <dbReference type="GeneID" id="18474031"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60563"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAS6"/>
    <dbReference type="OMA" id="MLYWIAN"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="7"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="419" mass="46250" checksum="D5DF34F3E72C5043" modified="2012-09-05" version="1">MQQDKELDRVAHANYLTESLRSLPASMRVLDASRPWLIYWSLHSLLTLGISLDSASKSRALNTLLKCQNSTGGFGGGPGQISHILTTYASIMSFVIAGGPGSGNGWEDIDRKGIYNFLIRMKQKDGSFIVHEGGEVDVRGCYCALTVATLLDILTPELLENVDTFVSSCQTYEGGFAACSQNGSQFGEAHGGYTSCALSALTMVDSTRSTKLQTRFDLDALIRWSVHMQGLESELGGFRGRTNKLVDGCYSWWLGGSFNLLEYWQQGVDSTVDDDDDSWIDEETCLYDREALQGYILNAAQTPKGGLRDKPGKNADTYHTAYNLSGLSASQHYIKYEPDRAQEIAIDFKENTDDSIPELENARRLDIRKYAYASAMAWMPNKAAKSVRGGGSNITNPTHPVFNLTMSKSSAALKYFYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAU1</accession>
    <name>I4YAU1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vesicle fusion-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958766.1">
        <property type="nucleotide sequence ID" value="XM_006958704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAU1"/>
    <dbReference type="FunCoup" id="I4YAU1">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAU1"/>
    <dbReference type="GeneID" id="18474034"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60570"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011776_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAU1"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="724" mass="83682" checksum="4CFA1930FCD512C8" modified="2012-09-05" version="1">MVESTIVIDAFKSPDDLSKLSTIKNKLSKEKSLIDTKLKSNLAQHLDLTRDSLRSLYHTRSSVKQLTNNSNSTNKDFSNISQVAMIHRNFNQVEETVNNLRQMYSKISTIESWLDADKEDPMGSNNYLIPIHSELSQLETFKNHALYQANELDNQSRDTLLKHFHKLNALIEEFQLHLQDLSKHILDVVRYGDQSVVERLVQIVEHEQREDEKVTSLKLVIQANEDSKNDRFKQMQANSRSIKNMKLTLIDNIKESVDELFDAADEQHQDDNAAFLETLDWIYEDFQDITDKVQVLFPNDFNIHQVYIIAYHTRLNQSLKRILSSEPESAVLLTLYNFVKNYAKQMEKLNIPLEWINSPPLLDGKEQDLIEDYVQLLTRKLDEWTVNLMKDEKTEFSQRSQPPEIDGDGLWGMQGAVILFQMINSQADLAANSGQGGVLARVITECSRVIRSVQADWTEIINSESIQMNKKPEFVANGLGEYLIALANDQIKAADFTESLLQRTEVMVSDKYKTAIQKQLNDAMDGSLDVARKCIEIIVSIIFSDLKPAIKGLFGSAWFEESLVIQMLETMRDYLDDWSEFMNVSLRELLVESLMHEFLVTYLRMLKKCSKIKVLPFVEQIKADTLEAHTFFKRYRKAGDIQDDLDILERVVSLLTSSESMIYLDYFPFAKRHGPCLQFVQSLIKARDDLERRESKDMIETIYRKAEEEQFPEPDPPTIMSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY4</accession>
    <name>I4YAY4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958803.1">
        <property type="nucleotide sequence ID" value="XM_006958741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY4"/>
    <dbReference type="STRING" id="671144.I4YAY4"/>
    <dbReference type="GeneID" id="18475563"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69279"/>
    <dbReference type="HOGENOM" id="CLU_181953_1_1_1"/>
    <dbReference type="InParanoid" id="I4YAY4"/>
    <dbReference type="OMA" id="WIMLRIK"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="57" mass="6694" checksum="B6D7CE1387746A00" modified="2012-09-05" version="1">MAGGPRGFHAPPRFHRFASTALGASMWFWIFYKARQDLPHMLGWHLPFEHGDHDEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB18</accession>
    <name>I4YB18_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_64745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958833.1">
        <property type="nucleotide sequence ID" value="XM_006958771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB18"/>
    <dbReference type="STRING" id="671144.I4YB18"/>
    <dbReference type="GeneID" id="18474953"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64745"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1143305_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB18"/>
    <dbReference type="OMA" id="THVISWA"/>
    <dbReference type="OrthoDB" id="310096at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="27343" checksum="A4200F6074E1CD7F" modified="2012-09-05" version="1">MNRFLSNLAFNSPNPYDSAIKKVLRTVEVCNDIYQDPYSQTMSRSGEFLPRLWCMLNEPRLASIITWSADSTTVCLLDKDLFEKFVLPYVYKAKKLSSFYRQLRIYGFKRTTSVKDDAVNFKHREFSRNTSINVLYNIERHEYSERNKCKNEITAISAHAPSEANISSAPPHLPYMTAPSTTTFISKVSIGGYATSYQTPLAGTAPTTLHAPVPISPTEYSPILNEDFEVYDDVTIHREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB99</accession>
    <name>I4YB99_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958596.1">
        <property type="nucleotide sequence ID" value="XM_006958534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB99"/>
    <dbReference type="FunCoup" id="I4YB99">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB99"/>
    <dbReference type="GeneID" id="18473982"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60492"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_0_1"/>
    <dbReference type="InParanoid" id="I4YB99"/>
    <dbReference type="OMA" id="CEFLLRY"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="295" mass="32377" checksum="8A886915F5D6E75C" modified="2012-09-05" version="1">MSDIDNYYGYSTPDGNPTLSHAIAFTALYGIAFLVHCVLAGYTKQWWLYGTIVPFLILEALGWGGRCGDTRDSYIMQIATLVIGPTFLSAMIYVDLGVIGLQYGPNFSVLGPKAFAATFITADVVSILVQAAGGGIASAASKDNDIDTLRTGSNIMLAGIAIQFACIIFYSYFLIEFIIRYYKNKPVKSNRQDAVAIEPESQKNQRKLALRLTMLSVVSFLIIWRGIYRLIELKDGWDGSVIKDQAAFDTNDGMPMIIAAWLSFILHIGLLTPETNASIMSKGHVADHDSKEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBE1</accession>
    <name>I4YBE1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958636.1">
        <property type="nucleotide sequence ID" value="XM_006958574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBE1"/>
    <dbReference type="GeneID" id="18473991"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60503"/>
    <dbReference type="eggNOG" id="ENOG502SFIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1409807_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBE1"/>
    <dbReference type="OMA" id="KQHNPSA"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="193" mass="22060" checksum="4AA31ADDB1257F9E" modified="2012-09-05" version="1">MFSSFVRLGARRTQLTTKGGNKEYYKGTRTGYIDGYRTGPVGKHAGKSSNTFIIDDKKARVFVAPANFHKEEHVLKPYVERNAEIDKPWSILVAEHLIKQNQPSADAEDEARRVLESTTQSLNEYKQIKSGLNKKDKKEIHLLERAFGKKRVSKLLLEHKVKGPSKHSRNTYASGMDKEKYREILQSVQQQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBF5</accession>
    <name>I4YBF5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958650.1">
        <property type="nucleotide sequence ID" value="XM_006958588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBF5"/>
    <dbReference type="GeneID" id="18475535"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69157"/>
    <dbReference type="HOGENOM" id="CLU_1564105_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBF5"/>
    <dbReference type="OMA" id="DRMRYIN"/>
    <dbReference type="OrthoDB" id="3361897at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="177" mass="20640" checksum="CBB5EB4AB69483DC" modified="2012-09-05" version="1">MNFQEAYRRTLKSAYKAVYPSKRSKKQIYDLIRTDFDDMIDKYNQSDDKIGIFKEFNEKVKQSIDFYNSAGENLGKAHKVVKNLTDIHHSHTNWKGIRQRRKTLSISRWNAQKPPVEAAAPESKQAHKSREKHLQALDRMYYINAAPLYMGEVIAQAENTSGIILGKLRRPMRKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBP4</accession>
    <name>I4YBP4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_7832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958412.1">
        <property type="nucleotide sequence ID" value="XM_006958350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBP4"/>
    <dbReference type="FunCoup" id="I4YBP4">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBP4"/>
    <dbReference type="GeneID" id="18475829"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7832"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068101_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBP4"/>
    <dbReference type="OMA" id="ENWKIWA"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24592" checksum="8D55F405179B1E51" modified="2012-09-05" version="1" fragment="single">MPRRIQTEVHSSVSRLLRGNYLQQPPAWYAPVLRNLPSLPPMHATVEREDILKQDKPFISGSRNTSKRKLPNWREDRKPQKIVYPVDKIRRQFYEDFPFESFRSRSLTESYQVSDDRYETLCASPNGWSSLKQLTINPQPEDAIKFCLHLHNNHNISLSLAYIHATNQFSALKAELEVQKQAAIEEAAAYGASFAPTEIERGYELEERFLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS1</accession>
    <name>I4YBS1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958444.1">
        <property type="nucleotide sequence ID" value="XM_006958382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS1"/>
    <dbReference type="FunCoup" id="I4YBS1">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBS1"/>
    <dbReference type="GeneID" id="18473932"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60413"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBS1"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000100">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="201"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="372"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="592"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="99156" checksum="127E86B159F5EE87" modified="2012-09-05" version="1">MKNMETSKPAANTHAMLGLVRTFSCGGFVYITSTDNGTIHDMFMLIYILANVIYMPFGSYLTQNSLIRKTRQLLSLYFILSLLPMFYIYFLHKNRRIAGAYTYYAFFEWGLIIADILFDSMSLFDLEDTHIYISDSSRGTVLNINNIPMGKDHRESEKVMLKEDIPAKTPREVNKMPNKYIKQSSKVIYLTFMADTMLSLVWWTNFTALPLCIFYYSVWSLSFAGQEGLMLVTLSAGLIGIEELALFASSRDGKTVLTLVSFLGLFASKLEFPVLKLVSVSMAVIAQSISIASDWYRSRDRQQVITFMLGLLLHSTLKLLAHSNNPFWPIVNDTNGGYIKTGLVMAFIALLIRRCYGSDYCTSPISTQKRSNRCLIIGASLGSYIWALHTFLSDPSTLLSWSWTGFPSNGPHPMYNSSMIIVGFAIGIMSPEYLAISNIWHLFGTCCITLCYICDDWLSASGAFGFSIYLPSLGPVMIWNIKHCAPGRTMLAVFGTYTLLIVAHTFTVAYEFVPLGFLLRERTHVVIFTALAFIWLTTSRTTFNITYGDNDKAFKRYTKLLLVGIICAAHFILLNRINNSVVPQPYHTQDGILTSGIWTVHFGMDDEMWDSQIRMRDLIREAEVDVLGLLETELQSVVFGNRNLAQFIAEDLGYYVDYGPPSHKHTWGAVLLSKFPIKESQHHLLPSPQGELAPAISAKLDLYGNIVNVLISHNGQEESPLDRELQTTEIARILNTTYPEPALFLGYLVTTPHQKRPAPYGILFEDGRMLDIEPLDRRRWCEYIGYRSMRKIAYARISHGTVTDTELQVAKFKLYDTDESYHPQFDWYTFMDEEHIPDSYRFSNAFAGKGKDGHRFHVFKIPIYYQEMSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBX9</accession>
    <name>I4YBX9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_64420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958500.1">
        <property type="nucleotide sequence ID" value="XM_006958438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBX9"/>
    <dbReference type="STRING" id="671144.I4YBX9"/>
    <dbReference type="GeneID" id="18474925"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64420"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069856_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBX9"/>
    <dbReference type="OMA" id="QVIKDWR"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="25973" checksum="CCCF38B7079E159B" modified="2012-09-05" version="1">MSADLLGDETDNRLDPEVAASAFPDIEGVDGADEKFPEIPATGEASASPVVAAPLEDTPKDDIQQFESSFPALEEPEVSTGPEISTPSFVQSDFIQQTPSNQGIAAPLFSARTSTDPEPEPVREWREKRAKEIAERDTEAEKEKDEIKLKAERAIDSFYKDYNERKEKNIAKNKEDEQEFLNKRTDALASGTTWERICDLLDIDNVGNKQLARKDLGRFKEVLTGLRKQGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCK5</accession>
    <name>I4YCK5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958383.1">
        <property type="nucleotide sequence ID" value="XM_006958321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCK5"/>
    <dbReference type="FunCoup" id="I4YCK5">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCK5"/>
    <dbReference type="GeneID" id="18472915"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57463"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448491_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCK5"/>
    <dbReference type="OMA" id="NICQYAP"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="66695" checksum="3CEAA9E299596050" modified="2012-09-05" version="1">MREMNGLLKRVNEGNSNLTEDDITDLLENTTDILRTVVLHKLNELSGLQQLETRIGALDDNKYGDIIAILLSVNPEFATSLINRDILSFDPTNSLNILNSASSSKLGNNLIDDRSIFYLNSQFNSNDAQISFLSTLTLIKHNKHLNNKQSMHSHYDRISRLASTFDRLPDNVISIFLEALSYLSSTPLIADTLSRDVRLINLMLSTLHLPPTKQSTQLYSQEQAPRDTSIEFTLSTVLANICHYPQPLTEEQKTLKKLQKSTKQVDPEDEEYMSIEKVRGRNSRMLQAGVASTLSALSRSKSLLSRRNTSTVYLALITNDANRPNLLKDGVVKALLNIISQQPSPLTGDDLHANQALAKMTITTPPSTLYAPPITTAAIGFIRPLYEMLIHPDALQLQQFEALMALTNVSSVGPDLAERVATAFDGGVLSTAEECLLSSHELLQRASTELICNLVGMSESAFSKYTTSARSKVNCGILLALSDAELVETRLGASGALAQLCGMSPIVCAHILSDPAKFLRVIMALLEDSHLGLVHRALVILDATLEACKDILVSDDQAKTAIQSSGLVDTLKNLILRLANEPSGRDVLPILKDTLIKLKNCGISIQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN5</accession>
    <name>I4YCN5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SKN1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_68668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958038.1">
        <property type="nucleotide sequence ID" value="XM_006957976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN5"/>
    <dbReference type="GeneID" id="18475449"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68668"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_3_1_1"/>
    <dbReference type="InParanoid" id="I4YCN5"/>
    <dbReference type="OMA" id="TTWSGDY"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="125"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="664" mass="74649" checksum="8F5AD1B16C72E8C7" modified="2012-09-05" version="1">MAVGLGLLDERPQHKRNFYKGWSQDEEIDDLFHDPERSAIWDETYKATNILNSRAFCNVGLLAVTAFGLLSLFAGYPLYSIYNASKQINHHGQYANYNKTGQIPWGGPRRGLIDPDTPEESRTRVGTDGHVYELVFSDEFNQDGRTFYPGDDPFWEAADMHYWVTHNLEWYSPRQATTNNGSLRLTLDTIASHDLEFEGAMLTSWNKFCFTGGYVSANVQLPGKNDVWGIWPAFWIMGNLGRAGYGATLDGMWPYTYDSCDVGTLQNQTMGDYPELAYTSGIEGKALSFLPGQRLSRCTCANEIHPGPMHEDGTFVGRSAAEIDVFEALVDPAIDQSLVSMSGQFAPFNAHYDWRNDTEMYLKYPEKDRYNEFQGGEWQQSTSIRLVTDPSAYEKSGGNYSSYGLEYNPGYGQEGYIAWHIAEENRYTVFADSMRAVPDLGISDRLITAEPMYMIINNGISNNFGGIDWDGLAGSFPNVMSIDWVRVYQRRDRINIGCDPPNMPTSAYIEYFKDAYTNPNLTTWEALGEKPVKNAILHQNEPDCSDAKKLIPDELIGHHNIKPILPATLRPPLPAPEQPGPLPPMPPIPPAPEFSDIPENQRPKVYEYFENPPPIMRPIHNLGPPGPPSLPNAPPFDRPAPNANDHEDDKGDMGDEDNEDMIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCQ4</accession>
    <name>I4YCQ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958057.1">
        <property type="nucleotide sequence ID" value="XM_006957995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCQ4"/>
    <dbReference type="STRING" id="671144.I4YCQ4"/>
    <dbReference type="GeneID" id="18473823"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60226"/>
    <dbReference type="eggNOG" id="ENOG502RYFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057756_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCQ4"/>
    <dbReference type="OMA" id="WDQTVAS"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="35831" checksum="6B3EDA60CD2CDD70" modified="2012-09-05" version="1">MPKELLNISPLYSLVGVYRLITDEKVRNPIWLICRKGLARGAISALLWSLSTWKIQKKIVATFMSNSPKVLQYTTKALENHIPLLTFATFMFVSAQATAILQFLLYKRIAESKKIAYDLTIQSRAKSDSFWGPYVEEYNLETESGKQLKLRAEKLATSRKTGWRGLFEGQKRSKLLNLFITKVILLPLDVLPGVGLLLGAALRSVALARRLLKPYFVKKGMTAYEQELFIQERSFELRSFGFMAALLERLPIVGLLCSIATPIAAAMMSVDFEKRQNELRGKSDADKERYENTHVDSLKHRSRSHDTDNVTLPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCR2</accession>
    <name>I4YCR2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958064.1">
        <property type="nucleotide sequence ID" value="XM_006958002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCR2"/>
    <dbReference type="GeneID" id="18472895"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57266"/>
    <dbReference type="HOGENOM" id="CLU_427736_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCR2"/>
    <dbReference type="OMA" id="HPINTAG"/>
    <dbReference type="OrthoDB" id="10676054at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="640" mass="72581" checksum="37B1C2348AEECCB0" modified="2012-09-05" version="1">MKEQGIEHESIVEDTNVNTEESSDIISLPGSWEISSFNIQFLFVSSHLLSNDPVNIPYPENYLRWHYIQLFIITFTLATDRILTLIVILVVSSIGTLVKSSKKAESLSYLAIIHDLFVDNDKINYTILSQVGVSIGCKTRLYDCLIDLQGMYMSMSDTLGKLSEDQELKALKAMYARHEDGKDRRSHTSQVFPGNERKLDLEIELETPRTSPTITYIQSPVNKAFNIGRDDTNRRASRQRAKSHAHPPPLRPPQSVRQRAVSQQHLRVDSERNPPLLMSNSFGTPIGHISPAPSRKSSLVDKQQFVKPIEEPFEEHSSPEQTVKPSDITPTKPQPVLSKTRLWELRQNLHQERKELVCAIIALQYTKIADDYWRKVRDLTRDFATNLRNLNGRMQEGLDILDEPREVDTDDKKGKLTLDTLRNLEKAHDVLFECYTRRQYEGYYAAHTHLSQALKSYAKGIDEGVSCASRASKKPNRGGLELHLRNTHEEEDIADNSHTDKEHFGDEGTNDQDDVTEYLLNQTNAGSLPKRGGDEVVFDGENVENLAIIDETVDDNFLPPDQPDRASKRAGKEVLDELMGILGVERKKPASETIYNEQLNHEETQDNDNTNDDDNNIEEPPANPNAAREAAQRAVTSFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCS0</accession>
    <name>I4YCS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_60231</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958070.1">
        <property type="nucleotide sequence ID" value="XM_006958008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCS0"/>
    <dbReference type="FunCoup" id="I4YCS0">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCS0"/>
    <dbReference type="GeneID" id="18473826"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60231"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCS0"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="12"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM21762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="742" mass="83093" checksum="EE964B407805343A" modified="2012-09-05" version="1">MSANNSETVRSLLKLVILVCIAGAAVSSRLFSVIRHESIIHEFDPWFNFRATKVLVSQGFRNFWNWYDNTSWYPLGRATGGTLYPGLMLTSGLIHKILHNLNIPIDIRNICVLLAPAFSGLTAYVTYLFTAEVKDERAGLLAAVFIGIVPGYISRSVAGSYDNEAIAIFLLMFTFYLWVKSLRLGSAFWGAITALAYYYMVSAWGGYAFIINIIPLHVFTLILMGRYSPRLYISYCSFYTIGTLASMQVPFVGFNPVGTADHMAALGVFGLLQLVAFTTLVHSHLPSKQQFETLLKATLIAGSALGIVGMAFASQKGIIAPWTGRFYSLWDTGYAKVHIPIVASVSEHQPTSWPSFFFDLQMLIYLFPAGVYFCFRSLSDHVKGEASVFVIIYSLFGSYFASVMVRLMLTLTPIVCVASAVALSTLLDSYIQEPAETEQVAQDTSEKKDKKTKKDKKDKSIEATHAKIIQKIQEKTGIKAPDARLLVIVNVLLMLVLFVFHSTWVTSNAYSSPSVVLASKTPQGDTLIIDDFREAYNWLNQTTSEDAVVGSWWDYGYQLAGMAGRTTLVDNNTWNNTHIATVGKIMASPEEVSYDILRKHDVTHLLVVFGGLLGYSGDDINKFLWMVRIAEGIWPDEIHERDYFTPRGEFRMDEGAAPAMKNSLLYKMVYHKFADLFGSRPAVDRVRQVKLPKVGPELDSLDEAFTSENWLVRIYEVKEPDFLGRSFKDAKAFNEGKLRTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU9</accession>
    <name>I4YCU9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958096.1">
        <property type="nucleotide sequence ID" value="XM_006958034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU9"/>
    <dbReference type="FunCoup" id="I4YCU9">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="GeneID" id="18473836"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60249"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="I4YCU9"/>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="550" mass="60231" checksum="A6529E7B6C0850FC" modified="2012-09-05" version="1">MENKNYVETYNRDRNVIDFNESRGSLAFGDSSTKDDELAVNLEAEEKVTPFVVFLTLAAAVSGMLFGLDTGIISGALVEMDDAFETELTDTYKELITSATTLGALISSLTAGIVADIIGRRLALAGADVFFTVGAIVQACAQGVWTMIAGRFILGLGVGWASCVAPLYISELSPTRLRGRLVTVNAVFLTFGQVIAYAIGAAFANVDDGWRYMVGICAVPSGLQFIALHWLPESPRFLLSRGKDDGAIKVLSRIYPYINQEDMKAKLYVLKQGVKESLEISKRVPLYKRIGKMFTEPVILKVTIIAAGLQAFQQLSGFNTLMYYSATLFAQIGFDQPTATGLIVSGTNFLGTLFALKYIDVIGRRRIMLISAPMLVVSLTFASVCFHFLTIETGGQFVDGHNYPKVWSALVLVAIVLYVLFYAVGLGNVPWQQGELFTLEYRGIGTSLATASNWSCNLLISLTYLSLINKITASGAFGFYAGLCFLGTLFVIFCYPDLTKLSLEEVQDVFSGNSFKDARRRAEVMRKSKSEVLYRLHEKEGGLTPDHPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX7</accession>
    <name>I4YCX7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958121.1">
        <property type="nucleotide sequence ID" value="XM_006958059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX7"/>
    <dbReference type="FunCoup" id="I4YCX7">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCX7"/>
    <dbReference type="GeneID" id="18471480"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32390"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_2_1"/>
    <dbReference type="InParanoid" id="I4YCX7"/>
    <dbReference type="OMA" id="GWDMQDL"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="81"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="405" mass="45742" checksum="7954BB34D2A7C40F" modified="2012-09-05" version="1">MKFNILALAAAVAASPLQRRYGDLIRGVNIGGLFVLEPWITPSVFDQTGNPAIVDEWTFGQYQDHAQAESAINSHLETFFTYDDFQQIKNAGLTHVRIPVGFWAIETQGEPYIVGNRLNKLKEVVRWCRDIGLKVWIDLHGAPGSQNGLDNSGLRTNNVQWHTDQNNVDRSLSYIQTLTDEFTKPEYGAIVEAIELLNEPQSATHPEMLGTLKSFYQNGYGIVSQKAATAIHDGFLDVNQWNDFLTSPQENVYLDTHKYQVFSDQQLQSSDEQRTGAICQFKDKFAEHTANQHWVITGEWSLATTDCARYLNGRGIGARYDGSYSGSSYVGSCQGKTGDGSDWSEEYKNQLRQMWNTQVDAFEGGRGYFFWTWKNEEAADWSYQRLLQLGIIPQDPNSYQHGICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD54</accession>
    <name>I4YD54_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_17974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958020.1">
        <property type="nucleotide sequence ID" value="XM_006957958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD54"/>
    <dbReference type="STRING" id="671144.I4YD54"/>
    <dbReference type="GeneID" id="18470747"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17974"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_5_1"/>
    <dbReference type="InParanoid" id="I4YD54"/>
    <dbReference type="OMA" id="VLYNTYW"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="34864" checksum="17BA53A17FB5EDC3" modified="2012-09-05" version="1">MPDAAIRVASRQTEHRVDVTDRDSLRGVLEGSDAVINTVGLLQASRKTFEAVQHEGAENVARITRENNAKLVQISAIGADASSRLPYPRTKALGEQAALSECPDCSIVRPSLIFGPGDSFFNRFAWLAKYMPFLPVFGTGETLFQPVYVGDVAAAVALCAESRSDERIATRVNGKITEAGGPEVFTYRQIMQLVIDYSGNKRPIVSIPWSIAKMQAFVLENLPMPPVLSITRDQVEQLKKNNIVTPKHEQESNAISFKELLGDFSHIQPSSVHEILPTYLSPEGHEMAVTMDHKTREEERRKKRLMLRDKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDI9</accession>
    <name>I4YDI9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957838.1">
        <property type="nucleotide sequence ID" value="XM_006957776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDI9"/>
    <dbReference type="GeneID" id="18474866"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63773"/>
    <dbReference type="eggNOG" id="ENOG502QWQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010457_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDI9"/>
    <dbReference type="OMA" id="PCALWRP"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="2">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="1">
        <location>
            <begin position="188"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58323" checksum="0ACE597ABFAEC3C7" modified="2012-09-05" version="1">MVELNAVQCPINNVILYQDRAQIDRNLQVDVTHGQNSVTLKNLTNAIDRDSLKVTTTTSDLLLFDVIFHPSTSKRREPEELVKARNAHRLLVIEKDVLLHEIETLNNFGTTINTSQTADPAKTLENYLNILPGRSLNAHTKLLDVETQMEVVQEQIHDLEQEYYRCQSGADSSVEIIFSVQSTGLVMLNLSYMVNDASWSPLYDVRASTDGTMEIDYRAQVWQSTGEDWNAVSLILSTSTPSVGSEIPTLIPSKVQIKPPPQPRGPQMRMLSKAAMSDASAVPEAALFCANVSVQNHTLSSSFTIDGRTTVASDNKEHKVSIRKLTLDSTMKWICVPTQSERAYLQSVVTNDSDAPLLHGDALVFLDGSFVSRSVVPEAAPGASFDLSLGVDKHIKVSTHHQKDHYNGIVSKGILERFNTDARTQSRTKSATFTVHNTKQNKASNMNVVVRSQIPVSVDERVKVVIKEPSQLADTDSQPDPSTKAEWIDKFDGTFSWSFELGANQSKDLQIDYDLEWPEDAQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDJ1</accession>
    <name>I4YDJ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957840.1">
        <property type="nucleotide sequence ID" value="XM_006957778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDJ1"/>
    <dbReference type="STRING" id="671144.I4YDJ1"/>
    <dbReference type="GeneID" id="18472882"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57135"/>
    <dbReference type="eggNOG" id="ENOG502QQ86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891993_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDJ1"/>
    <dbReference type="OMA" id="KFIPDRP"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="33027" checksum="33697541C059A711" modified="2012-09-05" version="1">MILDGHSEPILDLAICPYDSSIIATASEDSTVRLWKGDRDSYKSYKAIVNFEDAVVAVLWHPKVENQLFLCCGGTIFLFDLNISSPLIKASEASKTWNVTEVEINSISIDRKAQQVAFCDDSGAVGVLDTSTGKTRLFRYKHANIASKVAYKNGKDGDLLSGSYDSSALIWNTSKGTIGDTLDLSTRQGQSMAPAFVLSLASSEDGKKLAVGSGNGSVWLSSSRLSNAREVTAHNGPVVGLAFVNGRLISCSLYQLCIWKENLEGVDSTTTIDGLEKANCIATTSTHVYIGGFEKNGKGRAVVLPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDK1</accession>
    <name>I4YDK1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_37524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957848.1">
        <property type="nucleotide sequence ID" value="XM_006957786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDK1"/>
    <dbReference type="FunCoup" id="I4YDK1">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDK1"/>
    <dbReference type="GeneID" id="18472020"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37524"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_8_1_1"/>
    <dbReference type="InParanoid" id="I4YDK1"/>
    <dbReference type="OMA" id="AGPRMQW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="324" mass="36701" checksum="44BB3F6A293E9AA4" modified="2012-09-05" version="1">MSIERADEQMEILEDNNPESIVYDSSSPQSTSTSSLTWISWFCSLPGHEYFAEVSEDFIEDEFNLTGLAGIVGFYKEALEMILDVEPEESLKIPDVSIVEHSAEMLYGLIHARYILTRIGLQQMVEKYENGHFGFCPRFCCQSCPVVPCGRSDTPGVDTVKLYCPNCMDIYVPPSSRFQGVDGSFFGTTFPHLLFHTFKDLQPSIVLSENENGVDYKAVVGSQYKPAATKIYTPKIYGFKISEKSRSGPRMQWLRMRPNTVEELNSVDNKGNIKNSDLKKSSDRKSSNKSKQQGKLFDEDDDDEEIHSESEEEEDKPKPQPIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDT0</accession>
    <name>I4YDT0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_68593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957924.1">
        <property type="nucleotide sequence ID" value="XM_006957862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDT0"/>
    <dbReference type="FunCoup" id="I4YDT0">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDT0"/>
    <dbReference type="GeneID" id="18475434"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68593"/>
    <dbReference type="eggNOG" id="KOG3321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051208_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDT0"/>
    <dbReference type="OMA" id="MPCSGTV"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="20465" checksum="8CCB1092EE894258" modified="2012-09-05" version="1">MLSRLNLFKTKNIKNVRYRANFPPVLQAIEYDNQPSTNNLYLENNPPSVFKVPEKHKKSHNIPIANLQLKAYDNEHLDFFADFAQRAAYHLGIVLTGPAMLPTRHERFAVLKSPFVHKKSQEVFERRTHTRLLKVWDSDDQVVQLWIQYLNQHAMKGVRMKFEQIKYEKFTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDT4</accession>
    <name>I4YDT4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957928.1">
        <property type="nucleotide sequence ID" value="XM_006957866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDT4"/>
    <dbReference type="GeneID" id="18474875"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63867"/>
    <dbReference type="eggNOG" id="ENOG502SNEI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064800_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDT4"/>
    <dbReference type="OMA" id="CISWIMS"/>
    <dbReference type="OrthoDB" id="3222065at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38774" checksum="C462001BFE9A7C52" modified="2012-09-05" version="1">MNSSALFELADDRHLNAYFGIIIAGSIGHLILFIITIASKRIQKNIILLQFYALFCIILWFDAILLWTGHKNSLTEDIPTAIRIINATVRGTGLIMNSCTSLIVTMRIWATVNAAKATSFSQLKDYIDSPIIVVIPWLLGMPFFIAHLVASIQDTNNVIRTPYFCVILNEKLNLATALTSTVVMFVLMIVAFWTAIIFIRLRVSQIGLVKVRKTIDIQLTSRIVLFLYYSITSLVVLLQATIEFQGFKTGPTLTFAATGLVAFVIFLIQADVLKAIAIYFNLSDSPTPTNSHSQSRSTNTTEALIPRRKLSLSIFLPPKARVRDNNINNTVSQSTSKSASTQSFPLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDV8</accession>
    <name>I4YDV8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_28384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957950.1">
        <property type="nucleotide sequence ID" value="XM_006957888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDV8"/>
    <dbReference type="FunCoup" id="I4YDV8">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDV8"/>
    <dbReference type="GeneID" id="18471039"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28384"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="I4YDV8"/>
    <dbReference type="OMA" id="FARNEHK"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="171"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="338" mass="37478" checksum="0C7DA3464203A690" modified="2012-09-05" version="1">MTEFKAFRGQQDGKIVQSTGKVPELGQHDVLIKLTHAGLCFTDVHYVQAGIALGHEPVGKVTKVGTDVRHLKEGDVVGYGYNHGSCDTCDECRIGNDTLCGSRRLYGEADTDFGAFGEYAQVEERFVHKIPDNLAPEYAAPLQCAGATVFAPFLKYDIKPIHRVGVIGIGGLGHLALQFANKWGCSVGAFTTSESKADEAKSFGAHDVIVTKRPDGESFVPKSDAEKFDFIICTVSSQVPWDNYFDCLKPRGQIIPLGVDFGKFETNRYFSLLARENKIGGNIVSNRYQHQKMLEFCARHGIKPAIELLDLTEENINKALGRLQKNDVRYRFVFKHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ3</accession>
    <name>I4YDZ3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957980.1">
        <property type="nucleotide sequence ID" value="XM_006957918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ3"/>
    <dbReference type="FunCoup" id="I4YDZ3">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDZ3"/>
    <dbReference type="GeneID" id="18473806"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60197"/>
    <dbReference type="eggNOG" id="KOG2053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354200_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDZ3"/>
    <dbReference type="OMA" id="WKRREHQ"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="793" mass="90763" checksum="C947A869046D9C54" modified="2012-09-05" version="1">MSTRTSFFEARKVAPIYDLLEDGHYSIASRQCETLLQNKPDWELVRALLAFSYCRSARTDDARKIAYNLADIKPKNSDTMAALNLTLTDLRAYDKLAEMYKLLWEQNGSINDNNGRLTAMAYIKAQNWKGMQSVSMRLSKVSQNANSVKFTWWTIAGLFMQAQTAKNEQEKSLAFTLALRLADSVQCQSDEEVHLLVRLFWSSGNPRKASDLLVEHDKEISNSLALEELQWDVWKELDEVSLIKNKAKSLLEGGSGNYAHHTAYLSTVKDNREEAVALFEHLAQQNPKERGHIIALMEIERKFSKNDNLVSLLERYWHLFKNKPVCFDDIITFMKYLHHEKYNISSLNEVFIKDFNNKDESLDTRLNAAKLVRCLSLNIALEKEIQNADLYAQLHKEYLVAGEGVPKTDLHPADDWAVLSGISYISAYSKSRDLSYLTKASENMEFALSKSERSYKLKLLLISIYRITGNLNMFDLIRKMRIQSVQQDTLTHHGCGELSTFAMSSLDVVGVLPNTNSSFSGVWGQAERECSEMLSRLFDYGTWSHLEDFSDFAGMLKYSLHKWILWFEDVRIKLGESPKIEGSQLEDWLSSLDKLDALSDNLVDNRDWSLLPSWAPFEESETREQLHILTYQEGNWLKKYSEIYRRIFSVVLNKPNECTNDGLEELTSAEKILEEISHLIIKYNKQGSDAEKAPVGAEVLDKFGDFSKLLTEAALPCDKLHAAKVSIETWSLIRIGIAPPSKKKKTKSPSYGLYQGIVGQLQEMVKDWKTDDIDNLWSRLHSLVDTKIDYKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE54</accession>
    <name>I4YE54_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957510.1">
        <property type="nucleotide sequence ID" value="XM_006957448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE54"/>
    <dbReference type="GeneID" id="18472871"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56931"/>
    <dbReference type="HOGENOM" id="CLU_344588_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE54"/>
    <dbReference type="OMA" id="HNAENEM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="821" mass="90907" checksum="8DF6176E7F98AFC2" modified="2012-09-05" version="1">MQVDDALFQPARSRHKLEELLNKAEMPYLVDNDKTPEPKSKYQEFKFPLNDTTLYDPEPLVFPNSTLQSQSKSFNLAGLSVSGLQEEPAGGELDGSEAGTIFSDSMTNGSQESSPVASNGKLHDDFVEETPMKKTIDFNVGMPQRTDEPQELQQEQSLSAYHRPLSQRPPPLPITRSQSVPVEDEIMEVPTKNHASVPASPASEVGAMPAIPISMASPSKTSPLLSNIPISFKERLRNSMAQGSGQFKSSQRENPQDTPRANLTKSQPHSAPSTLPSTTPKVSPPRRRTYVDDYVDNVSEVDIETASSSSASLPQVSSSLENSPVKQPPAPTRPRWSFGGTRRSFSGGMRSTDVEKAKKEMAEEGKEKENAVDNTHVNETVNQNDTQSQSELKHYEEYTAPIKEEYQSTKPQSASPARSILRSPHRSALVSPHKSSLKKNSNGGSNGGSKSVSFIQGLGVEDDEDEGNSEDSEEFINHAHEALEKLNDSPEKSRDGNNSNSFERFLKATNRVSPSDSTELSAADLTRSRPNYSVMQTPQAPGFYPMTPANIPRNKQSTPVKGEQEEEDAPGSPEFDVTKLGNNFELSSGRAPGFYPMTPAYKASPMSSADSFDVVDVDDNESNGGGSSNDKPNVYLNRPATSPRKATNNPPDASLFVALSDIEEALRSTAADVERRKKERRSQSQNKLLDVFKTDKSNDGLAKKAHNRTIDALAAYNEYTKYDSRKVDRSKVTQKPPKRSNAIVFLMLFTQLAVGYLILQDRHVYNTLFNSFLTNYFDPLNPDIYVSEYSREYPWENSTFEYHTILDRLSEYVYGRPWPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH1</accession>
    <name>I4YEH1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_50897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957617.1">
        <property type="nucleotide sequence ID" value="XM_006957555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH1"/>
    <dbReference type="FunCoup" id="I4YEH1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEH1"/>
    <dbReference type="GeneID" id="18472538"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50897"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="InParanoid" id="I4YEH1"/>
    <dbReference type="OMA" id="TQIWKLC"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="29670" checksum="6033BC23E6F5704C" modified="2012-09-05" version="1">MTNEFTKIEPGGSLLIAWQLKDKKVVLIGGGEVAAGRIVNLLNADAKITLIAPRKGLNKEVAYRIDSGQIHEFIDREYNNEDDLKGANMVFTAIDNVEISRHIYNVAKSQNIPTNVADIPPNCDFYFGSIVRRGPLQILISTGGQGPRISAKLKSIVEGALPRSIGPAINNVGKLRSKLRSIEPTVGGKPGAKRMKWMIKVCDNYTFDELAEMSEEDLDRILKGYQDNEIPKRSLLDISKVLSAIKSISPTIVGMVIGSVMTYSFIGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEI5</accession>
    <name>I4YEI5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">WALSEDRAFT_68352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957627.1">
        <property type="nucleotide sequence ID" value="XM_006957565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEI5"/>
    <dbReference type="GeneID" id="18475379"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68352"/>
    <dbReference type="HOGENOM" id="CLU_1579719_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEI5"/>
    <dbReference type="OMA" id="SNQDVEM"/>
    <dbReference type="OrthoDB" id="3358442at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="169" mass="19190" checksum="244A3ED316C8E73B" modified="2012-09-05" version="1">MSANEIDKLNQTDKDISKLLKLASDALKALLPPSNQQEREELEKQHQKYTELSNQQQSQPQITLWGDEDPNEDYNALEQDEAQDAKFVDTTKSYYSLLNSIQTDIRTAIAHLRNERISPRVLQPNGLTKGVHQSSNLSLGAQRIEIDVIRNLTTIIKQLSSKDVEMTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEL4</accession>
    <name>I4YEL4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957653.1">
        <property type="nucleotide sequence ID" value="XM_006957591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEL4"/>
    <dbReference type="GeneID" id="18471421"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32079"/>
    <dbReference type="HOGENOM" id="CLU_1983297_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEL4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="126" mass="14136" checksum="C1546E629920BB36" modified="2012-09-05" version="1">MKRCTKASSGDTIFCTASHKDWVAEERAKPGTNYCEIPVCPLKATGRGPHCNIYHSRENTQFFLDRDVTKPICSAEGCDYHTNEDEPFCVLGHYTQLKTFRNNKRRPAENPEAGTSAGPSKVARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP1</accession>
    <name>I4YEP1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin depolymerizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_68388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957676.1">
        <property type="nucleotide sequence ID" value="XM_006957614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP1"/>
    <dbReference type="FunCoup" id="I4YEP1">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEP1"/>
    <dbReference type="GeneID" id="18475388"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68388"/>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031995_0_1_1"/>
    <dbReference type="InParanoid" id="I4YEP1"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="172"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="37176" checksum="DEEAE85870321841" modified="2012-09-05" version="1">MSVNSGIQPTAALAREFEDANTFTSTTRCIKVEIQDEQLKSTHKTEIKGDENVDYAELYKILSQNIPAFLLFKQDNKKFRIIHYAPESASIKDKMVYSSSRASLEKQLGSQFFIKTDFIDDIKQFSDDANAESHPFKVVEEADKPYSEREKRLNEIDNLIKSSTSLSKVTQSIKFGWNDDVTQALNGIVNGEHNFVQCAIDIKTETIILEDKKDVELSNLKENISTVEPRYTIFKMTNGQYIFVYTCPPNSNIKSRMLYSSSATNFPSSIQTAFAINIKKKFETNDPSELTEGHITAELNPTTAGSMTAEIKFNKPRGPANRRRVIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP6</accession>
    <name>I4YEP6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_44888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957680.1">
        <property type="nucleotide sequence ID" value="XM_006957618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP6"/>
    <dbReference type="STRING" id="671144.I4YEP6"/>
    <dbReference type="GeneID" id="18472346"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44888"/>
    <dbReference type="eggNOG" id="ENOG502S1MF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070890_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEP6"/>
    <dbReference type="OMA" id="PRINDIY"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="292" mass="34682" checksum="A58A1A1353E44896" modified="2012-09-05" version="1">MRRSKLKSNWFRILLVVYFILSLFIFWRWTAFRRTLPTLEVVYTYHHVPLTLFHGYSAYIHYNLFWKFRIKKTVYVKKEYKESEARLLRWSFDNVKYLDNVGREGGTYLHHIVHNWEDLADKTLFLQAHSQWHEMTHGRLRYIDSSTGFLSLGLYVLSQCGESWPGSYPQMKSIWSLFHGEPCPENEHQLSTWSGQFVVSRHRIRHNHYKNYVEMLHLMTAPSDHPIYDESPDDWTPPRDPINPYLGHSLERSWPIIFNCNQPTFATDTTHCGGEVLSGSPDCQCFDSENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF80</accession>
    <name>I4YF80_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957288.1">
        <property type="nucleotide sequence ID" value="XM_006957226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF80"/>
    <dbReference type="FunCoup" id="I4YF80">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF80"/>
    <dbReference type="GeneID" id="18471375"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31830"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="InParanoid" id="I4YF80"/>
    <dbReference type="OMA" id="REAHDWT"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="32733" checksum="9464FDDFE57371A8" modified="2012-09-05" version="1">MSATASASASASTTTEVKQHQSINDQPKSLTERVSRGDKEGKIKLEGIPKFEDKYEEREWVKEHMAAAFRFWGRMGYGEGLAGHITVVDPVDPSCYWMNPICVHFGVMTKSKLALVGPDGHVRPEGAQLPINTAGFYIHSSIHKARPDIKAAGHTHTLYGKSWSVFGKPIDIMSQDSCLFYNNLAVYKNFGGIVLAQQEGENIAAALGKAKNCILQNHGLLTVGDTVDEMAHSFHALERACHMQLLTEAAAANGHQKFVIDDEDAAFTAATLCDPEATYLNFKPEFDLLIETQPDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF83</accession>
    <name>I4YF83_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957291.1">
        <property type="nucleotide sequence ID" value="XM_006957229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF83"/>
    <dbReference type="STRING" id="671144.I4YF83"/>
    <dbReference type="GeneID" id="18472858"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56806"/>
    <dbReference type="eggNOG" id="ENOG502S8VV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483658_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF83"/>
    <dbReference type="OMA" id="QLSWQHE"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="564" mass="65575" checksum="931AE4B3600870E1" modified="2012-09-05" version="1" fragment="single">MSNEYQENNYTRIDLTRSYDKNINSLKRIMVHLPWWSHFFTILIILYCCERLYAKLSSISRESSYRLEQRRRYGIPDSDKRSFKQALAAANASRRQRVKDIQADEERQRLDEKEESSQWRMLGKSTGWNPHPSRYSPPALPGTLEESYEPVKYDYIPSTSSIYYPNNEELPSLFERDVENDRSVILDDLNSSNEHQDEVNQRTRKRSMDESSYIDQDTLIKRRRATSISTNLSNVSMNEESVDNDYSDDNDSRMSITPQNENRGRKRSFDDTSEVSVVRTRYKKAPKNSEEWTDMSGTTYKYDNGVKKRLETIKEWRSKYNMPKDSQHPDRNIKLRVYVEKWITDDDYELLLQKNELGWQPDEDELSSVNESSIYNPDEEVSQQSSNKLSSTNSRKSSSVYYMTRTPIKRHISNRSNGVSSITSSPPPLNESTLQSTSRLRVNKKKKSDLSLSTTFGDAEKEKRKEADLLKEIRNEKRIKKEKEQEEEQRRKDEAHKTTIKKEQPEGLEEQEVKSTTPTLNLGNLTSTNDKVPKSSGAMSNTDAKTDDKKVNLPSFSFGSTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN8</accession>
    <name>I4YFN8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_50770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957435.1">
        <property type="nucleotide sequence ID" value="XM_006957373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFN8"/>
    <dbReference type="FunCoup" id="I4YFN8">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFN8"/>
    <dbReference type="GeneID" id="18472535"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50770"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106411_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFN8"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="126" mass="14319" checksum="5A2520930148B710" modified="2012-09-05" version="1">MKVELCSFSGQKIYPSKGRLYVRLDNRVFRFANGKCESLFLQRKNPRKIAWTAFCRKLHKKGVTEEVQKKKGKKSTKNARGIVGLDLEAIQAKRSQKPEVRTAARQEAIKQAKEAKQAKANATKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG82</accession>
    <name>I4YG82_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_15794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956844.1">
        <property type="nucleotide sequence ID" value="XM_006956782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG82"/>
    <dbReference type="FunCoup" id="I4YG82">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG82"/>
    <dbReference type="GeneID" id="18470676"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15794"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018004_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG82"/>
    <dbReference type="OMA" id="HHMIMTR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="12"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="250" mass="29281" checksum="EF4EF685C93C5034" modified="2012-09-05" version="1">MEKSIFGLEPSDEFIKEVSDWIWKHARNCEHKVEVEAKIGIFVDQTGQRAELPVAVETILTNTDGLRFISDMTISQHKHYNKILNDRTSQSSQTPTRIQYAHSKELDSFYPIGKGQRKIRVTKDLRTDQVKDVIEKVRVADLAIYSPKRLFDWRISINMEIPQTVPQNQNMTYSRKKDRLSYTQQEMQVDLTQVFSPNSETPSHELELEMHRPKFLIEEGFKRERGLPNMYDELIKVFVSNVRLLVRNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB5</accession>
    <name>I4YGB5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957046.1">
        <property type="nucleotide sequence ID" value="XM_006956984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB5"/>
    <dbReference type="FunCoup" id="I4YGB5">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGB5"/>
    <dbReference type="GeneID" id="18473519"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59725"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_4_3_1"/>
    <dbReference type="InParanoid" id="I4YGB5"/>
    <dbReference type="OMA" id="CFVSPAC"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="75"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="12">
        <location>
            <begin position="434"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="697" mass="78528" checksum="9B32905DF17AFA86" modified="2012-09-05" version="1">MVEDTTSPNNQPAPLYETVTTTVRKYYRHPPSESHAGLLEPPSELIRMPFSGLVRSGYVYDYEMTRHAPFDEDDHPEQPARITSIYESLNNSQCIKRMLKINSRNVTRAEVTLVHSPEHWDRVNMLAFIPEVELRALIPLHERMSIYVNPMTTYAALLSAGSLLELTKAVCDERIRNGFAIVRPPGHHAEPEQMMGFSFFNNASIAARWAQKNYPNSVKRVLILDWDVHHGNGTQRAFYDDPSVLYISLHRYENGTFYPGSDFGGMNMTGSGAGEGFSVNIPWPHAGMGDPEYLQAFNQVVMPISQEFAPDLVIISAGYDAAINDPLGENLITPLGYAQMTHQLSSLAGGKMVVALEGGYNLDSIATSATSTTQTLLGEIPPQAPFNSVAKTTAMETLHDVCMVQSKYWKSVSPKSNVNSSLQPSSENVTSIYEVLSKYREQLLYEKYNMFSLDITDEEIKRRFENQVMATSDLYSVDTLLVNVHDFGNLLFESKNNGEIKLDKSFLVDTTERILDMAESKKWGVIDVNIFHNFANQSRQTRLLRTQIDPVKDLLVWLWDNFIDLSKPNLKVVFVGFGSACAAITKFFEMRRSTVEKRVHASIYIPGMLDVPRVLKIMKDWYESKTLVIIPSVHDHVENGKPFKSFGKVLASTESSSWVLVEKHYDDILEWISSRNGDRLSPPSSVFAEGSNKMEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH0</accession>
    <name>I4YGH0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1212-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_15825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956847.1">
        <property type="nucleotide sequence ID" value="XM_006956785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH0"/>
    <dbReference type="FunCoup" id="I4YGH0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="18470679"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15825"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_4_3_1"/>
    <dbReference type="InParanoid" id="I4YGH0"/>
    <dbReference type="OMA" id="TIFMGVC"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="561" mass="61268" checksum="2BB58A2FF64DB704" modified="2012-09-05" version="1">MLKSFPNHSNFHRVIDFDDNNENTEELIALDQFAFKKGLSPRPSVESRRDSITNPLLNEEPSETLNGDELPKTTNNFEVDCIHNISYSLERHDFLLRLGRALMTYGAPTHRIESQLIATANYLDISASFLYLPNILLVTLSDYETHTCENFYIRSSGGLDLSRLSKTHKVYMNVVSGKMDAMEGSLRLREIVKSPDQYNAWQMVLIGASASAAVAPMAFSASLLDIPIVFILGAMLTFVKVSGVVKRESFGFILEISCACLIAMAARALYKTNYFCFQSVAASAIVLILPGWIIACGALELASRNIVSGSIRVVYALCYSMFLGFAISIGSDFISVLGPEADGDQNDQLDTVTLSGTFLPNSSLGDISNPMHEGSFTFTNTSAPAHKGNVVCIRHPDNPFYLKAMPKIYLLICAPAFATLLSMYNRADWRSKEMWIGVLISCSGYASNVATTMFTPDRSDIISSVSSFTVGFLGNAYSKMFKKSAFPVTVTGILLSVPSGISAAGGIAMSNPSPDNETSFSRGLVIGLRMFQTAVGIVVGLFLSTIFVYNIGARRGFLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGX7</accession>
    <name>I4YGX7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956611.1">
        <property type="nucleotide sequence ID" value="XM_006956549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGX7"/>
    <dbReference type="FunCoup" id="I4YGX7">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGX7"/>
    <dbReference type="GeneID" id="18473391"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59498"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_2_0_1"/>
    <dbReference type="InParanoid" id="I4YGX7"/>
    <dbReference type="OMA" id="YANMTEA"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="347" mass="40613" checksum="88044441064D0459" modified="2012-09-05" version="1">MANPPVDPTLDPPEESNDRLNEELSQFPDFSRSQANNEEEARQQSEKKSAEKKRHQKKRIQRRDESPEYDSSHQPPIEQEEDNSQFLEPSQQKRLDLHSKIDAIAKGNKNSRRKRKRTDEDLDAAADEELHNLREQMFQAAEEDEEYKKFNKPALNKLKLLPKVVETMQKTHLETSILENNFLDGVRRWLEPFSDKSLPPLNIQTEFFQILSNMYIDTQSLKSSKLGPVILFYSRHPRVNKSIKKAADALVTRWMRPLLRRSANPRSYQFSTNSNVVRTSDVNLTSREDNEEDYSNRTRIPELERKKYKVAATRGVDGIKSSNVTLSNQESERQRQLSRKFSMLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI1</accession>
    <name>I4YHI1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956799.1">
        <property type="nucleotide sequence ID" value="XM_006956737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI1"/>
    <dbReference type="STRING" id="671144.I4YHI1"/>
    <dbReference type="GeneID" id="18473450"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59604"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="I4YHI1"/>
    <dbReference type="OMA" id="HIAQKCL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="70"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="431" mass="48232" checksum="46B434E46F9C2B18" modified="2012-09-05" version="1">MDNYNRVAGRMGAFEKLMADIYDADKNPEGIINLGVAESGLMADELIEYYNTHFKLRGFDLTYGNSLGTSIELGNAMADFFNRILSPVKPIRRGDIVVGVGMSAVISQLSWYICERGEGMLIGAPYYNGFDADLTAQSQVVPVEVQFRDSVDPLSVTALEDFERVLLESEKKGTKIRALLVSSPQNPLGWIISRETLIAYGKFAQKYNIHFICDEIYALSTFKSKDVPSPPEFISAASINWEEHGVDPSRVHILVGASKDFASNGLRVGGLISQYNRDLISALATSAILMKLSSPSDILWRTLLADEKFMDWYIPENQRRLSDSYNFATDWCKRLGIPYEKACAGFFFLIDLRGYFPTRNAAGDILDSDEKRLQELSSRLVANKVLLNPGTSYHHRVLGMFRLTHTLYPSVQETGLARVEKTLKEIRSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ9</accession>
    <name>I4YHQ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="8">HIU hydrolase</shortName>
            <shortName evidence="8">HIUHase</shortName>
            <ecNumber evidence="8">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="8"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956179.1">
        <property type="nucleotide sequence ID" value="XM_006956117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ9"/>
    <dbReference type="FunCoup" id="I4YHQ9">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHQ9"/>
    <dbReference type="GeneID" id="18475214"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67165"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHQ9"/>
    <dbReference type="OMA" id="DADSHYH"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="112" mass="12947" checksum="6E5756FD1C9ECAC6" modified="2012-09-05" version="1">MSVNSQVTTHILDTSSGRPARDVAIELFTGQENDDYKSTTNEKGRCEDIIPNRSLSKGKYQLRFHTGEYWEKQGIRPFHPIIDVHFEIYDESEHYHIPLLITPASYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHR2</accession>
    <name>I4YHR2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956181.1">
        <property type="nucleotide sequence ID" value="XM_006956119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHR2"/>
    <dbReference type="FunCoup" id="I4YHR2">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHR2"/>
    <dbReference type="GeneID" id="18473241"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59238"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_1_1"/>
    <dbReference type="InParanoid" id="I4YHR2"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="43"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="37085" checksum="D44AB568363BDA6F" modified="2012-09-05" version="1">MKSTSTSDVEGIAKKVSTGVNENGDKSIDENKEKSPHKSYDGKKMMEWFIAGGASGVASRTAVSPIERLKILQQVQSFSKAEYTGLWSSLKKMYKEEGFKGFMRGNGINCLRIAPYSAVQFSTYEFLKILFAGDSNRPLENWQKLAAGALAGINSVATTYPLDLVRSRLSIATASLGVESSRQDAKLSMWAMGKKVYREEGGYRGLYRGLVPTSVGVAPYVAINFATYEMLKSYIPIDGSKWLALVIGAMSGTVSQTLTYPCDVLRRKMQVNGIRSDALGPKYNGSIDAIKQIVRAEGFKGLYRGIVANWMKVAPSIGVSFYTYELVKELLEPIEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS7</accession>
    <name>I4YHS7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_42674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956196.1">
        <property type="nucleotide sequence ID" value="XM_006956134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS7"/>
    <dbReference type="STRING" id="671144.I4YHS7"/>
    <dbReference type="GeneID" id="18472258"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42674"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="InParanoid" id="I4YHS7"/>
    <dbReference type="OMA" id="GWLIWRD"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="25126" checksum="1D17D1259D4A7EA6" modified="2012-09-05" version="1">MTEKPFPRVFLIRHGQTEWSQNGRHTGTSDIPLTERGAQIVKELGPRVVGEGKLIDPSQISKVFLSPRQRAKSTYELLFGEHKVTGEVVETNDAREWTYGDYEGLKPAEIKALNPNFWIWTDGCPNGESPEELTARADNLVKEIREVHRKHLEDRKNGVETQGSGDVVLVSHGHFSRVFIPRFLGFELQTLGPKLVVEAGAVQVLGYQHKNLDEPSIYAMNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHV6</accession>
    <name>I4YHV6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_67203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956225.1">
        <property type="nucleotide sequence ID" value="XM_006956163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHV6"/>
    <dbReference type="GeneID" id="18475221"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67203"/>
    <dbReference type="HOGENOM" id="CLU_537713_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHV6"/>
    <dbReference type="OMA" id="NEEMIPR"/>
    <dbReference type="OrthoDB" id="3355509at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="456" mass="49197" checksum="7CC8B9295076F089" modified="2012-09-05" version="1">MTDTPKQQQRTQQQNNEDIIPRKKVLGLLQFLGPPVGCKVFQHVSELATLPGLDLDSGMSRIAFMPIWLHVPADKEWDAEEICRTGLKLPQGGVGNKAPVLEEHLCKIGRPDIGIEHWYEMGDWVCSECRFLCWASKNECRECGARGNDPVNKSQVQTARPQQPPVRVALRNALCVEALDAFGKGETVMLISGGEKIETGTAASRRSPEADKKRIPITPVKVHSNIPPMPHSAPLPMRSGSGSSIGSAGGTSKPPATATAPNAPAPAAATVKPPPRITSTSPLPTSTSFDTTWMPTANSNTSILSENNGFLSRQRSRANNSRRNPPTPLLPIFASGWSQQERTLSPTPLKSSTGLLTPISSPISTTSENFNLADLHMDAQPIERRPSTSSTTVKPIGPPKQGFNMSLPSPPQSANSSPNKFDPFNDPKDIPTTPSEQDVEDALFKASTALVEFCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIC5</accession>
    <name>I4YIC5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_27184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956382.1">
        <property type="nucleotide sequence ID" value="XM_006956320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIC5"/>
    <dbReference type="GeneID" id="18470979"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27184"/>
    <dbReference type="eggNOG" id="ENOG502SFDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152505_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIC5"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27799" checksum="EF01AB5752EBD646" modified="2012-09-05" version="1">MENDGTKERLMENLQDVSKPSHSRKAKDNHVSRPRNSWIIFRNDIHNQLKSIPSWSGDIKYESRYASERWKAVPPEVKQTYIDLANQEKEAHQRAHPNYRYKTRRGATSKGSPPEVQEHQDISSISSSGSPYENSMLNQVPSSAHDNLTAAIAERYSKEHNSYHDEYKQNHNFYSTTTSFNLTTPPSVDPYNRSNYCQDNSDRPFRSFDGISTPNFEYHGDGLLIDTRYYADLPGSSSRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YID4</accession>
    <name>I4YID4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="18" type="ORF">WALSEDRAFT_31222</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956391.1">
        <property type="nucleotide sequence ID" value="XM_006956329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YID4"/>
    <dbReference type="FunCoup" id="I4YID4">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YID4"/>
    <dbReference type="GeneID" id="18471265"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31222"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="I4YID4"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="4"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="946" mass="105934" checksum="0F4D0B090376E724" modified="2012-09-05" version="1">MTEWTAKRVRSTYIDYFKQQHAHTFVPSSSSIPYEDPTLLFANAGMNQYKSIFLGTVDKNSQFGQLKRAVNSQKCVRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIEMAWKLLVDVYKLPADQLYVTYFEGDPKQGLEPDYEARDIWRSLGLPDDHILTGDATDNFWEMGATGPCGPCSEIHFDRIGGRNAAHIVNADDPNVIEIWNNVFMQFNREADGSLRPLPAKHIDTGLGFERLVSILQNKPSNYDTDVFTPIFEKIQQMTKARPYAGTLGAEDVDGIDTAYRVIADHVRTLTITISDGGVPNNVGRGYVLRRILRRGCRYARKKFGVPIGSFFSTLAPVVIEQMGDMFPEITKKYDDIKEILDEEEESFSRTLDRGEKLFDSYAQKTLNTPEKQLGGKEVWRLYDTYGFPVDLTVLMAEELGLTINMEEFEKARIESHEASKGTKKKGDVESVKFDVHDLAALEKDNIAKTDDIYKYTHGTVDAKIISIFQDRQFHKSTKDINTSKPFGILLDKTNFYAESGGQEYDTGMITIDGKADFAVEDVQVYSGYVLHSGALKYGELNLNDDVIATYDELRRWPIKNNHTGTHLLNFALKEVLGDHIDQKGSLVAPTKLRFDFNHKAGLSVAELNKVEDLCDQFIKRNVPVFSQEFNLDDARKIPGLRAVFGEVYPDPVRVVSVEFNPQDIKHDIENEKWSKSSIEFCGGTHVNTTGEIKLFKIVEESSIAKGIRRIIAVTADDAVEVMRKSSELANKLAFIDGLTDMKEKDIALKAYAVEIGQAEISTIRKIELREQYNKIRKTVDDANKAAQAAQAKYAGDTIKNYFNENEEAKSFVGTLDLGSNTKALGQALSAARQLGKQVYVFSVDKDASKVAHQCYIPKELLKDGYNAKIWAAKVAEILGGKAGGKDDSAQGVGSEVSKVEEAIGAAKSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE7</accession>
    <name>I4YIE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tricalbin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31231</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956404.1">
        <property type="nucleotide sequence ID" value="XM_006956342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE7"/>
    <dbReference type="GeneID" id="18471268"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31231"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427676_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIE7"/>
    <dbReference type="OMA" id="MQIEVIS"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="236"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="432"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="580"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="80172" checksum="91D7E5EA65CF7C5D" modified="2012-09-05" version="1">MVFGLKSKDHANTEQEGEANEAKYQQDVSELENELKQSEKAGGKVHTFDPNDDPSSKKKAAVKSGAAPDTGNKETEGTALDLDDEDNSVEMSATTTLDDAAKATNDAAEKGDAKEDELPAKSTEKTPDDDIPGKIPPWYKVGHKMSLTALDTNLNDDVELNRLATRFFGKWYMNSGVLILSMILTIVIGKFNLGFGWVLLVLAGASTFYNIHMVRMKRNIKDDISRELSINRLESQHESAEWVNSFLDRFWLIYEPVLSATIVSSVDQVLSQNTPGFLDSIRMTQFTLGNKAPDIEYVKTWPNAGNGLIQMDWRVAFKPSDKSNITPNEAKKQVNPKIVLAVRVGKGVVGKALPILLEDMNFSGYMRIKFTLDKDFPFIKLVGVSFLERPKFDYVLKPIGGDTFGFDVGNIPGLSAFITGQVHSNMGPMMYHPNEFTLNIKEILAGTPMDAAVGVIKVEINSARHLKTSKLGGGKPDPYVSFNIGANVDIDRTATIQNASEPSWNEVKYLLLTNLNDMLIMNVMDFNDHRKDSDIGMASFDLATLNEERNSKDSNAKIIYDGKEHGLLDYGIHFFPVLEPSKDEEGNVIPPPDLPSGVVRVSITQAQDLDSSGSIFNGNISPYAVLRVGKKQIHKTQTMKQTKNPNWGNNKEYLVKNKNKSMVSVEVFDDKDFATNTSLGTVTVSLTDLLTAKERQIDWFNLSNVKCGRIKIEATFKPIDFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ2</accession>
    <name>I4YIJ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956447.1">
        <property type="nucleotide sequence ID" value="XM_006956385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ2"/>
    <dbReference type="FunCoup" id="I4YIJ2">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="GeneID" id="18473338"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59411"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_7_1_1"/>
    <dbReference type="InParanoid" id="I4YIJ2"/>
    <dbReference type="OMA" id="VAVQTFH"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="340" mass="39631" checksum="C7CE292A9C7ECD25" modified="2012-09-05" version="1">MDKTRDNKSSATNTCGRIWISSVVFLISFLAFSMQFYSVYYTLRQLIILNLFAFLIFLNYYLCLSTDPGGVPTYYEPISLRDNVLEMKSNSDNARFCRSCQVYKPPRAHHCSRSNRCILRMDHYCPWMNNCIGFYNYGHFIRFLIFVDIGCLFHFYLLTKRVLNPIPPPDNTETLIIVLNYISCIFVLLVVGSFSVYHIYSTATNTTTIESWEKDKVNNLVNRGKIRDIKFPYRLSVYENICSVLGDRPILWLLPQRMKGDGLSFTVAADTGKWVDVHSRGRSIIREPKSRRRRHHIAHAALHFEDGSPVDTNISPDERKRGRKFENETLEFEKRLLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM8</accession>
    <name>I4YIM8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">WALSEDRAFT_67431</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956483.1">
        <property type="nucleotide sequence ID" value="XM_006956421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM8"/>
    <dbReference type="STRING" id="671144.I4YIM8"/>
    <dbReference type="GeneID" id="18475252"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67431"/>
    <dbReference type="eggNOG" id="ENOG502QSK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035539_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIM8"/>
    <dbReference type="OMA" id="WEVATTN"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697834" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="135"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EIM23820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="464" mass="51647" checksum="FE5D26C0CA387FAB" modified="2012-09-05" version="1">MFLRTGLFSLSLLGLSRSQNVPPTDAESAALIQDPIEECTSYNVPMVDEIKPNFPPIWEPAVIVEGDTAAQNKFNEIKQVLPSNIKPKGTHDGDFSKTLPSYDVSDPDCWYTFNKCTKPKVEGLSDDITNLPEPETWGLGFDDGPNCSHNKFYDFLSENELKANMYYIGSNVLNWPYQAQRGRSDGHQLCVHSWSHHHMTSFDDEGAFAELYYTIQAIKAVTGVTPTCWRPPFGDVDDRIRLIAESLGLETTLWEYDTKDWQTNFSQLDIDTVRQNYEDVFDAAKNGTFNDHGTIVLTHEITGNTMDLFMEMYPKIKENFKYVVPFYAATNTTNLYVETDEGVEQGETFEDYVNHVYGSTVSAPTSTNTNYHPEPTKTGWGGPLATVANPTVVSIESASESGSDEDDNVVNGQNDSDINRVSIEHKDSPNGKGDSSDNSKATHTSVTSLTAIVALFVISTSFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIU1</accession>
    <name>I4YIU1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_58991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955727.1">
        <property type="nucleotide sequence ID" value="XM_006955665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIU1"/>
    <dbReference type="FunCoup" id="I4YIU1">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIU1"/>
    <dbReference type="GeneID" id="18473110"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58991"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIU1"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="37014" checksum="8B8430BF3ECCEB51" modified="2012-09-05" version="1">MARDRLAALRAQQNANGGSYDQMQHSYSTPQYEMDDVSIKNVSTIGDMSAFFNKISDIQSSLTNLQGNINQISQLHNQSLNNMDELAQNRVHAELDSLVSHTSKLTNKIKTEIKSLEKENASGQVPSNDLNVRRTQIASVKGKFLETIQDYQKVEQNSRTKQKQRIERQYRIVKPDASPDEIEQAVDSPDNQIFSQALLQSNRYGDAKSAYREVQDRHQDIKKIERTLTELAQLFNDMSILVEQQDETLQNIHASAEETNKDMELGLIQTERAVKSARAARRKRWICFWITIVVLAIIAVVLGCGIYFGAVRPAQRNEGPVASASSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ67</accession>
    <name>I4YJ67_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tim17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_34528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955843.1">
        <property type="nucleotide sequence ID" value="XM_006955781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ67"/>
    <dbReference type="FunCoup" id="I4YJ67">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ67"/>
    <dbReference type="GeneID" id="18471869"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34528"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063935_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ67"/>
    <dbReference type="OMA" id="FQPTPFD"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="211" mass="22165" checksum="96127F8E0C294DAF" modified="2012-09-05" version="1">MWPFTSNTEKSEGTNVQNIEQNTTTTNDPTSNLSASSAQDVLSIDPTTLHPMADVGDKLDYLLLDDDKLSELPGSETALPSRGWTDDLCYGVGTTYVSGLGIGGLWGIREGMNKKLAAPVTRLRINAILNSVTKRGSFIGNSGGVLALVYNISNSSLDSIRGKHDVLNSMGAGAISGALFKSTAGLRPMAISAGILASSAGGWTLFKRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA4</accession>
    <name>I4YJA4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_55913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955876.1">
        <property type="nucleotide sequence ID" value="XM_006955814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA4"/>
    <dbReference type="STRING" id="671144.I4YJA4"/>
    <dbReference type="GeneID" id="18472752"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55913"/>
    <dbReference type="eggNOG" id="ENOG502SBXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023004_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJA4"/>
    <dbReference type="OMA" id="REGMPYK"/>
    <dbReference type="OrthoDB" id="5964929at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="564" mass="62090" checksum="F2140FF3001024C8" modified="2012-09-05" version="1">MTEPSREILSNSAALNSLKRPQLNRLCKRFGVNAKGKNSELIERLESLASSISKEQLDDYAGAPEESPVKKARTTEPWELIEGVSQSEDIDFNPPSPSKQSSYNSSTQSKSIMRSIGSSIKSKLKEFSPSKQSTVSPSKYQDVVVEMKQDDSSGDESEDEQSQSWNVVPGECQPTRLSTAASIHEDTIVDDTVKLVGNEREPSPSPSFVNRPSLPSQESNTPNKIYPPLPQFVFGQSSVSNAGFTNVMEELNKRLPSAEIKPEIKEQFENANTRKSASELGLKSGTNLKIKRKFDDAHKNEFDKMDSIANHYSARPKISPRKTTSVESPRKVNARPSSGETSQPNKRIRVAAPTQEERERRDDVKRRLELSRQKRRSSMAANARGIPTARPSVGRASVKPPTRIGSASRAAGLIKNVGKKLFGGSANESEKTTNAEPSTSSTTDQKQPKRVVRKLKKPQEVSTRTTSLTKPAPFKFATEKPKPVVAGPSKAAAEPSAQATEAQQRAAERVKMARLKESNKGGKSMTPRRKTNVGSKRPSNAEQVSKARLSQSPIKRRQTRERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJH7</accession>
    <name>I4YJH7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955945.1">
        <property type="nucleotide sequence ID" value="XM_006955883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJH7"/>
    <dbReference type="FunCoup" id="I4YJH7">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJH7"/>
    <dbReference type="GeneID" id="18473174"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59100"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161923_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJH7"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="239" mass="26959" checksum="6DACB53BBB90E688" modified="2012-09-05" version="1">MVYVGQSGVDTALKSWLQVSVDTLFTAYRCESSNNNEVHIEVSMEQLYRAIKSAHETDDVLLRLMKKGAIPTLNLSISTLSHYNSRFTIEQDVPCRPQKQIYVDTFDQPAIPERNVTVQLPSIPKLKTVLEKLRILDNYVTIRANWEGKLEFSILNDQVGVRTTFEKLGVQSNEGARGTVVVDSRQLIKVFQVPELSNRAFIGICNNNCMAFYGFLESLSPSSEGKDDYLMFVIPSKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK9</accession>
    <name>I4YJK9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955975.1">
        <property type="nucleotide sequence ID" value="XM_006955913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK9"/>
    <dbReference type="GeneID" id="18471203"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30880"/>
    <dbReference type="HOGENOM" id="CLU_2795881_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJK9"/>
    <dbReference type="OMA" id="SMNDPKM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="69" mass="7062" checksum="3EAEFEA1117813E8" modified="2012-09-05" version="1">MSGGPKQATFGGSEPRAANEVEKQAQDIQRQNETNKGGAAGREGVASTNPSDYDRRGGSGGGSLNDPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJN0</accession>
    <name>I4YJN0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955993.1">
        <property type="nucleotide sequence ID" value="XM_006955931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJN0"/>
    <dbReference type="FunCoup" id="I4YJN0">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJN0"/>
    <dbReference type="GeneID" id="18474701"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61999"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_4_1_1"/>
    <dbReference type="InParanoid" id="I4YJN0"/>
    <dbReference type="OMA" id="GFECDDV"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14490" checksum="94E964A44100D205" modified="2012-09-05" version="1">MSQQQQHTENDKQKEAQLKHDKKLSEFLGLLETNEPLIPDQVTDHYLNKAGFECNDPRLKRLFALASQKFISDIANDAYQYARIRTTAGPGGRGRPTGTSKSKTVLTSDDLTAALSDYGINARKPDYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJP4</accession>
    <name>I4YJP4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_34786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956006.1">
        <property type="nucleotide sequence ID" value="XM_006955944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJP4"/>
    <dbReference type="STRING" id="671144.I4YJP4"/>
    <dbReference type="GeneID" id="18471882"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34786"/>
    <dbReference type="HOGENOM" id="CLU_188587_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJP4"/>
    <dbReference type="OMA" id="HRVRWAR"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="10516" checksum="F51750B0E6DCAA17" modified="2012-09-05" version="1">MVGGDCLCCRDFWNSVGQDTAQEHKNRSSKHRSHWPRPKTPPGYWDVDFPSTQKIALNKEQARQMHKEKREWAAAEANKDNGRHLRRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJQ2</accession>
    <name>I4YJQ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">cta3</name>
        <name evidence="26" type="ORF">WALSEDRAFT_53229</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956013.1">
        <property type="nucleotide sequence ID" value="XM_006955951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJQ2"/>
    <dbReference type="FunCoup" id="I4YJQ2">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJQ2"/>
    <dbReference type="GeneID" id="18472607"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53229"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="InParanoid" id="I4YJQ2"/>
    <dbReference type="OMA" id="DWPSGGM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EIM24194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110533" checksum="93EE98E7F99E70D2" modified="2012-09-05" version="1">MLGQSFERVEQLQNEFGPNRLKPPPKPSLWRIFGRQIGNAMTLVLIAAMAVSFGTQDWIEAGVIAALVILNVTVGFTQEWKAEKTVAALESVGSPVAVVVRHDPSNKGREGKILEVQTDEVVPGDIMIVKIGDVIPADGRVIDNHISNLEVDEALLTGESLPVAKAAETLQDKTCPVGDRINMVFSGSQVTKGRARCVVTSIGMATELGAISEALATKADSKKRGWKRHWEKFQVFLGVKGTTPLQIKLNKLAYLLLALAIIFAIVVVSSTGYKDIPDSTATYAVATAISVLPASLIAVVSLTLATSSRELAKRNALVRKMDAIETLAGVTDICSDKTGTITVGRMVLKKAWVPSMSEKVDTEVGQIYSVESGKDPYYPRGTIQALDENTVEEDESANSDSDAVQVNDLDPSFQDLVQSAALNNMATISAGEEGSEWDANGDPTEIALQVFAHKAGHGKPHLTHPPKHRAKKDHHPSPRAEVEGHFEMIIEHPFDSSIKRMSTAWKFVDTKGDDGSKQHVYIYMKGAVERVLERCTHVSMGDKAIEMTEEAKDNILKKMDELAAEGLRVLALAGKTDKLSNAQAVKETKRDELEKGFGLVGLVGIFDPPRPESKGAVYDSRRASIVVRMLTGDHAATAASIAMSVGILDKNHSKSAVMTGQEFDAMSDEAIDELDELPVVVARCAPETKTRFVDALHRRKRLTVMTGDGVNDSPALKRADVGVAMGLNGSDVAKGAADIVLADDNFSTCVRAVRKGRSVFTNLSKFLVYLLAGNVAEVLVLLIGLAIRSDGNAVYPISPVGALVINTLTIGPVAFALGIEPTADDTMLQPPSNFFSIFTPTWFLDLFSYGFVSGAITFANYVIVIYGRYDGNEDVSANCNEGEVTGECQVIYRARAAAYASLLLMLMVLAFGCKHTTRSVFQMNLLDNKLLIWSAGLLSLSVFPVIYIPVIKDRVFQVTGIGWEWGMIAASVLIFIAYIEGYKALRRWFIRRSSKKEDLESSTDREIRLAPTMEPNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJR1</accession>
    <name>I4YJR1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_30910</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956022.1">
        <property type="nucleotide sequence ID" value="XM_006955960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJR1"/>
    <dbReference type="FunCoup" id="I4YJR1">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJR1"/>
    <dbReference type="MEROPS" id="S08.070"/>
    <dbReference type="GeneID" id="18471208"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30910"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJR1"/>
    <dbReference type="OMA" id="RCCGEIA"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697769" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="17"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="454"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="607"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="716"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM24203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="822" mass="91394" checksum="28424B615393D514" modified="2012-09-05" version="1">MKLSLLPLIACTLAYSIKNPVEKNYESHDYYVLQSHIDSSEIEIAAIEELFGMEFVENVGELDNHHLFKIPKGHSFLIDDFHSHLHKRNNNQFRSITQQTPRHKLHKRAPVLPITESRIVAAALDINDPIFSDQWHLVNDKKSEHSINVAPVWSQGIKGQGVKVAVVDDGLDMHSKDLAPTFFAEGSWDFNDHTALPEPRLREDSHGTRCAGEIAAARNDVCGVGVAYEAQVAGIRILSTPISDADEATALNYGYQLNDIYSCSWGPPDDGRSVEAPSDLIAKAFVNGVQRGRSGKGSLFVFASGNGAASDDQCNFDGYTNSIYSITVAAISREGLHPYYSEACTANLVVTYSSGNGGTIHTTDVGTNTCTDRHGGTSAAAPIAAGIYALVLQVRPDLTWRDLQHLSVQTAEPINLEEDGWAVTAAGRMYNNAYGYGKLNTEKIVEAARNHQLVKPQAWYEGPIVHVPNATDMIGQPLSENWYESKFHLSEKRMRQHNLERLEHITTTVWIDHERRGDIEVELISPNNVKSVLAKVRRYDGAAEGLNGWKFMSTKHWDENPVGDWTIRVKDGFHPTKHGNFTAWSIGFWGEAEDASKAVDYVLPFERPKGELEDDDDDDDDDETLSTGTPSHSTSSPPTHQKPKPTDHLPDDHHQAGEEVPETSYTPTPDEGYLENSSFLLNHQTWLIGAAILGLAVVGATGTIWFIRRKKAQELARADEDSRGVYASLNPGGNDSHRMTEFPSNNGGRTRELYDAFKLADSDSEEEEEAENQDEHEYRDDDEENDNNEGDESQVLFDNDNDNGNGNDNHDETSPWDDHEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJR3</accession>
    <name>I4YJR3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_34831</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956024.1">
        <property type="nucleotide sequence ID" value="XM_006955962.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YJR3">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJR3"/>
    <dbReference type="GeneID" id="18471886"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34831"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="InParanoid" id="I4YJR3"/>
    <dbReference type="OMA" id="LYVWESG"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056890">
        <property type="entry name" value="UBA_DHX29-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24899">
        <property type="entry name" value="UBA_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="568"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="853"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="788"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM24205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1377" mass="154308" checksum="F818623FC47C5747" modified="2012-09-05" version="1">MPKKRSLKPVNRGFATTSVQKKVEEPKAVEDTPSTPAPPSRPATPPSTSQQAIEDDNVQQFYLKVLKDVERNIKSIDYDRKLAKQLPSLEIDNINYQELQPSFSSDDTENTEKLFIKLGITYNTLKRLGFSHDSIISAFNSTNSFDLQNALVWLALNIPDDELNTTAYTTIPPSPPKPLPMPSPASASSPKKTPSSASTSTTPSKQSKPSQPIPQIALSDDDQLDPTNAYVRFKLQLDDAERAAGIVKKKKKSKTDDCSDPQVIALRAIVEELQGMYLFDKKEADNAYKEHRSELDKQLLQERLKQPQQPQGLPAEEKEKEKEKEKPTTPPADESVGDLFKEEEQEELTTDGKPMPVVEMTLPRQISARSMPRTIVEETTLKIDKSAQSYFQVISKGSRAVRASGLIQWGVEYQYARDEYEMIDIGCQNDIQAINYTALILLHAVYLKHPAACTFKPSQFPASFQNLWNELEEKRKVIEITRQSEEYKMLKQYFDEKMEATPSKSRSTPRPTKTVGMDVESPLSKAEGTQVDTKLQKDFEKRQQTDAYQTMLQARNALPIAAYRQTILDTIDSSQVMVLSGETGCGKSTQLPAFILEDALSKGQKCKIYCTEPRRISAISLGSRVSVELGEKPGMVGGPESLVGYAVRLESHIGKSTKLVYATNGIALRMLESSNGTDGKSAFDDLTHIIIDEVHERSIESDFLLIVLKSLLQQHKNLKVILMSATVDSEKISAYFGGCPVISVPGRTFPVEVRYLEDAIEFSGFKVDETSPYARNRYDKIANKGKSQLTEWNDDDDDDENNSGTSTPKDQSITPTLPKISEETFATLNHLNEYLIPYDLIVKTLERLCTDGQWIQYSNATLIFMSGMAEIRRMNDMLQEHPLFGDAAQFSIYPLHSSIATDKQGAVFDIPPPGVRKIVIATNIAETGITIPDVTCVIDTGRHREMRFDEKRQISRLLDCFIAKSNAKQRRGRAGRVREGLCFHLFTRDRFENKLSDHPLPEMTRLSLQDLALRIKIMNVQIGSSIEDVLMRALDPPTSINVQRAISSLIEVKALRSNEDITPMGRILSRLPVDVHIGKFLLFAVVFGCLDSALTIAATLNSKSPFVTPFGQEVEAMNAKKAYNDGNSDFVVIVKAYNGWKQALQNQGWAFMKRYCDQNYLSLQNLQSIEELRIQLMSYLVDANFVTLNPKQIRELNAARMVRTGRGSIRFFETPEDLNHNAGDYSILHAAIAAGLFPKLISLDWHTKTMKTIQNNAIVSIHPSSPNSKIRWQEFGSSFLCYFTLLQSKKLYAHEVAPIDIMALALMCGDLDLKIASNTVQIHNKVKIHLDLRTCAVIACLREGAQAAINAKIRGKEWSSYQNHTFGIALDVLKGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJS2</accession>
    <name>I4YJS2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_42429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956032.1">
        <property type="nucleotide sequence ID" value="XM_006955970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJS2"/>
    <dbReference type="FunCoup" id="I4YJS2">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJS2"/>
    <dbReference type="GeneID" id="18472252"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42429"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_1_3_1"/>
    <dbReference type="InParanoid" id="I4YJS2"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="347" mass="39218" checksum="B89CD49CEB6D3D93" modified="2012-09-05" version="1">MESEGKQPTSIILLGMAGSGKSTVLQRLNSYLHSQKKPPYVINLDPAVRQLNYSANIDIRDTVDYSKVMKQYNLGPNGGIITSLNLFTTKFDQVLGLIEKRKSEVDHILIDTPGQIEIFTWSASGAIITDAIASEVPTVIGFVVDTPRTMAPATFMSNMLYACSILYKTRLPVLLIFNKTDAQDHSFATEWMTDFESFQAALSNRNATSTYNSSNLNEEPSYMNSLMNSMSLVLEEFYSNIKTVGISAMTGAGMQEFFEAVDECREEYYKDYKPELERLRKERQEKSEERKKDSLNRLIKDMKTNDEEPIESDASEEEGETLDAQDMKERGINISNNYDDGTSWPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJU4</accession>
    <name>I4YJU4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_30940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956054.1">
        <property type="nucleotide sequence ID" value="XM_006955992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJU4"/>
    <dbReference type="FunCoup" id="I4YJU4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="GeneID" id="18471214"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30940"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="I4YJU4"/>
    <dbReference type="OMA" id="NEVIFMM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="326" mass="36516" checksum="5B65BDE7925DF6E7" modified="2012-09-05" version="1">MLDCILSKVLPKSAYNFYTQSFPPASKWSTEDIPDLTGKTVIVTGATSGIGKDTARALMQHNADVYIGGRSDDKLNAAIDELKVQTGKTAKPFFVDLSDFESVKSAAEDFLKKETKLAILFNNAGVMVAPIDMFGKQGYDIQFQTNVMSHYLLTRLLFPALDNYSKTGETARVVHTSSLMQALTKHPRGIDFDVLRDGEKRRSNRKLDPWELYGYSKIGNTVISNILNEEQPNVSHSSCHPGGLQTELQRYVDFPAWKTAIFNLMLYPSHLGALTQLYLGTVTKDTKGIYGIPWAREGKADKRTDDPSLIKDLREWLHEELKAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK23</accession>
    <name>I4YK23_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_13933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955656.1">
        <property type="nucleotide sequence ID" value="XM_006955594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK23"/>
    <dbReference type="FunCoup" id="I4YK23">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK23"/>
    <dbReference type="GeneID" id="18470620"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13933"/>
    <dbReference type="eggNOG" id="KOG3015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047893_1_0_1"/>
    <dbReference type="InParanoid" id="I4YK23"/>
    <dbReference type="OMA" id="WDPVLHW"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="33638" checksum="9793B22D47AEC2CA" modified="2012-09-05" version="1">MLLRKISNNSFISKSIGRPRFNSLLSEAVAEITDVAAKSQAAGGWIQNLTPILIHYTAAERTMKRFWKTANVSNSNGRHIVHLDTRKLRTPAGNVIDLPSNKGALALLIAHEWQSQDKVIKAHALPITSLASRALDSFKDQSERIETCDKLIKYFETDATCYFEDKPSQLVELQEKHWRPIVEWANKRYNTPIHVFENVLASKQPEESRKLLHNEILQFDAFTLAAFERIVMHTKSFLIALAVVDGHLSIEDASQAARVEVLSQIARWGEVEDSHDVDHHDIRKQIGSAACTLIESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y525</accession>
    <name>I4Y525_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_49586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668263">
        <property type="protein sequence ID" value="EIM19067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960887.1">
        <property type="nucleotide sequence ID" value="XM_006960825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y525"/>
    <dbReference type="STRING" id="671144.I4Y525"/>
    <dbReference type="GeneID" id="18472501"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49586"/>
    <dbReference type="eggNOG" id="ENOG502S3YT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_9_0_1"/>
    <dbReference type="InParanoid" id="I4Y525"/>
    <dbReference type="OMA" id="HFEASRN"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="15789" checksum="4D2866025BEC745F" modified="2012-09-05" version="1">MIKVGVGCFILNKNNQILIGRRLNSIGHGTLALPGGHLEYGESFEQCAAREVEEETSLKLDNWRFGTAVSSMTESQHYVTIFMCAKHNTDVAPVTTEPQKCEGWSWINWEDLKKIPSDQLFKPLNILFQERENFTPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y552</accession>
    <name>I4Y552_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960850.1">
        <property type="nucleotide sequence ID" value="XM_006960788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y552"/>
    <dbReference type="FunCoup" id="I4Y552">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y552"/>
    <dbReference type="GeneID" id="18474651"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61636"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y552"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="177" mass="19877" checksum="44D9A0A3B15EDDB3" modified="2012-09-05" version="1">MQHPQLRWAQRSSETEAEKNLLFITINLSDIEGTPKLNLSSEKLEFEAKSNGEKYGFDIELFDKVQDKPVKVNQTGKGLSLTLLKSTPKAEYWPRLQKEKTKLPYVTVDWSKWVDEDEQEDAVEEGNPMEGLDMSGMGGMGGMGGNQMDLQAMMQQLGQNTGGDQPDEESDDEENTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y555</accession>
    <name>I4Y555_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_49520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960853.1">
        <property type="nucleotide sequence ID" value="XM_006960791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y555"/>
    <dbReference type="FunCoup" id="I4Y555">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y555"/>
    <dbReference type="GeneID" id="18472499"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49520"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y555"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17055">
        <property type="entry name" value="Ubl_AtNPL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="649" mass="72834" checksum="CE303024A6EA7CBB" modified="2012-09-05" version="1">MIVRIRSADGTFRFDLKADDTIELLKDNIVDKAPSLDKDTLALSNEPRGGETLLSSLSGRKLSDLGIKHGDLLFASSAKKDEETVEQSQPQIQQTSNIPARPWQLARDHAIDQYWSKQSGRIPRPTSSSKEGNLNTLPIEPYDKEYQAQNNIKHLSFHAYLRKLKDNNPPTSSVAQLPPLEELDYKYKQWVPNAITLQVQEYRMVDHVEFASSGLVEGLLNFWRASGLQRFGLLLGKYAPYDAVPMGIKAVVESVHEIPQEGEVDGLTLGLPWEDQERIVDLAKSAGLEVLGMIYSDLSQPPEAQSPLCKRHKDSFFLSSLELCFSGHMQNAHKLSSTQSKSGQFNSRFITCVLSGTAEGGIDISAYQISDQGMALVDADIIEPSVEPSTLRLKESKPGKYIPDVFYRFKNEYNIEVKKNARPCFPVEYLLVNVTHGFPNQSNPTFKRNNFPIENRQGYQDQSVNKMVGLFLPVVSDSKGLGFDNSEDLDLGATSIEKKETLYDTLNDWHLCAFLEPSGMFSRDEAKLALRIGINREEKDLNNFIRSPSWLNLMAIAREQASAQAASSNAQFDAEDIPHDVLAASEQTARQEREQREQEQRDVDVSPEDREAIENLCAFGGFDFEQAKQCYLACEKNTEMAANLLFESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F8</accession>
    <name>I4Y5F8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_61595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960772.1">
        <property type="nucleotide sequence ID" value="XM_006960710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F8"/>
    <dbReference type="FunCoup" id="I4Y5F8">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5F8"/>
    <dbReference type="GeneID" id="18474627"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61595"/>
    <dbReference type="eggNOG" id="KOG2762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035382_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y5F8"/>
    <dbReference type="OMA" id="PERYGIH"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="403" mass="45902" checksum="C3A4284052BCB139" modified="2012-09-05" version="1">MSSFDKARKWMWETIFTNKGLGLACAGVIALESILTPLIVKYVPYTEIDWKAYMQQVKMFREGSITHYDQIEGDTGPLVYPAAHVYSYTALYHLTNAGTDIELAQYIFTGIYLLTLTLILGIYCKTEAIPPYILPLLALSKRLHSIYVLRLFNDGIGMCIFYASLLALIYRRHLLSAVLFSLAVGVKMNVLLFLPAYALIYTLQSGLFGCLRLGINMLTIQVLLARPFLRTDSKAYVSRAFNLGRQFLFKWTVNWRFIREDIFFSKSFAWSLLGVHAVLLLSFALFKWLPRDGVTALEVIKHTLKYPSRRPTARLLNAKEISQIVFTCNLIGIICARSLHYQFYSWYAHQIPFLAYTTRYPLVFKIALCVAIEYAWNVFPSTDISSSVLLASNVLLLAGQAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G4</accession>
    <name>I4Y5G4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960703.1">
        <property type="nucleotide sequence ID" value="XM_006960641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G4"/>
    <dbReference type="GeneID" id="18471152"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30525"/>
    <dbReference type="HOGENOM" id="CLU_994668_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5G4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697524" evidence="1">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31006" checksum="B0F10A7D9B9331F7" modified="2012-09-05" version="1">MARLSFITLTCIIFGAMAYRASTDMVTLGGSGFVGGIFFIVEKCSRDNGGLTGDQCARAILIDLFFGIIYGIGCIALKLIPTSLASFESGLDISHTVLGNVTHLDFMSTADNPDTPQDDVRSFNNPNVFHILKLFNDKDDGASYPAVMHRFIPELNSYQVQSTTHLNGSGSKRQQSNNDRWVFSYAVNRQYFGENTRHYPNIPNWVVEQMANDLLGRLYELDADNICINFNGEFGLWGKLQVANADTAGGIGASQCDPYYNNDYAGGGHWTYNYQVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-09-13" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H8</accession>
    <name>I4Y5H8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_41599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960717.1">
        <property type="nucleotide sequence ID" value="XM_006960655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H8"/>
    <dbReference type="GeneID" id="18472218"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41599"/>
    <dbReference type="HOGENOM" id="CLU_1801184_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5H8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16035" checksum="0A210B5F8527F22F" modified="2012-09-05" version="1" fragment="single">MTLPALELKQINLKLKCLNDSKLSSSPNSAVLTPAGFILIASVDSVYCLPLMEIDKQPRILLKKLKDCHSIRILPLTSVILLSVEKSARYYDLRQVDQTCLKIWDISTKHLNVLPDLRTPAPPALELNYELAPPTPTTPPFTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I4</accession>
    <name>I4Y5I4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960723.1">
        <property type="nucleotide sequence ID" value="XM_006960661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I4"/>
    <dbReference type="STRING" id="671144.I4Y5I4"/>
    <dbReference type="TCDB" id="1.A.101.3.1">
        <property type="family name" value="the peroxisomal pore-forming pex11 (pex11) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18474612"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61573"/>
    <dbReference type="eggNOG" id="ENOG502S8TV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059609_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5I4"/>
    <dbReference type="OMA" id="YSIRVYL"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35754" checksum="3052F64C73309032" modified="2012-09-05" version="1">MVRTPSYLPTTPWIEQAQRYGIPLSNTGKLLHAAMPNRMKVSTSQIIDRLLATDAGRDKIFKIIQYAIKLFLWRSKSNPNLSIQAKDWLPYLKNCASGLSTTRKCLILFAWKRTIPDLYQLLKAPKQPAGNFLDALKGRLTLISAIVQIPNSIADDFFCASKLGLVGSKTGKLAEKYGALFWWTDTFLQLNISAINEIVTNGQIRKLQSRQDHLQQCLEDMSEDKLSNKVEYSLSDETLGAFLRIDADIRKAESTQMWARLSALKYVCDFIFVSYDVFGFKKGQEGTQAIVGLTAGLLSTLKLWDKHYTSLSKVPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y639</accession>
    <name>I4Y639_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960581.1">
        <property type="nucleotide sequence ID" value="XM_006960519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y639"/>
    <dbReference type="GeneID" id="18475113"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66412"/>
    <dbReference type="HOGENOM" id="CLU_2499613_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y639"/>
    <dbReference type="OMA" id="SIGHEYI"/>
    <dbReference type="OrthoDB" id="3344936at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="86" mass="9669" checksum="1B199E30232B48DD" modified="2012-09-05" version="1">MSHSLEANNHNILEEAVNVAKRASFDSNSLSHLESLASERAQLVHKHRELHDDDAEQDVTSVHLYGQRARGLSIGHDYEHRKSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y647</accession>
    <name>I4Y647_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_30345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960471.1">
        <property type="nucleotide sequence ID" value="XM_006960409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y647"/>
    <dbReference type="STRING" id="671144.I4Y647"/>
    <dbReference type="GeneID" id="18471145"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30345"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070400_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y647"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="260" mass="29234" checksum="EE97CD3E573BDD28" modified="2012-09-05" version="1">MASSSITVKLVLIGESGAGKTSLRNQYLHNRFNNYYKSTIGADFYSKKIQVGSTQVNLMIWDTAGQERFASLSNAFIRGADACLLVFDATKAPNLETLRHWFETFRSNSPVFDNDLNDFCLTAIGNKIDAIDCNSFNSEDYLDTIKFLHPNSNQFKSPRGVISSTPKAIPNRMFNEDSNDQFISSNNTNTRNTIYYTPSSSFDTPSTIEPSPIRLNSQNDNDRNENTDSDDYNINDNDYGFKLFWTSAKTGDGVDQVFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6S0</accession>
    <name>I4Y6S0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_33920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
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        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="85" mass="9809" checksum="684DC1BB3496511B" modified="2012-09-05" version="1" fragment="single">MKIDQTTPSNEDTVNAENIYKKRHKRLFNVLIKSISTDILNRIDETNNASAFFQDISLATDLNTMKRHYLDNSDGLSYDDLTNKI</sequence>
</entry>
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                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
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                <person name="Furukawa K."/>
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                <person name="LaButti K."/>
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                <person name="Grigoriev I.V."/>
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            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
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                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000005242">
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="97" mass="10632" checksum="5C448B1E44C18185" modified="2012-09-05" version="1">MIPTVSAFEAYNLIYGGSKVASQTSPQILAQAASYKSMKAFDALATKPGDKYASRTLLSAISKKEVDELERKYRMSPQQLEDTRKLARLSAMAIIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y725</accession>
    <name>I4Y725_WALMC</name>
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        <recommendedName>
            <fullName evidence="3">DUF7727 domain-containing protein</fullName>
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    <organism evidence="4 5">
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            <taxon>Wallemiomycetes</taxon>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
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                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EIM19767.1"/>
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    <dbReference type="KEGG" id="wse:WALSEDRAFT_58506"/>
    <dbReference type="eggNOG" id="ENOG502S16N">
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    </dbReference>
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    <dbReference type="OMA" id="MRASKWG"/>
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    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="3">
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        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1269"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24853"/>
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    </evidence>
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            <dbReference type="EMBL" id="EIM19767.1"/>
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        </source>
    </evidence>
    <sequence length="1317" mass="146571" checksum="66CB14F041809F9B" modified="2012-09-05" version="1">MSSIQETSAEFKLARLLALVASAWGLVYRKFFLDMLGANLGPTGIIPNINISGLIFITETIALLQILIELLSLFSLMLNYPIKFFSGFKQHKLRIGVLYFTGTLALGVYQAVDGGVYMLISATIYQVLLYIHKPPRDTSDSSIVIRYGPEVTQSIKNKPKADYIHFKSNTILDNTRVNASLDDTKNVANCLDMASCPFAEVYNLSLDDQHDIKRRQNFDDGKYHGVGSLSGSRDSTTPPDAQVLPNDADSSTINSKSTSNVNSDKKLKSSSSSDNVEIENIEDEDDLEDDITTDSDGDDNDIEKDEEIEIPDAEDDSDLSDDRPDSTIPPSNSNDDEATASISDTSPDFKVAYLSPIFIIGGLVALFTIVGLIYRRRRRNRLAREREMALENGSSEDMDSHLSKSVEANVFSGNLEEEPRHSSWQTNDDAEMMSPNTQAFIQASNARLDRPWTYQPSGLSPQSFRNEPWKWPSNHTPKDVSKPLYHHTNSSFQPPSQITDEFLKSPLPEGYQDASPEDIDRNFVEMGDRKKYNSGSMAFYSNAMKSVFDGERKKSGSIGKKFLSRKATAEMDNGQGPQIRQRKVSDKQAQQISENDDNNFISSAFSPPLRSSTPWWEISQAVKTVFNPPKREPTPAFGGFFKRSSTPANPLVKEMQTLNQNESEPSEENVLTPISKDIKSPVPISYDQIKSESNSTDETQKMEMPPPPLPKSPNKKVKREKKKSKSNKHTFSPTSPIVMNAVMDQNIDLTSQHKLEKGKEKIPHSPLLEQLARSPVPLSPKFAELSNRDENSDFEEDGPEMNDDNAHSQFYTVKDMKNIRDEFSDEAAKLREMAITPFVKGQGSTTKGISEVVSSNMKESQSQLTPPGLCPETQVQSPQQQDATLSQLPFAQSPQLGGKKTHPPSWSLEAQVPRVVSPPPNAISPPLVSDWHNLPETLRSPPPQAVRSEMIFQANANQAGHQSITAALTKEFENQNKNEDVGSEVKLEDEPEVETWSEGSGSTVFYEDETYQDDGIINIGRSNTSTKVSSQPGSVGAASTRSKIRRYKTRRSAMSTSTRYRNSQTSAPNNFEENSKVSPNNNEQQRMVVDDWKKVESNRNNVSASTEVHAVERNVKESPIDEQFASPLNEVNESPKRSDDDFKSPKSDDFKSSKSNTSVMKSPLSSDFLPTIEATPELARSSTMKNYLMRLPSIKQATGMGSIDMNAMANDRLPSPAYNSYESGNYKYNFIGKGQGNLESPQYSSLNDQDDSNKALAKVDEILTSSWSSRISSDDLEEAPPRRRGAAVAPRTRKLLEARMRRERSESPTSSIAENEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B3</accession>
    <name>I4Y7B3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959998.1">
        <property type="nucleotide sequence ID" value="XM_006959936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B3"/>
    <dbReference type="FunCoup" id="I4Y7B3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7B3"/>
    <dbReference type="GeneID" id="18474403"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61225"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306339_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7B3"/>
    <dbReference type="OMA" id="DRKHRKF"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="629"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="967" mass="110893" checksum="C151856C7EA064B6" modified="2012-09-05" version="1">MDDQFKRPTAGKKRSLDVQQSTSKRPKVDKPEKHIEDYMKKWIKAFKNIVLHFDKPEDIALKNEIIFMSRILGARVENFFSRKVTHVITSRQISKDSSVVKSPPTEKENQPKLNRQATPTYGEQTVVKSNYVMFDSNNQRTQSIVDTQPKNPFLDGSQQNDLLLKAQEFKMKVWSFGKIYNMLDFIFGNSPELKSVYKNLKSDRRARKEQEVTLKALLTKEKLQGTTERDRSVRTQDFYYFHRNIKYILVEDTESIYRPILIQEYAQPRSHEEPSWPILFACRDERNPFQKYYQNETPFDGKCFASRNWGMREHVNYILEAQLSRLVKQGVITMESPVQKDEEEQAEDPPEAGKAEEDDAYVAASGNSVTITSNTATSQAASRHMQHRDKRVSQFDRRITEHRPKTAHPRASLEIPPSSSKYIVQQSLGKASDASPAASTSRRVSEQSANTSLEQRRGSKSKPIVENGATPTNAAQALLRAREHSIHLPQESVVRRKSNDKFEEHVNALKNRSGEVSKERRVSGSKDVQESPPPKEILATKEARAAFKEVVPKRDIPKKENTIIEKPKPEETAKLTNEFKEPVKPSQPAKASKEEPETSISKETATLYQEMEKLQAKEKHKERLSRRHENLKPGYCEICRIKFDDFNKHVNSNKHKKQSTDPKIWSSIDLLLRYTARPLAKATEKPPPSPATKLSPPPSPKKLRRYENDEKEEVIVHNDIQNTVSNTQEPLLAESTFIQNSQATTAGGAPQTTQSQESSKRSQEVVKKADCFEIAQEGVQPPNEDDMQEFDQIEDYYRDGFYSNYDQQQLQQQEDIELLNSQWDELQSVINMEHDLPKAISHDSITREDVLNFIEGDNTATREYNNTVQAYEDGDGYVEEDQLEEMAPNMPAKETSPETAEVQRSFDVFEGQPIYETQNKSPLNHNGGSIDWINTLTEVFKQHLSEPNDQPHSHHQSSSHSLIEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7J4</accession>
    <name>I4Y7J4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960075.1">
        <property type="nucleotide sequence ID" value="XM_006960013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7J4"/>
    <dbReference type="GeneID" id="18471738"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33741"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="InParanoid" id="I4Y7J4"/>
    <dbReference type="OMA" id="FHNMGSQ"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="533" mass="58537" checksum="3D74B5A0D4F62876" modified="2012-09-05" version="1">MPILKKTGIRSTFFPDGSNQQQVEGAEHEQREDATSSEGKNEDGNIILIAFEENDPENPLNWGKGRKWLTTSLLNAMTMIIGLSTSAYSPTTDAIAEDLGVSSEAALVGMFTFNAACSVGPLFLAPFCEMVGRRYVYIGGFFCFTAVFPMLAAGQNIGTMIVGRLLSGLFGCIGTILVGGTLADIWVDEERSVPMSQFTFVAIFSTIAAPAYCGYIVERVGYRWVEWVHMIASGTLLLIELFLFKETRGATVLAQRAKKLRKETGDNRFRAPIELESESIKMLLHKSCTRAFILLAREPVILFFGIWIALSWMLVFMFMTVIPLTFSGNHHWSTGKAGLPYIALMIGCVLGYISGFWSDHMYNKSAEKNGGKPVPEARLYGAMVFAPFFPIGLYIFSFTQYSHVHWIAPTIALVPMIFGIYHVFLAVYNYTSDSYGEYSSSGIAGQGLLRNMAAAASPLFATQMFKGMGYQFAGLFLALLATAIAPLPYILFKYGKTIRAKSKFASATTGLTDETNDAVANAELGNTVQESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7N3</accession>
    <name>I4Y7N3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L13A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959906.1">
        <property type="nucleotide sequence ID" value="XM_006959844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7N3"/>
    <dbReference type="FunCoup" id="I4Y7N3">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7N3"/>
    <dbReference type="GeneID" id="18471721"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33621"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7N3"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="199" mass="22386" checksum="E74607D448F72FF9" modified="2012-09-05" version="1">MSTYSAAPVIVDGKSHLLGRLASVVAKNLLNGNRVVVVRCEELNLSGSFFRRKLEYMKFMRLRHLVKPSKGGPFHHRAPSRIFLKAVRGMIPHKIARGAAAMQRLKVFEGVPPLYQNKKKMVVPQALRVLRLKPGRKFCTLKRLSSEFGWAHAEVVDKLEAKRKAKGAAYHERKVAATKLRANAFKDAPQNAKLAEFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T1</accession>
    <name>I4Y7T1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959952.1">
        <property type="nucleotide sequence ID" value="XM_006959890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T1"/>
    <dbReference type="FunCoup" id="I4Y7T1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7T1"/>
    <dbReference type="GeneID" id="18473017"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58417"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y7T1"/>
    <dbReference type="OMA" id="PTATGDH"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="125"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="284" mass="29282" checksum="E586110BC9E83063" modified="2012-09-05" version="1">MSFLKSFGDNAKKFSNQGLNLAKTGANSATTFAGDIAKRPELDFSLPRECDKSADILKSFLANPDDPSSALNSIPKAVLQRAKGLAVFRIVKAGFIVTGRAGSGVVIARLDDGTWSAPSCIATGGIGWGLAVGADITDFVVVLNSKEAVESFAYAGNLTIGGNISASAGPIGTGGGVQAALSDPSPLFSYSMSRGLFAGVSLEGTAIMERKDTNSQFYGTSIPAKDILLGRIPPPQIAEKLYTTIEAAEQVDESGLPSEAYVPPPPEAAAGGKSKGQMLFDASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V0</accession>
    <name>I4Y7V0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959971.1">
        <property type="nucleotide sequence ID" value="XM_006959909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V0"/>
    <dbReference type="FunCoup" id="I4Y7V0">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V0"/>
    <dbReference type="GeneID" id="18474391"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61204"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="I4Y7V0"/>
    <dbReference type="OMA" id="VNGWIQM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="40"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="375"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="694"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1262" mass="137942" checksum="F57ECA6BA9ABC15D" modified="2012-09-05" version="1">MMDSANSVNIAIEEDKKDKSSVSFFALWKYSNGLEKFINLVALVAAIGAGTGLPLMTIVLRDFTDSFVEFGSAIQSSQANIDEITQKFKTDTNSTAIYFIYIAVGVAVLTYIFLSAFVITGETVAGTVRKEYFKSILHQDISYFDNIGAGEIVDRIQAQTLLLQDGISQKVPLVIMSCSTFIAAFVIGFILEWRLTLVTAAIFPVIMIVGTASEMFSSKYQSRALEGQSKASSIAEEALSSIRNAHSLNYQKQLNQLFGKHASEVKNNNLLNAIVWGISMSGFYFTSNSAYALAFWFGITLTIWGYTQAGTVIAVFFCVVIGSFALTMAPTHMQAFALAQNAAANIFPTIEDDNAISARADEGLRPSTDTLLGHIAFDAVDFIYPSRPSVTVLKGFSVDILPGKSIALVGSSGSGKSTVVSILERFYKPKSGSVTLDGKSIDDYSLKWLRSQIGYVGQEPVLFSCSIKENVEYGLIGTEFENKSADVKFQLVQEACKKANAHDFVCELPEGYETDVGNRGFLLSGGQKQRIAIARAIVSNPKILILDEATSALDTLSENVVQKALDNASTGRTTISIAHRLSTIKNADSILVMKQGTIVEQGTHDDLIQIQDGIYAGLVAMQNLDQDSSKPQMILPSQVLSKEDEKGSVSSDMKELVRKDGNEIILDTTDKKYGLFRIIMRLGKLNQNDWLIYIIAFIACAGSGMCYPVLSIIFGSAIEVFQADNDSDLRNDGNRQALFFTAIAIVSFFTFGISNWGCMHTAANLSYKLRMASFENLLLKDVSYFDKSENSIGKILNYVSDGPQKINNFAGMTLATILSNLVTLVGGMIIALCYGWKLALVCIACIPLLLCAGFAQLYFVVQREERNKKSYSKSSSLAAEAATAIRTVASLTCEDFLSKKYDDTVDGVIKSSSRNALISHIFYAISQGLQFLVMALAFWYGSRLLANLEYTTRNFFIVLISVIFASIEVGMVISYCSDLTKSKSAAEAALNIIDYEPLIDTNATAKSEANNITGHIRFENVFFKYPTRPEVQVLSGVDLDVKPGQIAALVGASGCGKSSTIQLLERFYDVQFGKITIDGTDIREFNVKDYRKNIALVSQEPTLYSGSIHYNVAIGSQSENVNDVLESDVIEACKAANIHDFIERLPDGYKTDVGGRGLSLSGGQKQRIAIARAFIRNPKILLLDEATSALDSESEKVVQNALEIASRGRTTVTVAHRLASIKNADVIYVYHNGGIAEKGTHSELISKRGFYYAMFKEQQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W8</accession>
    <name>I4Y7W8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_21316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959989.1">
        <property type="nucleotide sequence ID" value="XM_006959927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W8"/>
    <dbReference type="FunCoup" id="I4Y7W8">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7W8"/>
    <dbReference type="GeneID" id="18470883"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21316"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y7W8"/>
    <dbReference type="OMA" id="FHWTKAS"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="38574" checksum="754730C46C20C091" modified="2012-09-05" version="1">MITPYKGECIHFFDSIFSCHHSLRIGAIFIVLATSAFGTLLPIITGRIKGLGLPKIFYDTVKYFGSGVIVATAFIHLLAEAFEELSNEECLSGAWNDYDWSPALAEASVFFIFFAELWASRLGNKYLQRRGLEYDNHGHEGIGGIAGSHGAETHNPETPHLHDAPAATIGDRKSAETNDVESVHTAHSYSYNTMSMVTGVAILEFGVLFHSAILGLTLATTASDEFRVLLIVVVFHQMFEGLGLGARLAELPLKQWWIPYTGAACYFLITPVFIAIGLGVRETYNDESTAALIVSGVLNSLSGGILLYTGLVELLAHDFIFSSHMKNASDIYVLYASFCVLLGAGLMSLLGYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Y3</accession>
    <name>I4Y7Y3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959796.1">
        <property type="nucleotide sequence ID" value="XM_006959734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Y3"/>
    <dbReference type="FunCoup" id="I4Y7Y3">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Y3"/>
    <dbReference type="GeneID" id="18474336"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61107"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y7Y3"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="306"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="442" mass="49858" checksum="A4C93CB2420CAB93" modified="2012-09-05" version="1">MSASSAFYNITPKLWNKLLHFSSFPQTGISLQQMVMFGSNPSQGTLLRAGNFLSEELPIRLAHRCVELNTLPNNLSQMPSIQRVLGWYAHSFDELINFPPPQLSAEVRNQLFAQSNKIGKLPEAKPNLAQLEDEHTPGPVNPIQNNGSKNRRIPIEYRYHAETPNYEWPIEVGEYNENFTRLLEGIKKRHDTVVPTIAQGVLEYKKHRQHIGRGVDTDIQSFLDRFYMSRIGIRFLIGQHIALNSINQPKDYVGIICKSTNVRDVCDEAIDNARFIAEDHYALFKPPQVQLICPEDLTISYVPGHLNHIVFEIIKNSLRAVIERFGVDAEDQMPPIKVIVAAGNEDITIKISDEGGGIPRSAIPLIWTYMYTTMEGKGLDPEFEQSGSDYKAPMAGLGYGLPLSRLYARYFGGDLRLISMEGYGTDVYIHLNRLSSSAEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y804</accession>
    <name>I4Y804_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959817.1">
        <property type="nucleotide sequence ID" value="XM_006959755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y804"/>
    <dbReference type="GeneID" id="18474342"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61119"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y804"/>
    <dbReference type="OMA" id="YCLQKNW"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31072" checksum="255EECADD3A89878" modified="2012-09-05" version="1">MPSVNNISSTYRLASGHEIPAFQLGVYKSSSDVAKNTVTSALKAGYIGVDTAQYYANEVQVGEAIREAGKQAGDVFVTTKVMESAGDVDANYKRCLESIEKIGLGYVDLFLIHSPRQANGATDRKSLWQALERLAKEGRAKSIGVSNYGVKHIEELKKYASVPVSVNQIELHPFHQQRAIVEYCQKNDIILEAYCPIIRGQKKDDPTIVKISEETNKNWAQVLIRWSIQRGFVTLPKSDNPERQKSNADIFNFELSTDQMARLDGLEAGHHVAPCPVDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8F5</accession>
    <name>I4Y8F5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_21049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959735.1">
        <property type="nucleotide sequence ID" value="XM_006959673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8F5"/>
    <dbReference type="FunCoup" id="I4Y8F5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8F5"/>
    <dbReference type="GeneID" id="18470871"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21049"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333232_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8F5"/>
    <dbReference type="OMA" id="PQMSESF"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="690"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="770" mass="86802" checksum="4830F604C2B3E68D" modified="2012-09-05" version="1">MPVPQYPTLDNEPKRPVYKKHNKSFDALRNGQWSSFNASESKHKHFQFAEGDVPKSKVLRLYFFLINTSIITRWAIFVLPIAGVLAIPLIVSVTTAPDAELLRVRLLWWSIWLETLWVGWWVSWAASKIIPWVAKHTVAVIVPNGKQMIDYFVRCERYLAAVGWTVACWAVFNFVVLVKFSRDHSDSSYSTLSVIAQVHAGIIICASILAGEKILIQLIAYNFHRTSYDDRIREQKFQVKVLAALYARSRDLGRSDTLDGFGRRGKEKGVKAGRVFRKAAREAKEAAANATTALGNVASEIAGSSVLQPNSPMSMVTNALGSGKKTRHLARRLYYSFCPPYRTSLVQSDIESFFPDLNTAEEAFAVLDKDVNGDVSLEELEMACFEVHRERLALTSSMRDLDSAVAALDKILMSIYVVAACLIIVAMLDVKFSTLVTSAGSLVLGLSWLIGTTAQEILASIIFLFIKHPYDVGDRVKIDDFDMTVKEINLLYSIFKRIDGTVTQAPHVILNQKYVHNVRRSGSTSEDFNFNVAFDTTFDQIEDLRSRMLHFLKSEKRDFHPICDINIVDLPDQEKMTLSTSINYKSNWQNISLYTQRRVKWMVAMKIALSESKIFGPAGDPDAPPIPARYMKVPYETPGKVEEMPAPLPDDARTADLRRAASMALNGGRRALIHRMDAEEEALFHSGLETVPRENTDDSFNMPMPYGNAPQGTAPSMPTPEHYDVDSDRATPAQLEAGRVRIQSPEPIRSRPQQQEHQQRGRQDYEMRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J4</accession>
    <name>I4Y8J4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959774.1">
        <property type="nucleotide sequence ID" value="XM_006959712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J4"/>
    <dbReference type="FunCoup" id="I4Y8J4">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8J4"/>
    <dbReference type="GeneID" id="18471698"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33512"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y8J4"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="11">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="10">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="394" mass="43595" checksum="642FCDD9FD9037FC" modified="2012-09-05" version="1">MTKGRMREFYQCDFDIAGSFDPMIPDAEVLAILSETLSKLDVGPFTIKINHRKILDGIFELSGVPQDKIRTISSAVDKLDKLPWEDVKKEMTDEKGLDSEVADRIGEYVKLSGGRDLLEKLQQDSKMQSNEKAKKGIEEMEILLNYLEIFGVLPQLSFDLSLARGLDYYTGVIYEAVVEGSKAPVLAPAATAAPAGSKLQPPVVKHTGTKKGSKDAELKHESDIDESQIGVGSIAAGGRYDELAGMFAGGAAKDQIPCVGISIGVERVFSILMQRVEKEQQASRAKQTEVYVMAIGDGLLAERMQVAKQLWDNNIKAEFFYKAKPKLPKQFEVVDKERIPFGLLLAPREWNEGQVRIKEQKGKEDGSGDGDLINIKDLIPELSGRISEWRKNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K3</accession>
    <name>I4Y8K3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959783.1">
        <property type="nucleotide sequence ID" value="XM_006959721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K3"/>
    <dbReference type="GeneID" id="18475042"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65646"/>
    <dbReference type="HOGENOM" id="CLU_1604026_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8K3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="166" mass="18599" checksum="F52BC24E86381AD4" modified="2012-09-05" version="1">MKTKRHDAIRNYLAKFLSASGLKVDMEMPLGSSDNKRMDLVLKESNGSGALTMHDITVHSSIALVPYIQQVTKDWQKKSGSELIRVGLNHQAHKKVLKYRDHVPVTFVPIVFAMAQDYSQLGPPTEAYFVCARKEESDKLPADLGSILRCLILKILTLSNNLFDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K5</accession>
    <name>I4Y8K5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959554.1">
        <property type="nucleotide sequence ID" value="XM_006959492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K5"/>
    <dbReference type="GeneID" id="18475656"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69873"/>
    <dbReference type="HOGENOM" id="CLU_850479_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8K5"/>
    <dbReference type="OMA" id="QMRRINN"/>
    <dbReference type="OrthoDB" id="3354778at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="327" mass="36616" checksum="7403A8E0E8079293" modified="2012-09-05" version="1">MVRSDTNAPGRLRQLARRSTLNFDDTLSGLPSAPLGPGWRSAAADLLATGEAAVQRRRSIRHLRRSATVDNPPSEQHSEQDLEKLPLHVHDNNEGVFVDGEGPMFPDIRIRFHVDPPNSIIMTLNNSLYDDQKSPDSFLLTRLELVVPYKSDGLVFASLDKITVEDLSVYDSQCLPVLERYSSQLKQPLGPGIDRKIYPDPIPSTSSFAPIHYHSSQSQTLTRRLEDPVTSPRPHKKAKKNTPESPPPLLPFPTTVTPCAYFNSYTESIESVPFAPPQRLTIDLQPGRATRYLAIRFLNSHGSRFDASRVKAFGYRASKVYNSSEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Q3</accession>
    <name>I4Y8Q3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tup12</name>
        <name evidence="12" type="ORF">WALSEDRAFT_61011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959602.1">
        <property type="nucleotide sequence ID" value="XM_006959540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Q3"/>
    <dbReference type="FunCoup" id="I4Y8Q3">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Q3"/>
    <dbReference type="GeneID" id="18474284"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61011"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="InParanoid" id="I4Y8Q3"/>
    <dbReference type="OMA" id="GTTHMML"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="514"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="556"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="594" mass="64965" checksum="820EF0DB620ED343" modified="2012-09-05" version="1">MSSNSIYNHRHLQPANAAPAPAQPQSVSTSRLGELLDIVKQEFDSISSNGVMIKEQRDEYEHKLAAQINEIHTLRQSFHDLKNLHTELVTRYEEEITRLRRELESRQGQSPITVQPNSAQATRAGTPTVVAPTNKPTTLPPPSLNQNAQPFSAINPPKSYPHSPLPSGTAPYAAQPTVPPQLQSATRPQSPYPIPPVQQSQQAQPQPPSSEQQQSSALQPITPNQSIDFGDPEAFPRDFKKEGSDWIAMYNPSIKRNIDVSLVHNLVHESVVCCVRFSADGRFLATGCNKTAQIYDTKTGAKTCVLADDNVPIKGDLYIRSVCFSPDAKYLATGAEDKQIRVWDIAKRKIKSLFTGHKQEIYSLDFSSDGKFIASGSGDKTARLWDVETNTCLHTFNIEDIIMCDTGPIDSGVTSVAISPDGRMVAAGSLDTKVRVWDVKTGQQLERLTGHKDSVYSVAFAPDGQSLVSGSLDRTLKIWDLSGTIKAINGGNPPQVQNEINGEKTGYAVCINTLVGHKDYVLSVAVSPDGQWIVSGSKDRGVQFWDPNTAQTQLMLQGHKNSVISIDLSPRGLFLATGSGDYHARIWSCTAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R5</accession>
    <name>I4Y8R5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">WALSEDRAFT_40048</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959614.1">
        <property type="nucleotide sequence ID" value="XM_006959552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R5"/>
    <dbReference type="FunCoup" id="I4Y8R5">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8R5"/>
    <dbReference type="GeneID" id="18472151"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40048"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8R5"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="198"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="498"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="966"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EIM20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119646" checksum="561AEA5CB8F12F0C" modified="2012-09-05" version="1">MSNPINKKRKITDDTKSIKQASQGDKKQSTFADILESLQDEAEKNSTESSQVWGRPSVPKFESMVEPIIFQQIDLEEASIPGAEPFIRMHGVTQDGYSVMANVTGFLPYLYIAAPRGFTKEECEGFSGYLNATFGNNGKRIVADMEMHTKRSLWGYKGDEKSPFIKITFVDQRSMTRVRGCFERGEIHFREFFDDAIQTYESNISYDLRFMIDKKVVGMSWIECPGGAYNLKASTSKVSKAQLEFDIHHKDIIAHPAEGEWQKMAPLRILSFDIECAGRQGIFPEAQIDPVIQIANMVTRQGESKPFIRNVFTLKSCAHIAGSQVLSFEDESKMLNAWRDFVEEADPDVVIGYNTSNFDIPYLMDRAKALKATKFCYLGRMKNVKSEVGTSHFSSKAYGTRDSKTTNMEGRLQLDLLQLIQREHKLRSYSLNSVCAEFLGEQKEDVHHSIITELQNGTPESRRRLAVYCLKDAYLPQRLLDRLMSLVNQTEMARVTGVPFNYLLAKGQSIKVMSQICRQAQVHGYLVPALRVEGSDEQYEGATVIEPRRGYYDVPITTLDFSSLYPSIMMAHNLCYTTLLDPQTVERLKLKEGEDYIKTPNNDMFVTPVKRKGLLPVVLQDLISARKRARADIKSEKDPFRRAVLDGRQLALKVSANSVYGFTGATIGKLPCLPISSSTTAYGRRMIERTKEEVESHYKVSNNYSHDAEVVYGDTDSVMIKFGCRDLETAMKLGAEAAGVISSKFPNPIKLEFEKVYYPYLLINKKRYAGLYWTGLEKYDKMDTKGIETVRRDNCRLVGTVITTCLHKMLIDRDVKAAEDYTKHVISELLQNKIDMSQLVITKALTKTEYDAKQAHVCLAERMRKRDAGSAPALGDRVAYVIVKGSKGAAAYERSEDPLFVLENNVPIDTKYYLENQLSKPLLRIFEPILGEKSQSLLTGDHTRTITVATPSIGGLMKFAVKTVTCLGCKAPIRGSDAAVCKNCKGKAGELYQKQVASVSALQVQFARLWTQCQRCQGSLHQDVICTNKDCNIFYMRQRSKFEVASAVNTLERFNDDNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R7</accession>
    <name>I4Y8R7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_47743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959616.1">
        <property type="nucleotide sequence ID" value="XM_006959554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R7"/>
    <dbReference type="FunCoup" id="I4Y8R7">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8R7"/>
    <dbReference type="GeneID" id="18472426"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47743"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001040_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8R7"/>
    <dbReference type="OMA" id="LPEMKGW"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="237"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123181" checksum="894012D201AA0860" modified="2012-09-05" version="1">MAEDDGAIITFNLLKYFQANDTAAIKDVVDSQNAAGVLLLAVKAANPPTISYLLSLDSIDPNEVDQDGNTALHIAASINRADVVELLLQNDAINDSVRNNNARTAFEICKSESCASIIHDSQIKLNEKYRDLVSEYIRPSSPDSRAGEELIQLLKLPRSPVIDLSYIDTQSGSTLLHSAAAKKDFQLIKVAFENAAASSTIIDSRQKTLLSSCKDDQIKSFIKLQERQKPNAQNVQTRNKKGILKKYVNMASGWQNRHFVLQDGLLNYYLSPDDEAKQLSRGSINLEYGRLKEDKSGDNRKFEIHSPNNKFLVRADHPTDAASWKQAINLTIQDIKSGDRNSIDVQRSPSISGGRSLYAHSHSHSRHGSKSSLTDFQSVRGASPTYSIDETIESYDVNSIPHADKFELEGQKLSAHIEATESLMNTFLKDDAEGDKESHNERKQALKGSIETLHGLVNDWQAMVNDREVYYKKVLQHERETARLWEENIATIAVETAKVEGELENIHKSQEERRKALKQKKSDLHDAALGTSSLSPPSKAAVIDSGETAPTRSDGNIYAGQQDDQSGVSAPPQAAQHAPIKDAQRPSPMARVSSEEDDDDDDFFDAVEEGTLPINQDIVQAEKDDPPVEDLVPYEPYRELRSEMPISDDKRPPISLWSVLKNSIGKDLTKISFPVMFNEPTSMLQRMAEDMEFTECLDAAAKNPDPFKRVAYVAAFAASNYSSTMGRIAKPFNPMLGETFEYCRFDKQYRYFSEQVSHHPPMSACWGENPRWIYKGEVDAKNKFMGTSFEIRPTGIAHIELKLPATWAKEGVTYPREKCKVTGEELIIEHYSWKKVTTAVTGFITGSPVIDHFGDMVVVNHRTGESCTLTFKARPWRGKGQEIKGFVENAQKQHKWVIAGRWITQLVAKKIEHGTEDIGADEQIDNSAEYLLLWKNSEKPKLPFNLSPFAITLNDLPGDQLATLTPQERADLKKWLPNTDCRLRPDQRAFEIGLYDLANDLKIQNEEKQRATRKERETGKLPPHKPRWFNAVKDPDTGERVWMPTTTKAENGQNQIDYWTEREVVGKSRLDGDESRKFKNVDDVSLDGKLMTVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8S0</accession>
    <name>I4Y8S0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_29699</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959619.1">
        <property type="nucleotide sequence ID" value="XM_006959557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8S0"/>
    <dbReference type="STRING" id="671144.I4Y8S0"/>
    <dbReference type="GeneID" id="18471111"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29699"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8S0"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM20362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="459" mass="49974" checksum="074DB9566CA53698" modified="2012-09-05" version="1">MVVRDPSLPLHKQLPDKGLSKDAVENHLVALGGLEHSKWEEGRVSGAVYYGDKGDVNDIIVDAFRRFTVSNPLHPDVFPGIRTMEAQVVSMVLQMYNAGPDGAGTTTSGGTESILLACLAYRNWAKEARGISNPEMIVPVTAHAAFNKASYYFGITLRHVPVDPETRKVSIKHVRRALNRSTCMVVGSAPNFPDGNVDDIVELAKLAKKYGVGLHVDCCLGSFIMPFLKDARLVTTPFDFSVDGVTSISCDTHKYGFAPKGSSVIMYRNKTWRSYQYYSQPDWTGGVYASPTLAGSRPGALIAGTWAVMSHMGQEGYVQSCRDIVTARISIQEYIEQELSSDLAIMGNPISSVVAFKSVNPSLNIYTVGDLMHEKGYSFNAIANPPALHIACTRPTLTAVDDIKATLKWAVEEAKSRKIDKKDEGSMVALYGVGSSTAIGHDLVDYLAKGFLDTMYVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X3</accession>
    <name>I4Y8X3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959441.1">
        <property type="nucleotide sequence ID" value="XM_006959379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X3"/>
    <dbReference type="FunCoup" id="I4Y8X3">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8X3"/>
    <dbReference type="GeneID" id="18474237"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60904"/>
    <dbReference type="eggNOG" id="KOG1709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033831_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8X3"/>
    <dbReference type="OMA" id="YWVVDNY"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="110"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="38050" checksum="61058FA4A5DCB631" modified="2012-09-05" version="1">MALLHCCATDDIENVKQLIDKGAPIYYQDASSGYTCLHFAADIQSTKLVKYLISQGATWNALDHTGYTPAEIALSYGNEKIYEEIVGEGVRAEFLLNLLGQKAENDEADPASSLNAFLSSKLTYEYDDNGQERVVDSAGDPVMMAWETPIMKSSVAALCDNHEDASDEGLAILNVGFGLGIIDTEFQKQQPSNHTIIEAHPDVLKHMKETGWYDKPGVRICEGKWQDFIYEIGQFDVIYFDTFSEHYRDLHAFFEHIPELVNSPNSRFSFFHGLGATNPVFYDVYTRISDLHLDQIGMSAEWQDVPVKELSAVWKGVRRSYWNLPCYKLPIAKMNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y981</accession>
    <name>I4Y981_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959549.1">
        <property type="nucleotide sequence ID" value="XM_006959487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y981"/>
    <dbReference type="FunCoup" id="I4Y981">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="GeneID" id="18475017"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65411"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y981"/>
    <dbReference type="OMA" id="QACWTII"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="848" mass="96811" checksum="DBA22EAB7399642E" modified="2012-09-05" version="1">MVVESDSEKKRKITRACDICRRKKIKCDGPSKAEQGLKCSNCDNNNFTCTYVEAAKRKGPPKGYIESLENRNRRFEMLFRKMLPDYDYNSQVGSPIDRDNFETGCEADTSRWNKQKKELPTIENAFHPTQEIDDQSDDELEERMQQISVSAQCEDNTRYLGKSSSVYLMATLDQYKPPDEPPITREVMEQDRRPEFWMDREWIMEEKKDFPSVSYTAEELPPPDLLEHLVKIFFEKFNVYFPVLHRASFEADLHKRKDDIRFGGLLLLLCATASRYSDDPRVVPKDDKDEFGNVKNWRFAGAEFFAKFKMHCHSFILTAATLEDLQSIILMIIYLQGGPFSPACWALNSMGLVLAQDIGFHRKRVWGDPIQNELRKRAFWSFYMMDKHLSAMLGRPCTLNDENFDVELPSVLPDEVETEMQMTITQFNKLIELVAILGEVLRTIYVVNKRKRPNNANIPEPKRTLMDVAALDSKLHKWLESIPPELAWDPNCKDNLKFTFMCMLQTTYYLVQIYIHRPFISTPKRPSPLGYPSLSICTNAARSCIHVLSHLQERNKTTKVMDSWTGIGSFTSSVILIVSACEGRRNSTDPSAPIPEMKEINMGMQVVKELEARHLHAGRAHDILRKLVNGIGKIPTEESPNATSPATSNFSASSSLSMDSNLFLRGSTENLFNPPQQRRKIAKKPSHTRKNTQDLEDLPMSTNDLATHIFYPDMVNDTATTENTTTSLTEMANLVDQGVFPSGNFDFTAPTSSEVMPQSTFVQPPTSQMPKGYNDVNMAGINTLTDYDMLGNSNPLTNMFTSSPEDDTKPSVTQDAVPQQDLWSLLPDSTYNTQSEDWTNFFRFTQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I0</accession>
    <name>I4Y9I0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_52070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959408.1">
        <property type="nucleotide sequence ID" value="XM_006959346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I0"/>
    <dbReference type="FunCoup" id="I4Y9I0">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9I0"/>
    <dbReference type="GeneID" id="18472574"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52070"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9I0"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="43"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="203" mass="22455" checksum="909A99152EBBD2AF" modified="2012-09-05" version="1">MAPVKTLPSEVKGGLAGVKLFGKWDAQDVEVKDISLTDYIQVRHPVYLPHTAGRYAVKQFRKAQMPIVERLVNSMMMNGRNNGKKQLAVRIVQHACEIIHLLTDQNPLQVIVDAVVNTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAVALLTVGVRESAFRNVKSVSECLADELINASKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9L1</accession>
    <name>I4Y9L1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959188.1">
        <property type="nucleotide sequence ID" value="XM_006959126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9L1"/>
    <dbReference type="GeneID" id="18472967"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57952"/>
    <dbReference type="HOGENOM" id="CLU_1918699_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9L1"/>
    <dbReference type="OMA" id="HPNHTEH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="132" mass="14851" checksum="DAFAC179035D9E3A" modified="2012-09-05" version="1">MTSRYLQNMQKQYYNLNQQLNSPCHNFEKVQAPVTSVPNSKLKVKRWVHNKDLKLDLSDDEDVKEVINIDESDPNSTKLNLDDSTVDNTHANTPDFDPGTNSVDPADPSAAAKDVIHPKETQHLHEPSTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9S5</accession>
    <name>I4Y9S5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959250.1">
        <property type="nucleotide sequence ID" value="XM_006959188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9S5"/>
    <dbReference type="STRING" id="671144.I4Y9S5"/>
    <dbReference type="GeneID" id="18475615"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69634"/>
    <dbReference type="eggNOG" id="KOG4370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532324_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9S5"/>
    <dbReference type="OMA" id="ANRANDQ"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="269"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="512" mass="57774" checksum="1719E7865E163E9A" modified="2012-09-05" version="1">MQITKKDEYLEPSSPTISPALIYFIQNSQQSSTDEQSQKVARSTPTISSPKFESTTEELNKRPLSVMFNNVGGTSGQTYQPDDDNDRKSNRSSSTTITNGKRNSQRRRTKPSLQIFNSPSNPPSRPPSMSISTSNIPQAATSSYSPSLKSVNHYRNISTDYLSNKIQGWMPNFSNSLSTPQISSESSSFDNGYKDISNTTTKDKDKDKDSKRGMLGKAFSSLHFNDISKVNHQTSISNFRTRVGKSNQKLVFGVNLQQSSYYTKIDKSTSLWKIPIEAKDHLPCLIIRCFEYLIQWAIVEEGIFRISGKSSQILQLKNEFDSGSDINLRDIHPSVLDPHAVASIFKAYLRELPHNILSNETIPQFNDFMQITYKVNAVTSDDAPAAAFKCNYNQTEGKDFNQLDLKLLKDILNDLPCSNYWLLRLTMKILKLTADNSDINKMTLSNLILVICPSVNLSAQFVKVLVTHFDVLFGSDDVEDSEEEELGYLRSNTPSQQTKSTHNKFRLLKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Z6</accession>
    <name>I4Y9Z6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959053.1">
        <property type="nucleotide sequence ID" value="XM_006958991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Z6"/>
    <dbReference type="GeneID" id="18474108"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60699"/>
    <dbReference type="HOGENOM" id="CLU_1556470_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Z6"/>
    <dbReference type="OMA" id="WFSHARY"/>
    <dbReference type="OrthoDB" id="10420793at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19173" checksum="3E329A69AA732A87" modified="2012-09-05" version="1">MSFLIGFARFIKVIIIAFSITILVLGAVYTRDVSDWFRGAHYASAIAALLAASALNFLTTLIPLSYGGLSVGLNMLLYLFNFLFTFATSIAVAALREGRGGMAYCRLIEPNRMFSHCFDQYLGLIVLGFLLSIFDLFLVIIYPIAVSLHNKRVNQSNGFRTRMDSLLPKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Z9</accession>
    <name>I4Y9Z9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959056.1">
        <property type="nucleotide sequence ID" value="XM_006958994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Z9"/>
    <dbReference type="FunCoup" id="I4Y9Z9">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Z9"/>
    <dbReference type="GeneID" id="18474109"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60702"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y9Z9"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="489" mass="55878" checksum="086FA398AF76F771" modified="2012-09-05" version="1">MIRTAVILRTAGRNFRVNRIHLRRTSIRKQSTLSSEETEDGYAGRSQPKLNVSNTPIEKYKDLINDKVLKPDNHQFRIISKLNDLHTELTTYQPSAIIELDERISTKTEDLPWWKKVVSGKSQALIESEREQAVKDKRSRIPKGLYLYGDVGTGKSMLMDLFHSTVPEQFTPKAQRWHFHAFMQAVHKRIHKARIAGSIDPLGQVINDIAEECTVLSFDEFQVVDIVDAMILRRLFEGLIDKGVVSVMTSNRHPDELYKNGIQRDSFIPCIDLLKTAFQVVDLNSGTDYRKLPRALNKVYFSPIDRENTSEFEKIYTALTSNKTIQYSKELEVWGRKLHIPESADNVAKLTFNDLCGRPLSAADYLEIVHNFDTIFISEIPKLSLNVKDQARRFITFIDAAYESKTRLFLLSEVPIESIFSDESNNTGEITDVMRSAMDDLGLNVEIVGASSMFTGQEEIFAFARAVSRLTEMSSRQYAELSTKTYDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAB6</accession>
    <name>I4YAB6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_69571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959167.1">
        <property type="nucleotide sequence ID" value="XM_006959105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAB6"/>
    <dbReference type="GeneID" id="18475600"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69571"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423478_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAB6"/>
    <dbReference type="OMA" id="WFSRASM"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="623" mass="70518" checksum="960DF63D2F2753C7" modified="2012-09-05" version="1">MPKNENTLKRGQACLHCRKRKARCDGAKPACISCVKGNHQCVYVDTSALSTSRRRDKISDLEERIRDLENKLATQHLSTSTSFEDTTNAPYFEFSSPEPLLATSNWPYPPIDITLHLIQVFFTCCPVESSHLHKPTLLQTVLLPMTHPEAPHPALMYAIFASASRHSLRTTNSKPRAANGWTERACNSTGNTFLDMSLSTAANYLEVETKSHTSLRDKLKLISAIIILTHLMHRENKWTDLHQFNTLGTRAMVSFKLHLDEKLENPKSRLIASSQSDLEREQRKRCLFLGFLFDTIYASTTSMFPSNLNSRNIYIRLPVSTQMFNQASHDSIIPELEPFTYSSDFLSNHSSDDNFHCLIKAAILLDKVNEFLHGSIGELVESSLSSSNQLPSFNKLDKVISEHKAQLPDYWDRNKNLDILMYFAHMIVHDGTMKLHNGYFREPTSRKRLMGTVRAIISPLYILLNLSFDFTRLPTFVISIYIDAFDILIIAHKNSDESAQAKIVKELGTIMEVIERISEKIPHGVEALKNLNQSLKKNGIPLGTHPEQVDESSLTVFNTIMQQVNNYDVTPQFGEGVLDITATSPLEIPPGMSFPTNDEFKWMNTDDNFNDAFLDTAFIDGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF7</accession>
    <name>I4YAF7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958942.1">
        <property type="nucleotide sequence ID" value="XM_006958880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF7"/>
    <dbReference type="GeneID" id="18474074"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60652"/>
    <dbReference type="HOGENOM" id="CLU_650857_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAF7"/>
    <dbReference type="OMA" id="PLIPNTW"/>
    <dbReference type="OrthoDB" id="10627798at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="422" mass="47450" checksum="AD10145A138B3606" modified="2012-09-05" version="1">MQSVSNLDDLVRLIKEGTCYSTLFKHSLIVATLVGVIVLLSLIIVSKYTTLKQTYLGRNRSDLLSSLLRSALLLSAGFGSLAFSIQDAPLENQIFLLIVTNVYAAITFYLDSAFALLKHIQVHLGVVKQLKLTFLTSTSLIAIASTYFDKRLWSPLLLILGYNVVESGHANQEDVDYWLENCAIAVTIPIMPDAWNDETRYALIGSIAMFSAIRRWYVNGFHRNEESLQHLSYPVICWMVSKMNGSLVNYSLMLFVAWIRLQQPTDKLGWSEVSTALQAFAILQYVFAMGCNSSSLVNAYDVLKSHGLKLQNVNIALRTFDDGSSIKYAFLSVVMIICIANMFKRIDIPLLAFFLLQISFLNVVVLLIYALSFFMDVGVKLDAAVSLNIVMPIIFACSSILFSHLKNKREETIKWEVEEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAQ1</accession>
    <name>I4YAQ1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959029.1">
        <property type="nucleotide sequence ID" value="XM_006958967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAQ1"/>
    <dbReference type="GeneID" id="18474101"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60690"/>
    <dbReference type="eggNOG" id="ENOG502SB48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076420_3_0_1"/>
    <dbReference type="InParanoid" id="I4YAQ1"/>
    <dbReference type="OMA" id="CGAAYHR"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23496" checksum="5E0FE1062C03D4FF" modified="2012-09-05" version="1">MGRAAIPAVFLAFAALVLYIFITVSTPVWDKVNFFSIQVPSVNVANINITPGTIKYGFLGWCYNDQCSDKSLGYRLEDPINQLPGVNITIDNKAVENITYALVLNPVCGLLSLLVSLFGLLAIRGGRITAIFLTIFEGFTALVGIVTLALNVALFKVFQNIMNDRLDIPGAQIDSKLDNAEWLSVAAAGCLIVGSVLSLLGICFGRSSTRRRDISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS5</accession>
    <name>I4YAS5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958752.1">
        <property type="nucleotide sequence ID" value="XM_006958690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS5"/>
    <dbReference type="FunCoup" id="I4YAS5">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS5"/>
    <dbReference type="GeneID" id="18474030"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60561"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1082590_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAS5"/>
    <dbReference type="OMA" id="FYFQSSH"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="27809" checksum="7EC40ECAD3894D01" modified="2012-09-05" version="1">MRRTSIRFLQLPTKSNASPFEIFSLPSTATSKEIKARYYELVKIYHPDRCTIGDQQKHTKDFQAIVRAYELLSDTKKRQQYVDTGVGWTSDGAQSKWDADMEFIRRNYGHRRSTQFASSYTPPYSRRSGGWDGEFYWSTYHHPSTGRHKPVYSSNGAFISGLIFFSAIVTIIEYQTFFPTTMIKNSFTKSKEVDPLQDWQFKANIDANVSLSKAHELRQRHGLSRTLAARRHVEEQSQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB17</accession>
    <name>I4YB17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_46610</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958832.1">
        <property type="nucleotide sequence ID" value="XM_006958770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB17"/>
    <dbReference type="STRING" id="671144.I4YB17"/>
    <dbReference type="GeneID" id="18472390"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46610"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_1_1"/>
    <dbReference type="InParanoid" id="I4YB17"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM21159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="114" mass="13513" checksum="DE9F951A60AF3917" modified="2012-09-05" version="1">MSFSASHRIYVKSLYKRYLKQGLDWYIRRDLWRDYAIEIRAKFEANRNITNPRQLAKVLEQFEQKLAYRKHPDPYIPVLMPGGTKVERNAPPPMFSAEEKKQVIDTLKADKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB48</accession>
    <name>I4YB48_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">WALSEDRAFT_32899</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958862.1">
        <property type="nucleotide sequence ID" value="XM_006958800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB48"/>
    <dbReference type="STRING" id="671144.I4YB48"/>
    <dbReference type="GeneID" id="18471580"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32899"/>
    <dbReference type="eggNOG" id="ENOG502QSK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035539_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB48"/>
    <dbReference type="OMA" id="NCTHNAL"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697906" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EIM21190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="434" mass="47653" checksum="CDB5734513434CE5" modified="2012-09-05" version="1">MFKKLAYLSILGLAVAQSSVTDEASAAKSTDTATECKAYSAPIVKDVQDKFPTIWQPATIVDGDDEAQAKFDEIKQVLPSNIKPKGTMSGDFSDVTPTYDKSDPDCWYTFNKCTKPKIEGLSDDLADLPEPETWGLGFDDGPNCSHNKFYNFLQENNLTATMFYIGSNVMNWPYQAQRGRDDGHQLCVHTWSHHYMTSFDDEGAFAELYYSIQAVKQVTGVTPTCWRPPFGDVDDRIRLIAEGLGLRTALWRYDSNDWRVGATTGAVSKEDVEKNYEDVINAAKNGTFKEEGTIMLTHEITGETMDIFMDMYPKIKDAFKYVAPFYAATNTTNLYVETGDDVKQGETFSEYVKNVYGDDVEAASTTNTNSHPNPTVTGTQGPLATIANPTVASVEGAAASDVTGDGDSGAFSFASFYPVVTISTLMVATLFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB72</accession>
    <name>I4YB72_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_46690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958886.1">
        <property type="nucleotide sequence ID" value="XM_006958824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB72"/>
    <dbReference type="GeneID" id="18472394"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46690"/>
    <dbReference type="eggNOG" id="ENOG502S7GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085447_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB72"/>
    <dbReference type="OMA" id="AWCGRPY"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="218" mass="24076" checksum="710A35099A5AAAD0" modified="2012-09-05" version="1">MKLAHRIPSILSRLQSTHAIPKIVQLYNGSLSDVYRKLKVFSFGSLGAAVAISPIIAILDAPINTAGRVFLITTALGTSVTSTAMINWCGKPYVSSMKVLVNPSNSRQSVELITHSLTLRKLRTVVHDTQWLRRADRPLASWEVSDGELTSTIGEGRDHDVREVIAETFDVKSDKKIGEWFVIWKRSGDSLTAEVQKSGAVDRYFNVDEKSVPSVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB84</accession>
    <name>I4YB84_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958583.1">
        <property type="nucleotide sequence ID" value="XM_006958521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB84"/>
    <dbReference type="FunCoup" id="I4YB84">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB84"/>
    <dbReference type="GeneID" id="18473979"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60487"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816838_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB84"/>
    <dbReference type="OMA" id="NSESSAC"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="142"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="36798" checksum="B1FCD9FB9C4A82F9" modified="2012-09-05" version="1">MSFGRSMEAPMDFDYTNERPSKRPFNNINEASSSRIPFNDKDRRSNLVGSNTPFLFHTTEVKPIENDNNNFDSFKWDVKSSLGLGEVEMADASPKKDNPDNRLKLNSNAVNKMRKKRIRNQQKSHDQPNDNNINYDDLPILLTKYAQTGFNLFLLLGLSSLVYKLVKTILKDVEDKVEYYVQTMNSEASACARSYALNQCDPKTRVPVSEEACIQFEQCMHRDPTTVGIARVGAAAFAEILEGFANEIGLRGGLLIITLLTFFWLIKSVNSRSRYHQQQQSQLIINQEEMEEFQNFLKSNKTKTNKTSKKRWGDGNKWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD2</accession>
    <name>I4YBD2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958627.1">
        <property type="nucleotide sequence ID" value="XM_006958565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD2"/>
    <dbReference type="FunCoup" id="I4YBD2">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBD2"/>
    <dbReference type="GeneID" id="18471549"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32727"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="I4YBD2"/>
    <dbReference type="OMA" id="FGPFYGM"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="29518" checksum="C6706E5C96E75B64" modified="2012-09-05" version="1">MSFSDNPLVQQSSQLTTLQKFELQGKTAVITGGARGLGFEMTRALCEAGCTSIGIFDILSEWGDSAVKELHASFPNVSASFYQLDVRDQKAVVSAVDGIVRDYGGVDILLTSAGVADNIAAEDYPADRFRRVMDINLNGTFFVAQAIANIQIQNKKPCSMVFIGSMSGNIVNYPQPQCAYNASKAAVIHLAKSLACEWAPHNIRVNTISPGYMNTAITDKFDPNLKKTWYERTPMGRMGHVTDLNGAAIWLLSPASNYVTGTDVLVDGGYCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ0</accession>
    <name>I4YBJ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_64596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958680.1">
        <property type="nucleotide sequence ID" value="XM_006958618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ0"/>
    <dbReference type="STRING" id="671144.I4YBJ0"/>
    <dbReference type="GeneID" id="18474943"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64596"/>
    <dbReference type="eggNOG" id="ENOG502QVWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="InParanoid" id="I4YBJ0"/>
    <dbReference type="OMA" id="KIAWGIS"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="51"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="472" mass="51205" checksum="22DB9B509D97D073" modified="2012-09-05" version="1">MSDNLEKNSLETDLEKRGADKTDVNAGDVSAVEIDAFEQNKESSDYQEFRTLGWWQVTALLLAETLALGVLSFPKLASEIGVGPTIIATIGLAFLAWVTGYILVDFKVNHPSVMSFADAGQVIGGPIFKWVLLVGILVNSVFIAASHVNSGGTALSEMSSNARCSVLLGFCMALLGFVFTIPRKYEHTAYASFASCVSIFTACLITIIACGVTRDSWGDSNGEVTWKAFNNPGLAGVINSFTEIVFAYGGHAFIFSATAEMKNPNDFKKSLAVVQIISTAFYITIGVGVYILVGDANVVSPALSIPSHKIETIAYAIAMISIIVAGVIPALNGLKQLWLELFRGKPMLTSNSWKANALWIFMAFITWMLGFLLSQLIPFFSSLLSIISSLTTVWFTYGLSGVIWLADNKKYSYRSPSGWFGNTKKSSMALLSIFIVLMATVITPLGIYSAVESIKEGYREGSYRHPFACRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBR0</accession>
    <name>I4YBR0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958434.1">
        <property type="nucleotide sequence ID" value="XM_006958372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBR0"/>
    <dbReference type="FunCoup" id="I4YBR0">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBR0"/>
    <dbReference type="GeneID" id="18471528"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32606"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="I4YBR0"/>
    <dbReference type="OMA" id="TQMAKDF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="22694" checksum="9B5C230D1AE7F0C4" modified="2012-09-05" version="1">MNPDYDFLFKLLLIGDSGVGKSCLLLRFADDTYTSSYISTIGVDFKIRTIEIDGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDNESFDHVSQWLQEIDRYACEGVNKLLVGNKNDLESKKSVEFNVAKEFAEQLNIPFLETSAKDSTNVEQAFLTMAKHIKDRMGTNSVGSGAGTKSGVKLSSGQQLDQQTSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS7</accession>
    <name>I4YBS7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_28775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958450.1">
        <property type="nucleotide sequence ID" value="XM_006958388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS7"/>
    <dbReference type="GeneID" id="18471058"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28775"/>
    <dbReference type="HOGENOM" id="CLU_1653515_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBS7"/>
    <dbReference type="OMA" id="INCIMIR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697584" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="17208" checksum="AFB4407AFC7EEF5F" modified="2012-09-05" version="1">MKQLLYTLFTLGGIALAQNNNASLTTSEPVDTKVIEVKDCDTTSAVTFENAQGDDIGSVTMKISEPIDSAALTYSIIEQGLTLLSFDGDFCTYLAKSDIDCPLSKGSYKVDFSSDSDIVNSSPSNYTVNIDIHNGDTKLGCADVRFRVPESPETTINISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV6</accession>
    <name>I4YBV6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_38414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958478.1">
        <property type="nucleotide sequence ID" value="XM_006958416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV6"/>
    <dbReference type="STRING" id="671144.I4YBV6"/>
    <dbReference type="GeneID" id="18472062"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38414"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042821_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBV6"/>
    <dbReference type="OMA" id="HIFVCTH"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="267" mass="29746" checksum="CBD7D7A41E6CBDDA" modified="2012-09-05" version="1">MGATDGRSTSQIIEQLNKSPKNDHIHIYICTHGSRDCRCAEAGEPTIQKLREDVLKRGLSDKVHLYEISHIGGHKWAANALVFPSGDWYGNLRPWDSDKFLTNVVNGAIHWPHWRGRLGYDPAKAVKAAEARSLDLDNGGAEVKEAIHAEESDIVKLRFRDAEGETHVVDALLGETLMNVGRRESLGNVEGVCDGKLECATCHMYFPEQDSAEAASFLPEIKDEEDDMLQYAIGYDELRSRLGCQIKVTPELSNWCNKGGVIDLPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC12</accession>
    <name>I4YC12_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_54583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958533.1">
        <property type="nucleotide sequence ID" value="XM_006958471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC12"/>
    <dbReference type="FunCoup" id="I4YC12">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC12"/>
    <dbReference type="GeneID" id="18472680"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54583"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_3_2_1"/>
    <dbReference type="InParanoid" id="I4YC12"/>
    <dbReference type="OMA" id="DVFGDIW"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="509" mass="54585" checksum="34F478592C5A2990" modified="2012-09-05" version="1">MSTRQRQDKATADKHLNILRTLLKEPYNRKCADCNNKDPRWASWNLGIFVCIRCSGIHRSMGTHISRVKSVDLDMWTTEQIQNMVKWGNRSANLYWQAHLKPGHVVPEHKIESFIRSKYDGRKWARNGPLPSDPKMLETGSGGTSASVNNPITQIQKGAPAPRRAIPSSTSAQSSLIDIAPPAAPVPTNRQKTVPKVQINTKAPTNKPPAPPNTVKQAQQKPQTDNGLLDLDLTATSPTNSVKKANKQDIMSLFAAPPPPNAKPIQQPQQSNLNDAFADLTFSSKPPPTQTQSTDALSALWGPNTAAMDSTGSGSSVDFFGGASVAQPPARASTAPIPPAQQSKNLLDDDDWGPTTGANDGDAFDDWGTTSWEAPPPKATATEKKAPPPAGKIELTNSFSAPPVQPTTSLSFSTTTNNTSSFNSFFDNNTNKINLNDSGYSDTSSKFSSGSAFADIPTSLNDIPAPSKLTSDPFSAFQSTSGGSLDLSSPATQKAKSPMVRIFVQSMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC60</accession>
    <name>I4YC60_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958252.1">
        <property type="nucleotide sequence ID" value="XM_006958190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC60"/>
    <dbReference type="FunCoup" id="I4YC60">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC60"/>
    <dbReference type="GeneID" id="18473879"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60311"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC60"/>
    <dbReference type="OMA" id="AYNKCIK"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="162" mass="18074" checksum="48342782BCC572BC" modified="2012-09-05" version="1">MKVFSDVITGDELASDAYPMQENGPFFEIDGQVITVGGEGADIGGGGEGEEVDDNTEQKINVVHSFNLQPTSFDKKSYMVYLKGYMKAVENHLKESDPARVDGFKAEAQEHVKKVIANFKDYEFFTGESMNPDGQVVLLNYREDGITPYFTLWKDGLKSQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC96</accession>
    <name>I4YC96_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_38152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958285.1">
        <property type="nucleotide sequence ID" value="XM_006958223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC96"/>
    <dbReference type="FunCoup" id="I4YC96">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC96"/>
    <dbReference type="GeneID" id="18472050"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38152"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111220_2_1_1"/>
    <dbReference type="InParanoid" id="I4YC96"/>
    <dbReference type="OMA" id="HIILHIV"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="113" mass="12652" checksum="EF999CC2B144CA8B" modified="2012-09-05" version="1">MTSTVEKSINSLIKSYNENTSIRYKLLDSFLVALCISAVIEFLYALAINNSPYNAFLGSFISKVGQFILTVNLRMQTNPDNAKEFQHISPERAFADFVFASLVLHFCAISFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCE7</accession>
    <name>I4YCE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958334.1">
        <property type="nucleotide sequence ID" value="XM_006958272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCE7"/>
    <dbReference type="STRING" id="671144.I4YCE7"/>
    <dbReference type="GeneID" id="18471514"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32544"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867574_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCE7"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="197"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="35214" checksum="A33B00CAC8729EDC" modified="2012-09-05" version="1" fragment="single">MNLDKSSTPSVQGSGSNLSQGHLPQTSQVPFTPKSHPQDRPKRPTMSSNPSFFQSKHNTPQAQSQTHSYSQFNQPSTSSSMRHENDAVAAAAAAASLTALSVLKTPHVMQAASAPNGPGQDVLEQTQHYLSLLVEGFQKQSSKLINEGSGQLFSQAEKIAEKLQQSTASNDKVESSQPQVEGEPNVIYTWKGAGRPRRYFILKALSKSDLDTSREENKWSTQAQNEEILNKAFNEASHVILFMSANKQRGFYGLARMTSKIPNEENANKDQNAPSSDIPARHSNPDTDRKSNENEGIESNSIKTLKSNDEKTWSAPVAEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCH3</accession>
    <name>I4YCH3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tricarboxylate/iron carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958354.1">
        <property type="nucleotide sequence ID" value="XM_006958292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCH3"/>
    <dbReference type="FunCoup" id="I4YCH3">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCH3"/>
    <dbReference type="GeneID" id="18471516"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32554"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCH3"/>
    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="347" mass="37707" checksum="DFDF250507C87373" modified="2012-09-05" version="1">MQNLDNFVDIAQPRYDQSTYLGRVRHFIAAVSPLTLFASSERLAEAQKEVYSVQERIKKSPDGVFVTPEDAHKFWKNKQLVDSSIHPDTGEPIVLPFRMSAFMPTNLIIIGGMLAPNPSLGSVIFWQWMNQSLNVCVNSANANKSTPLSTKELALSYVAATASSVGIAVSLTKGVPKLNVSAATKVSLGRMVPFASVVTAGCVNIAAMRYKEMRDGIQVTTSEIDGKPVKDEEKINLDQPSRVAGTVAVAQTAASRVFTNIPTLIFVPLIQAALTKKGVFKGKRGPMLERIVSLGLAGTSMIIFLPPAIAVFPQKAALDTETVFGRDQDIRDDKGRKVTRVEFNRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCH9</accession>
    <name>I4YCH9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_18590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958246.1">
        <property type="nucleotide sequence ID" value="XM_006958184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCH9"/>
    <dbReference type="STRING" id="671144.I4YCH9"/>
    <dbReference type="GeneID" id="18470774"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18590"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="I4YCH9"/>
    <dbReference type="OMA" id="LNHHDLW"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="357" mass="38429" checksum="DE58B259C27B19CF" modified="2012-09-05" version="1">MPNITTKNLVLGSTAAKPGLETWYGTHLEERTIGDLKPNEVVLKVNAVGFNHRDKWIRQGLYPGIKEGVTMGSDAAGVIIADGDDKDTFVGKRYFVNPSRGWIENKKHSEEPFIILGGCDNAEGVFATAVKVDKKYILPTPEHLTDEQAAAWPLAAVTAWRATFVKAQVEKGHNVLITGIGGGVALQALQFAVAKGANVYVTSGNSEKLQRAIKQFGAAGGVNYKDADWPEQLKKQLPSDHVYLDAVIDSSGGDIVTKVNNLLQPGSPIAIYGMTSVPKTQFTMGDVIKNFELKGSTMGSLKELQEATAFISQHKLIPVVDQPVIQGLENAEEGFQRLVKSSQMGSVVISVGGESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCM7</accession>
    <name>I4YCM7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_28747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958402.1">
        <property type="nucleotide sequence ID" value="XM_006958340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCM7"/>
    <dbReference type="GeneID" id="18471056"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28747"/>
    <dbReference type="HOGENOM" id="CLU_2028513_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCM7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="122" mass="13586" checksum="D8CF98EC4B2A01D2" modified="2012-09-05" version="1">MKRQSDTYLVALRAMEQADAANKSGVKIAIINEGTCSKETLDETIIEGVAAVVDWLFEYKCAKRCARLTHGGGWSATLKVLSDSKRMDPAILNCEQTTKYNCKWNEDGPQPSCGLWYNHDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP6</accession>
    <name>I4YCP6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958049.1">
        <property type="nucleotide sequence ID" value="XM_006957987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP6"/>
    <dbReference type="GeneID" id="18474885"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63971"/>
    <dbReference type="HOGENOM" id="CLU_2795885_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCP6"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="68" mass="7815" checksum="15F5C05D02420F1F" modified="2012-09-05" version="1">MALKYGDKVKFISIDVDELPQLCNRVLGVRFMPVIIAVKNGIKFKHIQSKVPMRLKEFIKTVIIEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCR9</accession>
    <name>I4YCR9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_18275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958031.1">
        <property type="nucleotide sequence ID" value="XM_006957969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCR9"/>
    <dbReference type="STRING" id="671144.I4YCR9"/>
    <dbReference type="GeneID" id="18470758"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18275"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059951_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCR9"/>
    <dbReference type="OMA" id="ASSHVQM"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698792" evidence="1">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="231" mass="25491" checksum="1F1B6926E2E88B82" modified="2012-09-05" version="1">MKLTLILSAFYLSVAHAALFTAKDQVKTLDNASFDKHVLENPYSTSVVSFTADWCGHCRNLVPEYKSAAKSLSGMVNFFNVDCDSDINRPICSRYGVRGFPTVKAFTRGRKAPPKDYNGERKANAISEWAGNQIRNLVTRVSDNEALQPWLDTEKQAPHILVYTNKATTSTLLKALALKYPGAKFGIMKATSRNKDVKKELGLTGELTSPAVFLIRGGSLETTEKYEGLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD04</accession>
    <name>I4YD04_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958148.1">
        <property type="nucleotide sequence ID" value="XM_006958086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD04"/>
    <dbReference type="STRING" id="671144.I4YD04"/>
    <dbReference type="GeneID" id="18475466"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68762"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009043_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD04"/>
    <dbReference type="OMA" id="NLQHWGF"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="394"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="809" mass="89861" checksum="847C763877A80FA9" modified="2012-09-05" version="1">MDDLLKSLNALGVNPPSDSQIPELLNPEEHSTLAKVLAGSADDLIEGAVLSLLENYLRSLKKVEDDHNRSLNAPVKKVKIIPRNALLIRGAKERERLCKDRQAGVGLIRQNQVFDNDIIPASTTPIKDLEYIPIKELEFPRRHQGKYTIVRVITNPNTLFDLHCIVDDKDGSGIPLTLSHFAPSPTAPSDAILPYGSIILIREPYVTKNGIYVPAKSDTRILNKDSDLVKDVQWAFPLEQPSDGKDIDQLMLEANNDNESFWDIIHKLHLVLDSNPVSYEATIRLSDVYFGVQRFGSAYRTAAKAVKLSRDEQQTSRALLNQARAAYDLRLFKKAEVLLKGIQDPELQGEVKRLIFLIGKRRAEREEGIFDVAELFQEKQRSSVPRLDIADYIGPIEVKDIEGRGRGVLATEDVEPGTLMLVGKAVGTAYPSDADERNAKDHTTVMELNFSNKTLHGTAQVLARSRISHAIEDAPFIAKRVLALCGSPTEPLLTEYIKDGFPLTVEEDEAVAMLDSESELPIVDVDPRRVGSVLKYNAFGHASIAGAETPCMLHSLPAIINHSCVPNVASIHLGDVIMSRALVPLKKGQELLHSYVPGTGGGSVMPPSQQERRGELSKHGFICACELCSLDELDGEAKLKERGLMLADIWPRLADRARVLHRAQVEDNKFKTELDQLLEELEEFVVSVENTFSDKRPFELKPELALIRRTLAQLIARRDAEKAIQNELLSLSALGAILAETHNDASNTRKFKQLPRLQPDSAILSMLHIVELLNKTDEKASKSWFETTKWAHDVLVGGGEAGFFARINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD91</accession>
    <name>I4YD91_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958224.1">
        <property type="nucleotide sequence ID" value="XM_006958162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD91"/>
    <dbReference type="GeneID" id="18473876"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60306"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987673_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD91"/>
    <dbReference type="OMA" id="GKCEQIF"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697869" evidence="8">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="77"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="282" mass="31265" checksum="0DF42C8398A25577" modified="2012-09-05" version="1">MVNFAKALLGACALVSTTSAFPAFDGEWEKFYFENFDKAIDPILKRIDQESWNKIAAIEKRQQATFNEDAQRVDVSGEHEYRPPTEGQTRGPCPGLNILSNHGYFDRSGNTNLIESIDALTNVLGMGTDTALALVAYSIAIIGDPIALTWSIGASPGKEVLLPGVLSPPGGIDQSHNSYESDASITRSDSYLSNGDVWSSNTTRFEHLYNLLDDNDPNANFNLDVINKQRAWTHDESVYHNPNFFMRHLQDWSLHLLHTISCPSSFPTIVQNIQKATLTTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDC6</accession>
    <name>I4YDC6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein import receptor MAS20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_32177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957778.1">
        <property type="nucleotide sequence ID" value="XM_006957716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDC6"/>
    <dbReference type="FunCoup" id="I4YDC6">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDC6"/>
    <dbReference type="GeneID" id="18471437"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32177"/>
    <dbReference type="eggNOG" id="KOG4056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090411_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDC6"/>
    <dbReference type="OMA" id="PPPIFQI"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="225" mass="24574" checksum="1C7B7FD9310F9676" modified="2012-09-05" version="1">MRYFTLAAATAVVGFAGYAVYFDYKRRNDTEFRKSLKKAAVKQTKVEKAAAEKSAQDLQLALKAAVLEANIEVEAFKRSVTGAEQGEAYFMQNVGNGEVLASMGPDSELKAATAFFKALKVYPSPVELLMIYERTVPPHIFQLVMQMTSQEVANAQSQKPAEQPKEQEPESKKAAVEEQATEDKSAEDQQKPSTSAPSGTPASAPSDTSSHEWENINGNESNKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDG5</accession>
    <name>I4YDG5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_45105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957816.1">
        <property type="nucleotide sequence ID" value="XM_006957754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDG5"/>
    <dbReference type="FunCoup" id="I4YDG5">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDG5"/>
    <dbReference type="GeneID" id="18472353"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45105"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDG5"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="122" mass="14166" checksum="F1EB982A0C6C8F1A" modified="2012-09-05" version="1">MVQVRAHELQSKNKTDLLNQLHELKGELVQLRVAKVAGGSASKLTKIHSVRKSIARVLTVINQKQRQHVAEAYKGKRIPLDMRHKKTRAIRRRLTPKEQNAKTVRQHKREIHFGRRKFAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ3</accession>
    <name>I4YDQ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957898.1">
        <property type="nucleotide sequence ID" value="XM_006957836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ3"/>
    <dbReference type="STRING" id="671144.I4YDQ3"/>
    <dbReference type="GeneID" id="18475425"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68568"/>
    <dbReference type="eggNOG" id="ENOG502SGA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872099_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDQ3"/>
    <dbReference type="OMA" id="ENTTRSH"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33998" checksum="36AFF8D6C9C1CF38" modified="2012-09-05" version="1">MTNIVLTPPVTPMFNEMKDTPENLSSFVQTFIASIFPPSKKQMMTNLYTPPASPASSQFNTGPHSDLYEFAHYIITRAELCTEAALSALALLARLRRKLPRARAESGPRLFLAAMIVASKGLFDIAYNNPGWYEIAAGCPAIEADFALADINLMERQLLSHLDYRVAVFGDEIIALRRIYMTGQIQQQTSLVKSASTNTSINSLLTPPPSPLDLPVEQVQAEAPPPRPLKSRVRNSIAGPQDIQHYQAFNEPLSIYARRPRAAPLPPLLPVQSSCSMESGPLSAPSDGQLPAYPSSFEQLLRSHRRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDT5</accession>
    <name>I4YDT5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957929.1">
        <property type="nucleotide sequence ID" value="XM_006957867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDT5"/>
    <dbReference type="FunCoup" id="I4YDT5">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDT5"/>
    <dbReference type="GeneID" id="18473793"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60176"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_1"/>
    <dbReference type="InParanoid" id="I4YDT5"/>
    <dbReference type="OMA" id="AIMEHYM"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="269" mass="30358" checksum="FC2E87CFF8DA9384" modified="2012-09-05" version="1">MFRSALFGITRGNLQTRSFSRLSKGQNARPSFRSAFPALQARTMFIQTETTPNEDSLKFIPGVQVMSNNATAEFTEAKSSIGSPLAMRLFGIDDIRSVFYGPDFVTISKQEDSKWNVLKPEIYSILMEHFSSNTPLFRDAAAEEAAGPQDTKILDTDTEIVAMIKELLDTRIRPAIMEDGGDIEYRGFEEDTGMVKLKLKGSCRGCSSSSVTLKSGIERMLMHYIPEVKTVEQVLDQEEEIALDEFSKFEKRLEEKDKKKQDLSQYMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-01-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW0</accession>
    <name>I4YDW0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COQ9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957952.1">
        <property type="nucleotide sequence ID" value="XM_006957890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW0"/>
    <dbReference type="GeneID" id="18471457"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32281"/>
    <dbReference type="HOGENOM" id="CLU_1397317_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDW0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="195" mass="22724" checksum="56957067B2EAB136" modified="2012-09-05" version="1">MNKISLYSSVSVADDGSSHTMKLLNNTARKLIKDIGFNKQVLVAAHPNINAMAIETLYEDPVKQLIDEWREEGLQHLRETSNKSIKDLIQRRLDWNEIQGRDLVMSAYVYDKDFIKTGWSIADEIAYLSKQPVESFYTTRIGIFKAYTTSELFQLQDKHFEPVLDEELGKQETLSRMYNYSDFILRSWKSILDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW5</accession>
    <name>I4YDW5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957957.1">
        <property type="nucleotide sequence ID" value="XM_006957895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW5"/>
    <dbReference type="STRING" id="671144.I4YDW5"/>
    <dbReference type="GeneID" id="18473800"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60185"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="InParanoid" id="I4YDW5"/>
    <dbReference type="OMA" id="QYVAHVE"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="29261" checksum="FFD64BC3A712C33D" modified="2012-09-05" version="1">MDNFKLNRNQSVLTICFNSPVKLNAFNQPMWEALRDIFKSVNNDTQIRAVILIGNGKAFSSGLDMNDAGALLNTTGEVVQTTARLRQHIVDFQDAITAIETCAVPVIAALHGLVLGLGIDIASACDIRYAACSTRFSIKEIDLGLAADIGTLQRFPRAIGNDALARELAYTGRQFNANEALQMGFLAGISCTSSRETVLNMSMGTALAIASKSPVAVQSTKKILLNARDNSVADSLAFTATHNSVALQSGDVKEALSAHLEKRKPVFRDSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE45</accession>
    <name>I4YE45_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957502.1">
        <property type="nucleotide sequence ID" value="XM_006957440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE45"/>
    <dbReference type="GeneID" id="18471401"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31962"/>
    <dbReference type="HOGENOM" id="CLU_2833115_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE45"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="66" mass="7391" checksum="14551E241A888B49" modified="2012-09-05" version="1">MSSEHLADKNEANADKTPAAIDLTEDTASVPDKRVQWSEGDPLPDEPLGDDNEEETKRKQIEDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEC7</accession>
    <name>I4YEC7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guided entry of tail-anchored proteins 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957574.1">
        <property type="nucleotide sequence ID" value="XM_006957512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEC7"/>
    <dbReference type="FunCoup" id="I4YEC7">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEC7"/>
    <dbReference type="GeneID" id="18473682"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60012"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_0_1_1"/>
    <dbReference type="InParanoid" id="I4YEC7"/>
    <dbReference type="OMA" id="AEWIISF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698049" description="Guided entry of tail-anchored proteins 1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24334" checksum="8A672FF985489985" modified="2012-09-05" version="1">MHIAIQLLIAIVISEFIAIVPQDVVQSLVESIYNFTFNRSHLNNQRQLRKDIMKTKKDLTSTSSQDEFSKWAKLKRRHDKLLKEHEDNKQTNTKAQVLIKPFVKVVMFAIPSILQFGVTIANGKRTIIHLPPQNWFGSVLGLVFCLPFSPRGTISATIYGMVVKRVLKLLKQFKQDLGIILFGVSQPEVKKQKGNVSEDKKQDASHTKTPLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED0</accession>
    <name>I4YED0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_37085</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957577.1">
        <property type="nucleotide sequence ID" value="XM_006957515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED0"/>
    <dbReference type="STRING" id="671144.I4YED0"/>
    <dbReference type="GeneID" id="18471993"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37085"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="InParanoid" id="I4YED0"/>
    <dbReference type="OMA" id="IVWIIDC"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="428" mass="47885" checksum="B6CBD4B653DAF335" modified="2012-09-05" version="1">MGLLRLAGRVLAVGILGWSVVLCGVFYFGYRTTKRKYKVLARSPLSSLPRERVPGVTLIRPLKGLDPNLYANLESGFQQDYSNLEIIFAVASDSDPSIEIAEKLISKYPDVPSRILVGETLSGVNPKVNNLIKAFYGAHNDILWIVDSNVQLNSGVCARSVDALQRPSRRGKRVGLVHHIPMAVHPSLDIGAQVERVFVNTVHFKMYTAINELAIDSCVMGKSNMYRRSDVERLEVPSKTSKSVQEPQGSIEAFSRYLAEDNMIARAIWHDLGLDHAITDDIVGTNLGDMSLRQYIDRRVRWIRVRKYMVWLATILEPLTESVTLIPLIIWSLKNLTGARYLELLAFPLFAGWLGVDLAIINTYKYASPHYISPIGNSLPQFIAFWCLRELLAFPIYLMGVFGSNVGWRSGKYKMIAQGEAIPQGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEG3</accession>
    <name>I4YEG3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide binding protein beta subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957610.1">
        <property type="nucleotide sequence ID" value="XM_006957548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEG3"/>
    <dbReference type="FunCoup" id="I4YEG3">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEG3"/>
    <dbReference type="GeneID" id="18475377"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68335"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="InParanoid" id="I4YEG3"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="38390" checksum="8D1E70390574FBAE" modified="2012-09-05" version="1">MSEQQQDIAQKIAAARHLSESLKDKIRAKKEQTADSTLRAMAADIEPLPRVVMKPRRTLKGHLAKIYAMHWSADKRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYNLRGRDGNVKVSRELQAHTGYLSCCRFLNDRQILTSSGDMSCMLWDIESGVRIQEFHDHTGDVMSISLGPNQNTFVSGACDATAKLWDMRSGKAVQTFTGHESDINAVQFFPNGDSFATGSDDATCRLFDLRADREMNQYSHDNILCGVTSVAFSISGRILFAGYDDYNCNVWDTLKGERVGVLSGHENRVSCLGVSGDGMALCTGSWDSLLKIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEQ4</accession>
    <name>I4YEQ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957687.1">
        <property type="nucleotide sequence ID" value="XM_006957625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEQ4"/>
    <dbReference type="STRING" id="671144.I4YEQ4"/>
    <dbReference type="GeneID" id="18473725"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60076"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_10_0_1"/>
    <dbReference type="InParanoid" id="I4YEQ4"/>
    <dbReference type="OMA" id="THPVEHA"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="345" mass="37122" checksum="D47DE7AC7DD165B1" modified="2012-09-05" version="1">MPSSTAPAEIIVDAVLFDMDGTLVNSIAAVEAAWGAVADEIGQPRKSVIEATHGRRASDNLKDWKPDIKDEHLDGEVAKFEQTILDHADQYKKRRDSRSSSQSSSRRASSSSSSRRPSQAQLFGSFTPIDKSRQDSTSQQDRRPSSGTLAQKLQPLSLQDNSAVENEEAVEDEEDEDLGPDMGVKILPGVKSLIDSLPKGRYAVATSGARVYAYGAMERAGIVAPDVTITAEDPRLENGKPHPDPFLLAAKCLGYDCNKCLVVEDSPSGIKAGVASGATTLAVCTSHEKEQIENAGAQHLVRNLEAVRAEQLADGRIKITIDPARIVTDSKSDARTDVGLKDEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEQ9</accession>
    <name>I4YEQ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_54162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957692.1">
        <property type="nucleotide sequence ID" value="XM_006957630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEQ9"/>
    <dbReference type="FunCoup" id="I4YEQ9">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEQ9"/>
    <dbReference type="GeneID" id="18472649"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54162"/>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897733_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEQ9"/>
    <dbReference type="OMA" id="SEELFCI"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="35914" checksum="F1241191F3DFA393" modified="2012-09-05" version="1">MDYSSDNEQEDEVLHCICKSNGLEGLPMILCEGCETWYHLDCIGMEAGDDELVDVFVCKECEEKTGQKTSWRVKCQREGCTHASRLPVSVYCSDACGIYLMSLKLRQYNLHPDSIEMVIPLVINYNKLPWIVFDEENRQMTSLRQSIEYQLEKLSRKNDTIQASINKFSSNISLIEKQEKFLQTVINRANTLTNSLQSVNDTADQPTSKRGPKATKPKQSRGYCGFDYRLLMDDDEWIEFDIDSISDISPTDDQLLCILKDSQCNRHTGWKKLFEYKLQVNKSSFESKIMKLQNKFNNNNLIKRHLDIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEY6</accession>
    <name>I4YEY6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_36513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957200.1">
        <property type="nucleotide sequence ID" value="XM_006957138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEY6"/>
    <dbReference type="STRING" id="671144.I4YEY6"/>
    <dbReference type="GeneID" id="18471967"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36513"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEY6"/>
    <dbReference type="OMA" id="FTSGIWQ"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="5">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="261"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="73499" checksum="79540F8BFD91C32F" modified="2012-09-05" version="1">MKNNDERSPILGEREKESKGVKFGWKALVMIVTTAIIMTVMINPFSQLTVTRKKYTGQTENYKSKVVLDTPWTKDAHTGWDNYPRPQLHRSNWQNLNGLWEYSKAKGTKELFSPPFGEKLPREILIPSCIESGLSGISEYSEHNWFRTLFNVSHNLRNEQFLLNFDAIDYEAVVYLNGVGVGSHRGGYSRFTVDITHAIKEYDNELIVFVRDPTDKLGENIPLGKQRNVHGHMFFAPCSGIWQSVWLESVPRNHIKKVDISGDKKGVLSGVIHTEKPTKFDLQLKDNDTIVAKTSAKSNKPFRLHVNGVKLWNISNPHLYNITIKTEDETVESYVGFRSIEVGIKDGIKKPLLNDEFVFTFAPLDEGYWPDGLYTPPSEKAMQFDVDYLKDIGFSGIRKHIKVEPDLFYHYTDRVGMLVWQDAPSMMHDRTPTSAQIGEFERQFLEIVDSHKNFPSIVTWVLYNEGWGQIDGGIEKQLLDKVVQIDSTRLIDAASGWKDNGYGDFHDVHHYSEPLCGINVETTLVTSPDGKRIEANMEMGGVGHLAPPEHNWPDMRTYKETYEVAGDVPTWNFRTQFILEELRRQIEFTGLCTGAVYTQTTDIESEVNGLLSYDRRFSRPNIDEWKEAINGIYKASNSTYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF48</accession>
    <name>I4YF48_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957259.1">
        <property type="nucleotide sequence ID" value="XM_006957197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF48"/>
    <dbReference type="GeneID" id="18472853"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56784"/>
    <dbReference type="eggNOG" id="ENOG502S1MU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754797_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF48"/>
    <dbReference type="OMA" id="IGRYNIS"/>
    <dbReference type="OrthoDB" id="3365194at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="367" mass="41292" checksum="8F7AAF6E2EBF860D" modified="2012-09-05" version="1">MPHRYTSSAPDVITAIALDNKDIGFIFANKQDEEQSITDNPQKRTASDIASTLLSRSATTRQKSATEKYANLDINRELHYREKEERNQDTQLNERKSNIWSSIKRKVSMTSLASQTLSSVSTATKRTKKSSFSSLQPEVEQPECENEGKRSTESAPEKGTQTSGLSGLRRAATVSGQPRKHPQRKRETQDDSAIDSNGRNLKKPPSSLVLGFFDPDNGIAIGKYNIAHKSTFSKSEKTKKKKKEECDYFYEPNTALAIGKLDDFGSFPESPLKSPLSRSRTTKHKRLSKSNDNIEDGLPVCESQPKRYIRRRKTPKAETTENTSEKSISKTNKGAKIRTKYIQMKQSKPYIVLAKISRVCTCRCNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF93</accession>
    <name>I4YF93_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_27892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957301.1">
        <property type="nucleotide sequence ID" value="XM_006957239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF93"/>
    <dbReference type="STRING" id="671144.I4YF93"/>
    <dbReference type="GeneID" id="18471015"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27892"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038853_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF93"/>
    <dbReference type="OMA" id="REMSTRM"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56443" checksum="D6400B9338AD06D2" modified="2012-09-05" version="1">MGKLSLPIPVTAAAAAAYGSPARAKKMALGFIALITVAVIFFWPEPSKYVVPHGVWRVRQALLIPEVIPWEKETTQSTPVPTYDEPLLSLGGIRRPYLNNTFPPTPNHTIPVFPRQAELSSDAPQPENILFAMTTTAKRAREYSILWQHYMYPNARCLVVLPPSDKSRLEELQNFLERVRRLHCVVQVSKVDHYETRMLSVPNEANKVAKKLGGIKWLCIGDDDTFFTDIRLVQRMLQKYNPDDDYFIGAISEGADQRQIFGRQAFGGAGLFMSPPVMQKMANQYEDCVREANIYWGGDGKLTKCAAYVLGVPFEEVLTIEPGMHQFDVPGSGAGYLQSGLPFISMHHFINGWTHLVPHHLPNRISDDWYATGLIMKAAKFLGGDNLFRRIMFDGGKTLLCLGHSVILYEHAQSPSDLAQIEYTLGPSGFRFIEQLPVRPEPPKRNEYFISDIRVESPERAIFWFEDKEGQRLRLVWDGENGSIDLPAVQQPKNKWIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFC3</accession>
    <name>I4YFC3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_63298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957330.1">
        <property type="nucleotide sequence ID" value="XM_006957268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFC3"/>
    <dbReference type="GeneID" id="18474829"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63298"/>
    <dbReference type="HOGENOM" id="CLU_2308235_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFC3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="100" mass="11091" checksum="F2E750690F6C3472" modified="2012-09-05" version="1">MKWLCLSTVAKCKDVAANKPEIMTTRRRSVKTSSTNKKFYNSIDIRTRKAQQNTEQRNGDNGIAHVEILAGTPNLLKALFSTHSGSVSNWDLLAVQASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFT1</accession>
    <name>I4YFT1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_16207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956858.1">
        <property type="nucleotide sequence ID" value="XM_006956796.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YFT1">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFT1"/>
    <dbReference type="GeneID" id="18470690"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16207"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001524_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFT1"/>
    <dbReference type="OMA" id="AMHITNL"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="3">
        <location>
            <begin position="889"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1292" mass="145349" checksum="318B96DFFAB920DF" modified="2012-09-05" version="1">MTQRTSSHNLLSDASEVHRNEVGVQLLTPSLRRQVYPRDLEQPHPSYVNIALEHLEKHNLASGKGSTLPQTSFTLPPLQGPDLDHHFWRIGSEVAEPYLGLSKDLCSRKLPTMPDYWVTDTHGWTVYDSDGSYKCIENGPSTESMVVFDVETLPHISQHAVMAVAASPTHWYSWISPYLTGHSTSTEHFIPLGESDSRSRIIVGHNVGYDRARLAPEYAMEKSTNRFIDTMSLHVAVRGMSSPQRPAWVAHRKEKQLERDHAREASQTVRNILTEREDPELQKSLMKYELEEKAAQEAIDKAMLQVSVEDTGNSQWQDIATSNSLNNVYELYNPDKPRLDKQTREYFMDESSNAETLKPELQNLMQYCALDVQATHDVYQKVLPMFLERCPHPVSFAGMLGMGNSFLPIDQSWKEYIKSAEGKYKELTDNVHDNLGELAEMAKTKLDDGSWKDDVWLSQLDWTPKRARRARKTTSKGNKTDIEIPTWFSKMLARRTDSMLSSPSLKASILPYLIQLKYLGHPIIFTTTLGWAAKVPNKDDTLQSQAEQLKDNDARKYEEDNYYFVKVPNTLSKSFIVGNVISKAFEGLVKDGRLTSVLSKEELLGVFSGGDGKSETLLNKIMLESYLNNNINELSELDWSPTRLTSASHKKLLHASELAGVGLNESFGKPIKSSTPAENLNSSLMQPKWYWDLEGKHRREDGKIEVSTRSKLSPILLKLRWLNYPVFSSRKHGWVYRVPRSDIINEKHTTRQPELAFKHPSDATLSEATKEFAFYKIPHKDGEEYNVGNLLSKGFIHAMESGVLTSEDNTAHAAMDLNAQCSYWISSRERVMKQFAVYDGSDGVNMGLGGKQSKRGMILPEVIPMGTITRRAIEKTWLTASNAKKNRVGSELKAMVRAPPGYAFVGADVDSEELWICATLGDAQFGVQGATAIGWMTLEGTKSAGTDLHSVSANILGISRDQAKVFNYSRIYGAGVKHAVQLLLQSNPSISESEAKQRATELYAATKGKTIRDAFGKKFWYGGTESYVFNKLEEIALSDQPRTPTLGCEITAALSKKHLPASGSNFMTSRVNWVVQSSGVDYLHMLIVSMEHLINKYNIKARYLISVHDEVRFLVDEKDKYRLALALQIANLWTRAMFAFKLGMDNLPMSVAFFSGVDIDQVFRKEVDMDCVTPSNTTAIPPGECYDIEALLKITNGTIKQDGRKMEDRPPVNEPAPDCRFFTQSHRPPTVHFLKAQSASSVSQIKMLERQLRETPTDVIRTPGKTTGKKKTSQSPRGPVRKVNIIRKPIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG19</accession>
    <name>I4YG19_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_36163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956957.1">
        <property type="nucleotide sequence ID" value="XM_006956895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG19"/>
    <dbReference type="FunCoup" id="I4YG19">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG19"/>
    <dbReference type="GeneID" id="18471948"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36163"/>
    <dbReference type="eggNOG" id="KOG1659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_9_0_1"/>
    <dbReference type="InParanoid" id="I4YG19"/>
    <dbReference type="OMA" id="AHKQCIE"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="15424" checksum="5173B1C950079E03" modified="2012-09-05" version="1">MASTSDKQQIQLKKQKNTKFPVARIKKIMQMDDEVGKVAQATPVLISKALELFMQALVDETLKVTQDKGAKKMTAQHLKQSIEKTEQFDFLSEIAEKIPAPSADDNQPKKRKPRKKSVKQEDQQEDLKQEAQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG42</accession>
    <name>I4YG42_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956979.1">
        <property type="nucleotide sequence ID" value="XM_006956917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG42"/>
    <dbReference type="GeneID" id="18471336"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31614"/>
    <dbReference type="eggNOG" id="KOG3702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_960437_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG42"/>
    <dbReference type="OMA" id="NQVTSEM"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="290" mass="32833" checksum="B77F3F2E3F5C9CC7" modified="2012-09-05" version="1">MSDLQKFVEKVLIEHQLGDEDLQLISEYIVVMITNQKNAEQVTSEMCDLIGDRYNATITQQIFNEINKEQSTEKPVNEIEQPKEEKPAPVEQPVQAESQQPDQTEVPQQVETSQPMAAPSTSTKRSAADASLDDLIFGNNQANQGNNYRQNKRRPQENNNQTRHPRLDPATYKLSKELTTNFLESNPQMKKQYEAYNFQDRTNFERQLLQQHFMTMQTAKVMQEQFEKMQKEAEEKAAQRLGGGVSTRGSPARGGFRGRGGAPRGGFSQRGNARGGFANKVSMLSILLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD8</accession>
    <name>I4YGD8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_36342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957067.1">
        <property type="nucleotide sequence ID" value="XM_006957005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD8"/>
    <dbReference type="STRING" id="671144.I4YGD8"/>
    <dbReference type="GeneID" id="18471957"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36342"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGD8"/>
    <dbReference type="OMA" id="NEFIPPW"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="53"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="567"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="692" mass="78564" checksum="EB9E42AAF6F40748" modified="2012-09-05" version="1">MVAADWSDIRIDAKNGTFVDQHHRNCYPRGVNLSGGSKLPSNQSATNHEDFYNWKAVSFVNKPFPIENAEYHLNKLKNAGMTFIRLIVTWEALEHSGCGIYDYEYMDYLATLCSLMEKHGFKIVIDAHQDIWSRMTGGSGAPGWTVELAGYDVRALDDTAAAYLYPIRSQKGPNWSAQPGDGLEHGVWPSGYQKNSAATLSTLFWGGSTFAPSFVIDGKNIQDILQEAYLNAFAELSKRLESPAIVAFELMNEPHRGYIELDNFECWNYNTDLHIAHMPTPVQGMALAMGHAVTVDYYTRTFPFPTRKSGVRKISPVRKAYKNDAVCPWLREGVWAYSTDKSKPVVLRQDYFKKHPLTGKTVEWYHDFYMPFAKKFYEKCANGRWCVVEPIPNEFFPNIPAEEQPKKLIASPHWYDLNALFKKEGTWWSVNVQGLARGMMIWNALYIGYGGLKKNYAKQIGRLVHEAKKNLGDVPVFFGETGIPMDLNDGEGQKKGMWKYHEWSLDALICALEKHATSFTLWNYNPDNINDGGDVWNGENFSLFSKDAIKGDDSVTDGLRIPEVWIRPYASKVSGEPLEMAYNRGEKKYTLRMRPREGVSEIFIPAAFFDAVEVVIDGGSYEYVKSDQTVYWKTESSNDVVEMSIKNPKHKVPETFFSMYGPLIASLLFMLAAVVARNHIQPVLLALKEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGJ9</accession>
    <name>I4YGJ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_36429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957124.1">
        <property type="nucleotide sequence ID" value="XM_006957062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGJ9"/>
    <dbReference type="FunCoup" id="I4YGJ9">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGJ9"/>
    <dbReference type="GeneID" id="18471962"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36429"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156007_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGJ9"/>
    <dbReference type="OMA" id="QWAIERN"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="104" mass="11451" checksum="95CF6818F47D95D4" modified="2012-09-05" version="1">MRTSGVQYGGMPTGKTYMGWWGAIGSPKQRGITQYGVSAFTQRPFAGALQGYIFNGYKRLAKQLPYSGIPFALGYGIYYWATTKHEFLNSKAGHIEALEKGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH62</accession>
    <name>I4YH62_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Surp module</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_62673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956691.1">
        <property type="nucleotide sequence ID" value="XM_006956629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH62"/>
    <dbReference type="FunCoup" id="I4YH62">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH62"/>
    <dbReference type="GeneID" id="18474776"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62673"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013259_1_0_1"/>
    <dbReference type="InParanoid" id="I4YH62"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="612"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="74811" checksum="D049186DCE6A99D8" modified="2012-09-05" version="1">MDGNRSTPKIPPPEGMIYPPPDIRSIVDKTANYVANSPHGPLLEEKIREKERANAKFAFLNSADAYHGYYRWKSERIKAGDKEDIFTKSTLSTPSISQTPSFMPSKPIPKEPIGHEFTIEIPDNALAIDLDIIRLTALFTARRGKSFISMLGGRENRNPQFDFLRPNHSLFGLFNNFVEQYLKVIKGTSAPLDEEFDKLSLSQKKSKLVDNAKSRSEWEAYKREGLKKREQESEKETLAFQSIDWQDFVVCETIEITETDKVLELPKPLSIKEVRNLAMAQKRMTSLLEEEVVTNPNTGAQDVDVVMEAKQPQSNTEQSLSQPSATPAVSNAPEGMKIKTNYVPKSQKQQQQIPQGYSRSPISGALVPNEEFANHLRIELLDPKWQENKEYAESRRQASVLLQQGADVASSLKNLAQGRTDIFGQDMEKAEQRKREAEAAAQEVKRKKEAGVWDGHTASAETVAQRYQAQATSEVQAERINQTLGINQPQQATTAGPQVNSYGDVYDPSGVSFSAAPSGPSAPKFHMPNTGNVRTAEQAEIEPFSNPSKRLKVQKLPEGQYYTEDEWLSYHPDGYVSLTVKLPVDTNNPEWGLDGSVIKLSPTPLTSISGVIREYISEALEAKNGEGKRGPPIGRMRLDFGNITLSNSKSVASYNLDDGDQIKLLVRQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH86</accession>
    <name>I4YH86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_56431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956714.1">
        <property type="nucleotide sequence ID" value="XM_006956652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH86"/>
    <dbReference type="STRING" id="671144.I4YH86"/>
    <dbReference type="GeneID" id="18472809"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56431"/>
    <dbReference type="eggNOG" id="ENOG502S560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950628_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH86"/>
    <dbReference type="OrthoDB" id="2333993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="293" mass="33731" checksum="A8795BEAA2D1FD98" modified="2012-09-05" version="1">MEEINPYLDEIYRSNGLIYSDLEQAGESPSSRSNPSTSKQSIEPKQSNKEMSYPCEYCDKCYSGKHGRSILRRHLSEKHDIPLRDQPRRSRWDTDSRRPKSEQERRDRMLASKRRWAFKKRHGKSKEDVEQEVETMNKYENASTTSNTSFTSDIPSTYNQSLTPKRVKVEEENEDDYPTTLPPLIYPTNAPPSIPRFEVFKEESTPFKLPSITPFRQSSTHNFFANTPPSTLFKDKGNLQMSSPANPDLASKLGLAPTPKNDMFSLNNYQETPVKIRSKVPSLKELTTPNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHA5</accession>
    <name>I4YHA5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956731.1">
        <property type="nucleotide sequence ID" value="XM_006956669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHA5"/>
    <dbReference type="FunCoup" id="I4YHA5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHA5"/>
    <dbReference type="GeneID" id="18473429"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59572"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="I4YHA5"/>
    <dbReference type="OMA" id="IGREFRF"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="38689" checksum="9BEC7A12EF64E1A6" modified="2012-09-05" version="1">MTALILVTGANGFVGSWTVLKLLEDGYSVRGTVRSADKGNYLVKTLHNLLGEEKASKFEYVIVEDMRSIGVFDKITEDVDGICHISSPFHFNAIEPSDLIEPAVGGTLNVLNAASKSKTVRRVILTSSVAAVVNPEPHTPRMFTEEDWNEHSAKECEEMGINARAQSKYRASKTLAEKAAWEYMKKKTPSFSLSTITPPLILGPLIRQADRADALNTSSLWAYSFFNGSKIDDDPASFSNPMTNLADVRDVAQMHVDCLKVAEAANERFVCVCDGGFKTWQDMLDAVHEGVNGEEVAKRVPKGNPGAGKLVNQSWYTNRKAKSILKSTFIAYEQTCVDTYKSLLEYEKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHK5</accession>
    <name>I4YHK5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_31517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956820.1">
        <property type="nucleotide sequence ID" value="XM_006956758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHK5"/>
    <dbReference type="GeneID" id="18471319"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31517"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHK5"/>
    <dbReference type="OMA" id="NGFMSTW"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF56">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47624" checksum="BE8111B5163F246E" modified="2012-09-05" version="1">MFDCIGNLGAGGFGSVKAIATANALVYALMTVGILLSAPIISYVGLKPVLILGCAFFCVYGAALYYNSIAHNDGFLIGGSVLCGISAAAFWATEGTIFSSLPSNDDRGRYLALWGIAKNLAPLALGGSISLGFNVHSYESGNISPDVYIVFFSLMAAGFAISFLFPNPNNIYRRDGSKVEVRKTDGFFTEMTRTLKAFREPRVFMLLPLFFMSYFYYAYQSNFTSLYFNVRTRALSSFVSPFGAIISSTMMGFFLDSKRWSEKTKGMTMLGILFVLEMGLWTWIAILRSIYGDNDSIGLDFDGASSVFNRAFPVVFFMNFIGQGSQNYLYWVVGHYACGVNNLSTYVCILRSFEALGQTVAWAISQTTSTTSPVHIYINFIGLFVSILISIPVISKLQYYEKDENEFINYNLSDQESPKLSLDEKADKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ2</accession>
    <name>I4YHQ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956172.1">
        <property type="nucleotide sequence ID" value="XM_006956110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ2"/>
    <dbReference type="FunCoup" id="I4YHQ2">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHQ2"/>
    <dbReference type="GeneID" id="18473237"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59231"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHQ2"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="346" mass="36105" checksum="E6FB1F362D953E8C" modified="2012-09-05" version="1">MTSLITMNIPALRSAFSATSRRTFSTSRAKLDALVYLEHRDGKINPGSLSALTAAQKVDGKVVGLVAGSENVDSVVEEAKKLPVNKLLLAKSDIYNHHSPSTLAPLLKSIVENDSAITHLFAVHSAVGKNVLPRAAALLDTSIIADILNLENGGTEFTRGIYAGNAISTIKSDEPKKVVTVRGTAFDAAVAGSSEVAVEEIAAVDAKDHAPYVSSEMTVTARPDLGSASRVISGGRALKSAENFNQIIEPLADKLGAAIGASRAAVDSGYADNSLQVGQTGKIVAPELYMAIGISGAIQHLAGMKDSKLIVAVNKDPEAPIFQIADVGLVADLFEAVPEITKKIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW5</accession>
    <name>I4YHW5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956233.1">
        <property type="nucleotide sequence ID" value="XM_006956171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW5"/>
    <dbReference type="GeneID" id="18473257"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59262"/>
    <dbReference type="HOGENOM" id="CLU_2851432_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHW5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="65" mass="7042" checksum="ED8283E5C73F49EC" modified="2012-09-05" version="1">MVLSAFLSLVNYFSIDILHGESGVARCTGTVNTASGAERSESPHNHELRYLKTLKSTEAVSQEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY4</accession>
    <name>I4YHY4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956251.1">
        <property type="nucleotide sequence ID" value="XM_006956189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY4"/>
    <dbReference type="GeneID" id="18473259"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59268"/>
    <dbReference type="eggNOG" id="ENOG502SS8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122015_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHY4"/>
    <dbReference type="OMA" id="TWKEIWE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033579">
        <property type="entry name" value="TMEM128"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20479">
        <property type="entry name" value="TMEM128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="17304" checksum="022F6555BB7CB680" modified="2012-09-05" version="1">MASLTPASQSPLNVNNFLKQLKWVVTGSFLAYITDLRVNLYALLISHGWPSTLSKVSIALLGLTTLLFLYLLIWLPYIRNTLPDYQHWSSEAHTKSIIPILTLSILIGWSSLFIAFASVHSIIFSFFITCSVYLLVFGSVGLIPTKRRLPSKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI98</accession>
    <name>I4YI98_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_59343</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956356.1">
        <property type="nucleotide sequence ID" value="XM_006956294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI98"/>
    <dbReference type="FunCoup" id="I4YI98">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI98"/>
    <dbReference type="GeneID" id="18473298"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59343"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="InParanoid" id="I4YI98"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="62"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="473" mass="52542" checksum="592359CA90EF043B" modified="2012-09-05" version="1">MQTQSKDLPTKLERIGAHSHIRGLGLDDRLEPIPSAEGMVGQLRARKAAGVIIKMVQESKIAGRAILMAGPPSTGKTAIAMGMAQRLGDDVPFTSIAGSEVFSLEMSKTEALTQAFRRSIGVRIKEESEMIEGEVVEIQIDRSLTGATKTGKLTIKTTDMETVYDLGNKMIDSLNKEKVMAGDVINIDKSSGKITKLGRSFTRARDYDAMGADTKFVQCPEGELQKRNQVQHTVSLHEIDVINSRTQGFLALFSGDTGEIKPELREQINSKVAEWREEGKASIVPGVLFIDEVHMLDIECFSYLNRALENELAPLVIMASNRGYARIRGTKYTSPHGIPVDLLDRLLIISTKPYEREDILKIVQLRAQEEDVTLDEQALVALEKIGVECGLRYALNLIAPAQLCAKRRKSIEDVVQPEDLQKAYNYFINDKRSVEFLREQGQLLIFNEGAITDQAKDWNSLQNIPNAEPMNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIC4</accession>
    <name>I4YIC4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956381.1">
        <property type="nucleotide sequence ID" value="XM_006956319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIC4"/>
    <dbReference type="GeneID" id="18473307"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59357"/>
    <dbReference type="eggNOG" id="ENOG502S7BI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438882_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIC4"/>
    <dbReference type="OMA" id="LHIFIVN"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="562"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="623" mass="69598" checksum="D909FF6918634635" modified="2012-09-05" version="1">MKSGDELLKRGKLDATLDSDKRYAYFDERLGVTVRLEIDGNESKSTVEDLFNSLLVTVSLNYVDSEDEGSNPLRQTPQTAFGPIPGPATPSPIPEGSEQFSKSQGVFVSTTLFEGSEKSLTKGEVNWVCNWIVNVDAVRVRMNFSKPSAALTSTITLRDKQNESKSVESTVNCKNTEDDDDIIDDWDSIDLLEGVSPLLRLPSSRLTQTYQNDDIPSHNIPEKTLKRSCRIVIPISSAFSVRMRAVNIPSLLHRPEDDKPHLVLGLELENCIRNNFMVTDVGIRMKEASIADDNDELIGRRHELTQSDLPAQLQAGEQHNLIYIIVFKQKEVQPVVDKSRQSKEFNRPRRFNVRINVLAHTENGSVFDMKWNSFIDISNALVEDWKKYNNTTDTVTARPTSMNTNSSKHMSGPVAGNRRFTLTNLQHASEMAAATSRQQQQISEESDSESTDSTTSNLGSVVSSKENVLVSVSVLKPTKSIKLAQRSPSIFSPQINTPAKESADLIKTFDIFPVELFLFNKSTLARRFVVAFPNHNQINSRNQSMSFEERLLDDIPNPNCDAGIIPLENFVRFGPLQPGSCQSVNVNFLALREGVHTIDQLELYDPDTGFSSRLKNVSTVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE4</accession>
    <name>I4YIE4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956401.1">
        <property type="nucleotide sequence ID" value="XM_006956339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE4"/>
    <dbReference type="FunCoup" id="I4YIE4">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIE4"/>
    <dbReference type="GeneID" id="18474747"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62405"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="InParanoid" id="I4YIE4"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="145" mass="15554" checksum="DA27B3CC2F0A0656" modified="2012-09-05" version="1">MSRFARQLSTSARTMSSSFKVTSTPNAPSAVGPYVQAITHNGVVYASGCIPLDPQSMTIVGEGSIEPQATQVLKNLKNVLEASGSSMQDVMKTTCLLKNMEDFVAFNKVYEGAFAPHKPARSCFEVARLPKDVLVEVEAIAAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YII7</accession>
    <name>I4YII7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956442.1">
        <property type="nucleotide sequence ID" value="XM_006956380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YII7"/>
    <dbReference type="STRING" id="671144.I4YII7"/>
    <dbReference type="GeneID" id="18473335"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59407"/>
    <dbReference type="eggNOG" id="ENOG502RYE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007340_4_3_1"/>
    <dbReference type="InParanoid" id="I4YII7"/>
    <dbReference type="OMA" id="HRESSQW"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="159"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="702" mass="79095" checksum="5FEDD217255A383E" modified="2012-09-05" version="1">MKGATMSRQALVDNTSNLLLRIEQLEKSISTQGGVIPDAPTKLITSATAVFNSPDSTEAANAIRPPIETHDEDFAESFGALTVTKEGSRYVGPSAGSEWLQNDSLVDREQEFIDERGQIGESPDSPPTDFPFSAANNAEIIEELWLKLPDRSRAMQMVDVYYRTCSCLYNCVQREVFENDLNTLYNQPDAHKLARLYMVFALGVYFDVNLSTDHPDSQRYYSYSKALLSAGDFLVKSSIPAAQTLHMMGIYLLNRNRLSGADSYYPLLGVQLRITRAMGLHRDGQRWGFQGNDLNERRMAFWETQTMDVFQSICFGRPYSTQLRHVDCAFPLDEQARNYNGEGYGYQTMRYSLVRLLCKISDEIYSVKPPTYDTVIGLDREIRQYEKNIPLHLRCKAASVVRNSSNYPVNDSVQEPVSEELLLQQHTLAMNVNECLLYINRRYFAHALKTHPENPLKSPFSQSFVAVMECCRVMVALGHSIHRLLPDLSSRHFFFFYHLFSFGVCSAASCIISPGSSMASDAWKDLNSITDLCALPTAGKRANLFVPALNKLRERALIRCKAHIEAREHKEDDHDNEHMVMLGLGSRFVNTSPTSDKPQTTFNAPLRSRRNTLPSDAIYTELLKQTEGTASSTEMFNSLWQVQQEGTSNLALNSGINEYNNIFPNNLDFLGMDSVLSSTSNAQPESSNHSTDWNTLLQSMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX1</accession>
    <name>I4YIX1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955754.1">
        <property type="nucleotide sequence ID" value="XM_006955692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX1"/>
    <dbReference type="GeneID" id="18474679"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61743"/>
    <dbReference type="eggNOG" id="ENOG502SFX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2252144_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIX1"/>
    <dbReference type="OMA" id="EMKDGMD"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="104" mass="11024" checksum="BE27CBA4B1A55051" modified="2012-09-05" version="1">MDKIQDKIQGAWKGFHGTGETIRGTFNETVDRAGDQIAGRPAGSVESKSNNPGTAKKGINEFKDGFDKLTSSSNTGGSQEASVEVPEAQQPQGHSVPPKLPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX7</accession>
    <name>I4YIX7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_53099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955760.1">
        <property type="nucleotide sequence ID" value="XM_006955698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX7"/>
    <dbReference type="FunCoup" id="I4YIX7">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIX7"/>
    <dbReference type="GeneID" id="18472603"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53099"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016864_3_1_1"/>
    <dbReference type="InParanoid" id="I4YIX7"/>
    <dbReference type="OMA" id="INLICRI"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="454" mass="50149" checksum="8E6F8309847F944C" modified="2012-09-05" version="1">MSYKSSANDVPLGSRRKYGNNPPFEEERGRSEKRMREMPPPAQPDQPRKRKSRWGDSKDSGAVLPTAIYNANASQKSLECYAAQMRIEEINHKLRTGNIVPPEAERSPSPPPSYDSWGKRVNTRDQRYKLKLERERIKLIDKVMKMDPSYRPPSDYNQARRSTRPTEKVYIPTHDFPEVNFFGLLVGPRGNSLKSMERQSGAKISIRGKGSVKEGKGRPDSMDASSDEDLHCVVSADSEEKVRKCVRLINKVIETAASTPEGENDHKRNQLRELASLNGTLRDDEGQICQSCGAAGHRRWECPEGENITTQIKCSLCGQSGHLSSDCTVNPGQAAQIKGATNAPGFDSEYASLMAELGEGGGASKGMIEASSAQTVPGSQMSYVEKWQSEGKNLPPWRNPEIWASANAQTGGGYGGAVSYDQNAFNQGYSYDQSYGQYYGAAGQDGYQQQYGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIZ4</accession>
    <name>I4YIZ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_30743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955775.1">
        <property type="nucleotide sequence ID" value="XM_006955713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIZ4"/>
    <dbReference type="STRING" id="671144.I4YIZ4"/>
    <dbReference type="GeneID" id="18471169"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30743"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072390_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIZ4"/>
    <dbReference type="OMA" id="FRYFRAP"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24466" checksum="0B3AF0926AEA58AC" modified="2012-09-05" version="1">MDGRQISVYKPYEKDGNRLEYPESYYEPTSSELARAHTATSKRLESQYEGPLKTKAIREKEERQRKAKWPTTKIRIKFSDRSIIQSEFNSVDQIGRVYDFVKLALDDKYINEDFLLYQSPPRIEFKVTEQKSLIDLGLAPSSILMIKFANESLNATNSKAPLKGSLVESADSLPTPPSFDTPMVEQKEKKKVETEDKKEKKIPKWLLKGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ62</accession>
    <name>I4YJ62_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955838.1">
        <property type="nucleotide sequence ID" value="XM_006955776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ62"/>
    <dbReference type="GeneID" id="18474687"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61832"/>
    <dbReference type="HOGENOM" id="CLU_2607860_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ62"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="79" mass="9411" checksum="674859BE8AD83B47" modified="2012-09-05" version="1">MHVVDEKDLKQEYEEHEVAPDGVLRHGQTVDLETYSNDDEEFGGYENRKKMERKLLWKTDARFAIMIIKTMSRRLVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ98</accession>
    <name>I4YJ98_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955872.1">
        <property type="nucleotide sequence ID" value="XM_006955810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ98"/>
    <dbReference type="FunCoup" id="I4YJ98">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ98"/>
    <dbReference type="GeneID" id="18473155"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59067"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070944_4_0_1"/>
    <dbReference type="InParanoid" id="I4YJ98"/>
    <dbReference type="OMA" id="THEKGHF"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="99" mass="11123" checksum="A1BC1D8D4FB12206" modified="2012-09-05" version="1">MTGNSADDKPKIPKAVIKNVDMSQELQQSAIDITSNALEKYTVEKDIASFIKKEFDRVHGATWHVVVGKSFGSFVTHETNHFIYFYMGTSMAFLIFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK4</accession>
    <name>I4YJK4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955971.1">
        <property type="nucleotide sequence ID" value="XM_006955909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK4"/>
    <dbReference type="GeneID" id="18473182"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59116"/>
    <dbReference type="HOGENOM" id="CLU_898850_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJK4"/>
    <dbReference type="OMA" id="HASFRPQ"/>
    <dbReference type="OrthoDB" id="10543678at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="33564" checksum="392D85E185C92F57" modified="2012-09-05" version="1" fragment="single">MQFKLTKKVVKRQATLPEGFEGSGLKMAGSSSSSNSDTTDNEKSPDSSGIQFDEDADDVINLPQDPPKSDQPQIDQHQHGNENHNEYSSALAPSLTIGIVAVLIIAAVAIRYIKRKKRIEALGSDPKKDNEKCINTPSDANSLIKDREFGTPPPVYTILPRSSSLNMTKSSNSYGDMFHSVNTMHDLPPTPGPADYEDEQMEGLEPPRRPYVQTPPISPIAPIMPRSSSLGTVSADNHMPRSSSIGSVRSIGERVPSPIERVESPFSRASSRASHASLPMPSVTPIQLIKSPNQVTTPSSNHLMTSPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJX9</accession>
    <name>I4YJX9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956086.1">
        <property type="nucleotide sequence ID" value="XM_006956024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJX9"/>
    <dbReference type="FunCoup" id="I4YJX9">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJX9"/>
    <dbReference type="GeneID" id="18475209"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67100"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJX9"/>
    <dbReference type="OMA" id="WSFYYWF"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="303"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64573" checksum="592DA894A624B805" modified="2012-09-05" version="1">MSSLQQFNQLRVQINQEFWHALSNFKVNDQKLDDSPVAINAGYLPSRQTLDRKTGELVDSGSYILIEGIDTPPPNCIPVKGIVKNYNTLEEFKKCDKVRLFEQSLDLIKKATTVDDLNRILLITFSDIKKFRFHYLAATPAIIDKDKEAQWYGKLTECDSNLASEIQSVQPDDSWCWITKKQEGKQYGARVDDWKDFYNNDDEFTLAFIDSSNSDTPGWILRNLLYYVVTKFKANNLNILASRSTGGLYGTLSTKSTYTQTTGVGWDKNAATGKITPKLVDLSASMNPNKLANQAVDLNLKLMKWRILPELNLEKVSNTKCLLLGAGTLGCYVARGLLAWGVNTITFVDNGRVSYSNPVRQPLFEFEDCFSDSHSGAPKASSAAEHLKKIYPDVQSSGHSISIPMPGHPQQRSNVEKDINTLEELVKQHDCVFLLTDSRESRWLPTLLGKVHNKIAINAALGFDSYLVMRHGTSINKLGCYYCNDIVAPTDSLSDRTLDQMCTVTRPGLAPMAASTAVEMLASILQHPDQHNAPSSRGEEQGSILGVIPHQIRGILQDKLMTAVQPVRMSLLTGIMRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK26</accession>
    <name>I4YK26_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_35011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956126.1">
        <property type="nucleotide sequence ID" value="XM_006956064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK26"/>
    <dbReference type="STRING" id="671144.I4YK26"/>
    <dbReference type="GeneID" id="18471898"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35011"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="InParanoid" id="I4YK26"/>
    <dbReference type="OMA" id="MVKWKVN"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698240" evidence="6">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="485" mass="53507" checksum="8123B0302BDF6243" modified="2012-09-05" version="1">MKTSTLFPLVAALIVSVFATDALNLPLGDTLEECLRASNITVIAPDDTLYDTVRQTWNSRIQYSPKFIVQPNSTQEVQHSVRCAATHSNVAVTVKSGGHGYAGYAIGGEDGDLTIDVTNFNNIDVDTESSLVRAGTGNHLWDLYKTIYEDNLVLPGGTCPQVGIGGHASFGGYGPLSRKMGLLLDRIVEAEIVYANGTAANVTQGEDIFFAITGAAPSFAIVTQFTFLAERAPENTVIFSHSLINRTAESAADAFDAFVSFINGNVTNEFSAWITLGPGSFELNGMYFGSQDDFEVIVKPLFEGVKLSSNDSQDVSQTSEFIEMYKQIYGDFSPVAEPKPFYSKSLMINEPLTVDQSLSFFNYLNNAGAQAKNQGYDWYIIVDPYNGVIHEKSTQERSFAHRNTLLTFQFFAEMGESEETLFSLVDGMVDSITELPKAAYPNYVDPRLINWQELYYGPNYLRLQEIKGVVDPNNTYRFPQSIEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y516</accession>
    <name>I4Y516_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_49590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960891.1">
        <property type="nucleotide sequence ID" value="XM_006960829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y516"/>
    <dbReference type="GeneID" id="18472502"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49590"/>
    <dbReference type="HOGENOM" id="CLU_2948411_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y516"/>
    <dbReference type="OrthoDB" id="3362758at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="60" mass="6964" checksum="4655CB50E17418B7" modified="2012-09-05" version="1" fragment="single">QIDRTKAEPQQIVATRLLYCLQYPVPIQVVCKRFTPAIHHLSFVVNTFNSFQSNAQNYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y547</accession>
    <name>I4Y547_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_70886</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase C19 family. UBP8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960873.1">
        <property type="nucleotide sequence ID" value="XM_006960811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y547"/>
    <dbReference type="FunCoup" id="I4Y547">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y547"/>
    <dbReference type="GeneID" id="18475810"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70886"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="InParanoid" id="I4Y547"/>
    <dbReference type="OMA" id="NVSCNCI"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="153"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM19089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="498" mass="55853" checksum="E4FF2E8B3BB3C5C8" modified="2012-09-05" version="1">MTCPHIESELEKKDFLRKLTLGVNWGIYTLHATPSKTTTRCKLSQKLLTRPQLCLTCANCFHFDSLLTHSAENHNFSMDVLSGHVFCSGCKDYIYNPRLEKLIKLLHLRQEERATKRKTTNGSIRSSFRPLNDVPKVKLTNGVFSNPIALRPRGFRNLGKTCFLNVVLQAFIANPLLRSYFLSEKHNHILCSKEGCMACEFDKLFMQVHQPDLTPLGPISLLHTLWTAPGASDLAGYAQQDAHEAYISLLNLIHAGCTTSENIHSDECSCIIHQTFQGTLQSELKCGKCNYASVTSDPFLDVSLDVGTPSSSTNGVSKRGSQTMSKNTSNGAPKNGKGSSVPTVESQTLDNCLKRYTHPEHSDWKCTSCSANEASTKQLSFKKLPTVLAFQIKRYEHGLWAQKLDAPVRFPLVLDMRPYVALGDDDEPDEMYLYDLFCVINHLGEMDTGHYTCASRFGEQWFRCEDADVVPTTIKSVLDSQGYMLLYIKRTLVYYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y575</accession>
    <name>I4Y575_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TAF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960844.1">
        <property type="nucleotide sequence ID" value="XM_006960782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y575"/>
    <dbReference type="FunCoup" id="I4Y575">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y575"/>
    <dbReference type="GeneID" id="18474648"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61633"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021711_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y575"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="6">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="464" mass="49809" checksum="059C1154274434DB" modified="2012-09-05" version="1">MEDKPRPEIQAGIYPTEVIRDVAESVGITGLTDTVATGLAGDVEYRITLLIEEASKFMKHSKRTALLPCDIENALKVLNIEPLYSPHPATSIPTYRRVATPAGPVFALEDKEIDFEKALREPLPRLSKGPSYTSHWLAIEGVQPLIPQNPAPTDNGPMHQLAPAQAALNNNNNNGAGVGGTASTTIHPPVKHLLSHELQLYYIRLTSALLSPATNVPEAREAALASLRGDPGLGGLVPYLVRFAGEKVSTNLSNLDIIDAMVGVVHSLIDNQTLFIEPYLHQILPLLLTTLLTSSYPAPPDQKALWLRQKSASLIARLLNDYSNSYPTLSGRVAKTLFKALSGDDQVLGESASTDIGTRFGSVLGLKAIGKNTAVRALIHEKGLKGLSELAESLNDEAKMQMIDVVIEVLAEVLPEAKAVEINSSQIEDTCGSLIASQIPVKKPELTSSIATALQEESGAEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C2</accession>
    <name>I4Y5C2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_30589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960786.1">
        <property type="nucleotide sequence ID" value="XM_006960724.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5C2"/>
    <dbReference type="GeneID" id="18471155"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30589"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004854_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5C2"/>
    <dbReference type="OMA" id="LTAWGMD"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143018" checksum="1F36ADEBC98BDC65" modified="2012-09-05" version="1">MSARSIRSGSPVSTSSSAGGEYISTNLNGISNLARADADLIPKSVIDLNEDRYSDENKHASTLVKPFIHDRSISYVDGVPPEVYLLQNQTGELNLDSSQYNQLLQRAFTAPMSSRLGHLAQPGLSNFIHTSDDASDSHPKALQNQTSQELANLVQLTVQTIIQLSPPHLLDFAKEQYAACGLTFPTPSVSSFLTVSKVLNYLSVFPSSSKSSRLMSPKFNKSWDIGEMLQGIADSLAGLAAERSINIVIAHAGANLQHVSVKGDRASINEGSLSFGLLHILRRILDTALPGSSLEISLHITPEPDDETETKTSRLTCTFEIQHYHPKASAFSLQQQNIPSPFLANLVTRHILSDLVVDLKSRPVFACTPDEPHRRCYDFVLSLLEGDPLPECLLTPEEEASRQPFGQNFALAREPTIRELETLATKDLHNYEAEFYCHPDNIFAKHICGYLSSWRMQVNVHNIDNGDSANDLSSQSQNTKVPLTTERTSENEEMTPSDVSNDNTSFETGLGVNSENHTIGAEDESGKHTDIPNKARFIIIDDDIITFKKTLNSERLKVIRRYHQSLASQTKVLNPQTNRPSLHSRHTNSSQLDQPSSSQINNGGPYFIHFTSLENYKLVIDAILSARVPLDTSSNESFNFDLPNIQVLPKPAGPRRVLTALHTSINKPVVDPHFRPLATTPLSPSVYTGTSGSRSSFYSSFNASRSSLGRTEEDKTPSDQIGHRSPSISSQQLNDNLSPQFHHKNLANDSQSNVSSISRGSQSVTSPMDTTAINYFSHKAAELGDGNKGMLIQSHDGRAAGVFFDPTQSPVEELHSDEKNENVETKGSNTTQASSNPSRVKRNRRHSNANPAVSRHGSVRRSALYKPNIGLKEMIDRAKSNGLVEDERAEDEDSKNANIVSRASTTALHEVAQESAERPDTLNHSQSDPPPAMYADAAPSITSLPKFTLDESEDIPRPPSSDQHGTPTPTQSVKGIPGPDKKKSNSSQTEVSQKSVSTASASTSTSTVKEGSNASVSTFGGNSLDIPKTDSPDVTQEQKENPFDNLVERSPGERPALNTRQRSKSVLKSIKDAAQAARRDVQSKYNESKTNDYPAKSVSSGWMSGSNVTPPVNVLIVEDNPINQTILKKFMTRRNVKYDIALNGEEAVEKWRTGTFHLILMDLALPIMSGVEAARQIRAMEKNQNIGVFPSTPPSELPRQASEPSDDLPHDASIRSFASSIQTNFKFRSPVIIVALTASSATSDRVAALEAGCNDFLTKPVNFQWLERKIIEWGCMQALIDIDGWKSFRMKRFAESEDKTPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F0</accession>
    <name>I4Y5F0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_55709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960764.1">
        <property type="nucleotide sequence ID" value="XM_006960702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F0"/>
    <dbReference type="FunCoup" id="I4Y5F0">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5F0"/>
    <dbReference type="GeneID" id="18472739"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55709"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039675_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5F0"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="324" mass="37088" checksum="DA2EE89558A17AB8" modified="2012-09-05" version="1">MEALKQELARKRKENDSNLKDNPTKYLKKSQLDSLTPEPIQTQPQEDTINKEEEPEAEEETNITDNDTKDFSISNDECIRRLRLKSEPIRLFAESDRERRLRLRALELLASSGNSKGQENDLRKALEGVGQAELEQQSKNASTAVNAKIYDQSEVEITWKMVKVDNDKLYATIYKWMKNMLRLWENTLSQRPDDVRRSKQGQLAAANQVQTANYLKPLFKALKSKTIQMDVLTLLGEIILYAQERKYQNANDAYLRLSIGNSPWPIGVTMVGIHDRSAREKISSGSVAHVLNDEVSRKYIQSVKRVLTFAQSQFPPEDVSQMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G0</accession>
    <name>I4Y5G0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960774.1">
        <property type="nucleotide sequence ID" value="XM_006960712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G0"/>
    <dbReference type="GeneID" id="18474629"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61597"/>
    <dbReference type="HOGENOM" id="CLU_1908309_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5G0"/>
    <dbReference type="OMA" id="IYYEPSV"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14882" checksum="CC0A7D1174EE3BDC" modified="2012-09-05" version="1">MSEAFPSTKTIQEDGLEASLEIYQDRLMVIITEIGRVSSLIQVDISDKEESNELIENIYYEPSIHSNLLNLLGQYSNQEQLVSNTIATLFLKGSKVSPSLPFTSCVVGLGLNVKEEMTRERLIKILALCTKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M7</accession>
    <name>I4Y5M7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960663.1">
        <property type="nucleotide sequence ID" value="XM_006960601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5M7"/>
    <dbReference type="STRING" id="671144.I4Y5M7"/>
    <dbReference type="GeneID" id="18473072"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58821"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017397_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5M7"/>
    <dbReference type="OMA" id="RMQMSAS"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="776" mass="84495" checksum="611965F844A9FF41" modified="2012-09-05" version="1">MASHANRGGKRNNNAFNSANRKQSWRTPKSTEKLQAAIGKPVLISTRQNERLKGTLISTNQEITLKQDNKQFKVQFKDLLDVEELKDNSFKVDTDISKSKRTNERELQPWTPDGLFDDPAIVSSSQDASISWADDYPTNDTFGTSDGAWDQFKANEQMFGLQSNYNEELYTTKLDRSGDNYKEREKNADKLAKEILNQQSNNPHVAEERGQTVALSEEEKYSGVTRGPNAYVPPQARKASQNAPVQPAQQQQPQQQPSQQPAKQSAPQPQQAQQPQAQPPTAPKSHVQMQLPHEKASSKPTDPSLIGDFKAFVSHEKERLQQKKQALVKQEKSSTVADLIKFGQSFKLKTDMPEDIASIVAKNNEKKAREAQEAKDSKADPSTLQTKAEPSKQEKSPSLKQYMNIPKIPPFNPDRVKAVRAERDRHVSQPISASPKSPPNEQKSIASPALSQASTSTAGGSKTLNPKAFSFKPNPNALSFTPGASMSPKPASQSTSQASQSTSSGSSNPFFGNKSIRRGLTGLHVKEDFNPFKHSTVVEAHQVGPHWQFSGKSYKSRFPTNPYYGGNEYNTPEEAIAAQNMVVAQAQAAAQAQAAVMGQGQQYYYRVPFGGQSPIPNGGPMGAPYMGPQFVAPPPGQAAVGFAPQIQPGQGPPPAQMFQAAMAAGLQAPRQPYLPQFSPNMQSRPPMTGPPPPHHPHSHQSTTPTPQQSQSSQAGPPMFAAYPSPSPQMTPLVPYPAPPIAHIRPMGVPQAGSPGPISQTPSSYSPAPSEAQQQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y698</accession>
    <name>I4Y698_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960415.1">
        <property type="nucleotide sequence ID" value="XM_006960353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y698"/>
    <dbReference type="GeneID" id="18474520"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61413"/>
    <dbReference type="HOGENOM" id="CLU_1422452_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y698"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698576" evidence="2">
        <location>
            <begin position="29"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="191" mass="21830" checksum="1A7C0023B7AB1FB5" modified="2012-09-05" version="1">MRAGFRNIKKTLFLQLIVIMTLTSSVYAEGILATKGRENNILQWIKWVLLDADTSNLRAGIVSLYIGTSFIENECNRNEQGKIINEEGCLINLVVGCIFSVYAIYRLGDGFFNHEVTQLMQFEGSNSSKSAMNSSRLPIKSQYRVREVLRKFTLYLSSTWSMEIYCIIILMTEMTVRLFIWKAKTIPAMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6A4</accession>
    <name>I4Y6A4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_70524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960421.1">
        <property type="nucleotide sequence ID" value="XM_006960359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6A4"/>
    <dbReference type="STRING" id="671144.I4Y6A4"/>
    <dbReference type="GeneID" id="18475754"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70524"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544234_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6A4"/>
    <dbReference type="OMA" id="IGEMITP"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF31">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR_REPRESSOR MOT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="468" mass="53070" checksum="CA425EDDFB98D9AE" modified="2012-09-05" version="1">MPEGSDFSCPTCHAKFTRKQHVYRHMRTHTGEKPYECEICNESFSRSDLLNRHQSKCHAGHPLVPKKGQRQNRKANMSSAFDRQIQQIEAQKQKQQQKQENELNTQQDVNLSEPVLDLSSIKPDNDLNAFAQSLGQVYMQQQPPLTPSLLSTQPVNQSQPQVQPQAQPQSQTTNLSNFAAQTAAVWSQFFNNQQPSTLGTTNDNALKQIYEDQLNESQSNYLSTLPTNKPSTPSALPHTPLEFKLPISPQNQFVNKPKSPLYNADMQMLMKDFGVNGDDAQKQELDEHNMQDIWSQYLSIPMTANQQNQSQQQQQQENGKEFAVAAVNKSASDASNLKLNQPPLMKALHKHQQSLSDQYRLPMLSGPPGAARVAGEDLREYEQAVLNRKLPSLTLNPRFARYRRDNSPVNDEVQRRDQSKASVKRDLNTPNVPDDNKRYAFSLPTPLSPQPATDNKPRYNEQVAVRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6E4</accession>
    <name>I4Y6E4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_34001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960459.1">
        <property type="nucleotide sequence ID" value="XM_006960397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6E4"/>
    <dbReference type="GeneID" id="18471789"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34001"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691821_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6E4"/>
    <dbReference type="OMA" id="YAWELYF"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="399" mass="44125" checksum="50130FCE57842600" modified="2012-09-05" version="1" fragment="single">MSNEATTRNHLDDRYNTQLGVRKVIAAQYAFSSSSITLLSVGIFLASFIFAFDQGTNSYMTNAAFNEIGHSRAQLAVLAASSIINATGKPFFGKLLNVVGRPESLSITMLCMSIGYFISAASPTIIGLSVGRCLWQLGNSGFQIALQVVIADVTNLRYRGLFSAIAGSGWQFILFYFAGKIVNKALSPHGVGWRGVFCIEAIFFVPAILPIILILFRAQNKANKDGQINVRETKVPLQEKCYNFCSDIDIVGLYFLLGWLVYIFLPIVLTGQSSMEWDGSTLPLMVIVGVTVIFPSFIYWESHNAVHPILPLRFLLNRTIISTCIINLCDFISFSLSFNTLTQFIYVATDYNDASALYLTSTQNLCLSFFAIAFGLLVSIYQMKWKTPVVIALLVRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H4</accession>
    <name>I4Y6H4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960364.1">
        <property type="nucleotide sequence ID" value="XM_006960302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H4"/>
    <dbReference type="STRING" id="671144.I4Y6H4"/>
    <dbReference type="GeneID" id="18474504"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61391"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006272_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6H4"/>
    <dbReference type="OMA" id="NVHRACQ"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065">
        <property type="entry name" value="OS10G0469600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="947"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="106524" checksum="279F423366CBFE65" modified="2012-09-05" version="1">MIGDDKVLRKVSSKSSINLSKDEIIQVVERVVQQDSKLVDTWDLSKAGIDAIPLEVLDLIQKDTCRLALSYNRLSRLPDRILNLNKLRYLNLRANMFTSFPLVLTKMPQLEILELGRNKIKKLPKDPGTLVNLKVFSISKNKLTKIPTYIHRFTNLRIIKIDANPIEWPPSSAVESFNQQAQSAVSMKNDSDKDKLDVEMEAWVRALRDWLKEHADKQALKGAYTTDEDSDYHRRRQSTNSFSGDSNIHSPPLPKEKDRVLGGNSGFKFPMSKGTTPPTPGLVSPSTTHTSPDSLSQPSTTFNSNSRNHYFSPTLDIYNSDYASNHGRNASSSAILPKRSNPNQEGLKVKKSLPNMRYGTNRILTDPTPLSNNTLTTNDSLTYAVERKESVDLPPIPNLPKTSNGHIISNLGFQAPSSTSETSSQSQQSQNDEVMTPITRNIEHLKRLAIKSSDFSSTFKHRHTPTPPSPLSISNTDIVVDAANSLLFALSQTHSAINQLISLTSDNFALFIIPLLNSAGKGLEPLFDALDSRKLSTRSEAIMEAVKISSAAFSPLISELRARIANKFVNDVQYVHPVVLRSVILTLYGSMSEIANVWKVISKHLPTKQENQLQLQQLQSKPRGSVDKSTKRMYRQGVSLTQADFDYVNMNKSGKSDNTDNLPYLSKAVEDPRTPTSRSPEPQMDTLRVTPQTPTSTIQDDAEDLLELIENCIVVGTNFWPVLDEDVDNSYSHDFSPGGSAVDPVMVELRDKNNQAKELTDKLSKSLNVVKQASNQDGVIGLKAADQESVRELFENASTFNKMVIWMASLVKGLGEMKRLPLKTRRRMQQIMDLVSELTVQVHVSSYRPLAPSPHSAALNMATSNNSSRSESPKLMKSSKKAKEKGLGFPTPVLSRSQSSQPGMPVKRPTQPRSATNFGAGLTRVFSPTSYSTSNNNEGYSKKRTGSLSGYSASSDSTNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I1</accession>
    <name>I4Y6I1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960371.1">
        <property type="nucleotide sequence ID" value="XM_006960309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I1"/>
    <dbReference type="FunCoup" id="I4Y6I1">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6I1"/>
    <dbReference type="GeneID" id="18474508"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61395"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6I1"/>
    <dbReference type="OMA" id="RGGFTQW"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="15046" checksum="8BEE44FE66EDC1E1" modified="2012-09-05" version="1">MSFGLPYEFVNDKEIVDLIGKPSELLVVDVRDEDFLGGNIKGAKNVPSRSFLDGVHNLVKESEEIPKVVFHCALSQVRGPKSARIYAETRKNLLPDAKPQEIYVLRGGFTQFQAKYGDQSALVENYRKELWEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6N7</accession>
    <name>I4Y6N7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960292.1">
        <property type="nucleotide sequence ID" value="XM_006960230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6N7"/>
    <dbReference type="STRING" id="671144.I4Y6N7"/>
    <dbReference type="GeneID" id="18474483"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61364"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y6N7"/>
    <dbReference type="OMA" id="TLGWGWR"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="147" mass="16608" checksum="8CD9E95C26166DB2" modified="2012-09-05" version="1">MQWQRPFTSSFREFRPKFHGDIVRPKKGTGIKVHFVDSKKNPIKTIETNEGDDLLHLAHEWDVDLEGACEASCACSTCHVILEPEVFDQLEEPSDDENDMLDLAFGLTDTSRLGCQVHVQKTMDGMVVQLPSATRNMFVDGAKPHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T9</accession>
    <name>I4Y6T9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960342.1">
        <property type="nucleotide sequence ID" value="XM_006960280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T9"/>
    <dbReference type="GeneID" id="18474498"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61383"/>
    <dbReference type="HOGENOM" id="CLU_2225259_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="12583" checksum="DAE23C7168CABCA0" modified="2012-09-05" version="1">MPEELDIYNFSIALNPEIQDHVLWKEPKTLIDAYQYACNFEQTIISDRHLQRRFARKRSNMQCYGYEQIGHLIRKCHHSEGFLVEVTKSSWGKREHSGTKMITIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y6</accession>
    <name>I4Y6Y6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_70396</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960236.1">
        <property type="nucleotide sequence ID" value="XM_006960174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y6"/>
    <dbReference type="STRING" id="671144.I4Y6Y6"/>
    <dbReference type="GeneID" id="18475729"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70396"/>
    <dbReference type="eggNOG" id="ENOG502T32I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y6Y6"/>
    <dbReference type="OMA" id="HIGVHNA"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697577" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="226" mass="23260" checksum="117623FFF9563208" modified="2012-09-05" version="1">MIGKLTVLAAALATANAHAFLETVTVDGSSYSKTDSDTPIWAWSPDNGPAATVEDISNPNIACHANAEPATSAASVAAGGTVGFGWGKGLHKWGPFLTYAAKCDLGCDPNSAEFYKIGEINIDESGEWPVPKYVDAGQDVPVTLPSSMEDGTYLLRTENINLGAIPAEIYAGCVSVKVTGGGSGLSGETVKFPGAYTGEEPGLTKQPYDVTGPSDYSDLPGPAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B6</accession>
    <name>I4Y7B6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960001.1">
        <property type="nucleotide sequence ID" value="XM_006959939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B6"/>
    <dbReference type="FunCoup" id="I4Y7B6">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7B6"/>
    <dbReference type="GeneID" id="18471728"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33686"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_13_2_1"/>
    <dbReference type="InParanoid" id="I4Y7B6"/>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="172"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="431"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="711" mass="80169" checksum="3CE43EBE4488895A" modified="2012-09-05" version="1">MPPYALNKRKRGQDLSWKKVDHKFADAEGDGWMGLEEIDGVDVDFEEGHSGERIVKLRSVQNVVDVPFEEDEEPDDAQDTQPEKKKSRKELKKAEKRDAAKKKRASAKQAKREVDEAKKPKEPAPEPEFDVTKLPEWSADNLSIAKDLPSALLRSLHENSIVTPTPIQKESLKASMIRKDVIGIAETGSGKTLAYGLPILSRIVEGEIPEESLAALVLCPTRELALQVAGELKKFAPRVQDITRRVNVATVVGGMSIQKQKRQLQYANIVVATPGRLWEVLLDDGTLAKRAIRSQFLVIDEADRMIEAGHFEEMDKILRMTQRTSKSSTAAFQDEFESTEIGLPEEVPATDDMQTMVFSATLSKDLQQNLKRKRKAGSGKKKQEVKSSLDDLLMRLDFRDLEPSIIDLSPVNKVVSTLEEARVDCLSTDKDLYLYYFLLRYPGKTLVFVSSIDAIRRMIPLLETLKQHVFPLHSGLQQRQRLRNFDRFKSLPNAVMIATDVAARGLDVPSVDHVIHYQVPRTADAYIHRSGRTARAQRSGLAVMFVCPEERRMSNDLLKQLNRDNGLSHLQIQFNILDQLKARINLATKIEATRHKTTKAKFDSNWEKEAADALGVDLDSDHEETQYNLRGQKKKRVGVANLTDKEENALEKQKAELKNLLSQPLMIRGVSSKYLTTNQSTLANEMVNNDNHKNILGVSKSTALNDLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H3</accession>
    <name>I4Y7H3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_21634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960056.1">
        <property type="nucleotide sequence ID" value="XM_006959994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7H3"/>
    <dbReference type="FunCoup" id="I4Y7H3">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7H3"/>
    <dbReference type="GeneID" id="18470894"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21634"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7H3"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="24995" checksum="506EE34F475D463E" modified="2012-09-05" version="1">MADQTHKIYYLGAFDSAEKPAINIQQCDDLGSFSFYQRSSVREFLVFMAKTVAERTENGQRQSVQENNYTAHVYRQGNYTAVAIVTEQYPVRPAYKVLDAVPGAVRTTATYSEWVDGIRKGNNTTQSPVVLPELNTLIMKYQDPKQADTIMRVQQELDETKVVMHKTIESVLERGEKLDNLVERSNALSAQSKMFYKTAKKQNSCEFYNTMVLCCLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7J3</accession>
    <name>I4Y7J3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960074.1">
        <property type="nucleotide sequence ID" value="XM_006960012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7J3"/>
    <dbReference type="GeneID" id="18471737"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33737"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y7J3"/>
    <dbReference type="OMA" id="FKQWGFN"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="470" mass="53079" checksum="B96908F6E2C5AD1E" modified="2012-09-05" version="1">MNFNTSVYPNAVVSISQTWDVSEQAARVGQMIFLVLYAFGCELWAPWSEEYGRWPILQLSLFLVNIWSLMQSLAPNYATMIVGRALAGLSSAGGSVTLGLCADLWSADTQQYGVAYVVWSSVTGTTVGPIVGGFLQSFAPSWRWIFWIQLIFGGFTQVLHLLFVPETRSSILLDREAKRRRQEAAKAGKTVPNIWGPNEVKAQRITMKDITITFIRPFEFFLKEPIVLFCSLLSGFSDMLIFIFLESYNPVFEQWNFKSYQVGLAFIPVWIGYFIGWGSFLPFIRRDIKRRKIDPYSVTPESRLYWLLYTAPLEAIGLFGFAWTSLPPEEYETHWIAPMIFAALIGIANYCIYMATIDYMVAAYGPYSSSATGGNGFARDLLAGISAMFSTPFYSHFKGRNKLTYPSTILACIAAVLVAPIFMLYFYGPTVRRKSRFAQSLNQENESTKIRKQVRDEKALGSAKHIEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7K4</accession>
    <name>I4Y7K4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin/40s ribosomal protein S27a fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960084.1">
        <property type="nucleotide sequence ID" value="XM_006960022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7K4"/>
    <dbReference type="FunCoup" id="I4Y7K4">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7K4"/>
    <dbReference type="GeneID" id="18471740"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33754"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7K4"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="158" mass="18135" checksum="C3A27150FE26CF0B" modified="2012-09-05" version="1">MQVFVKTLTGKTITLEVESQDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKRRKVKMSILKYYKVESDGKVKRLRRECPAPECGAGVFMAWHHDRQYCGKCGLTYTFEPGTKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Z9</accession>
    <name>I4Y7Z9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959812.1">
        <property type="nucleotide sequence ID" value="XM_006959750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Z9"/>
    <dbReference type="STRING" id="671144.I4Y7Z9"/>
    <dbReference type="GeneID" id="18475045"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65674"/>
    <dbReference type="eggNOG" id="ENOG502SB46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215603_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Z9"/>
    <dbReference type="OMA" id="GNMARSK"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="25080" checksum="82491660B7163FFC" modified="2012-09-05" version="1">MAHLRRPSIDSSVSHESFAARIGGKFRDAITPNISHDDQDDSSDKRGRSFFSRGRDNRSESRGRDPIVSTGRGGAGNLRASSKTRAAYESDAQDERRGRSSHATPPKAVHAGRGGVGNVRSPSRDPKDIRNQQAEHQLEAKLQREAQEKAERDGVIPTGRGGAGNIRHNEHSQSRSRSRSRTRDLLQRATSRDRSSSRDTQAIYNNSTNNSVAHDVHDPDTSLAAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y818</accession>
    <name>I4Y818_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959831.1">
        <property type="nucleotide sequence ID" value="XM_006959769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y818"/>
    <dbReference type="FunCoup" id="I4Y818">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y818"/>
    <dbReference type="GeneID" id="18474348"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61127"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007738_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y818"/>
    <dbReference type="OMA" id="CLRGCFL"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="215"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="555" mass="63489" checksum="4B2942686C0C1FC3" modified="2012-09-05" version="1">MGEGMKKAIAQLNAETKENALESEGIVKGGEVIKVVWEKLMKSSGDPVAHEVYNRLLFHASQPYAEMLLSWTTSGDLDDPYDELLVREAKSISKKGLDMDYTDEYWEKRYTLRDGSSVDKPFKPDTAFNSDGNLKRLAGGACVPPFLEAWKFKILFAGKYLNVIRECGIEVTKTRNFAELDKMSINSAPFYKQVEDAYTHANRALLKLLLEDEGLVSRLRSLKHYFFLAESDFFVHFLDQSYNELRKPAKSANLVKLQSLLDLTLRNPASPSFNDPYKEDVKITMNKEPLYQWLLTVVNVSGALGQEENFNQRKGAEEKPIRAIEGMSFDYTVNFPLSLVISRKTILRYQLIFRFLLHLKYTENALVGMWGEHAQDCWRRNLNYKPFDMWRTRVCVLRARMLEFVRQVTGYVCEEVLHIKSLELEEKIGRVQTVDALLKDHVDFLDGCVKECMLSNARLIERLQNIMKTIGTFTLYSVQLTKTAVEAMDAIIGARKSGMEPSETLVPLAKIWNELNKFEHAFNKQSKIMRDSLAFYASSENPSLLALLARLVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y823</accession>
    <name>I4Y823_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Supernatant protein factor, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959836.1">
        <property type="nucleotide sequence ID" value="XM_006959774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y823"/>
    <dbReference type="FunCoup" id="I4Y823">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y823"/>
    <dbReference type="GeneID" id="18474350"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61130"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y823"/>
    <dbReference type="OMA" id="MQVRDRN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697695" evidence="9">
        <location>
            <begin position="18"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="192" mass="21873" checksum="5B7EB576EFA91868" modified="2012-09-05" version="1">MQQLLYAILALAVTIEAYIVTIPARSKDCYFEDLHKNDEMTVTYQVSSGGNLDIDFALSDPSGPLYTNNGKDTGTYSFIADKDGRYTYCFSNAMSYNTDKTLSFNVHGILYVPDEGHTLPIEHEIRVLADNIKAVQDEQEYLKARERSHRNTAESTNSRVKWWSLAQSGLLIVTCAWQVYYLKAFFEVKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y830</accession>
    <name>I4Y830_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959843.1">
        <property type="nucleotide sequence ID" value="XM_006959781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y830"/>
    <dbReference type="STRING" id="671144.I4Y830"/>
    <dbReference type="GeneID" id="18474352"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61133"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545357_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y830"/>
    <dbReference type="OMA" id="ARNEAMQ"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="193"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="45123" checksum="8E00442FB9458037" modified="2012-09-05" version="1">MVENLNRDMQQLKTRVKYGEEAHVQMQSIQNKLNDITNNQLSEVQVSKIVEKLLPHRLLVRKSPTGEAIIDEAFWKALRSVFETQNTISNPNWDEFIRDNSDKLKDWMYTDGGLDEQVVNRIEFMNIVDDRVKSFINSASGKKSGLNSWFRGGTSTPSSDELQSIVNDIVQTSLERYSADTIGKTDYALFTAGARVLPANTSPTYSITPVSFTRKVLGKLLGSGTRAYGRPPVTALHPDINVGMCWSFHGSAGDIAVKLARSAIPISGYTIDHASPLLVQDRSSAPQTFELWGLSEDQAQIEKIREINEEVIEDVSGEFPVNEKAPTTNAALLGVDRYDLNGHHIQTFGVRDIVRELDFRPDAVILRITDNHGNKHHTCLYRLRVHSSTDDRRSVLVENDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y836</accession>
    <name>I4Y836_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_55255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959849.1">
        <property type="nucleotide sequence ID" value="XM_006959787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y836"/>
    <dbReference type="FunCoup" id="I4Y836">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y836"/>
    <dbReference type="GeneID" id="18472722"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55255"/>
    <dbReference type="eggNOG" id="KOG4772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028449_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y836"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="455" mass="52124" checksum="3996E6EE0BEFA211" modified="2012-09-05" version="1">MDQDEYKIIKNNSDESDDNDSAEDEVPDYRQLASFTNRKSKETYIPRRGEKEFEPTGLKIQQKALDESREAMFSAIDGVRQSSNKNISIGLWSNSQSRASIIIQRGTHFSSIGHPVRNTPAKFEGNAQKVASETRLELLPEEALYMVERGSLMCYEYEWSDRNDKMLKVSTNDSEVDTRFSNLPPFSAQRAFDCCIGKDGLTLEKYTIYAQLKRLGYIVKRAEQTETNIVRRGSILGNLWKSLQGVFKALLSPFAALVRLFSLRFGSLLRSRSCLLTPHQDYDSIFKSLRLIPSGYSKAHESSAKLDQDEQHEFDVTWHVWRPATKFKKSSPPPPDFRIVVVDAQKSSLPSMHQFAHMFSQQPYSAPPMTRKQKLQREKQSKEGKGEDTPQTTWLWRWWNRKQLAADEAKRNKDPAVMFPALKYGKRAVVLAIVDSGTTSWIQFGEGQFGDFPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y843</accession>
    <name>I4Y843_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_40401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959856.1">
        <property type="nucleotide sequence ID" value="XM_006959794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y843"/>
    <dbReference type="FunCoup" id="I4Y843">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y843"/>
    <dbReference type="GeneID" id="18472171"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40401"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280210_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y843"/>
    <dbReference type="OMA" id="GQCAFEI"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="957" mass="108250" checksum="F4017BEDD52515BA" modified="2012-09-05" version="1">MSEVENLLQNAVSQNILQLQQATDELDRKLRQTDFLDLLHAYAISDADSSLRLSAIIVVKNNLIGFWRNIKSLQLSDNARFNIRKRSIEFFDVNDDKISSLNSIILSKIARIDYPRYWSTLIEDILARLDVDLALQDATHLTRLRRATYTLHLIVKEISAIRIANKAFPGLYATLFNYMLNLYQLAFTNLNRNLDWIHIAIYSHKTLSRLCLHNFNRSSDEELANSASFTQLTISHLPHVLEYKSNSDITILFKLVNSFTKHLKLLQSTNQRKFSSIPNVELIIPLLFSQITSSPYTPSPPKYIIHILLILKLTLADWTPNNVNKDNPNAVISDEYAVQIVHFLIANYIPLTSQDLERWDSAPEDWVYEDDLDQWEIDPRPCAENLIVGTLIKRREAVGAHICTMLQEASSLEATSTNLIMKESVYRIVGKCAEYLYDQIGFEEWLDKSLIPEVQISGSDQRILRRRIAVVLGRFSGESLSPEAFTKIYTILLHCLRPTEVANDVAVQVTAAITLSGVVDTWEFNPTLFEPFLNDIMPELIRILSACEMVEVKLRVLKSVTCIIDQVGDKAIHYGPRLLELVPGLWDDSEGDWHFRGGILSMLSRLVAALQEGSNRALGIVVPLIKSALDPSQGKPFIDVDGIELWQTTLKHTPGLDESLVSLLPLALETFKNDLDLANDVAPVIESYIYLSPELVLSQFSPALFSAINETLDYAQDRLRDQIIDILNLVTIAGSPSSWANALNDTGLFRDLFVKLIENKESPVYLSKFILFFSRICIVDTEMFVQLVRMSAASLNVPEEVALGYLLDRWWDKWDNLVDNYERKLSASGLARLVASGHQTVLERLPGEISNVFVDVLAEIKERRMESEEGGNPVVNITPNPMLNEVGDEGTAEKTRKLAIYSNDPLSSFTLPQFISHSLAHAQQTFSGGPDAFNERYFMQADQAVTTQLVKYMNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y874</accession>
    <name>I4Y874_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_21228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959886.1">
        <property type="nucleotide sequence ID" value="XM_006959824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y874"/>
    <dbReference type="STRING" id="671144.I4Y874"/>
    <dbReference type="GeneID" id="18470879"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21228"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_6_2_1"/>
    <dbReference type="InParanoid" id="I4Y874"/>
    <dbReference type="OMA" id="PWTKLDH"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="15"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="422" mass="44236" checksum="9CB0E838C06B7298" modified="2012-09-05" version="1">MSASGFNAQATNGKQLIGAYYPDWQTNRLPVNQIDWTNIDYVSYAFGLLSPSTYEITLSAGSDSTLTSLVEAAHAQSPSKKVELSIGGWTGSEPFSEAVSTDANREKLATAIVNAQKKWNLDGIDLDWEYPGLPGAGNPHTGSDSANYLKFLKVLKPQLPSGVTLSAATAVYPFAGPDGKPLADVSGFGEVFDHILIMNYDVFNAAPAPGPNAALKDTCGSSKPGANAEDSIKAWNEAGMPLEKIYLGVPAYGYLHESSAKALVARQTPTVPGADDTNNGQPTTPNNDQPATPTNGQPAAPTDGQPATPTNGASPVTIKNADGTTAKGQVDFDAIVDSGALKRVSATQFDAAGGWTRKWDECSSTPFLYSGSQVLSYDDPESFKLKAQLAKDMGIGGMGGWTLIGDTNQGDLYSALREGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y885</accession>
    <name>I4Y885_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_65535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959665.1">
        <property type="nucleotide sequence ID" value="XM_006959603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y885"/>
    <dbReference type="FunCoup" id="I4Y885">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y885"/>
    <dbReference type="GeneID" id="18475031"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65535"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="I4Y885"/>
    <dbReference type="OMA" id="CEVDWWS"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="572" mass="64805" checksum="68955C2379CC2D56" modified="2012-09-05" version="1">MATKSPNDNFLNDYESIEVIGQGSFGKIRKVRRKRDGMVFARKELDFDKMSDRDRKQIVAEVNILRELDHTNIVAYHERYVDREGGMLYILMEFCGGGDLQTIIKSCKRSNTLLPEDTIWSYISQLAGALDHCHRRGSTAAGPQKLERRPSQHDIAAAHQQILHRDLKPENVFLDNDGNLKLGDFGLSKATQIGEFAKTYVGTPYYMSPELMKDMPYDHKSDIWSLGCVVYELACLNPPFYEAKTHGQLQEKILQGRIPRLSRFYSPMLDDMIRRMLSPNPRDRPSASQILEHDKIKLQMRTVELNKMAASIASQRVRLSERLSELQAREKKVCEREQQISVVETQIDAYIKSQVEKNVRFELERIMQEGGSEYKIMTDSTNIEQRDREIPNRSMKEYVSFDSLIILTVHSSATPSETLAEMSICTPPQARRMSSKQGLNAHNATQAKLLALAREEDEAENRSEHVTSKPPPLQRAETAPVSTTSSTNSIPQWTNLPPPPPTPSYANVTEDDLPSPFLRKTDNKQKLNQSSNPRQGLLAQAAAQRTTTNKSTTVSKRPSMVSVKSSKPVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8G5</accession>
    <name>I4Y8G5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_70015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959745.1">
        <property type="nucleotide sequence ID" value="XM_006959683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8G5"/>
    <dbReference type="STRING" id="671144.I4Y8G5"/>
    <dbReference type="GeneID" id="18475676"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70015"/>
    <dbReference type="eggNOG" id="ENOG502RDU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056802_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y8G5"/>
    <dbReference type="OMA" id="ITLSMRW"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697702" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="204" mass="22640" checksum="03ECF598FC23AA8F" modified="2012-09-05" version="1">MYTHRIVISLISYLITFVLAIENKAEAARLARHLVESVRGIGTISTVFPEGHGLQGHPFSLEAYYAPCYRNGSLTVLMMPISQSFNNILHNEDHNATISVMPLDGTARASNYRVGLIGHISEIDKRSSNGMGDEGSRLRECYLSTHPDSAIWVPPHGVPHNSYFARFDIDHVWYTGGFGNSHYIGYIPESLYSVSTAESNVIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L4</accession>
    <name>I4Y8L4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_65438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959563.1">
        <property type="nucleotide sequence ID" value="XM_006959501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L4"/>
    <dbReference type="STRING" id="671144.I4Y8L4"/>
    <dbReference type="GeneID" id="18475022"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65438"/>
    <dbReference type="eggNOG" id="ENOG502SA0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769880_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L4"/>
    <dbReference type="OMA" id="RFILITW"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098974">
        <property type="term" value="P:postsynaptic actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="292"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44429" checksum="12A0F6D2A7E24413" modified="2012-09-05" version="1">MSVSLVDPNIRHAHNDQIDQGNGSWIELGYPQDSKDQLILIGKGANGLEGLSDNLPEDQVVFAILLENSSLVQLLWCPDAISGVKKARAMVHARAVASQFDISSTISASTKQDLSVSQLTAQSKVEKKEDSEKHTNGALPSAEESATTVQNLDDDDDSDDDTDSIVNGYQDVNEPDQQEQQRQLEIAKQKALQEEEQRVEIERKRRLEHEQRLLQEAEQKRRLEAEQQKRRELEEKRRKEIEERRKAEQEAKLRLEMEEKRRREAEEKRKQDIIRQKSLEQDRLNKLISSGQVAINGKLSALTKSGTWRRRYFELSSKALAIYKEDLSSKTPIEAIPLSKTTQIVDSYDELLIKHSIRLTSQSDELFIYLDNQEAKSKLMSALQSAIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y919</accession>
    <name>I4Y919_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959487.1">
        <property type="nucleotide sequence ID" value="XM_006959425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y919"/>
    <dbReference type="STRING" id="671144.I4Y919"/>
    <dbReference type="GeneID" id="18472990"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58150"/>
    <dbReference type="eggNOG" id="KOG3050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y919"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="263" mass="30196" checksum="98E03A4B8EBE093C" modified="2012-09-05" version="1">MTEVSVHPLVILNVSDQINRSKCINSKNIVGIIIGNQLGRSVDIINSFELRLLDDGSIDDEYLTGRLELYNQVFPQFELLGFYTNIPESEHLQEQLFKYRESPLMLYYDESITDSLPFEIYELIKSYEKIFTNNLNLTIKSSEVEMISINHSNKYTNNQLKDSIDGDFNSISLLHSRLSVIVNYLNNLGDSQPDPEINAMLNSLYHLLNTDSHQYKDEFNTEFNDTQLTTLLSSLTTSTNSLNSLLNKFQVINNSFDLLAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y955</accession>
    <name>I4Y955_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_20618</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959523.1">
        <property type="nucleotide sequence ID" value="XM_006959461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y955"/>
    <dbReference type="FunCoup" id="I4Y955">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y955"/>
    <dbReference type="GeneID" id="18470845"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20618"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y955"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM20497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="255" mass="29250" checksum="97913ED39A1DB634" modified="2012-09-05" version="1">MRSFSTSTRRALATPVGAKPPHMKKFQIYRWNPDKPAEKPRMQTYDVDLNACGPMVLDALLKIKNEADPTLTFRRSCREGICGSCAMNIEGQNTLACLCRIDRNENKASKIYPLPHMYIVKDLVPDMTQFYKQYKSIEPYLQSDNVPDGVEHRQSPEERKKLDGMYECILCACCSTSCPSYWWNQDEYLGPAVLMQAYRWIADSRDSKAAERKEKLENTFSLYRCHTIFNCTRTCPKGLNPAKAIAEMKKEMATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9D4</accession>
    <name>I4Y9D4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trs120-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_69729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959366.1">
        <property type="nucleotide sequence ID" value="XM_006959304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9D4"/>
    <dbReference type="FunCoup" id="I4Y9D4">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9D4"/>
    <dbReference type="GeneID" id="18475630"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69729"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265484_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9D4"/>
    <dbReference type="OMA" id="EHSRDRM"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="303"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="604"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="965"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1250" mass="140907" checksum="E821EB4028035603" modified="2012-09-05" version="1">MEDSERFSQSACLNILVIPIKPARKSVYKSSFQSLSSFKQIKGSEVPGFSTFHPPPLSPTSHSIHINYHSNPNNIINDPQIAFSDQFHALIGIVDCPSHPTLEAANEAFNETVECLPQHIKPHIKRCWAFQPRDSDRTVANPSSQLVLVEDSAFYLNTLIADIVGSVLSWFADTAGERRRNDGRQSKLYGDLFLMSGRLKDSLTSYNDGLSQMRAPHDSFHQASAIESQAIAQVLLYWQKTDDVPSHHLIETPWSGICDKFNNALAVYTRLLNTSINKALSTSSTTNLTNLPSQNHDLIAIRAFVRATLRLSQFLLTVWACEGLNDNSLKALVEGVTPSFLATQPDRDSIIEHADKMPHLARSQISTIAQQAHGTHLFHLNKVEQLRVILTLIHLHDSIGFARKAAYFRQEVVVICADLVEASRNKSLIQSSDSKLIVNQLNDNNELLVKILDNICDVYGIDTQSTYLYVNGEESEATENVQQEVENNFKWISVQRDFLRDAMTVVQHLGDLNAVIKYAVILLKVYHASLPAAEQVRLVQIMLAALEALRRRSTTSVELAFWSPDLLLSLEVIPCTDETLPFATNSQQTVLQKLANTPTRRATRIAKSIAVQDEYVEVSATVHNPYKFTLELQAVELITSGVTFESEKLDVYLAPNSYQTLRLKGVVKSRGQLIVLGCRMQMNGTIKRDIILPLSTADEEKRKSKVRSERLEKRSKVKSTGLSSIPSLQRQSMSSRASTVTSMNDTRRATLTSISSGVKAPQYIEVAVVASLPTLIVAGTNLSHHALMLYSGECTTLRLTVENVSDVDVDFINLKFRDNSTDSLLEVIEEQQSKLIDTYDMEYTIAHEPVFKPCVDLSNVTIPARKKATLEIECYGRMGCNQGSIFIEYGSKKINENEQTYARQLTYPLLLTVQQTLEVQQFTALPLERSGMSESREYFGLWPTSPSMMSQPMSPTNQTQMSAPQSPLIEQSQLLQNLDKDANEFLFVVDIRNSFGTPFEVVLERTRDGDNYIVEFGVCRLVQPGLTARLVLPMKRTKLTEEIATAGIPSICERQFIISQASLTPQKERVMRELFWYSQEIYKKVRLYWREPVSTTDRPRVGSLNLYLRKHKLSKRMLNVVKLDALDVELINPTWERLELGREAQLQLKIANRTERTLKLNYQFEVSLDDCLIIKGPKSTHIGPLKPDEEVVKKVNILPISKSHLELRLVVHEEYQDSIIDTTKDWDLKVRNAVGRLEAVNSKPCIIDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F5</accession>
    <name>I4Y9F5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959386.1">
        <property type="nucleotide sequence ID" value="XM_006959324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F5"/>
    <dbReference type="STRING" id="671144.I4Y9F5"/>
    <dbReference type="GeneID" id="18474222"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60879"/>
    <dbReference type="eggNOG" id="ENOG502QQ2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588216_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9F5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52993" checksum="2565240FB68D6AA4" modified="2012-09-05" version="1">MSDEKSQFDKILETNPEFLNWAKKEAMFHPPNQSESVSKFVERRLSERGWPNDVEKILLLIRNESNVTQEQVHNAGNANKGIVNHNEMSKEDEESYAIKAKIQNSITQLPNDPVQISKTIISCINNAEFEADGEIRVLALEATKKAKVDEQTENKYINVWSNDKRAIELLSAWFKDACSTRISELKEWRSTHLPLLLFMIKVIFDNEILIKYNFLELVKRLCASNDPNVSNAAKKLQNKWTHQIEPSMQPAKMTGKRSSSEINNEVSKKAKIENKPNSSLFSATAKPSLSKLPSFKKAPKVQEIPMNQAPTPTNVDVKIPPADTVKPAPKAPVSAPNKQNPFADSLAMMSQEQQKKKPTPAPQTSKPQPPTSQREQEKRQVEPSKKKKQVRWVPERELVSVRYIESRAEQGDYHQPYGDARKLEMDEGAMLRKHVTTEDEDKPQEWEGTHKGVKRTGMRTQNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F7</accession>
    <name>I4Y9F7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959388.1">
        <property type="nucleotide sequence ID" value="XM_006959326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F7"/>
    <dbReference type="FunCoup" id="I4Y9F7">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9F7"/>
    <dbReference type="GeneID" id="18474223"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60880"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y9F7"/>
    <dbReference type="OMA" id="EWEIART"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="137" mass="14586" checksum="85392C13F553D2F2" modified="2012-09-05" version="1">MLGLKSTMNIIDNSGALVAEVINVLKVKSGSGIGTVGDECVVVIKSAKPIPANLNISANSPAAANKIRKGDIRRAVIVRTKQQIRRPDGRFVRFDDNAGVLINPKKELLGSRISGVIAHEVRQKGWGKIASVAPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I9</accession>
    <name>I4Y9I9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_69763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006959353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I9"/>
    <dbReference type="STRING" id="671144.I4Y9I9"/>
    <dbReference type="GeneID" id="18475639"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69763"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669401_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9I9"/>
    <dbReference type="OMA" id="QVAHENE"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="411" mass="45520" checksum="B88101B731D13BCD" modified="2012-09-05" version="1">MSSPDSPYNPSTSNQQYDRHSSPGSADEDKKPANRRKSSKKKSHVCRICQKTFTTSGHLSRHQRTHTGERAFACPWPGCLTRCSRQDNLQQHYRTHLSPRSRKADLSSAKAMRAGIKSVTDVPKELLSKGGRTKGSFIGRKVSAKTEQNMDDRDTDESPTIPFNYLSNPQLPIPSTSSGILPAIDSRRTTTSTKIHPVHLTTRPSPPFAMSPSDNYPVLNPISHLMAPSPESRTAFSPQSISPTTSPMEQTKSTQLQNYSIESSEGNSNAYEVKLKPKVNTATPIPVIPPIYRSASVNQIQTPAYATSEDRFIGQSTSLPGLNLELNNTPSSSSYVVPPARMYTLPTNIAQSTILRPTTAINYAAPPAESFDYTAYQQQPVNESQNEFYQLTAPEESTSLDFNQQWNTQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M6</accession>
    <name>I4Y9M6_WALMC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959202.1">
        <property type="nucleotide sequence ID" value="XM_006959140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M6"/>
    <dbReference type="GeneID" id="18474164"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60790"/>
    <dbReference type="HOGENOM" id="CLU_1455462_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9M6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="186" mass="20740" checksum="A573525593539DF5" modified="2012-09-05" version="1">MNYSPCESLGTCYEDMKLLSSYNRTSETRITTRSVSRQQWCSMGNTAFVNQFASFSYTTVGAFCALGASMGNPIPCAFSLVFGFATFMMQQEAQRISANGAEVVYPNSQGQFNDIETMTKRNVYTDPSGNVYDLIWYNPDKRDSLSYTRGNILLQTIGYLQSDGSGQLILYTTSLVTHLMRITSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9S1</accession>
    <name>I4Y9S1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959246.1">
        <property type="nucleotide sequence ID" value="XM_006959184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9S1"/>
    <dbReference type="GeneID" id="18474179"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60811"/>
    <dbReference type="eggNOG" id="ENOG502SAY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1571825_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9S1"/>
    <dbReference type="OMA" id="WIKPNIR"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="161" mass="18223" checksum="B3F99B0C6C6B1EAC" modified="2012-09-05" version="1">MGNAASKAPRRLSKIQTKEIPRASESLNRMKAPPKEEILKDGQDPDFSANLSKIDPVKIHKMQTNFKPSDKMMDILKGRKIENDIENAAMTRNRLSAQSLLSYLEERKGSSDVTQLNKEFDVENQTMEAISEYLAAPRLGTPFTVKVDNERGEIERVEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Y2</accession>
    <name>I4Y9Y2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-1-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959299.1">
        <property type="nucleotide sequence ID" value="XM_006959237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Y2"/>
    <dbReference type="STRING" id="671144.I4Y9Y2"/>
    <dbReference type="GeneID" id="18474199"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60840"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="InParanoid" id="I4Y9Y2"/>
    <dbReference type="OMA" id="HGRQGYA"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="236" mass="25605" checksum="AA30272FA0F3BBA6" modified="2012-09-05" version="1">MKTTFTVKGVLSDMDGTLIESTPAVEATWAQFAQDYPFISLEDVLKHSHGVRTHENMIRFCKLENPDTIASEAKRFEETILACAKKRQEQGLNGLVILPGVNELLDQLNDNHNNWTIVTSATKVYASAALSISQIKQPESFITSENVVRGKPDPSPFLEGAKVIKQSATDCLVLEDAPSGITAGKAAGAVVIAVLTSYPIDTIKASGPDFIVKDLSSVSAKWTNDHYEITVDAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA09</accession>
    <name>I4YA09_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959066.1">
        <property type="nucleotide sequence ID" value="XM_006959004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA09"/>
    <dbReference type="STRING" id="671144.I4YA09"/>
    <dbReference type="GeneID" id="18474112"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60708"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002477_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA09"/>
    <dbReference type="OMA" id="MCFEMHG"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="186"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="490"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="575"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="960"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1219" mass="131499" checksum="0F841C23165064F7" modified="2012-09-05" version="1">MDLYTLSISLPLPDLPNKSFIFPSDDFRKSADLATIAAALTQTHSCLVKYTVTDSQSLWHLSGSIQNVLSARGSLIRDLPLNYTETLKIPKSDILVHDLNSASGGQGGAQSSASTQLSCLNPLIRDKLVELNSTMNVNFSLLELPPSNFQNGLQLQSLVQLSILGGQESVEHAKIQILVTIDQHLGLHADKVDIDFKLHPIIASKKRSVIRTIEEETETNIYLPPPLAGVLGNSSPRAGSLPDHRNLIYITGDFFGVQRAKDMLVQVAVQKVNSKSVLSRDAALLPRKLDSLVVEKADEIRTIMADNGTFIKFPIIGSQASIIQIFGDNRVSIERTIRSIMQLACYYYVASVWLLPVTFDVLIPPPSINPSTVPASDLERLALESGAEIVLKSNCFEAHGSDTAVRDAIARVLELDIVQGFHHEIRFQVELANEHRDFISGKKNGKINKIMKSANVRIKYETLSEYNFLIDVAGSDLGALSGLSMLQEELPAEMSFHVPEVYHKRIIGVGGKNIQRIMKKFGVYVKFSNADEFAALGGYCDNEDNVISRTPAKNAMNLENLKQSVMELVNPKDKDYTNESILIPRKYHRTLLGEKSIFLHDIESKTGCSVRFPDKELATDSVAIFGPEHQVNVAKTMVLDHVPFEAEYLTPRSNEIRNAVNDTKFIELVNSLRSDLHVSISAPAQLLKSTENGQNTPPQSSNSDTASDDEEDLAFKVRCQRSNIDMLGAAKETLEDYLKSRNVPVHTRPSAPVQQPMRADALAGAFPLFNSKIIPAAESPTKESFDGFQDASAQFTRPGESRYHPLSNNSIGGGSSAAALMGQKPNFTGSSTLGGIKTGAVGSGRRLRAAVSTPNVKALFGNDSSGGYPGSAMSSPDSNTALSSPYGGIGEDTSSPATAAQLQQAQAAAAYYAAASQHAQEQHYTQNVWGPPTPPTQYVRPIPTAADATKSYAQTTEEAVKRGSDSVLESKLKTQPQRTLASQRAQSLDLGALVGKTPNSTTVQGQNANAGGYAGVVGDPSSGSGSYSPSGTQSSNRPSPREFNKPQRASHLTHQPHYSLGGGPISGVMQQDQSIFGSSASLGGHAHTRSLPQVTPPELDQNPQSQFYSPISPPGNPIGSSASIYAHPTQPTGLRHARSLSTNPRNTLQNIPNPISIPPTDNSANQSNFSNPNSATSATFSSSQQIPSRIATPSNFDGLSSDQANEISRVLAQVRLDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA32</accession>
    <name>I4YA32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_69501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959086.1">
        <property type="nucleotide sequence ID" value="XM_006959024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA32"/>
    <dbReference type="FunCoup" id="I4YA32">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA32"/>
    <dbReference type="GeneID" id="18475592"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69501"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031345_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA32"/>
    <dbReference type="OMA" id="NTTMWDD"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="47754" checksum="22AD1CB855FE7912" modified="2012-09-05" version="1">MSAFKRREPTTSQQIKGTKVSPSNASLHLSSGSAAIDDLLGGSAGGRGGLGIGTNTINLVVETDPHSTYSDILLNYFYSQGLKSSHKLLSIGIDGSKSMWTSAGSTDNEKSDNEDSALDHNEGRGESKIAWRYENMKRFETSINQNYNDGDFLSTFDLTQNVPLSTINKAKERSLLKEIEVNDYDKLIQEIKHVCDDHNKNPTSVLRIAIRNLGNWEYGDKATDKVELFKFIYKLRSIVRSTKYAAAYISTHSDNIDKETLNRLLYILDSCIALESFSDAPHRATAFAPNHGLIHPLMTSRLNSLNSPSNRHSLLRGGLIAGENNLAFKLRRRKLVVETLHLDVEGGKGERRTTPSNSSISVEETQERIKKANLHEGHNHTGNEVEIESTSSTVRFANDNDEETPPPSTKKKGPRRVAFQSDKPELYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA43</accession>
    <name>I4YA43_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959097.1">
        <property type="nucleotide sequence ID" value="XM_006959035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA43"/>
    <dbReference type="GeneID" id="18475593"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69510"/>
    <dbReference type="HOGENOM" id="CLU_008203_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA43"/>
    <dbReference type="OMA" id="DRWVMSI"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="306"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="542"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="721" mass="83076" checksum="17C2FA3FAFC7497A" modified="2012-09-05" version="1">MTTNESLNAYAEIHKYPTRKQLNGNEYEDAPDTVLSTQSSSSSISTQRSSPSTALKDRVLCRLAWSKREDLPDLFDERASVKFTLDRCYKWEESIAIYRENQVVDIYSNHSIPFRRSKDVKYSLDMLSDDTTISLYSATDFTLCMRSPPPKHHIPRRVAGTNLVFLKFKTTSIAKTWLWTLWTIKNAKRLPKELDVKLPNLGAHMRFPLEGKVTAQEIVRKCRTYITKIDIRGITPEKSSQTKLALCWRRGKFGLEWLSERATSEELLVGCCMMQTQQFPRLEVRRMAFENASIRYDINNTIYPPKPVEGHLSRITLISQKRVKTYLSTHESLIFLLKSSTAALKPSHDSENDKLRCCKQIREAVGFIDMRHIVSIRRVYDHKLEHKDKYPAYLDDTLFNGNVHPDRDNKLEGDTGGEEIFASLSQSEKHELHHRRQFELELISGHFAKFEAPSVALCFEWIRSLGELCLYWNKRTRKDARLLMEISNCGLGAPNTANALNQTVLPTTNDEDETPRVEDPDAGGPLLSHLWNWTVLNNVKPIMKIGKCFMRKSFRGTWSEYILILTADGMLHRWNIAPLNPAKKSKKANEILNRKKSTISLHHTFVLTSDDMILVNSNQDEGTEPSRGYRTTSKRAAKAPDRLYDDGYIACESEPSELAFILWCRSKSKKSVESLDKKAEKFEIRTRSRLERDHWCWCLEVIIDKVSEQNNDLLRNVSGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAQ5</accession>
    <name>I4YAQ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60692</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959033.1">
        <property type="nucleotide sequence ID" value="XM_006958971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAQ5"/>
    <dbReference type="FunCoup" id="I4YAQ5">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAQ5"/>
    <dbReference type="GeneID" id="18474103"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60692"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="I4YAQ5"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="36225" checksum="8EDB7007F26FD767" modified="2012-09-05" version="1" fragment="single">MIQDCLDKITSNTPTFTLAFALLGATVAGITLLRLLRLFFDVTIRKGISLKKFGAGKGTWAVVTGATDGIGREFAFQLAKAGFNIVLASRSAEKLGAVAADLESKYNIKTKTQSIDFSAGDDSSYDALSNSIDGLNIGVLVNNVGKSHEMPVPFEQTPLDELKAIVEININATLRVTQAVLPKLIERKNGLILNIGSFAGTVPTPLLATYTGSKSFLLSWTQALGEEVKSKGVTVELVNTYFVVSSMSKIRRPSKLIPLPATYVRSVLTRIGLNGGSISRPYTSTPYWSHAIVDAILSLSGFKRLVLWYTHKMQKDIRQRALRKKEREAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS9</accession>
    <name>I4YAS9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vps5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32827</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958756.1">
        <property type="nucleotide sequence ID" value="XM_006958694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS9"/>
    <dbReference type="FunCoup" id="I4YAS9">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS9"/>
    <dbReference type="GeneID" id="18471567"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32827"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022783_1_2_1"/>
    <dbReference type="InParanoid" id="I4YAS9"/>
    <dbReference type="OMA" id="MLVNHRK"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="483" mass="55212" checksum="BE4FAA2A535FB8FE" modified="2012-09-05" version="1">MDSIDDNPFADLQSSFAAPKEVKEDDIKQQFKEVSLDEPSPANDDSKLDNDPDYAQETIKESTPDNHNDGTNVVNDDDDNESLSERKRSLSLQQSQRHTASVIPVTETIKLPNGNTYDISVSDPQKIGNPANSYVLYTIRTFTKMPAYRQNSMTVLRRYSDFLWLYENLCKNNPGVFVPPPPSKQAYGRFKMDFIEQRRQALEKCLMKCANHPLLSKDEDLKLFLESDSFAVDVKQRQLDKAEGKSVLASWGSSIIGPKFIESDEWFDSEKQRIDGLEVQLKALVKALQNVSAQRYDLASSLAEYSESLLELSRQFIHSDELTKLFQMLADLSAQSKRGLDELVKNDASSFAATVDEYMRVIGSIKNTFSTRIKLYHDIRAAENSYTKKKTTYEKQKSVGQIHQYNIAYSLKDLAASEHSVHESKREFSRVSILIKEEMAAFDKLRMEDFKVSLKDLVSTLLKSQRSIHESWLNYERELKVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAV5</accession>
    <name>I4YAV5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_38815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958778.1">
        <property type="nucleotide sequence ID" value="XM_006958716.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YAV5">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAV5"/>
    <dbReference type="GeneID" id="18472083"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38815"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAV5"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1621" mass="180877" checksum="A0538F622496AAEE" modified="2012-09-05" version="1">MGVSQSRSFSLDSFVTEIGNDVSYDKSLGNSRFLKAIRGKSRSGRIVVKVFTKADPSVNLQSFIQRLKKEKSQLVGITNVYTFQTFLETDKAAYKIRQYIGTNLYDRVSTRPFWTPIEKKWVAFQLLVALQDSHTCQVAHGDIKSENVLVTSSNWVYLTDFASIKPSHLPLDDPTDFSLYFDTSARRTCYLAPERFFDSDSEIAQLRQLILEKGASNVDTQDKLVVTEAMDVFSAGCVIAELFLEGTPLFTLSQLLRYKEGNYDPTSVIEKIDDDAVRELVVSMTQIDPGNRQSFSGYLVDFRQKLFPDVFYAFLHDYCAKLLEPVQQPANPTVVAPSNTSAALFDTTQPNAPTTIPNHMKDVPEERIEKMWNDWLEISSNFDERYLQIKEDVDNEDHVDSAIFPVQLSIPNIKPSYVVRKADAHSSSDEDDTALLISTLLCSNIRDCLKPTSKIKALELLLTVSCYLKDETKLDRIIPYMVDLLSDTNANVRAATLRTITQILLIVGGITPANSTVFIEYLLPLIMPLVTDESELVRSMFAQCISPIAETGQKFLDLAESMKSNNTYTANEGVEKMLLDGNESFENSYEASSQDLQMFIQDAVATLLTDKSSMVKRSLLQDIIPLCLFFGPAKSNDLLLTHINTYLNDRDWELRSAFFDSVVGIATCVGGKCVEEYILPLVIQALADPEENVIVNVLNSIRKLAELGLFKKVHIWELIGMTFALLVHPNVCIRQNVIEFISAAVSRLPETDTWCIIYPQLTTLLSGQISRVDVDSLSEAVLPPLSRKLFVIAQEWSLKVPKSPFWKTGTSTSPIGVKEGLRSLRASLYQSGSQVSPKVDTHICDEDKPFIDRMTLNGFTKEDEVKLRYLRSHIMMLAKAQESKLSEVQRMPQPDINNVIALSDLKVAPQTVFIGLRNSNLVSGTLEANFKSRSNLSKQRSIESWSRQISTLSQRSTPVSEYAKPPVQIPNRGDVMDLRKRLAQPPASVQALAEPTKAMDVSRRESTTTLETMHSTSPKMADLPGFDGASPPEPGSHAGSPLISYIRPPRRGPLPSDGQKAAPAIGSISTNALGMLEIPRRDNYDDGGMNSGGATPISAGGIISKAKLPSNQTQYHHTYEGKDPAILMMLDNVCKESLKEPLSEFGNKVTPPLLKRKKSAVLNDDDGFSMRMVGQFKEHTSAITSIVVSPDHLFFVTGSSDHTVKVWDTTRLEKNVTSKSRHTLKRSEAVKALCVIQDTHCIAVACKDGTIAIFRVDVSVGTNLPKYASELCIVREFNVKFASDGEYITWMFHYSNDLSSNLVYTTSFSRLCIVDLRNNQDMLELEAPVSHGPILSACIDSTRSWVVTGSLFGHLCLWDIRFGMIVHTWMSRREGSINQIEIEPSSEELILVSVSDTAMSNTVIEVHNVATKQVVDVYESQPLGECKRGKERQNDSTVKAIDDIIKVGKETQNTVPLESESARSFLIGPASKKSGGMWYSYATAQAHAAAQLNTSAWVLEDSKNKNARKERKKFLIIGTNSQQIKCWNLDSDWHKSKILSGGHKDVRYVMRVDDDGRELHCEERVTQENKRTNRSLLVNEQNDRLLSSHNQSVEALAAIEVPFRALISGDRGGIFKLWRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB36</accession>
    <name>I4YB36_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_69325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958851.1">
        <property type="nucleotide sequence ID" value="XM_006958789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB36"/>
    <dbReference type="STRING" id="671144.I4YB36"/>
    <dbReference type="GeneID" id="18475570"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69325"/>
    <dbReference type="eggNOG" id="KOG0278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_6_1"/>
    <dbReference type="InParanoid" id="I4YB36"/>
    <dbReference type="OMA" id="DGFYGLW"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="314" mass="34712" checksum="0939D91D58A96F33" modified="2012-09-05" version="1">MSRSIPLTCSGHTRPVVQLQFSVLQADSTFCLISSCKDGNPMLRDWTGDWIGTFLGHKGAVWSSKLSHDTTLAVTASADFTAKVWDTYNGTCIHTLPHQHIVRSAAISPDGSHILTGGHERLLRLFDLSAPEQSTFLQTSDQDSSAHSSTIKSVLWQDAAMAVSGSEDGTLKWWDLRSKRSFQVYQLDSPLVYLEWSAGAHMMVAVAGNTVYFFNAKQPGQVIKQFNLKHKPSCASLHPIVMDKFVVGSADDTWVRIYDFNSGNELDCFKGHHGPVHAVEYSPDGEYFASGSEDGTIRLWQTNPGRAYGLWRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB52</accession>
    <name>I4YB52_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_54758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958866.1">
        <property type="nucleotide sequence ID" value="XM_006958804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB52"/>
    <dbReference type="FunCoup" id="I4YB52">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB52"/>
    <dbReference type="GeneID" id="18472691"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54758"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB52"/>
    <dbReference type="OMA" id="QQKDHIF"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="360" mass="41027" checksum="04C4ED16767EBDE2" modified="2012-09-05" version="1">MKKKVLLMGKSGSGKTSMRSIIFNSQSSDSTSTVQATLSIEAQSLQLLSSLSLNIWDCGGQTNFLSSYISHQRADVFKDVGVLIYVFDVTTPTNQSSDELSWFSQCLEGLKEYRKDNDSLKVFILVNKMDLVSKQDIYAVFNRRRNEIFQSVDQIIKYNDNIEVECFMTSIWDQSLYKAWSKIVTKLLPSSSKMTGALTHFARQAHATEVVLFERTTFLVIGQTTLNKYGEEEIDLEDEDDNDEEYINVTNRNIKLSRHRFEKISQLIKSFKHSCSKLNNQFNSMQISEKYYNAVLEPLTVNTYILVITDNTNISPSAIQMNIRLAKPYFEKVEHSFIDTNTASQPTSSSSSIKSEKSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ8</accession>
    <name>I4YBQ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_7086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958411.1">
        <property type="nucleotide sequence ID" value="XM_006958349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBQ8"/>
    <dbReference type="FunCoup" id="I4YBQ8">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBQ8"/>
    <dbReference type="GeneID" id="18475803"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7086"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_6_0_1"/>
    <dbReference type="InParanoid" id="I4YBQ8"/>
    <dbReference type="OMA" id="ESFANIC"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="22181" checksum="BB98E7E8DB93CBD7" modified="2012-09-05" version="1" fragment="single">NLYLIVTLNKMKSHSNNKPVSIPIKNSLIDPRSDDLLLIVKDPKKTSVDLLDSNKIKFISEVVDLKQLKGEFKSFESQRNLFSQHKLLVDQRVLHLLPRFIGKHAFNNSNKPIPVDLESKNLKSHLESRINSLHFTPSKGVCQSIKFSTTEQSHEQQLENLNSCINYFIENIDSLENIKSINIKLSSSDSLPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBR5</accession>
    <name>I4YBR5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_64361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958438.1">
        <property type="nucleotide sequence ID" value="XM_006958376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBR5"/>
    <dbReference type="FunCoup" id="I4YBR5">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBR5"/>
    <dbReference type="GeneID" id="18474918"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64361"/>
    <dbReference type="eggNOG" id="KOG2760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015433_3_0_1"/>
    <dbReference type="InParanoid" id="I4YBR5"/>
    <dbReference type="OMA" id="YAMYNKS"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="472" mass="53456" checksum="8DE652B9696A2859" modified="2012-09-05" version="1">MIKLNITNEQVKINLNKKENVLFTNNNVGIYLNDNKDSQRQFGSIYATNYRLIYVDNNNQSKSFTINLENISKTEFYTGFLKSSPKVTIYLKNMVNKDNKNDWICSICSFLNPIDSISCNLCGVVKDTNNSNRQNARNKSQFDNSCPKCTFKNHPLMTRCELCETTLKPLQSTTPTITPEFIRVSFRGGGEGQFYSTLKLVLEYKAWSIEDPNDKVLQRDQSAGIGGILASVDTKVQSSQSNIVDAFKDLQTLFLKADEMVKCADQLASRLPKNKEQMTDVEKEAQYFLNSSFNDINLGIAPTATSDEESLAFELKAILHGDSGLLSGNKRNVINLDEVWCAWNRGRGVALLNPKVLIDILPYIERTTNIRSLKLQSGIIVLHNPSHSLEEFNKRLESYIEDCRGGVTTIEIAQKEELPPSLIEDFILCAQAKFASVVKDVSSGGLVRYWKNEFKDFTIENELNDYFVNWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV1</accession>
    <name>I4YBV1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_38405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958473.1">
        <property type="nucleotide sequence ID" value="XM_006958411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV1"/>
    <dbReference type="FunCoup" id="I4YBV1">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBV1"/>
    <dbReference type="GeneID" id="18472060"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38405"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBV1"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="25832" checksum="04BBAD94E5C57113" modified="2012-09-05" version="1">MSLKERLLDVRQNINKKSSTATLIAVSKYQPVSKIKEFLSYHQTDFGENYIQELERKSKELQGSDIKWHFIGKLQSNKLKSLAAIPNLKSIQTLEKLSHAKKLDELLTKQLDIFIQINTSNEDNKGGLGNHSSELDDLIAFLKQSKHLNLIGLMTIGSLKESTADSEVNNDFMRLVDTRNTLNQRHGLNLKLSMGMSADYIRALDYQSDFVRVGSLLFGERPQKHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ0</accession>
    <name>I4YBZ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958511.1">
        <property type="nucleotide sequence ID" value="XM_006958449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBZ0"/>
    <dbReference type="STRING" id="671144.I4YBZ0"/>
    <dbReference type="GeneID" id="18473955"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60456"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642828_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBZ0"/>
    <dbReference type="OMA" id="NIVHMFI"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="427" mass="47848" checksum="E49D0F731B3665AF" modified="2012-09-05" version="1" fragment="single">MSSAEPENKKRRRMQSENEKENNKDNSPTNSFADHSAPRGGRAFAIEVDKAVNERMAEKDKEFDRVNGEIAFKNSLLDSQSEYLKKINNILHCSICMEHMIEPYGLSCGHVGCYECLHAWFTRSIEDDNHRKAKVCPSCRAPIRARPNELYIIKELVQIAALANNESISQPPQRTGDVWEGVFRSGGEYGPIEDREDGVLRCGRCSGELLHGICTMCGEIYTDAEDEDEEEEEEEDEDEEVYADPADELERVSRLNLPFSIIGVSDSEHSSQRTESEEHDSDSDGNEHPRNSQNHNDENIWRGIRENEESESESDDFISDGGSVESRNRSGSRGLGAPVEYIHSDDEEEEEEEEASSTSSSSSSSRQSESESESEASSSSREVNPTRRHNAGVIELSDDDNSGDGIPTSIPPRSRRRAIISDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC22</accession>
    <name>I4YC22_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958542.1">
        <property type="nucleotide sequence ID" value="XM_006958480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC22"/>
    <dbReference type="STRING" id="671144.I4YC22"/>
    <dbReference type="GeneID" id="18473970"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60474"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678272_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC22"/>
    <dbReference type="OMA" id="HTNEHIG"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="43630" checksum="6DC2B73D2CD5C281" modified="2012-09-05" version="1">MPALRTATSTPSFGVTRRHPASLMPVTSHAPALVDLMRSPISERMVDALAQKVSEIIPVRPDSNATNSPDYTHNNGYPSPPPSPVKPRLARVGHVAAEMSRGPPPLKQFIKTVLIESGCQVATVLCTLVLLDRLGKKLPPAAKGMPCTRHRVFFAAMIITAKSLNDCCPKNRHWRKYAWSSIRFALEEIHLMEIQLLDLLEFNIGFNEAELIRHSKQFMRMPLSNQNTSPPQFKPTPSAKAPTPLKPALKTAKSMPAVRQVQQPLMSRNTGMPGAFSPSALDQALRAQLPSDMTSKRVSKDMSVSSSSDGGGSLPATPSDVTGLNKPTLALAMALENRKGAVDDDEELPESLTMLPAHLTAPAKSMHAPGIAGLISRIMKHPAGNSHSHNNHRRNQDSVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC70</accession>
    <name>I4YC70_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958261.1">
        <property type="nucleotide sequence ID" value="XM_006958199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC70"/>
    <dbReference type="FunCoup" id="I4YC70">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC70"/>
    <dbReference type="MEROPS" id="M20.002"/>
    <dbReference type="GeneID" id="18473882"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60314"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="InParanoid" id="I4YC70"/>
    <dbReference type="OMA" id="DWTHHPF"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="283"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="563" mass="63205" checksum="918AD901F00DDC1F" modified="2012-09-05" version="1">MMSEKQSTSQSLPRPAAEAVKKPDSSWRRPIVVGLILSFYLLSKCTLLVDKVADSELNDEFNSPVHCPSQSPSLPNAEIEFTTPEGSIERWSESVTYPTVSYDDFGEPGVDKRYETFPPFYEFLKKSFPLLHSTLSHETVNKYGNFYEWKGSDSNLKPLILMAHNDVVPVPSDSLDRWDYPPFSGVIDKDGWVHGRGVGDCKNLLLSIYEVVESLIKDGFEPRRTIILSFGFDEEISGPEGAKYLSEHILNKYGEDSALAILDEGGVLDLESYDKPFALPAVKEKGYFDVKISVATAGGHSSVPKSHTSIGYLSKLIGRIEDQPHKPHLAYENPFTTHLQCIVQHSPDSLDEGLLKDLRDVRKWQDAADRIAERDLKERYLIQTSQAVDLIQGGVKVNALPELATAVVNQRIDVAGSVNEMKKHITELLKPYVENELNLNWIGFDNKSAPNDESNGSVKVETFGSPLDPAPNTPTSGKIWDTLVGTLKNVFGDELIVSPHLMNGNTDTRHYWKLTNNIYRFEAFDESLSRDIHTVNERVHKDAHIQSMTFLHQFIQQIDKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD1</accession>
    <name>I4YCD1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Chromatin Elongation factor SPT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32534</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958318.1">
        <property type="nucleotide sequence ID" value="XM_006958256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD1"/>
    <dbReference type="FunCoup" id="I4YCD1">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCD1"/>
    <dbReference type="GeneID" id="18471512"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32534"/>
    <dbReference type="eggNOG" id="KOG1999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252523_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCD1"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="181"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="616"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="832"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="1169"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="771"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="835"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="921"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1221" mass="132871" checksum="24E6C0A176E3EB7B" modified="2012-09-05" version="1" fragment="single">MDIEDSKPDLKTEDIEDKVADADSPTVERVNDDDDDEENPIEDRIVEEDDDEEEPEEAEDDDDDEDDDEQDRATKKKRRQNNPKNRFLDVEAEVDDDEEEADDDDEGAGKDLEFIQYNDEPEESSRDIRGGHTRLDRRNRELEDQDAEAVAESYKERYGRMRYQGEMNQVPQRLLMPSVEDPSLWGVRCRPGREKDIVISIMSKFIANEWGSQPLEIYSAFCRDSIQGLFYVEARSPSHVLEAVKGLVGVYSSSAPDRKPLLIPVDEMADLLKIKKQVKEVKPGSWVRIKRGKYQGDLAQVMDITENGEVAGVKFVPRIDLNPKEDSTSAGAAGKKRKKGANSTVSFRPPQRLYNHADIVRVYGSRTSVKRGDKYVFQNDTFRDGLLEKDITISGLQTEDVNPQIDEITKFASQNGETSSGGDIDLNMMADAVKQSAAILQPGDVVEIFEGQLTGISGSIVALRGDVVTIKANVDEYSNQHIEVLSRSVRKTFSTGDHIKVINGKYTDETGLVISINEKDSTVTFISDMSQDELSVFSKDIRVAAEIGAAHNTVGNYELHDLVQLDQQTAGVIFKTEHNQFKVLDHNGNVRTVGPRQISMRRDSRRAVATDSENHDLRIGDMVKEIQGEQRKGQVLHIHRSVFIFLYNREISENNGVFITRSTMLASVAPKTLNNSSVDLSQMNPAMSSISPQQREKGGMVGSQMLGKGMRDKLADIPVQIIRGSYKGMIGVIKGTNGNQIRIELTTNSKIISLEKEMCMRRHNNQLVSLDTYVGPPRNQQNGGDRFGAHPRDSSMASGGGATPRGYGNATPWQGGGKTPFGQGGATPWGAGGRTPAAGAWAAGSKTPGVRGGATPGWGAGARTPAAGAWAAGSKTPGVRGGATPGWGAGARTPAAGAWGAGSKTPSWNAGSKTPGGAAWGNNTPGQQLNDLNEQNWGSVSPNRYSNAASSNSPSRDKSSSGFQKPSDRSNEVSSFDDRQGNAAWESIHNDGESSVDISSMSLQNKDTSWDTQDDYSAPTPYGGAPTPYGGAPTPGGAPTPGVGYTPGYSAPTPGGGGLAPTPYGAPTPGGGGYASTPYDSSSGPQMHSSRMQIRHGPPVNWFRDNVDIKVKIDSVRQFEDGKFDGKYGSLLRCNAYDNVIVKLLDESNNEKITLSNRFISPVQPGDSAFDKGQNAMVIEGEYKGELAKLISNDEDEWMVKVFPSGEEKFLNTYSMAQHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU6</accession>
    <name>I4YCU6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958094.1">
        <property type="nucleotide sequence ID" value="XM_006958032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU6"/>
    <dbReference type="STRING" id="671144.I4YCU6"/>
    <dbReference type="GeneID" id="18475458"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68714"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066075_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCU6"/>
    <dbReference type="OMA" id="YPEDHAK"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="27246" checksum="1A9527FED5D61565" modified="2012-09-05" version="1">MTLNSRLVLYTSLICPYAQRVHAALEQAGAKYDKVEIDLKNKPEWYHQINPALKVPALVVDKDAHSKDLEKVPESGVSVNESLVLLELVADLFPDAHLLPHGLVNAVNRAKVRLFIEAGNAFSSAYFGWLIRGEPATNILTAIEGVQAHLPETGFLLGTDRPSIGDLAFAPFFIRFKSFAENSNHSEVDIAGGKQLLETLKTEKYSKFYKYINSLLDLPSIQTTSPDAKLIVDRFTEKIAQLKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD41</accession>
    <name>I4YD41_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_68792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958184.1">
        <property type="nucleotide sequence ID" value="XM_006958122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD41"/>
    <dbReference type="STRING" id="671144.I4YD41"/>
    <dbReference type="GeneID" id="18475474"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68792"/>
    <dbReference type="eggNOG" id="ENOG502RZTX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059962_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD41"/>
    <dbReference type="OMA" id="MVMDWRE"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26792" checksum="95D6ECBFE345CEC7" modified="2012-09-05" version="1">MAKAQKFDAALLIFQIVAVQSIHYLALSIITPTLLTLFANEEGLRYEWGSPPLSVGLILDWRELANWEHHEAVWQGLWIKGKQSGYSDDIYEWDGNHNRRRGWLLAISWVLACFIDIIPLYYLVRKPTLILDFAVTMTGLHFLFTTAHVQSPPLGFFCYGIYALGVVVLVVGAEQLAMRRELRRGLWGDRQDDYEMSTRRNYNQHRRANQRPAGLGLVLDSPDINYETTKVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD69</accession>
    <name>I4YD69_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_18072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958025.1">
        <property type="nucleotide sequence ID" value="XM_006957963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD69"/>
    <dbReference type="STRING" id="671144.I4YD69"/>
    <dbReference type="GeneID" id="18470752"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18072"/>
    <dbReference type="eggNOG" id="ENOG502S2NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1112063_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD69"/>
    <dbReference type="OMA" id="YSERITY"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="203" mass="23635" checksum="1F96D27E5016CA4F" modified="2012-09-05" version="1">MTRQTASKRSWCPPPDQITYRELLRFEERLKQNATALRKRRRRYECKIKVFLLFLISTSAVLAWNVIDKQNSSRYVPHCNRALRSFNMALNMRLMSPSTPFSLFRRPAKAAKVASQQRQKAMSSLPPTTNPRGELVFSHRVDKSFRDGYDKYRAAFERKRTQALAAKNTSKMPQVNVNIPRQTAPHNRNESFSFLLNDKAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD76</accession>
    <name>I4YD76_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958212.1">
        <property type="nucleotide sequence ID" value="XM_006958150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD76"/>
    <dbReference type="FunCoup" id="I4YD76">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD76"/>
    <dbReference type="GeneID" id="18475477"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68820"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043850_1_0_1"/>
    <dbReference type="InParanoid" id="I4YD76"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="250"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="372" mass="41577" checksum="5771C641A234171C" modified="2012-09-05" version="1">MLSSIFRRRNKNTDFESTLNGLSSDVIEHQAKLADIRVRERRASLWITTTLIVIWALYLGFWYLGLVDWFISVDENGVGSGLYKLLAWSGVVVGPFMTLFARRIAKSWYTRIGSQEETRLRDLHTSLVKTLEEVKVKAPYNEARSLLERYGTTVGITIHDVTPSTPTSTPMKAKHLSTPLPSNTPSKASKELPQTPSPGTPSPANMQQMQINKLQPQIPQSDGTLPTTPGKASQQIIPQQIASPVRERKWYDRLADVILGDDPSSTSGDISQRYALICEKCAKHNGLVPREQYIDLQWECRFCQQMNLSPRRKALARQIQGNNGNSNKLKPSPLSQASVQPSEEPKNVTSKEESEDKNEKGDAKPLPLPSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDC1</accession>
    <name>I4YDC1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_7356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957736.1">
        <property type="nucleotide sequence ID" value="XM_006957674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDC1"/>
    <dbReference type="STRING" id="671144.I4YDC1"/>
    <dbReference type="GeneID" id="18475824"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7356"/>
    <dbReference type="HOGENOM" id="CLU_108156_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDC1"/>
    <dbReference type="OMA" id="AARHSIM"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="131" mass="14599" checksum="E1C33452531542E7" modified="2012-09-05" version="1" fragment="single">FKVYGYPLSESEIIAVCQSPPNDSQRERGLYIQPLQKQSAESLRMKKKTNRASMMSVMSGLGAVPEHDEKPLYESAAQLPSVNQADRVANPRGRLQNFHGQRPPSELISTHLADFFPTADIKSINKTARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDJ8</accession>
    <name>I4YDJ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957845.1">
        <property type="nucleotide sequence ID" value="XM_006957783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDJ8"/>
    <dbReference type="GeneID" id="18473768"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60143"/>
    <dbReference type="HOGENOM" id="CLU_054259_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDJ8"/>
    <dbReference type="OMA" id="THERSPI"/>
    <dbReference type="OrthoDB" id="10368767at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="271" mass="29840" checksum="941DBD86597B1D82" modified="2012-09-05" version="1">MLVLDPLNRPKETKGKQQRRRSSILRALGRGGIPADAGVEQRRKASLVPLLDEPGQMDAQGVRRKSSIVEAIKRRPSVEDGEVNDEGRPQFNLDWQNENGGLSRSPQPRRWSTSDSDVSEYRPFPLYIHDKVLTSVAIPFSQIVSIHTTQLQRGVPNVTPPGSPKSRKASLAFETPEGGKSMEGPRKIAEKPATIEIQVKKGPNAPNLSNTADGTISIEFWDSLSGQIEADVILKYIQMVRMNSNNAPDDVRHAAQDLVHRESQGGQAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ6</accession>
    <name>I4YDQ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957901.1">
        <property type="nucleotide sequence ID" value="XM_006957839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ6"/>
    <dbReference type="GeneID" id="18471448"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32252"/>
    <dbReference type="HOGENOM" id="CLU_1344169_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDQ6"/>
    <dbReference type="OMA" id="GFGHIEN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697636" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="204" mass="21143" checksum="4D7E6FB1B39C9387" modified="2012-09-05" version="1">MFAKVFTAGLIATSALAAPVARSDSLTSVVQGLGSNSDFTSALSSLETLNSQDSKPTSDDISSVVNQLTSAFKSTNDQMATADTSDVDPNGLGKYLADDIQNIVNHLSPTLNSVVGEDLGLQSILQPLDDEISSTLSGLESDVTNVQKILYGALNDLGLGDVADLLNKTLNGELPGLLTSIDNELNGVLEHVPVVGDLLLSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU1</accession>
    <name>I4YDU1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_17734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957745.1">
        <property type="nucleotide sequence ID" value="XM_006957683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU1"/>
    <dbReference type="FunCoup" id="I4YDU1">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDU1"/>
    <dbReference type="GeneID" id="18470738"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17734"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_2_1"/>
    <dbReference type="InParanoid" id="I4YDU1"/>
    <dbReference type="OMA" id="FFCQMGR"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12822" checksum="C5F337AA77C8C216" modified="2012-09-05" version="1" fragment="single">CIHFSQRIDVREANEVIQGGIPSSVNLPLSNFEHALDLDDAEFRHLYGFDKPTNGIDDKRNFIFYCRSGKRSATACDLAIRRGIKNIHNYQGSYIDWLEQESKNKEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDX3</accession>
    <name>I4YDX3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_17885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957749.1">
        <property type="nucleotide sequence ID" value="XM_006957687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDX3"/>
    <dbReference type="FunCoup" id="I4YDX3">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDX3"/>
    <dbReference type="GeneID" id="18470742"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17885"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013365_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDX3"/>
    <dbReference type="OMA" id="DPGMRYL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="388"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="642" mass="71964" checksum="E31256638BC8E0F4" modified="2012-09-05" version="1">MSQSSQVMKTSRRGRPFVRDLHDLFSTMVVSLDLKTHRNIFKSYSNSFTTDEACSNLHNLKFSQSVRLPDPNNPSKIITTTSTTTFSMERQMAKGVCQIFMDAHLIINASDTSSRAFKDRGIYLITPKGLHVLERFISKNGISAEHLINVFSTQTICLKLLHLERRPIDDEILVNKQIINIVFRRFVGRQPNYSPESQPSKQSMDKDSDKGNGVPVNDIYMTKAAVSSEVADIHHTFASNAALDWLLDYTTIAGRDEAAEIAAHFVRYGLIRLVSEKGKRGDDLIVTVNYAQHPDDTVLECQFRAGSKCEYGITPAGRRAALWETGSTNESSDSLDRSSSSKHRDSHNLARQQSKAGGQLQAQYAHERTRDAAVAVASAHHKESNTGRLKQILDDPALRSLFREFLRSNFCEENLSFWLDVQDFKRKFSTTSSAVAKPQHFGLFSKSSDKKGGPSAMQQHQQDINAMACVIYNTYLAPSSSSELNIDHGLRAELVNYVATIKREAREKYGTEIKPDTNEDNGLGQIPLQASQISRLIVLYERIQAYIFRLMATDSVPKFVKTERFLNLMKTFEEYQETLIHDKSTPPVPPLPKENEGSNSSLRSHSVHSLRSSKKSHNSTEALANTTSNTSLGSKQSSREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ6</accession>
    <name>I4YDZ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_63926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957983.1">
        <property type="nucleotide sequence ID" value="XM_006957921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ6"/>
    <dbReference type="STRING" id="671144.I4YDZ6"/>
    <dbReference type="GeneID" id="18474881"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63926"/>
    <dbReference type="eggNOG" id="ENOG502SCUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2160362_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDZ6"/>
    <dbReference type="OMA" id="MEGVQDP"/>
    <dbReference type="OrthoDB" id="3364766at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="7">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12546" checksum="3E793AC8D333E42D" modified="2012-09-05" version="1">MSDLAEKKNEVGQPAQAVQASPEKVENKGKGKENVEDEEEDEEDEEDDDEYNDDEVDDDFEDEDMAEIDPSAIVDTGSRRTRSKVDYSSADARKKAELTDKEDDEDDVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH2</accession>
    <name>I4YEH2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_68341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957618.1">
        <property type="nucleotide sequence ID" value="XM_006957556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH2"/>
    <dbReference type="STRING" id="671144.I4YEH2"/>
    <dbReference type="GeneID" id="18475378"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68341"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444964_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEH2"/>
    <dbReference type="OMA" id="FCDHPVE"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="217"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="70366" checksum="5D929B6B727377CD" modified="2012-09-05" version="1">MNMIDLYDGNRYHFIQPEFHSIITQHLALAEKQQLLDIRDAGLGEDGFMKEFEGDHTIIFKLLIKVLRFLKDNSNSPLFEQFEYLPEQDQYFYSLVTDPFSLSELESNVNNGNYTTTKDFETDLFRVFDAFRLGSPVGSARYGNVNILQRFYVGLFAPSNLTLSQDFNFASVKAGPGNPYAEELAEGVPGMEGVGPATSRILTRHRQFKDDGHYRGLHLNMGDWVHIINPDDATKPIPAQLFKVFTPDYSTHPHITVCRYYRPEQTVHAPYRRFYENEVFKSGNYVDLPIEDLLEKTFVMFATKYSRGRPKEHLWDKRRPLYIVEHRYSPKSKTEDAGGFSKIKSWNACIPEEVRKTEYEMHYFDESQRPPLLPSPFLRGIEGPGRLDENAPPPEEIGQHAVANASAIAQQIGSLVPGTPSALAQASQTGATTYKKRNHKEAINQQAQLVHTGQQNDKKSQYKSHKIQYEKPAVKRDKKEKKLKNLDRSITANCKKRDIGQDGEVEFIPEETASYFETDGDSNKLKWFSGPPLNMPKRGQTTYSPKYLLHRLSNEKPRKKKQKILEQDVDELKIAFDEFFDKNLEQSRKLSPGPRLSASEALINFSDSLSEVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEM8</accession>
    <name>I4YEM8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADK2</name>
        <name evidence="10" type="ORF">WALSEDRAFT_60064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957665.1">
        <property type="nucleotide sequence ID" value="XM_006957603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEM8"/>
    <dbReference type="STRING" id="671144.I4YEM8"/>
    <dbReference type="GeneID" id="18473717"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60064"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEM8"/>
    <dbReference type="OMA" id="IKVENTM"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="25755" checksum="1F96AD40F930CA81" modified="2012-09-05" version="1">MRYTSILNASTKNMRLLLFGKPGSGKGTMSQKLQSYDVNILSAGDILRKNVRMGTPLGQKADKVIKQGSLLPDDVMLKLLTSELEKVHDYHWILDGFPRTIGQGQLLDKQLESNSINLVINLDVPDSIILDRIQQRWIHEKSGRVYNLGYNPPKVAGKDDVTGEALTQRDDDNVDTFKTRLNTYRSHTEPLLEYYQSSNRLETVSGKTSDEIWPQLNDLIKNKFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YER5</accession>
    <name>I4YER5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EIM22457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006957636.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="I4YER5">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YER5"/>
    <dbReference type="GeneID" id="18473729"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60083"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017632_1_0_1"/>
    <dbReference type="InParanoid" id="I4YER5"/>
    <dbReference type="OMA" id="MSTVNNR"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="592"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="682" mass="74312" checksum="DB7C567E1887FD2D" modified="2012-09-05" version="1">MSGTSQNRFSTSSSPPHTSLNPPNIQSAHSRSPSPTTGAYNKTAAAQLARNNQARQTFGAPSRTPVSPRVQRPASEIAQSAGGNTGWNQQQNQLLGSAQLPPGSAGLGMNTPDTLDQWFENLGSYEDTLEEMAAASLDQNFKEELVAIEQWFRVLSEAERTAALYSLLQHSSQMQIRFFITVLQQMSRSDPISQALFSPSAGANLDGQIDTELSRMSLKSPHLAAVSGISAKNSPNLAATTAINRQSLAAGEYHLSPEDALSAHRQRFNSKRTSAPGHLPGPGTIGAGSSTDNLRSPNWQRGSGLEQVQERRSPTPSANSERPKSSDSSSFVRSDSIQDLNDDQALAMAQANANISSPLQQSANWSSMVNTPSIGNFSINQNQNQNQFDTDLQNWYANVTNSGNNNNAVRLDDARKFRRQSRQSVNYDDVTSAQDDYNGVLNNGLLTPGGTSVGNNQTNQNLQQLLAQQQQLINSLSSPGQVSAPTSPNPGNPILALQLQSLHQQQQLLQQQQLALGRLQQQQNVRAGPGLGIYGGNNSTNGSRLPSPYKQSFNQQQLGIPPNQQGGNKRSISNQSRQRNNTTNNEDELDERVLNDVATWLRVLRLHKYTTNFQDSNWKEMVAMSGNDLEARGVAAVGARRKMLKEFEKVREKYDIPATPEQEAEMKEEKEKAANPTASGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YET5</accession>
    <name>I4YET5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_32153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957717.1">
        <property type="nucleotide sequence ID" value="XM_006957655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YET5"/>
    <dbReference type="FunCoup" id="I4YET5">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="GeneID" id="18471431"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32153"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="InParanoid" id="I4YET5"/>
    <dbReference type="OMA" id="RLNETKW"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="233"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="418"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="780" mass="89473" checksum="56AA143DC41F6158" modified="2012-09-05" version="1">MFVVKSLFGKIMGNETNPELIQLQSGQLNLVRPNSIKGSRECIYKDAVATVRRTTKEFNYQLVVTRAYEEGEEELLDEDEETDDERVFLIDPTLKFHDAQHEGQEAFRWDELNGDDGDTWEFVVDSNVVNAPTCSLFHLTVLQCMYERVHDKSSQSASEQDLEEFRFKPNRQSVYPDLNNKDLPVQPEQDAPETDQVEQPPQQEEEPVTEIQPNTLAEHLPTPEKPGEDWQPIFSSHAGLFIFDKASERFLMQAEHVDIEIVEAGRFLYWLIVKNPEDGQLWLTQPIDSTMNSKNDLETGSFMWNYYNSGKTHTWLLRFYEIDEFVKFCERFAQHMWEHLNETKWEKAKDDEQKFVKQSHDQDVEMLVIEDEEEEEPEEEEEFDEQYQDEQDEEEAEKLIRGGAEEDSDNEEPISKDPNSLLSMGYTNDRSFVVRGNNIGVYKQGDDSVDFVGNIKDIARPNGQIFTPSQMMLHGQDRTMVMMDKSNKGALYNLDIETGKVVDEWKMNEGVNVNNFLPDAKFAQMTPNQTFIGTSHNAVFRVDPRLNGKEKMVDSQYKQYVSKNDFSAATTTASGKLAIASNKGDIRLFDQIGKNAKTQLPALGDPIIGIDVTSDGRWIIATCKTYLLLIDTLIGAGRYQGALGFDRSFPADAKPIPHRLQLKPEHVAYMDEEISFTPAKFNQGESIDETNIVTSTGPYVVTFNFKRIKQGKLDAYKIQRYDDKIVADQFKFGGDRKILAVQPHKVMQLDRRQLSRPSRQSISTPTKSLKSRSSIVDSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV3</accession>
    <name>I4YEV3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_32166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957734.1">
        <property type="nucleotide sequence ID" value="XM_006957672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV3"/>
    <dbReference type="GeneID" id="18471435"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32166"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEV3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16462" checksum="E93CC753B00B071B" modified="2012-09-05" version="1">MRRTMRERYAAPLKIEASKLSVIKSNTSKTSAGKLTAAKTAKILNELPRATCHFPTTKSYRYRFKLIDSPKCSTCGIDDSILHRIFICRRHIMARITLRRKITKINIRFELGPMFRNAQALQAPYEFFKLQLTTYPRYSGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEY0</accession>
    <name>I4YEY0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="10">2.1.3.2</ecNumber>
            <ecNumber evidence="9">3.5.1.2</ecNumber>
            <ecNumber evidence="8">3.5.2.3</ecNumber>
            <ecNumber evidence="26">6.3.4.16</ecNumber>
            <ecNumber evidence="7">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="39" type="ORF">WALSEDRAFT_31765</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="24">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="10"/>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EC" id="3.5.2.3" evidence="8"/>
    <dbReference type="EC" id="6.3.4.16" evidence="26"/>
    <dbReference type="EC" id="6.3.5.5" evidence="7"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957194.1">
        <property type="nucleotide sequence ID" value="XM_006957132.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YEY0">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEY0"/>
    <dbReference type="GeneID" id="18471365"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31765"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEY0"/>
    <dbReference type="OMA" id="WSPFNGK"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 35" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 35" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ATP-grasp" evidence="37">
        <location>
            <begin position="613"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="37">
        <location>
            <begin position="1151"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="38">
        <location>
            <begin position="1408"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="1891"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="36">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="36">
        <location>
            <begin position="1895"/>
            <end position="1917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="EIM22522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2260" mass="247616" checksum="CD35EF2D78B66B26" modified="2012-09-05" version="1">MSGAPSPPSNPLELAPSQPPAAHALAKQSTVRNNNGILYPATAQPAGVESDYDTALELEDGSVNFGYSFGAKGKSISGECVFQTGMVGYPESLTDPSYAGQILVLTYPLVGNYGVPARPAETNPLNLPEEFESAKIHVAGLVVSTYAPDYSHFLANSSLGTWLQEQGIPAVFGVDTRNLTKKIREKGVMLGRILARKNGDRSGRPLLSQPAASLSRSVSTASMGSAVVNDSWKEDFQVIPFTEYGNTNLVAQVSLPTPLIFKPTATPLKHPKEDRNVRILTVDVGIKYNQIRCFNNRGVEVKLVPWDYDFLNESEPYDGLFVSNGPGDPATVTPVIEKLRTAVDQTKTPIFGICLGHQLLSLAVGAKTKKMKYGNRGANIPCTDMQSGRCYITSQNHGYAVDADTLPEGVKELFVNANDGSNEGTYLEDKPVFSVQFHPESTPGPRDTEFLFDVFINSVVDFAKTGVKKQIVLPGGTLADNAAKYPRVDVKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKQEGIYTVLVNPNIATIQTSGLADKVYFLPVNPDSVRKIIKHERPDGIYVTFGGQTALNVGCKLKDEFEALGVKVLGTPVNTIEMTEDRELFARAMEEIGEHCAPSASANSLDEALQAAKNIGYPVIARAAYTLGGLGSGFADDEKSLTQLCNKAFATSPQVLIEKSMKGWKEIEYEVVRDCRDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDADYNMLRSTAVKVIRHLGVVGECNIQYALNPHSKEYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEIRNSVTRSTTACFEPSLDYCVVKIPRWDLKKFNRVNTALNSSMKSVGEVMAIGRSFEETIQKAIRCIDDRFYGFGTNPFVMEKAEIDEELVNPTDRRVFAIANAFVKGYTVDQIHKMSNIDRWFLNRLKNLIEQEKILSEFNTTNVTPQLLRQSKQMGFSDRQLAKFLGSNELAVRRLRQESGIVPHVKQIDTVAAEFPAFTNYLYTTYNAGASDIDFEDKGVIVLGSGVYRIGSSVEFDWCAVSTIRTLRSRGVKTVMINYNPETVSTDYDEADRLYFENISLETVLDIYDAERSTGVILSMGGQTPNNIALPLYRQNVHIYGTSPEMIDTAENRYKFSRMLDKIGVDQPQWKELSSFDEAYKFCQNVGFPVLVRPSYVLSGAAMNVVSSPDDLENYLTQATAVSQDYPVVISKFIEDAKEIEMDAIAKDGKMIMHYISEHIENAGVHSGDATLVLPPQDLAPETVRRIVEATAKIGEALNVTGPYNIQFIAKNNEIKVIECNLRAARSFPFVSKVTNVDAIALATNAMLGFTFTPYPEISLPEKYVGVKVPQFSFSRLSGADPVLGVEMASTGEVACFGRDKYEAYIKALMATGMHMPKKNILFSIGSYKEKMEMLPAVQNLHRQGYNLFATSGTADFIQEHGIPVKYLEAITETDSQKSEYSLTQHLANNLIDLYINLPSKNRYRRPASYMSKGYQSRRMAVDYAVPLVTNVKCAKLLIEAIVRKPSLEVDSVDYKTSHRTFTLPGLINVQAYTDKVAEANSGSFEKATLAALEGGFTVAQVIPMGVENGKSLQAMHTNAVKSRCDYVLSVSATPDNVDGLDAFEEDVQSLYIPFNKLSGNVNKVATIASHFGSWPSGKPIVTDARSTDLASILLLASLHGRSIHVTNVSNRDDISLIALSKGRDLKVTCDVAVYSLFFSREDYPEATVLPTKKDQKALWDNLDKIDMFSVGTVPHELAVAVGQGANASAGMAESVSLLLSAVAEQKLTLEDVISRFHDAPKAIFDLPDQPNTYVEVEMDRASSFSASEGLWSPLNGKPVKGQVDRVVFYGKTVRLAGVNVSKSTGRDLTVAGPIRKQRNARTSFSQQTRPATQSITGIPSPTKNKDGLSSPVDGTQPRSFMSALDPLSTGKGDLTALKSHPAFKRRHILSVKQFTRDDLHVLFTLASELRTHVEKYGSADILKGRVLCSLFFEPSTRTSASFDAAMKRCGGTVVTIPVDRSSVAKGESLADTIRTLGCYADGVVMRHPVPGSVQTASKFSPVPIINAGDGTGEHPTQAFLDIYTIREELGTVNGLTITMVGDLKNGRTVHSLVKLLNLYNVHLNFVSPPSLNMPDSIKAECRKSGVTFHETARLDDVIGKSDVIYMTRVQQERFNSVHEFEAVKDAYILDNATMDKAKPSTIVLHPLPRLQEIDPNLDFDNRAAYFRQMRYGLFARMALLSLILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEZ5</accession>
    <name>I4YEZ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957207.1">
        <property type="nucleotide sequence ID" value="XM_006957145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEZ5"/>
    <dbReference type="STRING" id="671144.I4YEZ5"/>
    <dbReference type="GeneID" id="18472848"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56750"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019358_5_0_1"/>
    <dbReference type="InParanoid" id="I4YEZ5"/>
    <dbReference type="OMA" id="QMTPGHE"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF20">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="461" mass="51896" checksum="734F9B955BF87F73" modified="2012-09-05" version="1" fragment="single">MIVSTLANTLLYISQLFSGNILREDNDFGLSTSVVTHESPIYTDNHGRLSKWSADNKARFLSDLDKGKAGDWIIALGNEAADTDSLASSIAMAYHLEHTHGGSNAIALLLTPRDSLDLRPENQMALENAKMSHQNHQDLLTIDELPMKVKRLAPLLKGIVLVDHPKPVGDWKLANISGIIDHHKDRHWGLDANPRIIEMTKSCSSLVARELFSHMELYKKGQEIPKELADLLLAAIALDSSGLETATDVDIRSAAQLYKYTHGDKKFKGKKFFKYMSKLSKAYRDARNDLDKLDFLDLLKRDYKGDLFQPENHEQHRLHLGFASIPFSIGEQINRSLPNKTLAEYRAIERQFMVDRKSDINVILSKHKVKNENGEKVKIRDISVLVRHDGRLNGTDMAQTAFDNIVEAIEGNLQVQRWNGSDGGDDGGEPYGRRRIWKQIGSEGVGRKVVRPLVEDALMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFA4</accession>
    <name>I4YFA4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ubiquitin-conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957312.1">
        <property type="nucleotide sequence ID" value="XM_006957250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFA4"/>
    <dbReference type="FunCoup" id="I4YFA4">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFA4"/>
    <dbReference type="GeneID" id="18473596"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59867"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="InParanoid" id="I4YFA4"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000073">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="152" mass="17088" checksum="E9B1F581081DAC0C" modified="2012-09-05" version="1">MSAGLPKRILKEAERLQVDAPEGIQAIPSEEDIRYFDVSIQGPDGSPFEKGIFKLELWLPSSYPMEPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSSPNPDDPLANDVAEHYKTDEQAAKAVSKEWTALYAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFD6</accession>
    <name>I4YFD6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957343.1">
        <property type="nucleotide sequence ID" value="XM_006957281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFD6"/>
    <dbReference type="FunCoup" id="I4YFD6">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFD6"/>
    <dbReference type="GeneID" id="18473609"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59887"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="I4YFD6"/>
    <dbReference type="OMA" id="TMLFPLN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="15"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="36300" checksum="475C12E98F9773B5" modified="2012-09-05" version="1">MPAAGEKFYAYKGIGGKVVKSESTLGELKPDQVLIRITHGGLCFSDTHFMDSSFVLGHEPVGVLEAIGSEVKGFQLGDRVGYGCNHLSCDSCDECRSGYDTLCPERVMHGSPEEGHQGGFGKYVAMNARFAHKIPDNMKSEHAAVLQCAGATVFSPFLKYNISPISRVAIAGIGGLGHVALQVARAWGCHVTALSSSNRKRDEALAFGAHEFKNVTEEGWDKEKYDFIISTNNAQPQYDSYVNALAPRGTIVVLAVDFGRLEAPYAPLLLNESKIGGSLVATRYEHAKMLEFMGRHNITPTVEVLQLSEENLQLAFDRLKKGDVKYRFVLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV4</accession>
    <name>I4YFV4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956897.1">
        <property type="nucleotide sequence ID" value="XM_006956835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFV4"/>
    <dbReference type="GeneID" id="18473475"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59646"/>
    <dbReference type="HOGENOM" id="CLU_1225602_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFV4"/>
    <dbReference type="OrthoDB" id="3361769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="226" mass="25121" checksum="8F27F379E0E40466" modified="2012-09-05" version="1">MAGHSLNITLTVVLTVLAAISIILVTIYLIKYDAPPMLQTSIIVAPAEDEEFYVEDLDDTGGDIDSVRKSVAVNHRNTYNLRPLSTFKSNRESVYKSKPDLSNVRASWIEICNPKVPPKLNDKAKNLRGLPASPRPPSFFPLNIDPNSPGLPTSVRPIAVSPIVEEESSTTSQHDQRNSSYLTVFEDEEFAKKIIDRKSRVMSYAQYPPQQSRMSFVAGDDSKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ2</accession>
    <name>I4YFZ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3 7">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3 7"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956933.1">
        <property type="nucleotide sequence ID" value="XM_006956871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ2"/>
    <dbReference type="STRING" id="671144.I4YFZ2"/>
    <dbReference type="GeneID" id="18473486"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59667"/>
    <dbReference type="eggNOG" id="KOG1557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031243_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFZ2"/>
    <dbReference type="OMA" id="GDAMQKW"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="353" mass="38239" checksum="5EA68093E5B8DCB1" modified="2012-09-05" version="1">MSTQGYSFAKLSIKSDFNDELKHTAHALVQQGKGIYATDETTEAISARLAAAEGVEKNYSDDEQKQRRYEWRKCLYETLPTDYISGCILYQETLVDFNLAGVLADRGIIPGVRIDTDGQPLPGAGDGEVFTQGLDDLTSRCRLFKEKGARFTKWRAPILVNSSTLPTELAIDAQATSLARMAAVSQSTGLVPIVEPDLDFSGDASLERSLEVHTKVIAKIYEKLAAHGVYLEGTLLKPSFVQPGASTNERKNLTADAVGEATALALSRAVPSAMPGVVFLSGGLSDTDSIAFLSAANKYAKKEGIRLPPLTFSFGRGLQGDAMEKWTKKDFKGARQAFEKRAQECSKASLGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG13</accession>
    <name>I4YG13_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956953.1">
        <property type="nucleotide sequence ID" value="XM_006956891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG13"/>
    <dbReference type="STRING" id="671144.I4YG13"/>
    <dbReference type="GeneID" id="18473495"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59679"/>
    <dbReference type="eggNOG" id="KOG4704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577723_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG13"/>
    <dbReference type="OMA" id="NVINDDR"/>
    <dbReference type="OrthoDB" id="3153684at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53991" checksum="7D6EF26D89FFA54E" modified="2012-09-05" version="1">MVDSHKMELPPGVLGLFVTEFKPNVGNSIVWKYMNPSNDNDPDLYGIEYTSMPSGMHLMESDEIYFTTRDYNHGIAIYRKISSTEEQERGVKMFSVGLITSDTYVPYNYLPELEELSLYLMTNPPSDDLPVMFFAPIQSSDYSKIIQQSPSPKALAFLLDLLGPLLLLLFRFLLARKRVVVFFRPTEGRGVGWISTALDTLAKILNEVDDGVSNQTRTNIIGNIGLIDLDRLKDIEGGFVASTTDALLLEKPQVYDAIIDLSPKVKYPSLYISQKQGNEMLVKRQTYTLGDLYIWRQLRSRIDSQTLVSSPPYGLIDLIADIWSSLFGIKNSIHIPSPASSDYHEENEDEDEDDDEEVRLFGKALNPTPAITSFMKSYSNAILASLLTLTLKPDHDYNSNGNVRDDDHTHHNEGEEGEEDSPLELTASDLLSLGLSPLSDVDSIIAKSISKTELGRNVHISISCAWSVASFVRRQCLSIGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG15</accession>
    <name>I4YG15_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor, 25 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_16089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956855.1">
        <property type="nucleotide sequence ID" value="XM_006956793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG15"/>
    <dbReference type="STRING" id="671144.I4YG15"/>
    <dbReference type="GeneID" id="18470687"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16089"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068704_1_1_1"/>
    <dbReference type="InParanoid" id="I4YG15"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="23379" checksum="002D77F97D0CB8A7" modified="2012-09-05" version="1" fragment="single">SNTINIYPLQNYTFTQREAQPEEDASVAARLQRLQNNYEDFGMRRTVEGIMVVHEHGHPHILMLQIANAFFKLPGDYLTPGETDEPGLKKRLDDRLAPLDPTMFDPEDGALNEWEIGDCLAQWWRPNFETFMYPFIPAHVTKPKECKKMYVVGLPERKVFAVPRNMKLLAIPVFELYDNSGRYGPQLAAIPHLLSRYNFILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGF8</accession>
    <name>I4YGF8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957085.1">
        <property type="nucleotide sequence ID" value="XM_006957023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGF8"/>
    <dbReference type="STRING" id="671144.I4YGF8"/>
    <dbReference type="GeneID" id="18471354"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31684"/>
    <dbReference type="eggNOG" id="ENOG502S1CS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072613_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGF8"/>
    <dbReference type="OMA" id="TWDLWSY"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="200" mass="21341" checksum="B3B83F2FCAA95EEA" modified="2012-09-05" version="1">MSSSGSDSNTASDTGSSSSGSSSSQTTSVPATAGVGGLTFTEPPQTKTSYYKVAEGNEITFGWSLTSIYNTPESLTFDAVNTDSGNTYTMGSVAGGDTTFKWDPYKHFTDGNDPPLVYSTYQVRVYDDNGPSAAAKPGGFMPNSNLRFALYKPEKYTPLDEWVCPNCSSAVRNIPIASLAWLVTITLMLLSGYSLARSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGG6</accession>
    <name>I4YGG6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_36381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957092.1">
        <property type="nucleotide sequence ID" value="XM_006957030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGG6"/>
    <dbReference type="STRING" id="671144.I4YGG6"/>
    <dbReference type="GeneID" id="18471959"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36381"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="InParanoid" id="I4YGG6"/>
    <dbReference type="OMA" id="CNHESHI"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="304" mass="32835" checksum="9A4721B7221D84EA" modified="2012-09-05" version="1">MLRKTFVRLSHENPFGLPKKKPAPLTKRAIPHVKHTIVVASGKGGVGKSSIATNIALSLSRLPSSPRVGLLDLDIFGPSTPKLLGLDREGMEAELTDYGALKPLSNHGISSMSIGYLLPNGPKAQDTPVVWRGMMVQKATQQLLFDTDWRGVNERQLDYLIIDMPPGTGDVPLTVGQLVQSSGAVIVTSPQDVALLDTRKGMATFTKLNIKILGMMLNMSHFLCENCSHPHEIFGDVKNYDRALKELNVDDLGRLPLAKEVSSGGDSGLPLMAMSDKVSLSNGASEARKIFTQTAQALFSKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGT0</accession>
    <name>I4YGT0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_15227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956497.1">
        <property type="nucleotide sequence ID" value="XM_006956435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGT0"/>
    <dbReference type="FunCoup" id="I4YGT0">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGT0"/>
    <dbReference type="GeneID" id="18470652"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15227"/>
    <dbReference type="eggNOG" id="KOG2691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGT0"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="112" mass="13136" checksum="2346DDE139D14019" modified="2012-09-05" version="1">MSLKFCQNCNNLLYPREDRERRTLLFACRNCNFEESAVEARVYRNDLMRQSKEEAGVTQDLGKDPTLPRTNIECPKCLSSQSVFFQDQSKRTETRMTLFYVCISCNHAFSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG7</accession>
    <name>I4YHG7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_35907</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956786.1">
        <property type="nucleotide sequence ID" value="XM_006956724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHG7"/>
    <dbReference type="FunCoup" id="I4YHG7">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHG7"/>
    <dbReference type="GeneID" id="18471934"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35907"/>
    <dbReference type="eggNOG" id="KOG0826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031067_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHG7"/>
    <dbReference type="OMA" id="QHYLARC"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="18">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="355" mass="41447" checksum="088EB485432B1EEB" modified="2012-09-05" version="1">MDYQLQSSYTERPSLFELFAQDELTDLLQPAVKYVLSILATRYPRYLLRLVNKHEEFYALIMLIVESHYLRTQNASFTESFYGLKRRNRPAFEPTHSSPYLDKHHQAFDKLTKGQIYGSLVFLVGVPYLRTKSKELYDIWGGNTSGELFRDSEHSQQEVWSTYKRTFKKVYPYANLALESILLSYNLRYMFNSTPFYRPWLQWMNIDIRRATLADLVCLISSKSSNNKSLLRKIPSYLLSSLKTALPVTLFILKFLQWWYSSQSPRLQHEEAKKANDSRTPPPAKLTKHPESAVKDAHIRYGIDPLTGEPLENATLTPTGYVYSFKSLFDYVEKHNRCPVTLKPVKVTQLRKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG8</accession>
    <name>I4YHG8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_35908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956787.1">
        <property type="nucleotide sequence ID" value="XM_006956725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHG8"/>
    <dbReference type="FunCoup" id="I4YHG8">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHG8"/>
    <dbReference type="GeneID" id="18471935"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35908"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_3_1_1"/>
    <dbReference type="InParanoid" id="I4YHG8"/>
    <dbReference type="OMA" id="INYICQL"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="514"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="801"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="858" mass="95439" checksum="D4B4EA111BB285DC" modified="2012-09-05" version="1">MKYQLNVISTPASDTEQSLCLFFPNARYLFGIPEATTRMCIQRKQALKKLRAAFLSRSTDGGLAGLTMSYADSTGQGTLNVGGPEGTLHRVSGMRYYNKRDHLKVNVLESLIGDRNEDALYSDEFVDVYAVTTNEAREARSRTPSSSGSDSPSTSPRRNSLSFEESLKYKTSIINEIFPGLPLNPDQDAMKLGGDAIEDIPSGNDAKLSRRLARLPAPRYTRLDTAASYVVMGKPMRGKFNNEIANQLQVPGPLRSKLTKKESVSYKTKDGTDVTVSPEQVMAPDTDPTVFFVLNVPNLNHVDSLVNSQTWKRHMQTNKPHIIVHNIGWGVLENEKYVDWLKSWGTATHHLISSPEYTPNNISLPSSFLSVKRASHLSEVFKTPLYSLDAPRKLPESLTSEVNIEILDKHHLAELNPPQAPAIEPTLMSGLPPGFDIHEDTSEEDLLKQGLTDKSWENYSKACEAIKKEVAGLTPPEEQPGDDVVVTTLGTGSALPSKYRNVSSTLLQTPYGHILLDAGEGTWGQLSRRFGDRSRQTLPRDGEEDAWDVLRNTKVIYLSHVHADHHIGLAKLLLLRAKAVKQDNPVTIICNHLIRTYLLEQNELEYLGIGKKVKFVDTEALLYNKDTNVDLTGWKKLQMEEATTNLNSLRQTLNLKDVKTALVKHRCKCHGGIFESNDGWKVVYSGDTMPCDSLVEAGKDATLLIHEATMEDGLEETAKAKGHSTIGQAIDIGKSMSAKKILLTHFSQRYSKLAHSSESEKGTHIIAHAFDLLSLRVGDMWKMSHYNSPLSFLLAQEAAGDESEDATEEQAEDNNSGKKANKKSNKKQNKEKRKLDSPNSKESNKINQQRQKKNKVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG9</accession>
    <name>I4YHG9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_27489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956788.1">
        <property type="nucleotide sequence ID" value="XM_006956726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHG9"/>
    <dbReference type="STRING" id="671144.I4YHG9"/>
    <dbReference type="GeneID" id="18470995"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27489"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_1_1_1"/>
    <dbReference type="InParanoid" id="I4YHG9"/>
    <dbReference type="OMA" id="DEPYEWH"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000109">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="30523" checksum="2A9F21663EA75BBD" modified="2012-09-05" version="1">MASPAARKRLMKELATMQLEGCPPYTYARPEESNILIWHFVFLGNEDTPYQGGEYHGVLEFPKDYPFSPPHIKFHTPSGRFKPNTSICTSFSDFHKDTWNPMLSVSTILTSLLSFFNEDAVGTGGMTTSDEERRRLARESKAFNRDRSRNVKFSKVFDELLHPTDGQKSLDEVLADSIKQKVVIPKKPTDDDNTKTKTEPSSKSNPDTKGVEKSLNNLTIKDNADPKTKESSSNIDSSNKLATSDTPATGVKPPAKKGSAMSRFRAKVKNNATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI0</accession>
    <name>I4YHI0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956798.1">
        <property type="nucleotide sequence ID" value="XM_006956736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI0"/>
    <dbReference type="GeneID" id="18475281"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67675"/>
    <dbReference type="HOGENOM" id="CLU_984193_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHI0"/>
    <dbReference type="OMA" id="RSACSQQ"/>
    <dbReference type="OrthoDB" id="3364608at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="32100" checksum="E73C5A005F159D92" modified="2012-09-05" version="1">MIPPNRLSPKPKQSLPKRPLSSPKLFRLNKKSRLSLHDELEQEDTRSFNLASSDDDLPASAYFHKGKKRVGYGLFDDEDISEDKHDYDHSINQPSTSTSKYANSIPQEDDSDNIFNARSTHRPKRGLRRLQSSSPEPEHLTYSFRGAKCAFPNPYKDIPPSVKRLSKLDPSHVDFLPTPNPKPKLLFADAHRESQAKAQAADEKAAKEKRKSMIEQPENDDELEEYQLDDTETVTSKKRSATSQQPPVTPRPHKLLNPTHTDLLASAKKSNRRAPQFGNSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHM8</accession>
    <name>I4YHM8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956150.1">
        <property type="nucleotide sequence ID" value="XM_006956088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHM8"/>
    <dbReference type="GeneID" id="18473226"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59209"/>
    <dbReference type="eggNOG" id="ENOG502SQX0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144964_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHM8"/>
    <dbReference type="OMA" id="CIEGLNA"/>
    <dbReference type="OrthoDB" id="2863306at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698179" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="132" mass="13956" checksum="3C7F3F868E24FAB3" modified="2012-09-05" version="1">MVKVTSIILASGALFHSAVATTYAQFCNDNNCEEGCGGSVSVDNSACLVENGRGSVKFHDTNFGSVSLIATNNDQCSCQAFCYPHVVKALATSNDCLDLKDPLHNFKSFRFVNVDLAGGCSTDENTCDGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHZ3</accession>
    <name>I4YHZ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_62254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956258.1">
        <property type="nucleotide sequence ID" value="XM_006956196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHZ3"/>
    <dbReference type="STRING" id="671144.I4YHZ3"/>
    <dbReference type="GeneID" id="18474729"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62254"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHZ3"/>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="281" mass="30657" checksum="08A49DAE5EC4B44B" modified="2012-09-05" version="1">MSNFEKLSSNKVNGGWLDKYKFKSDSLGGLDTQINVYLPPNAKNAPVLYYLSGLTCTEDNAAQKGAFFEEAAKQGIALVFPDTSPRGAGAPGEDDSYDFGTGAGFYVDATTPEFSKHYNMYTYITKELPGKLKLSGLPLNVDNASISGHSMGGHGAITIYLREFGKYKSASGFSAILNPTACPWGEKAFNGYFGSLDAGKEHDATHLIKQAQGKDPKILLVQGSGDNFYKQGQLLPENFVSAAKEAGINVDYRLEDGYDHSYYFISTFAPEHVRFHAKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHZ9</accession>
    <name>I4YHZ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956264.1">
        <property type="nucleotide sequence ID" value="XM_006956202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHZ9"/>
    <dbReference type="FunCoup" id="I4YHZ9">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHZ9"/>
    <dbReference type="GeneID" id="18471247"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31093"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030206_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHZ9"/>
    <dbReference type="OMA" id="CQIFFER"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="454" mass="50395" checksum="F45D7120A5091705" modified="2012-09-05" version="1">MLAGKPLGEIFHKPQLYFEAKVGIKRTTLESISKGEMDDNMDVDERKPMRLRPSSYLVGQQLEDAIQAGEDLEISYPWKFGRIRDWVGAEALWKHALKQLLGNPRAATALVLVTVPHGLSKDENERITQIFFERFNVPVFALVERPVLGLYASGSVTGLFIDVGHDSTDIVPVLDTIPQYTAATQWKFGLRELSIYLAGLLKNDTHLLGHEKLSGLSEDERFDALVEISQELFKHPESLSLLPEEEEKDKKKKGEEFDIAAALVNGQEKNLIDEKNAKENNAAAAQGRFQLEWRGSTISIGKIRQRFWEPLFNIDLLKGLKGIEEEQTLVGLPEAILSTVEQCEIETRSQIYNGLVLAGPLAGAKGFTQLLAPHIGPYLSKGENNELQPSASILKVLRVPDYFADFKGRDDLNTFLGAGIVAKITSADHSSFAITKADYNTRGPAVITVAPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI36</accession>
    <name>I4YI36_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956298.1">
        <property type="nucleotide sequence ID" value="XM_006956236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI36"/>
    <dbReference type="FunCoup" id="I4YI36">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI36"/>
    <dbReference type="GeneID" id="18471253"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31120"/>
    <dbReference type="eggNOG" id="ENOG502QUN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_3_1_1"/>
    <dbReference type="InParanoid" id="I4YI36"/>
    <dbReference type="OMA" id="MIAYNGA"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="346" mass="38329" checksum="4B968DAAF5FAA947" modified="2012-09-05" version="1">MISSKPQQGQAESRFRRPSVNNLEKSLAEILKDQQASKESGERRVKPLPKPEDIKLILSDVDGTLLDDDHDVHPRTSEGIRYIRKNFPHIPFIPITGKQRVSCEHVAKCCGLEDMPSGCCHGSIIYNNEGKLESQVGIKPEVVVKVTEELIKENKSVFIYEHDSVHCVALEEHPSLNFYEITRGYDPSISDKRGTDYLERVAKGEVVVTKMFLPMEVSVVPGQMDHLNSIFKNGEDYRMTRALKDIIELIPAGIDKSVALAHFAKVYNVDPINIMTFGDGENDVGMFRASGMSVSMGNAMPMPAQNSDFSTVTNNEGGVGRFLDACFRPTYNPENSGTDSGYASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI55</accession>
    <name>I4YI55_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956315.1">
        <property type="nucleotide sequence ID" value="XM_006956253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI55"/>
    <dbReference type="FunCoup" id="I4YI55">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI55"/>
    <dbReference type="GeneID" id="18472782"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56198"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003043_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI55"/>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="2">
        <location>
            <begin position="279"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116811" checksum="CE96C124B44EDD1E" modified="2012-09-05" version="1">MEEDELLSTFNHLQEYSKYLDIVLDKGITDTRTKDSAVYQIGLVLEIYQEQSYLLDPYLDQMLSPVISALSTSISRNEQLSTRNTLSKLIYTFSKTRGHKIITRFFPHSIPDLILVLDASRSFTEGVAWEYRYILLLWLSIAIKIPFDLSKLFPNQDIATQLQNICTAYFHHPGKEREAAVLVLSRSFMRQDMKSRLIGFVQWCLAQLETAKENAFIAPSVLQFFSEVLKVSQGATVAELQGPIEHSLAHSADISLNNPLLRKYCVKLTARLAYKLSDDIDKVEETIGYLLEYLSDTDTIVRWSAAKHLSRIAAKLGDEHRTEILDAVLSIYAENTNVDDASSNEFANCDYSYVSESAWHGATLSLAEAFRNGVVPSDYVSKLVPAAIASIHFDLKKGTASVGSNTRDAAAYLFWAMSRSVSPAIMEDFIDKISIHLIQKALFDREVHIRRAASAAYQEMVGRTNLIKHGIDVLRAVDFFVVGVRRTAFLDAAVDVCEYEFYRNSIIPFVVKSVITHWDFDVRKLASQFLGRVCKNHPYLLDRVVEELKPRLASGDPVILHGTLSTLHQLSIAFMNNNQLYEKIFEQLEHIQLWQFHTPRFSPVLEVSNNLIAAIASTCNLESRKEIALKIIDIGLKHKSDVVRYSSANALGCLSKTTDCKSFVQSMIDDFQSSEGFFQQSIALSLGYLYYNEVTLLNVSLNCLLSIVSSKTVVECRLNAYESLSKLYTSCTSQQHTILQTLYNGLWDYSMDQRGDVGAWIRQSCAKGLTICLSENVEPSFVDKVVSRLVGISLDNIYTSRWVAIEELENMIDKKLINDTQTTNSLRDFFYNTRKDTEDVYSSSKIFEHVVTLYQQESKLRDDILMGLGLALISKNEISVYNSRMAILGLADNLLDDVVKRSIMLSESNTKTSFFTGLANTLFVVLDERDVCCDDLSEIVAFNSKYCQKSKVINRITIGMKIVATLFYKYDYQAAKKSLIQYLTHSLPRIRAITAEEVYIQSQVYDGDQGLLDWLMDIDWLGKNLPAAEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI65</accession>
    <name>I4YI65_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_31136</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956325.1">
        <property type="nucleotide sequence ID" value="XM_006956263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI65"/>
    <dbReference type="FunCoup" id="I4YI65">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI65"/>
    <dbReference type="GeneID" id="18471256"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31136"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI65"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="465"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM23657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="762" mass="86413" checksum="5A1A33F9E108F0F2" modified="2012-09-05" version="1">MAYQRGKNKSTAGEDLQTYTSSSTFAYQSISDDVKANQPVNEKKTSPIVSTTGKRDWLIGLLLALIALAIRFYRIEHPDEVVFDEVHFGKYAGYYIKREYYFDVHPPFAKMLNGLAGYLSGFNGDFRFSNINDSYTAGGVPYVGMRSLSAILGSFTIPLIYGIMRESGYPETIGILSATIMLFDNGHVAQTRLILLDAALVFFMALSLYCYIRFSKCRKSPFSMSWWFWQALTGVSLALTLGCKMVGLFTFLTIGMAVAVDLWKILDVRRGYTMNQVTRHVAARAFCLIVIPAAVYLATFWVHFKILKYSGPGDTFMSPRFQETLQGNPVLEHSRNIYYYDSITLKNRDSSNFLNSNFNYYPLRYPDGRVSSQGQVVAGVPHRVKDNYWQILPAEGSVRKDNLKVRNGDIVKLFHQQTSTTLLAHDVASPLTSTNEEFTTWPLNSTHRRPREEEFQIHVLGAEEGDEIRSLASHFKLVHVDTGVSMYMSGKALPSTWAPGQFEVNGKKDQSEQGASWFIDEFNPHPDMKVERKGVTDNKQVKTMNFFKKFFELQLLMLKHNAGLTNPHPYASTPIEWPFQLKGISFWTDNDKQEQIYMIGNVFGAWLSIAAISIFAGIWGADQLSRRRGQEPIEDHVRHRMHYSIGFFVSAWAFHYLPFFLMGRQLFIHHYLPAQLASALVAGAVVNFIATESADWPLTGPYLRTRIQFPREGKIVVALLISALVAAFWFLSPLTYGTPGLEGSQVLQRKLLDSWTLHFSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI77</accession>
    <name>I4YI77_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_62336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956335.1">
        <property type="nucleotide sequence ID" value="XM_006956273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI77"/>
    <dbReference type="STRING" id="671144.I4YI77"/>
    <dbReference type="GeneID" id="18474738"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62336"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724027_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI77"/>
    <dbReference type="OMA" id="DNITSCA"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="382" mass="43075" checksum="2C9BFE58AF6C5464" modified="2012-09-05" version="1">MFYDDDISSIWKNDNKLKSFTVPKQSPQSDIAFVSLQNSNHAVLHNSNMLTLKNSHNNNINFRELLKPQSKVNYSELVSRIIVKTDQQASIFLQQKLKSLNKSDINLLVDAVIQRAFPLITNRFGNFLVQRVIDLDDVSYKLRIVNSITCQVESIAMNSYGTHVLQKLLSTSPEHVKILLVNELLNGNIAQGIVHKNASHVWSKVLETQWFIYSPSIMIAVNAAMKYRWVECANTDTGSLIIQSILSKEFSEVCFNEITTCALNKWGSTVVQYIVEKASNMSLARVTCLLIYSYKQLSVNFYGARCLMACLTIGDKKDYAINLLSDLLFNDPDRIDTLANLMASSIGVQFLVNILSLMSNEKYHQLLTLIHAVKKQNAGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YII9</accession>
    <name>I4YII9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956444.1">
        <property type="nucleotide sequence ID" value="XM_006956382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YII9"/>
    <dbReference type="GeneID" id="18473336"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59408"/>
    <dbReference type="HOGENOM" id="CLU_912778_0_0_1"/>
    <dbReference type="InParanoid" id="I4YII9"/>
    <dbReference type="OrthoDB" id="10475111at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="305" mass="36004" checksum="E770E37681ABE321" modified="2012-09-05" version="1">MILTIKFLYLAVSSYRSIPLVLRQSSMQYPNYLQLYQQLCSIPQEILIEVMEFAPLLATLNRSFYSIGRSTLMRSLRDPFLTIGTIPAIEPEDDYSSLYLTKFANEPSKATYVENLTLSALSSNDFRHLNNFTNLKKLQMIVHWITLNQILHNVQIDSVKHVTIQFGSLKVLLYSLRRYALHTSFPNIETLCLHVNIGFNETSKDLERYLDSNHGLSKLKAVVLLEMDVSNRKFGFFDYRKQLEKVHIYTHTDELFVKISEEYEKLQLLRHIYRWDNTKRSFWEYFFGKSNRWPNGMKRELLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ12</accession>
    <name>I4YJ12_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_14312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955668.1">
        <property type="nucleotide sequence ID" value="XM_006955606.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YJ12">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ12"/>
    <dbReference type="GeneID" id="18470632"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14312"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJ12"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="832"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="884"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="984"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1604" mass="175382" checksum="8AC0466A4E271C77" modified="2012-09-05" version="1">MIALQELAEVLAVSTEETLAGSFQVEAFSKELIAIMNGDPPTTADPSKKKEPLSAEAQEEAEIMAALAASGGDGFGDNVGEAQLLACRCLANLMEALPGSSIRVAQNGAIPILCSKLRDVQYVDLAEEAVSTLGKVAQEVPNKIVSEGGLTAILQYLDFFNSHVQRTALTAAANCCRALTPESFDMVYDAISKIRDVLGYSDQRLVEQACLCVVRIIDSYKNKPDLIEKLLEDGTLITGVVNLLSPSGSGGTPLITINTFTALLRAMSSASKASAKASIALLNRNIVDTLYNILTGVLVPEKTDPTTQAMEDGSAPGEGGLADMVVLENLAHRPKDQVDEALSLSLELLPPIVPVGVFDNKSYINKTEGQTEDESSQNAENKEKPESIITSRSKQREAARQESMRIRIECLRQNPDSINRFMSLMVPVFVEVYAASVSTPVRSKALAGLLKVISFAEEKQLHDLLRYIPMASFIGGILSSRENPNLVTGALQLVELLLNKLPGVYHSALRRQGVMYEIEVIATDKLNSEKDEKEKPNEPTSPLDKDEGPLGDPVSNLARALRVDLPPSEAPSGFLNLGSTGPASRLATYLAAASNVDPSDAAIARARTLKVIFSKLEEQNGADTYDDAKVALAEIRDMVDKLKSSETSTVQIKETLQKLGNWFVREDSMSSFELLRSGLIEGLLEFITGDTESLPSSMRHKVVLETFTNTRSHIPGSPSALLSLVKRLQESLSRLEPFNVGTVGSALGDDSRRNPMSALGRQVRLRLVTDDQELSKVQPTMVVSVHAIATFQVLNDYLRPRIMSALSGKGGHGSSRLSGVLAAFAAAAGIPAPEEGSTAASSTKKDKGKDSKGGSRRNSKESLTNTPAANDENKSKGKGKESVQGDEDDTDDHSQNDIDEDELRAMEEDEEHDEHDDNEDDEHDPFAEMMGEGRLGHEKTINLDVKDDGKEIEAKTPDGTRIQTPSNTNDASPTARKSSKSGSKKPESLDNKGKELKPKGSYASALKTKPTDFHIEFELDGQKVDLESTIYSALHRKESNSLRNPFVNVYTLKFKHIDGPAEKKEKIVAKPNISAVTTENVKDAWSELPESIAKDSQHAPILQLLRVLHALCADRQELNAISHPNAALAQDTGVGEMTFVNNKLTAKLNRQLEEPMLIASSCLPEWAIDLPTAFPFLFTFQTRYAFLQAQTWGTTRLINKWQNEASRIGSDNRRPDPTTTHLGRMQRQKVRISREYVLESAIKVFELYGGSSSILEIEYFEEVGTGLGPTLEFYSLVSKEFARKSLRMWRGSQDSSESPYVFSPTGLFPEPMSDKESESDKGKERIKLFRILGQFLAKGLLDSRIIDISFNPLFMKLVLGLSIPKSVAGVKLVDPFVGKSMMEVQKIVDSKLSTSEITEKVSALALDFTLPGKPEYELVENGTNVDVTIDNVGEYLDKIIEATLGSGVSKQVEAFVEGFSKILRIEDMKIFTAEELTSLFGNADEDWTNETLSEIIKADHGFNNDSPALRRLVEVMSEFDNVSRRDFLQFLTGSPKLPIGGFRGLHPQLTVVRKSPEAGYKADDSLPSVMTCANYLKLPDYSNKDILKQKLTIAMSEGKGFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ35</accession>
    <name>I4YJ35_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59039</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955812.1">
        <property type="nucleotide sequence ID" value="XM_006955750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ35"/>
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        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ35"/>
    <dbReference type="GeneID" id="18473140"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59039"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="InParanoid" id="I4YJ35"/>
    <dbReference type="OMA" id="HETTWGI"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
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        <property type="entry name" value="EF_hand_assoc_2"/>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="Miro"/>
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        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="19">
        <location>
            <begin position="412"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="635" mass="71155" checksum="3AA775954C23F355" modified="2012-09-05" version="1">MKEIRCVLCGDQGVGKSTIITNLIKNQFIESIQPCLPEVVIELDYNLHIIDTNEDNLLREIKKSNVICLVYSISDSQTHSNIREWLSYFKSNGINNPIILIGNKLDSPNPDYSFDTDIIPIMKEFKEIETCVEASAKTKTNINEIFYFAQRAVLHPTAPLYDSRQHTLKPASASALSRIFRLCDTNKDNLLDSTELNRFQLKCFGTPLKQSELDAIMELVSQHSNQTVSKVSNGTLALTELGFILLHTIFIQRGRLETTWTVLRKFGYAQDLRLKEEFLYPKFDVNADSSVELSPDGYSFFTEIFEKFDIDKDGALSENELSDLFLTSPGNPWMNKGFPDTTLTDEKGAVTLQGWLAQWSMTTLLDHKTTLAYLAYLGYEPSSNAPVQDSTSALKTTPPRRRRKGEVGKVQRNVFLAYVLGAPGSGKTSLLRSLLNKQFNGTHTSTNGVLSVVNSVEVEGGAEKYLVCQEFEATTLKNSKKLQLADVIVLVYDCSDANSFSYLSNLHQNYNLDGIPSVYVATKSDLDLAQQRHEVQPDVYCRRLNLPVPIAVSIKTNQTAGIFQTLCSVASNPRQALPLSGRSSSRSMLHLLSLTLTVGGGLVGIAAILTKYNWRPWSMYMHNVYRGMLAWWNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ76</accession>
    <name>I4YJ76_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_30793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955851.1">
        <property type="nucleotide sequence ID" value="XM_006955789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ76"/>
    <dbReference type="FunCoup" id="I4YJ76">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ76"/>
    <dbReference type="GeneID" id="18471184"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30793"/>
    <dbReference type="eggNOG" id="KOG0856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="InParanoid" id="I4YJ76"/>
    <dbReference type="OMA" id="YDETTDW"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="15090" checksum="BD35EA7E7BBFB4C7" modified="2012-09-05" version="1">MVSESEWQAKLSPEQFRVLRQKGTERAFTGEYDNHFDKGVYTCAGCNTPLYKSEHKMVSHCGWPAYFTALPGKINRHVDNSFGMKRIEITCANCDGHLGHVFEGEGYKNMAGEKVNDRHCVNSVSLKFLPEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA6</accession>
    <name>I4YJA6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_55915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955878.1">
        <property type="nucleotide sequence ID" value="XM_006955816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA6"/>
    <dbReference type="FunCoup" id="I4YJA6">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJA6"/>
    <dbReference type="GeneID" id="18472754"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55915"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="InParanoid" id="I4YJA6"/>
    <dbReference type="OMA" id="HDEEIGC"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697852" evidence="6">
        <location>
            <begin position="18"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="378" mass="41833" checksum="244AC8E4CF240666" modified="2012-09-05" version="1">MLKFVSTLAVAIGVALANKELFSLHKDLIIRPSITRNETLAVDFLIELQDVINPNVDRSIRRQNLFAYLDNPEDVKILLNSHIDVLPPYFEYKEAVDDQGRELIYGRGANDAKGQIAAQIIAVEELRKKNQEIVKKVGFLYDLGEEGLYDGATSAQEILPQNLEYVIAGEPTELFQISSHKGNMGFEIRAKGLAAHSSSPHWGVNAIEKLSEAILKLESVALPQDKILGDTTTAVTKIKGGTAVNKVPDEATAYVNVRTSVPSEETWKALKESGLESEWIDLILVDDSHDPVTLDTIENWRPSQTMPVGTDLFAWKQPTVKKILIGCGSSGSAHKLDEHIYKQELLDGVDMYVELVEGLLTGKLKVAGEHTKHEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE4</accession>
    <name>I4YJE4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_49757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955912.1">
        <property type="nucleotide sequence ID" value="XM_006955850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJE4"/>
    <dbReference type="STRING" id="671144.I4YJE4"/>
    <dbReference type="GeneID" id="18472506"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49757"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJE4"/>
    <dbReference type="OMA" id="CCGDIKK"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="452" mass="50088" checksum="69139DCC199DE590" modified="2012-09-05" version="1">MDMAIMPLAVLLYLMAYLDRGLLGLPTITKLIHIETVLDGEEDKYSLLSSIFYISYLVMQVPLTLLAKFMKRPDIMIGFVAIVWGISSTLQATEYNYAGALACRFFLGFSEAGFGPLMPFYFSLFYVKNEMGFRTTVFIAAAPIAGAFSGIIAYGIEHIHSYIASWRILFLVEGLPSIVLGILVILILPSRIENTKWFNEEERAKALARKNTEMTQEKIGYVNWRHVLSGFTDFRTYLNCAIYMAINIALSSISNFLPQILTDLGYHGADAQLYSVPPYVCAGGWMIILSIFSDRYEMRGPFISVNLLISGVGYAMLLGLPTVGENALKARYGGIFLAVMGTYTAIPLTLSWSAANAGSESKKAVAIAMLNTIGHTLSVLGGYIYPDSEGPAYTRGYAICMAFAFWGSFLAATHTFILWQINKKRDKKEGVVEHTPDTFADADKAVGFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJH6</accession>
    <name>I4YJH6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_42280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955944.1">
        <property type="nucleotide sequence ID" value="XM_006955882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJH6"/>
    <dbReference type="FunCoup" id="I4YJH6">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJH6"/>
    <dbReference type="GeneID" id="18472245"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42280"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_7_3_1"/>
    <dbReference type="InParanoid" id="I4YJH6"/>
    <dbReference type="OMA" id="WKPITFA"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="45"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="216" mass="23780" checksum="37E8A4EF272BA8F1" modified="2012-09-05" version="1">MSDGQRTVAGIIALNSVIFFAWQVPNPVLRSFMKRHFLHAHDTPLHTMLTSVFSHRSIAHLGFNMLALYSFGPLSFKFLEKQETELEGTSVYKWLALYLSAGLLSNLASTAATKYTQRTLMPSLGASGAVYSTLVMSAYSNPDIKVNLIFFPWFGFPISTGVLAMVGFDIVGLLRGWKLLDHAAHLGGAGFGVFGSLYFNDMFRRTRGVLGYNAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJI3</accession>
    <name>I4YJI3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_30855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955951.1">
        <property type="nucleotide sequence ID" value="XM_006955889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJI3"/>
    <dbReference type="FunCoup" id="I4YJI3">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJI3"/>
    <dbReference type="GeneID" id="18471198"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30855"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_2_1"/>
    <dbReference type="InParanoid" id="I4YJI3"/>
    <dbReference type="OMA" id="RSNPMGS"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="74"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="456" mass="51812" checksum="05D19491A727C6FA" modified="2012-09-05" version="1">MSNTSENSPIERENADAQSVAGSNTSPAQAIPPTAPLNVNKEAQQVSNVVRKKLSGFVGFANLPNQVHRKSVRKGFSFTCMVVGESGLGKSTLVNTLFETSLYQPKTLPELGSESASTVGIENISADIEENGVRLKLTVVDTPGFGDFVNNDSSWDPIVTSIESRFDQFLEQENRVNRAKLNDNRVNACIYFIQPTGHSLRQVDIEFMRRLHTKVNLIPVIAKSDTLSEEEVESFKRRILSDIEHHNIQIFKSPVYEQEDEETIQENQEIESKIPFAIVGSTQTIQTPDGRNVRGRSYPWGVVEVDNEEHCDFVKLRQMIIRTHMEELKESTNVLYENYRSEKLLAMGVQQDASVFKEVNPTAKAVEEKALHDAKLSKMEAEMKLVFQQKVQEKEAKLRQSEEELYARHREMKESLEKQRQELEDKRRRLESGRPLTPERGATQSTQKKSRGFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJJ0</accession>
    <name>I4YJJ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_11682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955643.1">
        <property type="nucleotide sequence ID" value="XM_006955581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJJ0"/>
    <dbReference type="STRING" id="671144.I4YJJ0"/>
    <dbReference type="GeneID" id="18470593"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_11682"/>
    <dbReference type="eggNOG" id="KOG1265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846122_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJJ0"/>
    <dbReference type="OMA" id="KVHICES"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="3">
        <location>
            <begin position="187"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="329" mass="36818" checksum="43F176073446F192" modified="2012-09-05" version="1" fragment="single">DESKHLSEYFISSSHNTYLAKGQLYGQSTAEQYKNVLDAGARCVEIDLWDGDNDEPKVTHGWTLTSNLSLRDACQAINECIHSDDFPVIISLENHASIPQQDKAVDILKESFGDKLVSTPLEGVEVPTLAQLKGKVVVKVEYYPDSLQSLQEQVEHLQIESGSDDDEETKKLRQEKEKVRPKMSSSLSALGVIAMSVKPGNREWWNARSRITEPRNAVINVGESAMSKVCNDTRALADVRHTTKTQLVRVYPHGLRIDSRNLDPLPLWRGGAQIVALNFQVFDKGLQLNKALFANRGFILKPKHVRMGETDADTRMRKLNIRVVGASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJY2</accession>
    <name>I4YJY2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_67103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956089.1">
        <property type="nucleotide sequence ID" value="XM_006956027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJY2"/>
    <dbReference type="FunCoup" id="I4YJY2">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJY2"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GeneID" id="18475210"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67103"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJY2"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM24274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="20277" checksum="8A942427572D0627" modified="2012-09-05" version="1">MLSQEFKTLKNLGFRHCLLQALSFASVICTALSVYKGLGVVLNTESPIVVVLSESMEPAFARGDILFLYHPPYSTPIKTGEITVYKIPNSEIPIVHRVIDHHISTDGDYNTELILTKGDNNPGDDTVLYKGKKWLKRDQIVGKVMGYIPYAGYITILMNDHPNLKYAGMAIMALFVMLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y529</accession>
    <name>I4Y529_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668262">
        <property type="protein sequence ID" value="EIM19071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960878.1">
        <property type="nucleotide sequence ID" value="XM_006960816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y529"/>
    <dbReference type="GeneID" id="18471853"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34294"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y529"/>
    <dbReference type="OMA" id="FEEWICT"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="23613" checksum="3E1ECA950A60BD27" modified="2012-09-05" version="1">MKGREGTIVQLNWIPGHVGIYGNELADRTANEGRAKCNHYTNIDFTLRTSYSAMRRRMRERYTAPLKIEASKLSVLKSNTSKISAGKLTAAKTAKILNELPRATRCLATQLRTGHFPTTKSYRYRFKLIDSPKCRTCGVDDNISDRVFICRRHMMTRMTLRRKITKINVRFELGPMLRNAQALQALYEFFKPQLTTYPRDSDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5A9</accession>
    <name>I4Y5A9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SKN1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_49459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960813.1">
        <property type="nucleotide sequence ID" value="XM_006960751.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5A9"/>
    <dbReference type="FunCoup" id="I4Y5A9">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="GeneID" id="18472497"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49459"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y5A9"/>
    <dbReference type="OMA" id="GYIHWIN"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GH16" evidence="9">
        <location>
            <begin position="60"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="505" mass="56370" checksum="9BE2A8C489EAC790" modified="2012-09-05" version="1" fragment="single">MRFYYRWCSINVIVSLLRLQKHILRYKSAGYPLLEAFRKRDTDTGGSYGLGGINATGQIPEYSINFGMIDPDTPESVHHRTGFDGKKQVLVFSDEFNVDGRTFYPGEDPYWEAVDLHYWGTNNLEWYSPQQVTTTEGKLAITLDERETHDLDFAGGMITTWNKFCFSDNAYLSASIALPGTSDVWGLWPAFWTMGNLGRAAYGASLEGLWPYSYDSCDVGTVANQTYQGQPTAVANHEVGSEYDEGALSYLPGQRLSRCTCPGEVHPGPIDSKTGEFVGRAAPEIDVFEAQVEIASRTGQVSQSAQWAPFNANYQFIDQKGKTYEFHNDEAEINSYLGGVFQQATSSLATTNQACYSGTNPTPNGSCYSEYGIEFESGNNGHITWASDGEETWTIFGSAMGPDPVAKIGQRTISEEPMYIILNLGISKNFGDVNFDELVFPAIMYVDWVRVYQPEGSINLGCDPKNRPTSNYIEHFKEAYQNPNMTTFVDDYGQEFPKNRFLGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5B0</accession>
    <name>I4Y5B0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960814.1">
        <property type="nucleotide sequence ID" value="XM_006960752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5B0"/>
    <dbReference type="GeneID" id="18474643"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61619"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y5B0"/>
    <dbReference type="OMA" id="NDRLEWI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32165" checksum="5AAF5C314645C1D0" modified="2012-09-05" version="1">MITSTEIFGLLSVFSWLCAQIPQCYKNYRLKSIEGLSLEFIVSWLIGDLLNVVGCIFSNQLRFQLVLSIWFVFVDIILTQQYISYKDTQDERGRPVTRMLTHRQTVSLSINRVATRPPLTNKGAKRSQTHSVQRTGRSTSRSRSIASLLILTMTLGVSAAPTITPSQVNSEISATVGKLSSWACVTFYLSSRMPQIYYNYQRKSVEGLSVYLFIFALLGNSCYTLSIMTSPQLHQSRPLAVEYLLKSLPFLIGSFGTILFDIIIILQVIIYKNNYTSEERQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X9</accession>
    <name>I4Y5X9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_70608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960521.1">
        <property type="nucleotide sequence ID" value="XM_006960459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X9"/>
    <dbReference type="STRING" id="671144.I4Y5X9"/>
    <dbReference type="GeneID" id="18475764"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70608"/>
    <dbReference type="eggNOG" id="ENOG502RVEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716116_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5X9"/>
    <dbReference type="OMA" id="YINADTS"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="210"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="386" mass="43235" checksum="D404DF81B5ECC03B" modified="2012-09-05" version="1">MVPTYELLRQYTLWSEILYPQTYSGYVGTLYRSPVLSTVDQVLSLRATIPKVLVCTPNGLADAFLHDPTLFNTREKHNVVQNLNCIALDEVDALLPTKSIRRTSRSFKKAPKKKKDVLYPIVDALIGGSDHKIQFIATSASLNAPLRGHLKVEKRWAGPATSYINAKPSERDCQVKHSCVVVNTHGEIRNIRTTEDTNNGSKELQIRRSQISKFVGETNEDENLFESIAAAFAIWNAKSNSRGSAILIVPSNASIKRLEDFFSELDVDARQLVNLSKEDDESGLKYEEDTEKDSSTLYIVHEHAARGLHMPSLELVMIAGPIKDVTKYSHIAGRVGRFGQKGTPQVVTFVRETITDDKVNGEEEQAMLHTFDRAKINPEPWNTVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y9</accession>
    <name>I4Y5Y9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein bem46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_22539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960531.1">
        <property type="nucleotide sequence ID" value="XM_006960469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y9"/>
    <dbReference type="FunCoup" id="I4Y5Y9">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Y9"/>
    <dbReference type="GeneID" id="18470926"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22539"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y9"/>
    <dbReference type="OMA" id="QYWTSED"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="291" mass="33105" checksum="EE2C69C1B4B535C0" modified="2012-09-05" version="1">MNYLEILSSLTVIAFSSTGLLLYLYQTSLIYPANLPANSREFVDTPDLYDIPYKNVTLLSDGYKINCYLLHQADKAVKTPTVLFFHANAGNMGHRLPLAEVFYKRFNYNVFMVSYRGYGKSEGKPSESGLRMDAEVALRYLKKEELTRDNEIILYGQSIGGAVCIDLASNHPDDISALILENTFRSIPSLIPTLLPLLRPFTFLCTEIWNSEQSIKKIKTHILFLSGTQDEIVPVSHMRKLHNIHQSSVKDGIISSFKSFPNGTHNDTCLDRKYWNTVEDFLLEINQHNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y608</accession>
    <name>I4Y608_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960550.1">
        <property type="nucleotide sequence ID" value="XM_006960488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y608"/>
    <dbReference type="FunCoup" id="I4Y608">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="18474557"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61481"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="I4Y608"/>
    <dbReference type="OMA" id="TATITFM"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="554" mass="59835" checksum="FD90C9B1BE814A98" modified="2012-09-05" version="1">MPSERDALLNKSGDVWKPTLELRIIQLVTWANVFLVGFDATIAAATYAIIGSSFQDANNAVWISTSYLITSTSFQPLYGRLSDVDMFGRRKCFLFATTVFWLGSLLCGVAPNMLSLNLARAFTGIGGGGLQSVATIILSDYVPFQHRGKYQSANNLWNGLGAALGASLGAWITERFNWRFMFLVQLPVCTLGIIGGAIYIKEPNYVKGPLEDDVANKKQLKDIDILGSLTLVLGLSSLLAGLNLGGNDKQWSDPLVVGFLVSAAVFLIGFWIVELNAVAPILPPRLLRSTLAYSNITTNFFSGAACISFLFLTPLYFESVKQESSGTAGRRLIVPALGFPAGALVAGYVMSRYGYLNRLVQVGCVIATIGCALPLNFDSSGTNSDATYFWSLVPTNIGQGLINPSSLFTMLAAFSHAEQAVSTSVVYLFRNVGSVFGVTVTATIFQNYVMVYLPDALSGLDNSDDIVDKVRKSVDAIHDVPIEYRLAVKSVLANGLKSAYGCSTLFAIFALVSSYWAYGGSLERKDSDETLSAQYVSQGEEELSQEITIPVCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y622</accession>
    <name>I4Y622_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_66394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960564.1">
        <property type="nucleotide sequence ID" value="XM_006960502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y622"/>
    <dbReference type="FunCoup" id="I4Y622">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y622"/>
    <dbReference type="GeneID" id="18475111"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66394"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y622"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="373" mass="41002" checksum="ECF2EF508F12DEF8" modified="2012-09-05" version="1">MTKMYNLFCMLAVTITVVTTLSNALYLGDSRYSLTRRNLSLKGYRRNDITIDRERRQTGAKPRLPTLDETNTVSTQQATTGNAGNILLYRRDPNRLPKVSEVNLQLEQRPMKGLNGLITPGRVIRSQRKNGGIFRSHTHHNKAPAQLRTYDYAERNGYVRGIVKEIIHDAGRGAPLARVVFRDQYRYKLRTETFIATEGLYTGAFVYCGKKAALAVGNVLPVSQMPEGTVICNIEEKSGDRGALARSSGNYATIIGHSEVDGKTRIRLPSGAKKAVVGSSRATVGIVAGGGRIDKPLLKAGRAYHKYRVKRNCWPRTRGVAMNPVDHPHGGGNHQHIGHASTIARDAPSGQKAGLIAARRTGLLRGTQQVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y630</accession>
    <name>I4Y630_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960572.1">
        <property type="nucleotide sequence ID" value="XM_006960510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y630"/>
    <dbReference type="FunCoup" id="I4Y630">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y630"/>
    <dbReference type="GeneID" id="18475770"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70647"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023001_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y630"/>
    <dbReference type="OMA" id="SANQSKW"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="65"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="381" mass="43310" checksum="3A2BD686577932F3" modified="2012-09-05" version="1">MNSSLLNWCKEHSVELDSRLLLLTDRVLSNDYILKSTPIAKVPKDALLTIRNSSMHQQLSQLNQSRVVLLSFALAFEIHRGERSTWLSYIESLPKEAPDIASLWLPTPEMDGMELAKELDSLCNTKEGIRGRHSRAQLEDIFHTSLAPLADGISFNDYLYAYAITSSRLFTIDNYHDVGLVPVADLFNHTEESTVEFESDTLVCGCCGNLSHSQTNDKQTVDIVTTETIEPHQELFNSYGDTLSNVQLAMDYGFTLDANEFDRVRFDGDAIAFQWEFNDSDQELFVNDCNLYIDSEARVSLGLFGVTDIAIIDHIVMAYEQSSKVAEKPLREYIQCLIDKIDARLKEYPMHVNITNAMLVQMRQDEIGLLETSKRRFKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y668</accession>
    <name>I4Y668_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_70583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960492.1">
        <property type="nucleotide sequence ID" value="XM_006960430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y668"/>
    <dbReference type="FunCoup" id="I4Y668">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y668"/>
    <dbReference type="GeneID" id="18475762"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70583"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y668"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="157" mass="16564" checksum="29F5F5364DF3181A" modified="2012-09-05" version="1">MSVTRGISNIAKRGLHTSPATALQATKAATQVATGSYVEGTVNDPTRFPPPNSAHGSSHWAFERAVSAALVPVIGASFITSSHPVIDGLICSSLLVHSHIGFDASLTDYLHDRKFPKIGPIARWSVRGLTLGAAIGLYSFQTNDIGVTELVAKLWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6F7</accession>
    <name>I4Y6F7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_30256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960347.1">
        <property type="nucleotide sequence ID" value="XM_006960285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6F7"/>
    <dbReference type="FunCoup" id="I4Y6F7">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6F7"/>
    <dbReference type="GeneID" id="18471135"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30256"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6F7"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="388" mass="44086" checksum="4054B9C34C40B6F0" modified="2012-09-05" version="1">MDPSMPIVIDNGTGFVKTGYAGSNFPEHVFPSILGRPILRAEERVGSAEIKDLMIGDEAEQYRTYLQVTSPLEHGVIKNWPDMKKLWDYTIYDKLRIDPSGRKVLLTEPPMNPLANREKMCQVMFEEYGFDYVYIAIQAVLTLYAQGLQTGVVVDSGDGVTHVVPVYEGFALPHLTKRLDVAGRDVTRYLIKLLLMRGYAFNRTADFETVREIKEKLCFTSYDLEADKQLAEDTTTLVESYTLPDGRIIKIANERFEAPECMFQPHLVDVEQPGIAELLFNTIQSAAVDTRSELYKHIVLSGGSSMYPGLPSRLEKEVKQLYLQNVAGGNPERLKNLKIRIEDPPRRKHMVFVGAAVLGQIMAQRTNDFWVSRQEWLEEGPRVLQKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6G4</accession>
    <name>I4Y6G4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_66192</name>
        <name evidence="11" type="ORF">WALSEDRAFT_66438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="12">CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960354.1">
        <property type="nucleotide sequence ID" value="XM_006960292.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960607.1">
        <property type="nucleotide sequence ID" value="XM_006960545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6G4"/>
    <dbReference type="FunCoup" id="I4Y6G4">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6G4"/>
    <dbReference type="GeneID" id="18475093"/>
    <dbReference type="GeneID" id="18475116"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66192"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66438"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="459" mass="50089" checksum="DF25682148C44474" modified="2012-09-05" version="1">MGKEKLHLNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYNVTVIDAPGHRDFIKNMITGTSQADCAILIIGGGVGEFEAGISKDGQTREHALLSFTLGVRQLIVAVNKMDTTQYSEARFTEIIKETQNFIKKVGYNPKNTAFVPVSGWNGDNMLEASTNMPWYKGWERETKAGVLKGKTLIEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGTIKPGMVVTFAPSAVTTEVKSVEMHHESLEAGYPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKEAASFNAQVIVLNHPGQVGAGYSPVLDCHTAHIACRFSELVEKIDRRTGKTLEASPKFVKSGDAAIVKLVPTKPMCVETYNEYPPLGRFAVRDMRQTVAVGVIKSVEKTEKGGKTTKAAEKAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6M9</accession>
    <name>I4Y6M9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="14">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_66127</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="14"/>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960284.1">
        <property type="nucleotide sequence ID" value="XM_006960222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6M9"/>
    <dbReference type="FunCoup" id="I4Y6M9">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6M9"/>
    <dbReference type="GeneID" id="18475085"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66127"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y6M9"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="335" mass="35579" checksum="6AA6B272565EE6D3" modified="2012-09-05" version="1">MASLGINGFGRIGRIVLRNALEHGGVNVVAVNDPFIDLEYMVYMFKYDSTHGKFNGEVSHKDGKLIVNGKEIQVFAERDPAAIPWGKAGASYVIESTGVFTTIEKAGAHLKGGAKKVIISAPSADAPMYVVGVNLDSYDPSQTVISNASCTTNCLAPLAKVIHDKFGIVEGLMTTVHATTATQKTVDGPSGKDWRGGRSAGQNIIPSSTGAAKAVGKVIPSLNGKLTGMAFRVPTTDVSVVDLTARLEKPASYEDITKAIQEAANGPLKGILGYTDEQVVSNDFIGDVRSSIFDKNAGISLNNNFVKLVSWYDNEYGYSRRVVDLVAYAAKADGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U0</accession>
    <name>I4Y6U0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_21901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960190.1">
        <property type="nucleotide sequence ID" value="XM_006960128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U0"/>
    <dbReference type="FunCoup" id="I4Y6U0">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6U0"/>
    <dbReference type="GeneID" id="18470904"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21901"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014853_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y6U0"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="9">
        <location>
            <begin position="96"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="612" mass="69864" checksum="61FCBA5624A7B5E1" modified="2012-09-05" version="1">MSLGGKLENARKFHNKLSDLDTQQQRLSGGLDMVRKTQSLQSSLRMLDMAIDERDYDQASLYAQRALSIPHSIINSEFADTVIPSTHHPEPPLQRLDNSLDTLNEIFIKHFNDASANLNQMEISRFFKLFPKINKKLDGITVYSNFVVSLIQRKFKGSLESLSSVRILLDHLANVIEDHQPVVSKYYGEEYMYTVLQTLLKELDEKADIIFKNWSSGIVDIDTSDFKSTNAIISQITSLSSHWSAFKLFILSNLGTEDKYKQLLHSSRTSALLNQYLNENYISLEMNYFKNSLRKAIEVDETDEDSTPYTSSVLDDAFYVYKIILDRLVGCGNISILKNALGSITDLFETVLIDNLQSEFAKAIKPRTSKMISQQAKTNYNTYNTYNHKSKIVRVSACLNNLDLCSEYNIRILSNLMNERTLQRSYEDVDMAFVRDTLSGLKRMSDTAQSCLANCVDIFFTSTFKSNIKEILKTAINVTNYDKSVDHQSTLFVVIFEREWSQLFDEWATGLTTNNFDEVFVKAVTNLIQLWENIVFNSRFSGSGAIQFEKDVHGLLSLLNGMSTVGIRESFSRIRQISSVLNETSDENSSHYWKLSNSEIQTLQSMKLSNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X5</accession>
    <name>I4Y6X5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960225.1">
        <property type="nucleotide sequence ID" value="XM_006960163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X5"/>
    <dbReference type="FunCoup" id="I4Y6X5">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6X5"/>
    <dbReference type="GeneID" id="18475726"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70387"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053731_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6X5"/>
    <dbReference type="OMA" id="EFGEDTY"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="302" mass="35697" checksum="42FBD15ED2C541F7" modified="2012-09-05" version="1">MSDAERNKQIQLNRLRAKEALKERDKITSKSRELNNNNKRNLKHVEGHDEDVHNKSRRNASTSDSSQPLRRDPRLGQYYEYDLSKMQNSKGGFLIEDDHGLGEKTENEIRKEKQREMERTLAASYEPGLSIDLNANPKCKLCSSIETDRQILQTFGIIVCHKCKQAHPEKFSLLTKTECKEDYLLTDSELRDAEIMPHLLKRNPHRASWNNMMLFLREQVEDFAFKKWGGPEGLDKEWERREQLKHNKRGKKFQDSLNDLRRRTKNNVWQQRQDAQHVHDWTTQDDKQICNVCNLTVDVEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y752</accession>
    <name>I4Y752_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_65984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960128.1">
        <property type="nucleotide sequence ID" value="XM_006960066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y752"/>
    <dbReference type="STRING" id="671144.I4Y752"/>
    <dbReference type="GeneID" id="18475074"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65984"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039872_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y752"/>
    <dbReference type="OMA" id="CEESCCG"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="371" mass="40591" checksum="44AD82641106BE3A" modified="2012-09-05" version="1">MIEKYIARLAFFGNIWRGHRSSSCTHDDRPLFEVKRKGRPPAQCPKCKQIRKNDKGSNGCICPSESTILPKKDGPPPRKLKKGERAPLPEKPHYPNGLKDAYSTLVPLPTANKGEPSTVSLERLMNPCKCKVGGRCNCSAKKREILNDMLPSITDVIGKCACGPTCACPGCLTHGNPPLPLEEESATCGCDEIDVQGLLNKTQCGNLEEFLHKASSLVPYPPQGLNSTIESYVDGKAFGLQSWQQLYDPRNKGITRLPPLETECCGGSCQCQEHGVDCEADKKSKADLMPPPPPIMRTSTQEGSSCCSKGNNDSGENNNGFMSPTTLTKAISQPNGLKIPQQLVSPPTPNNHWFPKFIPQENKQDSFLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y764</accession>
    <name>I4Y764_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960140.1">
        <property type="nucleotide sequence ID" value="XM_006960078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y764"/>
    <dbReference type="FunCoup" id="I4Y764">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="GeneID" id="18471750"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33801"/>
    <dbReference type="eggNOG" id="KOG3574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020502_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y764"/>
    <dbReference type="OMA" id="RRKSWIM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="540" mass="60289" checksum="83C238D0142C862C" modified="2012-09-05" version="1">MPARKKASRNNLKYSRSPKVMPKNKLPDLESHLEAKQSDSNRPPQSTGLFDIWYHKDRSAMIILVILYLLQGVPTGLAFGSIPFLLKSKLSYSQIGVFSLSTYPYSLKLLWSPIVDACFNQKLGRRKSWIVPIQFLVGAMMYWMSFWIQDSLAQEVPDVNLLTFTFFSLIFLAATQDIAVDGWALTLLSHENLSFASTAQTIGLNTGYFLSFTVFLALNSVEFSNKYFRSTPLDYPLVTLGGYLQFFGLVFVLFTIWLAFFKKEENVIENQDEMDIKKVYNQMLSILKLKHVQSFVIVHLVAKIGFQANEAVTSLKLLEKGLSREDLALAVLIDFPVQIIGGWLAARWSQGRNPLKPWLGAFVGRLAYAIVAMLAIKLIEPPVTSSVFASVIAMTLVGGFMSTVQFVGICAFHTQIADPLIGGTYMTLLNTVSNLGGTWPRYFVLKAVDGLSIATCHVHEENEDVIVKAQECSSEHGKSLCTDIGGQCVVERDGYFVTSTLCVVIGTVILFTYIYPTARKLQQLPLSAWRIKTKSASHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y785</accession>
    <name>I4Y785_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1753-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960161.1">
        <property type="nucleotide sequence ID" value="XM_006960099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y785"/>
    <dbReference type="FunCoup" id="I4Y785">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y785"/>
    <dbReference type="GeneID" id="18474447"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61300"/>
    <dbReference type="eggNOG" id="ENOG502S1XC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063116_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y785"/>
    <dbReference type="OMA" id="CEVIVWF"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="210" mass="23392" checksum="8A64EEA6740BF7F7" modified="2012-09-05" version="1">MISGLGKLADKSPLNKPIFRSLCGLDIKLGCTIITAFALFNKVAGVYGVNVIFTGGTFAQLSMYLYSVGTLAVFVWGLKQISEENPSNSLAYANLFAIDHIISTIYSLIFFKHWYIDEPHDGRRADVGDLTKGWGGVAHQDLTELERVAAAEEVWGREKVFAALVLLSGFIAKLYFILIIYSFSLSLIQGTYYNNNQQTNRANYRNVQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y797</accession>
    <name>I4Y797_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_52570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960173.1">
        <property type="nucleotide sequence ID" value="XM_006960111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y797"/>
    <dbReference type="STRING" id="671144.I4Y797"/>
    <dbReference type="GeneID" id="18472587"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52570"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010794_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y797"/>
    <dbReference type="OMA" id="KGWASRA"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="783" mass="86126" checksum="FB222370B910C233" modified="2012-09-05" version="1">MPHLYRHFRVNQVFGANTDVGKTLLTTALLLAESRRTANNIYYLKPVSTGPDAEQDDAFLQRFSTTDRIKHHTLYRYSDPVSPHLAVSRESVEKKPPSDKEFARSIGDYITNTAALPNTHSLYVETAGGVHSPTLSGTSQADAYRPLLLPTIFVASYHLGGISTTLAAYESLHIRGYNIDTILVFKEEYYANYQYLTEWAQERGIHVATIDQPPSRDSNALNDEKALSAYFNSLSTNDESPVVRALEELDRRHQARIDEVEGLPDRTLKSIWYPFAQHSHITSSSQIGVIDSAHADNFDVYRPNRDSTSLLKQEFDGSASWWTQTLGHGNPTLALAAAHAAGRYGHILFPGHTHKPVLELCERLLEGPGKGWANKAFVTDNGSTAMEVALKIALRAASKKYGRTQRGVIGLSGSYHGDTIGSMDASEPSVYNNAVEWYSPRGGFWFDAPLIKYKSGKVILKGAVAMGVPENAVVNGDYWEIAISDSLSDAYNLDKRIKSDLSTLYRDFVQQTLIKLVGEGRQFGALVLEPLIMGAGGMLSVDPLFQRVLIDTVRANEKLFAEQAGEAYTEGQEWDGLPVIFDEVFVGLYRLGQLTPVSILGTAPDVSAYAKILSGGIVPLSTTLARQSMFDNFLGEEKKEALLHGHSYTAHPIGCSVANSSFEEIKKLTTSDDWKASKSAWNSESENAIWSLWNPETVKTLASLDNVDGVLALGTVLVVHLKSSGKGYESGGGQRFLATLANEGIHSRPLGDTIYFMSSLNTSRETIREVESKVIEGIKKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7A8</accession>
    <name>I4Y7A8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16 subunit, GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_40883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960184.1">
        <property type="nucleotide sequence ID" value="XM_006960122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7A8"/>
    <dbReference type="FunCoup" id="I4Y7A8">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7A8"/>
    <dbReference type="GeneID" id="18472195"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40883"/>
    <dbReference type="eggNOG" id="KOG2407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021459_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7A8"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697675" evidence="2">
        <location>
            <begin position="17"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="495" mass="56095" checksum="44356D193F568508" modified="2012-09-05" version="1">MISWLFLSFIFGYVASTDSFNEYLTTNPLQDGRVDVGFNFTITDSEISPHTNLFPLPLVNLLRSPEIDIDELHLSLSAGIWDYSKWHYPHFPQLGSSGIELWVSHNSDSTPTKWNRLVHTLSGMFCASFSTSDNAHQVELKGKTWTHAQIASQLPCTENLTPFIALLPCKSSAGLGQLLNPHKLFDADYHSLGLSLYRTDNGARVEIMIEAVMNPTRVNQQRQYSTKGMLDRSVNSPCPLADSSKVYFNLPPTPQQGHDEDLWVVLPEDHDGEVKDGIVDLDIMQSVKPLALSVVYPFQEIFTYPKSITNPPLLIRRDQIAGPIEETMLVRTVVENTEDNDRQVSYFHSIPWQIEPWLHTFTINGGLNDTSYKHSLGEAKKDPYKLQVNATIPAHSQLTIECLYQRQFLQYADYAPDIHRGVDIPPGVLLFNRDDETRFQYTTPLLIDLATPDFSMPYNVIIITSTVIALFFGSVYNILVKEFQLIPRKEKAKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B7</accession>
    <name>I4Y7B7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_11275</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959997.1">
        <property type="nucleotide sequence ID" value="XM_006959935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B7"/>
    <dbReference type="STRING" id="671144.I4Y7B7"/>
    <dbReference type="GeneID" id="18470591"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_11275"/>
    <dbReference type="eggNOG" id="ENOG502SBWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142427_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y7B7"/>
    <dbReference type="OMA" id="MTREYET"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="83" mass="9184" checksum="C8B0970BD4C4FDF1" modified="2012-09-05" version="1" fragment="single">ESTHFEKEKERLVKEIGHEFEQALNNSNMLGRRLEEVLGVGKEFNTIAALWGVFGNIVGKDTKEDDNDSSSSIIHQQGIPGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G2</accession>
    <name>I4Y7G2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960045.1">
        <property type="nucleotide sequence ID" value="XM_006959983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G2"/>
    <dbReference type="GeneID" id="18474414"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61245"/>
    <dbReference type="HOGENOM" id="CLU_1579721_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7G2"/>
    <dbReference type="OMA" id="AGISNMF"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="169" mass="17971" checksum="A51DFD92CDAD9BCE" modified="2012-09-05" version="1">MSESINIPHRQRSSSESTTSSLNHKPSSVKAALPSTSPFSSQPFKETSVSPTQPQTLSIQPPRRPSGSFELSGQPSPPGASGNSGITSLFRRFSFKGTNQPPSSQPNETPGGLNTIPAKQPLMSVEQPEQPATSVSPKLAPGRRKSDQKRSVSPMGERILRGSFDGNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H5</accession>
    <name>I4Y7H5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Erg28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_61254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960058.1">
        <property type="nucleotide sequence ID" value="XM_006959996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7H5"/>
    <dbReference type="FunCoup" id="I4Y7H5">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7H5"/>
    <dbReference type="GeneID" id="18474420"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61254"/>
    <dbReference type="eggNOG" id="KOG3455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7H5"/>
    <dbReference type="OMA" id="NIAIWTY"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="15097" checksum="C8C142DB72DA07AB" modified="2012-09-05" version="1">MNIIPNGPGLLPKWMLFVSALAIFNSIQNCLTTSLTARIYNHKPQLVNPLQARTFGVWTFTSAIVRFYAAHNINNKVVYDIAIWTYAIVIAHYISELLYYRTSKLSAGIISPLIVGTASFVWMITQYDFYVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7J1</accession>
    <name>I4Y7J1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_65934</name>
        <name evidence="5" type="ORF">WALSEDRAFT_70282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="6">CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960069.1">
        <property type="nucleotide sequence ID" value="XM_006960007.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960072.1">
        <property type="nucleotide sequence ID" value="XM_006960010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7J1"/>
    <dbReference type="STRING" id="671144.I4Y7J1"/>
    <dbReference type="GeneID" id="18475069"/>
    <dbReference type="GeneID" id="18475707"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65934"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70282"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147959_0_0_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="129"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="242" mass="28116" checksum="BCCAC9AB0ED2A040" modified="2012-09-05" version="1">MTIFYNQPSNFEFPIEFFIEEVAPRKHVNTAPSTSKPRLDLLEYENSYEARLNLAGYKKEELDISIHDHKITVKATHPAEEDKDNGFSYLINESRLKHTMTIFYNQPSNFEFPIEFFIEEVAPRKHVNTAPSTSKPRLDLLEYENSYEARLNLAGYKKEELDISIHDHKITVKATHPAEEDKDNGFSYLINESRSSSIASRTWKLPEHVTEDNIHASYTDGLLTLRYSRHAPESEPKRININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7P4</accession>
    <name>I4Y7P4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959917.1">
        <property type="nucleotide sequence ID" value="XM_006959855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7P4"/>
    <dbReference type="FunCoup" id="I4Y7P4">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7P4"/>
    <dbReference type="GeneID" id="18471722"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33632"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013933_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y7P4"/>
    <dbReference type="OMA" id="VHQLNNA"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="623" mass="70091" checksum="31E520A841FB9D6F" modified="2012-09-05" version="1">MNVIEAVNNYINKLVNEVKGMKVLLLDDSTTSYLSAVTTQTQLLSSEVYLTDRVENLNRERISHLKCIVYLSPTANSIKYLSSELSNPKYQEYFLYFSNTLTKQQIEQLAESDQYSVVRECQELFADYLALLPNLFSLGFQPTKDNLWSDTPNTWNRDCLDSTTKSLSALLLSLKRKPFIRYEKMSDLAKTLAESVSTTIDTESQLFDFRLTQSQPVLLICDRRNDPVTPLLTQWTYQAMVHDLIGLDNGKVDLSQAPNIQPQQKQLILSVTNDNDSFYTNNLFANFGDLGANVKQYVSEYQTATTGKGTTADNIQTISDMKKFIESYPEMRKLGSNVSKHVSLIGELSRLVDEKKLLQVSELEQSLASNESHSSDLRAVREMIDSPDIPQESKVRIAILYALRYQKLASNAITAVVGQLLQQGVPQHRVALIYVMLNLAGADKRQDDLFMNDNFFSRGRSALKGLQGVENVYTQHTPHLSETVDLLLKGRLREGSYPGVNADGGSLNQRPQEVIVFMIGGTTYEEARSMALLNETMAREGSPTRVLLGGHTVLNSTQFLDMLAEAATHFPPSVYSAPPSSQNQNQLFAVSEMDQMLDPERMASAAKSWMQRVREDIEDRIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y876</accession>
    <name>I4Y876_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Root hair defective 3 GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="11" type="ORF">WALSEDRAFT_33605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959888.1">
        <property type="nucleotide sequence ID" value="XM_006959826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y876"/>
    <dbReference type="FunCoup" id="I4Y876">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y876"/>
    <dbReference type="GeneID" id="18471715"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33605"/>
    <dbReference type="eggNOG" id="KOG2203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y876"/>
    <dbReference type="OMA" id="PIIKMTE"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="692"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="716"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="10">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="766" mass="88033" checksum="897E1F43B1D9146E" modified="2012-09-05" version="1">MTSRLHVINEEKIFSNNLSSQLNQWQLSNSGFNYNVLSVFGSQSTGKSTLLNKLFGTSFDVMDESQRRQTTKGIWMCKALDIPLLVMDVEGTDGRERGEDQDFERKSALFSLAASSVLLINMWEHQVGLYQGANMGLLKTVMEVNFSMFIANSNSDNTEKPPKTLLLFIIRDHLAITPLDNLRTTLTNDIENIWNSVSKPENLTEANLSDYFDLDFVTLPHKVLQPEEFDQQTLRIRNNYFSDKDSKEFALKPEYHRKIPADGLSHYLETIWDKVQNNKDLDVPTQQELLAQYRCDEIASETLKIFHNRIISVKKPVEIGKFVPELGKVMRDAEKEALEMFDDIAFRYAKPVYDKKREELVDSIRTTLSPLYISQVRNLHKKAIDNFKKELHTRLKSDSYDFSNVVKESSQHHIETFVEQANEITLQGTDWSYIETLEQLKLDIDTVSAECRSEELLKLIKQLDRTIQKEAGEFVEVCLNHPDTDMWDKVLGRFNALLDRSKTSYNMKASKLNSTQKEIDATTGSLLRRAWISLRNKIEEQCSEAILLFRLRSIFEDKFRYDNKGIPRVWRPSDDIELIYTDAKEHTLQLLKLYRSIQPQDEEKVFSYPQLDDTVQDIIRVSDEEESYNYEESLQVLGEAKEAQLAARFKKDADAIYVEAKRSVVSSISKIPLWFYVALLVLGWNELWAILSNPIYLTLSLLGLVTAYFVYTLNLGGPISTILVTVGKEVNRIIVEKMVNLQAETRDTAPTGTGKNSDTLNADTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y881</accession>
    <name>I4Y881_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959661.1">
        <property type="nucleotide sequence ID" value="XM_006959599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y881"/>
    <dbReference type="GeneID" id="18474300"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61039"/>
    <dbReference type="HOGENOM" id="CLU_1732908_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y881"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="16837" checksum="00222B1CB3D96F14" modified="2012-09-05" version="1">MISQIIGAELVDTSFLVGFFFGSLAIPISFVTYITLARGMAVWVNYRASIDFYDHKDCVTFRVPLWSYWKGSSNPDSGEKRMKGCEPREITFISISDRKLCRKLCVGTYAFGVAGALAFASINTIGYAGCAWAYAFNYRREFEGGRVLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8B2</accession>
    <name>I4Y8B2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959692.1">
        <property type="nucleotide sequence ID" value="XM_006959630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8B2"/>
    <dbReference type="STRING" id="671144.I4Y8B2"/>
    <dbReference type="GeneID" id="18471684"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33455"/>
    <dbReference type="HOGENOM" id="CLU_703157_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8B2"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="44697" checksum="C6ABE01A9A9B2291" modified="2012-09-05" version="1" fragment="single">MQNDNLFKNVQQLGQMFASGNKPSFEDFTFSPNFNKKDKKKNKKNKNKISPEEPLEPRVGDSDLEWGSDGPPEPKNNQSKKTSKPKKQTIDDAIVADWLENSRQDDSDDDDSGGEAAAGPFGADDSALRSFVDNMSRNQNSITDLKIDKRLRKEAVEEEEWDDGSSVDSVEFDSEFEKEENFKFGFSDNDSVDVDIDDNEIDLDSSLSSEEAYELGRARAKAAKKEGIVTERSRKGKGKKKADDFHDFDKLLEFDDFEGKHNKWDEEEQYLDELAAIIENKRQDIQKARSSSSRQASRQGKYSYDDYGDVYGDDSEDDFAIDPSDIIFPTSSKKKKSKVPPQLQRLWDQDRVRKAEKKKVREQIRMADALSPYTKTKGKKAKKMQARAIKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D6</accession>
    <name>I4Y8D6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_69992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959716.1">
        <property type="nucleotide sequence ID" value="XM_006959654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D6"/>
    <dbReference type="STRING" id="671144.I4Y8D6"/>
    <dbReference type="GeneID" id="18475671"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69992"/>
    <dbReference type="eggNOG" id="ENOG502QUQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318634_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8D6"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="913" mass="101836" checksum="9855A367FCA3C498" modified="2012-09-05" version="1">MDDRKPEQNGHISTNKPGIYLPPMASHPTLQTFVGPSASYSQNSAERVPPIYRHLHDHPPPEFSSQQPKPAQYSQKKPKRKSQTDASPDSSAVDQQTGQPIKKRQRTARSCDSCRSRKIRCDFLPDEDPPCCKHCKHNGLPCTSNLPISETRFKKRSSSAYAPETTPILQAQPQPQSQSQSQPQPQPPPLQPPSQPQPQPQLQPQPQPPQRLPQPQPLRQLSVPMDVPPSGVNISVPSAPPPPSGFPIRLPPIGRENMKLPPLNSESRMLGPTSISYLVHSQAQLPTSVERNLKDVDDRYHQKSSLTPNGDGWIHQMQNRPGSSHDRIQKPPTIQKEISQTRQTNDLPLDEETKQMLLDIYFSEIAPIFPVLTSEEFYSHPHPLLLKACCVIAATGRQVPLETLNVCRSALNDSLAGSTLSRSSLVTIQALLICSLNTDAHSTALGSSGSSIWLRSGAAIRMAHDLGLHKESNECTQWESNRRRRVWAAVVIMDRWASCAHGLPMTINLVDCDVLLPSPFEFYKDEQSEDVKPIIKEDENKPYSFFVEMVKNSVLLGRILQTLYSAVGLRLVTDEQLFSLAADIEHWREDLPNNLKFTGSSSSPQAGVLQMAYVTLCLLLFRPMMRASENEMSDELKHTLDETRWNKVYIASTECIDWVYQNQKIMDHWFIAVYCLCSCALIQHHTWVRLQDERALDSLHKVVEILEQWQRGGGGDDAITWRNKLTDIIHILNKSATRAKSGTQSVSEPDGSRMRRNTSQLRYSEDKRSDSSGGFNQNQSTFTGVVESQQQQPPYAAGAQNGVMSYAALSTNRDDLESVQSPFQIGQTPSYPNQPIYSSVIDDSTPHHAFFDLNAWDVLMQNFHPVGSSGGGNATTPNHGVADVHPPQNTQNSATNAIPNVTYGHTKPSFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8H1</accession>
    <name>I4Y8H1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959751.1">
        <property type="nucleotide sequence ID" value="XM_006959689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8H1"/>
    <dbReference type="FunCoup" id="I4Y8H1">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="GeneID" id="18474322"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61078"/>
    <dbReference type="eggNOG" id="ENOG502S6UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101052_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8H1"/>
    <dbReference type="OMA" id="PTIHGDY"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="107" mass="12360" checksum="A43137AD4936CD60" modified="2012-09-05" version="1">MMSSIRRVANLALNMKNIRLSSNFNRPGPPLLPPEEQREFEKLQKEATETTLLSDDNNDMHRDAVREARRTEFEGDINPETGEIGGPKREPLRWQSEWTYGGRATDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X5</accession>
    <name>I4Y8X5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959443.1">
        <property type="nucleotide sequence ID" value="XM_006959381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X5"/>
    <dbReference type="GeneID" id="18474240"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60908"/>
    <dbReference type="eggNOG" id="ENOG502SG9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1929215_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8X5"/>
    <dbReference type="OMA" id="NIMATPG"/>
    <dbReference type="OrthoDB" id="3366194at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="1">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="131" mass="15232" checksum="25D7363AA2FBF73B" modified="2012-09-05" version="1">MSDGYWLDSIDSKGLEGQALFEHRRKLWTQPTKKTEGRLQERRDNPGFRKLIELIDSAKDRENFTDIWDKGIRNIYNNLVQGQRLSQPLPLEIIVQVVCKAAWVELGIWPLDYVKTPDPAPIVPRAFMNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y901</accession>
    <name>I4Y901_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959469.1">
        <property type="nucleotide sequence ID" value="XM_006959407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y901"/>
    <dbReference type="FunCoup" id="I4Y901">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y901"/>
    <dbReference type="GeneID" id="18475647"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69809"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y901"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="180" mass="20296" checksum="D50EBB6651509FD6" modified="2012-09-05" version="1">MPAYHSVYNEDTTAKQIGNTSILPFKSQYRGVAPLPPNSEDYVDIITESILLFRANSLFRNFEIKGGADRLLIYLILFISDCIAKLSKTEPNVNEASKQLHTLAVDSFALPGEAGFPLNSLYAPAGSRMDGDYLRSYLTQARVETVNRLIPIFYSESQDKPSKWWMAFNKRKFMGKSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y915</accession>
    <name>I4Y915_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_47548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959483.1">
        <property type="nucleotide sequence ID" value="XM_006959421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y915"/>
    <dbReference type="FunCoup" id="I4Y915">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y915"/>
    <dbReference type="GeneID" id="18472420"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47548"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y915"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="344"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="435" mass="48476" checksum="FF3BBEF0AB6207EE" modified="2012-09-05" version="1">MHPFAKQREYSRAVIASKMDRMFAKPFIGAIECGDGVYGMARDSARLGVVATSGAMGELAIHDVPTRQTLLSVPNAHQGIVSSLAFSHTSKSLRGDSRLLSAGLDKHVRMWDANRSTDAGDDAGLIDEEDATAEQKPLRTWTANAGVNCITHNLLHPTFATASNAIQVWEEARTEPVETYTWGHDNISALKFSPTEHTIMAAAAGDRSISLWDTRVAGGSIGRILTPFKMNDLSFNPILPTLLLSAGEDHNLYLWDIRNMGGGAIQIYKDHVAAVTSCDWSPTGQQIASGGWDRTVRIWDKNHGRSSDCYHTKRMQRLMNVQYSLDSKYVLTGSDDGNLRIWKARASEKIGQMDARERDRINYRDSLRERWSGVGEVRQVERRRNLPKAIRNASKLKKTMVDSQKTKEENSRLHTQAGQTKPKSEKKKSVIKEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y934</accession>
    <name>I4Y934_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_39891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959502.1">
        <property type="nucleotide sequence ID" value="XM_006959440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y934"/>
    <dbReference type="FunCoup" id="I4Y934">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y934"/>
    <dbReference type="GeneID" id="18472138"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39891"/>
    <dbReference type="eggNOG" id="ENOG502QWBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y934"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="35083" checksum="70CAE6F6681B73B2" modified="2012-09-05" version="1">MLPDRARDAQFELMLLGTGTSSAVPILPCVTDPEQKCKTCLSDAKEDERGNTSAIVQVRANDGNMKTILIDCGKTFYRDSLKHFPKRGLRKIDGLLLTHGHADAMYGLDDLRAWTMRSIQDCIDVYTNEDTYQTVCNVFPYMVDSSKASGGGDVPSFRWHIITPGEQFDVAGVPVIAADVEHGLAAPRSISGDRSPFHCLSYIFPPFGIYMADVSRIPEESYKVIDNALEGKRPSILVLDCLKSQPHLSHFGLDQSLEASYRIKAKKTLFVGFGHERTHNSWIEHIDRNKSVDMDISPGFDGQAVEVDIEGNVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y954</accession>
    <name>I4Y954_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_39931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959522.1">
        <property type="nucleotide sequence ID" value="XM_006959460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y954"/>
    <dbReference type="FunCoup" id="I4Y954">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y954"/>
    <dbReference type="GeneID" id="18472143"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39931"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y954"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="47"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="16338" checksum="A8B58FCA449A6961" modified="2012-09-05" version="1">MTSIGFDEPELISRAFQALQRSYSPYSKFRVGAALVSTENEIFGGANVENASYGGAICAERTALVKAVSEGHKRFQALAVVSDLDEPITPCGICRQFIREFFSPETPILLVSQAHPANNASETSYKGPLIKRTNISVLLPDSFGPEQLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y958</accession>
    <name>I4Y958_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959526.1">
        <property type="nucleotide sequence ID" value="XM_006959464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y958"/>
    <dbReference type="GeneID" id="18474268"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60980"/>
    <dbReference type="HOGENOM" id="CLU_1961291_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y958"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="15033" checksum="6804D3FE9150D782" modified="2012-09-05" version="1">MRTKQHSVLESRGRSRYVNILASSQDELFRAIFPSWCNDNGDYSKLISDHELGTLIDLCERVGKKAIQHMPPKMHFCKEQQNPFNMLMSIVSKMPWSSIPRDKRKNLYRRYQNALNGEDRVLMIMSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y972</accession>
    <name>I4Y972_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959540.1">
        <property type="nucleotide sequence ID" value="XM_006959478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y972"/>
    <dbReference type="GeneID" id="18474273"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60989"/>
    <dbReference type="HOGENOM" id="CLU_2656349_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y972"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="76" mass="8798" checksum="7D7C199D77C35523" modified="2012-09-05" version="1">MRRFSIGRRLFQNLDNENGKLTMQQLKAMNEFNKTNLQKKANKVAHTDRQIEILKLEAQLEDISARLVDLKTGGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9B0</accession>
    <name>I4Y9B0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_55002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959346.1">
        <property type="nucleotide sequence ID" value="XM_006959284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9B0"/>
    <dbReference type="GeneID" id="18472709"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55002"/>
    <dbReference type="HOGENOM" id="CLU_1054494_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9B0"/>
    <dbReference type="OMA" id="RERWDMW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28050" checksum="B83F79D2CAB58913" modified="2012-09-05" version="1">MRGSRSVHYKRDIWYGDGNGSKVVVSPGGPTVDYTEQSESPTPTGSRTVINSVDTSEDYNIQANGTGSTPSDSSSSSGKSTPSSSLGPHKASSSDSSNLSAGPIVGIVVGVIAFFVFLFLCFGKYRRRMNRQKTMSFAKAQGMARSQPHYAPGAPIDDGSFRPTTFQMKNTNGAMTVKSQHSKSGSDTTNLFRKGSTASSLVPSDVNSLAAAPWFRSSGATTEESHSDVLLGMSRSDSDRSRYKKGRNSFGSPLDMLVRGIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9P9</accession>
    <name>I4Y9P9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959224.1">
        <property type="nucleotide sequence ID" value="XM_006959162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9P9"/>
    <dbReference type="STRING" id="671144.I4Y9P9"/>
    <dbReference type="GeneID" id="18474173"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60801"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="InParanoid" id="I4Y9P9"/>
    <dbReference type="OMA" id="HPILVMG"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="120"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="511" mass="56553" checksum="AE202A4ABAD70516" modified="2012-09-05" version="1">MLKIARIARNQLNKQQFVRCTSSSIPRTHPDAPSFPCVDANESRAAKLASQTNKLPFMRSVKIEDVEGEGPEPVYATPTPATYQTFTSDDPLLLDFGGVLPRFDIAYETWGTLNSDKSNAILLHTGLSASSHAKSHPGNETPGWWEKFIGPGPEFAIDTNRFFVICTNVLGGCYGSTGPSSPHPDDNKPYGTRFPIVTQFDMVRAQWRLIDSLGIDKLYASAGCSMGGMQSIAAAHLEPERVGSIISISGTARSGSTAVAMRFAQRSCLMSDPNWNRGFYYDGLPPHTGMKMARQIATITYRSGPEWEQRFGRKRRVTPLSEEEMATNVNNPGDAPKLCPDFLIETYLDHQGEQFCLKYDANSLIYVSKAMDLFDMTKPALMDIHERRLRNAHLIDKKLLGSTTSHSMEPPSLDSVKIKNLKPYISTAPTVPYAQDLTEGLTRLSKIPVLIIGVHSDILFPFDQQRELADSLRKSGDPERVKFFALDGPWGHDTFLIDTSNVGGAIRGFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Q2</accession>
    <name>I4Y9Q2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006959165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Q2"/>
    <dbReference type="FunCoup" id="I4Y9Q2">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Q2"/>
    <dbReference type="GeneID" id="18475611"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69618"/>
    <dbReference type="eggNOG" id="KOG3485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138804_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Q2"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="86" mass="9681" checksum="CBD451CBF4688C75" modified="2012-09-05" version="1">MVNNLNYIQNQQLERLHARYTGTGHPDISKHEWVTNQQRDTLSSIVGHPTLSSYMSIADGQSISRTKFNMIEAMISPAGPPPEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9V7</accession>
    <name>I4Y9V7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959278.1">
        <property type="nucleotide sequence ID" value="XM_006959216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9V7"/>
    <dbReference type="STRING" id="671144.I4Y9V7"/>
    <dbReference type="GeneID" id="18474191"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60829"/>
    <dbReference type="eggNOG" id="ENOG502S20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004010_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9V7"/>
    <dbReference type="OMA" id="WRMKLQE"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="595"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="822"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119546" checksum="6EBDFF7A775248B9" modified="2012-09-05" version="1">MDFTVSMSQTGVPKLPQFETGRRRSSLDRRSSVIKQNSGSPEGPSVVSMDVDNSSSSDDEENDQQMLLQPPPPAQIQTSQQSHSPSDSDSDSDGNGDDMDLTKAVTTQINTGDVDNNAQPQQEGDASVTMDMTQAIGGLLQNDKSQTEINDKSDIKEDQSDDDNSIASNNDQSMTMEMTQAVGGFTNFPTIPEEESSNSDNDNDVDATMTMEITRPIGKGILINDETRRLRKSLGPRMSRVSFAPSVKASPPKASNGPRPSLKSALKSSSSFEQSQSPKKAISPKGSPKDKTGKTRSSFSAPTQSSMLKKSSVRHSLGGALGGTTSSPLRSALKNASARSPGRAKKRASFAGDLRQENVEPSKPMSPLVQRLQLASPLRPPPFKLDVNGEKDEDDKSNKEEGDKHTKKPRRRSSLALSTHALEATPDTLASEKAKEEREKKDKERVYEKEVEEERKRKSTEEEKRIKEAEENQKTAADEQSHSTNDNSDAVDKSISGEKSQVQAPQLGTPTRRRSLHASQMTPSKLRNSIIASQTNSPNSTPKRQSLRLASSVTTPQKEAFAEEKAEPVAPPARDEFAAGPETEKMIEGLMQEDEDVDNESSVEAPVQISLNDFLDLTDMKFLDGISTIKRRSTVGVGGLGGLKQQSQKDPTSLDYLRAHNVTGPKLEMMYWCCHELKRYISEGIEALNSYEREVDNENPPVIVDYLLASEEMRIRIEAQLKIVKNNSRLDAKRVWYGWRKELVHGHSESINDSFKSLEKDIGVLKETRGALKEKLPELRSLREKLEVELRREREIVRDIASCDKEEVEGLREAIAEQAQPLELYKAEISSNNEELTRLRTRLEAKKETLSNNRLAIENNRNEWDMVRCLTKAEAMKRRREYESLQSLHSWHIQHLSQSHKKFNYAEDIEINITDMGVELILLPPKKGELGPLLEYLLDCLRGQLTEEGISHTTELSYTLQRVSTLWTKVKKVHSEFKNLAQMYRLLFTVSDEGDLVVKLSILKRLQKLQFEVTIGSDLLVDLSSALRKARIKTDVIIGEDVNVETITQSLMAKLSNTDDKSIVEAFDGIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W5</accession>
    <name>I4Y9W5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_20015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959175.1">
        <property type="nucleotide sequence ID" value="XM_006959113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W5"/>
    <dbReference type="STRING" id="671144.I4Y9W5"/>
    <dbReference type="GeneID" id="18470821"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20015"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="I4Y9W5"/>
    <dbReference type="OMA" id="HANKACQ"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="262" mass="28410" checksum="2FBFF51133DD1CD5" modified="2012-09-05" version="1">MSLVGKSVFITGASSGIGAALAKQLVVAGADVYLFARSTDKLKSLAEEIKLQNSEKKAQVAFSQDGDVTQYDKVKKAVDECIAAFGKIDILINNAGLALGAPRRFHEQSLEEIQTVNDVNVMGVYWATHAVLNGSMIKNNSGTILNVSSITGLNAPTFPGEATYHASKTSLEGFSNVLRHELTGTDIKVLVIRPGCVETHFHEQRVGYDKKLYDDFFSGFEQLTADEVAEGAISMLSTSLKVSINALNIMPTREYHEKISFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA29</accession>
    <name>I4YA29_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60718</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959083.1">
        <property type="nucleotide sequence ID" value="XM_006959021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA29"/>
    <dbReference type="FunCoup" id="I4YA29">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA29"/>
    <dbReference type="GeneID" id="18474120"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60718"/>
    <dbReference type="eggNOG" id="KOG0142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_0_1_1"/>
    <dbReference type="InParanoid" id="I4YA29"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="26268" checksum="B196FAECFB3376CE" modified="2012-09-05" version="1">MVELSKDEYDLEQIRLMEERCILLDENDNVMGDVSKKDCHLMDNINKGMLHRAFSTFLFRPSDGRLLLQKRSKEKITFPDLWTNTCCSHPLAIKSELDGIPGAKNAAIRKLEHELGIKGLKPDQFDYLTRIHYLAPSDSLWGEHEIDYILFIKADVELDINPNEISESRYVNQQELKDMMNDKDQYKLTPWFELIGDELLFKWWDQLLKGEKLVQDDKLYRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA85</accession>
    <name>I4YA85_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959137.1">
        <property type="nucleotide sequence ID" value="XM_006959075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA85"/>
    <dbReference type="GeneID" id="18474138"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60749"/>
    <dbReference type="HOGENOM" id="CLU_752738_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA85"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="368" mass="39973" checksum="B0C533EF5179C1A8" modified="2012-09-05" version="1">MLVIRSEDYILSKNNRLRRHFLNVPLKPLCCGAVVFTLLFALFGSVAGQAEPGLSLTDYTKFYNLDTGDFITTPKYDLSNFVLQKHKIGERFVWTWGATIVACKVLEIVGGLASAGCTIATAAGKLNVNGKIACGIVGAIAPLAGGVHWYAGAQVSKAAARVAAEQIRLDEAAIWLSEYVPSAYVRRKNENPGLKSFKNMVALPHSNADVSRRGSDQYSETGDLVSDSGIIGSYRGKYTSGVVNKRGIENTTDVSFGVKLETGVYELTGHQGSEVKRGLGGRDTSYYVGEDGVVVEINEDDSHWWEYTYNHYGQDAMYGVEADVGGKYQDTNGLGNWSMMSDTIWAMLIKLVPASVFKTMVNGCQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA98</accession>
    <name>I4YA98_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959149.1">
        <property type="nucleotide sequence ID" value="XM_006959087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA98"/>
    <dbReference type="GeneID" id="18474146"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60758"/>
    <dbReference type="HOGENOM" id="CLU_1836675_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA98"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="14921" checksum="8B807599485B3A91" modified="2012-09-05" version="1">MRKWTLSRVYDVTIDGETMSVYRDNNEDSQRSFKLPDETQCIASRYGYGAGSRYKITSLPDETILASFEPGKGSSIIGRLSLDTRGLDNRSSIALLTVMSIMLRIGTESTRTAANGTTPMMMVMLAGGSAGGAGGCGGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ0</accession>
    <name>I4YAJ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_32959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958972.1">
        <property type="nucleotide sequence ID" value="XM_006958910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ0"/>
    <dbReference type="STRING" id="671144.I4YAJ0"/>
    <dbReference type="MEROPS" id="T03.011"/>
    <dbReference type="GeneID" id="18471594"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32959"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="I4YAJ0"/>
    <dbReference type="OMA" id="GFMLVHL"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698730" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="391"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="442"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="568" mass="60633" checksum="CAB366A380FE90AD" modified="2012-09-05" version="1">MLENRLRLSLVALLAAAGASPSPKSPLPWFEAGKSGAIVSENNHCSNVGLQLLGEGGSAADAIIGTILCVNTISAYHSGIGGGGFALIKEESGDYKFLDFRETAPAASNKTMFIDNPHNSTIGGLAVGVPGEIRGLEYLHSNYGRLPWSRPFEIAAEVAEGFTIEQDLSAKIKSSDASYGFLREDPLWSEVYAPEGKVLSLGDTVSNKKLVDTYRKIGNEGPDTFYTGEIADNIIKAIQNSGGIMTHDDLKNYEILERDVLSADFDAYTVYSTSAPSSGAVVLSALNTLQHFDEEIWRNDNHTAQALVESMKFAYGIRGQLADPNYVKNVSDIQASAITKEAGEAFYNRISLDKTHEPDYYTVEPQELVEAGTSHLLAIDGTGLVISLTTTVNTIFASHVMTENGLVLNNEMDDFSTKGESNSFGLTASSVNFPEPGKRPQSSISPGIVEDKDGNVVLVFGSAGGSQIPTANIQTVVNFIKKGLPVEEAIGAPRLHNQLLPAKTVLEYAGEFTRGYSNSTAQYLIDIGHNVTFTSPGGSTACALSRSEDGSYVAGPETRLFNSGGNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAQ0</accession>
    <name>I4YAQ0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959028.1">
        <property type="nucleotide sequence ID" value="XM_006958966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAQ0"/>
    <dbReference type="STRING" id="671144.I4YAQ0"/>
    <dbReference type="GeneID" id="18475586"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69463"/>
    <dbReference type="eggNOG" id="ENOG502S6HU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014992_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAQ0"/>
    <dbReference type="OMA" id="IMPSPLQ"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="723" mass="80162" checksum="09523CC2C78FE6FB" modified="2012-09-05" version="1">MSFNRLALAAALLEYDGSNKAKDSALFAPAPLTAEDGINKYAKFDSEIGELSDRVKRTSLSSDNSIPATKKIDIAKSVEAYRAGFDMSYPTQQKVEDRPDIPKDDINLDSWGLDGFLVKSSSADLPPPPPLRPTPGEARASKNRTLSDAAKLSDITAVAYHTSPQREQTRDDSSLANDSLFRDTSAVDLAKEAQNSTDSAKPTRGRAQSSLGFYREANSDFTLPPFDFTSKFDPKNAHHAKPEESQPTDVNNNDIPPHLRPSEPKHEEVKTVSRSTLLRPKTLVMPVPLQGSIDDINVHRDDQDLHHLPTELGLPLPLALKRARAHKRHTALAMNRASLAVPLNGKSDQGVSFTNRNSRASVFAPTAASSHAQGPYVGSSAGLPIAQTEGEQAQLYDEKLEDEYDKYIVRARKMREMEMSEMQPGTIFGSSLMDDIDARKQAQKDKRRVFRGDEHLQMMTPDGRSSITNATTRMQSVFGVDEHWQRELAKAEAIEAAERADAERNQRIEAERQERKHMKKNKKKSIMGLKSTGSKQSVEQNSSLNLPATNKENAAHSKNGIEDAEITLPSQAVASPVPNETLVGGRSWYDESVDSGSTGLPSARQSHEFDPKQFARPKRNNEWRHAPRKSIVPSSSRAPDGSLPPVELLQPSHSSINDSEDDYEDGRPISAIIRSRSQDAELHAQLEAEDDDSEDERPLSSFSFQEMLRRMHKRKMTMTYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAX3</accession>
    <name>I4YAX3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_38851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958792.1">
        <property type="nucleotide sequence ID" value="XM_006958730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAX3"/>
    <dbReference type="FunCoup" id="I4YAX3">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAX3"/>
    <dbReference type="GeneID" id="18472085"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38851"/>
    <dbReference type="eggNOG" id="KOG2411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_4_0_1"/>
    <dbReference type="InParanoid" id="I4YAX3"/>
    <dbReference type="OMA" id="DWPLLEW"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00777">
        <property type="entry name" value="AspRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047090">
        <property type="entry name" value="AspRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="147"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="580" mass="64956" checksum="7FD5BC0A1C5A452B" modified="2012-09-05" version="1">MAFRAIARTHHCNQLRVSNAGESVALAGWVQTPRRASNKLSFVPLKDFTGTTQLVVRSSSALEGLDKLPSQSVVLIEGQVNKRSDKQINKSLDTGEIEVDVKSYTLLNQATNLPFNPHDESIKEDLRLQYRYLDLRRKFLTDNLRKRSAVTHTIRNYLHDRHFTEVETPILLKSTPEGAREFLVPTRNHVKAPTFYALPQSPQQPKQLLIASGATDAYFQIAKCFRDEDGRKDRQPEFTQLDIELGFVSGAASQDAATSGWNMGGEQVRNLIEGLIRQLWREYQRTELESTFKVMKYRDAMNKYGSDKPDLRFGLEIALASMSADGNSQTRGLVYRPSRDGRLDGDFLKNHPGCSQITEEQKCNLDVQEGDIVWLEELPTNPEGGGTGLGALRLKLGEQLGLLSNPDAYAFVWIVEFPLFTRADEDKEFLSKGRWSSTHHPFTAPYAEDISLLKENVSLVRGQHYDLVLNGVELGGGSVRIHDANLQLKVFKDVLELTDDEVDRFDHLLVALKSGAPPHAGIALGLDRLVAIMCNTSSIRDVIAFPKSLNGMDRLFKSPSGTTDDILKEYNLEAKKVATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB25</accession>
    <name>I4YB25_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958840.1">
        <property type="nucleotide sequence ID" value="XM_006958778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB25"/>
    <dbReference type="FunCoup" id="I4YB25">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB25"/>
    <dbReference type="GeneID" id="18472947"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57744"/>
    <dbReference type="eggNOG" id="ENOG502RWV1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1391214_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB25"/>
    <dbReference type="OMA" id="KYASAEP"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="196" mass="21885" checksum="6C3D56D942FC2BB3" modified="2012-09-05" version="1">MTTTPRSTPVVSAAGIVDREDGERAIPQSVRADGSVRKERKVRPGFQPVEDIQRYKPPQSRYRSPGSLPSSPRQLDKNTIAGQQETDKKTIIQGLESLISENKPEKKTEKKTEKKDDAILQQPADTDIIAQKDKQDTTKEEDELTSKLADMQLGSMASVYATADPNERVEEQPQVHRGRGRGRSRGRPRGTRGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB67</accession>
    <name>I4YB67_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_29123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958881.1">
        <property type="nucleotide sequence ID" value="XM_006958819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB67"/>
    <dbReference type="GeneID" id="18471077"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29123"/>
    <dbReference type="eggNOG" id="ENOG502SF0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061593_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB67"/>
    <dbReference type="OMA" id="RSGWINY"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="238" mass="27121" checksum="D48689D823D6E927" modified="2012-09-05" version="1">MSYEDDNHLGAQVLPVANLPSDFSGDVEDGAQYLFTVRREASTIPNHKRVDNPYEVVCNTSTEKGKQRDTSDIQEPSREWRISFTANFKNLRKQLNSVNVPPLSELPEGYMPFPGKKDKGGWLNYINELNREPKLSIMKSLTMISALTLMTFLLENAKEGGILADRQTRWIIYLIASREEDYSGELVSELRVIARSVAGIIQDNDKESDKKNLWMVLTAIVGGFNQYDLYTDFTNNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBE8</accession>
    <name>I4YBE8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958643.1">
        <property type="nucleotide sequence ID" value="XM_006958581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBE8"/>
    <dbReference type="STRING" id="671144.I4YBE8"/>
    <dbReference type="GeneID" id="18471551"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32739"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="I4YBE8"/>
    <dbReference type="OMA" id="DAVFPGM"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="277" mass="29350" checksum="C8D571F9A8988FD8" modified="2012-09-05" version="1">MSDKRATLQLQELYSVKDAICVVTGGASGLGLTISQTLVQNLAKKLYITSRNVNQLKEAQKYLQSLNNNCVVECIPSNLSTKSGVDTVVDYVKARENQLDILVNNSGVTWGAKLEDFPEQAGFDNVMALNVKASFYMIAGLASLLAEGKTNTAPAHVVNISSIAGLATTAQNGGLTGGGVGVWSYNASKAALNSLTKTLAQTLSRRNIMVNAILPGVFETRMTRYGLDKYKDKILSSQPTGRYGEGPDLAATLLFLVSKGSAHVTGNLIVLDGGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBG5</accession>
    <name>I4YBG5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="10"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958659.1">
        <property type="nucleotide sequence ID" value="XM_006958597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBG5"/>
    <dbReference type="FunCoup" id="I4YBG5">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBG5"/>
    <dbReference type="GeneID" id="18471553"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32747"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBG5"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="226" mass="24208" checksum="22F43BA394F3355A" modified="2012-09-05" version="1">MCSAKSNVDLISNLRASKLISSDAVVAAMKKVDRANYVRIKSAAYEDSPQSIGYSATISAPHMHAHATENLLDYLKPGSKVLDVGSGSGYSCAVFHHLVGPTGKVVGVDHIDKLVELSEYNLKNDGLGDMLDSGAIKMVTGDGRQGYADSGPYDAIHVGAAAPSMPTALVQQLAQPGRMFVPVEKKSGNGQSIWQVDKDDNGALHYEELISVMYVPLTDRKQQIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBG7</accession>
    <name>I4YBG7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958661.1">
        <property type="nucleotide sequence ID" value="XM_006958599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBG7"/>
    <dbReference type="FunCoup" id="I4YBG7">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBG7"/>
    <dbReference type="GeneID" id="18474001"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60518"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_11_3_1"/>
    <dbReference type="InParanoid" id="I4YBG7"/>
    <dbReference type="OMA" id="ISAKENY"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="38"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="444" mass="49457" checksum="FC02462F10A30A10" modified="2012-09-05" version="1">MAGLEKTLEKPLVSRSYRLTKTYLKVILDNPESRRIFQFLCLNFSYMFIQLVYGVYTNSLGLISDAIHIAFDNLAIAIGLFASIMATWKPDSDFTYGYGRVETLSGFANGVLLILISLFIIFESIERIINPPEMEVSQLMVVSLGGLFVNLFGMFAMGGHHHHHHGHGHCSHSHDHGQKHVHSPIQADTVHSYTNDESKPLKASAIMSHSHATEEPKSQDYGGLFGSAGSHGHDDEHAHHHEHSHTHTDHHKEHSHDHSHSHSHSHSHSHSHSHSHSHSNSHHSHNMRGVFLHILADTMGSVGVVISTLMIQYWGWTGFDPIASLFIAVLIIASVVPLVIDCSKILSLNVGEANEANIKKTLTDLLNIEGLDSYENARFWPQDDSTLLGALHIKIKSQNNTFDHAHRQTKKHSSVEKVVDKVEYKLLNGIPGLKDVAIQVEPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBH9</accession>
    <name>I4YBH9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958673.1">
        <property type="nucleotide sequence ID" value="XM_006958611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBH9"/>
    <dbReference type="FunCoup" id="I4YBH9">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBH9"/>
    <dbReference type="GeneID" id="18474006"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60527"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017390_2_1_1"/>
    <dbReference type="InParanoid" id="I4YBH9"/>
    <dbReference type="OMA" id="YGRDRCA"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="372"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="491" mass="54150" checksum="463C4E958475A89A" modified="2012-09-05" version="1">MELNSDNIPNNLDYQQFLLQPSLFLSPSPNQYLNPSQQLQHPGRNIYVGNLPSDATIDELLNLVKFGPLESIKLFPEKSYAFLAFLDATIAIQFYHDATTRKITLHGQELKFGWGKNSQIPTNVLLAVQQSNASRNVYIGAIDDTTTEESLAKDLSKFGPIDQIKIVRDKNIAFIHYLSIAVAIKVVNELPHDPKYATKRINYGKDRCAYIPRNQQQPSTQALRTAAAIAASSGYPYSMAGFSPSAAAAFLSSSTYDNYLNPQLSNNNLIGGVPLDNIGNRTVYLGNLSEETTAEELCNAIRGGILQSIRYLSDKHIAFVTFIDPTNALTFYQVASYQGITIHNRRLKIGWGKHSGPLPPQLALAVQNGATRNVYVGALTDMDTFNEQKIRADFEIFGQVEQVNSLREKGCTFVNFTNISNAIKAIEAVKNDDEYIKAGIKISYGKDRCGNPPRSLSNGVSGKSSQRPSPSPHSTPSFDTSPVFQDVTNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ5</accession>
    <name>I4YBJ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_69186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958685.1">
        <property type="nucleotide sequence ID" value="XM_006958623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ5"/>
    <dbReference type="STRING" id="671144.I4YBJ5"/>
    <dbReference type="GeneID" id="18475542"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69186"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426548_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBJ5"/>
    <dbReference type="OMA" id="WIYFAGL"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000425">
        <property type="entry name" value="PLAG1 like zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="605" mass="67038" checksum="8E7D7BF09B6730AC" modified="2012-09-05" version="1">MTGSSEEVTPSSTDSQSNSLFDNSSNNRNTNASTSYTSASDVARPELLRKRSNSLTKLAFLTHQKEQQFNIQKTADDFYTSDRSSPHSNKQKDDENLSEESYSTTSSNKTRRHTFSGNPTKPLFIDFTRPIVQPSIKNLVNQDQSPPTRVRASILRAEEEDHQFYHQNQPQQHHHHYQQPQSQHMRTLPSEPLPQMPAALPTPAYRKYHRPHGQGSEQPPDQIAPSSSSNTQLPLPSLQNWSLDYNAPSKKTLGKKRKVGSNNLPAIPMDASKSTTIVQNARMANHEQHTNAQALAASKQDFEYANSSIGKQDTSQNTSNASTSKGKVYTCQYCSKTFNRPSSLKIHTYSHTGERPFVCQVNGCNRSFSVASNLKRHAKVHNNNLNNGNISQQHNQVTNSNFNEVDSPPTKDSSPTLNSRAGSGDGQTSSGSGDSKQDSAVAGEYADAEDNSSSGNEKRNNLVPAENNEALDEEEVEDESVTLAKDVNNRKKNTITNNTPNLDRTAQLIDGKVKSTMGVPQTKEINHKRIVDALNQGRSISIDGKSLHLQQPNRSIDENGTIISSKFQNQDRQAFDHDDSSSSNEIYSSPNDEDTVKPPNKKVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBP3</accession>
    <name>I4YBP3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Guanine nucleotide binding protein, alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_7927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958572.1">
        <property type="nucleotide sequence ID" value="XM_006958510.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBP3"/>
    <dbReference type="FunCoup" id="I4YBP3">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBP3"/>
    <dbReference type="GeneID" id="18475831"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7927"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="I4YBP3"/>
    <dbReference type="OMA" id="FMAIQAM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40592" checksum="964D19236A32C34D" modified="2012-09-05" version="1" fragment="single">MGLCSSKQDKNGKQRSLEIDKQLEDDAKKMRRDCKILLLGSGESGKSTIVKQMKIIHQNGYSKEELIGFRLIVFKNVVDSAQSVVLALRKLSMEPISNTNQHYADYILGFRLDLEPGMTLNKELVNAIDSLWNDPIIPKLLDRSSEWYLMDSAPYFFQNVHRIGNQDYIPNENDVLRARIKTTGITETRFTMGQLSIHMFDVGGQRSERKKWIHCFEAVTSIIFCVAISEYDQTLLEESGQNRMQESLVLFESVINSRWFLRTSIILFMNKVDVFRVKITKVPLEKYFPEYSGGAELNKAAKYILWRFTQTNRARLSIYPHLTQATDTSNIRLVFAAVKETILQNALRDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC48</accession>
    <name>I4YC48_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_57579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958562.1">
        <property type="nucleotide sequence ID" value="XM_006958500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC48"/>
    <dbReference type="STRING" id="671144.I4YC48"/>
    <dbReference type="GeneID" id="18472927"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57579"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="I4YC48"/>
    <dbReference type="OMA" id="DHAHYAT"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="293" mass="31394" checksum="B77B13F9121AAFF7" modified="2012-09-05" version="1">MLTSRPEKKVEACRFENKIIDTKMLLDRFPLIMQSIQTSKMSSSVSGKVFLITGSASGIGLATAIALLSKGAFLGLCDTNKDGLTSFFRNLDEDERSRVITHVVDISNRSNIASFLQLTKEKFGRVDGIANVAGTPGHKLGHQKIWEIDDKEYNFIMDVNVRGIFNVLSEGLKPGFLQEPGSIVHIGSMFSERGFSKGSVFSASKHAGVGMIKSSAIEAGKRGIRVNMVLPGPIDTPMLRANEDSGAEGTAPAVPLERLGEAQEVANVVTFLLGDEAGYVTGATWDVDGGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCC1</accession>
    <name>I4YCC1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_57409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958308.1">
        <property type="nucleotide sequence ID" value="XM_006958246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCC1"/>
    <dbReference type="STRING" id="671144.I4YCC1"/>
    <dbReference type="GeneID" id="18472910"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57409"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562842_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCC1"/>
    <dbReference type="OMA" id="WETWPSS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="485" mass="56692" checksum="DF4DA9D58D6A3766" modified="2012-09-05" version="1" fragment="single">MANDQLREVLNKPKILKNDLKDNNLTIRNNFEKDFKLFLTNKSAVDNILDSVDRLDVSLNISNDFDKFNNNSSNIKEKINSNLHLLNNYQDLDKLLNLNKELNLHLNNNNYKDFLHLLDSFKSITIETELSKKLSTDINSTKIKFKNKLLRNLKLDKRLNELNKQIKYLNLVFGIDYHQLSIIYLKSRLFYYVEYINNYNNNNIELLINNYFDFTRQFLLDLISQFQSIFTFNQTNILTFLPFIKHVFTILFNLINKNFNKIDNYLALSSISGTLTYINQSFSLIGLDISSFISTLIENSIINLLSISFTQSTGILTNKLQESLKSKTPLSNLLINDITQRKLLSNKHLNYKRLTQFSFEPPQDLTNHPLLANWLNSFINDLNSLRLFAPISIKYTLLKSLDDSLISIARIFSVLLIHNPINNQPADINLKSLYFSIYAFIYQILPYSRNALMKGIYDHDIIPPVNQELQSIIDRLVNWLDKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCZ1</accession>
    <name>I4YCZ1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA-dependent acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958135.1">
        <property type="nucleotide sequence ID" value="XM_006958073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCZ1"/>
    <dbReference type="STRING" id="671144.I4YCZ1"/>
    <dbReference type="GeneID" id="18472900"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57316"/>
    <dbReference type="eggNOG" id="ENOG502SGIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460197_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCZ1"/>
    <dbReference type="OMA" id="RPPMSCG"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66529" checksum="689FAF61C73CF8FC" modified="2012-09-05" version="1">MTQPLTNSSPQLFPSTSIIESFMDDRVISSLAHLAPSHLQWTDHNGVLTRPLGLVEMFFHKMALMHQGRTDIFFRLPMRIEGDDSWFDKLPIAWARLNQLHPSLSYAVIEDGSDEPMFSFDPTDLSGEPAHVVRNCSQTIIVERNFKDDVVEWMREQIWNGDRQFLNQSSNLGRLIVLHNSTTGEVDIIMAVAHCISDGTSVAALANEFLEILTGNELDGVNGSTVKIPTLSDYREFKPQLVNEGSLNSVTNFLNLTKEDIVSALPLAMESAYPPMPLTTRPPTLPRLRWYWAIRRVIAQVRGNILNRLSTVDFVGERSPSEQKELEPSWGAITNWKHFTLSPDQTNGVMRYAKECNVKIGSLLFATSSIVISNLNHIKQIDNGDTCLIGFPFSIRPYLDQTPNKARSTPLDVPSIMEISPLSVQLGFGGIQLPSTPCLVDSETFKIRFKSRAQSAQSQFRNLLSSATLLHDGHCMAMARARTFSEGHDGWKIVKQTESNSQLRGKGTAINGSMLGSMDKILKPSYTAKTYTLSLDNQRQAYIGVRCRTQEVLLETFTLNGQLTISLGYDRVLWPDESVDAYLEEFKRILLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDA1</accession>
    <name>I4YDA1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_54192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957755.1">
        <property type="nucleotide sequence ID" value="XM_006957693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDA1"/>
    <dbReference type="FunCoup" id="I4YDA1">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDA1"/>
    <dbReference type="GeneID" id="18472652"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54192"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDA1"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="38776" checksum="228846CDD1DD8197" modified="2012-09-05" version="1">MTIVRLATCVSGVYACFLLWALVQEKLSTTAYTNGENDDVYFRSSLFLNTVQSLASALSAFVYLNVRRTPGQSIKQLLAFNGGKTKYMLTGIVRVAVLQAIAQVLGFTSLKHISYPTMVLAKSCKLVPVMLMNVLIYRKKFAPYKYAVVLLVTIGISMFTLLKKSSKASTQTDSSFGLSLLFANLIIDGLINSSQDAIFQNHSINGTQMMFWMNLASSAVTSTAMIVGLPAIPLLGKTDSTSPEIYSAIHFVKAHPEVLKDIGMYAGCGALGQLFIFETLQHFGSLALVTITLTRKLFTILLSVFIYNHKLSSGQWAGAATVFAGISVEAAVKRKEVLDKRVFEEKKRSELKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB4</accession>
    <name>I4YDB4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957768.1">
        <property type="nucleotide sequence ID" value="XM_006957706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB4"/>
    <dbReference type="FunCoup" id="I4YDB4">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDB4"/>
    <dbReference type="GeneID" id="18473745"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60107"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_1_4_1"/>
    <dbReference type="InParanoid" id="I4YDB4"/>
    <dbReference type="OMA" id="WQWFTRR"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28719" checksum="10AEAE66CAAB4C1C" modified="2012-09-05" version="1">MVKQHLHYNKQNKQMLMRNLVSQLFHNEQITTTLPKAKEAQKFADRLITKGKNNTSKSDSLANSFLITSLTQDPFNKLKNQLVDRYKDRQGGYTRLHLLGNRQGDNAPRAVLELVDNPRDIKREVLMRTIARESLLRKTSWSPEKSNILRQLTQINLSKSLRYLSQEEKDTFHQKVLDIQDRILAESQLGLRRFDSDRKPQSNTLTWPSKGKTVYAGERTSGMAKSEGSPISLSKGVFRKSRKGPSNKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB6</accession>
    <name>I4YDB6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_37386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957770.1">
        <property type="nucleotide sequence ID" value="XM_006957708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB6"/>
    <dbReference type="STRING" id="671144.I4YDB6"/>
    <dbReference type="GeneID" id="18472011"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37386"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014832_3_3_1"/>
    <dbReference type="InParanoid" id="I4YDB6"/>
    <dbReference type="OMA" id="ADHVQIT"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="66"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="271" mass="30824" checksum="275E72C958D2E88F" modified="2012-09-05" version="1">MTSEAQSTELNDTEILELTEKIKEEESRGSPLIGVLEEMPALLKEYENGNEIYKNKINNLITEGYNHFRRIRGDGNCFYRAITYAFIELVSKDSQAATSAKERLENVGIPLLSELGFDSDIMLDFYQPLLSILDNVKDPSISIGDYLKVTLNDDEEVSNSIVVFMRYLTSATIRKNADDFIPFLFAYEGDLQLDDEGMPDIKKFCETYVEAFGKEADHLQMTALGRVLDLGLKVCYLDASERPTVDWHTLNENSKTITLLYRPGHVDLVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDF5</accession>
    <name>I4YDF5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_57113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Cytoplasmic vesicle</location>
            <location evidence="6 7">COPI-coated vesicle membrane</location>
            <topology evidence="6 7">Peripheral membrane protein</topology>
            <orientation evidence="6 7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Golgi apparatus membrane</location>
            <topology evidence="6 7">Peripheral membrane protein</topology>
            <orientation evidence="6 7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957806.1">
        <property type="nucleotide sequence ID" value="XM_006957744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDF5"/>
    <dbReference type="STRING" id="671144.I4YDF5"/>
    <dbReference type="GeneID" id="18472880"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57113"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076799_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDF5"/>
    <dbReference type="OMA" id="NQRYIYT"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27460" checksum="4120F085A8F8EDE4" modified="2012-09-05" version="1">MTILSAAICTKSGTPLISRQYKQLTRTRVEGLLNTFPKLIPTNSQNTTVETEAIRFLYQPINDLYLVLITNKGSNILQDIETLNLFNRITIDIIKQFDQEIILNHAFDLLIAWDEIIELGYRDNNNFNQIKLLLEMDSHEEKIQEIIAKNKEMEAKEELKRRARQLELQRREAARVGQSTGLSMGKYSSSSEINMSSTPSIEQTSPIQQQQPSQSRSQSHSFKGTGMKLGGKKKNTLDVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP3</accession>
    <name>I4YDP3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_32246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957889.1">
        <property type="nucleotide sequence ID" value="XM_006957827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP3"/>
    <dbReference type="FunCoup" id="I4YDP3">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDP3"/>
    <dbReference type="GeneID" id="18471447"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32246"/>
    <dbReference type="eggNOG" id="KOG0114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_25_2_1"/>
    <dbReference type="InParanoid" id="I4YDP3"/>
    <dbReference type="OMA" id="HQPDKMV"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="118" mass="13520" checksum="F1704FE06098BC2B" modified="2012-09-05" version="1">MSSGTKLGQDVNRILYIKNLPYSITGEDLYDLFGKYGAIRQIRLGNTKETRGTAYVVYEIVNDSKQAFDNLNGFHLNERYIVVMYHQPEKQAQIAMKQAELAKREEELAAFKRANDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP9</accession>
    <name>I4YDP9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Viral life cycle-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_17470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957740.1">
        <property type="nucleotide sequence ID" value="XM_006957678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP9"/>
    <dbReference type="FunCoup" id="I4YDP9">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDP9"/>
    <dbReference type="GeneID" id="18470733"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17470"/>
    <dbReference type="eggNOG" id="ENOG502QVHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDP9"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="493"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="758" mass="86193" checksum="455630BB194242E6" modified="2012-09-05" version="1" fragment="single">FLNERKLIKSAPLSALSDTRLGIDVQTYLNKLFLDFSTKEPMVAAMGGHPLALISHIESDLRFLEKSHIKPVFIFNGLHPSKKLKSQHNDQRSFIRSDAWSAYEQGRIQDAINSFGQRQNLFQPDLLRLIHKLFRQRHVEFLTAPYLSWPQLVYLLSHPKSYIHAIFGSTEHLLYPQVDKLITSLDLQGGTFNFVQKRSLLQDIKLSQEQFFDLGLLAGIDICPTFPPASYNFDFKQLIETVRHAKSGWFAVQNFVQSQQSNGHESSHYVESFQKAVILLKFSLILAAEEGRVLPLPLAIPPPPPQPALSSADIPSDLGDVFSPRLPDEVYFHLCRGLVGPWAINTLAQGGFQELPPLCNGETQDYKNFVKDYITESNFGPRAVAIALIASTLHPFWRNRQVHAHYYFHSHSTLVPHNSSTTTDLIKRIDHWNVPANVIEDELRRQNSSTIDFALCLGATSIDKSAERTITAKNTNGPVLHKKDEIVANTIWRFLELRSLLTPQHTHTPFGRAMHNALTVSRLNDKFQEPLLILVELLRAKVLHDRHFSNRQFSGGPSFGTEEEKKSMLLIIRTLSIVPLQFKPEQWSGPLSKELLVFNSFQKTLSRSLRTLVESISMNAFLKNNARRAREDYLDIALSLPFQNDINTGFGIFFKIYLDALTTFAEGSITEENKDSENVKEAKQSAKEILGEAIPNVRDAEAELMRGFRFWDAVSSFLSLYDRLMFFRYSSAFVHSKQIKPLISSWLNHSKQLIATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ1</accession>
    <name>I4YDZ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_17525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957742.1">
        <property type="nucleotide sequence ID" value="XM_006957680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ1"/>
    <dbReference type="FunCoup" id="I4YDZ1">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDZ1"/>
    <dbReference type="GeneID" id="18470735"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17525"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_2_1"/>
    <dbReference type="InParanoid" id="I4YDZ1"/>
    <dbReference type="OMA" id="AMKYNCE"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="102" mass="11581" checksum="4AC73D0CF0B5B41D" modified="2012-09-05" version="1" fragment="single">LQTLTGKTITLDVESQDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKVLASKYNCEKQICRKVCILYTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE99</accession>
    <name>I4YE99_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_17178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957480.1">
        <property type="nucleotide sequence ID" value="XM_006957418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE99"/>
    <dbReference type="FunCoup" id="I4YE99">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE99"/>
    <dbReference type="GeneID" id="18470725"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17178"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_2_2_1"/>
    <dbReference type="InParanoid" id="I4YE99"/>
    <dbReference type="OMA" id="ILAIPHC"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="26174" checksum="5FC5503D9A48540A" modified="2012-09-05" version="1">MSESDKLEIGTSDDIKKSKPGMIYITRIPPGMTPSKVRAIMAQHGELGRIYLAPACRLTNSHPKNPRFVEGWVEFKKRKIARKVAELLNAQPIGGKKGDRYREDIWTMKYLGGFKWEMLSEHIALEQASHAAKLRNELSQSKRDQEDYLKRVDKAKKQQAIEERRQAKGLSAKQETKQYEFKQRQVLSQDMKPETNPSINAKRKRAGYDDAAEQQKSKKLDSVLGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH5</accession>
    <name>I4YEH5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957621.1">
        <property type="nucleotide sequence ID" value="XM_006957559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH5"/>
    <dbReference type="GeneID" id="18473702"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60039"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676530_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEH5"/>
    <dbReference type="OMA" id="NMNHASV"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="3">
        <location>
            <begin position="254"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="420" mass="46588" checksum="F8BF1FB9515E48EA" modified="2012-09-05" version="1">MTIAELVHSDPRYFYPAKITIKHPQLRDLVHTSDSCSVYYPHNRSIIKHYLDAPGKPRVKSQLSYPPVTLSTGYGMLASAGGSGEVTIQSLDDNDSGGGFYETRFGSSINNHIAFAPEATSSIEPRLLVCSNDNIIRVFKVAYSRLEHQTPQLYQTETLKFNTAINQASISPNSRICVAVGDTPEVHLFDCGSSGSFRRMQTLTSTSDAGFSTAWSSDGLKFAVSSQDGFCTVWDIRSNKPLEKFTTCNQMPSRAVKFTTNAASKELMVFTEHSNRIHVVDALTFSPSTKQVLEIPFTDSNTTPPFLSPRSESPSPTSPAMQPSIYDEDYSSAPELFSTFFPSNSNPTRSLRQLFNSTYANLDRLTPSVIERERYIGDVDIAGITFSSDNSRLYAGSMRNLIEWDIYGAYSKLFETGEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV1</accession>
    <name>I4YEV1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957733.1">
        <property type="nucleotide sequence ID" value="XM_006957671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV1"/>
    <dbReference type="STRING" id="671144.I4YEV1"/>
    <dbReference type="GeneID" id="18473739"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60097"/>
    <dbReference type="HOGENOM" id="CLU_991113_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEV1"/>
    <dbReference type="OrthoDB" id="4670611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697745" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31453" checksum="04D2F593FCC37516" modified="2012-09-05" version="1">MFNRILLVSTALTSAVVNATTYATFYSDSDCTENASVDFSVNDAGCFSVGSNEYVKYHGANAQCFSLVKSPSPSCPCQFDCITGFNSIGSTIDTCGFTIIPDNKCYHIGQSESLRFIGGSCGTSNCPDRSSRSIPALKDYSEDIEEVVEDEEEPTSEEAEEGLTNESAAELVNTYGNATSPSLDRRDYGKPGAGYFRFCKDEYCTLDCSINFRTTNTGCIAGDGFKSIQFFDSVLSETNLRLVHTPHGECSCQDDCWHVVGNECMVLPKAQQGAGSYRMTTEHSCASNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV4</accession>
    <name>I4YEV4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_37354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957735.1">
        <property type="nucleotide sequence ID" value="XM_006957673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV4"/>
    <dbReference type="GeneID" id="18472010"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37354"/>
    <dbReference type="eggNOG" id="ENOG502QPTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEV4"/>
    <dbReference type="OMA" id="EDDWLRE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="159"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="407" mass="46226" checksum="56D4C79699AD46F6" modified="2012-09-05" version="1">MLINNYFFSSNESFSYEALRAAGYSNYGGADLGEVIAICSQIRPGNEDDWVREWQKAAQRAYGYADHSKVVNNKASAYEGYLRASNYFRTAEFFRRENVDRDETSNFLYEKSENAFLEAMELSPFTYESINIPYEATTLPGYFVSLDGTKKARRTIIFNGGYDSTRSEGWFAIGAAALARGYNFLAFDGPGQGAAIRRQHLYFRPDWENVLTPVVDYALTRADIDASGIVLFGWSMGGYLVARGATQEHRARAIILDDGVYDFGSAFRAKQPLFVQKLVQLKYDSICNLIFRGVQAFSTNASWGMRNGKWTFGVSSEAELMRAVNDYTLEGRCENIRTPCLILDAENDHFLKGQPEMLRKHLQCEHELVSLRADEGGDKHCHHGTFFRLHQVLFDYLESQLALDERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEY3</accession>
    <name>I4YEY3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DEAD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_44125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957197.1">
        <property type="nucleotide sequence ID" value="XM_006957135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEY3"/>
    <dbReference type="FunCoup" id="I4YEY3">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEY3"/>
    <dbReference type="GeneID" id="18472320"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44125"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEY3"/>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="67"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="319"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="509" mass="56790" checksum="A410BED1CBE62B73" modified="2012-09-05" version="1">MEEEVGINVRTGLLSRVNKKLNKNTTIKEPTKSSASTFADYGVHPSLCNALKSLNITTPTEIQKSCMAEIMNGRDCIASAKTGSGKTIAFGLPILQHLTKDPYGICAIILTPTRELAFQIADQFHALGGHLNLRAPVVVGGMDMMEQAIELQRRPHVVIATPGRFADLLKSKGEEWNLNKVKYLVLDEADRLLSTTFAPELSEIFSHLPTKRQTLLFTATATPAIISLKDKKPAEGKQPPFVHLLQDDHSTPESLQQLYVHVPSHVRDVYLHHLLINPPEIVEDQRHTPPDLSNPVSKSAFDEQSKKRKRKEKVLSEEDLEILAFQPVPTIIFTARCQTAAQLTTELQQMKVRCAPLHSYLNQAERLHSLSLFRGGVIPVLVATDVGSRGLDIPEVALVVNYDLPRDPNDYIHRVGRTARAGRIGVSVSFVAERDVDLVEAIEKHTGVTMEEHSMNENKVLENMNKVFTARRVANLALHDSKFGEKQKINKAKNKKRRKYEKEFLEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF42</accession>
    <name>I4YF42_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_63222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957254.1">
        <property type="nucleotide sequence ID" value="XM_006957192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF42"/>
    <dbReference type="FunCoup" id="I4YF42">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF42"/>
    <dbReference type="GeneID" id="18474821"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63222"/>
    <dbReference type="eggNOG" id="KOG3487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085828_3_0_1"/>
    <dbReference type="InParanoid" id="I4YF42"/>
    <dbReference type="OMA" id="HEAKNDE"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="177" mass="20047" checksum="BDE6047662CBF0B6" modified="2012-09-05" version="1">MAAIYHLYLLNHEDTPIFKDTYTSTRFTTSAEPLSSPANAASPTFNDMISALVGTHNRRTSLPMNGEQGGEFHQDVMDLVAHASLDVIEDVQSKSNNMYHKCVDKFNGWSISAFVTPSSTRFVLLHQVKNDDNIRLFFQECWEAYLKTLLNPFYTSTDAIRAPGFQDKLVKSARKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFC1</accession>
    <name>I4YFC1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957328.1">
        <property type="nucleotide sequence ID" value="XM_006957266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFC1"/>
    <dbReference type="STRING" id="671144.I4YFC1"/>
    <dbReference type="GeneID" id="18473602"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59878"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFC1"/>
    <dbReference type="OMA" id="YRQIDPF"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="50"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="31309" checksum="928168E7D41E422E" modified="2012-09-05" version="1">MHDDNELVRFLQARKWDIDASEKMFRNYLQWRKDFNIDELSESFELTKDEKAALDQYYPQFFHKTDKLGRPLYYQQFNKLDASALFEKITPERFTLNQVISNERLVKDTFRACSKARGLHVSQTVNIMDVKGIAYYQFWKIRGRFQSIIQILQDNYPELSGPIVIINAPTGFSTIWKVVKAMMDQATASKVSIHGSGYKEALKELSFDENLPTEFGGSCVCSLHADEKELYENGTSKDKPSTCAIKGPRPTLDEVSNGNFENIGVINKDDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFM8</accession>
    <name>I4YFM8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957427.1">
        <property type="nucleotide sequence ID" value="XM_006957365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFM8"/>
    <dbReference type="STRING" id="671144.I4YFM8"/>
    <dbReference type="GeneID" id="18473635"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59933"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014280_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFM8"/>
    <dbReference type="OMA" id="FGQWTIT"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="591" mass="66995" checksum="769C9FD71658BF7E" modified="2012-09-05" version="1">MDNPSDEESYREEFSEAEESEIDFTDMDDVTGRREAQELLDEMIIQEPNDEELENTERSARLSILQMLLSNARAGGDRRVYVVDNDEDDDDYMWYPRMRRDRYTPTPSTVQDEGVKLTKSGMFGYIPKYTSLQKAIKDRTATFNRFRPSYLGLIPNSSGTVVARSSAPVYSGEYSNDGQLFYTADRNFNINIYKPNEPLRSAHSGMENIDNNYSEEHATTMSHLSRITGNYSGWTITDSHLSTDNQWLIYSRISPTAHLVKLGDPDNRQIPLSFSDDGMGDYGYGYGIWSLRFSSDCREIVAGAADGTMYVYDVEARKRTLALDGHNEDTNAVCFADVTSNICLSGSDDCVAKVWDRRALSRNAKPSGVLVGHTEGITYVSPKGDARHILTNSKDSTIRIWDLRKMISSDDYDDTAKVAPPEQFSIPGYDYRSAFVPKPEYDKHPQDHSLVTLRGHLVSRTLIRARFSPDSLTGGRYVYSGSADGKIYIWSISGELIQVIDRKLAMDMENHESRKYNDPSAPEYSSGSSRSGNHNRRPIIRDVSWSPTDCNLMSSAWEWDESGSVARHDWKELNKMNYSLESWVEKLDSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ8</accession>
    <name>I4YFZ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956939.1">
        <property type="nucleotide sequence ID" value="XM_006956877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ8"/>
    <dbReference type="FunCoup" id="I4YFZ8">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFZ8"/>
    <dbReference type="GeneID" id="18473488"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59669"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="I4YFZ8"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="560" mass="60781" checksum="14B22470376023FE" modified="2012-09-05" version="1">MAQAMGMGPGGQPVMVMNTAGPERQSGRKAQISNITAAKTVSDIIRTCLGPQSMLKMILDPMGGILLTNDGHAILREIDVAHPAAKSMIELSRTQDEEVGDGTTSVIILAGEILAQSSGLLEKNIHPVQIIQSYKLALAEALKTIESIGQPLNIDDEKEMLALIKTSIGTKFVQRWSELMCKLALDSVKIVATSAKDSANNDIKSVDLKRYARIEKVPGGDVEDSQVLSGLMVNKDVTHPKMRRKIDNPRVILLDCPLEYKKGESQTNIEISKEGDWEKILAIEEEQIKQMCDHILQFKPDLVLTEKGVSDLAQHYLVKSNVTALRRLRKTDNNRIARATGATIVNRVEDLRENDVGTKCGKFEVKKLGDEYFSFLTECVDPKACTILLRGPSKDILNEIERNLQDAMSVARNVVFNPLLAPGGGATEMAISVALNTLAKSVQGVGSLAVKAVSEAMEVIPRTLVQNCGGNTIRTLTELRARHNNGLVSHGIDGDLGKVVDMKEYGLYESAAVKIQTIKTAIESASLLLRVDDVVSARRLEQAGGAGMMPPGEMAEGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGC7</accession>
    <name>I4YGC7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957058.1">
        <property type="nucleotide sequence ID" value="XM_006956996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGC7"/>
    <dbReference type="GeneID" id="18475314"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67894"/>
    <dbReference type="HOGENOM" id="CLU_1103501_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGC7"/>
    <dbReference type="OMA" id="KANVAHE"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="252" mass="27858" checksum="181C98B12BF101F4" modified="2012-09-05" version="1">MSETTQPANQPQEIAEKVAPAQTSEQVPPKVDTSSSATKNAEPTTAAEPVAQSPASIQNTPTEAKPQNAADRAVNGEQAETAPSPTGRGADRVSNDHPERLQNADAQLQNEDRRTILMNEGKDAKQIAKILESEAKNDASALKNALKDAEKAHKMSAKADKSITQANSRLEKAIKNHHDIAKKLERLKSDHEAAERQREQMHKELELKKQHKAEIDALVDERMERVEKLKNGKAILDRERTVQRRSTINPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE2</accession>
    <name>I4YGE2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_53811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957071.1">
        <property type="nucleotide sequence ID" value="XM_006957009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE2"/>
    <dbReference type="FunCoup" id="I4YGE2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGE2"/>
    <dbReference type="GeneID" id="18472632"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53811"/>
    <dbReference type="eggNOG" id="KOG4035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017272_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGE2"/>
    <dbReference type="OMA" id="ELHEYGH"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="1">
        <location>
            <begin position="205"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="419" mass="49039" checksum="11029FBA5C27DCA5" modified="2012-09-05" version="1">MTADDEDFIVWEITDAHDFWNELSEYGHAPDDVTVLELDGRLKMFLRLCGQYHTRYLTDSLQFRTALELMVNSDLFRFHYVRMERVLIDFILITPDPHQLFVAYELLLRYGQSSDKFFKDCTSWRKLLPYWLDVIRNVQDGYFGEDDDGTGIAPIEIRLRYTVICLLYEISRAQKLSDEDLATFNSSFLDHLFDLVELTRDEADECFNYTIIKLLTSLNEQYMIRNLDSNSVRSQHLQISNNLVLNVLTRRLGTSKTFGENLIFILNRASDCREDICVKLLVLKILFLLFTTVGTENYFYTNDLKVLVDVFIRELADLPDEQEGLRHTYLRVLYPLLNKTVIKDADYKTLEVHSSLCALVNQTRLRDVSATTARLQLLRESTNAIELFNGVRSNDTQYGCSRKRLHDSEKRIASYTFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH14</accession>
    <name>I4YH14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_43294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956646.1">
        <property type="nucleotide sequence ID" value="XM_006956584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH14"/>
    <dbReference type="STRING" id="671144.I4YH14"/>
    <dbReference type="GeneID" id="18472279"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43294"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="InParanoid" id="I4YH14"/>
    <dbReference type="OMA" id="FYIRESF"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="47892" checksum="F2F52DEEAD9C9A17" modified="2012-09-05" version="1">MEVKDKFSWHSPLLLPASRMQISFLKDLATFRNPASSYTFVNYLHSHGVDRLAGFSNIGCWTPSRTEWAAYLTWAAARLSDVCEYSTRVLNVEAIKKGEKVEKLKVTSVHWPTETVHVRYTRNISIGVGAIPKIPEVFSTAQKSNMTVSHTCQYLPTLKYMFGHHEENVEFKGRFAVIGGGQSSAEVYNDLINRYPNAEVDLIYRASALVPADDSPFVNARAFDPASTEEFNKLTHKARKERLEEFKRANYSCVAPELLEGLYTLLYKQRVKADIAKDAGLPAPPNQYSIMPNSKIVGVKADEKCTSLDIQSTLDFEGQESPAPITKEYDAIFLGTGYERPPTQLEFLKDVAPYLPKLKNALSVAQLEPSAKVPPLVEREYYIAPESQELFKPRIFCLGQNEQSHGLSDSLLSVGAVRAGEVVSALSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH29</accession>
    <name>I4YH29_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rab GTPase SrgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_27385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956661.1">
        <property type="nucleotide sequence ID" value="XM_006956599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH29"/>
    <dbReference type="FunCoup" id="I4YH29">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH29"/>
    <dbReference type="GeneID" id="18470991"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27385"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="I4YH29"/>
    <dbReference type="OMA" id="ENIRTWF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="207" mass="23024" checksum="9973DBDF5CCB1388" modified="2012-09-05" version="1">MGNPHYDFLITINKPLVLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHSNVVQYASEGVNKILVGNKCDWDEKRAITQDQGKELADSLEIKFIETSAKNNVGVEDAFFTLARDIKSRLIDSQSSGSNNQSNSVKVDASQQQPSTSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH97</accession>
    <name>I4YH97_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_43392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956723.1">
        <property type="nucleotide sequence ID" value="XM_006956661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH97"/>
    <dbReference type="FunCoup" id="I4YH97">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH97"/>
    <dbReference type="GeneID" id="18472285"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43392"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="I4YH97"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="842" mass="93730" checksum="EAD34B179351BD8D" modified="2012-09-05" version="1">MVQFTIDELRGLMDKPTQIRNMSVIAHVDHGKSTLSDALVGKAGIIASNKAGDMRFMDTRDDEKERGITIKSTAISMYFPLPKEDMEALKQPSEGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCIEGVCVQTETVLRQSLIERIKPVVCINKVDRALLELQVGKEDLYQSFSRTIESVNVIIATYNDPVIGESQVYPEKGTVAFGSGLHGWAFTLRQFAGRYAKKFGVDKSKMMDKLWGDNYFNPKTKKWTNKDTDADGKTLDRAFNMFVLDPIFRLFDAIMNFKKDVVNTMVDKLEIPLTSDERELEGKPLLKVVMRKFLPAGDALLEMIVINLPSPKTAQRYRVEGLYEGPLDDESAIGIRDCDPKGPLMLYVSKMVPTSDKGRFYAFGRVFSGTVSSGPKIRIQGPNYIPGKKDDLFVKTIQRTVLMMGRNVEAIEDCPAGNLIGLVGVDQFLLKSGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVQTWIAETGEHIVAGAGELHLEICLNDLENDHAGVALKKSDPVVGYRETVKAESSMTALSKSQNKHNRLWVTAQPLEEELTRDIENGKLTPRDDPKTRARYLADTYGWDVADARKIWCFGPDTTGPNVMIDITKGVQYLNEIKDSCVAAFQWVTKEGVCTEENMRGVRFNILDVTLHTDAIHRGGGQIIPVTRRVCYAAHLLADPGLQEPMYSVEIQCPETCLGGIYSTLNRRRGMVYWEEQRPGTPMYTVKAYLPVLESFGFNGALRAATGGQAFPQAVFDHWELMNGSPLEKGSKLEALVKDVRKRKGLKEDVPPLENFYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHH0</accession>
    <name>I4YHH0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_62775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956789.1">
        <property type="nucleotide sequence ID" value="XM_006956727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHH0"/>
    <dbReference type="FunCoup" id="I4YHH0">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHH0"/>
    <dbReference type="GeneID" id="18474789"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62775"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="InParanoid" id="I4YHH0"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="108" mass="12526" checksum="C933A3E5F9F9846E" modified="2012-09-05" version="1">MDVVNIPKTRRTYCKGKQCRKHTPHKVTQYKKGKDSIYAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECSVCKYKMQLSLKRCKNFELGGEKKQKGAALNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHH7</accession>
    <name>I4YHH7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956795.1">
        <property type="nucleotide sequence ID" value="XM_006956733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHH7"/>
    <dbReference type="STRING" id="671144.I4YHH7"/>
    <dbReference type="GeneID" id="18473449"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59603"/>
    <dbReference type="eggNOG" id="ENOG502QUE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019790_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHH7"/>
    <dbReference type="OMA" id="CAQNDAL"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="433" mass="48133" checksum="CCBC9C3D512B2061" modified="2012-09-05" version="1">MSAIKAAPKKEITGKIYVQPSKNWEIPARPKPGRKPIEQDPPNRKSQNRVAQRAFRERKQEYVQELEQRLAAYEANAIERNVALQQVSQKLKQENDALKDENVVLKKRLQRYEDGSSIASGSSHDTSATQRAIKRKYRDMYESPNEIPQPEIAPSPIKLQNILQVDQLKVDDELDRFFSCGFCSEETPCVCRQVTTQESAPPAASILDNPPAYQPAQPLRKKRTSGKKLFQVQTECSGDPDNCMACQQDDSLACRDDKPGRAFFEALQGSVCTEGSPSQKCQGCPTHTPPGAGMEVDENGQSIPASDAWRRLKSHPNIGLADLALLADLVASRTSCTGAELHQQVEKVLENVPPEAEVKVDLARLQQQESNPQPSSLQRPSGQARRNSTSLQLPQLVPQEQLVSNSKRRRLLVEMGAVRDALDVLDRFSAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHM0</accession>
    <name>I4YHM0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956833.1">
        <property type="nucleotide sequence ID" value="XM_006956771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHM0"/>
    <dbReference type="FunCoup" id="I4YHM0">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHM0"/>
    <dbReference type="GeneID" id="18473460"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59623"/>
    <dbReference type="eggNOG" id="KOG0456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_4_1"/>
    <dbReference type="InParanoid" id="I4YHM0"/>
    <dbReference type="OMA" id="DNINIMM"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="495"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="561" mass="60079" checksum="927DF43D2DCEC22C" modified="2012-09-05" version="1">MSHTNQTSRNWIVQKFGGTSVGRALDSIVDQIIPQYFPTSNVVLVCSARSGTSKSTGTTNLLLKAATEALSSRSNGTPSQPGTPGFSALTRPRFGSPQPSRSASPPGVNHSHLDDSLRKLSLSRGSLDEPDFVLTTNILREEHFNAARVIIKNDEIRKRVEADISADIDSLCEFLNAAQIIDEISPRSKDAIVGLGERLACRLVCAALSDRGIPNELVSLEGVVDAFVDGGCSNNDNISLDQGFYTRLAQRLGERLRKCEGKVPVVTGFFGPVPGSLLQQVGRGYTDLCAALCAVGLNGGELQIWKEVDGIFTADPRKVVTARLVPIITPDEAAELTYYGSEVIHPFTMDQVIRASIPIRIKNVLNPLGPGTVIFPDTFNTSVNNPGEDATEAVNAKHAGHVSSKLPTAVTVKDNILVLNVHSNRKTMSHGFLAKIFTTLDKFGVCVDLISTSEVHVSMAIHGSNSSTKSFERLVKELESIGTVDVHHDMAILSLVGRAMKHAVGIAGKMFSVLAAGNVNIEMISQGASEINISCVVQEVDAIKAMNIIHQACINVNARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHX6</accession>
    <name>I4YHX6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_11260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956134.1">
        <property type="nucleotide sequence ID" value="XM_006956072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHX6"/>
    <dbReference type="GeneID" id="18470590"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_11260"/>
    <dbReference type="eggNOG" id="ENOG502S8TF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2043802_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHX6"/>
    <dbReference type="OMA" id="FMEEGCE"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="121" mass="13340" checksum="39FA7B9DA3C6A8D5" modified="2012-09-05" version="1" fragment="single">VPLQTPSRAPAHPSPLAEQPEFTKKKELLSAEQKRNNHLQCEQKRRSAQKAAFDALATIMADENPNLGATSSSSRSKTRSKSANTSKGVLLSKAVSLIRWLERTNAALKKEIDKWEQSAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHX9</accession>
    <name>I4YHX9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_42729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956246.1">
        <property type="nucleotide sequence ID" value="XM_006956184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHX9"/>
    <dbReference type="GeneID" id="18472262"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42729"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_2_1_1"/>
    <dbReference type="InParanoid" id="I4YHX9"/>
    <dbReference type="OMA" id="HLQQSFI"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="53462" checksum="B132587AACA4A2CD" modified="2012-09-05" version="1">MQGNLIGVTLALLGNIVIALGLNFQKLSHLQITSSEIESGTTFVNRTGDDEVLPAEDDDRATIKPTSDNSLKLLLLNLRDSVVKAIKNDAKYLKSGTFWIGLGLTTLGESSNFIAYGLSPAPLVAPLGSVALVANCLFSPLLLKEHFGLQEILGSSLCIIGAFVLIASNKNRDGQIDYEELLEGITHPTFQIYVVSLLIAIIGLISLSNKPIGQKSVTIDVSICALFGGLTVISTKALSSLLVHNFADAFRHKVAYLALSVLLITAAAQVHFLNKALNKFDSKIVIPIQYIFFTISVILGSSMLFKDIQTFPYLILLSGLTVSFCGVYFLSCAPQSDHFSNLSAGIEDGPQRNQSTDTTLTPLLGSAPERIRTSRSNSSFTKVGIGLSPARYLLASHSPNSTFRDDNAPIISNNNSQTYNGVNYGTTPRTTDLMNAYDLSQTPTPYSSGLADHFSNSQTSRLSPRSKASNLFGDPEDSEITPRQQHIPTFSTTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI02</accession>
    <name>I4YI02_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_3761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956130.1">
        <property type="nucleotide sequence ID" value="XM_006956068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI02"/>
    <dbReference type="FunCoup" id="I4YI02">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI02"/>
    <dbReference type="GeneID" id="18472025"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_3761"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_5_2_1"/>
    <dbReference type="InParanoid" id="I4YI02"/>
    <dbReference type="OMA" id="KSREEPF"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="84" mass="9265" checksum="834BCE112974E6A3" modified="2012-09-05" version="1" fragment="single">PLPLGYESPKDKAYRKFVEQPLVPIGIGATIIALTRAAMEIRRGNSRAANKFFRYRVYAQGATVVAAVGGMWYYGTAQEQKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI52</accession>
    <name>I4YI52_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maf/Ham1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_27126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="EIM23644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956312.1">
        <property type="nucleotide sequence ID" value="XM_006956250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI52"/>
    <dbReference type="FunCoup" id="I4YI52">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI52"/>
    <dbReference type="GeneID" id="18470978"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27126"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="InParanoid" id="I4YI52"/>
    <dbReference type="OMA" id="VIGCDSV"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="30985" checksum="304D4B86E942CCDC" modified="2012-09-05" version="1">MFSYFLSNNNNTKQEEEKPLKTLLDNPPAAAKKQILPFRLPSLDKLKDKHVILASASPRRLDILAQVGIHPRVIPSTFEETLSKDDYLHNPHAYPINTATEKGKEVYERLVLEDDKNSPDLVISADTVVLVPDDAPSLSKGQSYDEVINQPLTYSICEKPKDADDQYRMLADASGRELQVVTGVCITYPILQSPGYAQKTFANMTKVHFFDNDHDVIEKYIETGEGIDRAGGFALQGLGSLLIQGIEGDYNNVVGFPLSEFIRFLDTLIENDDGVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI62</accession>
    <name>I4YI62_WALMC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956322.1">
        <property type="nucleotide sequence ID" value="XM_006956260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI62"/>
    <dbReference type="GeneID" id="18475232"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67285"/>
    <dbReference type="HOGENOM" id="CLU_953783_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI62"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="292" mass="34067" checksum="5098DCE16784EE6B" modified="2012-09-05" version="1">MSIYSLLRDGEQFTETTSSSDYNSRIDTYSKATLVEIHSIVRSLENDLSLCLRDDYKQQSILNVKHYSDIVYTLAADFHNNINTIALENNKNNKEILNEITRFNARQMQFNMSLMSWLQTSQRVKELNNADLVNLVKSSRQFYALAIEQLYNTIDLSIYEDSRLVHAIINLIYSLNQSSNNSRHIRKLKLNYSSLNYQIIRKNLLQNLLELIPATTYTSDGRKRRFVLKIINTEPEDILHTDRIANLLTQIPQLETLVMVMKSSSKTLTVKRDQSSQIEEFYEFVRRSDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI91</accession>
    <name>I4YI91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956349.1">
        <property type="nucleotide sequence ID" value="XM_006956287.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI91"/>
    <dbReference type="GeneID" id="18473296"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59341"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_1_0_1"/>
    <dbReference type="InParanoid" id="I4YI91"/>
    <dbReference type="OMA" id="DIMGLCG"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="356"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1234"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1155"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1347" mass="151333" checksum="54BED7C0ABB2FF64" modified="2012-09-05" version="1">MDRRPPIKHHSSSSFKSSETLEGPTVSFHYQQNDIESGQNNSNFKRKKSLVKPERERLNQNHRLFHYRNSAANQSGHVDVKASSTGAYPQQSALRRGKSVLGREDPGPSLLRRQTKRQKSTSVDTPGNGPTGTEPVTAKPSKLSAYSSIPGPKGPWMLYCFIITCFIPNFALKLFGINTPERQRAWREKIGLIGVIACLMALVGFITFGFTQTVCGRPPNRYQVGHIDNGNLVINGYSYSLNTWDHPQVDDWFTDDEDRNVLFNGPMPAAGMDASFLFQRVNQDCLNVITPADGSGIDHSGNQMSWYFPCQLFSPNGTSSASLTNYTDPTLCHTSSTARDAYHSLDTVQDVTTGQIYFTWEDIRNPDRNLIVYEQDVLDLDLLNWLDSSQVNWPLEFDELKSPSPNDKYKGRDITMTMQRTGRDEIGKCLQNVIRVGFIDTDTIGCVASNVVLYLSLIFIIGVVSIKWAMAVFFGWFMSWRLGVGFKESREERHARMNAIENWTDDIHRPAPSKYRPSQLPLPSKMSALSKTTSKILPKSSRFTPAQEKPTFIPELNKRATNFTSSGTKSFLASSVYSPPDSPIIRGARSSSSLPFASSKEFVDWNRSSSLGSGSSGGCPYPLAVDAVPQPSSDYEPFNFPLAHTICLVTAYSESVEGLRTTLDSLATTDYPNSHKLLLIIADGVVKGSGNDLSTPDICLSMMKDLIVPRDQVEAHSYISIADGHKRHNMARVFSGFYDYDDASVEPSKQQRVPMILVAKVGNPLEASEAKPGNRGKRDSQVLLMAFLQKVMFDERMTTFEFEFFNNIWRVTGVCPDRYETCLMVDADTKVFPDSLTRMMACMVVDPEIMGLCGETKIANKAQTWVTMIQVFEYHISHHLAKAFESVFGGVTCLPGCFSMYRIKAPKGGQGYWVPVLCNPDIVEHYSENIVDTLHKKNLLLLGEDRFLTTLMLKTLPKRKMMFCPQAVCKTVVPDEFKVLLSQRRRWINSTVHNLFELVLVRDLCGTFCFSMQFVVFMEMVGTMVLPAAITFTIYIICLGIIPSQPTPTISLILLLIILGLPGLLIVLTSRRLAYVGWMLIYLLSLPIWNAILPAYSFWHFDDFSWGATRQIEGEKEGESHGDKEGEFDPSHIIMKRWNEFERDRRYKTGTNSRDSTDDFTRSPRRNDYRRSVVSNHDSGSTLDILRVPASPSRASLSGPPLIELPHPLSNEASNTSSPLAVPKIPSTLINDELNKSDVNDDSGLEQPFIRFNHENSPKRNESDSEKLSSIPSNNPYRHSQLEYNNLTSKPPVLDINLLDQGPVGESPRRLIKPTNKRNSPSSSLALDQLNHHNQQRRTERDEYDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE8</accession>
    <name>I4YIE8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">La-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_42953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956405.1">
        <property type="nucleotide sequence ID" value="XM_006956343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE8"/>
    <dbReference type="STRING" id="671144.I4YIE8"/>
    <dbReference type="GeneID" id="18472271"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42953"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035334_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIE8"/>
    <dbReference type="OMA" id="CEGLERC"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="102"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43290" checksum="2B577CE9650B86A4" modified="2012-09-05" version="1">MTSAVEETPEGQILKQVEFYFADTNLPFDKFLWSLTKKNPEGYVPIATISSFKRMREPVEKAGGVEKVAEILRQSDKLAVSEDGVNVKRVEQVKPVVDRESRSIYAKGFPDESENTQVELEKYFAAFGKINAVRLRRDEKKKFKNSVFVEFDNVDDAKRFLELPQEQRKYGETELLTMSKEAYVEMKCKEKGITPGSNNKKQGKGHFNAFKEENKKTRDAEKADRPLTMMLMGKEIEINKENGQFDESLLQFTSGSVLKWSSESSLGDMVFRDIKSSMKQHIEPSFVIVDDEKKSGMSGFKRKVEDEDINKLNENVKVNDVSVSFTRPTQEEENKYYLENAKNMAQAVLTRHREGGKPNNKRKGGNFQQGNKKQRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ1</accession>
    <name>I4YIJ1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956446.1">
        <property type="nucleotide sequence ID" value="XM_006956384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ1"/>
    <dbReference type="STRING" id="671144.I4YIJ1"/>
    <dbReference type="GeneID" id="18471274"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31271"/>
    <dbReference type="eggNOG" id="KOG0503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_2_1"/>
    <dbReference type="InParanoid" id="I4YIJ1"/>
    <dbReference type="OMA" id="AEVKLMY"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="4">
        <location>
            <begin position="234"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="331" mass="36856" checksum="88373E7AAA1F8F83" modified="2012-09-05" version="1">MANSIFSNLNNKQAYALWFDQEKPTQKQASIKEHRRTLTVKAHQEFHGSHFNALQTPKTFLSGVEHTVKYAILEYDPLLDSSDVSPKEWVKIVRDIELNYNSNFDGFVILHGTDTMAYTASALSFMLEGLDKTILLTGSQIPLTHIRADASDNILHSLLIAGTITIPEVTIYFNHQLLRGNRATKVSTSEFDAFRSYNYPPLAKVGTKLDVNWNVVLPKSNKPFTVHKSLSPEICVLRFFPGIKMHVIEAIVEDLINHERAALILQTFGSGNIGRNDKLLDLFKKASNKGVVIVNTSQCHTGSVSGAYENGRVLGEAGVVFGNDLTCEVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT7</accession>
    <name>I4YIT7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_55815</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955723.1">
        <property type="nucleotide sequence ID" value="XM_006955661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT7"/>
    <dbReference type="FunCoup" id="I4YIT7">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIT7"/>
    <dbReference type="GeneID" id="18472744"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55815"/>
    <dbReference type="eggNOG" id="KOG0631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_6_2_1"/>
    <dbReference type="InParanoid" id="I4YIT7"/>
    <dbReference type="OMA" id="GFHDTYF"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="11">
        <location>
            <begin position="130"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="12">
        <location>
            <begin position="414"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="516" mass="55235" checksum="DE36593986CF0ECC" modified="2012-09-05" version="1">MVAPADLPLVTVDAIDKVYPADRVAAQGVRWNNLVEDFKKTYGYKPTCIVRAPGRVNLIGEHIDHALFGVVPMAIVPDVIIAVGPRNDTKEIRTSNVDKKYGPTAFTPSKNSNGEAVVDIDIRQLQWHSYVKAALLGYLKHPHSGGDSIGLDLLYDGTVPAGSGLSSSAAMVISSLLAMLTANGKVDGLTKGDLVKMSMGAEGNVGVNTGGMDQAASVISTPAAALYVQFYPNLAGEPVPIPKTQPEISFVIANTLVTSDKATTAKFNYNLRVVETLAGASLLAKRLGMNYKPKDKVAYRQVVSDLAGGEHSLTGAGVNKSDITASLRQAFKDALDAIEKHLGNSAERDGLTEEELIAALGISKEEFTEIYLKLAVEPIGGKYRLHIRAKHILEEALRVLEFRKTIETETESLPKALGEIMNKSQESCRDQFGCSCKEIDEITSIALEEGALGSRLTGAGWGGSTVSLVPAEIVPQFIANVSKRYSKYQGLPQEQLDQAIFATLPSSGACETVHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-01-24" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ08</accession>
    <name>I4YJ08_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955788.1">
        <property type="nucleotide sequence ID" value="XM_006955726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ08"/>
    <dbReference type="GeneID" id="18473133"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59023"/>
    <dbReference type="HOGENOM" id="CLU_2186006_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ08"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="109" mass="11991" checksum="14286D2C66A9264A" modified="2012-09-05" version="1">MPLHLPFDESGLEASINEARDEVAKLSDNQALGYTVINGGKSIIKANGLSTDAWTQMIIQLAYSRLVAIEGSEMFQLRHTKQRQCVLLSMAAMNASDPLHLIALHLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-05-29" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ27</accession>
    <name>I4YJ27_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_66845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955805.1">
        <property type="nucleotide sequence ID" value="XM_006955743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ27"/>
    <dbReference type="STRING" id="671144.I4YJ27"/>
    <dbReference type="GeneID" id="18475160"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66845"/>
    <dbReference type="eggNOG" id="KOG2664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_814330_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ27"/>
    <dbReference type="OMA" id="HNERYAL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39132" checksum="AA5F80B4E7384849" modified="2012-09-05" version="1">MINRFYRHLPTFNEKNSYGPSSQAIDIDSFINHARSLNKPTIDNDINEDIINQHIENIRKEDDEMLSSPPLLQSIKDHSDRYKNRRKPKTIDKANEIKDIFEPPQRCFQHDSMTEYYMRNTDEGDVNAAETQSIDARGKNWDYSTVVIEVESKVPTLNGILERTDVVLLSSKHTLGHLRDKLKCEADGAPYASSNKSSCFVFEAVAYLDKRKEGWETYEESVKQLSLRDISTKSIENVPLGELPIRTGRFGWMVHSGGCEHALQITGVRLKGTRETLPRYKFSKLDRTQKPICGICDKKQAALVTYKDRLGAENSTYWCDICFDNIHQGFNTNDLNVYPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ43</accession>
    <name>I4YJ43_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955820.1">
        <property type="nucleotide sequence ID" value="XM_006955758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ43"/>
    <dbReference type="GeneID" id="18475165"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66861"/>
    <dbReference type="HOGENOM" id="CLU_538842_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ43"/>
    <dbReference type="OrthoDB" id="10420957at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="58437" checksum="91E8A53B5F26DA60" modified="2012-09-05" version="1">MEVDKVKISQRVINLLKNLSSKALSETAIDLIDDSKSPKPRGNITDLLEKYNIHRAKQTQKTQLTRELTADFPLGFTYRQLAIIYFNIFKEKPLLLEWKCYKLTNSKSPSIHEFTEVFINTLSVTQSFGLYQTFVPTSIIPSQSEYGIEGTTIFTLIFTSMQPETLPPSNHRIMFIPLLKAGKILMTSLNQSFKPFFDRALLNAFGHAEGLQYTNLRDTNVGALKSLTLDPKSQGIWKRLTNHCVNIPNPLEEAPDRIDEDPLIADHELKPPSLGEKYDGIIVQSEERNQEMLRRQREALDLWGDGDDLPQISSLSFNVQMPWKIKDEKGTLDCSLSFHGKNVYAGLRQWELEGKTTEAGLPGWLTQSMECGQTENLLVKTSRKSNKWTYVFEDEEDYDNIYGPLLDSDTEDEGTSQHKRRRDKDLEESRKKSKQIEDLQQEREQERIKSKYENPQRPIQSGRDDNIQRAYQIFARETPLKLKKAREEMQKQPRPPRRPSFRSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ50</accession>
    <name>I4YJ50_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955826.1">
        <property type="nucleotide sequence ID" value="XM_006955764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ50"/>
    <dbReference type="FunCoup" id="I4YJ50">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ50"/>
    <dbReference type="GeneID" id="18473143"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59044"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110332_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJ50"/>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="134" mass="14892" checksum="13AEE95C7F9968EE" modified="2012-09-05" version="1">MTTSGRYLRRGAADDEDASKLKLGAEFNDMGCLTISEVKHLLDGRAGEADTPVFKKTSEYVNTFTVFGSKESAISVREALKKDEKMTQFEQAQIGNLVPGDVEEAKSLIPSLYEHDEMTVQTILDELDALRKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJG6</accession>
    <name>I4YJG6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955934.1">
        <property type="nucleotide sequence ID" value="XM_006955872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJG6"/>
    <dbReference type="STRING" id="671144.I4YJG6"/>
    <dbReference type="GeneID" id="18475190"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66966"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_2_1"/>
    <dbReference type="InParanoid" id="I4YJG6"/>
    <dbReference type="OMA" id="FPPRMGK"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="30647" checksum="E651908EA4664D8A" modified="2012-09-05" version="1">MQILRNTFVVTGGLGGAGRSVVTSLLDQGGYVVILDLAEQKAGEEATKHISTDRAAYVRTDITNEDSVRNAMSVASEAFEKRLSGLVHCAGVAMTQPWTNRLQESIERAKRLLDINYMGTYITNALFADAVNERFEPEKMASGELFTTKEERGVIVNFSSIAGHQPYGRILAYTGGKAAVNAFSCALADFLGPSGIRVNTVSPSVINSANIGARLPYFLAELTKTCSCPARPIAPEEISGAVNYLITNGMMNGHDLRIDGGWRLIFDRSLDREDPRILAPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJG9</accession>
    <name>I4YJG9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_34683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955937.1">
        <property type="nucleotide sequence ID" value="XM_006955875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJG9"/>
    <dbReference type="STRING" id="671144.I4YJG9"/>
    <dbReference type="GeneID" id="18471876"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34683"/>
    <dbReference type="eggNOG" id="ENOG502S3QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJG9"/>
    <dbReference type="OMA" id="FSAWGRY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="299" mass="34805" checksum="B50069CEA430BD4A" modified="2012-09-05" version="1">MDLLFYFAPPIVENLALRAFYKLRPDVKPAPNHPYRARCAIVGLYIAYTFLKMAWGYQPNVFKLLNVPIDADETRLNKAWKAYARRNHPDRVGLNKDTTLFVHARESYQLIQDPIRRVAYEKFGPSISQWRHCITLQDYIKRGLPGVFMYYLATFLSMTALSYFNTSYKSTAYMRFTLFFAMLTMELHLLTRPIPGFFKMAMIAKPMPYEIISFMHTLWLMFNIAIAQLGPQTKEVKGINNEAIRKLKPYLDDSQKVTMKSLEEVTDALESNIKALKKSGQPKEKVRRVIKEAFIDDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJQ4</accession>
    <name>I4YJQ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">WALSEDRAFT_62021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956015.1">
        <property type="nucleotide sequence ID" value="XM_006955953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJQ4"/>
    <dbReference type="FunCoup" id="I4YJQ4">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJQ4"/>
    <dbReference type="GeneID" id="18474705"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62021"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004304_0_2_1"/>
    <dbReference type="InParanoid" id="I4YJQ4"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="613"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="858" mass="96452" checksum="27C806FAD27B4C15" modified="2012-09-05" version="1">MSFFRRAGSSSDSDSSSEEEELLSSSGSEDEEAPPQKQEAKPMSRFLKTAGGDSSSSDSDSDDSDDSDESDDEDGPKKSRFLKDAPSDESDSEEETKKVVKSAKDKRVEEMEAVIKTLDNASKISDWVAINTEFDKLTRLVIRLQTLNEPIPAMFIKTLVSLDDDLKSDKGDTKKKLNATNNRAMNGMRQKVKKSIRDWEKDVASYRENSEEFESKAAAISAAHAPGVAPTKPRAEKAAEAADADELGFATIGKAGKATDEPTITPETLFRHLAGILEARGKKNTDRTEQVRTLERLLKVASTPYSRIRVLLALISSRFDYNATNQAHIPPQSWIQARAEFDSLIDILISQPQYIVKEETVEYEDSVERKPQSADDIVEVRGSLVSFIERLDDEFTKTLQNSDPHSLEYVERLSAQKTLYQTTVKTQAYFELIKAELPVSRTVMRRLEHIYSKPDAVVEVLEKAASQALGQLKSTITPPQSAFSSTKLVHQLCTYLYNAADGLLRTRAMLSHIYHHSLHNNYHTARDMFLMSHLQENVSRADVATQILFNRTVVQLGLCAFRTGLIREARDSLREIFQSGRPKELLAQGVTQQRYMTMTPEQERAEKSRQVPFHMHINLELLEAAYLVSCMLIEIPKLASATGDPDAKRKILSKAFKRQLDFAERQAFNGPPENTRDHIMQASKALQNSDWEKCRDLIHGIKIWSLMQGETQTKEMLTSKIQEEALRTYLFTNSAFYENISISILASAMELNEKTVNSIISKMIWSEELSATIDQSNNVVVFSKAEPTKLQSLSNQLLDRANSLVELNEKTIQLKFDDGTNKSDDLSARIRRGNRGHGHGQPKASRQQFANPTRKVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJU7</accession>
    <name>I4YJU7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956057.1">
        <property type="nucleotide sequence ID" value="XM_006955995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJU7"/>
    <dbReference type="STRING" id="671144.I4YJU7"/>
    <dbReference type="GeneID" id="18473205"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59166"/>
    <dbReference type="eggNOG" id="ENOG502S1T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1125260_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJU7"/>
    <dbReference type="OMA" id="FLRPPNI"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="26954" checksum="CDC639B112E39A8D" modified="2012-09-05" version="1">MRNYVYSQPEQSFGMTDYKPSNVKSYRKRERGAASRRGGIIGSIFRWIFCVLILGISIVIGVLATIVLYVKPPNITFVGVREPENGSTVSAVNNALNINFDLEIVVDNPNTFGATFNSLNAQLFYGGTGIPIGYGRVEDIDIDGENTTDFRYPFHIVYQANVDPDKTVLSGLLNSCGLVSQGENPPIDIDYDLHVDIKALSVNVKQTISNSMSVQCPGFSESMLEEAVGDTISVSDLVGQLTRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW5</accession>
    <name>I4YJW5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956073.1">
        <property type="nucleotide sequence ID" value="XM_006956011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW5"/>
    <dbReference type="STRING" id="671144.I4YJW5"/>
    <dbReference type="GeneID" id="18473207"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59174"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977286_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJW5"/>
    <dbReference type="OMA" id="GHEWADL"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="87"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="262" mass="29920" checksum="F8667F6FD493088D" modified="2012-09-05" version="1">MSFIDFEAPTNFIEREKDIDLDNLDNFDSGLTSKKRDREEDVDEIFRSLDDEDNDDGTTPLNSTSAFDNDKDNDEAGTEKPKRVLAKIDPERLLGQNGLPALLASSKNWKFKGKGHEIEDLKKLLSYYQLWAHKMFPKTQFSDTIEKVEKICHQRRMEAALKGWKDANDHKRTLELEGGVEIPDNLEREQEMDINIDQNNTTDVGNDDRRSASPALFRSPSPPADIPPDEDIEHLQRNDDEATRDALENEALAELEKELGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y534</accession>
    <name>I4Y534_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_34299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JH668262">
        <property type="protein sequence ID" value="EIM19076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960883.1">
        <property type="nucleotide sequence ID" value="XM_006960821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y534"/>
    <dbReference type="FunCoup" id="I4Y534">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y534"/>
    <dbReference type="GeneID" id="18471854"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34299"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="I4Y534"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="497"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="618" mass="70048" checksum="38F5A2C3A20A0916" modified="2012-09-05" version="1">MSTQLPYIQNTEPERSILDSYRTACALELNKTLDLPLEKAFEGVHVGSKNGDFHIALPRFRLPGDVKEHAQKVHDQFKPNEYIDTCIVKQGFVTFQATTKNFIRDVLDQIHTMSNKSPTGKPEFGTSTVAGQGKHVIIEFSSPNIAKPFHAGHLRSTIIGAFLANLYEACGWKVTRMNYLGDWGKQFGLLGVGFERYGSQEKLKADPIAHLFEVYVRINTEAKEEDEKLGKKAQDDEEGAEEEAAPTEAGNTINDQARRFFKRMEDGEEGPLSLWKQFRDLSIEKYKDTYARLNIHFDVYSGESQISQENQNKAIDVLTEKGLIKQSGQSQIIDLEEYKLGKAVVKKMDGTTLYLTRDFAAAAERYDTYHFDKMIYVIASQQDLHTAQLFKAMDLIGYDWAKNLLHINFGMVLGMSTRKGTAVFLDQILNEAKSVMMDVMKKDSTNKYDQLEDPEWTADTLGLSAVKIQDMGGRRIMNYKFAWDRMTSFEGDTGPYLQYAHVRISSIQRKVADETVLPEDPTKDVDTSLLTEPKARELVYLLSQYPDVVKTALKTHEPNNIVSYAFQLTHVVSSLLEILKVKGQEQKLAQARLYLFMCAKDVLGSAMRLLTLTPLEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y549</accession>
    <name>I4Y549_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960875.1">
        <property type="nucleotide sequence ID" value="XM_006960813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y549"/>
    <dbReference type="GeneID" id="18475135"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66692"/>
    <dbReference type="HOGENOM" id="CLU_1778913_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y549"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="146" mass="16971" checksum="CE57BF2D360BDFB0" modified="2012-09-05" version="1">MASTSSHTSKEVDITRENSASNLLEESKDFFEISRTWEVLHRELFNSTLKYGEDAKVFYRRLEVLYNELQKVDTIIGEEAKKDKAIRALPDEMKETKVSLYLNYSQTFGYDDLIKKIINYYNASLIFEPTIEETPVNQTTSLKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y557</accession>
    <name>I4Y557_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Skb1</name>
        <name evidence="12" type="ORF">WALSEDRAFT_41813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960855.1">
        <property type="nucleotide sequence ID" value="XM_006960793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y557"/>
    <dbReference type="FunCoup" id="I4Y557">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y557"/>
    <dbReference type="GeneID" id="18472233"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41813"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010247_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y557"/>
    <dbReference type="OMA" id="IKYAWYE"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="322"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="495"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="358"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="689" mass="78503" checksum="A4FD099D9B9F2A1C" modified="2012-09-05" version="1" fragment="single">MSGSRVPIANHIDQTLLNKNPSILDHVNQSFEYDYDAITLPFTKSSWKDRWQRYCVANEEDVKKGRARASYIAGQSENVVQDRQIAKEAEIWRLTRVYERKEVNVSKLDECESIIAFASDWLELDSPDEGIRFDSEIALKQEVAYASYLSIHTLILPPPRNRKFISDYARSVMAALDSSTYLQISVMIPVSDPTERASEDKIDPSSTWEVWDGIRTLCDYSPRLGVALDLTQPLPPPSAIKRWASEPTRQIIIPANVFVGNAKGYPVLSKPCQEFIKDQIKTLPMIILTHTYDKIHSSGGSKAYVQYLRFMEKLSNDRATSVEQFASGYMDWLQAPLQPLLDNLDSTTYEIFEKDPVKYQKYEQATYLALLDKEPNSLTRLAVVGAGRGPLVQGAINAVDAAGDGRKIHIMAIEKNPNACVTLQSRLDEWNDSKSATVELVYGDMRIIELEDERKNDILISELLGSFGDNELSPECLDGAMRLLKPYGVSIPSYYTSYIAPLSSSKLYNEVMHMGEAKSAEMPYVVMFQAVNILSGMNEEAELKPIQQCWSFKHPSKYEFVMDRNGNPMSNYHNTRAAHLTFSIPHAGVLHGLAGYFEAHLYGNVWLSTHPERYDQKMLSWFPIYFPINMGVYLPTKSEVDVHIWRLTDNKKVWFEWSVEVFVNIDGQRVKINQTKLHNHDAKYNRIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y558</accession>
    <name>I4Y558_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_41816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960856.1">
        <property type="nucleotide sequence ID" value="XM_006960794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y558"/>
    <dbReference type="FunCoup" id="I4Y558">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y558"/>
    <dbReference type="GeneID" id="18472234"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41816"/>
    <dbReference type="eggNOG" id="KOG2253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009938_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y558"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="630" mass="72012" checksum="D94A6C05761F1970" modified="2012-09-05" version="1">MYNRPSPGQPRQSAPSFKAASEPELIPGSEKLTVFIGSISAGVSDEWLERLLNAAGNLVTLKRVRGPTGKPQAFGFATFAEPDSVLRAIKTLNGISVPPGERGQPRKNLLVKADEKTRAFLDDYEKTLLKTDDEEMEEHRAEELIAKILDHMSDPTLHAKGPNLTGSVPIADDTPAHLRDLPPEEIPEEHRQETLNMIEMFRSGAMVNPAVKSKQIQRLEREQRDRERLEREQVERERERDQQTHMRKWGSRSSFGGNDPQSYNKPMGFVRSSSGQQQPEPESMPVTFEQAMNLVEQDERAENDRLARRLRDRELAFRDRERKFEGKERARLNEYDRDLARERANDSSDTSARESALHKLLAVDDDKLAEKGELFYDNRRRWRNARSQARRKEEAADEADRMAEINESEKVKRDTEAFLQQQAIEMENFAKEQKKKGVLMDDSMPIKLSAAAAQHPKPTSEQVESSKPVLHKSAFNDEEVDENGMPMQKRKLVKLDYSGIVPDQDELTPEQREAARRVRLREIANGVSLDYVQLSKIDINWDAITDVVISKKLIPIAESLMKEYFGEADEEMLEVVSDQLKSHQGIDEFVETLEPVMLEDSKTAAIKIWRRLAFESITALENLNTDNFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I9</accession>
    <name>I4Y5I9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_61576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960728.1">
        <property type="nucleotide sequence ID" value="XM_006960666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I9"/>
    <dbReference type="FunCoup" id="I4Y5I9">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5I9"/>
    <dbReference type="GeneID" id="18474615"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61576"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y5I9"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="444"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="574" mass="65667" checksum="7FEB9C7AC5ADD532" modified="2012-09-05" version="1">MAQRKLLTEVDRTLKKVSEGVELFESMYEKLQTSNNQTQKEKLEVDLKTQIKKLQRMRDSIKTWISSSDIKDKSELMSSRKLIETQMERFKACEKEIKTKAFSKEGLIAATRLDPKDQIKQECSNWLGHFVDELSRQIETAEAEIEQLSGATSKRSKKSNATQERVSELEQLNERRNWHISRLELTMRLLENDQLSVDQINNIKDDIQYFVESNGEEEFEEDEGIYDELNLDEEEQMYGMGTANAQPNDEQASSHDSISVTDEPVQPPSKPSKKSSIDEDSLTPKKTKKPSITSPDSSNNGAIPAPNFNQPPVAKSTASPAAQQAKPVPAPPTIKYATAAANAVANTASSAPVDDEHIEEQPRESQDQLESVEVDGSQQEDGQSIPPTQVQRSESEEQSQTSTASAKGLPYVLSDLAASFENAKQKSRSNSPNRLHQALESTMSGVPEPSDADRPRYYVPKNLWTSPSYYPQVPKKDLEHSNLFSRLETDTLFYIFYYMQGTYQQYLAARELKKQSWRFHKQYLTWFQRHSEPNQITDDYEQGAYIYFDWEGTWCERKKNDFKFDYVYLEDTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5L7</accession>
    <name>I4Y5L7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_49230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960654.1">
        <property type="nucleotide sequence ID" value="XM_006960592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5L7"/>
    <dbReference type="FunCoup" id="I4Y5L7">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5L7"/>
    <dbReference type="GeneID" id="18472491"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49230"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015750_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5L7"/>
    <dbReference type="OMA" id="CVMHPRF"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="70"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="306"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="438" mass="50122" checksum="76E625FD52363B54" modified="2012-09-05" version="1">MKERTQSRINPNADAKRTDIKAPGSGLGTASHPLLATLSGSASPANVSANAPKFTSIKANKGATPAVSSNPYLQDQGEDTNRRKRQFVFSRPGKYIAQADAVRNEAKLEELKRKIDENARKAGITGESEAASERAVKRPPPPAVEWWDQPLLHNQEAYPEDLNKDAKIETEDSLITLYVQHPIPIPAPHDRSRFAKLDLKLTKKEMKKMRKQRRQAELSDKRDRIKMGLLPPDPPKVKLSNLMRVLASDAIQDPTKVEAKVRRDMQKRKIDHERMNEENKLTKEQRHEKDENKRLENEKARGTRGAVFKIKNMSNPSHQFKVRKNAQQHGLSGCWLQNEKFHFIYVEGSEKSMKAYKRLMTVRIDWTEETRGPTNDEGEEQPQSLADNYCHLIWEGPTRDRLFNRFITREMPSDREAKEFLGESLAGYWDTAKVQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M2</accession>
    <name>I4Y5M2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">N-acetyltransferase ECO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_70714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960659.1">
        <property type="nucleotide sequence ID" value="XM_006960597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5M2"/>
    <dbReference type="STRING" id="671144.I4Y5M2"/>
    <dbReference type="GeneID" id="18475779"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70714"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y5M2"/>
    <dbReference type="OMA" id="PSITHQE"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32540" checksum="5099FCF418F93386" modified="2012-09-05" version="1">MMEAPPGKKPKVVYKRKGDNVLELNTSNVKSATKIKLRDSIPSKAKPKNKKDTKSSTQLYLDFGQRNAHTIECKDCGMRYTRGNTTEISLHETYHSTTIFGIEWNHKMTQSVKSLEKIDRLGILRVDPSNASQYVTRKVEEVHALLHSSLDAPSFTESIKNTARTYLAIEDNRIVASAVTTPMSSAYRVDISRMYLEGAQLGDIQFNSISVNKELRENIKVGIHRIFVLPAYRKKGIAMLLLNNIAASEVYGNTLTSDDIAFSQPTSDGARLAYKWSKRLDFLIFDDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R5</accession>
    <name>I4Y5R5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_34173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960699.1">
        <property type="nucleotide sequence ID" value="XM_006960637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R5"/>
    <dbReference type="GeneID" id="18471831"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34173"/>
    <dbReference type="HOGENOM" id="CLU_2122968_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5R5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="114" mass="12610" checksum="D57F3D2120376C36" modified="2012-09-05" version="1">MFGNYGYNSNVRDMEPRALERRLGLDACCNGIYDEPPRKREVDYAPNQEPLKIRDGSDYASMYDAVMNAAERAGMLRGDPPPSWYENPSNLGSVVLAGTAVFPYLVQGLSSGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5W9</accession>
    <name>I4Y5W9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_34131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960637.1">
        <property type="nucleotide sequence ID" value="XM_006960575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5W9"/>
    <dbReference type="FunCoup" id="I4Y5W9">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5W9"/>
    <dbReference type="GeneID" id="18471818"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34131"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5W9"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="249" mass="27460" checksum="7221054AABC7D33B" modified="2012-09-05" version="1">MTRTFFVGGNTKMQVTLKNLNEVIETLNKADLDKNTEKVLAVPAIYLSEAKNRLNPDIAVSAQNVYGKNTGAFTGEIAPTQLKDFDVKWTLTGHSERRHIFKENDDDVAHRTQGALNEGVNVIFCIGEKLDERESGKTKEVVEHQLNSLKKDIGNDWSKIVIAYEPVWAIGTGKVATPEIAQEAHADIRQWLKSNLGQDAADTIRVIYGGSVSHTNCGDLSKQPDIDGFLVGGASIKPEFVQIINSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y6</accession>
    <name>I4Y5Y6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960528.1">
        <property type="nucleotide sequence ID" value="XM_006960466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y6"/>
    <dbReference type="GeneID" id="18475765"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70613"/>
    <dbReference type="HOGENOM" id="CLU_1778912_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="146" mass="16602" checksum="7751222F17713817" modified="2012-09-05" version="1">MVQRLVNPALDTVFTRSRTTTKIIDIKLFDISVHSIHDVFLFSKHPRLTSSLYDMGRKWGAIMRYYPPEIVKMSIPPVSLEFPGNKATGAHPAISVVHEIALVAFTNTFEGDIVDIISFDLTYQRRLCELMLPHDGELIDNSLRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y656</accession>
    <name>I4Y656_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_34019</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960480.1">
        <property type="nucleotide sequence ID" value="XM_006960418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y656"/>
    <dbReference type="FunCoup" id="I4Y656">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y656"/>
    <dbReference type="GeneID" id="18471795"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34019"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y656"/>
    <dbReference type="OMA" id="LMECVDM"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="14"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="450"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="450"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="579"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="624"/>
            <end position="626"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="822" mass="89174" checksum="A74D48E407D485EA" modified="2012-09-05" version="1">MISLHSKNENPKRRICVLSSGGDAPGMNAAVRAVVKMGLYRGCEVYIVREGWAGLVAGNTTNAPTEVRQSRRAGTYKGKRDTEGENFAATYGEGELLQEGAGEGLKGRHILKVGWDDVRGWMDIGGTLIGTARCAEFREREGRATAAYNLVSLGIDALVVIGGDGSLTGADRLRGEWPSLLDDLEKSKRIDSEQRKRHAHLTITGVVGSIDNDMAMTDITIGAPTALHRISEAVDSIGSTASSHSRAFVVEVMGRHCGWLAVMAGLACGADYIFIPERPPTTEDWESEMCNLLKSHRDHGKRKTIVIIAEGALDRQLKPIKPAYVAEILTKRLQLDTRVTTLGHVQRGGKPCAYDRLLATLQGVEAVESVLDSTPSTPSYMIGLKENKVSRTSLMEAVKATASVGDAIEKKDFKTALGLRDPEFQENLEAFDYSTIIEPKKDMSRSQNLRIGIIHVGAPAGGMNAATREAARFCLARGHTPLAIYNGFEGLWAEGGNSVQPLSWLQVDNWSSRGGSELGTNRSLPADDFEKTSEALQTHNIDALLLIGGYEAYTAISSLKKARTHYAAFQIAMAVIPATLSNNVPLTEFSVGSDTALNALVDACDAIKQSAAASRNRVFVIETQGGKCGYLATVGALATGANIVYTPEIGMDLELVQKDVEFLKRRFALDIKGKSDGRFIIRNEKSSQVYTTEFLTNMLKEEGKDLFDSRAANLGHTLQGGTPSPIDRARACRLAIRCIKFLEEHSTSRQAGAKDDSAAVIVIENGQVRLAPIADVAKNADDKNRRGLHPWWLDLRHLVEILSGRRTLAEGRHHEDTIGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6A7</accession>
    <name>I4Y6A7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_22293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960424.1">
        <property type="nucleotide sequence ID" value="XM_006960362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6A7"/>
    <dbReference type="FunCoup" id="I4Y6A7">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="GeneID" id="18470919"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22293"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="InParanoid" id="I4Y6A7"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="89"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="271" mass="30504" checksum="4E0AC6D79F97E7B1" modified="2012-09-05" version="1" fragment="single">DQGIAGLGAGVASTIAMQPLDLIKVRLQVSERSKQKDIWKSLLKKQEWKGMWRGLTTNIVGNSISWGGYFWLYTKVKNRLHDRHPNRKLSAVEHLYAASEAGSIVAITTNPLWLIKTRIFTTKRNDKDAYRGLIHGMIDIGKKEGIPGYWRGTLLALFGVLQGAIQFAVYEELKLYRAESSGNVNENLPWLVCHISNWEYTLMSGFSKLVALGMTYPYQVVRSRIQNEKAYTTIRQCVISTFRSDGLLAFYQGAGINALRILPGTCVTFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6C3</accession>
    <name>I4Y6C3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_61422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960440.1">
        <property type="nucleotide sequence ID" value="XM_006960378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6C3"/>
    <dbReference type="FunCoup" id="I4Y6C3">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6C3"/>
    <dbReference type="GeneID" id="18474527"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61422"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="InParanoid" id="I4Y6C3"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="202"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="375" mass="40114" checksum="38AC2AA47BA53418" modified="2012-09-05" version="1">MSAQIITCKAAIAWEAGKDLVVEDIQVLPPGPDEVRIKVDYTGVCHTDAYTLGGHDSEGKFPCVLGHEGGGTVESVGDNVTDVKVGDHVIPLYTAECKDCKFCKSGKTNLCQAVRATQGQGVMPDGTVRFKCRGQDVYHFMGCSTFSQYTVVSKFSVVSIAKEANLEKACLLGCGITTGYGAATKQRYIQGAQVAIFGVGCVGLAAIQGARAAGATRIIAIDTNSKKKSHAIHHGATDFINPLEIKDKSIQEHLVEITDGGLDYTFDCTGNVKVMRSALEACHKGWGESIIIGVAPAGTEIATRPFQLVTGRVWKGSAYGGVKGRTELPGIVLDYLNKKLDVDTFHTHSRSLKDINEAFHDMHGGDCIRCVVNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6C4</accession>
    <name>I4Y6C4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_70540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960441.1">
        <property type="nucleotide sequence ID" value="XM_006960379.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6C4"/>
    <dbReference type="GeneID" id="18475756"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70540"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_20_3_1"/>
    <dbReference type="InParanoid" id="I4Y6C4"/>
    <dbReference type="OMA" id="GAWKPRG"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1483"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1583" mass="176818" checksum="96C83D6CC931B445" modified="2012-09-05" version="1">MSGNIRVVVRCRPLNSREIARGAKGLIRMEGNQTFLEPPPPGTLAAGEKATAKKTMNFAFDKSYWSAGPKDEPGYASQQTLYNDLGDELLQHAFEGFNCCIFAYGQTGSGKSYSMMGYGEDKGIIPLTCESLFNRIASNQNPNLGYTVECSYMEIYNEKVKDLLNPRNMNHLKVREHPHLGPYVEDLSKLAVNSYDEMMNMMDEGNKARTVAATQMNATSSRSHGVFTLILTQKRLDVDTGMEGEKVSRISLVDLAGSERANSTGATGQRLKEGANINKSLTTLGKVIAALAQASGAPDTPIKGKKKKAEDFVPYRDSVLTWLLKDNLGGNSKTAMIAAISPADYEETLSTLRYADQAKKIKNKAVVNEDPNAKLIRELKEELDALRLRAAGASQESTFDANVPPEKQMVQYKSHTGEIKSVSKADLQDQMEQSEKIMSSLNETWEEKLQKTQEIQVEREKALEDLGITVDKKGVGVSTPKKMPHLVNLNEDPLMSECLIYQIKPGQTLVGNMESEKVREIKLSGHTILDEHCIFANEEGSVHVTPLPDAMVMVNGNKLEVGVPHKLFSGYRIILGEYHVFRFNHPEDVRKARETRASKMNLSMTATELEALSMRDDSHIIRPGSPSESFAHTYDWELARKEATVKSGVNFDEYNDEDLDKIYEDLIKVRTVRKARPESRLSMVDGDSEWDDSNNGRLISGETITDDTSIDPSNAIDSEANSKIEAIPQQDVDIMKAQNDKMAQKIQLYQKQMTMMVRKHREMKRRDSNESFEPALFSDEELVLINVVLNKWKRLRRVAMAEAALTHAVLVKEANVMSNELKTGVSYNLTVDSGGALSFPQSALETIAGLGEFGEVSNKSSASTNAYRPTIAVRVIDRKNKSIYLWSLERLQQQLQRMRNVTLFVDRPNVSQHFATLEPFYSQDPPEYSFIGSSLLSLSPVLRQKAISYQLPIFCRYTTEALGSCKVELRIASVIPPTTNTNDTVSNGTLTPRSSTSATLSQAPGMVSSPSINQLFDSHIPLGSKVSLSLMVDHIRGLTYEDFNSIHLQVRLTSFAGPSADVEDVFSSPAVDLSSGDSTELKFRKTLTFTITEDVARHLSNEYAPIEFFAAVKPSFMSSLEKSDNAREVNRLTPELKTHKKTLSSSGRKSEVELLHEEKHDITAWLQMQELDASGEYKSVEVSSYGPLDPGSFNLRQGLQRRIVLTMSHQSGRQLPWNKVTKLYLGGIRLLDPKGRIHESSSSGDIELPLPKNQEVRYNADGSSQLSVTCGWDSGRHDALYLNRVTGSGQRVLLRIKWEVDIENCEENAAFGMDISVNINGRDRGTSKLLSFFSSAKILQKTSSLFTLKMSPPPSRSAKALWRTDTNGRYIHGEEKLGDWKARGISLVEDYDALMKREKLIADVQATKAVMSAIGSSKAIKRTKADDSDQLASKVVDTWKSSLCGPKLVSVNDPIGLENEVEPLTPLDLGYTPTVTLQARTETKSKSGYMFHLTNAHSDEWSRRFFVLRRPWLFIYTSSDELDEVGVVNLSSVKLERSREIEDLLQRRNLFTIYSQSNSYILQSANEKELVDWWRKINPLQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J6</accession>
    <name>I4Y6J6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960386.1">
        <property type="nucleotide sequence ID" value="XM_006960324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J6"/>
    <dbReference type="FunCoup" id="I4Y6J6">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6J6"/>
    <dbReference type="GeneID" id="18474502"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61388"/>
    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011759_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y6J6"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="100"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="458"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="582" mass="69225" checksum="EAD033CA46737755" modified="2012-09-05" version="1">MSSSYKRYRSDNDFNQEAGRETKRERSVDNPINYDDDNKFKWQKKEERDRKLGLSAQDAAIRDQKRRAEAQAELEKLTRRRQQREIERKEREDQNTRRQRMNESAQTQEWLNKEDEFMLEQKRLRALMRIRGNRAQPIDFLCLNLKFAHPDTTHTRDDEEELETGLEVDLDEPYHILENLNLNETKALHKDICEFLDLEIAEANKDFWHCMLAVCQDKLERIAQSMGGSHVVDEDVEEQIEMILKGKSLQQLTQLQQSIQNKLRSDDAIDTEYWENLLKSLMVYKAKAKLNDMHKLVLNNRLSQLRERQKLEGERIESELTKTMTEDKQEKPTVADSTPAEDILADEYDPAMSPKPTHKNQLPYEDRQMPLILIENDVKNLMDRRRQLKNTSFIARSELPQKQVALRADDVGASIADVETENWFRLQDLQTPHNYADEFDNDDIFTETQEAAKVTYTWNDKNRPRKPRYFNRVHTGYEWNKYNQTHYDYENPPPKVVQGYKFNIFYPDLIDKTKTPTYKVIKNPDNSDISTIIFIAGPPYEDIAFTIVNREWEHSHKRGFRSSFDRGVMQLYFNFKKIFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6P3</accession>
    <name>I4Y6P3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_61368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960298.1">
        <property type="nucleotide sequence ID" value="XM_006960236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6P3"/>
    <dbReference type="GeneID" id="18474487"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61368"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="I4Y6P3"/>
    <dbReference type="OMA" id="AGVMACG"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698593" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="723"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="802" mass="87364" checksum="95686274BFD0E8FB" modified="2012-09-05" version="1">MYFNLKVVALAATLLGYTSAQSAPATNPNAPTNDNDAPADIGEEPPTVEPVPFNGDSEHLPTHPDFFPTPETPGTGAWAEATGKARDLVYSLSVEERVNITTGVGWGNGPCVGNIAPIRDVFPGLCLQDGPLGVRQVEQASAFPAGINVAASFDKDLAYQRGLAMGTEFKEKGAHVALSPSIDFGRNPTGGRNWEGFGADPYLQGELGSSTIYGLQDAGVQATAKHYFVNNQEHYRYTSSSNVDDRAIREIYLHPYVKAVQANVASVMCSYNKILQSWACENSYLLNGVLKHELAFQGYVQSDWQAQYSGTPSALAGLDMSMPGDSTFYSGWSYFGANLTEAVANGTVPEERVNDMATRIVAAWYLLGQDEENYPEVNFNFFDENDPTRGPVRDVKHDHASLIKELGSASTVLLKNDNNALPLDGSNLSAGIAVVGSDAGPASKGPNGCADRACVDGTVAVGWGSGANEFPYLVDPLSALEERGALDGFSVDNWLNNWDINNDGFNSVVQGKEAAIVFVNSDSGEQYLTVQGNEGDRNNLTAWNNGDEVVKATAAHNENTIVVIHAPGQLDVEEWVEHPNVTAILWAGFPGQESGNAITDVLFGYYNPSAKLPFTIAKQREDYGTEVVYHDSSDVPQLNYTESIFVDYRHFQQDNIEPRYPFGFGLSYTTFDLDNLQIEEVGETEHEEYDPDMFGASVQESLHKPAYKVSIDVTNTGEIYGAEVVQLYLQFPRHSGEPPLVLRDFAKVPLAPGETKTAEFELSIYDLSIWDTEKRQWVKPDHGLISVVFGTSSEDERIVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T4</accession>
    <name>I4Y6T4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">WALSEDRAFT_61381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960337.1">
        <property type="nucleotide sequence ID" value="XM_006960275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T4"/>
    <dbReference type="FunCoup" id="I4Y6T4">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6T4"/>
    <dbReference type="GeneID" id="18474497"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61381"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T4"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="207"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="288" mass="31679" checksum="684815B81319AC9C" modified="2012-09-05" version="1">MSTDKLQSTSWADDVDETIAAPEPQIKTITTPDSDVITTIEVRTLPDGKRVQVTRKFKKVLKKSNVNQAVADRKTWPKFGLEKGKPAGPDRATTTVGENVVLKLSAGNDSAVEEPSEEQLMKERLKSKKIVCRLCKGDHFTTKCPYKSTLGDLDSAQDSTQTPDESNANQGTAAAATSTGKYIPPSQRAGARASGAGPGGPSRDEYPTLRVTNVSEDTHEDDLRELFRRFGRVQRVFIGRDRETRASKGFAFVSFELRSDAEKALEKVNGMGYDNLILSVQWSQPRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y773</accession>
    <name>I4Y773_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_48524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960149.1">
        <property type="nucleotide sequence ID" value="XM_006960087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y773"/>
    <dbReference type="STRING" id="671144.I4Y773"/>
    <dbReference type="GeneID" id="18472455"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48524"/>
    <dbReference type="HOGENOM" id="CLU_167733_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y773"/>
    <dbReference type="OMA" id="MREDKGQ"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10746" checksum="F79BD0D16156BB15" modified="2012-09-05" version="1">MSGEPSKFNANYDSITGNLKESAGNILGYESLKESGAKQHASGEAEKQAATAKQYTEGATEGVQAKAQNVFGAVTGDKEQQAKGAAKETKLKLSATSHEKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7A1</accession>
    <name>I4Y7A1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960177.1">
        <property type="nucleotide sequence ID" value="XM_006960115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7A1"/>
    <dbReference type="GeneID" id="18475723"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70356"/>
    <dbReference type="HOGENOM" id="CLU_984192_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7A1"/>
    <dbReference type="OrthoDB" id="10378244at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="33329" checksum="74B53397CEA459D0" modified="2012-09-05" version="1">MSSAVFYVFIADIMWSNSQECYLERLPIEILQDIIDYEPTLACCMRNLLLLGHKHRFRTLSGPRPVWTIFGKRQTRRSVDRFFLYFDKFLEDNSKSEHVRILTLDLSYSGKSKAALWSVGYIAHMSRLLPKLDTIKMTLKDECDLHKFPQLKSVTNVAIRFLKCTRYTYVGSLLREKVPNAAVIYLDVQPKRYKTTRRIQRELLLGWAGELFVVCQYLHFPNLKRLSIFGRIPRYEFFEAYSYFRNGETQLHKPLDFEFGIMTSNTVLTVLNILAMNIINHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D3</accession>
    <name>I4Y7D3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960017.1">
        <property type="nucleotide sequence ID" value="XM_006959955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D3"/>
    <dbReference type="FunCoup" id="I4Y7D3">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7D3"/>
    <dbReference type="GeneID" id="18474409"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61234"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="I4Y7D3"/>
    <dbReference type="OMA" id="MYTGHTL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000058">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="341"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="64397" checksum="119AE370B1498B06" modified="2012-09-05" version="1">MPTKKLFDVIRTEETTFRRGILFLAISSSISLVIPASIGSLIDLFSGAKPDAFYGFSLPVVTSGLGLLFAVGAAANAGRAMLFRLAGQRIVNRLRVRAYSNSLKQDLEFADKGSGDTLSRLTSDSTILTDCVTQSLSDGLRASVFSVFGLGAMFFISSKLTTVMLAIVPPIAIGAVFYGRYLKRLSTASQDALADASNLASERLNAFRTVTAFNRQDDESRRFEKKIARVLELGRKEAVASGVFFGSTGFSGNMSVLALLAYGGHLVGLGEITIGNLSSLLLYSAYVGSSLSSLTSFYSSMMRGLGAGERVFALIEQKPQIKLGQGFDMPSVVGNKASGTIRFENCAFSYPTRPDATILRNVSFEVPQGQSVAIAGPSGAGKSSIIGLVMRFYDPSSGRVTFNGHDIRSFKPESWREVIGVVEQRPVLFAGTIEENIKYGMPNATSHEVYEAAMQANCEFIKSLPRGFHTVVSSTALSGGQIQRIAIARALLKKPTLLILDEASSALDAKSESQVNEAIRRILDQSQTTVIVIAHRLSSLKSAHKIVVLEDGIISESGSFDDLTSKQGRFRRLMAEQLSSVDTKQSEIIIDDRKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H1</accession>
    <name>I4Y7H1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960054.1">
        <property type="nucleotide sequence ID" value="XM_006959992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7H1"/>
    <dbReference type="FunCoup" id="I4Y7H1">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7H1"/>
    <dbReference type="GeneID" id="18474419"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61252"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062889_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7H1"/>
    <dbReference type="OMA" id="VMQFFAR"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="239" mass="26659" checksum="53ECD49DDAE9F8AF" modified="2012-09-05" version="1">MKIEELAQKRAISQRDFRQAKFEYIPSADGVDSNLIIYLHGLGDNISQFINLSKKLHLPQTASLVLEGPVPVPFFDEARMWYQSFDMLGNLIQNPDPRVALNLLNDLIQTLTSKFGWDHRNIHLFGFAQGGSVAVEYARSSNVRLGSVVNVLGPLLSYATGNSKSETPICIFTRPSRNVLDGSNFNKAFIEVKIFEGDKPGDEMPKDHGEWSGILKFWSDVLVSTPISDQSGQVYKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Q3</accession>
    <name>I4Y7Q3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959926.1">
        <property type="nucleotide sequence ID" value="XM_006959864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Q3"/>
    <dbReference type="GeneID" id="18471120"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29934"/>
    <dbReference type="HOGENOM" id="CLU_1490127_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Q3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697688" evidence="2">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="19156" checksum="023C76FDD151CB85" modified="2012-09-05" version="1">MKTSQIAQLLFAGTASAVVLQARQDYSHISKCLVDECSDYQGELVDRCNPEEDFEMSNKDLKNISDEELQFLACYCEVFQSANNECRSCLNQAPSEDAVTHDSICQQVSSSSSSSTSMSSTSTAGSTTTTASPSESEDGDNNDDDNSDSEDDDGDSGANAFSFKCSAMVASGLAVGAAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Q7</accession>
    <name>I4Y7Q7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_9162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959892.1">
        <property type="nucleotide sequence ID" value="XM_006959830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Q7"/>
    <dbReference type="FunCoup" id="I4Y7Q7">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Q7"/>
    <dbReference type="GeneID" id="18475846"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9162"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7Q7"/>
    <dbReference type="OMA" id="LKVACHS"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698628" evidence="6">
        <location>
            <begin position="18"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="382" mass="42448" checksum="648200C45A39C1F8" modified="2012-09-05" version="1" fragment="single">NVLIVGAGIFGLSTAYALLQDGYTVTIVEQSDQIPAAGSASTDISKIVRADYGNAVYSKMASESIADLEQNWTKEAFFHQSGMLVLGESEYAKESYEHVKAMYPTRVSMLDKHTIRDVLPKNVPLNPLEHTAYVNRASGWIESGRATAVLAERCEQMGAKLIPNFNVKDVLWKGDIVEGVENTNGDVLHADLTIIACGAWSTLLDEQLNKMLLASAQSVAMIKLTDDQYERYKDSPIIINLGTGFYMFPPTESKYFKISKHHAGYISKERNAPISLGNAREQLGKNEPAVSISKIPTDMYEELRGGLREVYPEIANDENLEWKTRVCWYSDAQNGDFIIDYHPKSNKSLLFATGGSGHAYKMYTILGKLVKDRIEGQLSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T6</accession>
    <name>I4Y7T6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959957.1">
        <property type="nucleotide sequence ID" value="XM_006959895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T6"/>
    <dbReference type="GeneID" id="18474385"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61193"/>
    <dbReference type="HOGENOM" id="CLU_897731_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697798" description="Autophagy-related protein 27" evidence="2">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34590" checksum="6DB8AA9D3EC3F892" modified="2012-09-05" version="1">MNFSRYIFMFFGSVFCSGAMTSSLPNDNGVLGSNKEAILSDPGAQLRTNTEPSFLGFNSMSPVYQRPDDPEPFRVNTFILFVGMPLAAIVFPLWATMATDFATAAKNKWIHWWLGDQQPIKRDGSPDWTVVSGYDCSQPQTCLLTDSVGDATFGILEDSESTQPSSYLSFDEAGNVKSRKVKISYPDPSGKRDMMYLNYRYETAPGHSDTQLSYDEVYNYVLGCADVSQLDKYADTGVFCGGMDNGGDWQAYIQLWAEDRDHEVFMNSLIIGEMNSNNVVLFGSTLIEADLLVCKVEACHILVVKYKYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W4</accession>
    <name>I4Y7W4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959985.1">
        <property type="nucleotide sequence ID" value="XM_006959923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W4"/>
    <dbReference type="GeneID" id="18473018"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58436"/>
    <dbReference type="HOGENOM" id="CLU_529146_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7W4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="515" mass="59298" checksum="FA8E131B0F92907D" modified="2012-09-05" version="1">MGLSNNNILYAAQNASRFEFDPETLKDKRTAAVIDIYSQCSFLVRMFYMGYTSSALIMLRLLDIAQNFDQTFAVMDYKPNVFEKHGPNDSLNKLNMNIRDGDFTQAVESYRSDQVGLTYGLPSRNIINKAKVSQISHLMAINKLVNTKNNVKLELAVAEADCHLHKKHMDLLASYDTVITFSEDGDHLLPYKPGQGKILANALAALNGLEKTRYYSQNKFYNFMSSEYHLTRDQTLLYWTLTTDNSCRRPNDLYINEDKRFNAVAYDAVKKFNLNIDKVIDHIITTVYSSCNSDYTHIKRKHLQKSLAKTFYQLCLEDADIEYLNLTCSKDLDTAVNNFYNKLLNRKLNLQKQKDIHLLHILLGNLKEDAPFPKDFPKLWQAECDAIAKTVVLPEGLILKAESSYPILKIEAESERELPATCDKCGKVCKNVIGVRRHKKSAHNETNRKRKRTDHICNCVICDEPINMRGYQNHINAHVRVCIEEDLLWRIKLAVGQLVHKYHRRFQRLQAIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y809</accession>
    <name>I4Y809_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959822.1">
        <property type="nucleotide sequence ID" value="XM_006959760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y809"/>
    <dbReference type="FunCoup" id="I4Y809">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y809"/>
    <dbReference type="GeneID" id="18474345"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61124"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y809"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="354"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="646"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="725" mass="77778" checksum="8A19B465ED52CF4F" modified="2012-09-05" version="1">MSALQRLKFSAEVLDAMATRKPVVALESTIITHGLPRGDNLSLGRKLEKIIRDNGAIPAHIAVIDGHPLVGLSDKQLEILALDESLNPLKISRRDLAVASALNRSGGTTVAGTICLASAAGIKHFCTGGLGGVHRGAERTWDVSADLTELGRSPVNVICAGAKSILDTSLTLEYLETQGVTVATVGETNDFPAFYSPKSGYYSPYNLTPVEAARVSLASDGLSSGALFCCPIPAEYAEEGARIQSSVDQAIKESQEAGIAGKETTPWLLARVAELTKGSSIKSNLALIENNAKISADIAVAYNQLQKGQEPEQKVYPMGHMKKPDATKPEVGKPPVRQPPQQVQEEKQTDIPADVMIIGASALDITSQYKDVVGENPQSTYPGVIKIGLGGVGRNIAEATNRVLRKSPISSMLVTPVGSDEFAETLKSATSKLKMRTDGFINTYHPTPVVNLLLNSDGELREGVSSFEAVEKLTFDEVKKVLTKHKPQLIALDGNLNSSLLADVMAYAEVNNIDTLFEPTSVAKATRILSGSGIPKLTYATPNIFELKALVESKQFGELREIDSYWETLNGLRLFQNFRDQLERNLPKNVLELGLPQMSVMLLPICKNLLVKCGSDGVLAVTRVKRDEFGDWKDIKSDKEASRVVHLPNDGDGVVVQHFKASVAERIVNTTGAGDSFVGALIAAVASRKGLTDSVKLANEAAMLTLGSQDAVSARLNYLSDDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y824</accession>
    <name>I4Y824_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959837.1">
        <property type="nucleotide sequence ID" value="XM_006959775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y824"/>
    <dbReference type="FunCoup" id="I4Y824">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y824"/>
    <dbReference type="GeneID" id="18474351"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61131"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067861_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y824"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="203" mass="22822" checksum="DD8A6812D98BF6D4" modified="2012-09-05" version="1">MSAEEPKPETAHVEEPQEESTAHFEPVVKLTETVETKTNEEDEEVLFKIRAKLFRFAKDSSEWKERGTGDVRILQHKETKKVRLVMRRDKTLKVCANHFLTPDMKLSPNIGSDRSWVWAVAADVSEGEPTAETLAIRFANAENATAFKDKFEEGVKLNGELKDDAPAKEDAPKEDTKEEAKEDAAAEETKGHPEESVDEAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y846</accession>
    <name>I4Y846_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_70105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959859.1">
        <property type="nucleotide sequence ID" value="XM_006959797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y846"/>
    <dbReference type="FunCoup" id="I4Y846">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y846"/>
    <dbReference type="GeneID" id="18475688"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70105"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023794_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y846"/>
    <dbReference type="OMA" id="RLQFQQY"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32138" checksum="BA8357C99486A868" modified="2012-09-05" version="1">MNRIEEFRNFCLNNKPTKLSDSKSREAPHSEQPTEINREAKYLLSTLNDLNKLIKSIPAQYAQNNASLDVIDEEVTSLLAVTSKRLKELDDKIEATLSTPLNFLQQLIGAASPDIQRQHQHGKLISLNALLIKLSTRYQSLQKQRQAKQRKYIPEYEQIDNIPPPPPSTSAQQLSQEQIQMLERENDELVESNKRDLIEIEKAQHSLLSITSLQSEILTHLTQQSKLVEQLYDDSLNSTGSLGDASKQLLQTRDRQESSRKFLVVFFIMAGLSILFLEYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y886</accession>
    <name>I4Y886_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_47814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959666.1">
        <property type="nucleotide sequence ID" value="XM_006959604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y886"/>
    <dbReference type="FunCoup" id="I4Y886">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y886"/>
    <dbReference type="GeneID" id="18472429"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47814"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y886"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="190"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="50733" checksum="329A932861B48367" modified="2012-09-05" version="1">MKNFLLVFSQSLLDFRLPELDSVAKALGLNFKRPSDDSVDLTSSCLVVELETDEQARLLASRCVLIKYIIRLLADGSTYEELHDNNKKAEYLWDQYKDSTFSVNVEAAYISLPREKRTAIIEQFSYMQLRGKVRCKNPEVQFEVYEEHKAIDNDPAIDHFNKQRVLHRVYFGTFLADGQRGLISKFDVKKRKYFGNTSMESEVTVLMANQALARKGTLVWDPFAGTGSMLYLCAFFGSYVMGSDLDGRQMRGQANKQNKGHPDSRSGGIIAAAKDYGVLDKFLDLFTADVTRIGWRLGGTLDAIVTDPPYGVRAGAKRIGLKEGAKSKESYSNQLIPPVQDYDLSHLAADLVVMSAYLLKKGGRLVYFLPTVNEEYKETDVPTCQGMRIIANSVQDFGKWSRRLITMEKVEDVETTESLQTILSNLDINKGSENVSHAKFREKFFKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E5</accession>
    <name>I4Y8E5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959725.1">
        <property type="nucleotide sequence ID" value="XM_006959663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E5"/>
    <dbReference type="GeneID" id="18471690"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33474"/>
    <dbReference type="HOGENOM" id="CLU_1877050_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8E5"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="136" mass="15016" checksum="E691960605D57E75" modified="2012-09-05" version="1">MTSLLIGLYNGFGGDSAWVFEFASLFLFSTAIAVYYSHALEPLSNIPLADDERMPPPYQHHNLHPPDHPPSLSPFDTPDVLLPSTPSYLISSIRDIAAAHLLSAVCLTGVLLFLAGDAYVDYERVINQDIQDRKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N2</accession>
    <name>I4Y8N2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C/H/G cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_40000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959581.1">
        <property type="nucleotide sequence ID" value="XM_006959519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N2"/>
    <dbReference type="FunCoup" id="I4Y8N2">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8N2"/>
    <dbReference type="GeneID" id="18472148"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40000"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161924_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N2"/>
    <dbReference type="OMA" id="TAVAYMR"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="239" mass="28685" checksum="4313F52643F5C0F5" modified="2012-09-05" version="1">MTFWNSSQIKECRSLEEYNKIKKLDKSKLKDDYYKLEVYSINILNKFGKKVTNRQRVLSTASVYLKRFYLFNNYLETDLYLIIITCLYLSSKVEELPLSIKYITNEFNKQFKTTYKIQDISKMEFNLINDLDYNLVVYHPDFRQFHLEDKINNLCYYILNDIYKTNLLLLFQPYTISIAIIVFAYSIQNNTEQSSQLLSQLNADLDIIQYIIQEILKLYKLLPTIVDNDIYDLYLNSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N5</accession>
    <name>I4Y8N5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_20809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959584.1">
        <property type="nucleotide sequence ID" value="XM_006959522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N5"/>
    <dbReference type="STRING" id="671144.I4Y8N5"/>
    <dbReference type="GeneID" id="18470856"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20809"/>
    <dbReference type="eggNOG" id="KOG0588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N5"/>
    <dbReference type="OMA" id="EWIQHYG"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="399" mass="44792" checksum="AA62F75176E80668" modified="2012-09-05" version="1">MSNKSPKKSSQTSQHHPETIGPWQLLKTIGKGSSACRVKLAKHRKSHQLAAIKIVAKSSLAPKQSSNHDDPWRALRAIEREIAVMKIIDHPNITSLYDVWETTDYIYMIMEYASGGELFSHLVERAKKNAARAKPGQPPPSRALPPDEALRLFQQLMYAVNHVHNLALCHRDLKPENILLAKDRQTIKLADFGMATLAGEDIVISKRKTKKGRKLLKTSCGSPHYASPEVVQGKPYVGHMADVWSCGVILFALLTGRLPFHDENLHVLLSKVKLGKFEMPHELDGPTHANARDLLLRMLTSDPSERITMPEILKHPYFTRLPPPIPMSTDSIPAALLPSTSSQKSRMSFQSDQLSEYNESLQRFSEEITDIDDEIFSSIRVLCQSESEETIRSRLTTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N7</accession>
    <name>I4Y8N7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_20664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959586.1">
        <property type="nucleotide sequence ID" value="XM_006959524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N7"/>
    <dbReference type="STRING" id="671144.I4Y8N7"/>
    <dbReference type="GeneID" id="18470850"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20664"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_10_1"/>
    <dbReference type="InParanoid" id="I4Y8N7"/>
    <dbReference type="OMA" id="MRITSAC"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="131" mass="14889" checksum="35B4DFB0979FB005" modified="2012-09-05" version="1">MSAARGVSTNFSEKPILTAKPTTDRTRIASNSRRKHNADGKAPKIFVCEVPGCGSSFTRQFNLKGHMRSHTNERPFVCSFDGCGKAFARQHDKKRHEALHQDNNKPYKCLGCSKKFARIDGLARHRKYIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R8</accession>
    <name>I4Y8R8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959617.1">
        <property type="nucleotide sequence ID" value="XM_006959555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R8"/>
    <dbReference type="FunCoup" id="I4Y8R8">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8R8"/>
    <dbReference type="GeneID" id="18471675"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33410"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8R8"/>
    <dbReference type="OMA" id="WELQFRE"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16485" checksum="6BCD00FAD22C2235" modified="2012-09-05" version="1">MTTIINLVLTIKLIYDIFRLIYPSINYQILTYTPKSSTIFRSYSPKELYEFNGKDESKPIYIAIGGLVFDVTKGKSFYGPDGPYGNFAGRDASRGMALHSFDEDILTPIDEPKDSLSDLTREQRSAMDEWIDHFKRKYTVVGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8W9</accession>
    <name>I4Y8W9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PkaC</name>
        <name evidence="14" type="ORF">WALSEDRAFT_33262</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959437.1">
        <property type="nucleotide sequence ID" value="XM_006959375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8W9"/>
    <dbReference type="FunCoup" id="I4Y8W9">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8W9"/>
    <dbReference type="GeneID" id="18471649"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33262"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_3_1"/>
    <dbReference type="InParanoid" id="I4Y8W9"/>
    <dbReference type="OMA" id="NDPFFDW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="121"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="433" mass="49289" checksum="7B7DCFA58BE52A25" modified="2012-09-05" version="1">MGLLEKLHIGHHSHSSSKDINSQNNQSKSSPAIPNSTTPNHPNTPPINNSDNDFSQQKDFKSQVESSNNHSNKLHPSLAPSTQLDDNKPTQQQLQQPATPNSSYNKVQPRKTQGRYTLKDFVLERTLGTGSFGRVHLVKSNHNSRFYAIKVLAKDQVVKMKQVEHTVSERDMLARVRHPFLVNLWGTFQDPKNLYMVMDFVAGGELFSLLRKSQRFPNPVAKFYAAEVALALDYLHSLDIIYRDLKPENILLGADGHIKITDFGFAKYVPDVTWTLCGTPDYLAPEIVQSKGYNKSVDWYALGVLIFEMLAGYPPFYTEDSNPMKLYEKIIANKPKFPSYFDPVAKDLLKQLLMADLSKRFGNLQHGSRDVFTHEWFKEVDWNRLYNRAIPAPYIPKIAGDGDSSQFDKYQENDVSLYGQAGDDTWGHLFKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y971</accession>
    <name>I4Y971_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_52154</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959539.1">
        <property type="nucleotide sequence ID" value="XM_006959477.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y971">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y971"/>
    <dbReference type="GeneID" id="18472576"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52154"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y971"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="242"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1541"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1596"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1596"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1735"/>
            <end position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM20513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1752" mass="192929" checksum="AC35C20703851C21" modified="2012-09-05" version="1">MSLGHQFSHSAAPVKGIKEVQFGLMSPEEMKSLSVAQIIHPEVIDESTGRPRQGGLMDPRMGTIDRNFKCQTCGEGMAECPGHFGHIELARPAFHIGFLTKIKKIIESICVNCGRLLADENDPELAKIVRTVPVGKRRFEAVHAYCTKISICKPDEPNENGEDAPPSQPGHGGCGRLQPAIRREALKLFSVNKQQKHDEEDDTKAQQDKRQLSAAEVYTLFKKIPDSDITLMGLSAEFARPDWMIITVLPVPPPPVRPSIAVDGGATRSEDDLTYKLADILKYTATLRRFESEGAPAHIISENEQLVQFHVATYMDNDIAGIPQAMQKSGRPIKSIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLELDEVGVPFSIARTLTYPERVTPYNILYLQELVRNGPNEYPGARYVVRDTGERIDLRYNRRADTFLQYGWIVERHLKDGDFVLFNRQPSLHKMSMMCHRVKLMPYSTFRLNLSVTPPYNADFDGDEMNLHVPQSEETRAEMSQIASVTRQIVSPQANSPVMGIVQDALCGVRKLTLRDTFLDSKQVANILMWVPGWDGIVPTPAIMKPKPLWTGKQILSLCIPRGINVFRSNEQKSSAPVDDAGVCIEDGNIMYGAIDKSTVGKSQGGLVHVIFREKGHIICKDFLSGLQVVVNYWMLHHGFSIGIGDTIADKSTMAYITERIGDAKDKVKGIIQSAESNQLEAQAGMTIRESFEASVNMELNQARDQVGKSAQHSLKDDNNVKQMVVAGSKGSFINISQMSACVGQQSVEGKRIPFGFKYRTLPHFTKDDFGPESRGFVENSYLRGLTPSEFFFHAMAGREGLIDTAVKTAETGYVQRRLVKALEDIMVHYDGTVRNSLGDILQFAYGEDGMDGSAMEKQHFIGMSASDEEFDRKFRIDLTDPVRGFKPGTLRVGLESAEGLQDKLDAEWKQLVDDRVLLREFIFKFRPGDSTLPLPLNIRRTIQNAQQIFRIDRRQPSDIDPASIVDEVHALCRRLVVIRGSDVLSQEAQENATLLFNILLRSSLTVRSIIEEHHLNREAFDWVIGEIETRFNQSIVAPGEMCGTLAAQSIGEPATQMTLNTFHYAGVSSKNVTLGVPRLKEIINVATNIKTPSLTVYLDEETSRDIVAVKNVQAELEHTTLKTITAATEIIYDPDPTTTIVDEDRDFVEAYFAIPDEEVAANINKQSPWLLRLELDRAKMLDKRLEMNFVAGKIASLFQNDLFVIYSEDSAEKLIIRARIVGDDPTTKEDDGVSEDVFLKKIENNMLSNISLRGIEGITRVFIVERKKEVIAEGGRFERQQEWVLETDGVNLSEVLPVKHVDGTRTYSNHCQEIFEVLGIEAARNAILKELRNVIEFDGSYVNYRHLALLCDLMTNRGRLMAITRHGINRADTGALMRCSFEETVEILLEAAAIGEKDDCHGIAENVLLGQMAPMGTGAFDVTLDIDMLKDVVVDPKLPAHRLNAQMAEGAMVVDEQGKMTPYSYGKNSYEAQIVGDDQAQFSPIAQSGDDGSNFEYMGYGQTPLVTGGATSPGYSPSSPTWSPTSPGYVPATSPAIGGAVSPWVPQSAASPGYSPSSPMVGISSPSYSPSSPRFSPSSPTYSPASPSYSPTSPRYSPASPAYSPSSPKYSPTSPKYSPTSPQYSPTSPRYSPASPAYSPTSPTYSPASPAYSPASPAYSPASPAYSPASPAYSPASPAYSPASPAYSPTSPSGANGVNGEQKPSWQTGNTSSGPSWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A6</accession>
    <name>I4Y9A6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959342.1">
        <property type="nucleotide sequence ID" value="XM_006959280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A6"/>
    <dbReference type="FunCoup" id="I4Y9A6">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9A6"/>
    <dbReference type="GeneID" id="18471634"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33198"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="InParanoid" id="I4Y9A6"/>
    <dbReference type="OMA" id="KIFQWAA"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="682" mass="74878" checksum="77E9D16040E0D5CE" modified="2012-09-05" version="1">MPQQGSYPVGPDTKLEGEGRPRRYFGNKSDEPLPTSPAEGVFTLYDILQYCGRVHGEKNAIAYRDLIKEHVEEKQVQGPDGKTHPKKWTYYELSDYKWLTWPQILKKVESIGSGLANLGLKKETIFNIYGQTAVNWQIIAHSCVRQNIPFCTAYDSLGPSGLQHSLAEPDVVGMFTNADLLPTVLSVIGDTPTVKVVIYDGQADKEQLDKLKSVEREGGEKLKVIHIDELEKLGAENLVEPTPPNKDDTVTIMYTSGSTGPPKGVVLTHENLVSAVAAVVKMLGHHLSAQDTFLAYLPLAHILEFIVELLVMFIGMPMGYGRVKTLTDQSTRNSKGDIQAFRPSIMIGVPAVWETIRKGILSKVGQQGALKKSIFGGAMTLKKTFGTKVPFVNTITDAVVFKTIKQQTGGRLRLTLSGGAALSKDTQEFLTTALVTVLQGYGMTESCGMCAILPPEFMQYNVVGIPVPAVEIKLVDCPEANYRSTNNPPQGEVFIRGPAVTKGYFKRPDVDEEVFVGDGWFRTGDVGQWNADGTLSIIDRIKNLVKLQGGEYIALERLESQYKSCPLVGNICVIANNNAKQPAAVVVPNESHFKAFLKDKGIGNANDISSTLEDKNVVKAFTAEVNQGGKKAGFKSLELLETVILTLDEWTPQSGLVTAAQKIQRKAIEKQYAEQIKKFYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Y0</accession>
    <name>I4Y9Y0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_54978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959297.1">
        <property type="nucleotide sequence ID" value="XM_006959235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Y0"/>
    <dbReference type="FunCoup" id="I4Y9Y0">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Y0"/>
    <dbReference type="GeneID" id="18472706"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54978"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="I4Y9Y0"/>
    <dbReference type="OMA" id="WVARATN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="362" mass="41347" checksum="16685636AA89FA25" modified="2012-09-05" version="1">MQTRAKTVPERQDHPPLKSCRSVDNYERLNHIEEGTYGIVFRARCKETGEIVALKRLKLEEEKYGFPITSLREIHSLLICQHPHIVNVREIVVGDTLNQIYIVMDFVEHDLKTLMHTMPEPFLISEVKTLLKQLLEATAHAHSNWILHRDLKASNLLMNNRGQIKVADFGMARRYADPVDEMTQLVVTLWYRAPEILLGEKKYTTAVDAWSIGCIFGELITSEPMFGGRSELEQLKLIFTMLGQPSDDIWSGFSKLPHAKSINTSQFPLYSSLRQHYKILTESGIDLMAKLLTYDPKKRISCVDALKHPFFKESPLPKHPDLFSSFPSVAAGEQRIDYNRSRSPTAPRAHNSQGKVAGYDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Y3</accession>
    <name>I4Y9Y3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959300.1">
        <property type="nucleotide sequence ID" value="XM_006959238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Y3"/>
    <dbReference type="STRING" id="671144.I4Y9Y3"/>
    <dbReference type="GeneID" id="18474200"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60841"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Y3"/>
    <dbReference type="OMA" id="ITWVGYK"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="564" mass="60899" checksum="D9F614B6506DC2B6" modified="2012-09-05" version="1">MGANDVANSFSTSVSSRSLSFRKAILAAAICEFLGAILVGARVASTIKDSIIPLSNFPTVGFQMLGFACVSAGSSTFQIFATRLGMPVSATHTVIGSVIGVGIASGGAQSVNWKWDGVGQVFASWGIAPAISGGFAAIIFLITKYGILKRKNSATLAFIAAPIYFFVVAAILTMAILWKGASTVKVDELSTGTLVGSIIGTGAAVALLSILFFLPYVHCQVIKKDYTIKIWHIFLGPLLWFRKAPEDANDNTLAVPDYYAGHREEDWSHLDGQYKKPETIDAAEECRSISQKSVHSQPQADANHPSKLSEEVEKQDITGRPPKPNYHPIEGAWIEPWNIWIGLRYNLLPFLNYYLFGGLRTDIHQMQKSGSDKTQARIRDMHAEATQYDNNTEHIFSFMQVMTACVASFSHGSNDVSNAIAPLAAVYYCWSTSEYSGEKSEIPVWVIAFGGIGIVIGLATYGWRLMSVLGNRLTLHSPSRGFSMELGASITVILASQFGIPVSSTQSITGATVGVSCCSGTFKTTNWKALAFFFYSWCITLPLAGIVSGCLFGIIANAPGFHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAP4</accession>
    <name>I4YAP4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_64932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959022.1">
        <property type="nucleotide sequence ID" value="XM_006958960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAP4"/>
    <dbReference type="STRING" id="671144.I4YAP4"/>
    <dbReference type="GeneID" id="18474972"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64932"/>
    <dbReference type="eggNOG" id="ENOG502RZSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026393_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAP4"/>
    <dbReference type="OMA" id="YYARDYS"/>
    <dbReference type="OrthoDB" id="3345970at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="68256" checksum="CD22413076EE5B56" modified="2012-09-05" version="1">MASRSTVNLNNYEQQDEEAGEEYAMLPNSSSRTPLNGTRSDGYSPLSGTAAASKKPWGNKRKALIFVGLSFVFGFIIHIAYTLATDFKSNRSDVSGPSKAILDNENLSSDPMSFVPGHSKNKSKQDLKDLVQSTNGYFIRDFSVWLGWNNIRYIIESSLLHAQILNRTAILPGYVYARACEFDQATCGAFAEQVNRGKATGDPEWNDLPESEQQGWKIPLGVMVDLDHLSETYKNFMTLDEYFDLEGLSADVMATNGQWQQHYNNGNKYHAIENDQWDPPNIVRVDIVGEKPEADPKAVPVGLTAADVEEIFGEEVLIDWPYLRVALQARGFKMPEDSTGALAALGYRLLYTYDQIQGMDFLKSPINPITQVAKESSLRGLYEDGYNVKSKLFHVKGEIHLYRRAGSLRFTTPEARDNFKEIILEYLKPLPRIYQVATIVDARMREMNQGRAWASAHMRRGDFESHGWAMEANFKDHLARIMNHLDSGIDVINKKPKYLHKIPGEDTLPGLPKKGDHFYIGTDERNTTNLEYLRSQGGVLLSDILTPTDRDEIGPMGLFTDVLALLDQVIMSEGAYFYGHALSSVAGGVVNFRTAAGYDEKCTLVAFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ4</accession>
    <name>I4YAZ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958810.1">
        <property type="nucleotide sequence ID" value="XM_006958748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ4"/>
    <dbReference type="GeneID" id="18474952"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64720"/>
    <dbReference type="HOGENOM" id="CLU_2777829_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAZ4"/>
    <dbReference type="OMA" id="AHPHLMH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697667" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="69" mass="7244" checksum="9F4438E3B6664AC4" modified="2012-09-05" version="1">MKALCILIAAVAVATASPIQYKAFVPVGLGKNHINSTNTSHPIHPHNATFHNATHYAPINVGLPGSSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB94</accession>
    <name>I4YB94_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nop52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_54618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958591.1">
        <property type="nucleotide sequence ID" value="XM_006958529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB94"/>
    <dbReference type="FunCoup" id="I4YB94">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB94"/>
    <dbReference type="GeneID" id="18472681"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54618"/>
    <dbReference type="eggNOG" id="KOG3911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022876_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB94"/>
    <dbReference type="OMA" id="GFWETTV"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="275" mass="32365" checksum="DF929185EDECDA08" modified="2012-09-05" version="1">MDNDKIPPLGKYLASNEKRERDKAIRNLRNFLTSKNSNLDDLESAKLWRGIFYCFWMSDKPLVQQKLAWDLSNILLEIPDVDNCWNFYKGFWDELIREWSGLDRYRLDKYYMLIRKFLQAAIKVCVNDNFNSLDTFNSILLNPRGASPLAYEDHRVPASLTYHMSDIFTDELNKALADTDESYEIPLAQLLKPWSQLLAHTRNNVAYKRVFEGVITKLIDEDDEDIENIRKCVNLKEARKLISNILFEEASKSSANPTNRRKLYEFVDELRMEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBM3</accession>
    <name>I4YBM3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958712.1">
        <property type="nucleotide sequence ID" value="XM_006958650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBM3"/>
    <dbReference type="FunCoup" id="I4YBM3">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="18474020"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60548"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781193_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBM3"/>
    <dbReference type="OMA" id="NIEDPLW"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39486" checksum="69DEBE8DD5553809" modified="2012-09-05" version="1">MLDFVIEQIAFDRIIAAVAVVVSLAFIRSYAGGVKNDHRRDLHQRTVILAGLPSSVLTCTLPTLAETGATIIILHPRPLELVAIINAIRLRFTDAEIFAEKCDLNDVESVKEFSDNWNKSERTPTGPSNTIESGQIRRIDGVIFSTDYEDGVVITPNQEKRDAAAHLLLLSLIPAIAHSPNSRDIRVIRLVQPFYTAGTLKVVNSKMTNINLAGIQALRGIALSRYLQSEIDSAKSQNVVPEVDKTRIEKSNVSCLTVCPGFVREATVWPLFSQYGIIGKLLYFLLLPVIYLITKSASEGSEVITYALMKEKPGKGMLYRDNKLVGLPKELQIELSNIDNLKSTWMYFESKLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV5</accession>
    <name>I4YBV5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958477.1">
        <property type="nucleotide sequence ID" value="XM_006958415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV5"/>
    <dbReference type="GeneID" id="18475511"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69019"/>
    <dbReference type="HOGENOM" id="CLU_957137_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBV5"/>
    <dbReference type="OMA" id="GIQICWQ"/>
    <dbReference type="OrthoDB" id="3365886at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="291" mass="32529" checksum="7BD56BBBF65066A1" modified="2012-09-05" version="1">MSFYNQDSSSSDDDIQICWQASQSNLLHQLAGTQMTRLPPPPPPPISPPKSSPAPLSRKSRSFTRDRSQQFRRTRSSRSHVAIPQPAPIDDVGTDRDDSECESSKPKRQKISKQSTELDILIEKVSARLKRERSSNSSVQECQSSYTTDSIPPQPQNSTNTLSSLSSQSTRIPRQIATRTIPSQTANQHFKAPERVHQNSNFPPQAQVRAEGKASCIPAKRERSPEMALPKVKHEYSPDTIEAKPTILEDDDRQDIKPKQEDKIPSSDGADYSCGEDFDVDILEQVCAQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC52</accession>
    <name>I4YC52_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta alanine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_38551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958566.1">
        <property type="nucleotide sequence ID" value="XM_006958504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC52"/>
    <dbReference type="GeneID" id="18472070"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38551"/>
    <dbReference type="eggNOG" id="ENOG502QPR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_2_0_1"/>
    <dbReference type="InParanoid" id="I4YC52"/>
    <dbReference type="OMA" id="CSSGVWA"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="432" mass="48175" checksum="6EC1DEB8D89ED20D" modified="2012-09-05" version="1">MQYETLKINGPRLNATLQETCDEYGTDHRYGDRREETGMCRLALTDADKGIRDWLVNEVTKLGCEVRIDKMGNMFCIRPGRLNSSPIGIGSHLDTQPMGGRYDGILGVQSALEILRTLNETKYETFHPICLINWTNEEGARFPNSLHGSSVYAGILPLEQAHSLKAVIGEGVSTLDELKRINYHGIHECNYKANPLKAYFEYHIEQGHILDESENQMKIGVVHQATCYRWFTLRIKGRESHTGATPFDRRSDSVLTGAQIILTSTEIAKRLEGLFSTGIFEAKPGSVNTTASYVEMSVDLRHESNEILDVLESEVIKTSVDIAKQMKCELEWEKSIRSDVRQFDSEVVRSITKAATDTVGDDKHIPMRTWAGHDCCAVSSTGIPAAMIFCPSRDGITHNPREYTSSDDCATGAQVLLQAVLDYDCKMASRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC65</accession>
    <name>I4YC65_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_18341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958235.1">
        <property type="nucleotide sequence ID" value="XM_006958173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC65"/>
    <dbReference type="STRING" id="671144.I4YC65"/>
    <dbReference type="GeneID" id="18470763"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18341"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="InParanoid" id="I4YC65"/>
    <dbReference type="OMA" id="HVVNLCG"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="116" mass="12746" checksum="3337E12E4E6863EB" modified="2012-09-05" version="1" fragment="single">LSHGADVNVKDRANQHPLHRAATIGNNNLVKLLINPDDGKERAKTRLNTSDRIGNTPLHLAIESGHAATAVLLIEAGADRERQNYDQQTPEEIEGVGGQEHRRLLEYIKNACGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCA1</accession>
    <name>I4YCA1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958290.1">
        <property type="nucleotide sequence ID" value="XM_006958228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCA1"/>
    <dbReference type="STRING" id="671144.I4YCA1"/>
    <dbReference type="GeneID" id="18473895"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60336"/>
    <dbReference type="eggNOG" id="KOG3300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119720_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCA1"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="124" mass="14238" checksum="E9CA44D04EFC61A8" modified="2012-09-05" version="1">MDYLRGKQDLPPPGGFEAIKYKRSLPVKGPSGAVIFGTIFGICTWGFYKLGQGNLEMRELEREKTWSRINIVPLLMAENDRDIYRREKAALAREESIMKDVKGWEVGKSVYNGKRYNTPSMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCM2</accession>
    <name>I4YCM2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_18408</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958237.1">
        <property type="nucleotide sequence ID" value="XM_006958175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCM2"/>
    <dbReference type="STRING" id="671144.I4YCM2"/>
    <dbReference type="GeneID" id="18470765"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18408"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="InParanoid" id="I4YCM2"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="7"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="333" mass="37432" checksum="F165F5DB4B475E4D" modified="2012-09-05" version="1">MEGPANLLRDKHVEYIVQLGKADNTLGFHLTEHLRLNGIYWAVTCLALLKRIDALDRQQTIDYVYSCWDNKLGGFGSHPNHDSHMLSTLSAIQVLAIHDAIQESGIDTDKVINYILSLRPKNEGFFTGDEWGESDTRFTYCAVSALSLLGALHKLDEKENGVAIKDRIVDWFKQCMNFDGGFGNNISAETHSGQVFTAVAALAILDRLDIIDRDNLSWWLSERQVESGGLNGRPQKLEDVCYSWWVLSGLSILHRLHWINKEKLMSFILSSQDPDNGGIADRPGDVADVYHTLFGVAGLSMMGYPDLEQVDPVYCMPVKTIERMHLTKSYTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT6</accession>
    <name>I4YCT6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958085.1">
        <property type="nucleotide sequence ID" value="XM_006958023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT6"/>
    <dbReference type="FunCoup" id="I4YCT6">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCT6"/>
    <dbReference type="GeneID" id="18471473"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32360"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="I4YCT6"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="23292" checksum="9ADFF8089A87B5EF" modified="2012-09-05" version="1">MPAPKKTVLLKVIILGDSGVGKTSLMNQYVNKRFSNQYKATIGADFLTKEVVVDDRVVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNAKSFETLDSWRDEFLIQASPQDPVNFPFVVLGNKIDMEDSKRAVSQKKATSWCQSKGNIPYFETSAKEAINVEQAFQTIARNALVQEAEVELYANYPDPIRIDQESSQSYGGCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX3</accession>
    <name>I4YCX3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958118.1">
        <property type="nucleotide sequence ID" value="XM_006958056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX3"/>
    <dbReference type="GeneID" id="18473844"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60259"/>
    <dbReference type="HOGENOM" id="CLU_2279632_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCX3"/>
    <dbReference type="OMA" id="SAHFFIL"/>
    <dbReference type="OrthoDB" id="10501561at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="113" mass="13615" checksum="1B9615F51322D9A9" modified="2012-09-05" version="1">MNNEVTRVARMERDLFKQFSAAVKSFESMLHVKTSHRVYLSYQDHLVHLLKLIAAYHRAGLLSNDFFVLMRESFIVVEEACYTRPDSPEHHKNFFKEFRTVIEEYRKMYKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX4</accession>
    <name>I4YCX4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958119.1">
        <property type="nucleotide sequence ID" value="XM_006958057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX4"/>
    <dbReference type="FunCoup" id="I4YCX4">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCX4"/>
    <dbReference type="GeneID" id="18471478"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32388"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCX4"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="89"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="439" mass="49981" checksum="C40EE81B0BD0A5F2" modified="2012-09-05" version="1">MTNKLKQHEIGRQPEIFYQQNLNKSRFHVRRVLMLSLRKESEIMARFQHRFRRKWLDNYMLWSSFLGTVTFFILLIPIPYFWGHSDRGRALLQTLAASVWITCLMKDFCCVPRPYSPPVTRITMGTSHLEYGFPSTHSTTAVAQALVLNNWLSDATADGSVDPFTMSVLRTLLIIATSSVVFGRFYCGMHSALDCFSGVITGTMIYITRSYIGPYYEAFIEQSTFLTPILLTILSLYAIHAHIEPAEDNPAFEDSVAFISVFLGNGIGEWIACNYGFHHSTYFVTKLTGWEWCLASLFKYPLGVGLIFLTRILCKPIMQAVLPPLFRLLHKLVKLPNRKSYVPATEYESYNPTSDTLNPIPSVVDLAQLKHVKETHNSKQATEIVGEERPTISQTTHRKFSPRHYDADVMTRVVSYAAMGFVGTIIAPIIFEKLGWGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD02</accession>
    <name>I4YD02_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCA2 OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_37947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EIM21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006958084.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18472036"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37947"/>
    <dbReference type="eggNOG" id="KOG4751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045563_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD02"/>
    <dbReference type="OMA" id="MAPWHAK"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
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        <property type="entry name" value="BRCA2_hlx"/>
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    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
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    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="1">
        <location>
            <begin position="85"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49614" checksum="5DC98DE2F4E3F31A" modified="2012-09-05" version="1">MNPQLAQGCVFENGFNAALAYEEMKKRGCTYITMRWVKNHWRFIIWKLSAIIRSCPTELTRWTSEEVVRQLLYRYEREHNLAERSCIKRIQEHDSSSTRPMVLCVSGIISNNIIELTDGWYPIHAQIDECLSRALSRRRIKLGCKISIIGARLLSGYEGTDVLDAVGTCNLSITANSTSLTRWDEKLGFQPPLTGFVSTIGSLSFDGGLISLLDVVITKIFPLAYIDSEQRANDHAWDEVEEMKRLQEEQNRINLESESDSHKRMKEIKYIEDILMRLDDATSNIAMSRNNPDEIDADDELDTIIAITDSKERNKRIRSLNGSIAVNIAISARERMMKIAKQPNENKAERRKVRNFRVIRIEDYSNGIKAKKSAQLHIWDAVTLNTQLTEGQRFKITNCNPTRQKSWPSKGQSGEVYLSTRRNTRFYNVNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD21</accession>
    <name>I4YD21_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF382-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_37969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958164.1">
        <property type="nucleotide sequence ID" value="XM_006958102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD21"/>
    <dbReference type="FunCoup" id="I4YD21">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD21"/>
    <dbReference type="GeneID" id="18472040"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37969"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="InParanoid" id="I4YD21"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="479" mass="54373" checksum="446F59AE94FACFE2" modified="2012-09-05" version="1">MKNEWLYSDDDEDEDNAAKEEEQLSKKKLRRINRLSVAELKSLVAKPEIVEAVDTTSRDPRLLVHLKSYKNTIPVPSHWSQKRGFLEGKKGIEKPSFQLPSYIADTGIGVQQDAVKEREAEMSLKQKTRQRVQPRMGKMDIDYQKLHDAFFKFQTKPPMSDYGETYYEGKEFETYVKERKPGEISTELKEALSIPPLAPPPWLIAMQRYGPPPSYPNLKIPGLNYPIPEGAQWGFHPGGWGKPPTDEYNRPLYGDVFGVIPKYNPDAAEEIDKSLWGEILSDEEQEDSSEEESESEEEEEEGADEGVEEMDEEAMDGMETPSGMASVATSVPGGGLETPAFTDIRKGGRSGAESVVDSKPRELYQVIPEKQTSVDGLMGSERGYDFQTLGEESNNTRKRKTGDVELAIDPEELANMTSEEIKQAYEEQRRSSTNRVHVPGADRAEDFTDILQEEQGKRQKREERRRADKETSNKEKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD23</accession>
    <name>I4YD23_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958166.1">
        <property type="nucleotide sequence ID" value="XM_006958104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD23"/>
    <dbReference type="FunCoup" id="I4YD23">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD23"/>
    <dbReference type="GeneID" id="18473859"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60278"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009108_2_0_1"/>
    <dbReference type="InParanoid" id="I4YD23"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="592"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="725"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="815" mass="91451" checksum="326038AE2A8C24D6" modified="2012-09-05" version="1">MNSEAENPVVWRRQNSYNLKQNKSDNNIPPQQLIPRANQQQQQQEQQSDLNLANILHYLQSEWRRYDRDRNEWEIERAEMRARLALLEGEKRASDNVKSDLLRRVRMLEYALRQERAKYIALSQPRSTSPKSANSGESINEKPGVSAIHPSKKASLKDNDGSDSQKSDDSQTLASSNTLLNNHNSNLPQWLRSTNPSKDTKTRAKSRQYLQQCLEEITYLTHPTTLNPLTARPHKDADGFQVEKLPQSVPMESSSPSNSNDNNNDNSNNQPMEKLDEQLSNSLSDSVSIKESPAGPIVSQPIIETQESVQATLAPPTGPSSPPAVTTNDLIRKDENVEEQTEQVDQNVEQQPEQTVQNDKNDRELEQRIPENENEQGPEDDQDDQTVIDDSDDHDPENESETTFTQTNEEKDTNQSIELKEQTDNLVPPENPLNAQLPEEQVKPEEDKPSQSAIHLTTTVDDDNDNESIRSATSSMSSSQGLWKSWKTLKSHIDPVRAVVFKDINPEQALMMTAGDDTVLKYWKIPKDTNSIEEIQPIVNLRGHTAPITSIAVSKTKNVVYTSSIDTTIREWEITDQDGDLLDLDKLIGKVYEGHTNAIWGLACTSTGKLISAASDSTIKIWNEKTGELERSINVERPCSSVDLYEENDEMKLVVGLTDKRAIMIDLNKSDENYTEFLVDDAQTDNDTSVQFNDLVIDGDRMYSAHEDGKIRLWLLPGGQRLETLIAHLDSCTAIAFQPNTRIMASASHDCSIRFWTTDKFSQIHSPGVAHAACVQECGGHKKVFSEGVNQIAFTLDGDLFASAGGDGNVKLYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD31</accession>
    <name>I4YD31_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_60282</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958174.1">
        <property type="nucleotide sequence ID" value="XM_006958112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD31"/>
    <dbReference type="FunCoup" id="I4YD31">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD31"/>
    <dbReference type="GeneID" id="18473861"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60282"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="InParanoid" id="I4YD31"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="392"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="528" mass="58095" checksum="F03B678BD6ABB6F3" modified="2012-09-05" version="1">MSFESLGSTNTFQWLANLGTEQNTENKHFLRKTSIIATIGPKVNNVESLTSLREAGMNIVRMNFSHGSYEYHQSVIDNVRTTVAANPDHRPLAIALDTKGPEIRTGLMKGGDDIKVAQGHEMYVTVDPAYAEACDDQYMYVDYTNIVNVIEPGKLIYVDDGILSLLVLAVEGKNLKVRCLNNGVLSSRKGVNLPKTDVDLPALSEKDRNDLQFGVKNNVDIVFASFIRRADDVKEIRKVLGEAGKNIKIIVKIENQQGVNNFDEILRETDGVMVARGDLGIEIPASQVFMAQKMMISKCNIVGKPVICATQMLESMTFNPRPTRAEVSDVANAVLDGADCVMLSGETAKGTYPIESVKLMGEVCLLAEHALANGKIYQELRALAPRPMDTTETISSVAVSAAIDQGASAILVMSTSGNTARLLSKYRPRCPILCVTRNEQTSRQLHLSRGVYPIFYNESRPQDESNWQVDVDNRIRYGLKKALDLGIVEKGTTVLAVQGWKGNAGHSNTLRILSVPENDHEYALHPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD99</accession>
    <name>I4YD99_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">allantoinase</fullName>
            <ecNumber evidence="4">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_50992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="4"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957753.1">
        <property type="nucleotide sequence ID" value="XM_006957691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD99"/>
    <dbReference type="STRING" id="671144.I4YD99"/>
    <dbReference type="GeneID" id="18472540"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50992"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="InParanoid" id="I4YD99"/>
    <dbReference type="OMA" id="HFNEPGR"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="58"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="44562" checksum="4E11EA45AA3C1EEF" modified="2012-09-05" version="1">MKIVNKFAAEKAILPTSYEPQPATIQVDDQSGKIFDVFGGIRNDKEVGDVVKVDEKDIILPGLVDSHVHINDPGREEWEGFDTATQAALSGGVTALIDMPLNSIPPTTTIEGLDAKKDATVGRIHSDIGFWAGSVPGNEEHLEALLEQEGVFGFKSFMIDSGVDEFSSVSPEDIKMAFKELTDVAKRGKNVTMLFHAEKETKKIDEKIEKNIEGKSTQEYSTYLLTHPEEYELEAISTLIEIMKEYPDIHVHIVHLSTAKALPMIRQARADGMKLTVETCFHYLYFNSEEIPSARVEYKAAPPVRDSANNQLLWKAIKDGDIDLITSDHSPADAETKKIDKGDFLDGWGGIASLGLGFQALYTKIQKGGGLDFPIGQLVELTSRNPAILAGFDDRKGSIKKGLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE2</accession>
    <name>I4YDE2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957794.1">
        <property type="nucleotide sequence ID" value="XM_006957732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE2"/>
    <dbReference type="STRING" id="671144.I4YDE2"/>
    <dbReference type="GeneID" id="18473752"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60115"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022618_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDE2"/>
    <dbReference type="OMA" id="ACSGCRY"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="278"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="476" mass="52391" checksum="A1F648815B4CFEEF" modified="2012-09-05" version="1">MSAYTAGHNRQPTFEEVTTPIPTSPVRLMTPDTLHPNDSVSNVHTNYSTPPPVDPFRSVSPSAYSQSTHTPHPYFAVPINESRTPPPALPEYTRDPSPYAPGTRAAPFDYEDNDPYKHPAEAGPTSYFFNNPTNRLSGDWLSHSKHRKTLGLLGVLPWFHYRRSIEQQIEDRRRGIHRQKWPILSIIIGIAIIIITAFQIANNKNETGSVFASGSANPMGGPTAANLIHQGARFRPCMTETNLSVQLPSFRDPDNPTSETMPLYELCGFGMSSTEEPSQSFRFVLPIFLHSGILHLCINLFALLVLGAYAERVLGSLAFIIVFGAAGIFGNILGGNFAQVTTPSVGASGAILGLIAVSLVDLLFHWKLERRPGLLLTIHIIELIVMFFIGYIPNLDNFAHIGGWLQGLLLSVFFIPVISPTKKHRIVTIILRLAALAGSIVLFIVLAKNFYTDDPSDGCTWCKHLSCFTNCDSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDG9</accession>
    <name>I4YDG9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_32208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957820.1">
        <property type="nucleotide sequence ID" value="XM_006957758.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YDG9">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDG9"/>
    <dbReference type="GeneID" id="18471442"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32208"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001071_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDG9"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1923" mass="215049" checksum="CF17D4D6DB12ACB3" modified="2012-09-05" version="1">MSNHISAFKPDNYNKLYKFLLEIFINQSNIKDLYLELNKFNLQNPLDLPKPNNAEKSELENGNATISGVLHKVNKDFINQALQLSSTLNISHHLASSLLQHGMQRCSRYQTTPLETAVILFHSERLELVRCLQLIINGSTDPNLQQSGLMDVLNNFTVQLIQNNFINTLISSLKSLKNPQITSTGLNDAVTAESINFITLQRQELAHLLYLFAFNQQMSQSDITSVINYASTLDFEDSITPYILSTLLAAFNFNCQDLSFITNTLRTSSSSNWLNKSFKAVFSLRFALFIVSSFQFNPNLASKATVTEDDVEKIVLQSINDDAFLHLQQVLINATESESPINVDFKPHLLFQLDMFITQLITTLSPVLRKLKHREEDLILASSRSRSFNIDASPSTRQDLAQLYFLIALLYRNTEPESALKFWVTDKDDYRLFAFLRWSAEARTPLMVHSLFEMIGSLASGTQCATYVYEFLSGNTEMNDNSLCSWNALFGALDFYANNLNQNQPNGESQARANEIPPEEVDLLKAFLFVLKQVVGHSSVARAALIDNPTYKPIQTLFSLLACSIPVDLKSSLFDTLASFASAIPANIIGQGSSSIATENAKKIWVMLESSQILPTTRRKQPSPLTGILAELEEIESAAGTYPISASFINFLNNLIHTPAKSLTLRKGIELDSLTIPNGLGANHRVPGIQPFVNFVVDDIFLKLPHRGFKYLTERWKLTETSLCFIEKCLSTYDLSQLFVEGTINVGSVNEVVANPSEVSLCSLILHPGFNVLIQFLSGGPILKEVFNLIGTGIDAILDNRFKTPFYAKSIQRCLRIIYRIMSIQSMFLEVLLPLLRQQNNIIPGIGKIDIPSALSTLDQHLLFAHDAVIQIALYVNAIDEETSLLAVKTISAIAKSTYFSTADGFANHYKRKMNRLTGIIDSSDESLRILSGFVRLLEVDAPEDTDTIDDTGIETLLNSSTDIDNDNIHLTQATRSVILDLLIENTKSSAPSPNIAHFLLGFNLQSSSPSEIEIEDPLNQSSKVSCLHIIFSLLAQGVENDDDDVPLFINHPILAEKCYRLIYQLCTSELTSNATLRYLRLHEDFFYKQLVALPIKQIPISSQPPLGVARFGDGGMIQTSSSSLASFLRFRAWLLDTVALEIHALTNSGQTQRVTKLVDVLFSESNQVLDIEANEFGEVVETQDIDQSLAKILDIYQSLDLDYIDEGVNAENLSVSFFTGLDLSTCLKTDDNGSVIYDFRALLSLLGAARRHLQKSGVIASPTQYEQVKAETQQILEFLASDNRRRQVHHARQFNLEAWKRILDIVCAKCFDTINKDRRETVLLNILQTILPKLTSMDIAPATSELLCGATLSLITKLRTTFSNLSEEDDVDQRLYVMPNDRLLSILKQVIEVIIKPGSTVIVRGNLYSVLHNYLQIVNLQSRAQSGLEVDSQLVLDMVHDKLIPIICRDAVDGSEVWKTVAFSVLDGLAALSLKNNSSASLDIMVKHGFLRNFVQSLKDTEDVLINIVQSDPESLNPLYVFEAKTAMLLRIAQDRKGAERLLDAQIFTVLAQCEFVSCRPSGEESLMDYESFLPPATERYHQLLLPTLQLASTVLSSVGVTSAVAAKEALGFVYAHREVFLEILRDNPTLTSLALVQEHHLIVCILHQVKSVVSDDELISPSGFGAFHTAILNLSTKYMTRANWINRVVPFTDTEKEDSLILSKGGESSKFAIMASITVENVNEWLLNYLTLTRSTSSFRPLLLPLFPQVRDGQDLHQASSSSPTLGQAITGLKELVSLFHGTLFDFREHQFKIQQTPSIHMEIMLSSTIKVLKSRLTKIEMMLLLIWRHAEFYVKLQQKPQMQQSLSASLKPYGNVDSNATAREISQLILPILSKLDGIELTSDMIQANDVRSRQAFLQIISRRIREAILYNQTDEAMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDH0</accession>
    <name>I4YDH0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_37478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957821.1">
        <property type="nucleotide sequence ID" value="XM_006957759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDH0"/>
    <dbReference type="FunCoup" id="I4YDH0">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDH0"/>
    <dbReference type="GeneID" id="18472018"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37478"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="InParanoid" id="I4YDH0"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="17617" checksum="F2C00C90386377AB" modified="2012-09-05" version="1">MATVVQLKTSQGDIDLELYVNHAPKTCNNFSQLVQRGYYNGVVFHRIVQDFMIQGGDPTGTGRGGTSVYGGKFEDEINPELRFTGAGILAMANSGPNTNGSQFFITLSPTPYLDGKHTIFGRVLRGMRVVQRMGNVVVDKADRPIEDVKIYNASIQQMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL3</accession>
    <name>I4YDL3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957859.1">
        <property type="nucleotide sequence ID" value="XM_006957797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL3"/>
    <dbReference type="GeneID" id="18473774"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60150"/>
    <dbReference type="eggNOG" id="ENOG502SCA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4YDL3"/>
    <dbReference type="OMA" id="TPIMGIG"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987071" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="10870" checksum="D3EE599DC53C676E" modified="2012-09-05" version="1">MIAQTVFAAALVASVSAGWESKTGSCNTGKLSCCDTNKKVEKSTGEESGLLHTGDILDQVAIQCTQVPLLIGVAIEDECKNTPVCCEDTEQDGLVGIGCTPVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP2</accession>
    <name>I4YDP2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957888.1">
        <property type="nucleotide sequence ID" value="XM_006957826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP2"/>
    <dbReference type="STRING" id="671144.I4YDP2"/>
    <dbReference type="GeneID" id="18473780"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60159"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052897_3_0_1"/>
    <dbReference type="InParanoid" id="I4YDP2"/>
    <dbReference type="OMA" id="HKEEART"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="23400" checksum="6109B96D20B47F15" modified="2012-09-05" version="1">MPAKQSNNHPSYEEMLKECIAEENDKTGVSRQTIKKFLASAYKINPESKMTAHFLSQSLKRGIENNVFVCPKGITGKVKLAPKKRAGSDSSESDDDKVKPKTKRVARVNQSVAPKKTVTGTTASGRKIVTTSHVNEVKKPVDSKKRTSSTTRRVAAKKTPATTAIKKATKKPATKKLTEKAANKPTAKKSTGKKPVAVKPLNGKSTTNRRSSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDS1</accession>
    <name>I4YDS1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957915.1">
        <property type="nucleotide sequence ID" value="XM_006957853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDS1"/>
    <dbReference type="STRING" id="671144.I4YDS1"/>
    <dbReference type="GeneID" id="18473789"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60172"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_1_1"/>
    <dbReference type="InParanoid" id="I4YDS1"/>
    <dbReference type="OMA" id="WSQAGPN"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="562" mass="63433" checksum="7DCE85BF1CDA4C82" modified="2012-09-05" version="1">MSATQVITKKPRTEQNIKLNKVQDDRLPVTLLSGFLGSGKTTLLERILKSKDHGLRCAIIVNDMSSLNIDAATVENHKLTKAGEKMVQMQNGCICCTLREDLLEQIALLTEEKVFDYLLIESTGISEPMQVAETFSFEFLEEAVKIEESLAENSTKDKATQSKMANILAKGGLPKVARLDTTVTVVDALNVLNDFNTTDFITDRPQEVGQGELDESDERNVTDLLVDQIEFADVILVNKCDLATKEVVTKVTTLIKTLNPRADVIPTTKCDTDLSKILNTHKFDFEAAVTGAGWLQSLREMLPIEVKSADGTVQRHAPKPETEEYGISNFVYKRRRPFHPLRLWLLISKYWVIIQDSLEEGEEGEDDDEEEGMEDDKNEDANEEEEVNTTEQPQLDPAARLRDKKASIFAPLFRAKGFIWLPGREQMGEISQAGVMMTVGGGNPWFVSTPESEWDVDGLAVKAIKADFVGKYGDRRQEIVFIGGGEKRMNQEAIEAEFDKCLLTDEEMKDYDEAMQIPYEDDKYERLQELFEDGFEEWGFPGEEEEDEEEGHSHGHTHNHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU7</accession>
    <name>I4YDU7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_51119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957939.1">
        <property type="nucleotide sequence ID" value="XM_006957877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU7"/>
    <dbReference type="FunCoup" id="I4YDU7">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDU7"/>
    <dbReference type="GeneID" id="18472546"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51119"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="InParanoid" id="I4YDU7"/>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="34070" checksum="20BD285B9C1DD03F" modified="2012-09-05" version="1">MSFTESAPPQSIETGHQDVIHDAQLDYYGKRLATASSDRTIKITDITDAPSSTYTNSNAVILQGHQGPVWQVAWAHPKYGSILASSSYDGKVFIWKQEGANWTRIKDHTLHTSSVNSISWAPHELGPTLACASSDGNVSVLTFHNDGTWDASMLAAHKLGVTSVSWAPASSNSNITAPGSANASALSHKLVTGGCDSLIKIWSLNSETKQWQCDDTLQTHTDWVRDVAWSPNVGLSKQYIASASQDKTVYVHTQQIANGEWSSTKIDYDFKDTVWRLSWSLSGNVLAVSAGDGKVTLWKENLEGVFELVSDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW1</accession>
    <name>I4YDW1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957953.1">
        <property type="nucleotide sequence ID" value="XM_006957891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW1"/>
    <dbReference type="STRING" id="671144.I4YDW1"/>
    <dbReference type="GeneID" id="18473797"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60181"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326303_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDW1"/>
    <dbReference type="OMA" id="HNDETIS"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="875" mass="99464" checksum="6D4127A9985A48CF" modified="2012-09-05" version="1">MLNEKYNNYFKDLIKNDNLNKNELFRKLYKHSTSHSHLQHFQHLIRVDDGVEELKELSNIDDDLISNYYTLLKSQRDEKLAGELKRELRKSHLNPLNDKEISVLLKEYNDKLYIRFLSIKTKQGDSVEDIFELGIYNEVTDAIVIDQLTKTSNHEYKFRLGEHAVKHSNNLDVHLDFLDLLLKHPPISVSEVLYKTYTIITKTHQTPKSGHYNVKVVKFQDSMLNIWNYYNKPTSLIPVITDLLISCQQYTFLSQSNFRSLFYLNKDIPFTQDLAIRSFDIYYHLVHKSRETDAKNVNIQLRSLHGDETIDPSSIMDLDTDGVFYQTIYDAIPVILKQFKFDLAKEVVKLVDSKEGDLFYAKKCYLEGLLLAYEAENQWESNNRESLFGESLERIHKSLSLDPKNTTTLKLYSWVSDQVYNTDTAISALREALTIDSSDWEAWLRLANLLSAKDTKGALDVVQSALDLSEGTSSRNDPLAPETVSSIERAHLIMKLLILENLLVEETIGVDEALSNQTKLFGYYSNNIPKSTKMTKLMEEFSFYHPSERRVGKRTSDDDSAFNYPLKLSSSEGALAKRRHGLESSSSMVSQQSTNSSKQSSRRSRLHVPVPHISVGSALGKFRSKKHPRSVNGTAPSIQTAPNSDLDLNKNLPRIRVSSVPNEKAKQNATNGTVDQNKLTISSSASNVGVDVQDYEHRELNLLTELWLMSAASYRRSGDLEQAANALNMAEECGPTYCGVYVELAKQCVEQKDLKSANEALIKAQFLAASSASESERSYQIAEYEYASSLFNLSDEVNEVHPNLDSNRRLDAVEGLLETLLRSSHFIHRNYPGAHYMLAMCYKSRNRLGKVKGSLESALKVERTVGVLSLDGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY3</accession>
    <name>I4YDY3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase omega-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957973.1">
        <property type="nucleotide sequence ID" value="XM_006957911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY3"/>
    <dbReference type="FunCoup" id="I4YDY3">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDY3"/>
    <dbReference type="GeneID" id="18473804"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60195"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="InParanoid" id="I4YDY3"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="155"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="35186" checksum="6980BFE8B3EED671" modified="2012-09-05" version="1">MSTSISNWASKDGEFRRQVSSFRDEIKAGGKFEPENNRYHLVVSYACPWAHRALIVRSLSGLEDFLPYSVVHPYLGEKGWSFDKDFEGATGCTIEGVDATHLRDLYFTAEKDYNARFTVPIIWDKKLKTIVSNESSEIIRFLNDLKPDVGGDIYPEHLRKEIDELNGWVYDTVNNGVYKSGFATTQEAYEGNVKPLFESLDRLEKILSDGRDFLIGGQLTEADIRLYTTIVRFDPVYVGHFKCNLGTIRHNYPHINTWLKKLYWKNDAFKSTTNFKQIKFHYYNSHRHINGTGVVPLGPNPDIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF7</accession>
    <name>I4YEF7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957604.1">
        <property type="nucleotide sequence ID" value="XM_006957542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF7"/>
    <dbReference type="FunCoup" id="I4YEF7">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEF7"/>
    <dbReference type="GeneID" id="18473694"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60029"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEF7"/>
    <dbReference type="OMA" id="WNDAYFN"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="336" mass="37593" checksum="9CBB7D37CA7E26FE" modified="2012-09-05" version="1">MTEKSALPIVLGAMTFGAKGKEQARVHDYETVQEIIDTFGEHGHKEIDTARMYGGGTSEEYLGHLQIHRKYDLSSKIFPFDQSSNALSGGKNSVKHTAKDIEEEIDTSLKNLGVKKLKIWYLHAPDRSTDYLETLRALDVQYKQGKFELLGLSNYASWEVAEIATLARVHDLVKPSIYQGVYSAIHRAVEPELFPALRKFGIGFYAYNPLAGGLLTGAVKLGGSVEEGSRFDENRHQGKLYRARYFNEGYSNALNEFIKLATKYSLSPAEVALRWLTHHSFLKKESGDAIIIGASSIKHIKSNLDDLDKGLLPEELAEEVAGLWTTLKPYANSYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV6</accession>
    <name>I4YEV6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957173.1">
        <property type="nucleotide sequence ID" value="XM_006957111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV6"/>
    <dbReference type="FunCoup" id="I4YEV6">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEV6"/>
    <dbReference type="GeneID" id="18471362"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31742"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="I4YEV6"/>
    <dbReference type="OMA" id="FASMPSW"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="30822" checksum="BD60BF0D58FC2B88" modified="2012-09-05" version="1">MSTPRVWLITGTSSGLGRALVETILAKGETVVATLRKPEVLKDLSDKYDQSKLLVLKLDVTNSQDIDDVFSKIKEVYNRLDVIVNNAGRGIVGEFEATTKEDGKSLFDINFWGPVEITKKAIEFFRSVNKPSGGRILNIASMAGYNAGPGMAIYSATKHALVGVSESIARELDPTWNIKITTIGPGGFRTKALDNVTSLPPHPEYTEPSLITNLIRQYLPVVPLPGDATKGAEAIYTISNVENPPANLILGADAREQVQERINNLTKELEAYEDLSASTAYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEZ6</accession>
    <name>I4YEZ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zf-ZPR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_44144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957208.1">
        <property type="nucleotide sequence ID" value="XM_006957146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEZ6"/>
    <dbReference type="FunCoup" id="I4YEZ6">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEZ6"/>
    <dbReference type="GeneID" id="18472321"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44144"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEZ6"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="272"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="476" mass="53133" checksum="DF08D8F0D985CED8" modified="2012-09-05" version="1">MSENLFKNVGDLVKDFEENPVQEMESLCMECEKTGTTRMLLTMIPYFKEVVVMSFRCEHCGNSNSEIQSASEIQERGSLHTVHVTSPADLDRQIVKSEHAVVSFLEYELSVPEGRGQLTTIEGIIRDTIRDLSMNQPLRKVLDVDVYNKINHLLSRLRGAVGASSDEVLPELVDGPTTTLEDKNRAEESHETLPFTAFTLQVRDPAGNSFVSFKESPNDPKWSYRAFNRTHEENVALRLANEDEKPQENVKQVAGFGDSDEITADEVFQFPGICSSCAKDSPTNMKKVNIPYFQDILIMSTNCEHCGFKDNEVKAGGAISEKGKRITLKVEDEEDLSRDILKSEHAGLNIPEINLVLEPGTLGGRFTTLEGLLQQVYEDLSTKAFIGDSAIATQAGDSGLVGNAQMQEFEKFLTQLKSVITAAQPFTVIIDDPLASSYVQNFNAPDPDEQIIIEEYERTHEQNDDLGLTEMKTENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF65</accession>
    <name>I4YF65_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_16328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957156.1">
        <property type="nucleotide sequence ID" value="XM_006957094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF65"/>
    <dbReference type="FunCoup" id="I4YF65">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF65"/>
    <dbReference type="GeneID" id="18470691"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16328"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_4_2_1"/>
    <dbReference type="InParanoid" id="I4YF65"/>
    <dbReference type="OMA" id="HIRAKSM"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="50"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="200" mass="21465" checksum="42C2A4BE1D4F7329" modified="2012-09-05" version="1">MSSSYSGPWYHAFGSGGLDGEDPLLTELGINFSHITTKSLAVLNPFSNKIDNRLMDDADLAGPLVFWGAFGLALLLSGKAQFGYIYGVALIGSLSIYSLLNVMSPQGIEVSRTASVLGYCLLPMVILSVISVPFQMDNWIGYGLSAFTTLWCTFSASGIFVTVQQMSEQRLLVAYPVGLLYACFALLSVFSEGGVVNKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF79</accession>
    <name>I4YF79_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_44262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957287.1">
        <property type="nucleotide sequence ID" value="XM_006957225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF79"/>
    <dbReference type="FunCoup" id="I4YF79">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF79"/>
    <dbReference type="GeneID" id="18472324"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44262"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009923_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF79"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="405"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="717" mass="79811" checksum="2B12DACF2B5244C6" modified="2012-09-05" version="1">MSTAKVYCVNGQPSSGASSLPQWISKRRLAAERTAGKSRKRSKAKVKERGLEESQLTLIQEFGFPEASNKVRTTPDGEFALATGTYKPQVRCYDLRELALKWERHTSSENVDFQILSNDWTKSVHLQNDRTVSVHSQSQLHYSIRVPKFGRSLAYHFPSCDTLIGGTGNQVYRLNLEQGRFLNPLDLDSTTVEGINAVDVNPAHQLWSFGVEGSGAGVKFWDPRSRNQIGSLDLPAEYLLEDNIANLGSGPLGVTALASHYNGLSLAVGTSTGHTLLYDLRASKPFASKDQGYGLPIKNLQWLESASGRYDQADGKVASADSKVIKIWDKESTENYVNLTPESDINDMHIVPKTGLIMLANEAPDMSSYYVPQLGPAPKWCRFLDNITEELEGDMTGGTGPSAWSDYKFVDKNELENLNLGHLVGTAALKPYMHGFFMSSELYSTAKMVSNPFAYAEHREKQIQDKLEKQAESRIRNATKPNVKINKNLADKVNKNATKKGKQDDQALLNDDRFKDMFENPDFEIDEESKEYALRNPAGVNKGKTAVEQEEEESDRDSMDEDMSKDSSSEDEDEQEEREESDDNIISAPRQTIAVPKQTKPKAKPTLVAGTVSEQTGNASDSFGDRLKGIEKKQQAKKAEDTSSIRRTGGGGMEMVFQPKTTEADDYKPQPKKQKGREQFGHGLEKGALVQDEGKDEQGRSRRRKNVRMASNNALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFB7</accession>
    <name>I4YFB7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_68102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957324.1">
        <property type="nucleotide sequence ID" value="XM_006957262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFB7"/>
    <dbReference type="GeneID" id="18475348"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68102"/>
    <dbReference type="eggNOG" id="ENOG502RZS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_6_0_1"/>
    <dbReference type="InParanoid" id="I4YFB7"/>
    <dbReference type="OMA" id="FPYACMY"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="431" mass="48619" checksum="21AA581AE1F8B47E" modified="2012-09-05" version="1">MTLPASLEFSKSVWSSTIRRVVFFSIWAAVIVLYGDKEIMSGVCKASKSLTMMVSIVIGLLVSMRASSSIQRWQDGRNLWSNIQSSTRSFLRLSSSIFDRNSDTAYDNTIEEFIGLILSFPVALKYHLRNKEFRGLEEHDLRVLLPRGYLASLKKSFPTRVHFEASPSPQPPSRSSSLASHREKDKEFKTPTVVRNVNFMDLDPLNDVRRRPSYETSELEKQHEQLNIKESDENLSVPRSVLSNSRPSNIPLSVLRLLQVYLNGFYNNRPERRNDNMKTHIDTPLFVNMIGYLKELTDLMTQAEKIRDTPIPLILSIHLNQVLALYLLAIPPQLVSSLGWMSIPITGLVTFFFCGIDAISSELSEPFGSDLNDLPIDKYCLDIIKEAQDIGGYASSVSRNALGDGLANKPSSSFKPTPVRGSDWKPSCFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE7</accession>
    <name>I4YFE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957353.1">
        <property type="nucleotide sequence ID" value="XM_006957291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE7"/>
    <dbReference type="FunCoup" id="I4YFE7">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFE7"/>
    <dbReference type="GeneID" id="18471381"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31877"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_2_2_1"/>
    <dbReference type="InParanoid" id="I4YFE7"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="23558" checksum="3CC815081AD9AA37" modified="2012-09-05" version="1">MSSMNIDQPLEDVIKAKRQQQRSNRKQTQQRKRTAGPKQGGSKRLAQGAKPVAGRVVPKTKQGAPINEQTAKKIIVSNLPLDVNDQSLRELMTTTIGPVSECSISYDQKGNSKGFAQVRFKRPGDGNKAYNDFNGRLIDNNRPIKIEIVVETADKSSLVNRLAPKVNEKPAPKKKALKKPAKKRGPKPEKRTPKTAEDLDAEMEDYTQSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFI4</accession>
    <name>I4YFI4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_36795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957387.1">
        <property type="nucleotide sequence ID" value="XM_006957325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFI4"/>
    <dbReference type="FunCoup" id="I4YFI4">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFI4"/>
    <dbReference type="GeneID" id="18471980"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36795"/>
    <dbReference type="eggNOG" id="KOG3869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025093_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFI4"/>
    <dbReference type="OMA" id="SWHPHTM"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="47902" checksum="4D000B270FC106B0" modified="2012-09-05" version="1">MGGGDLNMKKSWHPMLMKNQRVVWDKEQEVIQENKKLDQLRREKQEERQLQELQKLQEASSGKKASDRMEWMYAAPATGSGLSANDMEDYLLGKKRVDNILKGNDEVNLANTQQDVIQTQKANTSRDTSSKIREDPLLSIRQQEQAAYEALINNPIRLREMRLKAGIPDTDSKSEKRAAKEERKRQREEKRRLKDDRDDRRPERHDRPGDDHYDRKRYDDRYSRRDSDRYDDRYSRRDDDRYSRRDDDRYSRRDDDRYTRRDVDRDSRRDVNRDSRRHSRRSPDYRDYEREKNRRSISPPRQNRPSPPRHERSHRPSPPQLDDQEARAAKLAAMSSSARDLQAERDVRLSEMAKRDAEENARDAILRSRDAKYGGHNKFIADEQRKVYSGEGGLAEQMRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ7</accession>
    <name>I4YFJ7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31908</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957398.1">
        <property type="nucleotide sequence ID" value="XM_006957336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ7"/>
    <dbReference type="FunCoup" id="I4YFJ7">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFJ7"/>
    <dbReference type="GeneID" id="18471389"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31908"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFJ7"/>
    <dbReference type="OMA" id="HINTPSI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="151"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="333" mass="34839" checksum="54CAC453FDF13D41" modified="2012-09-05" version="1">MSLIKAAICGAGGGIGQPLSLLTAQNPHIGEVALFDVAPSVYGVAADLSHLDGTAVVNGYTKDNDGLKQALTGAKIVIIPAGVPRKPGMTRDDLFKINASICRDLATGIADYAPDAIIGVVSNPVNSTVPVFVETLKSKGVFDPKKVFGVTTLDIVRASKFVAEVVGKPNQAPQYKIPVVGGHSGKTIIPLISQSKPAVDIQGETLDKLINRIQFGGDEVVKAKDGAGSATLSMAYAGAKFLNAVLDAVYGGKPSVIQSYVYLPELQGGDSIKNEIGKELAYFSVSVQLGKQGIEKVLPLGQLNDYEKRLLQDALPELDQSIVKGVGFGKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFK4</accession>
    <name>I4YFK4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957404.1">
        <property type="nucleotide sequence ID" value="XM_006957342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFK4"/>
    <dbReference type="FunCoup" id="I4YFK4">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFK4"/>
    <dbReference type="GeneID" id="18474836"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63376"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFK4"/>
    <dbReference type="OMA" id="WGGKIAC"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="249" mass="27708" checksum="5C62547CD5938C5E" modified="2012-09-05" version="1">MSSACCSIPPVIDQTNYKPKGTYEKVGHFEKAYVTGPSDAHTVLLGIYDIFGYFNQTLQGADILADKGYRVVLPDFFRGKPFPLEKFPPSNDKDKKELGDFFATIASPSARIPELLNLSNELRQKHSKLGLVGYCWGAAIALNASTQDIKLFDAVAVLHPAMLDAGVVEKVKTPIGFFPSKDEDGAEVDKVIKILSSNEFKEKNAYQHFKSEKSIHGFAAARSNLKDEEAKEIYKEAYERLTDFFKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS6</accession>
    <name>I4YFS6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_50388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956871.1">
        <property type="nucleotide sequence ID" value="XM_006956809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS6"/>
    <dbReference type="FunCoup" id="I4YFS6">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFS6"/>
    <dbReference type="GeneID" id="18472523"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50388"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFS6"/>
    <dbReference type="OMA" id="YSAHDHE"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="10725" checksum="869585C40B219BFD" modified="2012-09-05" version="1">MSQELATTYASLILADENLPIEAENILKLTSAAGVEVEGIWATLLAKALEGKDVAEILTNISSGAAAAPAAAGAPAAAADAPAEEAPKKEEAKEESDDDMGLGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX0</accession>
    <name>I4YFX0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_67752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956911.1">
        <property type="nucleotide sequence ID" value="XM_006956849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX0"/>
    <dbReference type="STRING" id="671144.I4YFX0"/>
    <dbReference type="GeneID" id="18475290"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67752"/>
    <dbReference type="eggNOG" id="ENOG502S7SS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1564111_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFX0"/>
    <dbReference type="OMA" id="TIEYIHA"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="171" mass="19539" checksum="B8E06E8FC0680D71" modified="2012-09-05" version="1">MAEFDVNSETSANNRENNSTNKRNTNNLTAEEKKLNHIRSEKKRRNMIRLGYEELTKVVPDLQDRVERKSKRRPGRIPLQAQQKEKESAEPEFAPGGPISELVILNSTVDYLRKLTSMRDELISRLHQLQTSHPLPSLVAPPSAESIVNSTVELEQPIWLSKWTGQGDIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX6</accession>
    <name>I4YFX6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_36092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956917.1">
        <property type="nucleotide sequence ID" value="XM_006956855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX6"/>
    <dbReference type="STRING" id="671144.I4YFX6"/>
    <dbReference type="GeneID" id="18471943"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36092"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="I4YFX6"/>
    <dbReference type="OMA" id="KKDFAFQ"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="38375" checksum="F44AF5011CBE4964" modified="2012-09-05" version="1">MKAIVSEKASEGLKLVSRDIEPLRASEVQLKVITCGICLGDEVGMHHGAFYPLTPGHEIVGEIKAIGEGVHAIQSAMDDGNPWKFKAGQRVGLGWFSGYCKECYNCRRGYLTGCKLANATGLTRHGGWSEYVNADYTALVPWPKDIDPNQAPMMCAGLTVFNAIRNSSKCKPGNNVGIIGMGGLGTIAIPLVKAFGMNPIVISGSKQKESKAEELGASAFISRQDPNFVNQIKEHTDSPYGYGYGPGGVDLLLTTSPDVDTASKIIEGGLAMEAEVIMLSEPADLQFKVPVIPLLMKRATIKGWSAGCPRDVEDLLVFCRQHSIWNVVEEVKLEDVTRKFQEIGKGIGRFVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ5</accession>
    <name>I4YFZ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956936.1">
        <property type="nucleotide sequence ID" value="XM_006956874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ5"/>
    <dbReference type="FunCoup" id="I4YFZ5">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="GeneID" id="18473487"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59668"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="InParanoid" id="I4YFZ5"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="471"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="647" mass="71430" checksum="B1E8EE91A02F984F" modified="2012-09-05" version="1">MVTVWLANIKTGRCVDKIWQTSKIMCDSWTKWTDWKLLNYSIYVLLSVIFAFIAALAVKKLSSRAAGSGISEIKCIIAGFENKEYLRWPVLLVKTCTLPFAIASGLSIGKEGPSVHVACCVGELVASLFPYFHKSKLKMREILIAASAAGVACAFGSPIGGVIFSIEEMTHTYTTKMIWRSFFCALAATAMLSALNPFQTSGKLVLFQVTYDKNWHFFEIIYFILLGIFGGLFGSLVIKLNMLYVGFRRRHLSENGISEAVILALITSVICYPNPFLRTDMTESMSILFRECGGREEEDFGVCDNDRNWSTINSTLLATIVRTVLLIITYGAQVPAGIFVPSLAIGATFGRLVGTISKMLYQANPSLGIFSECNNDMNCITPGTYALLGSAATLSGVMRIWVTVPIIIFELTGALTYILPTMIVLITTKAISDFLSGGEAGIADQMIKFNQMPVLTREDEHYFNVDISSVMTRDVVVIEEEMLVRDVDSVLLNAHSRYPIVNNREDMKLVGYVDAGILSQSLASIPGLSQQAVLKFSNKRTIFDADAEPDQAEYNLNDTVNDIPMTISPTTSLDVVMKLFKKIGPSVILIAKQGVVEGIVTVKDVLRETEMIKVGNERAISATKASITEDLIDFWNKFKQRLINVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG89</accession>
    <name>I4YG89_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957022.1">
        <property type="nucleotide sequence ID" value="XM_006956960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG89"/>
    <dbReference type="STRING" id="671144.I4YG89"/>
    <dbReference type="GeneID" id="18473511"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59711"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="I4YG89"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="19">
        <location>
            <begin position="15"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM22981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="570" mass="64522" checksum="9B3CD82C5CE536CE" modified="2012-09-05" version="1">MSKNLYAQQSKLPRLPVPALEETLEKYLESAKPFLSTDEFKNSKQLLDSFKDGQGKLLQQRLLKRASEKESWLIDWWNSQGYLEPRDPVTPYSNYYFYHRQLIGNNQPRVAASLIKATLAFKQLVDTEELEPENIKGTPLCTHTYQYLFNSTRVPLRDSDKVVKFDQSNKHVIVISNNRFFKLDASNPNNLESQLQHIIDISSDKKGDAIGSLTTENRDIWSDARHHIQSISKTNSESLKAIDSASIIVALDESAPISRDQASWGAWVGDGRNRWFDKHQIIVYKNGKSAFNAEHSAMDGMITLRLNEFIMGALASKKISLGESTPVKQLEVEELKFELDNKAREYIANAEKHHDAIMGAHTMDVIQYDGYGSNLIKSKKISPDAWVQMVKQLAFWKLRGRAPGVYESCQTRKFLYGRTEVIRPTSNESTEFVRLMRDFNASDDARINALHAAAKRHLTYAGWAANGVAVDRHIYGLKNCLKEGEELHPALKDAALARSNKWELSTSQLSSPFFDGWGYSEVAADGFGLAYSIQDKSIRWTITCTNGEGKDLGHCLTESANELRELMEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGI4</accession>
    <name>I4YGI4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_31702</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957109.1">
        <property type="nucleotide sequence ID" value="XM_006957047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGI4"/>
    <dbReference type="FunCoup" id="I4YGI4">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGI4"/>
    <dbReference type="GeneID" id="18471357"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31702"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023471_4_0_1"/>
    <dbReference type="InParanoid" id="I4YGI4"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="486" mass="55712" checksum="00828FB520EB8FDB" modified="2012-09-05" version="1">MTMKYSNFNLLQVEDTEDSEDVQSKHIKPQNKSQKKKKSENKPAKQEVKAVDSNITKEHHSDSQPVQQPQQPQQPQQPQQKTPPPSNDHTGGSKAKKQAIVTRTIWTFIMVFGFFGCLMAGHAWLIMLVMLCQSLSYREVTALFGFKTEYGLKAENSERDRWSTILNWYFFIVTNYFLYGESIIYYLKHIIFADVYFIQLAKHHRFISFMLYVIGFMGFVANLKRTFLKRQFVLFCWVHMSLLLIVLSSHFIVNNILEGIIWFWVPASLVICNDIFAYVFGMAFGRTPLIALSPKKTVEGFVGGGIATVLFAWGWGTLFQQWKYMICPVHDLGTSIFSNVDCVPNPVFIWRDFEIPSVISGLLSSLAQQEITKIPYTPFQIHCLFMATFASVVAPFGGFFASGFKRAFDIKDFGDSIPGHGGLTDRMDCQFLMGLFAYVYYSSLIREAHVSSGQVLQTIVSSLRPDEQIELFRDFKKYLESQNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGL0</accession>
    <name>I4YGL0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957135.1">
        <property type="nucleotide sequence ID" value="XM_006957073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGL0"/>
    <dbReference type="FunCoup" id="I4YGL0">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGL0"/>
    <dbReference type="GeneID" id="18473554"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59781"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGL0"/>
    <dbReference type="OMA" id="QIYWHES"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="322"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="556" mass="61772" checksum="C242135C52881653" modified="2012-09-05" version="1">MDIQPYSSNALKKVLNSAEISQHQTYRLATGGADHQVRLWLIHPQQNIRDSNANTILQNPHQPRAEYLCTLSRHTNPVNVVRFCPKGETLASAGDDGNVLLWIPSDQKTASYGESSSEDLQFEKEFWRVRIMARCARDAEVYDLAWSPTGEYFVAGSTDNTARIFSAIDGVCLHQITEHNHYVQGVSWDPFGSLIATQSSDRSLNVHSVKNYEKGGLSVHSISKFSKSDVHAHTPKQLTHKRSSSSTMNNNGRRRLSVASATSENDHSQSLSQEPGLQTPMQPPSRRSSLSQQQSQSNIPSSAASSPLTPVKRSPSPLPAIKTPSNKLNERISYGDEGFTQFFRRLSFSPDGSILVTPSAQSDDIPSEDGKKKSIAKSSVLIYGRSNLNNPLAVLPGHKSATVGVRFNPILFNLRQRSEKPAFDLPYRMIYAVVSKESIIIYDTQQLSPISILSNLHWAAFTDVTWSPDGQSLMLASLDGYCSIIVFDPEELGTPYKEQQHQLQMSAIAENVQVTPSQSHTNTHVDIQAEKQVENQTVVNQLPVKKKRRVELTRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM3</accession>
    <name>I4YGM3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_50428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957148.1">
        <property type="nucleotide sequence ID" value="XM_006957086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM3"/>
    <dbReference type="STRING" id="671144.I4YGM3"/>
    <dbReference type="GeneID" id="18472525"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50428"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="InParanoid" id="I4YGM3"/>
    <dbReference type="OMA" id="IWHSYER"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="124"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="516" mass="57711" checksum="D37392DF27E10606" modified="2012-09-05" version="1">MVQELSRNIPEWQIADLSLHAYSRISVPLYDTLGNDSVEYVINHSEIKLVFTTSSHLPGLYRILQKCPTVKAVIVLDGLDEPGAPKFDARIPGQLNRADVLKRWADNLNVQVYDLVENHVGWLLASYLPLAHILQRSLEFIAIVLMSPIAYTTGDITLLMEDLQIMQPEMMVTVPRVLNRIYAVIKHQMDLPGLKGSLLKRGIATKLDKLRKTADPTHIFWDKLVFNKIRQVIGGKIKLIITGSAPISPEVLDTLKISLCIPIVEGYGLTEASICVRTLKDDPSASGSVGPVVPGFEIKLMDVPEMNYYSSDQPSPRGEICIKSESSMKEYYKDEEKTRESFTEDGFFLTGDIGSFDDKGRLKIIDRKKNIVKLAQGEYIAIEKLEGAFALCPTILQIYVHADSLRSYLVAIVVPDPLELAKIAHCDPSDRVSLDNAIKDKKINDMILSEIEAASNKAGLKGFERIKAIHLVNDQFTIDNGLLTPTLKVKRNVVRDFYKSTIDNIYDMTDKAATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGV7</accession>
    <name>I4YGV7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_53542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956593.1">
        <property type="nucleotide sequence ID" value="XM_006956531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGV7"/>
    <dbReference type="STRING" id="671144.I4YGV7"/>
    <dbReference type="GeneID" id="18472618"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53542"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_7_2_1"/>
    <dbReference type="InParanoid" id="I4YGV7"/>
    <dbReference type="OMA" id="RIAFKSH"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="21034" checksum="DCDCE23140290EFB" modified="2012-09-05" version="1">MKTVEDFCRVWNWCKPPSKLERHSNYHFFKDGIKPLWEDPANSHGGKWVIIVRNSHWLLDRCWSWLVMGLVGEEIDDDDLITGAVVSTRPRGDRIQVWTRQTKVEECNEIARKLIKILEIGNDNNNNNISLEFQYNQSNPPSTNGFIHIVPSYNNNSPSTTPTIASNGGFKIPNTPTDRWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH10</accession>
    <name>I4YH10_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_35686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956643.1">
        <property type="nucleotide sequence ID" value="XM_006956581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH10"/>
    <dbReference type="GeneID" id="18471924"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35686"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028895_4_1_1"/>
    <dbReference type="InParanoid" id="I4YH10"/>
    <dbReference type="OMA" id="TIRERSW"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="361" mass="40407" checksum="D840F2D2B795EE76" modified="2012-09-05" version="1">MDNHKLFVGSTYDGLLILEASRLGLLPRVTRRLKEAERDLVQSGSVFVFDEHESGMKRWTDGLYWSPSRILGNFLIYRETNKTKRNSQSTSAQQHSSTSYSVDTFDPINQNSSDDEHGSEKAKERSLVGSLTKSDMFKDSGLVKKTMSLSFNGSAQHLISYYRVEDVQKGRLRAPSTLPEFQSLSISQEYLIKSNFRCPIRTEVDPDGLLRYRGEHEDLSQYSPPSIQAALPNYQQHQKSRSRNNSYSSYSRAGSRSPPYTSTSPAVAINNGVGKSSPTSIGSHRYTPYGSPTSRTITNLPMSMHAVSPIVSSSQPVHRHPGMLQAPFDYYNSYAGVQAPVPTQPPPQYFPNQFNNNNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH49</accession>
    <name>I4YH49_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_35753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956679.1">
        <property type="nucleotide sequence ID" value="XM_006956617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH49"/>
    <dbReference type="STRING" id="671144.I4YH49"/>
    <dbReference type="GeneID" id="18471929"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35753"/>
    <dbReference type="eggNOG" id="ENOG502QTJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH49"/>
    <dbReference type="OMA" id="VWAFWSS"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="333" mass="36533" checksum="897243ACE9F1A3AF" modified="2012-09-05" version="1">MSFSQTRQFGSWQYLCQESPSLAPCNLFFKQILSLGDRGEDILFSNPAFSLLDDRLDGAGVGVRPHCFITRASVQGGLGNIAQIVCTALCLVFSLILFAAAKRRVAAVARIEFATLIGLWSLIDVLSLLTTGGFLQQGTDYLVWITAIQMGFRSAWFWALLVNGFNSTQLLEDGTPASIGTLWTGGIAFFVGTAYIAVDTAFNWSGRLPPSSPPEYLISNGLFVLLLLWPMIATFLFTALMIYVIFFLLKETLPAFWYASSLLTFMLSQAALFALGYTICDGSNSRVDGAFVATLLEAISLGFLFGGWRSITEDSWYAYEGAQEPVYPKHAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH64</accession>
    <name>I4YH64_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956693.1">
        <property type="nucleotide sequence ID" value="XM_006956631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH64"/>
    <dbReference type="FunCoup" id="I4YH64">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="GeneID" id="18473421"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59552"/>
    <dbReference type="eggNOG" id="KOG3472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096548_0_2_1"/>
    <dbReference type="InParanoid" id="I4YH64"/>
    <dbReference type="OMA" id="VEYQFYH"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="120" mass="12445" checksum="23ACF5D818D3E3D6" modified="2012-09-05" version="1">MNSTVVWKSGALLAATGISFGAFGAHGLRSRSGIEAKQIESWMTASHYAVFNGLALMATSLHPRASKSKFAGPAILAGSLLFSGSIFALVLNKEKFKFLGPVTPLGGLSIIAGYLTLACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHH5</accession>
    <name>I4YHH5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_15511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956509.1">
        <property type="nucleotide sequence ID" value="XM_006956447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHH5"/>
    <dbReference type="FunCoup" id="I4YHH5">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHH5"/>
    <dbReference type="GeneID" id="18470664"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15511"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_1_2_1"/>
    <dbReference type="InParanoid" id="I4YHH5"/>
    <dbReference type="OMA" id="TRNNCII"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="400" mass="45493" checksum="31A7090833D1E5EE" modified="2012-09-05" version="1">MSRFRWRWRSADNEDVSVKNAPLWPQSYERTSSTLLERGMWGRTNNEIYLRCTVIDAKGNVKTVSGKFRKSDLCAEHSLNPRDLRKVDSRIPNIVPTILARKEAFLINILHVRALVKSDAVLLFDPIGSVDTRLQSVFLYNLEHNLRDVRSAMPYEFRALESILLSISAALESEMDITTRLVSDLLLDLEDDIEREKLKNLLHYSRKLSGLRNRATLVHEAIEEVLKNDEDLASMYLTDKKAGQPRQEHDHDELEMLLESASKQIEEIVTEADALDANVTSTQEIVELILDSNRNALLALDLKVSIATLGIGAGTLFAGLFGMNLQSHLEENPYAFYSVSAFTAILSAGVTFACLRRLARIRRIKLGMKSPDSNYMKKHINIDRGSIWKRLYSHGWPILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS2</accession>
    <name>I4YHS2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase 2</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NCA-2_31041</name>
        <name evidence="20" type="ORF">WALSEDRAFT_31041</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956191.1">
        <property type="nucleotide sequence ID" value="XM_006956129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS2"/>
    <dbReference type="FunCoup" id="I4YHS2">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHS2"/>
    <dbReference type="GeneID" id="18471236"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31041"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_0_1"/>
    <dbReference type="InParanoid" id="I4YHS2"/>
    <dbReference type="OMA" id="MINVHDI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="566"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="871"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="916" mass="100062" checksum="52F42D1CC75E1578" modified="2012-09-05" version="1">MVIVAVGLQSYNGRILASLNEEEDEGTPLQTKLNDLAELIAKIASVAGLLLFIALMIKFFVNLKRQPDRTPREKGQNFIEVLIIAVTLIVVAVPEGLPLAVTLALAFATKRMTKANLLVRLLASCETMANATAVCTDKTGTLTQNVMSVVAGTIGIKAKFVTRLDENSSRSNADELNNDEKYPHGNFTIDSNDLSNHVQGPLRKLLFDSIAINSTAFEDKNKETDQIEFVGSKTETALLRFAKEQDWDDWRSVRESAEIVQMIPFSSTRKAMGVVVKVNEGHYRLFVKGASEVLTSLTNQVVSLDEAKSDEVPCHAIEEGERASIDETIKFYANQSLRTIALCYKDFQEWPPSKASFDETGDVEYDSLAKDLTLIGITAIEDPLRPGVSNAVKRAQNAGVKVKMCTGDNVLTAQSIAKQCGILTEGGIVMEGTEFRQLDEHDRINVVQNLQVLARSSPDDKKLLVQTLRNAHSETVGVTGDGTNDAPALKAANVGFSMGIAGTEVAKEASSIILMDDNFASIVSAIMWGRCVNDSVKKFLQFQLSVNVTAIIIVFVTAIASDSEESVLSAVQLLWVNLIMDTFAALALATDPATPTVLDRKPETPGSPIINANMLKVITSQSLYKTAVVFVLHFAGRQILGYRMDYSNDEEEAEYSAQGSQLKTLVFNAFVWCQIFNQINCRRLDNKLNVFEGIHRNWWFMIMFCIMVGGQVLIVFVGGAAFSVTRIGGRDWAISIICGFCSLIVGALFRFIPDEPIERRLIKWGAFPDPNALPISKNKPSRKGEDPVYDSLQILSILRGGRIRGSSFVQKSRRIVRHPIQQLSETLYSHSRSNSGTTTPDNNSTSPLSAKHNHLDALSVLPMMVASSVGAGPAYRSSRSGSVNSRAGHSPSTSISKGGIDDDNSSQPPPSPLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHV5</accession>
    <name>I4YHV5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956224.1">
        <property type="nucleotide sequence ID" value="XM_006956162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHV5"/>
    <dbReference type="GeneID" id="18473254"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59258"/>
    <dbReference type="HOGENOM" id="CLU_1020152_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHV5"/>
    <dbReference type="OrthoDB" id="10426765at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="30986" checksum="8B0F60532B742D17" modified="2012-09-05" version="1">MSPSQKSTDVQCGELDRLRNGVLGLDDLKSLSKRSKHSYGQIPVKDLRKFKNNKGLIKDTEEFLVLYKFHGPPSDDFEVFSLDDFNKVPYVRGKDIPADQCALAYLPIKVILPAGVTPTREIITFFQENEYIQLLQAHLAYHCILYFETTKVGWCRAGDWFCNICKMMSWAKRTYCHHTNLHKDDTPMVFVKKDIAICMPEVETGLAMGNRVFALSGSYLGMEARQGPRTRNKVNAIRAMVAALVVALIVALQPLQLLSALQKLHSRNHRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI93</accession>
    <name>I4YI93_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_35292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956351.1">
        <property type="nucleotide sequence ID" value="XM_006956289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI93"/>
    <dbReference type="STRING" id="671144.I4YI93"/>
    <dbReference type="GeneID" id="18471910"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35292"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007805_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI93"/>
    <dbReference type="OMA" id="NGRRINP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000465">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="284"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="566"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="855"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="896" mass="101770" checksum="73CFC063B1205EF6" modified="2012-09-05" version="1">MLEEHWSIKVIEPPSKRNKVVYTLYCKTPTQSLTLIRSASTIRNLDEALHDKLPDAQIPVLPVSLHSNSRRRSFLTTITKFASNPSTPSKPKHSIQPPMSPPPNVSSAPANELLSNYLTELANDERVRAQVAWKRFTRVRPDDLQSNRIDRRRSQRLNSTSALSNNIIPSIKEEQSETALPGINKNADSKDFASILSQLDKALDNSTFDKNLDTTQKEEFINETDKPVTSDEIVKSASFNDSLVKSHELFQSEPNLQSIRSENKEKTTRKVIRKKQAKVKIQDFEMMRVLGKGCAGKVLLVKHKSNGGYFAMKAIHKRHVLAHQELLHTLTEQTVLKRMTRDVLNPFIVQLHYSFHDESDLFLAMDFHPGGDLATQLSRWGRLGRDRARFYAAEIVEGVEGLHAAGVIYRDLKPENILIASDGHIVLTDFGLSKQFPRPEGPIKVLPEWMTTTASSTPNIDPKDATSSFCGTAEYLAPEVIQGLPYSYEVDWWSLGTMLYEMLAGITPFWASNHSDMYVRVLHDDLDFGDERYMDQDTKSLLRGLLQKNPALRLCEPRIKRHPYFGMLDWGHIAAKRYIPPYIPPTNPNDDLDTQNFDETFLDMEPVIDDDDLNASNIDPERAAVADQAIRDADANNQDLFDKYSYRRLNEDGNSIMYEEHEEVDNEETNDDMIEKLDGVVEENLTEQLQTEPEQQTEPKRESEPKPESQPPLTEKPTETARPTSPPLSLPEKSDIRQETNGIKKRRREKSGVMAFDKPFMSSASSIADEEDVTDDNDNDEEDEWDMVDLDTPMAPNGHRINPSTLFAKGVTDKYKLILRRQNSTINNTVEHQADNSESKKSVGLSLSNTLNLKKKRGFLSKSRPNSPNKGSSSDGEYQNDENKRDLKDLFNLFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIH8</accession>
    <name>I4YIH8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956433.1">
        <property type="nucleotide sequence ID" value="XM_006956371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIH8"/>
    <dbReference type="FunCoup" id="I4YIH8">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="GeneID" id="18473333"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59401"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="I4YIH8"/>
    <dbReference type="OMA" id="ELIMIMT"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="87"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="529" mass="59040" checksum="EF27927E413F277C" modified="2012-09-05" version="1">MSTASTLNEPNTTHPVSQGDEKSLWGNARQDVNTLKEAEHLGKGYYTNVSPNELNRELEKAEEDKFLVELDDGDDPKKLSTAYKWYITLLAGMQILNATYSSSVVSSAFSLIGEEYNQVQEVVVLTVSLFLAGYVFGPLLWAVIGELVGRKLTYISYLVLFIVFNIPCALAPNVTCLIICRFICGCAAAASMVTSGGVLADIWEPIRRGRPMALYSMCPFAGPVLGPIASGFIVDYASDYKWIYWSQMVFGGCCLIGVIFSFPETMTQVILIKKAKKLRKETGDKRYHTFSELNAPPFKQQLKIAWQRPFRMLVREPILIITSLYIGVVYGVLYLSFEMFPYVFRGDYQFTVWQSGLTFCSVAIGLLISYVVNLLFDKRYLRIAKKSIRETGQRPDPEIRFLPAIFIGGPCFAIGLFWFAWTAGRTHWLAPCAAGVVLGAGVVLIFISLLSYVSDAYTLYASSALAANTVVRSIFGAVFPLFALQMFDRLTISWSGTLLALIGCALMPFPVLFHRFGKKIRNKSDYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YII6</accession>
    <name>I4YII6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956441.1">
        <property type="nucleotide sequence ID" value="XM_006956379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YII6"/>
    <dbReference type="GeneID" id="18474751"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62447"/>
    <dbReference type="eggNOG" id="ENOG502SG0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1526360_0_0_1"/>
    <dbReference type="InParanoid" id="I4YII6"/>
    <dbReference type="OrthoDB" id="4932133at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045992">
        <property type="entry name" value="DUF5948"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19373">
        <property type="entry name" value="DUF5948"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697830" description="Hydrophobin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="19580" checksum="EF4E721E83600459" modified="2012-09-05" version="1">MFKTTVISALLASATLVSAGGPAEICTSKGGTSCTEYQITKDCCAAVDQNTRFDEVFTQCIPLLANGINTGGMVECCESRGAGSAEVKIGADKLFKTTVISALLASATLVSAGGPAEICTSKGGTSCTEYQITKDCCAAVDQNTRFDEVFTQCIPLLANGINTGGMVECCESRGAGSAEVKIGADKLVCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP9</accession>
    <name>I4YIP9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955687.1">
        <property type="nucleotide sequence ID" value="XM_006955625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP9"/>
    <dbReference type="STRING" id="671144.I4YIP9"/>
    <dbReference type="GeneID" id="18473096"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58966"/>
    <dbReference type="eggNOG" id="ENOG502SDDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088029_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIP9"/>
    <dbReference type="OMA" id="VIHMHES"/>
    <dbReference type="OrthoDB" id="3266199at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="25076" checksum="CD8783CEF36E3B25" modified="2012-09-05" version="1">MQESSTDLKPFLLITVGRSHSFDNLQQIKSTINLAIKYDSDKVLNILRGDLFFHAYKEPLRAYALAAKLGWEDDAIKLSTLTLESDIENLPDVDADSMPTHYYRRLAKLHQTRQMEARRILTSQDLIMSNKHEGDYDRVAHVEWWNSIQQAMLTRLDGSHGSKSFKFPSTLPYLDCVKNKAYIDGDKDVLSFRGLYLIYRTMEVVETAWKDKLPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ40</accession>
    <name>I4YJ40_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955817.1">
        <property type="nucleotide sequence ID" value="XM_006955755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ40"/>
    <dbReference type="GeneID" id="18473142"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59041"/>
    <dbReference type="HOGENOM" id="CLU_912776_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ40"/>
    <dbReference type="OMA" id="HRMESNQ"/>
    <dbReference type="OrthoDB" id="10499628at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="305" mass="34283" checksum="849AC5DE3544F535" modified="2012-09-05" version="1">MAEEYEDGPDPFMVDLGEGSQGNLLEESHRMESVNQMQSGNSLAFELAAAFGGSSTQDIPEQEEKPAESSDIATVNVVEDNDLSDSSDESRDVIDSDKLDEYNKELNNGIEMNAGFLKKLKDIDSGLPLLESTATVIVKRLVETAKIRDDQSRQLWELDKELSKEDDWTLSNLDALDDDENHQLDIIPEDEEDSAEKTEKSEKSSIPSLEGLVDDYIQESLTSITEISQISTASLNESSRKTRSMKTMLISIKGEEERTERAKDIIQRLENKSKLSIKQLSENILSDFTIQLNKLNEWVNVQRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJG2</accession>
    <name>I4YJG2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_59093</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955930.1">
        <property type="nucleotide sequence ID" value="XM_006955868.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJG2"/>
    <dbReference type="GeneID" id="18473170"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59093"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_8_1_1"/>
    <dbReference type="InParanoid" id="I4YJG2"/>
    <dbReference type="OMA" id="YSIMAVH"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902850">
        <property type="term" value="P:microtubule cytoskeleton organization involved in mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000996">
        <property type="entry name" value="Cytoplasmic dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="16">
        <location>
            <begin position="238"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="17">
        <location>
            <begin position="1314"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1859"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1590"/>
            <end position="1617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1979" mass="228811" checksum="88DE76912F9D9033" modified="2012-09-05" version="1">MSVADALQINPEPPPATEPIDEGLDAHSFKLYLQDLLPKLLNADTSDLITLWNENTEEDILRFANDQSLMGLYIQQLRTDDDPPRFTYNLTHTLTHPPNLVSTVFMLKRFPTLSPVDPLSSQLVILNLADGGYEVLHALVHLAAAPYFDAFVNAKGKGGDINKSKDSDAKLGIPMTKKKFAELELSLLHLQQNVEIPETHLVIHSAVRDAVTMAHNAGTRPAPSDVQPQSLLNDSTFLNRLQNDVNSWIKEIRNVTKLNRDVASGTASQEINFWLSMERALESIEEQLKSEPIMLTLEILKYAKRFHATVSFIADTGLKEATDVVHKYNQLMKDFPLDELLSATDFDKVQDSLYLIFGHINKKLKLSPYPIRRALPLVEAISKDFNDQMLRILQSHRLMYMEYESFERSINAADSAFRVWDDVLKEFTNVAREVTRKRSEKFLPIKINAAHWKLAERCNYLRNFRKQHEQLRTMTAMKNTKAGSGVVADNLTDLDMEDEVKAAYDTLKNVNVLDISVEGTEIWIAAETAYNERVARVENQIIARLRDRLGTARNASEMFRVFGYYNALFVRPKIRGAISEYQTQLIDSVKEDIKRLHGKFTMQYKNTEAFHMSQLRDIPPIAGAIIWAKQIERQLNMYMKRVEDVLGEGWDLYAEGAKLQSESTSFRKKLDTKPIFDAWLHEINRRDMRIEGRLFEINRTRNSLTGELNVYQLGVNFDPQVITLFKEVRNLIWRQFQVPHAIVNIAKDAKRVYPHAVSLMETVRTYSLTVERILANPGIETLIAEYRIEAQNIITRGMPLRWEFFVNTYDTRFGALSSIEGREGRHMYFIREFASSVSILQDKTDDLIDTYNDVMRIIDELSTCPFNNEIFTSHLTTIQKTIDKLNLEGYANLDSWVAALDSKIENVLLERVKQIIDEWCIAFNRSKEEAPVSRSKEAIRKKVKHEHEHFVELEQLYHEIRIRDQVIYVDPPIEHSRTEWYKQLHVWLGVICNLPRIQSSRYEIGLQFDKVSESSHDNTYTTLLTKLPFETLSKPFALIEDKVKDVGEYVGKWLQFQSLWDLEGEQVYSRLGDSLALWQQLLSEIKRTRSTFDTSDTQHTFGAAIVDFAQVQVKVNAKYDFWQRDIVTRFGQKLKDAMKDTHSAIQKARYELETQSIEGSSTVQAVSFITFVQDIKKKAKKWDPEIAIFVESEKTLDKQRYQFPSDWMWVDQVQGEWSAFNEILKRKNDLILEQLSGLQLKIDAEDKIVRNKIEEITKEWEDNKPIQGNIRADQAMNTINIYGSRVEQLKSQYDLVFRAKEALDLEHMNDDRLEPVLEELKDLRAVWTALSGVWDQIAEIKETTWASLQPRKLRSSLEGLLNSTNEMPSRMRQYSAFEFVQDTLRSYLKLNSTISDLRSEALHDRHWNQLFKSLKINRVYSPNNMTLENIYDIDLKRNESLIRDVITQAAGEMALEEFLKQVRETWSSYQLELVNYQNKCYLIRGWDDLFSKCTEHTNSLTAMSNSPYFKVFEDDARSWEDKLNRVHNLFNLWIDVQRQWVYLEGIFSSSADIKHLLPMESQKFQTINTEFYNILKGVKRSPYVLEVLGITDVQKRMEKLAETLNKVQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKDILRIMKHLKKMFAGISNVILDEDITEIQAMVSKEGEVVKFSNAIQLKDYPKINDWLAKIESEMRTSLADLLTEAVESLREFYSNEDKLDVDIFLNWMNRFPAQLVVLAIQVEYSTIVDKDLQSGSDLKSPQTIILRTLDVLADTVLTNLPTIQRRKCEHLITELVHQRDVLRSLIRDEVKSHRDFNWLYQMRFYLDTSVSNSIDRLNVHMADATFDYGYEYLGVPDRLVQTPLTDRCYLTLTQALNSQLGGAPFGPAGTGKTESVKALGVQLGRFVLVFCCDETFDFQAMGRIFIGLCQVGAWGCFDEFNRLDEGTLSAVSEQILQVQQALATSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK3</accession>
    <name>I4YJK3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_26847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955970.1">
        <property type="nucleotide sequence ID" value="XM_006955908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK3"/>
    <dbReference type="STRING" id="671144.I4YJK3"/>
    <dbReference type="GeneID" id="18470957"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26847"/>
    <dbReference type="HOGENOM" id="CLU_1215601_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJK3"/>
    <dbReference type="OMA" id="VANPNMV"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="21015" checksum="2DA8079CC74FB92A" modified="2012-09-05" version="1">MQDNTAKSADPAVTPSSQGQTQEDHRDNTSSHHKGKSALAPTLTIFIVIALIAVACLYWTRRRKRFIKEENERLEVETINSNEKDEKDLMFERMESPPPIYTRSSSLVPSTRNSGYDQEFTNYALTAPTVQFAQTQIPSRNTSVSNLSVSHTGRDSIRSDGLASSHHSSVMIPPKTYTPFEDTFVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM1</accession>
    <name>I4YJM1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1783-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_42329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955984.1">
        <property type="nucleotide sequence ID" value="XM_006955922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM1"/>
    <dbReference type="GeneID" id="18472247"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42329"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1662169_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJM1"/>
    <dbReference type="OMA" id="PAWYLNG"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18885" checksum="0B3E374AF654F677" modified="2012-09-05" version="1">MLKYQRFNRELPKNKNYYKQLSLLLSFSCLSWFGFIKYSNNQERLNSSIVKELIRQSKFHPTTRDVLGRDIRLYPNHWFLLGGLLGNTYVNGEISMMKGKIDISLDLKGSIDQGKIYFTSIRNSKHEKFQILRFKLIDNHNNHYNLIQDSSIKDFEQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJU1</accession>
    <name>I4YJU1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Chs3p</name>
        <name evidence="20" type="ORF">WALSEDRAFT_30938</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956051.1">
        <property type="nucleotide sequence ID" value="XM_006955989.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJU1"/>
    <dbReference type="GeneID" id="18471213"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30938"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="InParanoid" id="I4YJU1"/>
    <dbReference type="OMA" id="LEMHHQI"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1225"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1620"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1647"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1679"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="18">
        <location>
            <begin position="3"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="19">
        <location>
            <begin position="1874"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="583"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="788"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1851"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1866"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM24233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1932" mass="219217" checksum="19E1A3148CBA2C6B" modified="2012-09-05" version="1">MSNNMDDISKLRDTSDDAVLSYLRDRFLGDQIYTRLGTSSIVALNPLKYIPLNSDKVLHDYALEYRQTDKHVRLGPHIFQLAADAYYYMRRSSKDNNIILNGETGSGKSELRRLATRTIIDLSLPPPGKKGHKLGDQIPSAEFVLEAFGNAKTLHNPNASRFGKYTELQFSDRGRLYGAKTLEYYFERSRVVSPPPGERNYHIFYYLTAGASDEERQYLKLQDVGAYRYTSGAIRRRSGPLVGAKNGEDAARFSQLKNAFKSAGFSKRHVAQICQLVTAILHLGNLEFTIDHSRNADAAVVKNVEVLDIVSEFLGIHPDSLEGVLSYRTKLVKKDVCTVFLDVDGAAANRDDLARSLYSLLFSWIIEHINQHLCKDDFSTYISFLDLPGFQNVPSTGHRGNSVDQFCVNYLNERLQNWIFEHVFTRPYEEHKLEGISKISPPVSFSEYDNADVLRLLGAKQGGLIHIMDDQAKRAPKKNDNTMVEAFNKRWGNNSKFKTSSPDRSGYPTFSINHYAGTVTYSAENWIEKNTENLNPDFVSLFKGGVANDKTTNGSENPFIKSLFTSNAINTQFHPKSETTLVAAQQSVGPMRKPSTRRTGPSMRRRNNDTDLGDMPEDDVLDQQNPSNTNTCVATEFRNAADVLFDTLEDCYPWYVFCLSPNDAQLPNQLEARHLKAQIRASGIPAVARRAAVAEWAINMTHDEFVESYSDELNEMEIMQGDAVTKIINMREKMSWTERDLTIGSNKVFITHDVFRHLEDHIRSYDEQEQRQFNKYQKSEADYISAPDPFGPYATLGEESPSTPTSELMNDPFASRDHDVSTVALPLVTNSPRDMPDDESVDRKSFKSYGYNDSDGYRQSKYEGYDTPSQIGTEMYAPSQNMFSNMDLKERDRMLNEKDMFEVEQETQEEVKESAVRKRWVAFCWLLTWWVPSPFLKWFGRMKRQDVRQAWREKLAINIIIWFVCACAIFVIAILGPVICPTQRVYSQNEISSHTHQSQPDHTFVSIRGEVMDLTKLYGAHHGAVPIIDDKEFWNYGGKDVSNLLPVQVSALCNGIDGSVDPLVGLDASNTSSSEPNAHYHDFRAWTNDSRPDWYYEQMVIMRYNYRVGHVGLTDKEVSKMADDSSNVAIINGSVYDMTPYITFDGGFPGHGDNEVAPSGIDTHFMHDAIVQIFEQNSGEDVTKYIQDLDLDPTVLSRQMGCLRNLFFVGKVDKRNSPACKFSNYILLALSIFMIVIIGFKFLAAISFGRGRKPEEHDKFVIMQVPAYTEGEESLRRTIDSLACLRYDDKRKLIFVICDGNIIGSGNDRTTPRIVLDILGADPNYDPEPLSFHSIGEGNKQHNMGKIYSGLYECRGHVVPYIVLAKVGKPTERSRPGNRGKRDSQLALMWFLNKVHFDAPMNPLELEIYHQIKNVIGVNPNFYEYMLAVDADTMVEPDSLSMYISSFIRDKKILALCGETSLANAKQSIVTMAQVYEYYISHYLTKAFESLFGSITCLPGCFSIYRLRTTDTHRPLFIASEVIDEYSENVVNTLHLKNLLHLGEDRYLTTILLKHFPLFKTKFTADARAQTVAPDDIKVLLSQRRRWINSTVHNLAELLFLDRLCGFCCFSMRFIVFIDLLSTIIAPVTVVYIVYLIYLAAAEGKTIPTTSIIMLCAIYGLQALIFLMHRKWEQIGWMIVYICAIPLFSFFLPLYSFWHFDDFSWGSTHVITGEKGRKMLIHDEGHFDPKNIPLKTWAEYEAELWEQGDDIYEFQKGSRPPSPTNTVSIYGPQSMYGGLDQTGVPRSASAHQSMYRQSAMPSQYFSGYNAPSMYSLAPQQYPQSQQAWASGFYGGYDPRMSMNFSQGYMPQPTHSATHIPEDSRYSSSSGLIQSPSSQEIETEVRDIIGRADLDNITKKSIRQDLADKYGNEAINGRRAEINAIIDDILTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJY9</accession>
    <name>I4YJY9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956094.1">
        <property type="nucleotide sequence ID" value="XM_006956032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJY9"/>
    <dbReference type="GeneID" id="18475211"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67106"/>
    <dbReference type="eggNOG" id="ENOG502S6BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1807707_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJY9"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16369" checksum="253EC968008CB993" modified="2012-09-05" version="1">MTKTLTSKKEKDLKRKQQHSEIERNRRIKVNKRFDQLRELVSKDDMKAKPSDFKLQVLDQTVEYIHKLQDELRLLKSEESSRRSSSGDINSPSTSTPSNPFQTDETIVADVLVSLSTPESPFTKLAMANKIPEDLTLPPSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y576</accession>
    <name>I4Y576_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_58928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960845.1">
        <property type="nucleotide sequence ID" value="XM_006960783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y576"/>
    <dbReference type="GeneID" id="18473087"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58928"/>
    <dbReference type="HOGENOM" id="CLU_006019_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y576"/>
    <dbReference type="OMA" id="ERYPETC"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="508" mass="57329" checksum="6D1E208E05BDA5FE" modified="2012-09-05" version="1">MSSEHIRTHTRDNASDSELSQLVESMWLDDGTNSNPKPRSENLIDFGMSSNKGLFALVAGFIHSDRARPTSSSGKAEQFAEDDLVWKEPYNNDDFGSAELVYTLVESYFKYVNPTLPLFPSRRQFIENITAKKLDRDFGSVLILVCALGSLYRDNTQNNDNDSNTQLFDTYLQRYISKCPDPHLQISISIYNIQAIILAVLAMQNTQKYFRSCWSLCGLGVLLTENTRLRRLHTEESKRALWCLYVLDKSFAASYGRRALMAPLEIECPTTCDDEGINIVSHFNAMIKLYGIVGDVVDMFYAVNGSTNVDDLNEKLDSWRNNYISTTQLPSQFECLKVIGYNVVKIFINKKSLTSTSHNLEICVEAAKTILSTLHYMHCESELVVTYTDALLNWSVISATGIVMLKACRVCIDTSSTRDIQPQLQHLEIGMRVLRVKSRSDGVVRKALELFEQLIDVLQLHTRHSTLDASVTEWLGELVGSSASMSATMASSANLDAEWIEFLNEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5A4</accession>
    <name>I4Y5A4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960808.1">
        <property type="nucleotide sequence ID" value="XM_006960746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5A4"/>
    <dbReference type="FunCoup" id="I4Y5A4">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5A4"/>
    <dbReference type="GeneID" id="18474640"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61614"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011072_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y5A4"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="698" mass="78438" checksum="0C0E4258191535AD" modified="2012-09-05" version="1">MSMKPLPRNRKNPGLGRALINNQRKEPPKDSQMHTTDYAMSSVTQEKDLDEFLNTAAMAETEFTAEKDKNVTVIQHPSISGHNNPFLLSEEEEQKVKAKHDLKKDQLRLPQRPEWDSRTTPAQLDKSERESFLNWRRDLAMLVESDDSLLLTPYERNLNVWRQLWRVIERSQLIVQIVDGRNPQMFWARDLDPYTRRMGEKEVNWRTEGKLNVEGKRSLVLINKADLLDIEQRERWADFFDKQGIRYAFFSALNASELIEQLRVVRQVRDEILNADQVAQVAEEQERQRKELEVQDIVESAKENAVENGQHPPIESAEGYVSHARGLPVNVDQAIDAVSKLKTDDNEEKETVAAEATEPAPETAQQPESRRTRVLNIVELEQLFIDEAPDLSYLPAGHKLTIGLVGYPNVGKSSTLNALLGAHRVSVSSTPGKTKHLQTHLLGKSLVLCDCPGLVFPQFASTRAELVCDGVLPIDDMRDWRAPLELVARRIPKSVLEGLYGIKIETRPIEDGGDGIPTAEELATAFAVARGFTRQGSSGGNPDEQRAARIILKDYINAKLLYCHPPSGLNSEEFNAAMRRRMQARARGLGRRLIGSEQGKVQSMKSSSKTSKLDQNFFAQSRPVKLTPNVVGKANEQHGEFSRVQMYPHQGVVADDGTVLKGRKAKQAMAEAGIVVASSKKHFKGGKRTKKRSGQGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y623</accession>
    <name>I4Y623_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_41407</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960565.1">
        <property type="nucleotide sequence ID" value="XM_006960503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y623"/>
    <dbReference type="FunCoup" id="I4Y623">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y623"/>
    <dbReference type="GeneID" id="18472213"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41407"/>
    <dbReference type="eggNOG" id="KOG0666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="I4Y623"/>
    <dbReference type="OMA" id="YFKNGGP"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="354"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM19415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="392" mass="45195" checksum="8594DE53F7C9C3FF" modified="2012-09-05" version="1">MRDLNTIYNQRKLETQRNILDSYNILGFLSSGTYGKVFKATARDDTDKIYAIKKFKPDRDGEYSFTGISQSAIREIALNREIDNDNLAKLIEVLLVDGAIYMVFDYAEHDLLQIIYHHSQSLRQEIQPIVVKSILHQLINGVHYLHSNYIMHRDLKPANILITNKGVVKVGDLGLARIYRQPLQPLYNGDKVVVTIWYRAPELLLGARHYTPSVDVWAIGCIYAEMLSLRPMFKGEEARIDGKKLPFQRHQMMCIMDVLGYPNTQNWPGIKHMPEYNELQPPQTRFSYKLPNWFNQRSHSIKGFNLLHSMLTYDPEKRITAREALTHPFFVSEDPAPVKEPFVVYNQVSYPTRRLTQDDELTSNQNTNQTDTSARGSGPGGALNPRKRTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y695</accession>
    <name>I4Y695_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960412.1">
        <property type="nucleotide sequence ID" value="XM_006960350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y695"/>
    <dbReference type="GeneID" id="18475101"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66245"/>
    <dbReference type="HOGENOM" id="CLU_767693_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y695"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="361" mass="41932" checksum="FC73C2CA2869B4D3" modified="2012-09-05" version="1">MNSQKQSLKITMTQSNLIHQPKLHQSTNQTTDLLRRLDIKFCSYCLEKRHKSPQTHTDNECGHLHPELKGKHMKNKQLNRFERQRSINTPETKLSSQPQLSPANYRTLMTGRFSPDTAFFDQGSDVTCTCRLDLLTNIRQLNVPERFGTLSGESNSSLVGTMQLNLGHKNGTINWIETEAYYSPHYNSTILSKRLLEKYKLYLYYKPPYIKLPIPHYRHDTHTEESVVQTSPNANTDDTPAPASFKTIYDRFDKQEEFPNEYLGFNHSSKCKAPPTRVKGTLIQPGQAKQAARVFKQQEDDRLSKAEDTKTGIHYDHFQEQWSQFNDDKKRIYPDPEFYLPPPGAQVRESNSYKESIKELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D3</accession>
    <name>I4Y6D3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960449.1">
        <property type="nucleotide sequence ID" value="XM_006960387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D3"/>
    <dbReference type="GeneID" id="18474530"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61430"/>
    <dbReference type="HOGENOM" id="CLU_1519035_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="177" mass="19979" checksum="357CB493DC3C0159" modified="2012-09-05" version="1">MMRQYFHVDGLDFNEVTRSFLLSNVRGYIRGYGLTTRQMVVVTKFAFSYPITHIDCTPDQIGTMAWRMADTLGIGGTIWPNYEPNYEPTNDNPFPSSDFAINSGIINDGSDSIIIDEEQYATLFDNIAEPVSHGPQTRDLDYSCIGRDIWYAKDYRGVSSYAISTDTQGECVPNLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K7</accession>
    <name>I4Y6K7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_66233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960397.1">
        <property type="nucleotide sequence ID" value="XM_006960335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K7"/>
    <dbReference type="FunCoup" id="I4Y6K7">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6K7"/>
    <dbReference type="GeneID" id="18475098"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66233"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2335243_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6K7"/>
    <dbReference type="OMA" id="DYAMEQA"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="10293" checksum="7E7C30514E9AAFB4" modified="2012-09-05" version="1">MSDLKAQEEQLKSKFGHLKPKKGAPGALLGANKGRQYFDSGDYAMQQAGVKTSSEPVGTAIPKPETIPHSSPSANSNALSSSPNSGQQPRERRGSGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6N8</accession>
    <name>I4Y6N8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_48739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960293.1">
        <property type="nucleotide sequence ID" value="XM_006960231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6N8"/>
    <dbReference type="FunCoup" id="I4Y6N8">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6N8"/>
    <dbReference type="GeneID" id="18472463"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48739"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="InParanoid" id="I4Y6N8"/>
    <dbReference type="OMA" id="KTTKIWF"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="459"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="499"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="601" mass="67845" checksum="167120F7EB48B269" modified="2012-09-05" version="1">METTTEWDDSVSNNANNSNTLPVLLSFPHLLNVYPTLSTATQSHILLNLLRLSDISSIRNVNDFIKPALQKDFIGQLPLEISSLILNFLDIRDLARSASVSKTWKKIVDHDRAAWKAAGIRADLWFGDEEHLANKRQEVYLSANRTRHKERLNMEKESDTEMDGTRTPLTPPPMSNINSSSESPKKLTNTWKYHPYKHILKKRHTIRQNWFNNEPKAAYEFERHGQNVVTCLQFDSDKIVTASDGDDKSIDVSCTKTGRLRRRLRGHTGGVWALQYIGDTLVSGATDRTVRVWDIPSGRCTHVLSGHYSTVRCLAIIMPKYNNLTKEYEPPYPIIVSGSRDFTIRVWRLPSPTRDQTWDLNDGDANTENNPWAMKLLSGHTNAVRSVAGEGKTLVSGSYDFTVRIWNTITGDVEHVLRGHNDMVYKVVLDAPRNKCASGSYDGSVKVWSVDRGEQLQSLDGHSSLVGLLGLNSSSLISAGADSNLKIWDLMSGDCQHVLDGHDSAISCMAHDEQKIISGSDGMLKMWNAKDGKLKKDILSNLMHIWQVSMSDRYLVAASNKMSGQTFINVFDFGVVDEEDEEIEYSRLNWEPQWWVPVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R8</accession>
    <name>I4Y6R8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_66164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960322.1">
        <property type="nucleotide sequence ID" value="XM_006960260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R8"/>
    <dbReference type="FunCoup" id="I4Y6R8">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6R8"/>
    <dbReference type="GeneID" id="18475087"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66164"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6R8"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122114" checksum="9B958AFBE86F5450" modified="2012-09-05" version="1">MDAILDFSQDLDVGLLDRIVAAFFAGAGQEQQMAQRVLTQFQEHPDSWQRVPAILEMSPNPQTKYIGLQILEKLIQTKWKVLPVDQQQGIRNFIVNAVIKTSEDEAVMRREKTYLNKLNLILVQILKQAWPRDWPSFIPEIVTSSKTNLSLCENNMIILKLLSEEIFDYSAEQMTQAKTKALKNSMCGEFSEIFQLCSEVLEKAVKPSLIKATLDTLLKFLNWIPLGYIFETNIIDMLISRFLEVPEFRNVTLKCLAEISSLKVTPEYDAKFVLLFNMVMTIVNKMIPPSTDIAGAYESSNDSDQELILNLALFLTNFLGSHLSLVETPENKDVLLNAHLYLVKISQVPEREIFKICLEYWSVLVAELYDEVQHTPMAEMNPLLGLNMNVAGASGGQNLRKNIYNEVLSNLRLVMIERMVKPEEVLIVENDEGEIVREFLKESDTIVLYKDMRGVLVYLTHLDVYDTETIMTEKLAKQVDGSEWSWSNLNTLCWAIGSISGAMNEDTEKRFLVTVIKDLLGLCEIKRGKDNKAVVASDIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIAQKCRRHFVMQQSAEQEPFIDEILRNLHRITIDLAPQQVHTFYEAVGSMIAVQPNKPVQENLIAKLMDLPNNAWDTLMQQAASNVDVLSVPENIKILSNVLKTNVSACSSIGSFYLPQIGRIYMDMLGLYKAVSGVISETVAAEGNIATRTPKVRGLRTIKKEVLRLVETYIKKAEDLETVNANFIPPLFEAILLDYNRNVPSARDAEVLNVTATIVNKLGPLLTEQIPPILDAIFECTLSMINQDFAEFPEHRVGFFKLLRAINYHCFPALLQLPPSQFKLTMDSVVWAIKHTMRDIADTGLNLALEVIDNIVKTDTSVANAFFQTYYLSLLQDSFYVLTDSDHKSGFKLQSVLLARLYALVSKVGISAPLYDPAQVDPSTSNVIFVRDYTANLLANAFPHLQPVQIQSFVTGLFELHEDPARFKLHLRDFLIQLKELQGDHAGAPAIEQANAPGAAAIEFEQQEEERKQREAARNAVPGMIKPALLEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T8</accession>
    <name>I4Y6T8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960341.1">
        <property type="nucleotide sequence ID" value="XM_006960279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T8"/>
    <dbReference type="GeneID" id="18475091"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66181"/>
    <dbReference type="HOGENOM" id="CLU_2160360_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12110" checksum="DE3B81A1230142D3" modified="2012-09-05" version="1">MHAIGLAQSGTIALHSAFVGTTFSSKRSLKNKCVKALFDFVDDKDNVHYRGIAEVYNNGDVSVFPMTLNAYNHGIEGATGHLKDLGKKTAQFTIDYDTKWKAVVGIDVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y759</accession>
    <name>I4Y759_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_70323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960135.1">
        <property type="nucleotide sequence ID" value="XM_006960073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y759"/>
    <dbReference type="STRING" id="671144.I4Y759"/>
    <dbReference type="GeneID" id="18475715"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70323"/>
    <dbReference type="eggNOG" id="ENOG502S5GS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842521_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y759"/>
    <dbReference type="OMA" id="YNPFAQR"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="318" mass="37399" checksum="A8C7F1E12BE1BBA3" modified="2012-09-05" version="1">MSENNGYYNYWQNNEQYYHWYYIQQQQQLQNASVGGYNAAYYNYYNNQQFYPQQQQQQQQPHSKPKKQKQPQQQQSKQLHRCSQPDCFITGSKKEVEIHMMDRHLIYPPGYLENEARKKASKPPKPTVPVEGTNIMLDTPEAIEKWILERKKRFPSAANIAEKQKEKEDKIARGEIPLDPKFTGKNKRSTNWHNDDKKRNTTKKPRLHISEETNLSEQEQDDDQAPESASSKIPTRMPPSKLLSQPRIERKKLEPRQKAANNQFQQPNLMAKLFNDEIRQSVSYLSQTIRFLVANDCLENVETQIGEAEKPDLLTEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H0</accession>
    <name>I4Y7H0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_40683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960053.1">
        <property type="nucleotide sequence ID" value="XM_006959991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7H0"/>
    <dbReference type="FunCoup" id="I4Y7H0">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7H0"/>
    <dbReference type="GeneID" id="18472186"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40683"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7H0"/>
    <dbReference type="OMA" id="NWEDERD"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="25403" checksum="FEAE84EE072972A6" modified="2012-09-05" version="1">MSTEDIDREVSREAQRINQEIEIERILRSFKLNPFDVLDIDYGIDEKSIKAIYRKKSLLIHPDKVKHERAVEAFDLLKKAESELSTPEKRYKVDCVVSDARMFLIKDLKLPLGVHDDHPSIKALHPPFKLQVKEKMKQLMIEDELRRRRAIKTQLANEGAEARKKDEEIDSKKRKAEEKKEWESNRDNRISGWRSFQKGDKEKKKRKKDKINVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7L9</accession>
    <name>I4Y7L9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_65911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960099.1">
        <property type="nucleotide sequence ID" value="XM_006960037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7L9"/>
    <dbReference type="FunCoup" id="I4Y7L9">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="18475068"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65911"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017517_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7L9"/>
    <dbReference type="OMA" id="KRSECGN"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55641" checksum="56740DBD4537832C" modified="2012-09-05" version="1">MSTNNPFPNGPLRVEDPSTGIANLNSAIPLVQETKSRASQVYYLWPCYGLYAMAVGMTFAPNLEVRSKIICQSYTLDSNANCDAIPNFKNEVAHLTIILSLITGVLACLTTSYWSAFSDKIGRLPIITLTSAGYFIVNGINAYVSTRLDPNQMYLLYISAAIEGLSGSQSTVMALSHAYASDCTDNGSRAHVFSQLMGILFLGVAAGPALATFITKYTEHFENAFIAASVLSIIMLIISLIIPESLERKSDLDTSLPERQSAAQTIRKMPSIVDNIKKPFSIIAPQRDDNDVIKNVNLLAITLAYVPIVLAIGSVQIKFLYTKFKFDWDVNQLGSFITYVGTVRALALLLIIPLSLETLRRFMKPAIELPTTTIYEDEDEDTINDEILTKSVNQAEIKFDLVLLRFCLAIDAIAYAGLAFSGSVTTFSAFTAMSAFGGGASPSAISSLALLLAPKESESNGAVLGAFSSVQSAGAQIIGPALYGFIYAQSPNSAFMFVIGGTFIASIIATFFVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R7</accession>
    <name>I4Y7R7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959939.1">
        <property type="nucleotide sequence ID" value="XM_006959877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R7"/>
    <dbReference type="STRING" id="671144.I4Y7R7"/>
    <dbReference type="GeneID" id="18473016"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58408"/>
    <dbReference type="eggNOG" id="KOG2709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023639_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7R7"/>
    <dbReference type="OMA" id="ERRDWMI"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="204"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="412" mass="43723" checksum="AB56D3B1AD6F070F" modified="2012-09-05" version="1">MENNQAVILISFNGTTAYQSYDNQRVPLSTGVLDLSLVSVNSTINYDNPTEIFDTNKTSGADYWLVLSIRSEKAQPFEMALPAAIPIERISDRGYSIPSPTLPDAFIELELPEKYSHDDKESFDVILGSYASLPVTEEQNDLRGKLCLVDTQDGHVLGSLDAAGTAVEDSSLTEKGNEKQPVVVDLPEQPQDHLKVTAAKDPSLMIRSSNYVSQAIIGGGNLLGKGLAAGSSTFVARTKAGDKPLVFSENQRKNAARVHNVTGQVANVSAKTAGMIADSARGVGAYITGKGKKDDERNADKKPGFLNRAFMAADNVFTSVEQAGKTLINDTSMATSVMVAHKYGQDAGQAVRGVGDSVHNAALVYIDVRGISRRALIKSAGKGALFGNKQSGSSSPSLNASPTPPPALPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y810</accession>
    <name>I4Y810_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959823.1">
        <property type="nucleotide sequence ID" value="XM_006959761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y810"/>
    <dbReference type="GeneID" id="18474346"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61125"/>
    <dbReference type="HOGENOM" id="CLU_2322170_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y810"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="99" mass="10857" checksum="AF75FD719C17DA45" modified="2012-09-05" version="1">MTRSPDSEGDKSENSFYSNRVGSQEEVRKPGDYFETTGPGGLGVVRVTKGTPVSEEIRKAKAEGKLRPIPNINRLLRGSTLVIMIFFVVLTCLIPVTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y821</accession>
    <name>I4Y821_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_21072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959834.1">
        <property type="nucleotide sequence ID" value="XM_006959772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y821"/>
    <dbReference type="FunCoup" id="I4Y821">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y821"/>
    <dbReference type="GeneID" id="18470874"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21072"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y821"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="222"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="487" mass="55219" checksum="07133F2EE0A90902" modified="2012-09-05" version="1" fragment="single">NSANLCVGCLRNTVDITAEIPKSSSVTFCRGCDRYSNPPNGWVLADWESRELLAICLKKLKGLSKIRLIDAGFVWTEPHSKRIKVKLTVQKEVLANTILQQVFEVTYTILGAQCPDCTRMAAKNTWQTSIQVRQKVPHKRTFFYLEQLILKHGAHKDCVNILERKDGLDFYYLQRQAALRMLEFLQNVVPLRYKASEELLTTDVHTGSSKYKFTYSVEIVPVCKDDLVCLPIKLARQFSNISPLVLCSRIGNSVHLLDPMTLHVTDVTAPTYWRAPFETLATVGELVEYIVLDIEPLGPTRGKLVLADVQVMKASGGASDDEIFHTRTHLGHILQAGDSCLGYNLKDSNFNSDNFESLNQDRLPDVVIVKKAYPNRRKKNRPRQWKLKSIAKDAEDSNVEGAFGRGALGRRGGVDTDKVEKQYEEFLNDLEEDPEMRAGVNLYKSEEQQTKDENEMDESDGGELEEDENLPKMDELLEDLEEMNIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y898</accession>
    <name>I4Y898_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959678.1">
        <property type="nucleotide sequence ID" value="XM_006959616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y898"/>
    <dbReference type="GeneID" id="18474304"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61044"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267776_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y898"/>
    <dbReference type="OMA" id="ARYNDAP"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="218" mass="24696" checksum="84FE7A340747A647" modified="2012-09-05" version="1">MAKSELDDAAQHRRHKLGKRTRKDKLRKFLLHSAYVPLLFRSVNVGFTTASLAVCVRIRILEGQFNALGISGAGAIIGIIFAPMTLTHVMVSIYLEYFYGRPIGIWGIRSKMAHTLLDLVFIIFWSAELSLVFDNYFTSLLSCSNTTPWWSNVSQANERTADLILSDEKQGRLCNHLGALVGLVFVGMLLYVVNLVVSLYRIYERVRLHQHMHNGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8G3</accession>
    <name>I4Y8G3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_40237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959743.1">
        <property type="nucleotide sequence ID" value="XM_006959681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8G3"/>
    <dbReference type="GeneID" id="18472161"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40237"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y8G3"/>
    <dbReference type="OMA" id="YCDIHYD"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="351" mass="41331" checksum="84B934455EF99A7C" modified="2012-09-05" version="1">MFKKPINLISIFIIFLLIFLLSYLNFHNSSSTPTKSAFVILTTNDDLPGILQSIRHMEDRFNKRKSGGYDYVFLNDGKFSNKFKKHTSSLISTNAYYGKISSSDWNQPKWIDEDRASAVRTKMAIDGVLHGDSISYRNMCHYFSGKFYNHPLLRNYDYYWRVEPDVKYTCNLDQDPFLALEENNAKYGFTIAIHEYPETIPTLWKAVKEFMDLYPQHIAPDNSMDFISDDKGFSYNGCHFWSNFEIGDLSFYRSQAYTDFFNFLDRKGGFYYERWGDAPVHTMAAALLLNRDEILRMDPIGYYHIPYNHCPLGFKNYDRCECNPLETSDYHPHSCAIKWDKFANHRKWEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8G6</accession>
    <name>I4Y8G6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_40239</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959746.1">
        <property type="nucleotide sequence ID" value="XM_006959684.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y8G6">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8G6"/>
    <dbReference type="GeneID" id="18472162"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40239"/>
    <dbReference type="eggNOG" id="KOG0388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_20_0_1"/>
    <dbReference type="InParanoid" id="I4Y8G6"/>
    <dbReference type="OMA" id="FWKKNER"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="127"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="398"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="976"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1151"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1190"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM20258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1300" mass="148869" checksum="E42E632C99641B4E" modified="2012-09-05" version="1">MDDYINKFRLNLVNHQQQLQQNFDYDRISLLNTTHNDLSLNYQQSSITAAHESKKRKQAIVQQSPQHKKQRLPAPPSPPSEQAPPSPPQPPVQQLNIPEYQGLDADYCLPTTALERAKQVEDAQTAIWLHISRKEIPKAYKYSTSTYTSHLSFHKRISLLTQREQRKLTTRTTKSNKEVQAKAKKVMREVLFHWRRNEKDERDVRRKADREAYDRARAEEQSRESKRQARKLNFLITQTELYSHFVGNKIKTDEAEQSNDTAGDPNLEQSGTPIQPPQFDFRKFDESNLGDIDYDDEDESNLRMHAAKNAQQAWLNTRDKANQFDKNAAEDRRKNEAIQKAREMGVEVPPEAEQAPLENDELNFQNPNLGEDSVQVEQPKLLAAELKDYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISLMAYLAEKHDIWGPFLIITPASTLHNWQQEISRFVPSLKPLPYWGSTKDRAALRKFWQRKAITYTKDAPFHVLITSYQLVLSDEKYFKNVKWQYMILDEAQAIKSSQSARWNTLLSFKCRNRLLLTGTPVQNSMQELWALLHFIMPSLFDSHDEFAEWFSKDIESNAENKGAINDNQLKRLHMILKPFMLRRVKKNVQNELGDKIEIDVHCDLSQRQRALYRLLRSRISITSLIEKASKGNDEASKRGLMNLVMQFRKVCNHPDLFERADVKTPFVMSKWSRYKSTREPDVHYCPDQFESLIDLKLPRLIADDVEIGGGAGTPEGRSKFGSNKLQSLFNIWSPDYILKSMLKENSPFAFLPQAGISADEAARIFSTTEFSRLLLAYNKAIAQNEHQGYNDDDDLIASTLNKKFNITRPFPYKTDVEEYGDKPLPKLNEIASNMISSSVLLRRSSKYMSGIKRVLAPSPYPYILHRPSLDRIEWRTKQDDEINKAFFGLQTTHLKENTKAVESLPPNIPPAGLVENSDRIQLPPSTMTVPEPNKLIIDSSKLVALDELLPKLKAEGHRVLIYFQMTKMIDLIQEYLIYKGYKYLRLDGSSKINDRRDMVQAWQTSDEYFIFCLSTRAGGLGINLTAADTVIFFEHDWNPSNDQQAMDRAHRLGQKRQVTVYRLITKGTVDERIIKLARVKKDIQDMVVGQKPVGEKENSGPNEREIIQMLMEEDQDPIEADIMGGSNDLDTELLNDGTNLDDDGMFNGEASNNNTGNGTPMSTPSKTSTPRPGSRPVGRPPGSTNKDRTPSGQISQDGKPKKRFRRTKKQMEEDAAAAAAHEAYLIKEGIAPEKKKRGRKPKLQVEQEAQAQRQFEELQARNAMASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J8</accession>
    <name>I4Y8J8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959778.1">
        <property type="nucleotide sequence ID" value="XM_006959716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J8"/>
    <dbReference type="FunCoup" id="I4Y8J8">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8J8"/>
    <dbReference type="GeneID" id="18474330"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61094"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004825_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8J8"/>
    <dbReference type="OMA" id="VTWPAFV"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="102"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="560"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="123068" checksum="9C00309A3075EF7A" modified="2012-09-05" version="1">MQRKSLKRFLVLVLPPVLSSFICCLFIVIKPISRFAGDQFSFLLFTLFNLFFYPNGSIGSQIELTVLGLIFGVIGLGISNLSIYFTILVNRETIDHTFARTIPCVTLTLVAFVAAYARSKLPRLMVASRTIQFVSAWSLTSNLRAITMSPRTFLDLWWPLLWGSLIPLLVSMICFPVSARQQFSKEVIQALQDAEDTQAASYRVLFSTNEIDTPLANLTRLRTQFFKNARRLPALLDECLFEFSYDYVGVDNIAPFVGIVNSLRVSLANGSNDLIDTSMYNKDNSNKDILGLSDDADDDLACVEDLKNLITIMHQAILNSLSLVRRVLRTALIVKDFSEVGVDDIDLQKQLLTQAVTNCRSEMHNILVKNLANNPSDCSSLFKKHLCMLSYYSVTLFKIAADLVFALTCVSDVLSSRLKNHRKIHYPRNFWSWLKAPSTTINDFGMKPDGNDDFLSVEQKEENRHKHTFEEEMQLQAYAAYAIRRSRLKQSGFSIKYWFLNIWDAPKVLKSRLAVARSFRSLRSSRHIKFALKNAAGVAVLSIPCFLPYKSPGQLWFFENKGVWMVISYFYVLEPSTGATYRVGLWRLTGTILGAVYGFIVNMITKGSSIGITAMVTAASVLIAWLVRMSSVPGVGTVFAVTFPPIIFPVYLDTASFASFTIALTRGYMIAIGIIAAILVNLLWWPFHARVNFTLQVSKAISEITKLYLILSRQTLGVTTLAASRTQFNITEKNVQAALNACDTLLEPLRLELSIIPKPVTLYRKMISSLQRTHDLLVSLRYVRERIQKETVIEIKDQRLNFINALVLVFYASMHAFRSSTPLPQFLPSLYTALNDMLSAIDNKLIEILSSDEMVLRRQLSSYRLHYALSEAEILLGLVTSMEEMLSIAKSLFGQTSIFDELPSDEKGDTENLDSLPLHTLGHTGWSSGPTSPTMQIMTSPAKKLSLKHRENDVVEKYSKEYPGNAYILNYSPPGASGSPPLSKDTSMLSISELANKESKDGNDNKDNKGHDKLPPRTHSKRSNRNIEGIPLARDLFQQASSSTSSSPVDQQNYRSRQSSLTSARTSPIENTNHYRTRTRRKDSDSSNSSNTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R0</accession>
    <name>I4Y8R0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959609.1">
        <property type="nucleotide sequence ID" value="XM_006959547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R0"/>
    <dbReference type="STRING" id="671144.I4Y8R0"/>
    <dbReference type="GeneID" id="18474285"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61013"/>
    <dbReference type="eggNOG" id="ENOG502QZS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439541_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8R0"/>
    <dbReference type="OMA" id="EEFANVC"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="2">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="622" mass="70297" checksum="344CA4049E242557" modified="2012-09-05" version="1">MTSANDEQTLNRVFSLDKPYTPTTPSFSTTPRISSRQMLNNALSLANTAVNLDKDNDFPKALHAYKDAMDLLENVMRRVEAENSTNSSQQKPTSRRLEEARRLKIIHETYKDRIRLLEVLLDTNEVQKALVNSPIDEKSELENKPPQNQSSPTSSVSSPHKTASSDSHLNSKSMHTPSIEFTQVSPQQPKTRHVTTPSISIQPGSPLEPPVSTERSDSNQTLTDSPRRPPMNRSRSSSTNSSYKLPTRTSSMASLSEKHQIVPLINSSVGEGSLLQRRQANKSNETELFETETTKAFKLDTLDSQRPQNNTAGRLRAISQPNTRTSVSLSRNQSIPPSLPLNTINDNRNINLTQNIDRINLFKTLSNNLYATSEPIIPDPPSRGKPSFDWYHSDPTRRPFQLMKLLAKSIREGAYISPRLYVSPQIWLDSRNVVKLNHIEVKVKSLETILEGLFEVYTIGKNFVQSQVEDEIFLNALWGFNKTLDEVQNQLEKKLDLSSYSNNNFSPTQSSTNNKSSNWTTKLSRSLGVSNGRKTEEGWLYAYIDLLNKVFVNAQVLDVHFGYLQNDVYELYKDSTIEIRHSIAKSLQQSSIIFSRSICKFVLTDLDVLIGKWTKRSHGVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U7</accession>
    <name>I4Y8U7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_20819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959645.1">
        <property type="nucleotide sequence ID" value="XM_006959583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U7"/>
    <dbReference type="FunCoup" id="I4Y8U7">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="GeneID" id="18470858"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20819"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8U7"/>
    <dbReference type="OMA" id="WHVGRFS"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="39183" checksum="C9806A95F8419756" modified="2012-09-05" version="1">MTAKYQALFKPKNLGQLQLQHRIALAPLTRLRTKGDGVIEDYVPEYYQQRSTKGGFLISEATLIAKEAGSAYGKLEPGLWSNEQLEQWKKVTKSVHDKGAYIYSQLWALGRIANPELSERLVGPSAGTYQGNKVEELSVEDIKRYVNHYKQAAINAVETAGFDGVEIHAANGYLIDQFTQKLTNRRTDEYSAESLKFPSEVLEVVVNAVGQERTGIRLSPFSTFQEMRDENPLATFTSWVEKIVKTYPKLAYIHFVDGTTPEDQRDGNKLKDIIRDAGIAVISNNTYNLDEASKRAEERDEIIAFGKYFIANPDLPDRAAKDLPIVKADVNTFYGGGRNGYTDYPFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8V4</accession>
    <name>I4Y8V4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_47804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959652.1">
        <property type="nucleotide sequence ID" value="XM_006959590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8V4"/>
    <dbReference type="STRING" id="671144.I4Y8V4"/>
    <dbReference type="GeneID" id="18472428"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47804"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y8V4"/>
    <dbReference type="OMA" id="IGSGHYE"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF40">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="99" mass="10781" checksum="91B899C4F24CF8DB" modified="2012-09-05" version="1" fragment="single">MVKSTDILLMVVTILFPPAAVAFISGCSCDLLINVGLSLLGYLPGHIHAFWLIFKRMAAEEKYGYKGFRYLGSGKYESIDGLTTEPHQPPPAYGATDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8V6</accession>
    <name>I4Y8V6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_20801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959654.1">
        <property type="nucleotide sequence ID" value="XM_006959592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8V6"/>
    <dbReference type="FunCoup" id="I4Y8V6">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8V6"/>
    <dbReference type="GeneID" id="18470855"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20801"/>
    <dbReference type="eggNOG" id="KOG1697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036531_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8V6"/>
    <dbReference type="OMA" id="RESAMWA"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="325" mass="36536" checksum="7ADFA6A0E2753FE7" modified="2012-09-05" version="1">MLRRVFVGASKRPLSRCISSTSLLKQQTSYVPRNAPVAPLNPQLKPTNSYYYTGRPLFESSIANLENLKRDSQRSISLALALPTKKLHLLRSQNDTGVIFKWLSQEAVEKKLETHLKVSEYRRLVDLLNSITKLLPAARSGGSQTAQIVNDIEVAVREFEPPGGREVQVGQRKPVEIDELGRSYTVGRRKESSARVWLVPTSPEKEVRNTEILVNNLPIYEFFPRIHDRESITLPFRVTGQLGNFNVFGLVRGGGTSGQAAALAHGIAKGLLGQIDQRLGLESDDDRSVKRTLKKAGVLLRDPRQVERKKTNLVKARKQRTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y912</accession>
    <name>I4Y912_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Origin recognition complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_65360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959480.1">
        <property type="nucleotide sequence ID" value="XM_006959418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y912"/>
    <dbReference type="STRING" id="671144.I4Y912"/>
    <dbReference type="GeneID" id="18475013"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65360"/>
    <dbReference type="eggNOG" id="KOG2543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642829_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y912"/>
    <dbReference type="OMA" id="QLRRWHG"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC5 lid" evidence="5">
        <location>
            <begin position="185"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="4">
        <location>
            <begin position="270"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48647" checksum="0FE2FB309C21FD5E" modified="2012-09-05" version="1">MEQQRKAIASKIGLFLEEDIPSPQSIFIQDSQSIDFTIEFLRDTLPSQTPFISTSEAYNARLVVERILTAYNVDGASTNPVERLIDGLSNFQGDFTKRYIVITEAHRLKNYDNLLIPLLRLPEIIQLPFTLIMTSKQPFTTLRPTNGLSPDPILVNIPPVSSKDIYDYLIQNCPSDVGENLHSTYQALCNFIMSSTTALNTQPKELLKITRRAWPKFIEPWTERDARPTMRDNELLTLTFARASRGIIQSINSNLPDNMDLLQASLPTDLTRCAQLLLIASYLASYNPPKQDVQMLSISLDKQKLVHRRKDAKSRPAQQLLGPKNFSFDRWLHIYGALLHFINDTSLTAYSLTNLKNDHRVFTDNELGQVDVLQNISHLTRIKMVQRTCPYERLDGMTFKCAIGYHVASNLANSFGVKLHEFLWDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y937</accession>
    <name>I4Y937_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_39897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959505.1">
        <property type="nucleotide sequence ID" value="XM_006959443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y937"/>
    <dbReference type="STRING" id="671144.I4Y937"/>
    <dbReference type="GeneID" id="18472141"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39897"/>
    <dbReference type="eggNOG" id="KOG2131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008742_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y937"/>
    <dbReference type="OMA" id="YESMCAK"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="32963" checksum="A65BD187A113AE46" modified="2012-09-05" version="1">MRVDDAITRMLDGERLYIKDWHLALRTQSDFYNTPAIFFDDWMNDYYSRHTDDDFRFVYAGSASTFTGLHRDVYRSYSWSANIVGKKRWVLFPPHTERYLRKEPDNPASEIVYDVRHVDRKTFKDFDKAEKDSIVIIQEAGQIIFIPSGWYHQVENIDNCISINHNWSNSNCLLDMYSSMKEEYLAVESSVMDIKDILPNKGEWYEVVNDLFAKSSGWNWITFFAMLTTALENTDQDHRPDKKITERKIKLVAAYFREEYKDMIDSDDRLCNKINQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y947</accession>
    <name>I4Y947_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959515.1">
        <property type="nucleotide sequence ID" value="XM_006959453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y947"/>
    <dbReference type="STRING" id="671144.I4Y947"/>
    <dbReference type="GeneID" id="18471655"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33335"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_6_1_1"/>
    <dbReference type="InParanoid" id="I4Y947"/>
    <dbReference type="OMA" id="VMDIDYA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="314" mass="34803" checksum="A8C0600B79B84069" modified="2012-09-05" version="1">MISRAFKLNRRSLVRNYGAAATPFRTHFGGEATPTTSTFYDKASSTWTYVLHCKDTRKAAVIDPVLDFDISSGKVTTESADALLAFLHENQLSVEHILETHAHADHLTSAKYLQKHLHAPISIGQRIREVQATFGPRYGLKPDSFVGSFDRLLQDDEIVSLGNLKGKVMHLPGHTPDHVGYVFGKSVYTGDSVFLAPVFTARADFPGGVASSLATSIEKLLSLPHDYKLFVGHDYPGAEREQSCWTTVGDQLTLNDHLKQEDFAKFREERDKTLNTPKLLHPAIQVNIRGGRLPPSDEDGISRLKLPITTNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9C7</accession>
    <name>I4Y9C7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">WALSEDRAFT_69721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959361.1">
        <property type="nucleotide sequence ID" value="XM_006959299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9C7"/>
    <dbReference type="FunCoup" id="I4Y9C7">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9C7"/>
    <dbReference type="GeneID" id="18475628"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69721"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044783_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9C7"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="60"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="24755" checksum="A4193304F3DC0174" modified="2012-09-05" version="1">MSSVEDLPSSKLGTKEHWDEVYEREVENFEEIGEEGEVWFGEDSVEKMIDWALDNVPSEESGPTVLDMGTGNGHLLFELVSNGYQGKYLKGVDYSPASVKLSNQIAKSKGDNFEEVAFDVVDVLDKQQISNLGQWDVVMDKGTFDAICLSVGSNRLLYAQQAAELVKKGGKLLITSCNFTEEEVKSTFEADMKFKYDSRVNHPTFSFGGSKGSTICTVAFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F6</accession>
    <name>I4Y9F6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_29518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959387.1">
        <property type="nucleotide sequence ID" value="XM_006959325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F6"/>
    <dbReference type="STRING" id="671144.I4Y9F6"/>
    <dbReference type="GeneID" id="18471103"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29518"/>
    <dbReference type="eggNOG" id="ENOG502QVK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009026_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9F6"/>
    <dbReference type="OMA" id="SAVMVCD"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="270"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="379"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="459"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="818" mass="88731" checksum="7CC0ADF64151FA53" modified="2012-09-05" version="1">MSQSAVSAGHESPLSDNRRKRNHQKDENNSPQNVDFPTQDTPQNAPESKRSKKFFGALGRSRKSSGSHKRTLSSSTKSSQPLTTTNDNDKSRQSTHSISNTDQDSSILPQSSTSPSITTAPTTAPSHTRSRTVSSTYPPSKIHAEPTRTSSNSHGIGGKFQALRKKIETELGKKRPGSSNPRRDHHGRDRKRNNKQPGTVASLRPSPALTVPDSMTVADASQLCAAKRTDCVLVVDDEESLCGIFTAKDLAFRVVAESIDTRHTPVSEIMTPNPMVTRDSASATEALELMVARAFRHLPVCNDDGDVVGLLDITRVFNEALDKIERGYGASQKLYNALEGVQNELGGNTNSRQAAAMMNYVDALRERMALPDLQSVLDARTHPATVSVRTTVREAARIMKQYRTTAVCVMDNPISAGTGGHLNSQNQPRIAGIFTSKDVVLRVIAAGLQPDRCSVVRVMTPHPDRAPPSMTIQEALRKMYTGHYLNMPVVEDDGKLIAIVDVLKLTYAILEQINSMSQEQQNETGEEASGPMWGKFFGTLAAAPDDNDSVVSGSRDVASPQGGRNDSELHPNDSASVVDHSVDHDASQIGIDHASSGVLESEAANGVVDEHIAVFKFVSPSQRIHRFESPTLSLEHLRDIVAGKLSTDPFFTQHTEKAPVEDENPAPAPDPYDFSLLYEDDDGDHVVMSADSDVKDAVFVAQKKRQTRVLLIVNGGKGWETVDVVKPADDKPAVVIKEENIHQSEAVEEVETLEKKIEKETNQQLPHEAHTSLPSNKSTGPADGEVFGIPRDLVLPAAIAFAGSAVLIAFIGSKFASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9J1</accession>
    <name>I4Y9J1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_65298</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959417.1">
        <property type="nucleotide sequence ID" value="XM_006959355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9J1"/>
    <dbReference type="FunCoup" id="I4Y9J1">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9J1"/>
    <dbReference type="GeneID" id="18475008"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65298"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9J1"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="480" mass="54043" checksum="2EDDB3BB746800AB" modified="2012-09-05" version="1">MAETKTGQLNLPKSGQVEEDTTKLQAGNRSPHTLMADQFESMEFGAPEGLDISEPAKSPTPSTTPQISQSQLSAESKDTAQVITPWDVQGAVVDGKNVAVDYDKLIVQFGTRAIDNTLLERFEKLTNRKPHLYLRRGMFFSHRELDRILDRYEQGKPFYLYTGRGPSSNSMHLGHMIPFMFTKWLQEVFNCPLVIQLTDDEKFLFKGNLKVEQTQGFARENAKDIIALGFNPEKTFIFSDFDFVGGEFYHNVVRISKLITYNQAKAAFGFNESDSIGKVHFCSIQAAPSFSNSFPNIYGKKHDIPCLIPCAIDQDPYFRLTRDVAQKLKYPKPALLHSKFFPALQGSQTKMSASDTSSSIYMTDKPNEIKNKVNKHAFSGGQALAEDHRKYGGNPDIDVSYQYLGFLLDDDEEYERIGNDYRAGKILSGEMKKICIGELQKFVANFQESKAKVSDDILKIFMDPSKTIDGFEGLTPPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9L0</accession>
    <name>I4Y9L0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_33112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959187.1">
        <property type="nucleotide sequence ID" value="XM_006959125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9L0"/>
    <dbReference type="FunCoup" id="I4Y9L0">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9L0"/>
    <dbReference type="GeneID" id="18471623"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33112"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y9L0"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="236"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="52533" checksum="6AA2FDB1EE129DFA" modified="2012-09-05" version="1">MSTEQKQTVDYTKEVDALLSELRNDDDISQSIDRISVLEKKSRNAADLKSTTRLLVKAVELAIHQRNTTKLKEIVTSFSKKHGQMRTAIVELVRAASSISDEEQTEVYTLQGSEREDLIQSLRVVTEGKMFLEAERARLTYILAQVLLARNETRKARDVLAELSVETFGSLDRRQKTEYLLQQAFLNAQIGDWMQMKIVTNKINTKFFQEDNTQEHKLRYYEYLIRYAIHNDEYLNACRYYREVYDTEVIKSDSSRSKVVLENIVYFVLLAPFNHEQHDLLHRIFNDPVFNTPKLQYQYNLLKCFTTPELMRWAGLEALYGEMLKSTDVFSNRSTDGKGQSRFSEFHKRVLEHNIRVVYKYYTKITLKRLQSFLEVEERVVEEMLSNLVENGTIYAKIDRPAKVVTFTKPKKTEDVLNDFTNNIGRLLSLVETVNYQIEKEKAVQEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9L7</accession>
    <name>I4Y9L7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_29363</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959194.1">
        <property type="nucleotide sequence ID" value="XM_006959132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9L7"/>
    <dbReference type="STRING" id="671144.I4Y9L7"/>
    <dbReference type="GeneID" id="18471097"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29363"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288071_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9L7"/>
    <dbReference type="OMA" id="TITHHAQ"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="220"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="908"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM20659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="958" mass="107622" checksum="D88C70B97BD29D3F" modified="2012-09-05" version="1">MLGEFSINVRKITKHLNYLQGVQCARNQVSTLLACGLAITALFYPAFGVLLWSKSGRQSSFWNILEENTLTNSNDFKSLEFSSIWDLDDAFKVELANVAPVDMIVERIISPFDQTYDALLEEINALSISRCIRSSADKECLILSPNSEKYNQSSYTLTHFQSHPYAISTILFQPSEDHDQWWSNTLSSTGEWSVEKGLSTRKTISVKLRDNLTESDWSSVPYIFGIAYALFIIYVSISVSRLNQVHSRFGLAITGIVQLCVSTIMSISLLELCGWRLRLLPWTVVPFVIVVVGVENMLTITRAIVSTSISLPVPERVGQGMAKVGPVIGMTVLSDLTLLGIAGYVIPGTIREFCIFASVVSVIDYFLQSTFFITVLSVDIQRLELSDLIHQGLQPLPPKDGSIDSKNAGDNSHPLVVATKAVWKARSTRNASLLVLILVMGTLYYLTVPSKPLIPLEAFRNRPTEPSNVSSSLDNTIELLWSQLSTSNDPLNLRIQSPTFVTKFYSQYQMMDDQKYSRFSPRFRALFWILKIVVLPIGSSLIALYCLLLFLLKDKELHELQRSKLDAEQRKQEITQEKPRLHVEGYAQVVDRKADIAMVETSSKLLVYLTLLNDVVVHTNEQSYYLISSPKDKVTTVACNDNYVATGFSSGEIILWDLQSGYPELKELKRQVDVGHNNSVRSLKFVKKSKDYKESVPLRSPYMLSNEETEEALVAVFTKNWGLYWPTSTFEEFSMIGTTEDFENVSVISLENDRILWKRQMKTCQYIMSYDWPSRVVTLLTVVGEDVNSYDNFVDILKLNYQGSEKNLVVFQTPEGSVKLMEFGESTECEQIAELESLDKPILRTKLIQSAENDESVQQLFVVRNTQHKVYIDLVDIYFGDSCIDCGGTMSTTTTNVASTLVPSTANNATPMLLRNRSRKSGSGSGNGNIDGYPLANHGFSRRVSAADKRDDQPGKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N8</accession>
    <name>I4Y9N8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_69607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959213.1">
        <property type="nucleotide sequence ID" value="XM_006959151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N8"/>
    <dbReference type="FunCoup" id="I4Y9N8">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9N8"/>
    <dbReference type="GeneID" id="18475608"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69607"/>
    <dbReference type="eggNOG" id="KOG4639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086710_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y9N8"/>
    <dbReference type="OMA" id="MQNYLDK"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="149" mass="16963" checksum="0F9EBAB9D9CAF10E" modified="2012-09-05" version="1">MVRFKNRWIIAEIIFPDSPPFEDSPNTEKRLDGKQILQSIRRNIAHNFGDHGAGSVANSLSLKYHSAITRLCIFRIAREYKDMLHAALTLTTSLSEYDVCIRVLHVSGTIRKVQEAAIRYNREAILNTSSDTQEEDLDTSKNDIMAIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9R9</accession>
    <name>I4Y9R9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959244.1">
        <property type="nucleotide sequence ID" value="XM_006959182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9R9"/>
    <dbReference type="GeneID" id="18474988"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65131"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_1"/>
    <dbReference type="InParanoid" id="I4Y9R9"/>
    <dbReference type="OMA" id="QSDYPQK"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="331" mass="36527" checksum="B3874B7EC58B9BB1" modified="2012-09-05" version="1">MGLRPTKEVKINGETFEGKTVVCVGANAGIGLAKCDYLVENKVSRLIMACRSTDKAEKARQEVVKKIKNDSTTVEVWKIDLASLSSCREFASKWNANPDNKIDILYLNAGLIAPNASLITSEDGLEMTYACNVLGHLAVIEQLLPSLALSDDPRIIFTGSSGAKMSTLPDHPGSNKRTPLRDAWSIGSYVLNAFNIYTDTKLLLAMVVRELQESFKNHPDEKYRKIFVANYHPGFVKTTISNKDHYGLSSLLSIPVDFLTNRYAITPEVGARPGLYLGSASIEQLPGGEFWDENAEPASLTAQYDNEALRREYFERCIKDAGINPSTFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9S6</accession>
    <name>I4Y9S6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959251.1">
        <property type="nucleotide sequence ID" value="XM_006959189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9S6"/>
    <dbReference type="GeneID" id="18474180"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60812"/>
    <dbReference type="HOGENOM" id="CLU_957136_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9S6"/>
    <dbReference type="OMA" id="LANHVCA"/>
    <dbReference type="OrthoDB" id="10502162at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="299" mass="34529" checksum="78FFFFE735E8145C" modified="2012-09-05" version="1">MDVFDTSKDITDGQHTTINRDIPTSIYSLPVEILDKIICLEPQIAFTCRSLYHIGFRWLNNTVVGPRYELYGLCRLVYRENTYMLIDSFNRHLSNMTKIERHRFALRTLCVNMNNIRSGRRHILFNKLAANLKSFPNLTQVNIVLSSLYHILSIKHVVFDKITTLVLECRSVYLEGGEPQEVVDLLVNCTPNLRHFIIYAGNEFQESIQPLLHSLSQRMKEFEKLESGVVLYRKWSTVGFASTMLRLVEYERHGQIKRRESTLQPTAKVSQESTVIAAILERMSITKKSLIAGITIGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9T2</accession>
    <name>I4Y9T2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959256.1">
        <property type="nucleotide sequence ID" value="XM_006959194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9T2"/>
    <dbReference type="GeneID" id="18474182"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60814"/>
    <dbReference type="HOGENOM" id="CLU_1349824_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9T2"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="203" mass="22972" checksum="2E72D1FDE3381E13" modified="2012-09-05" version="1">MLLQAKIHLGEYTSSQPPSVDAAQVLVGEYRSVLELRSQKKDNECVEALCELAEVLVEVAKSGTSSWALLSEAQGLFKQALDLEVSLKTIGSVDPNSIANQIKILLAMSTVSVYRAELVGKSNANYQTLINNSQVYLKRGLEMTQPVHKPHPNWQVEDAKYEAIVRIIDERIKYHNESEESQRHLVDILRRNNVNVDVYRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAV9</accession>
    <name>I4YAV9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_19193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958734.1">
        <property type="nucleotide sequence ID" value="XM_006958672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAV9"/>
    <dbReference type="FunCoup" id="I4YAV9">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAV9"/>
    <dbReference type="GeneID" id="18470792"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19193"/>
    <dbReference type="eggNOG" id="KOG3013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034114_3_0_1"/>
    <dbReference type="InParanoid" id="I4YAV9"/>
    <dbReference type="OMA" id="GVNGFIW"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="71"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="302" mass="33332" checksum="A50C740A03D2D0BA" modified="2012-09-05" version="1">MDGVDIDDEDEDFSSSKLTAPGEIIASSSAYMHGHGTYVNDGNIISQMSGVVERVNKLVSVRPLKHKYLPQVGDLVIGRIVEVQAKRWKVNINAASDAVLMLSSINLPGGVQRRKLESDELQMRNFFTEGDLCVAEVQSFFHDGSVSLHTRSLKYGKLRNGTLATVQPNLMRRLKSHFYTLPVNVDLIIGLNGRIWVSKHMQVGQEVNLNEENEGFDSEGVYSNENDDIDSQTRESINRTAIVINILASHTVPLTDSLIATAYDVAVDLEGDNGIGYLTSNEEIQTELIHSALEVENGEMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAX5</accession>
    <name>I4YAX5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958794.1">
        <property type="nucleotide sequence ID" value="XM_006958732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAX5"/>
    <dbReference type="STRING" id="671144.I4YAX5"/>
    <dbReference type="GeneID" id="18474041"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60585"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAX5"/>
    <dbReference type="OMA" id="TLWAHFY"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="608" mass="69974" checksum="4681F076E483E2C4" modified="2012-09-05" version="1">MPQDSGEQPQQEQQSNGIWHYAKRALLIWVVSRAVLGPNGLISKYTGMDKLSPQPQGPMPVSTPEDATNSVVPVQVTNLWEKDTEMDLFIKLSTSNNPYLALETDDGLPEIHWTNINYGDWNLDRTASFDIELPESVKNNGTLWADFFLSKKDAPINQRDPSYDPLAVAHSRKLLTRFHPKKKARKEKNLLSDDSSDGEDDEEDKETPELIVPYWHSNLTVSIIQDTGINIPYTQTQPAARKFIALDPLNRRKEGVKPETGYHYPIIYPNDFWLLRNQFVELNETTDVVPLHISLSSLSFFKFNIYANIHAGMEEQAQTQGTGGELDEFKRMLVETNPYFLALTALVTLLHTVFEFLAFKNDVSHWKGENHDMVGVSLRSIIANVIVQIIILLYLIDNNENASWTIIGGQAIGLVIEAWKITKAINFKILPPAPNSWLPFNFQFEDRKELSEDEKKTREYDALAFRYVSWVMVPVLIAYTIYSLLYETHRGWYSFVISTLTSFVYAFGFVQLVPQLILNYKLKSVAHMPGRAMVYKTLSTVIDDLFSFIIKMPLLHRLSCFRDDVVFLIYLYQRWIYSVDPNRLNEYGQATDEKIEQFEKEQESKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY6</accession>
    <name>I4YAY6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_19345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958737.1">
        <property type="nucleotide sequence ID" value="XM_006958675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY6"/>
    <dbReference type="STRING" id="671144.I4YAY6"/>
    <dbReference type="GeneID" id="18470795"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19345"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020840_9_0_1"/>
    <dbReference type="InParanoid" id="I4YAY6"/>
    <dbReference type="OMA" id="EYECRCG"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16276" checksum="CE5A3EB5D93772F5" modified="2012-09-05" version="1" fragment="single">RTRKKELRFAKSSIHSWGLYSCQVIPKGEMVIEYVGEVVRQQVADRREKAYEKQGIGSSYLFKIDDDNIVDATMKGSVARLINHCCQPNCTAKIITILGEKKIIIYAKTEISPGDEITYDYHFPIEDEKIPCLCGVEGCRGSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB10</accession>
    <name>I4YB10_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958826.1">
        <property type="nucleotide sequence ID" value="XM_006958764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB10"/>
    <dbReference type="FunCoup" id="I4YB10">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB10"/>
    <dbReference type="GeneID" id="18474049"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60601"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="InParanoid" id="I4YB10"/>
    <dbReference type="OMA" id="KKSLVWI"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="101"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="34492" checksum="4CB7493293C9B3E3" modified="2012-09-05" version="1">MITKILGLISIPLIVLPKSRYSIKMKLVIHTLLYTTGLAVNSIIGLLCGLIAYPLGTQYRQQLSHFVARSFYYTFTPVLGWNFVVKDEEKLLEYSNNKKSSIIISNHQTMLDILFLSRIFPNYTTMMAKQELKKIPLLGWWMSLSKSVFINRSDRTGAISSFNRIANEIKDNGINVWIFPEGTRSSTKEPSLLPFKKGAFHLAIQAQIPLVPVLCENYYHLANFDKKDMKFERGTVQIKVLDPIPTKGLTSQDVQQLIDYTHSYMLYHLKLLSAESSNSEPPAPFTLQPPSRSDDDDLVVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB29</accession>
    <name>I4YB29_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958844.1">
        <property type="nucleotide sequence ID" value="XM_006958782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB29"/>
    <dbReference type="FunCoup" id="I4YB29">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB29"/>
    <dbReference type="GeneID" id="18474057"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60613"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB29"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="31469" checksum="D2944B55DA35C96C" modified="2012-09-05" version="1">MGKYALLVSGPAGAGKSTLCSTLIQHASAKNRNIHLFNLDPAAENFDIEPEIDVRDLISLEDVMDELNLGPNGGLIYCFEYLMNNLDWLEEQLGEYEDDYLIIDCPGQIELYTHFPLMQILIENLTKLNIKVAAAYLLESQFMDDISKYFAGVLSATSAMINLEVPHINVMTKMDLIGDDNVVTRGRKKKDLERFLEPDPDLIDQINTTTNEKFHRLNKSIVDLIADHNLIQFIPLDITNEDTVENLLSHIDNSIQYGEDEEPNEPADLDDGDFDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL6</accession>
    <name>I4YBL6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958706.1">
        <property type="nucleotide sequence ID" value="XM_006958644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL6"/>
    <dbReference type="FunCoup" id="I4YBL6">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBL6"/>
    <dbReference type="GeneID" id="18474015"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60543"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBL6"/>
    <dbReference type="OMA" id="NISEFMH"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="166"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="35541" checksum="159D74DB16862577" modified="2012-09-05" version="1">MFIGLIGLDSETIHITKKYLVEERGFTAIDLKGDLDDLPQEVVDMKMLTFGDLMDYVTSHWQDNFVTATLPYGNTECLDLFMRRPFTLLVGLEARIERTIKSCVNRFADLFDGMDISTMFDLGYGIIRPTMSKAQLNIYNPYETEEEFLELLRTINIEDTERIRPNWDTYFMELADLASQRSNCMKRRVGAVLTEEKRVVATGYNGTPRGLKNCTEGGCTRCNSGVEQGFAECLCLHAEENALLEAGRSRIGSNAVLYCDTCPCLGCAIKIIQTGIKEVVYNQAYRVDDKTYTLFKSSGVILRKYSNDHKIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBW7</accession>
    <name>I4YBW7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Initiator tRNA phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_64409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958489.1">
        <property type="nucleotide sequence ID" value="XM_006958427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBW7"/>
    <dbReference type="FunCoup" id="I4YBW7">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBW7"/>
    <dbReference type="GeneID" id="18474924"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64409"/>
    <dbReference type="eggNOG" id="KOG2634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="InParanoid" id="I4YBW7"/>
    <dbReference type="OMA" id="HANPSEC"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697803" evidence="1">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="2">
        <location>
            <begin position="326"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="434" mass="48829" checksum="303EE921900BE5B0" modified="2012-09-05" version="1">MTVTIDCILSLCTFFSLFTPQFPADEDNSDSQFVDSLGRHYSDYSVVAANQRCGVWYINPKLENYRPDIYAYFKSTDGHTNAWSFSLRRPNLHLIEHILECKGLIIVDSTRRGKRFPDALSKTIPIWCAVVSSAVLGIPAEDLLYTPPNAISESEKQAIKDGLPTWREWLVNSALQLNKRLDKPLRPIFIHPETQFLPDFSTSTLDFYPILCVSASRYIPDQIERRSWGEYVQGSGDDHELWAKGLTPEAFWENQDELLSCSSEMLNECIVEIMSERQTHSTKDVGSANRTFLKGAIYPSSSEAGVPEDDAFVALTPNPPSRSKNTMHITLPKSSKQAQKEFLAKLPSIVDFIERELNKGGHVAICDANGGTDLASVVCVAIATLFFDENGEKISRNTNITKTAINMRLQWLINVYPSSNPSRVSLKRLNDYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC20</accession>
    <name>I4YC20_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_69075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958540.1">
        <property type="nucleotide sequence ID" value="XM_006958478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC20"/>
    <dbReference type="FunCoup" id="I4YC20">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC20"/>
    <dbReference type="GeneID" id="18475520"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69075"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="InParanoid" id="I4YC20"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="57"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="431" mass="47516" checksum="3DF5BC0DB9808E71" modified="2012-09-05" version="1">MNDQRQYFVLGFTSIVALSTLYAVYKINKEKKRYTRFADDEGIVVEDNRQISEGLPDLIGKTPLIRIASLSDALGVDILGKCEFMNPGGSVKDRVALKIIQDAEERGELIPHTNSCIYEGTVGSTGISIAMVARAKGYKAAIIMPDDVSAEKCDILLKLGAHVEKVRPASIVDKKQFVNLAEIRASQYTEGMANEEPGNASTPTIENANDIMLTKEKKKKGKAVGFFADQFERQSNWKAHYDGTAKEIWTQTDCGQFDAFVSGAGTGGTISGCATYFKERNEDIKIVLSDPEGSGLYNKVKYGVMFASQEKEGTKRRHQVDSIVEGIGINRLTANFDKGYEYIDDAYRVSDEEAVAMSRYVMINDGLFLGSSSACNLVAAVRLAKTIKKGSSIVTILCDSGTRHLSRFWDDKRLSELDIKVKQDINDILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC37</accession>
    <name>I4YC37_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_60479</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958554.1">
        <property type="nucleotide sequence ID" value="XM_006958492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC37"/>
    <dbReference type="FunCoup" id="I4YC37">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC37"/>
    <dbReference type="GeneID" id="18473973"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60479"/>
    <dbReference type="eggNOG" id="KOG0851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012393_2_0_1"/>
    <dbReference type="InParanoid" id="I4YC37"/>
    <dbReference type="OMA" id="DQCDAFY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="175"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="283"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="445"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="599" mass="67494" checksum="F0B62E815065B1AA" modified="2012-09-05" version="1">MPELTKDAIEAINSENPAGLLAGQNPVVQVLQVKKATASSDKAPDRYRMVLSDGKYYMQAMLGTQLNSYPEQELLIKNSVIKLLNYAVNVVQNRLLVIALQIDIVETGPLEKIGSPQNFDQTKSQQPQQQTEQQPQQQDIKPDVKPDIKPNFSKGPSSQAPVYPIEGLSPYQNKWTIKARVTQKSDIKFWSNQRGEGKLFSVNLMDETGEIRATGFNESVDEFYNMLEEGKVFFITKARVQIAKKQFSNLQNEYEIAFDKTTHIEPCYDTSDVPDVKYSFTELQNLENLEPNAITDVLGVVTTAEEPSQIISKSTQKPYTKRELNIVDRSQQSVRLTLWGKLAENFDQVNEPVIAFKGVKVSDFGGRSLSMVGASTLFVNPDIPEAHSLRGWYDQQGKNEQFSTFNNSSSTVKPEPGTVKPNEIKTLEQVKQSQLGLNDSGKPDYWTGKATVTYIKKENITYPSCPNDMKKLTQDMNDKWRCEKCESSFDAPEYRYIITCNATDHTGQIWLSGFNDFGLELFKMPANDLQAMVNNGDDASFEAAVKNALGSSFNFNCRAKQDTFNDNVRVRHQINRASTVNYKSEINRLCETISKLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG1</accession>
    <name>I4YCG1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF572-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_9064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958231.1">
        <property type="nucleotide sequence ID" value="XM_006958169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG1"/>
    <dbReference type="FunCoup" id="I4YCG1">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCG1"/>
    <dbReference type="GeneID" id="18475844"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9064"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053603_2_3_1"/>
    <dbReference type="InParanoid" id="I4YCG1"/>
    <dbReference type="OMA" id="ENCDYQN"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="171" mass="20242" checksum="E985ED0D7253FF9A" modified="2012-09-05" version="1" fragment="single">MADRKVLNKYYPPDYDPSIIPRMKRGKERQQQVRLMTPYSMRCTKCGEFIYRGKKFNARKEEAKGEDYYGIKVFRFYIKCPLCSSEITFKTDPQNTDYAAEHGATRNYDAWQETEPKKDLSKIAAEGDEPEEEEQDPMKQLEQRTLESKREMEIMDALSDIRTRNAKNERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCL5</accession>
    <name>I4YCL5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_38317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958391.1">
        <property type="nucleotide sequence ID" value="XM_006958329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCL5"/>
    <dbReference type="GeneID" id="18472057"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38317"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765491_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCL5"/>
    <dbReference type="OMA" id="NRGVQLC"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697985" description="DUF803-domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40228" checksum="74F1B58F89E28223" modified="2012-09-05" version="1">MNLAVVILLVVACAALQSFGLTVQRKSHIENYSSQWIVGFTIYLVFNILGTIIQLASLPLIVLAPLGAISLIPNIVFARLLLKDKRRELVQGIILICIGATLIAYHSDLSPDHLSYHQLMKLFSKTNNEVYLALQVIVIGATISIGHLWEHKRDTSVAEASPFIESAKSHKRNGPAVLFASSSGILSGFCLLLAKGGIDVLSKTIIKNGKWKVLLHWQIWLLIAVLVVSAVLQLWYLNRALKLADPSLICPLAFCFYNVSSILNGLVFFKQYTHTSKTDLLTITAGTTVLLTGVWIISLNESLKENTGVESTDNSDTITEQHSPPISPTIQQGFSIGISANSPNFTTQHQSRQNSLLGTITSLFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCS1</accession>
    <name>I4YCS1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_68691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958071.1">
        <property type="nucleotide sequence ID" value="XM_006958009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCS1"/>
    <dbReference type="STRING" id="671144.I4YCS1"/>
    <dbReference type="GeneID" id="18475453"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68691"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511115_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCS1"/>
    <dbReference type="OMA" id="VHKRECE"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="59"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60225" checksum="992783F2867733C6" modified="2012-09-05" version="1">MSFSDLAAKREARLKTQQKRQEAENVDARPTELSTEVPTEASTSSHRLEEEDLIKVLNVDVEIRQTKDKGRGLFARRDLKPGHTVLSTIPTVIALDKQHISQFCSYTAQSEYGGLFASELGTMKKLARCSLCKTIFYASKEAQKSDWPIHKNECLCLRSLGSSSIPQDSVRALARFVWMKDHKRTLGDNEWGQSVEDMYDAYDNYTEEQKIGLGNKAKEFFDFFTQGGKDREAMSRYNLSISYIMRMLCKIQTNGFALSGSDFMEIGTAICPLAACINHNQEYNSTVLFTQEDNRLSVVAFKGIEKGDEITTTYVDGAEPWDAQRNQLLKQYLFDIGPGPDTDSKVDAFDQHEGQKVALKLAKPLQSAEKWMTSDPIKAFNQLQPHYESVVKTYPPHSYHRLRYLRSCFTAMTAISYMDDMPSWAPSMAVELAKATLESTKAILPYGHPVRGLMLVELSKQMLANRNEEKGTSEQTVVKKLTNCITITEEALAEVKIGYGKGSYFSRGLEKQLQDIKLEIHFRNMAQMSISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDA5</accession>
    <name>I4YDA5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957759.1">
        <property type="nucleotide sequence ID" value="XM_006957697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDA5"/>
    <dbReference type="STRING" id="671144.I4YDA5"/>
    <dbReference type="GeneID" id="18475401"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68447"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115073_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDA5"/>
    <dbReference type="OMA" id="TQITHNS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="20037" checksum="25024D2C3888A7B4" modified="2012-09-05" version="1">MKYMTEFVAYQHPGSMSEDFLILDELLNYTKELNRQAGQPSPGAVRKTNKGPKGVKKKPWTLEETFWLEHYLQLYYFTLNGQPPWAYIRDRHGKNGTIDQTLASRSHIDLQDKARIMSGKLWREGKEIPPWLLSAKPPKRILDKMRPIRGEWPKKHIKSIESTDSPDSTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDD1</accession>
    <name>I4YDD1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957783.1">
        <property type="nucleotide sequence ID" value="XM_006957721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDD1"/>
    <dbReference type="GeneID" id="18472879"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57095"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687365_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDD1"/>
    <dbReference type="OMA" id="DIFIWEE"/>
    <dbReference type="OrthoDB" id="3361767at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43372" checksum="F0D505E63882A9F8" modified="2012-09-05" version="1">MPTYNGQIINNLDAVILLKAVQADKLKVYRRRLTSSERNSIKTGDVFIWEECQGMQRWTDGKRWGPSRVQGGFLWYKEIEVEEKASSLVKQTYSLPQTLSNSLPDPKLHLVCYTNSFNKAIRPSQDSELSMFKDKIDYTTPSVLTSPSVPDKRPEPINIVNPSNRSFSPPPTPPHSFSNAAFTDPFHGTVITPPVSATRADFNQVSLSARQTNRRASHPNTNNASAIQAGAYAATLASRSSIRRGSSPYPSPRRNTSIFESRPSFSQRKRSNFGVPPTINTAQGANVPPPMTSAPATYTSQTIPTTAVQQRPSSSHSQTTADYVHSNKYMPQRTAYQPLQQQPAYAQRASLPPITASRNNSTSSITHATSIMSLCDEDKRQLDSFKFTGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDG1</accession>
    <name>I4YDG1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957812.1">
        <property type="nucleotide sequence ID" value="XM_006957750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDG1"/>
    <dbReference type="STRING" id="671144.I4YDG1"/>
    <dbReference type="GeneID" id="18473756"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60125"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_11_1"/>
    <dbReference type="InParanoid" id="I4YDG1"/>
    <dbReference type="OMA" id="CHNCIVW"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="25728" checksum="352A498068677854" modified="2012-09-05" version="1">MDGTTSLISLSEQKVAASTSHPGIWKTAIHPITLGHYVTSPAKLDSHLNVHSANNLHETDDDPEFGSYLGTYEMGRPAFIMSLEFSPDGRWLVAGAQSGQSYVFDASSGSLVRVHSAHSKPIRSISFSPDSSILYTSSDDKLISAVDLRASTSSGAVFSLSNVHDSSVTAISAAPDSKLLASGSTDHSIRLFDVGQRASVAKIAQEEEVWSLSWRPLGVSGQSGSGFVSSGDSGVVRWWKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDG3</accession>
    <name>I4YDG3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957814.1">
        <property type="nucleotide sequence ID" value="XM_006957752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDG3"/>
    <dbReference type="STRING" id="671144.I4YDG3"/>
    <dbReference type="GeneID" id="18473757"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60126"/>
    <dbReference type="eggNOG" id="KOG1398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016206_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDG3"/>
    <dbReference type="OMA" id="RMDLALY"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46581" checksum="0BB4EBD69F4BAEF9" modified="2012-09-05" version="1">MRLTLNIILALVSLFKTRKLTGKLLKRALFSAEPLRFGSQFAVFVWLWRFIHHALRIMDGKHKRWHAWVAGAISSLGSLIETRSNRLALGQQLTVRGLHGMYRSCKARNWISIPYGEFVIFGLACGQIMYAWIMSPDTIPKAYNDWIQQASKVPPEAIPMHRQLVRTGTYNSQSLLTSLAQRKPTPKNKLRLLKLLQDLQNGENRLLPYIPPAVLNPWVEGILPMAIERFYMIFLDILPVYASLHFIPALTLKRKQFSEDPGEAVLRTTLSSFRSSAFLATFVVIYHSWFSSKHALYRLHKDNLPSWLSNFLISKESLWVGGFLTCASLAVEEKKRRSELAMYVLPKAMESAWTTARRKKWLPHIPLGPELLVMFGTASLMQAYTHEPQVLSGLVHTLIYQFIGNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDK6</accession>
    <name>I4YDK6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_17645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957743.1">
        <property type="nucleotide sequence ID" value="XM_006957681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDK6"/>
    <dbReference type="GeneID" id="18470736"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17645"/>
    <dbReference type="HOGENOM" id="CLU_166246_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDK6"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="55" mass="6261" checksum="B0A7DC6E03BF28BE" modified="2012-09-05" version="1" fragment="single">DPAVKQIILNLNDKSKFIVQDLDLQHILVSPDSVQSIKYELENEVCRTVHRTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDK9</accession>
    <name>I4YDK9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_45169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957855.1">
        <property type="nucleotide sequence ID" value="XM_006957793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDK9"/>
    <dbReference type="STRING" id="671144.I4YDK9"/>
    <dbReference type="GeneID" id="18472354"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45169"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005415_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDK9"/>
    <dbReference type="OMA" id="NKWPMFY"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="199"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="472"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="73801" checksum="CCB72B2AC9441070" modified="2012-09-05" version="1">MRSIRKLSDEARSGIRSAYIITSVQQLTRELLDNAIEADSTQIQVLISLDDWSIKLTDNGIGIQKDSLAELGRSHMSSKKGSKGETLASISQLASLKITTRHASSLSTHTLIARAGHSVYFGLSLDGNRSSRGTVVTVTDIFANIPVRRKSLNKAREIHGIKSDMQSLALVHPEIAFELRNSQQILIQLPPSHDTVSRFREIFGYALAEHVEEINYHGSDHVVDGFMSLECAHSRAYQYIFVNSHLIVAGDLHSVVSTTFAESSFGVMANEPASMESNASRRHAQRYPVFLLHIHIPSSILESTYDRHHRMFYIDNQASLSNTLKQLVIDFLVKYSFISPVAESYTSASNPRHSQATTLSKSVTANKRAVSDSAVSTQQSVRSVTSPQPSRDTKKAKNENASRTSQQRRTIDVHGINSTRTSKSDWLTNVLNKWNNPTYRLLKSTTATSVDSSESRRESFKLTKADIENARVVGQVDDKFIMAVVTTKNALVAFDQHAVDERIRVERYLEALIRRDDIVLVDPPIGTLLTYEEMRTLGTNVETVEQWGFLIDIDIKPSQEHYGQVFVKTLPGVMHDRLIREPKLVQDIIQEAVARGMNESTTLNWHVMVGLCPPTLLSLVNSKACRNSIKFGDTLSMRDCEMLLQSLSHTKNPYQCAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ2</accession>
    <name>I4YDQ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_37589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957897.1">
        <property type="nucleotide sequence ID" value="XM_006957835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ2"/>
    <dbReference type="STRING" id="671144.I4YDQ2"/>
    <dbReference type="GeneID" id="18472024"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37589"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="I4YDQ2"/>
    <dbReference type="OMA" id="CKGHDTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="7"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="41213" checksum="ADA5A56B0FCABB4D" modified="2012-09-05" version="1">MYKLKNTLAGHKRSVTRAKFSNSGNYLASASADKTVKIWEIENGYLYESFEEHQDGVNDICWSSNDKCVASASDDRSIILWSIEGNRAMKVLKGHTNYVFCVSYNPQCNLLASGSFDETVRIWDALRGKCLRTISAHSDPVLSIDFSSDGSYIASCSMDGLIRIWDVWTGQCLKTLVDESNKQATFLKFSPNSQYLLSASLDQLVKLWEYSNKDRPIRTYSGHDNSIYAQSIDYGMIDGKRVVLAGSEDGKIYVWDLQTMKVLHSFTAHKDAVINIHSHSHLPRICSCSLEKDLTIKIWEYTDTPAIEDMHIEATPSEQANEAPKENIEVAKESTEIPSKESTEAQEDTTITEHTNVTTTDRMDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDV0</accession>
    <name>I4YDV0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_51122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957942.1">
        <property type="nucleotide sequence ID" value="XM_006957880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDV0"/>
    <dbReference type="STRING" id="671144.I4YDV0"/>
    <dbReference type="GeneID" id="18472547"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51122"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_1_1"/>
    <dbReference type="InParanoid" id="I4YDV0"/>
    <dbReference type="OMA" id="QIIFIRM"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="201"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="375" mass="41184" checksum="E7DA1E079390B0B1" modified="2012-09-05" version="1">MAADEELSVSSSTTARSFEETEIKQQSFISRNAGLLMIALAQLFFSSMSLAVKVLADVDPPVSALELVVVRMGLTGVLSQMYILVHNIFSDDKIPNPILGPLEVRGLLFARGFVGFASITALYHSLKYLDLSDVSALQFLLPTISGFSGMLFLKEPYLPIERYSSIVSLLGVILIARPPFIFGHEGAQINVDLGAIGIRTLAVCAVIVSVFGASLAYVTTRAIGKRAHPMHVILAFSWCSVIFGTLMMKIQGEQFVLPKSSKWTALLIAVGTFGFLGQILLTLGLRREKVGRASLGMYLQIVFALIFEKVFFNTTPEMLSVVGASLIIATSTIVAMNKNKNKTEEKENDERETLLRDERQRFASVDYGTLEQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW9</accession>
    <name>I4YDW9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957960.1">
        <property type="nucleotide sequence ID" value="XM_006957898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW9"/>
    <dbReference type="STRING" id="671144.I4YDW9"/>
    <dbReference type="GeneID" id="18471459"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32292"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="I4YDW9"/>
    <dbReference type="OMA" id="GFGQEEQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="39"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="316"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="648"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1226" mass="133860" checksum="AF290AD3CE5CB9CD" modified="2012-09-05" version="1">MTTFTQKSLEYRANPSDPGLTQEFNAAADDLNDDVSMNCIYLVVIGVAMFIGTYTYTVIFTYTSENISRRVREMYLRAVLRQDVAFFDKIGAGEVATRIETDTHLIQTGVSEKVGTAAMYIATFITGFIIAFARQARLAGVMFIIVPCIAVLGGLLTTFTSKYQTRSLDNIAASGNLAEEVISTIRTAKAFGSQLLLGNLYDEELHKARKTGYRAASVNALGLTVVFFIIYCSYALAFAWGVTLILKGEADSGQIVSVLMSILIGAFSLAMMNPELQAIGKGRGAAAKIYETIERVPFIDSASDEGLKPATVDGNISFTDANFAYPARPEVQVMKNFTATFPKGQLTALVGASGSGKSTSISLIERFYDPLSGSVKLDGNDLKDINVKWLRSKIGLVGQEPILFNDTVRANVEHGLIGTEMEHWPDEQRLELVINACKVANADGFINTLPEKYDNSVGERGMLLSGGQKQRVAIARAIVSDPPILLLDEATAALDSASESIVQKALDKAAKNRTTIAIAHRLSTIKNANQIIVMGGGEILEVGDHNSLTANPNGAYSTLVAAQSLAQAKSDEAAQTKSGTVEKEEAEEEIDQEDVIPIDRVKSGRSITSQVLEKRREEKGEYKEKNYSFFQVIIELVKLNKDGRWMYAIGAAAAFVTGSVYPIFSILFGKTLQDISLSPEDPNYHSQMRHNGDRDALWFFVIAIGSAIAIYIQSLMMHSAGEKLTYVLRHKSFKKLLRSDIEYFDQKENSTGVLTSQLADNSQKVQGLAGVTAGTIIQSCSTLIVGIAIGIGYNWKLGLIGTACIPFTLSAGITRLRIVVLKDKRNKKAYEDSAQLACEAAGSIRTVASLTREDQLSQYYHDALEIPYNHSVKSAIYSSALYALGQCLTFWVLGLIFWYGTQQLTKLEVDIQGFYVTLMAVIFSSIQAGNVFAFVPDISSARGGAARVLNLLRMKPEIEVEYDNQDGKHLDTVEGHITFEDVHFRYPTRSDVPVLRSLDLEIKPGSYVALVGPSGCGKSTTIQLIERFYDPAYGSVKLDGHEVRDLNLNNLRSHMALVSQEPTLYAGTVKYNILMGAVKPHEEVSQQELEDACADANILDFIRDLPDGFETQVGGKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDQTSEAVVQAALDKVASGRTTIAIAHRLSTIQKADRIYVFKDGKVSQAGTHKELIEQKDGLYAELVALQTLSKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDX4</accession>
    <name>I4YDX4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_68621</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957964.1">
        <property type="nucleotide sequence ID" value="XM_006957902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDX4"/>
    <dbReference type="FunCoup" id="I4YDX4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDX4"/>
    <dbReference type="GeneID" id="18475440"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68621"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="I4YDX4"/>
    <dbReference type="OMA" id="RGKNAMD"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="41"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="241"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM22166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="419" mass="46168" checksum="8B28194D16DFF246" modified="2012-09-05" version="1">MTVSDSSIKPLLKFDDLQVEESLVKPLKNFEKPTPIQSITWPCLLQGKDTIGIAETGSGKTLAFAIPGLSRHVLSDASNKTASILVIAPTRELAVQTYDNIDKLNITQSICLYGGVSKDEQKRTIKKNKPRVIVGTPGRLLDLANDGGVDFSNVKYLVLDEADRMLDQGFEKDITAIISKTPKERQTAMFSATWPQSVRALAATFMKDPVRVTVGSEELTANKRVDQVIETLDNGRMKEQRLNAHLKSIRKDMGNARVLVFALYKKEASRIENTLRRGGHAVGSIHGDLSQQQRMKALADFKDGSVPLLVATDVAARGLDIPNVEVVINVTFPLTIEDYVHRIGRTGRGGAYGKSITFFTDDDKSHAGELMKVLREGGYEIPEGLKKYPAVIKKKEHGAYGAFYKDIGEAPKPKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDX7</accession>
    <name>I4YDX7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957967.1">
        <property type="nucleotide sequence ID" value="XM_006957905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDX7"/>
    <dbReference type="GeneID" id="18473803"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60192"/>
    <dbReference type="eggNOG" id="ENOG502QPKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDX7"/>
    <dbReference type="OMA" id="GGNKEYG"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="47024" checksum="4E5DFA12EF68DA41" modified="2012-09-05" version="1">MATIQSCKATSCCSTNTPKACNQEDEKAGLSDCPLFEDDCLDCDFCDGLNNFDEKANNTCATDPFKSLSIFDKLLGPLVLIAMILGVVIGVYAKDGVKTHLIESAQWEGVSVPILVGLLLMIWPALSKVNWEKLVDLSRELKLWIHVGMSIIINWIISPLMMLGIAWATLPDAEMERYRKGVLLVGVSRCIAMVIIWTTIADGDVNYCGYLMVINSLLQIVLFSPYSLLFVNILGGNSGGPQLHLDYESTARSVGIYLGIPLAAGIITRFALLKYSSVKFRGWFYEVAGKIGLIGLLYTIIVLFASQGSNITKNIGKVFRTIVPLLLYFIIVWFATFLGFWKLDRSHRYRDLAGGGYERAVTQAFTAGSNNFELAIAVATAAFGPDSPETIAATLGPLIEVPVLLLLSYVALFLRAKLFKGSSSIKLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED9</accession>
    <name>I4YED9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_44729</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957586.1">
        <property type="nucleotide sequence ID" value="XM_006957524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED9"/>
    <dbReference type="FunCoup" id="I4YED9">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YED9"/>
    <dbReference type="GeneID" id="18472341"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44729"/>
    <dbReference type="eggNOG" id="KOG3494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171977_3_0_1"/>
    <dbReference type="InParanoid" id="I4YED9"/>
    <dbReference type="OMA" id="ANAGMQW"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="66" mass="7385" checksum="B8499ACD9E57CBE4" modified="2012-09-05" version="1">MSFAQTLNNTLFKRNSTYVATIFVGTFAFGVGFDVLTTSIWDKHNAGKQWPELRAKILAKGESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEE2</accession>
    <name>I4YEE2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_44740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957589.1">
        <property type="nucleotide sequence ID" value="XM_006957527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEE2"/>
    <dbReference type="FunCoup" id="I4YEE2">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEE2"/>
    <dbReference type="GeneID" id="18472342"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44740"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_2_2_1"/>
    <dbReference type="InParanoid" id="I4YEE2"/>
    <dbReference type="OMA" id="WILISAR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="20335" checksum="B00EE17ED64FC565" modified="2012-09-05" version="1">MFKRFLNTTARISQESHFEQITRNGYSHNPSAIPPSSDPLLGYLTNLIMKDGKKARAQSHLKKTLTEIKTLTANTTEPVSLVRNAITMAAPSFRLSSSKKNNKVLHTPLALTERQRIRLAFQALIKASDKRNEKFLHQRLAREVLAILEQQSDVLKRKEEIHKAGAINRANLVQAMLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEN9</accession>
    <name>I4YEN9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC189-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957674.1">
        <property type="nucleotide sequence ID" value="XM_006957612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEN9"/>
    <dbReference type="FunCoup" id="I4YEN9">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEN9"/>
    <dbReference type="GeneID" id="18475386"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68386"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051061_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEN9"/>
    <dbReference type="OMA" id="HWIIVTH"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="33346" checksum="099AB18735CB80E8" modified="2012-09-05" version="1">MSSPIKKKSKQSQQPVAHTSIYKSQSDQNVDEHAQLPTDNLAELSLGQRLKASSKKAEELDGEEDTETPALPVNSLATLLTQSLNSNDTNLLESCLGQTDASIIRNTVDRLPSQLAIPLLHQCTTRLAKPGKAGPQRAKGLLEWSRAVLTIHTAYLLSMPNVTEKLLGLHSALSQRISSHEKLMGLSGRLDVVLSQIALQRSIQEERRSKEQNKKSNNAVTYIEGDSDEEDNVEYDNDDAEAIEDVELGNGEDESDSESGEEVEDDEEIDNSLDGDDSDRNAMVEDEAIEEDDDSDDDDEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEQ2</accession>
    <name>I4YEQ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957685.1">
        <property type="nucleotide sequence ID" value="XM_006957623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEQ2"/>
    <dbReference type="STRING" id="671144.I4YEQ2"/>
    <dbReference type="GeneID" id="18475390"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68398"/>
    <dbReference type="eggNOG" id="ENOG502SC1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555742_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEQ2"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="114"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="413" mass="46164" checksum="D1CD53C7643CA819" modified="2012-09-05" version="1">MNISRSYNKENWLPTPEPSSDNDKYAAGLQKPALPALPPRPALPKVAHMNHAIATNPTIFATPPPSSPLRSQSPAELASSPPAKTFATLAREESNESVESAHTTDLFASPTRTLVLGRGRKNWTNAQKRLEIPLSPKIDRIRHYVFPSSFSHISRTHLSIYPNVKQNSFNIRILGQNGIKLNGRHFSKGTRLRVSKNKDDGLAISCLMPHKLAKKPRYKLVMKSRAKQVNLTIGDTKLALHWSDLVHHKSILSDCESDESETEMPTTPSKRKRRSTPSDITEEVSQEHLGLIAQTLALNVPTSLTPIKEIASCLLNCNPSLEKEASLEEWEDIVQRTLLNAPGQMFGCVERSGRDAANRPLPNLYYYQPSNDPDRIRAQSLAPLTRVPRQASRAGQAKQVFWKPVSIRPKKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW1</accession>
    <name>I4YEW1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_63145</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957176.1">
        <property type="nucleotide sequence ID" value="XM_006957114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW1"/>
    <dbReference type="STRING" id="671144.I4YEW1"/>
    <dbReference type="GeneID" id="18474814"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63145"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="I4YEW1"/>
    <dbReference type="OMA" id="HMVVPLL"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="508" mass="57747" checksum="63D30D7CA2E093C2" modified="2012-09-05" version="1">MAFDYTLNWTYAVGAVTLLFLVVCRPRVKHLPPGPRKLPIIGNAHQLIGKNLVQYLDGLAKQYGPLVHLQILNQSIIVVNDYQTAKDLFETKHKVYSERPSFWMASQLMQKGYMMPFISNNERFKKVRKLLVSELRPVKVASAFHKIQTFEVQRLVKTLVDTPASFRDNIQRSITSIIMSGCYDLPIRSEESAKDARKVAQLAEEIVYAMEAGNNIIDALPVLRHVPRLPDKVYAEDYYQRADGIYKGLMDSVKDRLRQGQKLEGIASRLLQSTEDQDVDYQEQYWALGAFYLAGSDTQSVFSSIMMMALALHPDILKTAQEEVDRVIGPDRLPTHEDELNLPYLKALIKEVFRWRPVGPIGIPHASGSDDLHNGYHIPKGSIVIGNILSMSMDERLFKDPHLLNPQRYIDDPELPVFVFGFGRRICPGQHLAEATLLLEFSTIIWTLNIEQARDEKGKPIPINIDHATGFLPGGLMKPHPFEIRITPRSLARVKLLDETFENLNHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF19</accession>
    <name>I4YF19_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957231.1">
        <property type="nucleotide sequence ID" value="XM_006957169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF19"/>
    <dbReference type="GeneID" id="18473574"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59830"/>
    <dbReference type="HOGENOM" id="CLU_1442130_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF19"/>
    <dbReference type="OMA" id="SQCVEER"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="189" mass="21628" checksum="1865135E5FD51AA3" modified="2012-09-05" version="1">MKNLVKLYPTGTLDPTIFYCQMLDITVKFEELNGNLDISKLSVISGGMWTIFTIKVGVYDIENARIAGKFIFSDIESHIPQIKCNNADRDPETKSITSISNEKGPKWVYVANMFREEQGSKCVAYFRDGSRSSKRSPYIVLDSHLNSVDNVDLLIFCTLLLAKQLKKRKQSSQKYKYLVKKYGRFSNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF29</accession>
    <name>I4YF29_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="15">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_59836</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="15"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957241.1">
        <property type="nucleotide sequence ID" value="XM_006957179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF29"/>
    <dbReference type="STRING" id="671144.I4YF29"/>
    <dbReference type="GeneID" id="18473578"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59836"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_2_1"/>
    <dbReference type="InParanoid" id="I4YF29"/>
    <dbReference type="OMA" id="VIFNCIQ"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM22571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="17126" checksum="9FCD7C99285195DD" modified="2012-09-05" version="1">MNTTTALISLGLPQHYGWVGLAASSTFFLNVFQMLNVVKARKRANIQYPQLYADKAQIDANKDAYIFNCAQRAHMNTTESASYFLFTLLWSGLKYPQTAAALGFAWVIGRVFYTLGYSTGQPEKRSWGFLSSASFMSLGGLSAWSAIQIILEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF56</accession>
    <name>I4YF56_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957267.1">
        <property type="nucleotide sequence ID" value="XM_006957205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF56"/>
    <dbReference type="STRING" id="671144.I4YF56"/>
    <dbReference type="GeneID" id="18472855"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56787"/>
    <dbReference type="eggNOG" id="ENOG502QW1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_273439_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF56"/>
    <dbReference type="OMA" id="IQDPDWW"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="384"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131966" checksum="B06C4056A2164C95" modified="2012-09-05" version="1">MKKRQKQQNRKITPSLLSSPLDSNFDTRVKREPEITYPDPSPLPPPELLQSTKSMYLEPPKHTTARPATSSSLATQTPLASLYLVSGLPKDPAAWTYADETSISSVHHSPNAVGRWWRAEALGTSASPGISIPGVDSTGKKKRVGGMPKNEVNKVLAKALKLSFTQEVEIISSSLQPPSTMHSFSFSVSTQQSNNGYAAHSINSQQSNSFKSAWANTQSSNGSKKYDSNSYYRQPDPLGLNDVQPGVDRDGRKTYHGVTLQVWSHADPTRAQAIRKALSTHPRRSESVSVASTSAKRDKVMQKRFGTGNMHGNGGADEASRIVASSYNSDNDEFDETLDEIATIGGTTDILSDVNDVLPNQLNAGLAHEDAPLTGEVPEETLFWLPYCLTLVSTHPIYDILADYLSISWAIFSRDISSHSAQMKRLLEMPAPKHGDIIKLPAAGPTHKHRRVTDEKDGKKRKEKKKKNESSLTIIARMPGAINFGQNLVETNFSMWPFFKALSIDNILTICEIALAPTGRVLFLSRHPQMLGVACLTLQYMVESRGWAGQVHQIVHARDYSILLEDPGQSIIGARTEVRYSLKPPAEVCVVDLDINFVQCINPPIGYVSTGNQREKLRRKLIASFGTFRPDESVPSEFKEAFPSGRFMPMCHIESKGKVPNTIEKVQAPYWWDPQSILGAFDSVLATRTKRPFSIMNLLSRSDKRKLPPLSQSEQKTQQAIRTRAAQFVDSRDELETKIGKLNKRLGFLVSKSEQWKSRFEQFESYAERLSAEASELRGKIDRERKESKRLSGMVIQQTKARDSLVNQLRQTEFLRAGALAELDVMQTQLRKLESERDEMVSHITTHISDAIVQLDIANVKTQSRSNSPWTDSDRRYSHQKSNSVESTIPEEDDYVEKLSNEDDHARALSPNGQATSIDGVSDIENSKSTYEVQKTMSMIQDKLEKALSDLEASKRQSMTEETAEPIQEDIKKTEIIQKDLRNIQRSQQFIRQSQLLQLAKDQEDHLAGLQTRGTKTMKENLPNGEVPSTTYARNSKRRSVHAPARLSLPPRNYHEFGDDEQKEFLFDNATAKDQAAEEYLKQKNQKKEFRKSLARLSSQQPGRPASSLSEDEKYMSSVESPEMLDKKELAAAPTRSNNPERKEHKNITTLRDGEKSEEEQVRNRSEALAFLEGSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF62</accession>
    <name>I4YF62_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_53906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957273.1">
        <property type="nucleotide sequence ID" value="XM_006957211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF62"/>
    <dbReference type="FunCoup" id="I4YF62">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF62"/>
    <dbReference type="GeneID" id="18472638"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53906"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="InParanoid" id="I4YF62"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="28"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="458" mass="49660" checksum="9DDA5F3F199A130E" modified="2012-09-05" version="1">MTEALTTALNGLSLEDLHPLHQTILQGQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKCDQPTCPRPGCYRSYPSNKEPNPLCEQPGCEGSMHLIRHVSFVDCPGHDILMATMLNGAAVMDAALLLVAANESCPQPQTSEHLAAVEIMKLKDIIILQNKVDLIREQQAEDHWKSIVEFVHGTSAASAPIVPISAQLKYNIDAVCEYLVKRVPVPSRNFTDPPKLIVIRSFDVNKPGSDVDELKGGVAGGSILQGVLYIGQEIEVRPGIVTKDNDGNIKCKPIKSKIVSLLAEQNKLNFAVPGGLIGVGTKIDPTLCRADRLVGQVLGAPNALPAIYTELEINYFLLRRLLGVKSDDKKQTKVAKLAKNEVLMVNIGSTSTGGRVMSVKADLAKIYLTSPACTEVGEKVALSRRIERHWRLVGWGTVVAGQILDVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFB9</accession>
    <name>I4YFB9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957326.1">
        <property type="nucleotide sequence ID" value="XM_006957264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFB9"/>
    <dbReference type="STRING" id="671144.I4YFB9"/>
    <dbReference type="GeneID" id="18473601"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59877"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008983_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFB9"/>
    <dbReference type="OMA" id="NVDNEDP"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="716" mass="78441" checksum="DEB41E4B889E3DF1" modified="2012-09-05" version="1">MPLGRKLGESMVFSQTGVPIKAREEPSNPLPIIPLSLLSLSMLSEFLSASVAAPFIFVMVSKFSITHNDESLVGYYTGILGAAFFLSQFVTALMWSNIADRYGRRVTLFVSLFGNALATSLFGTCQSLGEAICVRMLQGLFSGAVGVSRSAVKDITDSTNEAKAYAILSFSWGAGSIFGPIIGGIFESPTVRYPGLFPADKHPFFDKYPYALPCFVAASVLLFGSSLTALVNRDGGSLFNSISLPDNSTTIKERIVTFFKSFKSGQLNEETPISPLQDIHSRYPSYIESDGQAESLRQPQPKQSRSFAQRLLLAQEENVVSITDLWVQSALTREVERYNHEEEAEDIAIEEEGDQSGLGSPNPSGFASHYEDDDDDHLDNNTIDLTNPSERDVEELSSSASIRPSASTGFRNSFRRNSAGLGFSRPSSLVDRGDRLGEENLAKLGSVPRIHQLGMTAARPKSILDNVGLSSQKSWIGLDEQFDDLEGGSSRLGAIPEQNQPAIIEEKPVEMTLMIKLILFQYSFLALHNTTFDQLFTTFLLTDYTSGGLSLTPSHFSTLIAMMAGINIFYQFYLYGKIGPPNGQLTHLQMFRIASLIYIMTYGAVPFVRKLARPESESDLLVMSGLAILTAIRYAATTAAYTSITILINVMSPPSISGLTNSYGQSAVSLSRFLGPIFGGYLWKTFLTGDIDGYRYAFWLVSVMAVIAFLQSFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFF4</accession>
    <name>I4YFF4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_44367</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957359.1">
        <property type="nucleotide sequence ID" value="XM_006957297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFF4"/>
    <dbReference type="STRING" id="671144.I4YFF4"/>
    <dbReference type="GeneID" id="18472327"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44367"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026582_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFF4"/>
    <dbReference type="OMA" id="HRHTIID"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="36121" checksum="59F0A1FF462DDC20" modified="2012-09-05" version="1">MLYAERDDFKDLTPIEQDEGPSPLAPINYSQKYKDAMDMFRAVVNANEKSERALGLTEDIIRMNAGHYTVWHYRTSIIVELGLDLQAELKLMDELSTEYLKSYQVWHHRRLCVESSRDLAVSELKFVAELFYATDDPKNYHTWVYRQWILTYFDKILHDDDRRHEFEFIESLITDDIYNNSVWSHRFFCLFKLGWLETTLDNEIDYVLSLISKAPSNMSSWNYLRGILKVNDQGLNNQRIMQFSETLINAKSASDDMRPPLPALEWLADAALEDKNPIATKRYLELKALDPIRKNYWSWKSHLALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFI9</accession>
    <name>I4YFI9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_27967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957392.1">
        <property type="nucleotide sequence ID" value="XM_006957330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFI9"/>
    <dbReference type="FunCoup" id="I4YFI9">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFI9"/>
    <dbReference type="GeneID" id="18471017"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27967"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFI9"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="444"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="686"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116928" checksum="2566EB4CFF63491D" modified="2012-09-05" version="1">MPTAGQLDTSAIFNADAAARTTAQEAVVKSIKDGGPAAVATLSLPETILGGLAEKKNEGARQGAAELISAIVAGGQFLPVEPYILLSTQHDVFGSLLQAFADKSQGPRDAAVKAVEDIVTVMNNWATAFILPPLLEQIRTAGKWQIKTGGLSVLNKLVTSVPDQMARLMPDCMPVLAEVIWDTKSDVKKAARSSLKKICSLRQVVNKDIEKFIPALQECLINPTEKVPTTIQVLAATTFVSEVDSPTLALMEPLLSRGLAERQTALRRKTAVIIDNMSTLVDSERIVRPFLPKLLPGLIKIEETVADPEARSVVNRAIKKLRSVGNLPDSSDGTDLPEIKTVDLNKVVDVLVAALKNTGDSLAKADDVFIAYIARVAQELSNARCGEETEWSSALVNLISLQLNSTDPSSVNAPAKAVVKELLEKTSADDAEVEHVFPDEEEGEDLCNCTFSLAYGAKILLNTATLRLKRGHRYGLLGRNGTGKSTLMRAIVNGQVEGFPSPDEVRTFYVEHDIDGSEEDTTVFQFVQSDKRIQANDDEIRQGLATVGFSDERQDESIGSLSGGWKMKLALARAILFKADILLLDEPTNHLDVLNVQWIIDYLTSLTHCTSIIVSHDAEFLNKTITDVIYLNRFKIKRYPGNLENFAKLVPEARAFFEIAASEEYSFNLPEPPMLEGVKTKEKSLLKMRKVNFQYPTAKKQQLFDITLQVSLSSRVAVLGPNGAGKSTLVKLLIGDIEPNISGEVWKHPNLVIGYVAQHAFHHIDNHLDKTPLEYMLWRYQTGEDLEEMMKETRQITEEEAEKMKNGSVVIIEGQKRYIEEIVGRKKLKQSYEYECGFKGMSSADNMWFSRDELVKRGFEKKVMEVDTREAQRLGMMRPLVRKEIEKHFEDFGLESEFTTHNTMRGLSGGQKVKVVLGAATWRKPHVICLDEPTNYLDRESLAALIEALKVFGGGVLIITHNREFSESICSEVWAMRDGYLEASGHNWVESNSKGTKIERKEDEEDKFDALGNKIVSEKKQARLNASELRKKKKERMALKKKGIDVDDLEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX5</accession>
    <name>I4YFX5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956916.1">
        <property type="nucleotide sequence ID" value="XM_006956854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX5"/>
    <dbReference type="GeneID" id="18475292"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67756"/>
    <dbReference type="HOGENOM" id="CLU_877733_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFX5"/>
    <dbReference type="OMA" id="TICDQQC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="317" mass="36041" checksum="407BC8499B754195" modified="2012-09-05" version="1">MNSRNNSRSPPPRGYRGYDYDRRPPPGPRSYGGGYNYYSDRGGYSDRGGYSDRGGYSDRGGYDRGGYRGGGYRRPFYRPSPGWRDDHFSRSRPPRSPPRYIPSRKPYSGGRGGYRGTAGRDYDGYHSHHYNNTHRPPPINTSYDSPLPSPSSVREVITRDHDDGEEGELKEEFPVVEPHQARPRIPSASATFHQRKSSYSPTTNSRSPRTPEVTTFEDKPGRFQTKTKISTTSITKEIVYPESPPKPTREVKIRQSYTLDLDEQLEKLKQERTKGVETGRLNDIATSHSINDLRFYDIELAGQKLKSSICDQQCVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG37</accession>
    <name>I4YG37_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956975.1">
        <property type="nucleotide sequence ID" value="XM_006956913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG37"/>
    <dbReference type="STRING" id="671144.I4YG37"/>
    <dbReference type="GeneID" id="18472831"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56603"/>
    <dbReference type="HOGENOM" id="CLU_093261_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG37"/>
    <dbReference type="OMA" id="NTHRSAP"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="25642" checksum="89EA5F9402CFE120" modified="2012-09-05" version="1">MLLGNNNPFSTLVEQEQQAREREQQEQRRREEEERQSISQALQNTPMESSNSSQSNTYIPPPPLPNRPKSPPQPPRPAESSTASFEQRYEEEEPPPYEEVLSDRVLEQGPRRPFTTAPQVQPQQIPQTPIHTRPNGYPSSGMQQTQSYSYNPSYSHYPNRMPVRGPPINGIISTGRPPPGAVVFQAGDPRIGGTFCYKCDGTGKRTDWLFGITENCYKCGGIGRRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGJ0</accession>
    <name>I4YGJ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_56700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957115.1">
        <property type="nucleotide sequence ID" value="XM_006957053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGJ0"/>
    <dbReference type="FunCoup" id="I4YGJ0">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGJ0"/>
    <dbReference type="GeneID" id="18472837"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56700"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024722_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGJ0"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="421"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="513" mass="56605" checksum="A1287F68A80078B5" modified="2012-09-05" version="1">MVFVSKVLLRQPIKLAVFGSGPSAFYLSQRLLNQLDKGVDDSIHMYERLPVPFGLVRYGVAPDHPDVKNCINSFSRAAEDSRFQFFGGISVGSHRKIEEHPKILNVPLEDIAKHYTHLAFSYGASRPTHLANVKGSSGSSDKLSSGVYSASEFVGWYNGHPDYMHLHDKIVSDLKRAKKVAIIGQGNVGLDIARMLVTTDYSKLSTTDIPIGVLDALKNSTVKHVDLIGRRGLSQVAFTAKETREMMHLPHVAMKSVDSNTMDEVMKEGDASGDKEWRAKKRILGLLRDGSECKLEDADRSWALKFLLSPAEYIGKNDTLSSIKFGVNKLTKSAPSTEVLGSKPATQSPPRILATPTDQSYEEDYDLVIESIGYRSEQLGDIPFDSRKGVILNTGGRVIDENGINIPNVYSTGWASRGPVGVIASTMYDSYSVADTILQDIHNGDDPAPSTELNWAPSIKSPKEGVPPVVDQGAIKWEDWRRINDAEVANGKQLDKIREKFLSIDEMFNVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGR1</accession>
    <name>I4YGR1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ADP,ATP carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956549.1">
        <property type="nucleotide sequence ID" value="XM_006956487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGR1"/>
    <dbReference type="FunCoup" id="I4YGR1">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGR1"/>
    <dbReference type="GeneID" id="18473365"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59464"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="InParanoid" id="I4YGR1"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="228"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="36048" checksum="D82AABEFDFEFE4D3" modified="2012-09-05" version="1">MKTDRSSQDRRSFDYVWRSMVAGGTAGCVAKTAIAPFDRVKILFQASNPEFKKYAGTWTGVFRALRPIYNANGVRGLLQGHSATIARIFPYAAIKWAAYEQARHFFIPNEGESTPFREFLSGATAGLCSVICTYPLELIRVRTAFKTRSKGRVRLSDVMRDIYYEGQPPPSKTATTAKFSRKLLNKVSLLKFYRGFSMTMIGIIPYAGMSFLVYEQASKSKIRSFFKSKSAGDLLCGGIAGAVGQTSAYPFEVIRRRMQVGGLLHPDRFVNFNETCSLIYRQSGIRGFWVGLSIGYLKVIPMNAISFATYNLAKKMLFREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGS9</accession>
    <name>I4YGS9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_15240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956498.1">
        <property type="nucleotide sequence ID" value="XM_006956436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGS9"/>
    <dbReference type="STRING" id="671144.I4YGS9"/>
    <dbReference type="GeneID" id="18470653"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15240"/>
    <dbReference type="eggNOG" id="KOG1108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070889_2_0_1"/>
    <dbReference type="InParanoid" id="I4YGS9"/>
    <dbReference type="OMA" id="WTWGYRG"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="170" mass="19301" checksum="16771F1B7CC08601" modified="2012-09-05" version="1">MFKWLFYAFAIYLTLALFLFDDIFLGYKGKYRNLKTYLPRPPQRKFTPEELANYDGTHGDEIYLAVDGLVFDVSANKRIYGPGGMYHAATGKDAARAFVTNCFKDQATYDTRGLDEKELSQIKSWQAFFDNHKNYNLIGTVENPAIDPSTPIPEDCGFKLKAKTPKGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGV5</accession>
    <name>I4YGV5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_67500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956591.1">
        <property type="nucleotide sequence ID" value="XM_006956529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGV5"/>
    <dbReference type="GeneID" id="18475260"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67500"/>
    <dbReference type="eggNOG" id="ENOG502S4C9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428747_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGV5"/>
    <dbReference type="OMA" id="MRWFIPL"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698150" evidence="6">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="91" mass="10637" checksum="8008845FF332BBAE" modified="2012-09-05" version="1">MFCLRWWLLMFLLPFPTASPIILSLFMLSYVIYQKPCPYCFVLLLCLFASTCHWGVGAPDTCCWFTNKASISQPSWELDLRKFGQQLIIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ3</accession>
    <name>I4YGZ3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956626.1">
        <property type="nucleotide sequence ID" value="XM_006956564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ3"/>
    <dbReference type="STRING" id="671144.I4YGZ3"/>
    <dbReference type="GeneID" id="18475266"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67533"/>
    <dbReference type="eggNOG" id="ENOG502S4IY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940742_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGZ3"/>
    <dbReference type="OMA" id="WEGNDER"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="34699" checksum="8F2B75CCF153AB11" modified="2012-09-05" version="1">MSSRINTEQQSNYWLQPSPIDARSNSSTVSFAGTEQRNHDREEAMKRLGQVHKNDKKNRPLDIFLIFIQTVLPSLFTGGVNFVIAWGMYKGKFTLWQSEKLTNIATDQEQISWWYFPCPLSGDLAVTIFIQGTLTYLFTSITLTLDYYAQRRVPWHAFNIPSNFIERIPFPRVFLLPHIPIPPGTRRSQKLPSIGLIKSLITSPSALICTIISGLVSSVIIFMFIFPISIAIMAPLIGGRDNVAHTWWSEGLKGVFGFVLNMVQAPLVSIYVVSMLSNKQVDKRRSFISSYASTSPIMTNEKAFTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHJ9</accession>
    <name>I4YHJ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956815.1">
        <property type="nucleotide sequence ID" value="XM_006956753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHJ9"/>
    <dbReference type="FunCoup" id="I4YHJ9">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHJ9"/>
    <dbReference type="GeneID" id="18473454"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59611"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_3_0_1"/>
    <dbReference type="InParanoid" id="I4YHJ9"/>
    <dbReference type="OMA" id="GWKNAQT"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="463" mass="51931" checksum="0EBF2DA852BCF6CB" modified="2012-09-05" version="1">MIARSVRGLYSVGGARSAIASRRLTSIKNHRTIFSESKKAEELATSSLPVKAVNDPPAASTATSTAVESTTETPAHLQNIVESTTEPLKYGDLAELGLCNKWYGFVQQALEAVHVSTGLPWWATIAVTTVSLRLALFPLLRNSLIHTSRMAVHQPEMQAKINAMTAAKKQGKDQEAAVLGQEMRMFMKEKNLKPLRGLVLPLIQMPLFIAFYFGLDDMARLPLKQMAEGGFGWVQNLTVPDYTCILPIISSSLMFKSISMGPDGSGSVQSPQAQKMKPFFQIGSFIIVPMAWWLQMPSAVFIYWCTTNAFSLAQSYLLSSTAVRKSMGLPSLDTIAENNKKNFPQQYASENQKQPGFMESVKSSYNTFREEFEEKKKPMLEEARQREKANREKLIRQSYESERSDKGLYESAEAAESKGKDDEVSHKNPTLLAMDDEKRARALKNEQQRLARFQRNSKRQSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHK3</accession>
    <name>I4YHK3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956818.1">
        <property type="nucleotide sequence ID" value="XM_006956756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHK3"/>
    <dbReference type="STRING" id="671144.I4YHK3"/>
    <dbReference type="GeneID" id="18473455"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59614"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750504_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHK3"/>
    <dbReference type="OMA" id="HENGNNA"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="369" mass="40944" checksum="684F66D1B0B5B4A1" modified="2012-09-05" version="1">MGRRKIQIKPLKDDRNRSVTFLKRKTGLFKKAHELGVLCSADVAVIVFGHNGKLYEFSSGNIEKILMKYTEHEGESERRCPRDFNDDNESEQDFNEFEEERVKEEPEVQVKATTETPTPVKSEPVKEDIIKEDIKPRIEIGDLDDKPSSMPSTHAGPSSSSLPPPPRSPKPVSPFDPSKYSPYPPLSFLPGYPHSPNTQAQHDQMMNWQYAQMHAHAVSQHQQQQTRPQQSTNQFLSPSNTPVVQSHSPQASQSMLQTPNVSSVPNMGSMPWYNSMPPIAWPTPAPGLSASMLMDPFQFPLDGLSTSPSDGQSGFQWPIPPKEATNQNNSTTAAGSEGELSANSGTTLEVPNSKEPIQSPRSTKRARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHN7</accession>
    <name>I4YHN7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">STE3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956158.1">
        <property type="nucleotide sequence ID" value="XM_006956096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHN7"/>
    <dbReference type="FunCoup" id="I4YHN7">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="18473232"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59221"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHN7"/>
    <dbReference type="OMA" id="IPPLIWH"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="41808" checksum="63B6B58E3495B3C0" modified="2012-09-05" version="1">MSLVAIPIISIIAVIITILPCSWHYRVGNTNILILTVWIIGVNFIYFINSIIWHDNVDIHTPVWCDITTKLVIGANIAIPATAACLLRNLSGIATASVVSTSRKDMRKKLYLDLTYGVVVPIIYMALHVVIQDRRFNIIEGIGCMPVIWPSWLSLVHTSLLPFICAIVAAYYSFKTFRAFYKYRETFMDLFKMKKYGLTKSKFIRLIGLAMTIFILTIVAAVVQLVVNLQANSGRLLPYKSWDQVHVYFSKIYQVKLSELNEHQLGANIASWLLPIITAIIFFFFFGFAEESRKEYVRCLLFCFPFLRARLQRSTIPNNGHVSTISSSPSQDYDDFDKLKDCSRGQSEEYELPVLRASYLESRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP3</accession>
    <name>I4YHP3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_35040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956163.1">
        <property type="nucleotide sequence ID" value="XM_006956101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP3"/>
    <dbReference type="FunCoup" id="I4YHP3">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP3"/>
    <dbReference type="GeneID" id="18471900"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35040"/>
    <dbReference type="eggNOG" id="KOG0820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_2_3_1"/>
    <dbReference type="InParanoid" id="I4YHP3"/>
    <dbReference type="OMA" id="GSEAYCR"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="49"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="318" mass="35884" checksum="FA0A1A5FA3244526" modified="2012-09-05" version="1">MPKALKSATEKFSRSHQPAAKSDSNSGGTSNPLFNTDRFGQHILKNPLVAQAIVDKASLRATDKVFEIGPGTGNLTARILEKAKSCQVIEMDPRMAAELSKRFQGKPEQRRLEIVIGDFVKADLPFFDVVISNCPYSISSHIVFRILSHRPICRVAILMFQREFALRLCARPGTEMWCRLSANAQLYSKIDHIMKVSKGNFRPPPQVESSVVRIVPLDPPPPVKFEEFDGLTRVLFTRRNKTCRSNFTAAGVYDMLESNRKAWLTEKNEMIDDSENIKSRVERILVQTGFAESRAAKMDVDDFLKLLSAFHDENIHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT3</accession>
    <name>I4YHT3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59246</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956202.1">
        <property type="nucleotide sequence ID" value="XM_006956140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT3"/>
    <dbReference type="FunCoup" id="I4YHT3">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHT3"/>
    <dbReference type="GeneID" id="18473246"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59246"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="InParanoid" id="I4YHT3"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="87"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="304" mass="33113" checksum="B1B8EE0D5CAC6F1F" modified="2012-09-05" version="1">MFSIFNRAASAQMKAFSRKASTQAGSASNISNKGAAIAASISGLSAALYSYQFGVFDEAFASGLEEGLHAPHFPWSHNGYLDSFDHNSIRRGYQVYREVCSSCHSLDRIAWRNLVAVSHTSDEARAMAEEVEYTDGPNDQGESFQRPGKLADYMPAPYPNEEASRAANGGALPPDLSLMVKARHGGADYIMALLTGYQDPPAGISVAEGMNFNPYFPGGQIAMGRVLFDGLVEYDDGTPATTTQMAKDVSTFLSWASEPEHDDRKKMGMQAVIVLSAMTAISLYVKRLKWSPIKTRKLVYNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHV0</accession>
    <name>I4YHV0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_27046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956219.1">
        <property type="nucleotide sequence ID" value="XM_006956157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHV0"/>
    <dbReference type="GeneID" id="18470974"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27046"/>
    <dbReference type="HOGENOM" id="CLU_1556474_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHV0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697814" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19806" checksum="9A2FA6C2F8F2416B" modified="2012-09-05" version="1">MAVATILFLTIYSIKSIKEVYDREPKTLVDVSFDLSRIYEGTHGNSSSNITNDYSTDSIDATFDSSMANIYLHTPYASIDNDVDDYDKLTVVYLVDAWSIGDRERLRAHYPVSAPVDLLFGLKWSEDLEWKYLQTVENARYGDIVELVAESYWVYATYRALARRQNMKGWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHX0</accession>
    <name>I4YHX0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_62232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956238.1">
        <property type="nucleotide sequence ID" value="XM_006956176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHX0"/>
    <dbReference type="GeneID" id="18474725"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62232"/>
    <dbReference type="eggNOG" id="ENOG502QWRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024407_2_1_1"/>
    <dbReference type="InParanoid" id="I4YHX0"/>
    <dbReference type="OMA" id="IPFLELW"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="32"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="495" mass="54462" checksum="11629280DFDBF368" modified="2012-09-05" version="1">MVQERPLLVLIGFYYFLQFARIIADYVFSAGLLGEIAVGIIFGGPLAGILPHEWEETWLTVGYLGLVLIVFSGGLDFDAQVFLRSIPIAFIAAFWGVLLPIAFSFAILWKAFGYPILHAFTAGCALSSTSLGTTFFVLQSQTKKGLNVQATRVGTLLTAIALSDDVIALVLLTVVQSLGGGSNSTLGWIVGKPIVASVALSIVSPIVVYAFRPIYRRFLEVPISRYGGYRGATTVGFLVLCAYLAISFYIHTTMLLGAFLAGMTLAVWPSDREGVINYKHIFEEIFDPLLKRYFASLFFASIGYSIPFLDLFTAKRFWQGLVYSVFMFIGKLLVGIWIPIRDLVTKERFKVDEESDKYKTKIHSSKPNKDSWIAGLILGSAMLARGEIGVLILQVSLTTSQSNAGSDNAISVMDNETYLIGIWAVAWNTIIGPVAFGLMVKYFGQRVIDSHWGDTARLRIERQESIYAAPTFNTEATITQETKVKGTGTQDKSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHX2</accession>
    <name>I4YHX2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956240.1">
        <property type="nucleotide sequence ID" value="XM_006956178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHX2"/>
    <dbReference type="GeneID" id="18471241"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31069"/>
    <dbReference type="HOGENOM" id="CLU_1817297_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHX2"/>
    <dbReference type="OMA" id="GYNNSIY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698947" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15598" checksum="7BF97114AF3AB2FE" modified="2012-09-05" version="1">MKLFSTLALTALAVGVTAWNDGNSEVDSNSFSLLIEKSVGDADDEFNKSINTSLQTEKSPILNIPKNKFVIRGNQCYQSVGLPPRDDLPESPYVNIGLGHCRDQDNDDLQIIYAGNTINVGKDDRCRLVNDDNLSVRCVIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHZ7</accession>
    <name>I4YHZ7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956262.1">
        <property type="nucleotide sequence ID" value="XM_006956200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHZ7"/>
    <dbReference type="GeneID" id="18471246"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31092"/>
    <dbReference type="HOGENOM" id="CLU_047639_6_0_1"/>
    <dbReference type="InParanoid" id="I4YHZ7"/>
    <dbReference type="OMA" id="VINDIWA"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698948" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13834" checksum="AB88BB6B13FE6F73" modified="2012-09-05" version="1">MFSKTVIVAAIASLVAAAPTPAGAPAAKRSSDTYGNMATYYDAETGNAGACGNYLSNNDRFLAVSMNSDIPCGKWMGFNVNGKTSYGYVADKCASCADNHYDMSMTLFNEFADYSQGVVNDIWAWELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI35</accession>
    <name>I4YI35_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIE beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956297.1">
        <property type="nucleotide sequence ID" value="XM_006956235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI35"/>
    <dbReference type="FunCoup" id="I4YI35">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI35"/>
    <dbReference type="GeneID" id="18473278"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59300"/>
    <dbReference type="eggNOG" id="KOG3095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056580_1_0_1"/>
    <dbReference type="InParanoid" id="I4YI35"/>
    <dbReference type="OMA" id="RTKKDNH"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="8">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="275" mass="30763" checksum="B1378D44FA72E596" modified="2012-09-05" version="1">MPSPSVAPTPGPSGVDDGIPIAGSAAAAAQAAAKRKKANEIYSQPRDTGVGMHINSQLAYLVQFIKDYNAPIRLEDLIVRSGIELIRTPGLLDLFNSHDRVQHDTKLDLYSYRHDFPMKSKAELLKHVKGYAPRGGMRVNLLKESWSGAPAAIDELERENEIVVLRGKDGQGMRTVFENNVKDAIEVQEEFRGLWHSLNVPPESEVARDLDDAGLKRTSKTEVAPAKKGRQLKQARQDHQHSLARARYRSQQGFRSTRKVNYIYTHIALHRIIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI60</accession>
    <name>I4YI60_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956320.1">
        <property type="nucleotide sequence ID" value="XM_006956258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI60"/>
    <dbReference type="GeneID" id="18473286"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59309"/>
    <dbReference type="HOGENOM" id="CLU_1327303_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI60"/>
    <dbReference type="OMA" id="NETQHET"/>
    <dbReference type="OrthoDB" id="3365370at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="209" mass="24638" checksum="5272382077D80871" modified="2012-09-05" version="1">MEPSTSAKVPEQHEEEREQQQFRSYPGKVVVHGRATERAKITSKYKRAYLIVRERWNEAQHETVEIKDKIKKAQSALTEVNNENDVLLEALMKCDPELAQKYLLDCQHQQQQQQHQDQHFIEQTTHIPQDPQYLRNEAEQLPVNTIQHDRFAHILNQEPEKPHNTMNPFEQEQLHYSLQVQPTVNNSKRSIDDIISSSDINEEAKRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI89</accession>
    <name>I4YI89_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_31168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956347.1">
        <property type="nucleotide sequence ID" value="XM_006956285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI89"/>
    <dbReference type="FunCoup" id="I4YI89">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI89"/>
    <dbReference type="GeneID" id="18471258"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31168"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="I4YI89"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="162" mass="17386" checksum="CA4CB6AC4E0D14A0" modified="2012-09-05" version="1">MANVFFDVTANGSAVGRITFKLRDDIVPKTAKNFRELCTGEHGFGYKGSPFHRVIPQFMLQGGDFTRQNGTGGKSIYGEKFADENFTLKHTKPGLLSMANAGKNTNGSQFFVTTVPCPWLDGAHVVFGEVVEGLDVVKKIESFGSGSGKTSAKIEVANCGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIH1</accession>
    <name>I4YIH1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956426.1">
        <property type="nucleotide sequence ID" value="XM_006956364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIH1"/>
    <dbReference type="GeneID" id="18472789"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56271"/>
    <dbReference type="HOGENOM" id="CLU_1662170_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIH1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698043" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="159" mass="17662" checksum="071E01953FD72F18" modified="2012-09-05" version="1">MFGNNRFPLYLPITILLCSCINMVVAEHISESKNKEYFDDNRLLTSGYEDMGIQARNMLHSGDTSAYFKLLNYSFGASLVSCAAVQFGSYCYGANHADQVNDLAYKAVYDVDASKEGYYQFQLYNGEATDDCGLLTMQPTGYLDNSVDRELSNLCGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIH9</accession>
    <name>I4YIH9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_27229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956434.1">
        <property type="nucleotide sequence ID" value="XM_006956372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIH9"/>
    <dbReference type="GeneID" id="18470982"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27229"/>
    <dbReference type="HOGENOM" id="CLU_931275_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIH9"/>
    <dbReference type="OMA" id="WRANIIN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32687" checksum="51E2CC7A9ABC76DB" modified="2012-09-05" version="1">MSDYQTLLKSIKDKGIVFTSSKDVEAVVEYARNGARILVGCESEESAQKFQGIDNVKTSQLNVSDFGQLASFFDNALKYLGNVDIIVANSTRREAQNIFSIENKTPTSQKPDLSIVNNNVYGILYTVHTGANALRKNPSNDKAIVFDGDGDAGPVDIENAILHASLEPNFSCTHAMFTSGVSEGWRSNIINPKQALDKDTLATAEKYDLTGVENEKFSRRHAILVAATMQSTPASVIVDETGLSTIPHPIIRMYGIEKLKMRLRILGKIAVAVRTGKVKKWATAALIFGCTTALARRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP5</accession>
    <name>I4YIP5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_58965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955684.1">
        <property type="nucleotide sequence ID" value="XM_006955622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP5"/>
    <dbReference type="FunCoup" id="I4YIP5">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIP5"/>
    <dbReference type="GeneID" id="18473095"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58965"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIP5"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="33881" checksum="697CBBC77F9106AC" modified="2012-09-05" version="1">MRLQFIDIALNLTDSMFRGVYRSPKQTHPDDLKNVLDRARDVGVVSAILTGGSLSESKEVHALAEELDGFYSTAGLHPTRSNEFNESFINDLEAFIKANRFPGTSNGRVVALGECGLDWDRLHFSDKPTQIKAFTEQLKLAQKLNIPLFLHSRNCHDDLVQTIKSACGDNLPKGCVHSFTGSIDEMQELVSLGFYIGLNGCSLKTEDNLDVAKAIPLDRLMVETDAPWCSVTSTHASYPHLETLPDEYKLPPAVKKEKWSANAPVKSRNEPGFTPAIAHIIASAKNVPLDTVAEVAYRNTRELFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIS6</accession>
    <name>I4YIS6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955712.1">
        <property type="nucleotide sequence ID" value="XM_006955650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIS6"/>
    <dbReference type="GeneID" id="18474671"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61701"/>
    <dbReference type="eggNOG" id="ENOG502QQA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_7_0_1"/>
    <dbReference type="InParanoid" id="I4YIS6"/>
    <dbReference type="OMA" id="CHLIAYV"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="89"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="502" mass="55476" checksum="5530519438546034" modified="2012-09-05" version="1">MEDNRDKSPRHVSTVNPTLVNLDRDSRRSSIESSSSQTHLETFDGSLNEKNNSSGRINLEGEKEALEERTEKLYFFHDKPYRLKKKLVLFAMTCLSFTTIGFNDSAVGALIPQMEVFYNKSESIISLSFLANSGGYFISTIASSYMIHHLPLYIVMMISSFVYAAGSLIGTFKPPFAVLMISLITTGFGAGLLETAATIVLVHFEDGPLISLAYSFFSIGSMSSPFLVGGLRENDHPWERYFWLPVAMAGLLFILQWFVYRSYKAPIEDEGVQISASQRLRIICTNPTCVLGICLDFLALGIQDSWSQWASKYLQDTKELESGVPQLAQGTFWAGVTVSRIVLSYAIPLVGENLSSLLLVVSFATTTAGMWKLPTGNIAGAMCLNVLLGFADGPMLPLILSGCTMSLPHYLKQPASSLLVCSGLLGSSILPLVLGQGIDKFNTNIIPGVLIVALAIMFCALIVMHLFKYRDLTEQNDNPRSLFQFMRITYTFPQRPKDTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIV8</accession>
    <name>I4YIV8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955742.1">
        <property type="nucleotide sequence ID" value="XM_006955680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIV8"/>
    <dbReference type="FunCoup" id="I4YIV8">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIV8"/>
    <dbReference type="GeneID" id="18473114"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58998"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_1_2_1"/>
    <dbReference type="InParanoid" id="I4YIV8"/>
    <dbReference type="OMA" id="FKSQYWR"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="210" mass="23930" checksum="FE679BFEE8703CD3" modified="2012-09-05" version="1">MLNYLNQIPTVSKFWLIGSVLVSTLVQVNVISPLNLYFSFHSAFINNQPWRILTTFFYFGDISIDLFLHLFFFVRYSRMLEEEQFASNKADYVWSLIVMSTMLLAMSPLINLPFLSSALSSALVYIWARSHPNAHIGLLVFIIRASYLPWAIVLLSWLITGRATAATTELAGIVVGHLWYFSKSIWPKELAAKGKPLLPTPRILTELLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ53</accession>
    <name>I4YJ53_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARF/SAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_53135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955829.1">
        <property type="nucleotide sequence ID" value="XM_006955767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ53"/>
    <dbReference type="STRING" id="671144.I4YJ53"/>
    <dbReference type="GeneID" id="18472604"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53135"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="I4YJ53"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="20781" checksum="B42FAF6AD9171AF6" modified="2012-09-05" version="1">MGATLSGLANVFRPLLFWTKGKECRILMLGLDAAGKTTIVYRLQLGEVIQTIPTIGFNVETINYSGLQLNVWDLGGQTSIRPYWRCYYANTQAVIYVVDSTDTERLPTARSELITMLSEEELKDAKLLVLANKQDSPAALPVAEVSLQLGLDNLKDRTWSVRGCSAIREDGQLNEALNWLVDELKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC8</accession>
    <name>I4YJC8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59078</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955897.1">
        <property type="nucleotide sequence ID" value="XM_006955835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC8"/>
    <dbReference type="FunCoup" id="I4YJC8">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJC8"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
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    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
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        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="19">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="18">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM24070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="653" mass="74366" checksum="593E6ED585BD6353" modified="2012-09-05" version="1">MDKNWDEGLADDDPELLDEKLFTRDASLFVIDAAAGMQEYPPSQDPNDRIDEEMPLLHRTFDAILRCLKRKAFNSSDDLVGVIIYNTEETKPDKEGSDVKEHVYCLQPIEQLNGNNIRNLKKLVDGSRADPELLSRKFKPAVFENNRTSMPIGNLYISCNRFFRNNPQTKNASKRIFHITCNDEPQKNAPEDWLTASRTNASDLLESEIIIEPFFIAPSSSDFDIKTSFDVKKFYAQILPKKENNEDVTDPSMGEGFAKFDNLEEKLRKLEIPKRTSFTHMFELGDNFSISVKGYRTVVDQKFFPYVMVAENKKGELEQTEKETRLQDEFTLNEITPSEIKQGFVLGDKSSDGALVIPCNTQTYNSIRTFDLPVGLKLLGFQDIDTLSPLHNVGTASFIYPTEDLIEGSTRTFSALLKSCLKLKKLALVRTVMRKNAAPIISALLPQEEVIDSDDGSQITPNGFYLIPLPFADDLRSVPQIENMKANDEQTEAAGRWLKKLRKKSGYDPKEYENPYFRLLRRNIESQALDEPLDENDVKNDKTLPPIEQMKDRAGGLIDEWKSTLGWDVVKVDPEVEEAKLADVKPNKRKIDATLDNDVDDSAFIQKWRANQLDKCRLDDLKNFCRSHGLKVQGRKSDLIERISAKLESSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM4</accession>
    <name>I4YJM4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_67014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955987.1">
        <property type="nucleotide sequence ID" value="XM_006955925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM4"/>
    <dbReference type="FunCoup" id="I4YJM4">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJM4"/>
    <dbReference type="GeneID" id="18475198"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67014"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJM4"/>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="290" mass="33342" checksum="67010DDFA9266613" modified="2012-09-05" version="1">MKLEDIKQFYYQGSYQTLINAVDSNNLNDLDDRIKFIYSILSHLALKKDLPSIDSELSQSHIELAVIQSYIDYITNKEKVESLDKLRDYLIEIESEDHQYKHLFNVLAATIFWKSGEIEEALSTLNAGQGVKDVESVALLIQIYISISRLDLAKNEYQHARIWADDHYLIQLSEAWLGLAGTSTSTNSSYEQAYYVLEELPDRDEPYNKLLRAIAHGALQHFEEAQVELDSINSEDEYSIMNEIVISTHLKNKDTNELISRLSSINPDNILVNDLKRKSAEFDQLSKQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW7</accession>
    <name>I4YJW7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956075.1">
        <property type="nucleotide sequence ID" value="XM_006956013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW7"/>
    <dbReference type="GeneID" id="18473208"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59175"/>
    <dbReference type="HOGENOM" id="CLU_2414983_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJW7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="92" mass="10550" checksum="9883AF68BC3C042B" modified="2012-09-05" version="1">MKLVLRHLIVILYAKSQAKDGFKYVLLGSMDDIYSQKFNSLGNHLQESLTSTLERVKTTNIGLNMDKDVAKQKSDRVIPSDRQLDPKDVKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJX4</accession>
    <name>I4YJX4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956082.1">
        <property type="nucleotide sequence ID" value="XM_006956020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJX4"/>
    <dbReference type="STRING" id="671144.I4YJX4"/>
    <dbReference type="GeneID" id="18472765"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56057"/>
    <dbReference type="eggNOG" id="ENOG502SDVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274663_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJX4"/>
    <dbReference type="OMA" id="ELETTCE"/>
    <dbReference type="OrthoDB" id="3357224at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="878"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127772" checksum="F6F29A0084DC33C1" modified="2012-09-05" version="1">MTFIPGHRTIPSQALHLKPVTKKQKKIQLRLPSKDGRQPSEVRNQDSEIPTPSAIISSINSPDKLEFNPIDADIIDIYLPGKDAWDAIKQRAITNQLDKLGIETAPTPTEQKYSDSFVDPPSKHSKSLSFNSSESNLLDFKMDKFFNNSPLNLEIKPPSRFGSHHSSSLSLNNFNTTNLSPGLSSPSSYFPNSPRSPGNYLNIPDFQQLSRKSSEGPSSHHPSSLADVEEEQEEEDVDNHVKVEDVDNNVPEQDILGTQDVQPADQDANTSIIPDEAPQLPPPSFQELSRGFGYEVESDEEQMQDQENNHKKTLSGFTMRSSNQVDEDQVDEDAHVEHIDDDVKQTVDDSQTDHNTTDTEDHAFNYELQKKDIDDHDQQENTIKPAAALNSALKPTVAEFIPSIPFKDSTNVYDSSSFKFGLKQSQEQEEPIEPVQASQPMEIPNSNPSTKRDRAPTVESADNWSGFDVNSDNGGDYDDMFSNPSEEDRALQNRFNKRMMSNNAFQFGGLSGSSQLNRKKSLSATAPAFEPGNFTFKSELSMPTADTFEVKENDTPAKRGRLNSDTSPNQSIGWIQPFEIKREPVNEDVYEIHQTEEAPDSRITLQDVYYKLEQLSVNLGARNDLSKDDVVRLLETDRGLILEGLERLDEATQHTSSMDRLSLLADLLAGLKPQISSLKPDENALALKLSEAITPGIQTLVDLASDKKETAAIITEELARSTIFSSIKDQVKEMLDSHAELYKEHSNNLSNTQAEIFTNASSLQAKLGDLPDGITDATNALLSATNKLDNYSNIPAELTKLREYVNENSELRNEISKSQSMHGRLRSEKDRIIDKLKVVEEERDFSKTEADLSRQAARKVESDLVKIEATNGSLIESLNGMSIKVSQAEEQVSDLLEQKQAWYAADRDYQIRVKELEMQLEMLRKERQNDLKTITEDKKRTEEVHKSNQELSSMLHESRAEVSRVSSEFEQLSRNSMQVNQELMTRNQSLEISQMELDKAYQTSNMEKLVSEQRLHEVEMAYGELQSKTEQMESRSSDDKALLEEATSTIERLYQEMSTKQRDIESLNEQLEQAQDGRRTPTNNKFSEKSLNNYSNGVTKSAHAPSTPISPAYSSASKFSVTSTATYQADDGWFYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK00</accession>
    <name>I4YK00_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_30978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956104.1">
        <property type="nucleotide sequence ID" value="XM_006956042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK00"/>
    <dbReference type="FunCoup" id="I4YK00">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK00"/>
    <dbReference type="GeneID" id="18471226"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30978"/>
    <dbReference type="eggNOG" id="KOG2768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_0_3_1"/>
    <dbReference type="InParanoid" id="I4YK00"/>
    <dbReference type="OMA" id="CMREGNK"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="165"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="296" mass="33068" checksum="674C96363A3A3C54" modified="2012-09-05" version="1">MTDAEIPTVDQNELGFDAALKKKKKKKAVNFDSLDAPEAGGAAPEAENEDDMFAGIKKKSKKKTPVEGEEQTPPADDADDFADLKKKKKSSSKKKAFDLEEFDKQLDQGKPEEDAPSDQPDPLSESTGENGEPWLGTDRDYTYKELLSRTFKLLHSQNPALVTGAKRYTIAPPQVVRDGNKKTAFANIADICKKMHRQPEHVIQFLFAELGTSGSVDGSQRLVIRGRFQQKQIENVLRRYIVEYVTCKTCKSPETNLTKENRLYFMTCESCGSRRSVAAIKSGFQAQIGKRRAQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y531</accession>
    <name>I4Y531_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668262">
        <property type="protein sequence ID" value="EIM19073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960880.1">
        <property type="nucleotide sequence ID" value="XM_006960818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y531"/>
    <dbReference type="GeneID" id="18475136"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66698"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y531"/>
    <dbReference type="OMA" id="SHHYLIS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="23538" checksum="E696F579E87F2107" modified="2012-09-05" version="1">MKGREGTIVQLNWIPGHTGIYGIELADRTANEGRAKCNHYTNIDFTLRTSYSAMRRRMRERYTAPLKIEASRLSVIKSNTSKTSAGKLTAAKTAKILNELPRATRCLATQLRTGHFPTTKSYRYRFKLIDSPKCRTCGVDDNISDRVFICRRHMMTRMTLRRKITKINVRFELGPMLRNAQALQALYKFFKPQLTTHQRYSGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y579</accession>
    <name>I4Y579_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960848.1">
        <property type="nucleotide sequence ID" value="XM_006960786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y579"/>
    <dbReference type="GeneID" id="18474650"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61635"/>
    <dbReference type="HOGENOM" id="CLU_607215_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y579"/>
    <dbReference type="OMA" id="ATAWNDW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697405" evidence="1">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="451" mass="50516" checksum="9CF5720AE1457AA2" modified="2012-09-05" version="1">MIIKYFNIFLWWTLSSLLLFSLSSAYVVGKPSQNVNKTSRSTFNDITLSAQFFDTTTIDTSVKRGSHPLEFPEMVRLETNRDSKNPSTNKFLVRKEKAFLRNSYQRTRTEWDGSKALVDRGRVVDFVWAGSTAILSPNPYSKGLAIAGMACSVTGWALEALRKVPEPKAVSYACSTLSFLGAFWNAWLSRNTIQQAYLDFIGKTPPGENFFSAHEMATMFTGGRTARDNSYFGQFEQKLANDTIKVFNSAKGILFHDPKDKYSVVTLSAMIGASKDKPATIAISKDLRLEHPYLKAWWETSGSNIVLRTHSVSLHQKDKLQKRLSHEGEQPCIDEIEEVEYSNDKLYACNERAEGEYPAQVMYGENFYGDEQQWERTDYNIGAEAGEDNGGIPFANRVMTDADANQWSDACLCLQDNGQWISTGAVQLARDGESYYGQDACYAGNCGADGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5D4</accession>
    <name>I4Y5D4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_34241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960797.1">
        <property type="nucleotide sequence ID" value="XM_006960735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5D4"/>
    <dbReference type="GeneID" id="18471839"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34241"/>
    <dbReference type="eggNOG" id="ENOG502S76S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143683_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5D4"/>
    <dbReference type="OMA" id="AKWSHEL"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11594" checksum="453CF3493401A42D" modified="2012-09-05" version="1" fragment="single">MGLFDIFKNKHESAHQDVYGGKKHESHLSHELIGGAAAFEAVHAYEEHQRKEGKEVHHEKFKEIAAGLAAAEVDKLFETKGLDHIDKERAKHHAKQQVEQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F4</accession>
    <name>I4Y5F4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_66593</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960768.1">
        <property type="nucleotide sequence ID" value="XM_006960706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F4"/>
    <dbReference type="FunCoup" id="I4Y5F4">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5F4"/>
    <dbReference type="GeneID" id="18475130"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66593"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="InParanoid" id="I4Y5F4"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="41"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="265"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="627" mass="70547" checksum="F78D02EEE0BFEFEC" modified="2012-09-05" version="1">MSLHSFAGKWSTIKPRLSEWIEEYLLNIGYTEMTPVQASTIPLFRANKDVVVEAVTGSGKTLAFLIPILEKLTNYSNSLKKGDVFALIVAPTRELAIQTHSQLNDIITASPVDLPPPLLLVSDQDSTTTDDRRRFEQQGSQILVGTPGRVDEFIGGNKGVKGKGKGSGRYTNFEMLVLDEADRLLDLGFLPTLRSIVSHLPKQRRTGLFSATMTDQVGNLVAIGLRNPAKVVVKVTSKSSKSEIEERRTPAGLNNTYTVVKQQDKLAKLLKLLQNEVEEGKQKIIVYFPTCASVDYIWQVINKLPKKYLPPSSTTIHSLHGHIPPPKRTTALSSFTNSPSAVLLCTDVAARGIDLPDVDAVVQWEAPTDSRSFSHRVGRTARAGNSGKAILFLSQGSEEGYAEFLRGRKIPLAPHRPIEDAADSKELLEIMRKILLKDRSLHDASIKALTSTVRSYSKHEQVYLFRTYELDIPGLATSFGLLRMPKMPELKGKEIDEKDWQDAEVDWDTYAYANASQEASRQKKLKEAPKREIKPKKEKEAAWSNKKDRHDKRITQKEKKEAKRKFEKAERARLREEEEGNSEEEEEDWKAHVLETREAKKRRKEEKNKGSDEDEMDPGTTFAFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F6</accession>
    <name>I4Y5F6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960770.1">
        <property type="nucleotide sequence ID" value="XM_006960708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F6"/>
    <dbReference type="GeneID" id="18473084"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58881"/>
    <dbReference type="eggNOG" id="ENOG502S90P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106356_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5F6"/>
    <dbReference type="OMA" id="FTIEPHI"/>
    <dbReference type="OrthoDB" id="2506317at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="136" mass="15336" checksum="86390F0AB002B2EB" modified="2012-09-05" version="1">MSNPEDLITLVKSPSVQRPQIPKLPSELHPLPPDISAYFVYPLSLEPYALNLLPSLRQKANLEHQKHLNFLNERKAMIENKKKAEMNRVAPGWNGAWDALEPASVASPTISTNQNQHNRQPSIEEDLVNGLEKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I3</accession>
    <name>I4Y5I3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960722.1">
        <property type="nucleotide sequence ID" value="XM_006960660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I3"/>
    <dbReference type="GeneID" id="18474611"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61572"/>
    <dbReference type="HOGENOM" id="CLU_1732904_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5I3"/>
    <dbReference type="OMA" id="RACIVKL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="16891" checksum="AC32892402FBF20F" modified="2012-09-05" version="1">MLKSTALKLQRVKYTTTVAPLSDSAKRELITLFNQSQNFLNSAEIPNKIDSTLTNSNPGLPHHLTTVKFEKSDSSSNSKPLLRSSRLHFNEDIYRSGFDEFGDRIQWPSPGVHNLSDRERSLRDTLFGTDSDGAPGLEIVEEAEGQLKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5P6</accession>
    <name>I4Y5P6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">The Sh3 domain of Betapix in complex with A high affinity peptide from Pak2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_10046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960646.1">
        <property type="nucleotide sequence ID" value="XM_006960584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5P6"/>
    <dbReference type="STRING" id="671144.I4Y5P6"/>
    <dbReference type="GeneID" id="18470580"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_10046"/>
    <dbReference type="eggNOG" id="KOG2070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186395_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5P6"/>
    <dbReference type="OMA" id="VTHCEAR"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="51" mass="5749" checksum="CB665AEBBD564B1A" modified="2012-09-05" version="1" fragment="single">FVKATYNYQKLDSSSLSFVVGDVIEVLTTLESGWWDGLLGNDRGWFPSNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5V4</accession>
    <name>I4Y5V4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960622.1">
        <property type="nucleotide sequence ID" value="XM_006960560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5V4"/>
    <dbReference type="GeneID" id="18475774"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70686"/>
    <dbReference type="HOGENOM" id="CLU_2016982_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5V4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="123" mass="14428" checksum="764D909C27561D05" modified="2012-09-05" version="1">MVNDIIVATENLRTFISKRDSTSKFNKVYIDVYTSYKLVNIRDKTIEAELDKSRRCYLDKLSTELVTAFGLLPPNKANELLYKSLEQLLAALTDFIKKIYSQQKNSRNKLQKKKFENEWIIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y620</accession>
    <name>I4Y620_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Arginase</fullName>
            <ecNumber evidence="2 12">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 12"/>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960562.1">
        <property type="nucleotide sequence ID" value="XM_006960500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y620"/>
    <dbReference type="FunCoup" id="I4Y620">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y620"/>
    <dbReference type="GeneID" id="18474560"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61487"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="InParanoid" id="I4Y620"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000005">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0835">Urea cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="33260" checksum="657976E428B00D96" modified="2012-09-05" version="1">MTAFKFVKPQVAFVNAPFSHGQPKRGTETGPLQLISSGLAQQVEGLGLTVDAVEDHKGFDILENDTDIGKLKFPRTVSNATRQVYEEVEKHAKAGKLVVNLGGDHSLAMGTISGSLSAHPDACVVWVDAHADLNSPETTETGNLHGCPLSFLLGIAGNIPEFSWIKPLLKPERLVYIGLRDVDDGEKKLLKEHNIKAYSMHEVDKYGIGKVVDMALDHVNPDRSRPVHLSFDVDAMDPSVAPSTGTPVRGGLTFREGHYICEALHETGLLVAVDLMEVNPALENEEAVKQTVSVGCSLIRSALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y637</accession>
    <name>I4Y637_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960579.1">
        <property type="nucleotide sequence ID" value="XM_006960517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y637"/>
    <dbReference type="FunCoup" id="I4Y637">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y637"/>
    <dbReference type="GeneID" id="18474565"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61496"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021251_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y637"/>
    <dbReference type="OMA" id="LPNWGNW"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="312" mass="34313" checksum="69CF1708802402F3" modified="2012-09-05" version="1">MTPSMKDNQCAYFGIFDGHGGPFVSQYLRDHLANLIERISKRDWSLLDYFRVYGNYFPYDKGHSGELTIKERLMLAFLKADKAAITDAQNRAYMCGSTASVLLLQSLDDPPASYAFSGRLQMSTAHCGDTAILLVKAHSGTVERLTDDDHADNIGEAARLKHFRGALVQDSYGESRLLGQIANTRSIGDAKYKSWGVTAEPHTRSSEIDGRNYSLAILVSDGILNTISIQEIADVARSKFAQQLVRGRAAQAAAQAVVDFAIDVGADDNCSALAVPLPGFMTAGKGRDKTRDLRDYRLQLANDPDSVRQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y641</accession>
    <name>I4Y641_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960583.1">
        <property type="nucleotide sequence ID" value="XM_006960521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y641"/>
    <dbReference type="GeneID" id="18474566"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61497"/>
    <dbReference type="eggNOG" id="ENOG502QS59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538844_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y641"/>
    <dbReference type="OMA" id="VWHANGI"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="57264" checksum="462C5E5EB49B2734" modified="2012-09-05" version="1">MSKEEIDDTSHEQHRIDYLAYGLAYFLYKVEQYLPVELDQNPHQQFRYAKLVSNVERLYVNLSTNSVMDGMKQFGNIIMWKNRPLTFLVVTIYLTLVFTDMLLNTIIAGVLIGITSRKVFPPSSSSQIESSKDEQERAREIVDLEAEFGLDVDGNNAPGQREKSMKEAYKAITESHGREIQLVTGDLADFIEKLKNLYLWRKPKATRNFILRAVLPALIGLQFISHAALVRGSLAGLGFVIFIWIPITINYPRYRRMAWNMPEVPTDAQYALSVMRQRVRKNEPLPVLADPLKKETRKKTDAPRNPNNDNTDSTEIIKSPKKGGSKWSRMAASLQRGGKAAERGTDMISQVINGDKGVFIRQAQEVWASRNDEDSERTSEMLSQESDNGSIKSKRHIGLEPSRVAYLPLRSTHFAILKSSPGTLALNSSELRFKPFKGPDVVVQLDALVAVRKNTSLRVGVEVSSGLELSWEEEEDVKVMRLTNVARRDDAFNQLVACSRNVWVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6B1</accession>
    <name>I4Y6B1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_61416</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960428.1">
        <property type="nucleotide sequence ID" value="XM_006960366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6B1"/>
    <dbReference type="STRING" id="671144.I4Y6B1"/>
    <dbReference type="GeneID" id="18474523"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61416"/>
    <dbReference type="eggNOG" id="ENOG502SCC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1138769_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6B1"/>
    <dbReference type="OMA" id="QWQGASQ"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="244" mass="27026" checksum="2A7E24A96BF9C2E7" modified="2012-09-05" version="1">MTTDLQQQSFTLADDTDNALSVDDLTRSQRKAIDLEAEEPNELDREALLQAELDALIKFRQPLEASVEALCVAQEQNHRLAERVEQTSTLLDEYTRILRQQEHTRNLMLNTHWKGATEDVRAVEEKQRELERQQYEAAQAEERRRAEAELAREREAKEAEMRATAAASASNPSRGSVRGRGRVSVSSTRGRGTLSSSVPSVRPQSRIPPPGSRIPSSSANSGRPSASVGASARGRGIVRGSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H2</accession>
    <name>I4Y6H2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_48810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960362.1">
        <property type="nucleotide sequence ID" value="XM_006960300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H2"/>
    <dbReference type="FunCoup" id="I4Y6H2">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6H2"/>
    <dbReference type="GeneID" id="18472467"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48810"/>
    <dbReference type="eggNOG" id="KOG3881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033769_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6H2"/>
    <dbReference type="OMA" id="PRRANIT"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="369" mass="41394" checksum="3E416849207AB07E" modified="2012-09-05" version="1">MEYNRETNKLSTARADSSIQQYEFNSEDKLNLLNEWNEPRFKGGDYYVGLSTLGRGLVAATSSGHWSYKASKAEERYLSLPTNLKDMRVSPNGSTFAYGGLEVDLSIWDAKRALEISENTPTAPKVDSIQGATKKERKKAKDQLLDGEVWRAKNLPPDNLNLRVPIHITSLDYISETNIITGSANGSVRLYDTRASKKPTIVNNDLIKSSSVRYLRRGEHEYNVFVSDNNSNLFNVDIRNLKLINGYKGIGGAINTIAPTPYKEISLSGAMDKYLRLHTSIVPPEILGKNPTTKANIFSKVFVKSTPTVLEWDGVIPVEETKKRVERTPESDESEGELDDVLQDMETVTGEDMKVKRKAEGRRSKKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I4</accession>
    <name>I4Y6I4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_33949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960374.1">
        <property type="nucleotide sequence ID" value="XM_006960312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I4"/>
    <dbReference type="STRING" id="671144.I4Y6I4"/>
    <dbReference type="GeneID" id="18471781"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33949"/>
    <dbReference type="eggNOG" id="ENOG502S4S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057731_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6I4"/>
    <dbReference type="OMA" id="GVIRMRW"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="28553" checksum="FB637C60C7F44DBA" modified="2012-09-05" version="1">MSAAVDETPIEPESAEENVTKDVKPDATVRPYALFLTGEIIGKLSTQQLLAYASEFSEPPPYGMEWIDDHRCVFVWHESQDFRQGWRGLLVDIPETGLPRHGQDHYFDLLPARNVPSTLSKIEPKDDSVQIRVRPATLGDVKRKTQYKNSQWYSSHGRRAGKIGDSPPRPERSRREVSPDRWQNDKADLDAELDGISRGDYRQRSPPRDRSRGRGRGRGRDRDDNRRRQQVNADDLDKELEDYLSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K8</accession>
    <name>I4Y6K8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_48871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960398.1">
        <property type="nucleotide sequence ID" value="XM_006960336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K8"/>
    <dbReference type="FunCoup" id="I4Y6K8">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6K8"/>
    <dbReference type="GeneID" id="18472474"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48871"/>
    <dbReference type="eggNOG" id="KOG1625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014923_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6K8"/>
    <dbReference type="OMA" id="PFLDIEH"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="8">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="266"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="560" mass="62535" checksum="B34BB0511E5B8D2C" modified="2012-09-05" version="1">MNLRNFKLQLQSEAVQNTPVKKPSLNLKKRVQQQSTPLRNSSSPLTPSNYASDSTPKASQSNFVSRKNPGLITNTLNGHLEIAPNNSVFDTRVGLLSAVSLKKYKYRYMFEKLSERSAVLDERIDYFANRVKEFYKGSFEIEIGDPGMMNQSQTICIGRICKETDITKLDEDSIILETSKSLGSGARVPLRFSNECKVRGVPKGSGGIRLFPGRIVGVLGSNRGAGYFGVEEIFTMPPLGTVKTHSQELYDMQHSTESLGSSPMSVIVAAGPYTLDSNLDYEPFDALMTQVERKQPDVVILLGPFVDANHPMIKKGEVDLLTEDLFKMRIGSRLTRALENAKGCTAVLIPSVRDLITPYVVYPQNALPLNNLGLPPRQRCKCVSNPASFHVNEVLFGISNVDNFMHIRKEEFFKPLKEADEEENETNGATLNDNMKNLCSDIIDQQIYYPMFPAPKELSQDVNLDVSHLELANFPNGKTSEDADERVIPDILILPSILKNFAKVVDQTICVNPWPTARGKNSGTFAHLSIHPMSKQQLSNTNQFIHHKINERCRVDIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6L8</accession>
    <name>I4Y6L8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_22114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960407.1">
        <property type="nucleotide sequence ID" value="XM_006960345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6L8"/>
    <dbReference type="FunCoup" id="I4Y6L8">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6L8"/>
    <dbReference type="GeneID" id="18470912"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22114"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y6L8"/>
    <dbReference type="OMA" id="FATIKKY"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="324" mass="36168" checksum="3BA9EEB31AFAB1E5" modified="2012-09-05" version="1">MSNSLDLLKQTGTVVVSDSGDFESIDAYKPQDATTNPSLILAATKQPNYAKLIDVAIDYAKSQQGDLNLKVEHALDRLLVEFGRKILDIIPGRVSTEVDASLSFNKEATKEKAREIIQLYKENGVHKDRVLIKIASTWEGIQAAKDLEAEGIHCNLTLLFGFGQAVACAEAGVTLISPFVGRILDWYKKNKPEGSYDGEKDPGVVSVQKIYNYYKQHGYNTIVMGASFRTTDEIKNLAGCDFLTVAPALLEQLKNSTDKIERKLDPQTAQASEKIEKTSFINDEAKFRWALFEEQMAFDKLHEGIRKFGEDAITLRGELKKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Z7</accession>
    <name>I4Y6Z7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960247.1">
        <property type="nucleotide sequence ID" value="XM_006960185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Z7"/>
    <dbReference type="GeneID" id="18474475"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61347"/>
    <dbReference type="HOGENOM" id="CLU_598798_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Z7"/>
    <dbReference type="OMA" id="ESMAITP"/>
    <dbReference type="OrthoDB" id="3356534at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="457" mass="51213" checksum="1BB5647BF5CFC366" modified="2012-09-05" version="1">MYTNESRYREHFVTPVSYDPKAALAKVDEIIEANKRAFENRMGNGLGLGFEISDYRMKDVKENAPDAQESHALQTNEEPDVSINSNPQERSMSADSVPTLVSDSEESFSTDESLVITPDRHVASTIRPVDKKQRERPIHLTLRTEGGDEEEEAKENLLDGEDLAKYYRSHSRQGTPTSPTPQRRNVKMTKDSQESKPDSNAIYSSFVAARRSKSLDKKATIQRSLSIQTPSKPSTIELTKPIKNTIKEEDEESENLDWLVPLIQHAMPSKRTRPPPIWAQYAKVKGLSTDDNSQASTNVHSVLDRPRPRTSSYAFGSGTVKTDTSRKCSEKTSVVAMKKAQRKPDARDLFGDIRKDEELPFPSSYASLPMGPMPSVDRRSTSSTGVGGSFERLPKDRSVTPSDLIKKRSSMNDDPTSSTATMPLLPESQALRDLENMLVAYTEDEVLMRLSNMFQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y709</accession>
    <name>I4Y709_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">chitin deacetylase</fullName>
            <ecNumber evidence="11">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_61355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="11"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960259.1">
        <property type="nucleotide sequence ID" value="XM_006960197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y709"/>
    <dbReference type="SMR" id="I4Y709"/>
    <dbReference type="STRING" id="671144.I4Y709"/>
    <dbReference type="GeneID" id="18474480"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61355"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120845_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y709"/>
    <dbReference type="OMA" id="DEYMAQH"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="13">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="27497" checksum="F5844D2CFD5563BC" modified="2012-09-05" version="1">MHIMKLEKISVVGGLAVVVLLKMTLLNVQTISRPDMLRAELVLGHQLSVHTWSHPYLTTLTNEELVAELGWTKKIIQEVTGLTPNTMRPPFGDIDNRVREICRQMDLTPIIWTAAEVGGKDFTFDTNDWKIAGGSVSTTKSKETFEKILNSAKDIDNGFIVLQHDLYQQSVELAVAYVLPDAVNRSPKLNLLSVIDCLQKPQTEAYIETSANKTKPYEVGTDQSSAKSIRHSISLAIIATLAISINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y776</accession>
    <name>I4Y776_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine adenosyltransferase II, beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960152.1">
        <property type="nucleotide sequence ID" value="XM_006960090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y776"/>
    <dbReference type="STRING" id="671144.I4Y776"/>
    <dbReference type="GeneID" id="18474446"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61298"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y776"/>
    <dbReference type="OMA" id="RMPLMFG"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="294" mass="32359" checksum="ECA713D786E542FF" modified="2012-09-05" version="1">MVKVLVTGASGLLGRAILDNFSNDGSIQVTGLAYSRSSDKLIKCDLNDEKAIEGVIREQQPDVLIHCAAERRPDVAQNDPAATEKLNVDVSGNLSRLMKNIGGSIIYISTDYVFDGTKPPYTTTDTPNPLNLYGKTKLAGEKAVTQNNDKSVILRVPVLYGRVENTKESAVTILIDAVKEGKAKKMEHYANRFPTNVDNVAIALNALTKNIQKVPQIVHYSSREAYTKYEMACTFAEILGLPSDHLIADTEEPTGDAAVSRPKDCQLSRDSFDKLNLNVDDNLSFKEFFIKFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B2</accession>
    <name>I4Y7B2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960188.1">
        <property type="nucleotide sequence ID" value="XM_006960126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B2"/>
    <dbReference type="GeneID" id="18474456"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61313"/>
    <dbReference type="HOGENOM" id="CLU_2086660_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7B2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="117" mass="13326" checksum="88F224164A61A272" modified="2012-09-05" version="1">MLTIFQIVVAKINESGVDIKTYDSSSIIDLSEHGAGLAAEWAIPFITAANNFGTGLIGIGQHRFDEKRYEGKRDLLDNFVFIQMRRYCLSQRRKDIFGETFLELLESFNALFLESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7F4</accession>
    <name>I4Y7F4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960038.1">
        <property type="nucleotide sequence ID" value="XM_006959976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7F4"/>
    <dbReference type="STRING" id="671144.I4Y7F4"/>
    <dbReference type="GeneID" id="18475065"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65894"/>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020375_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7F4"/>
    <dbReference type="OMA" id="IRVKIHY"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="492"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="583" mass="64924" checksum="A0D76230AEC77D88" modified="2012-09-05" version="1">MSLKDELTIWSQALEAYDREDVAQAVNSFKTIAHTSKIQFNIAMIYDGLAIDKEALKCFLRSSELDPYLAIAHFQAGVSSFKQNCMNAAIHSFEICIECLRGNISIDYAQIGLDYSLHISEVQFNLGVCLISAGRTQLGFNRLRLALDKSEKPEHVIIESVLNNSGRSASLFAVPVGMLFQPPEVKIKNLGVKDYLGRSQLISTSHSYDLSTDFAGFKLLDNNQKRPKTAQDGSNRPSVLLGRSNTTPPIKSDAATIPILRSRTSSRANLTTSAYPKSAVINEDIISEDKSDVDDKDFEINNNFQNQKQTSTKTEMYFTRRQFDQSSAELENNMLNGKVNDYDLSSALHTKRPPPILTLPLHKSNSPLPTPSTSASSEDSEKSFRQAIDEKLNSGKKQLRPAFINRSFSTLRTKSNNLISSKRSSSSIPKQWPSTSEHGTPMAVSPVGPISAPLPGSFVSTGPGTMKRTHSDTDGQLTPPTQELKCSVPNFNIRIKIFLNKDVRGMIISAKETPYEKFRDSVHSKFPHIEPPRLAIKFKDDDDLVTILDDTDWEMAIECAHVEAELKKRSYGTLEIYCSERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7L0</accession>
    <name>I4Y7L0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_40750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960090.1">
        <property type="nucleotide sequence ID" value="XM_006960028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7L0"/>
    <dbReference type="FunCoup" id="I4Y7L0">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7L0"/>
    <dbReference type="GeneID" id="18472189"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40750"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y7L0"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="753"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="990" mass="111061" checksum="645DD9127D4EDCEC" modified="2012-09-05" version="1">MDKLKNSGTIKRATNAFNKDTSKDGAVISQQTNMRGLTQYIADLRACRIRELEEKRINRELAHIRQRFKEGDMTGYQKRKYVAKILFTYILGYKVDIGHMEAVNLISSTRYSEKQMGYLALTLLLHENSELTRLVINSIRKDLDDMNEVNNCLALHAIANIGGMEMAETLSEDVHRSLISPTSTSFVKKKAALTLLRLYRKYPDIVPVREWALRIVSVMDDENLGVSLAVTSLIMTLSQNDPDAFAICYPKAVDRLTKIIIEKKYTGDYLYYKVPSPWLQVKLLRLLQYYPPSEDPAIRLAINNVLNAILLNSQDIPKNVQHANAQNAVLFEAINLSIHLDTDSSIVNAASVLLGKFIMSKETNVRYLGLDTMAHLAACADSLEPIKRHQNTILMALKDKDISVRKRGLDLLFSMCDTINAKPITAELLAYLQNADYGLRGEMTLKIAILTEKFATDYKWYIDTILRLIQIAGEHVGNEVWYRVIQIVTNTESLQQYSAHTVFSFLRQPSCPENLVKVGAYILGEFGHLIADNPGCSPIEQFNIIHLKSNFCSASTRALLLTTYIKWVNLFPEIKDILVNVFDKYRYVLDSELQQRASEYYALATREDGDQLLQIVCDEMPPFPERESALLTSLDRKHGDTQDSRTWIIGGKDANRDRNVVRAKSLNKKAQGGILSRGSVLSPTFTGSTGTMEAQPTGQSGQNDQLLSPQGTQNDDFVAPLPEKTTSGISLSAAPIHIIRNDAIDSAYMHLLYNYEGVLYDSDFLKVVVRSEYQGPLGRLILQIINKVASATLTSFSATIDSSNDEALNITFPQIMSNSKIVGGESVKQSVHVECKDVYSEPPTLRMSYIAGSHQTLALRFPLLLSKFLEPVELSQTDFFERWKQIGGAPREAQIILPINLKLGNIDTQKTNEIFIGNRFSVLQGVDPNPENFVAAAVLHMSTSGKVGCLVRYEPNKDAKLARLTLRTTNEDVSSKLLHVLEMQLTSKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7S2</accession>
    <name>I4Y7S2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_55301</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959944.1">
        <property type="nucleotide sequence ID" value="XM_006959882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7S2"/>
    <dbReference type="FunCoup" id="I4Y7S2">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7S2"/>
    <dbReference type="GeneID" id="18472725"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55301"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7S2"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697794" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="20">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM20014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="421" mass="46825" checksum="92FA8B91BE374F85" modified="2012-09-05" version="1">MSIVSFLATVILIPLSSPHLVRAGLRGRDLLKPYKQLVPESLGIVPACVLIVLLFLFAPISFAQHLRTYGSTLQPQFPHNKLATYLSALLSLQTATLLGFLDDLFDIRWRYKLPIPLIASIPMLVVYFAEGGITDVVMPIPARQYFGKVVHLGPLYYLYMAMLSTFCTNSINILAGINGIEVGQAVVIAMSVVINDLLHLPLPISPNLLMYLPQWVNDWSVTALVGPTTVEQAERHLFSLYFMLPLIGASLALLFHNWYPARVFPGDTFCYFAGMAFAIVGVLAHFSKTLLLFFIPQIFNFVFSTPQLFGLVPCPRHRVPRYIHENGKLQPSYAIFEEVPPSYVSIPLKLLTFVNLVKIEKDREGNIKMATNLTLLNGLLCFFGSMSERDLALCALAVQTGCSVIAFGVRYGLAKFVYDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T8</accession>
    <name>I4Y7T8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_48234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959959.1">
        <property type="nucleotide sequence ID" value="XM_006959897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T8"/>
    <dbReference type="FunCoup" id="I4Y7T8">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7T8"/>
    <dbReference type="GeneID" id="18472446"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48234"/>
    <dbReference type="eggNOG" id="KOG3400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103864_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T8"/>
    <dbReference type="OMA" id="KEDDKGW"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="141" mass="15528" checksum="0F3927FF6DEEC75F" modified="2012-09-05" version="1">MSTSIVFDHLFTVDSIDKDGKKFDRVARVGAISTTPNLNCIIDLPIEIFSLSQNEKFTLALSTSLSSDNGTSGWRPGMGNEGLAADYEYVCFGKVYKFDEGKQEIATAYISFGGLLLAITGHVRYLTDISVGEDIYLLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A5</accession>
    <name>I4Y8A5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959685.1">
        <property type="nucleotide sequence ID" value="XM_006959623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A5"/>
    <dbReference type="FunCoup" id="I4Y8A5">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8A5"/>
    <dbReference type="GeneID" id="18475669"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69968"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8A5"/>
    <dbReference type="OMA" id="RVDWWLE"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="14"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="447" mass="51213" checksum="A8791024F443C3CA" modified="2012-09-05" version="1">MTDSAKFLEWFTTNGGEFSKDIVAIGENVDGMGRGLVAVADIKAQTSLFTIPRDIVLSTRTSSFKEKVGQDVYKQLENDNIGSWTPLIMAMCWEYNQGGSSKWDAYFKILPKQFTSLMFWSKEELSLLKGTTVVDKIGLEDIENEFERVRDIVKQNENVFGDIANYTLDLFKRMGSLILSRSFTVEEWKTEEEREKEEEEEEDEDEEIDLRTSVDDVAMVPMADILNSRTDSVNAHTEYEENCLRMISLQDIKAGDQIFNTYNDPPNADLIRRYGHVDYSPLSQDPDFMGNKNDVVELPADILLELALPDAKESHKERRVEFLLDECGEDSFELTHDDLVPELLKICVLLFTESEAEFKTREKSRKLPKASGFTKGKAEFLIKAIKQRMEQYGSTLEDDISKLDNKDSLPENNFKALVVTVGERRILNKAIEELQTTDYAQKKQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C4</accession>
    <name>I4Y8C4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_20920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959704.1">
        <property type="nucleotide sequence ID" value="XM_006959642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C4"/>
    <dbReference type="STRING" id="671144.I4Y8C4"/>
    <dbReference type="GeneID" id="18470863"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20920"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_13_1"/>
    <dbReference type="InParanoid" id="I4Y8C4"/>
    <dbReference type="OMA" id="HTVGGNK"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="165"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="577" mass="64831" checksum="88A3E65E70EFFA66" modified="2012-09-05" version="1">MSSTSIGSRHSIHATPKVRSLATPVSSRSTTNLNGQTPITAKVRTPRQNQDEVIADEEMMAYIRRSQARRLAAGAKLSELESMLAFPEPVMPTTRMSPREAIALFGSSLSPYEQNEIFNHRDIYFVGQSSKKKLATKERSSSNYGYDDERGDYHIIKHDHLNYRYEIMDTLGKGSFGQVLECLDHKTGHSVAIKIIRNKKRFHHQALVEVKILDRLVDWDPENKHNVIMKTEHFYFRGHLCIATELLSINLYELIKANCFAGFTTALIKRFAAQMLQSLVLMKHHNVIHCDLKPENVLLRHPAKSSIKVIDFGSSCFENEKVYTYIQSRFYRSPEVILGMEYTAAIDMWSFGAILVELYTGYPIFPGENEQEQLACLMEILGIPEKYIIDKSSRRKIFFDSTGAPRPVINSKGRRRRPNSKSIASVLKTDDEQFVDFITRCLTWDPEKRLKPSGALRHPFVTGLPPPPKTTTTKTVRRPSTAQPSSGSTTFKIPNGTAGESKKSMISNPTPLNRHRVSHSHSQSSASSLPGQQSVKSPKIPSLSNTPRILRSKLSSTSTSAPSQSSKVSTISATSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K9</accession>
    <name>I4Y8K9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959558.1">
        <property type="nucleotide sequence ID" value="XM_006959496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K9"/>
    <dbReference type="FunCoup" id="I4Y8K9">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8K9"/>
    <dbReference type="GeneID" id="18474278"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60994"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="InParanoid" id="I4Y8K9"/>
    <dbReference type="OMA" id="CETRPLN"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="345" mass="36963" checksum="04EB0B28E5261643" modified="2012-09-05" version="1">MDITSVEEAYSAIRNMNIRGAPALASLATLSVAQRLHNSSYNNSQELKKEVKQVCDYLYQSRPTAVNLGIALDQLRQAAEIDSDSVDNIKKAVIYQAILVWSEDVERNKQMSDNGAQWLINNLESSGKIEKGGKISILTVCNTGSLATSGYGTAFGMITRLHELGRLERAYYAQTTPYHQGTRLTAFEFTQLGIPSCLVCDTAVGSLISSGIVQAVTVGADRIALNGDTANKIGTMQSAMFAKTFNIPFTVVAPRASVDSNLNDGRSIPIELRAASEAVTVRGIELDSGKQTSVRIAPKEVGATGLHTVYNPGFDITPSQLISAVVLETGVAESKNGSIDVKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y905</accession>
    <name>I4Y905_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959473.1">
        <property type="nucleotide sequence ID" value="XM_006959411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y905"/>
    <dbReference type="FunCoup" id="I4Y905">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y905"/>
    <dbReference type="GeneID" id="18474253"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60923"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370546_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y905"/>
    <dbReference type="OMA" id="HINYDGF"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="681" mass="74517" checksum="D60542EF1FB98534" modified="2012-09-05" version="1">MNLGSIDEKFDNEADVHRTIFIELDKVMSESYVRLLPALLSWPENTAVKYVRAMQTSTNNLGHAFVTFPSQQNALDVLSTVNKVSMPGTSRPFKADWAINAPHLIANPFTSTRSPLHDTRSSNSPEKLVNEFSVFVGDLSPDATEHDLMRAFQHPPNLSNPFTTCTNVKIMTDNATGSSRCFGFVRFSNEDEMIRALDEMQGIPVAGRPIRLSTATPKIKTHQHHHQQQQSHFPLHPTPHVYPLNTEQSLLALDEEAERRTQRQRELQSQTQPDHFSRLANLNSHPSTVPSSTASHIANAAVANASSDPHNTTVFVGGLSSLISEDTLRVFFAPFGAITYVKIPPGKGCGFVQFVRKADAERAIERMQGFPIGGGRIRLSWGRSQSDKAAQAAAQAAQLGLGIGALGQMANLSPAQAMQLSTALQNLGNAGVTNTSVHNAIKHLAAATSGLRGQNGSPTQSPGPSLYNPTLDVFQPQDNRQNFQRQPSPLGQVNFVGNSGLPPSATPSVPSSAGPAGRADPIFYMPPDKANYPDFSTIERERSLFKTFMKPESPVTPGSSASFKSPVTTASIDENFTNLTSPNPTNPMPSPPLKAMPTNTLESYFKSREHNAQQQQHYQTHAQHKEHQVGNLDGFLASEVSGLNIRDHQYINQRATSPLSNNLQTHQIQQNSDRDIKNIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K9</accession>
    <name>I4Y9K9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959186.1">
        <property type="nucleotide sequence ID" value="XM_006959124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K9"/>
    <dbReference type="FunCoup" id="I4Y9K9">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9K9"/>
    <dbReference type="GeneID" id="18475603"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69579"/>
    <dbReference type="eggNOG" id="KOG0359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y9K9"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="542" mass="59064" checksum="CB6BA610E0423339" modified="2012-09-05" version="1">MSGVELINPQAERVRRAQALAVNTAGSIGLANVVKSNLGPRGTIKMLVDGAGNLKMTKDGKVLLSEMQIQNPTAALIARTAVAQDDQCGDGTTSVVLLVGELLKQAERVVQEGVHPRVIAEGFEVAKKEALSFLDDYRQLSNLDRSTLINVAYTSLATKLHSSLAQQLATSVVDAVLTIKPSTTDNQSLLADPIDLHMVEIMKMQHKTDTDTRLVKGLVLDHGARHPDMPKRVENAYILTLNVSLEYEKTEVNSSFFYSSAEQREKLVESERKHVDAKLKKIVEFKNFVCDQQLDDKVKKNFVIINQKGIDPMSLDILAKNGILGLRRAKRRNMERLQLICGGTAQNSVDDLAPEVLGYAGLVYEHTLGEDKFTFVEEVKDPKSVTLLIKGPNQHTINQINDALRDGLRSVKNAVEDNCLIPGAGAFEVALSAHLSGPVKKATKGRAKLGVEAFANAMLVIPKTLAANGGFDIQDAIVGLQEEQSEGHIVGLDLKSGEPFDPIVEGVWDNYRVKRHMLASSSVIAVNILSVDEMLKAGRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9L4</accession>
    <name>I4Y9L4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase Rpb6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_39429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959191.1">
        <property type="nucleotide sequence ID" value="XM_006959129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9L4"/>
    <dbReference type="FunCoup" id="I4Y9L4">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9L4"/>
    <dbReference type="GeneID" id="18472115"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39429"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y9L4"/>
    <dbReference type="OMA" id="TYMTKYE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="10162" checksum="6B3350350DDFEFD7" modified="2012-09-05" version="1">MNGATKATEPNKERVTTPYMTKYERARILGTRALQISMNAPVLVPIEVGESDPLQIAIKELSSNKVPLIVRRYLPDGSFEDWKCQELITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9L6</accession>
    <name>I4Y9L6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_57956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959193.1">
        <property type="nucleotide sequence ID" value="XM_006959131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9L6"/>
    <dbReference type="FunCoup" id="I4Y9L6">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9L6"/>
    <dbReference type="GeneID" id="18472968"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57956"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y9L6"/>
    <dbReference type="OMA" id="PIADNCY"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="36409" checksum="A03AA8AA9981CAE9" modified="2012-09-05" version="1">MEQDLNNPAIRSEDISEDIGTEVFADESISFDENGNKVWLIKIPKFLKERWENVDQDALELGTLRVFNDNSVKVILPNQQYDQLTPDLPREYTLNVHKHTSDNSYVFAEKESEITQEQQNVANSGAFTKINPPINTKLSGKIHHEGSLIPDLNDSYKHIMKQRQQSASQPKRTAKILEPEDTKLASGFNTASRFSSFIKTDKSKQKGAQFERAARMPRNELLDLLFSLFERQKYWNMRDLRSRTQQPLTYLKETLMTIAHLANKGPYHGHWYLQDVYQREHHDKVRQQAEFERQAKEEDVLDNDDIDNNDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M3</accession>
    <name>I4Y9M3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_39448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959200.1">
        <property type="nucleotide sequence ID" value="XM_006959138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M3"/>
    <dbReference type="FunCoup" id="I4Y9M3">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9M3"/>
    <dbReference type="GeneID" id="18472116"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39448"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002027_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y9M3"/>
    <dbReference type="OMA" id="GVNERLW"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="314"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="699" mass="78759" checksum="5209B5C7B986FD4C" modified="2012-09-05" version="1">MNGNDAPFFETAERDTKITSITFKQSNSSMFWGGTKDGSLFEMDSIDGKAYDWSMHQHTSAIIGIWRLNNHMITLDDTGTLKVWLPVTHEDGSTSPTLNSPHKLFKVNADITFVNFLGDKLWLASSASHNSESNTSRSITVRVYDPIGAVYGGTFNLTPNGVMPTSTVQQLAVTSGTIIPSIPSNVYLGHQGGFVSVWSASEYDFRSVTKVSSTQVDALAGVGGYLWAGFHSGKINVLDTNQGSITDWRVVQTWQAHKEKVLSIQVDTALLEFGHLAVITTGADWNINYWDGMLKTAHISTELQNRENSFCSFSPVRLLIVSWNTDASKPSDLVDKGGLFSKSNNSSSNSSFLRNALHSTNSPDIIVFGFQELIDLEDKKLTAKTMLLSKKKADNALSERISHSYRLWYDHLVMEVKRNMPEDSPYVVLHAENLVGLFTCIFIRKERKDHLADVAITTVKTGLKGRYGNKGAIISRFVVDDSSLCFVNCHLAAGQKHTKQRNADLVSILEEKVAFADEPVRSDLSYVNGGDGSSVFDHEMTFLNGDLNYRIDLRREAVIPAISKSNFEYLLHHDQLNKQMETNAQFKLRDFKEPPITYAPTYKYDRKTDVYDTSDKRRIPAWCDRILSRTVHLPRVNNLHYKRYEVNVSDHRPISAAFEIMTKKIDHKKRIDVLTKVEDESASMFSQTIQDEKNYYEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N0</accession>
    <name>I4Y9N0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959206.1">
        <property type="nucleotide sequence ID" value="XM_006959144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N0"/>
    <dbReference type="FunCoup" id="I4Y9N0">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9N0"/>
    <dbReference type="GeneID" id="18474166"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60792"/>
    <dbReference type="eggNOG" id="KOG2202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059852_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9N0"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="216" mass="25469" checksum="EAA415413C24C322" modified="2012-09-05" version="1">MAASRLASIFGTEQDRVNCSFYYKIGACRHGERCSRKHIKPQFSQTIVMPNVYQNPMHRPDNKLDQRGIQVDFDMFFEDLFMELCKFGNLLEMHVCDNVGDHLIGNVYARYEWETEAQAAVDKLNERWYAGRPLHCELSPVTDFREACCRQNDTGDCNRGGFCNFMHLKRPTRSLIRDLQHSQRLERKLRAHEQEDRDRPTNGRHSERSRSRSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N1</accession>
    <name>I4Y9N1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_39464</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959207.1">
        <property type="nucleotide sequence ID" value="XM_006959145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N1"/>
    <dbReference type="FunCoup" id="I4Y9N1">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9N1"/>
    <dbReference type="GeneID" id="18472117"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39464"/>
    <dbReference type="eggNOG" id="KOG0457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018273_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y9N1"/>
    <dbReference type="OMA" id="YNGNHRP"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="415"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="58271" checksum="55BDA0956FAA9062" modified="2012-09-05" version="1">MTVTHKRPQKQQETAKAPDYQPGIRFHCDACARDITQSVRMRCAESSTCDEVDLCPPCFLEGKSIGKHKPWHPYRVIEQHSYPIFTDDWGADEELLLLEGCQLYGLGNWLDVSGHIGSRSKEEVAEHYHSVYLASDDCMPPLDADIKIDPDTFQARKKARFEELGNKPVEIPPPKTKPLTSAPTNHEVGGYMPGRLEFEHELENDAEVLIKDLEFGLVHGLKGDSLPDPRRPGTSSVKLENGDQVSIHDLPPSAAEETLEDEPQADLQLKLALMDIYNSRVDKRLLGKRLIFDRGLLQHKKIQAIERKRPRDERDLVNKLKPFARLQSAQEHERFVDGLVYEMTLRKRINELQEYRRMGVTTFADAEMYEKDKAARAAFKPIPGREQLLQSTNSTNNGRRDSKKGEEFSRESTPSIRTIKKTPASLAVAQSLYLLNEDEQKLCQSVKMLPKPYMVIKEALSREYYKRLGQLKVEDASKLISSIEENKIREIYSFLLKNGYLNSYFCNIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9S9</accession>
    <name>I4Y9S9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_19993</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959172.1">
        <property type="nucleotide sequence ID" value="XM_006959110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9S9"/>
    <dbReference type="FunCoup" id="I4Y9S9">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9S9"/>
    <dbReference type="GeneID" id="18470818"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19993"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030471_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9S9"/>
    <dbReference type="OMA" id="HKCLAQC"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="51287" checksum="E60EBC2E76BB9DF9" modified="2012-09-05" version="1">MRDRYPSFKANASQIELLSSPSDFQKKFREGIENATRSIYISTLYIGEEQHQLIDLLQRRLDERKDLTLTILADYNRCTRQTPAHSSASLMAPLTKRFGGRVRVFLYKPNTKLGALERLIPPRFKEGFGTQHTKIYCFDDNVLLSGANINTSYFTDRQDRYMHISAHPRLTEYMRSFVEQLARFSHKLSCTDDSVQPATYELAWNNDEPAHAYGEKARIEVENFNQSFRCTDEQEGDTTIYPLIQAGLWGVRQEEEAVKYLLEAVNGIPGAKLDITSGYFSLGEAYKRRIINSRVPTSIIAASPHANGFLGSKGVSGRIPEAYTHLESKFFRSCVKYGRATTLSLKEWRKDGWTYHCKGIWIRNEKDDEDCMVTFIGSSNLSGRSSDLDLELSFLMLTESESLGDKLKAELEDLDEHSSSVNQATFDDSTRKVSLFTRFLLWIGIDKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9V0</accession>
    <name>I4Y9V0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959271.1">
        <property type="nucleotide sequence ID" value="XM_006959209.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y9V0">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9V0"/>
    <dbReference type="GeneID" id="18474188"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60824"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y9V0"/>
    <dbReference type="OMA" id="QMLQWIA"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="192"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1265"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1269"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1366" mass="156724" checksum="99402617BCF3F7CA" modified="2012-09-05" version="1">MSSYAGTSQHPNPRARLLLNMPDTPTSLAGKEEDPFAAKFAPNSSEMKGVYSAQQSRSSSMAAESGSEWEDEESVKPKKKKKQQKVKSRSHDDAQQSQSRNEHSEPSRPNTATQVSRRSSFNDNKADKFDKSSKQRWAALKSKIIGNKGPIQSRTGAEVDLVSECMYGMLPAVMLKMALDRDEHQSPRIPVFLHHLKIRVSDSVHPLSNTHAMFRIECQYGDSNLRWTIYRELRDFVSLHTHFRVASVRRTMEGLPEFPKTSLPYFNLLKREVRLKGRELSKSDFARMQRDALQNYLIDLIRSTMFSSSANRICRFFEFSAMTVFLISKGGSQGKAGYLRIMSNNCGRLSAQPSIVSGIKLKKLREPKWWIVRDDYLVCVEDAHSINLYDVFLIDSDFSIERPKRYYRQTANAIRAPFVEGEAFIQQHHPHLPGHHPRQATQPKDSKLDHVKSIDTRPSSSYARENSADEANLNLEQQQINDNVDSDNQLVSSTYKKDTSTHTFYIRNSERRMKLVAKNERQMEQFIQSMMMMKNMTPWSQIHRFDSYAPVRLNVSAQWLVDGRDYYWQLSRAVSLAQESIYIHDWWLSPELQLRRPGQHKWKLSNLLQRKAEEGVKIYVIVYREVSNEFTPIDSNYTKQTLRSLHENIMVQRSPSHLSTGVLYFSHHEKLCVIDQTMAFMGGLDLCFGRWDTPQHICVDEGGENGNDFIWPGKDYSNARVSDFHSLTKPYEDIFDRPTTPRMPWHDVALQLIGQPARDLSRHFIQRWNYLLRTKHHSRELPFLLPPGDLTNAELENQRMKGTLEMQICRSCGPWSIGTPDKVEHSIQNAYVKAIQKSEHFVYIENQFFVTSTIVDTTVIENQIGDALVNRIIRAYRENQTWRACIIVPLLPGYAESVDNPNASSVRLIVDCQNRSICRGAHSIFARLRKEGIDPDDYITFFSLRSWGKFKSGNLTSEILYIHAKTMTVDDRLTIIGSANINERSQRGDRDSEIASIIRDTDMIDSQMAGKPYKVGRFNHSLRVRLMREHLGIDVDDIKSNETFAKGESEAVSHEQPQANGEEGIGQTSGSKYWAPENDHIHTKDDRHYHNKQAPDLEVTEPLDRLQNAIKRSYQELRGEANDDASISKKVEQDEADKVNGDNLITPERPYGSNVERRTRSRGYSTTSSATAFDQRRGRRSTIATTKSGNFTMPFPGPSFDKDSFIDPCSETFFEDIWIASAIYNTEIYRKVFHVTPDDTVTTWGHLKNFNMLADKHKRPIVEDLTNGVERSNSGSSSRYLNGFTNNDEESNGSPKPQRSRRNTRNPSVTAEPGGYTRSEIESMEKMLNQLKGNLVLYPTKFLETEDMSGNFLFNADHLHPLQVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA13</accession>
    <name>I4YA13_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959070.1">
        <property type="nucleotide sequence ID" value="XM_006959008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA13"/>
    <dbReference type="STRING" id="671144.I4YA13"/>
    <dbReference type="GeneID" id="18474115"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60711"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008398_2_0_1"/>
    <dbReference type="InParanoid" id="I4YA13"/>
    <dbReference type="OMA" id="EFSPHVS"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="75603" checksum="71133051126CD544" modified="2012-09-05" version="1">MYLRRWKKSKAPIITHNPRVATIHRISLDLSTLTNPELTPRRLVSASLIHSCLTRSEPFSGKLAKGYILAPGMTPNDASTLELSNDGRVIWGFASGFVGFTQIAKSALQHGSGAASSWGVRGSGLATHQNTSEEFHFGPVTCLSHPSSIASKYNWASSTFVSGGMDGVVKLWSNEPELRCIWSSDIKYLTNSKGEKLSQVDSVTQVSYDSVTCSIAAGYESGTVIVWSNMPIEACVSEGSIQERIENCPVSYVASNSHKQYLPVSKLLLDTQDLNRINLLVHRKRESFFERHDIINKTIYKYGSGPLAELTCFYLNTDLSISSPLATPVPSRTASTDRNLSDALDIGSHYYVNDQMLKHKRAIVAGDASGRTCIWDWDTKSDEIIHPLKIFDGHHAKITSIALTPLLLITGSADGLVIANDPLTGEYVRFFNQNSSTRHLSRFLATNDATVEDESAFAVNGIVANEFAIVASVGNKIIAWKAGGVKDFKTRGKGWRGSNKSVAQKYQYSSDVRDEIRESLEMEEEEGDDIIEPTLPEKALSRLDELGLDESETLDYVMMISREEEEVEKQKDEEMAAILEEIRLNEECETNDNSVVGSSSLQTKPSTSVEQASNHIMSKKEGKKSEYAQPTESLDETYQYDDFAPGDVFPQGIEDADNVNENENQEQTYEAQLKAAIEASLKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAB0</accession>
    <name>I4YAB0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959161.1">
        <property type="nucleotide sequence ID" value="XM_006959099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAB0"/>
    <dbReference type="GeneID" id="18471621"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33099"/>
    <dbReference type="HOGENOM" id="CLU_2623881_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAB0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="78" mass="8539" checksum="45B16594238C682D" modified="2012-09-05" version="1">MVQDKVAKRSLDKSTESDKRSKEGKEDKSVLAILIVGMCKTLLVITMVPFFAITIGVSAYVVLKVVMTVLSDGLEHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF0</accession>
    <name>I4YAF0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rgp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958936.1">
        <property type="nucleotide sequence ID" value="XM_006958874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF0"/>
    <dbReference type="FunCoup" id="I4YAF0">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAF0"/>
    <dbReference type="GeneID" id="18474073"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60649"/>
    <dbReference type="eggNOG" id="KOG4469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005984_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAF0"/>
    <dbReference type="OMA" id="STFDCQI"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="539" mass="59520" checksum="2B513178C0F8F2C3" modified="2012-09-05" version="1">MPSSSTMQDSHSQKLSRNLKTPLLPNHEKILWATAQLNGKVELNNSLIKKKTTQSHKSSQILGGGIIDSKENKKTHHRRSSTLFNFNLSNWFHQANQSNTLSKDKDIANKNTSLSLWETRRAVLIVDKVLAPNEEFVIKFQHQLPSTLPPTYDGKIGKISYQFVLGTNKQNGSARIVNMPLTVLPNVTLDEDHRRFDILKPLIETKEESKVDIGDVKDSSDKTSQDQALCFEKAYRYANKLHSSVNKSTIKRSSSTHSSGYDGPFEHVDSNAKVGEQCRTAIGINSRHSQKVTYEIAKEGLNIGVLSLVKSTFRLGETVLGKISINKPHTVSGRVLKFSATLESHEVANDEHAALNTKHTINATRKVHSEFHEPLTIDFSELGFALDVPSHQSSDFQTSIFEVRWVIKLSFLILSPPIMVEPSPRPSISPGSSTSLNDWSPLPTPTLQPLPRTPFTSSSMASFSTPSSPSLNVSLGNGTYVKAISHLVGVDGVPNSYRPQDRLGGGDGKGKEEVIQCQIPIKILPNSTDYEPDSCTLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAL2</accession>
    <name>I4YAL2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958992.1">
        <property type="nucleotide sequence ID" value="XM_006958930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAL2"/>
    <dbReference type="FunCoup" id="I4YAL2">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAL2"/>
    <dbReference type="GeneID" id="18474092"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60675"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_3_0_1"/>
    <dbReference type="InParanoid" id="I4YAL2"/>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="156"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="434"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="619" mass="70602" checksum="204C3BE36F71E86D" modified="2012-09-05" version="1">MAKTSTNEDLATKLLTMINVSASKSTQPKRIRFDNPELQKTSKKKKLSEDTEKTEKTERTEKKSPTKKKKNAQEEDDDEEGLDTLSSHFGPTPTNLTDELLARVVDHRWDSLPSNGPLGRCTEVGLGASPNENVYISPRFTQAKHNKDLLKLLGSYKDVLSSHLTEAEHAKMRKNLSLHIHNHLFRTRRRVLKNNEKLAHFHADDENKGKEAPECTDQGFTRPKVLILTPFRHNALEWLKDLIDNAPTSQTDNKGRLFQEFSLPKGAIDKIASSPPGTYPPDHVSTFVGNIDDNFKLGVKLTRKSFKPYAEFYSSDIILASPLGLKLAMEKSKDTDYLSSIEIVVGDKLDVITMQNWQHLTEIFENLNNIPKEGHGCDFARVKPWYLDNKARYLRQSVLMAGYETPEMRNLFNKHCNNVDGKIRTETRFNGVLGDVAEGVKSSFYRFDADNLLDEPDARFAYFKEKTLPSLKKSAVSSSSTIIFVSSYFDFVRLRNYLKASDVKFAGLSEYSTNKEISRVRTAFFKNEVNFLLVSERFHFFRRYRLRGGLTFLFYSLPDHAVFYPEFVNMGIDNNVEASDISAISLYSRADVLKLQRIVGTTDAKMMVKQGTDDRFSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAU9</accession>
    <name>I4YAU9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_54699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958773.1">
        <property type="nucleotide sequence ID" value="XM_006958711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAU9"/>
    <dbReference type="FunCoup" id="I4YAU9">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAU9"/>
    <dbReference type="GeneID" id="18472684"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54699"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028734_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAU9"/>
    <dbReference type="OMA" id="CYIAEQQ"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="323"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="643" mass="70431" checksum="9735AF0DC869E600" modified="2012-09-05" version="1">MTAVNAKFPVPLESFKKLTLDYKNPQLSSQQRADLLHNINIFRDAIVAFTATGSARGVSGHTGGPFDTAPEVCILLAFINANPEKFVDTFFDEAGHRVATQYLLSTLDGHISPEHLLNYREAHSKLPGHPELGLSDGVKFSSGRLGHMWAMINGVAMANRSKNVILLGSDGSQQEGNDAEAARLAVAQNLNVKVFVDDNDVTISGHPSQYLKGFNTAKTLEGHGLKVFRTEGENIDKLYASMCEIISYDGPAAVVASRKIAPEVEGIEGESHAHDVIPVAVAKKYLTKRGYSEDQLSFYDQIKPQKYQYEYTGVSADKGANRVIFGEAVNLVLDKLSKEEAQKRVMVIDSDLEGSTGLKGIHAAHPEVFIPSGVMERGNFSAAAGFGFGGNGERQGVFSTFSAFLEMCLSEITMARLNYCNFLCHFSHSGVDEMADNTCHFGLNHFFADNGLLDTAQTNLYFPADGEQMKAVVQKVFFDKGPKFVFSTRAKVPYIYKEGTETKLFGEGYDFVPGKEEVIRKGSAGYVISYGDMLYRSLDAVERLRKEGLDVGLINKPTLNVVDEETIKEYGKTGFVFVVESISQKNGLGSRLGTQLLQRGFHTKYDFMGAHTEGCGGVEFQIPHQGLDSPSIQARIKKVAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB02</accession>
    <name>I4YB02_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_38904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958818.1">
        <property type="nucleotide sequence ID" value="XM_006958756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB02"/>
    <dbReference type="FunCoup" id="I4YB02">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB02"/>
    <dbReference type="GeneID" id="18472086"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38904"/>
    <dbReference type="eggNOG" id="KOG1063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006430_2_0_1"/>
    <dbReference type="InParanoid" id="I4YB02"/>
    <dbReference type="OMA" id="ENFRHIS"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="13">
        <location>
            <begin position="398"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="787" mass="88344" checksum="C229269FCF96856D" modified="2012-09-05" version="1">MSYRKIYTSIGCNRSSNAADVDSQGLIAFGAGSYLSIWNPNDKLSNGVKQTYSGHKGDVRIVKYLQSGRESKDIISGCTSGQLILWKNNNEEYENVVTVDAHEKSISAVGTLRAPIVDRTGYLVASAGSESSLKIWNIVDKEANLLQSIDLNGKFVLDITLSLLPHSKTPVMALSLTNNRIEIWTMHNDSFVKSLSLEGHEDWVRALTFGTFSTEHGDNLVLASGSQDGYIRLWNISTHSTQNRENKENVHIDKTTLNSALLDDFERKMEEADANSSSLSTKSHVFTDHNDNKQYKLNFEALLLGHDSWITGLHWHPIQWESENKYTQPQYLLSASADKSMILWSPQSDGLWMNERRFGEFGTGGLGFFGGLFSKDGKEVFAHGLNGSFHRWAHSPQDGLWQPKLAITGHASPVKDVQWDPDNQFFMSASTDQTTRLHGAWKRNEVETWHELNRPQSHGYDIQAIAFIDGDSTKLATAADEKIVRTFDAPKGWIRSAKKLGVLSNDIDEESRPLGASLPPQSLSNRLVKNDEHPEEQDKDWSLSHTYGNQMEKPPVEEQLVTSLWPESNKLFGHGYELFSIAAAHHSSLLATACKSQSAKHAVVRITDAIKGVHYGNPLEGHALTVTRIQFSPDDQLILSVSRDRTWRLFEKSSETEEYLPVAADKSHGRIIWDCCFSDCGRVFATASRDKTVRVWSRTGFDNKNWKTISTLKFDEPATAVSMSRNNLVIGLESGLIEVYTKGEENFDNWTKTHIIKEHIGFINRVSIKQNRLLSCSEDNKITLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB22</accession>
    <name>I4YB22_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">20S proteasome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958837.1">
        <property type="nucleotide sequence ID" value="XM_006958775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB22"/>
    <dbReference type="FunCoup" id="I4YB22">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB22"/>
    <dbReference type="GeneID" id="18474054"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60610"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="I4YB22"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="256" mass="27956" checksum="6EFB8EB35EF5CF4F" modified="2012-09-05" version="1">MSDSYSFSLTTFSPSGQLKQVDHALAAVAQGTTSLGVKASNGVVIATEKKQPSPLVDDSMLEKVALICPTIGCVYSGMGPDYRQLVTAARKSAQAYWKMYNEYPPTRVMVSEIATIMQGATQKGGMRPYGCSLLVAGYDKTRGSTLYQVDPSGSYWAWKASAMGKNMVNAKTFLEKRYNDEISLEDAIHTSLLTLKEGFEGQMTEKTVDIGIIQIPNEWDTKNPPDALAGDKAGHLPGMPVFRKLTEEEIKDHLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB40</accession>
    <name>I4YB40_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_57755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958855.1">
        <property type="nucleotide sequence ID" value="XM_006958793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB40"/>
    <dbReference type="FunCoup" id="I4YB40">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB40"/>
    <dbReference type="GeneID" id="18472949"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57755"/>
    <dbReference type="eggNOG" id="KOG2143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005116_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB40"/>
    <dbReference type="OMA" id="ECRVESM"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="550"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="732"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="793" mass="92684" checksum="5E53B225423BC210" modified="2012-09-05" version="1">MDRYVELIDTSISTVLHNESYLFTEQELEYFKLYTSLYYNHKLFLSRLLNRQPQNWHKLSKFDFGFDVEEIINDLVIHQYDNSLDNDLALAIIQSLDLARIEGDQDAWKDLNFVQSNEYLELPTTSVEYVLSICNNQDLITISRKFNCLPKQQTRKNMTDAILNTSTTQSTLTSNGKLSFNTSGNLLNQSLSLKQSIIKQMDKVIRINPPIHNLFNRLAFVYSRQSTLFSPPHHLLSTFNKRYYPQPEHKRTIAFASRATLIEFIHALNLEAEFDQALEEKDYEEAQRVAESILDRWRDMIHSNIIIKNWRARYSAGHVYTRLVHKLSGIYSRNKRYEEEVGLLRELLAQRVWRSSRRGAWYSRLALVLMTHFKNTEKLSYYLNEALNVCAEALMDQDTHEIYKPDLYRRITRLEKSKVFNLSQEDRTPVLKLRNPNKKFVYADRDYSTMTTHSFWKPFFPVVVQDGEDPVDTLRVEDIALQAYNIEGWKGLHTEGRIIRTIFVLALWDIIFEPIEGAFETPFQTAPLDLSDGDFYQHRRESIEKRLEEIQEIGAKDLVSERYDAEIEKRTWAVAVNWDYEREDLVNLTECFEGRCLAQIFRVLCQDWDNRTGGMPDLILWRMDSHTVKFAEVKGPGDTLSETQKVWNDVLLSTECEVDVCHVVASNVQDEKDQIVTKKFQKSKSDSKDSLLPSIVRMRRSKSDQNVNQKTIMHRSISEQPLTAKTNEILRRDMSMPPPDIGRTRTPSELNIDIPKTRSMRRKSSGISTASKATKKPRVRSESSIENYFNKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB80</accession>
    <name>I4YB80_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase expression protein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958894.1">
        <property type="nucleotide sequence ID" value="XM_006958832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB80"/>
    <dbReference type="GeneID" id="18472952"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57782"/>
    <dbReference type="HOGENOM" id="CLU_615691_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB80"/>
    <dbReference type="OrthoDB" id="10526818at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="52629" checksum="86BDC13914CA12D0" modified="2012-09-05" version="1">MLRNIFKNINYSPSSSPYLHQLSELLNKRDFYNLIKNFKHCDLPLHSLQQLELSSLNSQEKRRLLKLTSNIRPISRATLNLTTLLFNQLTNKNDKDIANLIHQYSHIKPYNMEEPLRLYRMSESDKHSLLALLEFAYKSNNDRLYFQLYNTIKIHQLEFNFKVVRIHIFKSHDKLQYINKLLRYMNNDYFDDGQKRHLWFKIIKLFCLDEISSYGNSLHNSISILDEWQRAYFDIPSAITKDTTHPIFSLSNYSGFHKINRPLSPAYLIIMQKAADLGDLTTCFKLLGDLVDVNSLTGKFTTNAIKQAQLEKHDNRFNKLIIPLNAYLILYQACKNTSQRSISQRTDLLYKVHNYFIQQESFGIIKGDNVVPQDNRGNQVPSPNQILMILTTFLTITQNRQTVLEVWQQLRVKFRKQSSGWVGWNKVERYHRIRRLLYECKEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB86</accession>
    <name>I4YB86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">WALSEDRAFT_7029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958571.1">
        <property type="nucleotide sequence ID" value="XM_006958509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB86"/>
    <dbReference type="FunCoup" id="I4YB86">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB86"/>
    <dbReference type="GeneID" id="18475708"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7029"/>
    <dbReference type="eggNOG" id="KOG1784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_8_0_1"/>
    <dbReference type="InParanoid" id="I4YB86"/>
    <dbReference type="OMA" id="AACDQTT"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="8843" checksum="92C7CC901FCAEC50" modified="2012-09-05" version="1" fragment="single">KLLLITTDGRCLIGHLQGYDNNSNIILSQSFERVFSSDQGVQTVDLGLYLIKGDNLVCASEIDTTIDDQNEWSNVKADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBF7</accession>
    <name>I4YBF7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958652.1">
        <property type="nucleotide sequence ID" value="XM_006958590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBF7"/>
    <dbReference type="GeneID" id="18475536"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69160"/>
    <dbReference type="HOGENOM" id="CLU_2063302_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBF7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="119" mass="14148" checksum="4DF6E61B9E063E8C" modified="2012-09-05" version="1">MSSVKLIERIKNYDKYKNLNLKDKIKLLTPQLNTKLTGYMLFLKSTKLDVKSASEKWKALSKEQKDEINKKALEYPPINNREDIPRSYYNQIRQIQLDLAEEWKATDEGCRESMEESFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBT2</accession>
    <name>I4YBT2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958455.1">
        <property type="nucleotide sequence ID" value="XM_006958393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBT2"/>
    <dbReference type="FunCoup" id="I4YBT2">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBT2"/>
    <dbReference type="GeneID" id="18473938"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60424"/>
    <dbReference type="eggNOG" id="KOG1442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044894_0_1_1"/>
    <dbReference type="InParanoid" id="I4YBT2"/>
    <dbReference type="OMA" id="WWTSNIV"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="39122" checksum="021054CE74E58671" modified="2012-09-05" version="1">MEHTRSAVTAVVIFYLTAAIIMVLVNKAVLNVENTPPLFFLFVQLAIAVILLLASHLFRLVRLPKIERNVARGLWKLIMINVAGLSFNNYCLKYIDASFYQVARGLVLPITVAISYIFLRTRPSPWILGACVIICLGFFISVHPGEADLNATGIVFGLLSSLTTAAHAVIIKTSLPVVGGSTIDLAYYVNLFSSILFIPLSILVGEIPTIYALFFETDSNDMITFAIGALITGVVGFLICIAGFLSIKVTSPITHMVSSAVRSALMAILGVVFFHDNLTTEKIISIIVIVIGSVFYTWIKDKENKPAMTYNNEEYEQVEQQPLETIHIDSDTRRNSEDILFEAPPEYSEQDAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ4</accession>
    <name>I4YBZ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958515.1">
        <property type="nucleotide sequence ID" value="XM_006958453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBZ4"/>
    <dbReference type="STRING" id="671144.I4YBZ4"/>
    <dbReference type="GeneID" id="18473958"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60460"/>
    <dbReference type="HOGENOM" id="CLU_687367_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBZ4"/>
    <dbReference type="OMA" id="VHTTAYV"/>
    <dbReference type="OrthoDB" id="3364069at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="401" mass="44644" checksum="1D84E8279AE5EBE9" modified="2012-09-05" version="1">MTAILGKFMGRGIDIASNTAKFAYNQIIQSDEQEQEQQPLAENSSVHYGSFDAASASASRTDTIKANNNKVAHSNVHTDEAPSGSANDVDFSHRPAIAIDESEELMNVKYSTLLWLHAVTPATLIIHFTIIITLILKEFPKSEDPFSLKIHFNVIYIAIASWVLANALKQPIFRLINDIIPSNTSKDLVNVLVTIAHTLLQDLIRWQSLLIAVPALKEVKGDHNDQSFTSLSWFIVGWLGVLLGVSTYQQFINLSLYKDFLPTDKTLLPMTSDLSDYSTETASTSSQDQTNLGSQLTLLENIRDRRTLSDLYGQPFPNIPLPGLLFPLWRLDTLLLSSGIMLILGAYPIWSSYFFVTLINLSISLMWQLLLPKLGLGGLTWISFMFATITFFVGLNQFGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC32</accession>
    <name>I4YC32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_69087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958551.1">
        <property type="nucleotide sequence ID" value="XM_006958489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC32"/>
    <dbReference type="STRING" id="671144.I4YC32"/>
    <dbReference type="GeneID" id="18475524"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69087"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="InParanoid" id="I4YC32"/>
    <dbReference type="OMA" id="WIKINLA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="15293" checksum="07E7CB93294110F2" modified="2012-09-05" version="1">MSSFGGKQSGKSSNDDSKKRSRSHRAGLIFPVGRIERNLREGRYADRIGGGAAVYLAAVLEYLTAEVLELAGNACVDNRKQRIVPRHLQLAIRNDEEIDKLLKNVDIFQGGTIPHIEPALLVENKKSKKSNDISEDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC47</accession>
    <name>I4YC47_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_32698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958561.1">
        <property type="nucleotide sequence ID" value="XM_006958499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC47"/>
    <dbReference type="GeneID" id="18471543"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32698"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="I4YC47"/>
    <dbReference type="OMA" id="WWRIVDE"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="487" mass="53661" checksum="1BF33C4F80BA93F3" modified="2012-09-05" version="1">MTKDCSKLGDNDSNLNEAVDSKTAEAEYDRSILAEEKRVLRKIDLRILSLTALAYLLNLIDRTNLANAKIMNTDTDSSMVEQLDLHGNRYGNVITAFYCAFIVAEIPSNLIMKKMRPSLHISRIVVGYGIVTCCSAAVQSFEGLLISRFFLGIAQAGFYPGILYYFSLWYNDDERAFRFAFFVSFSSLSTAFSGLLATACSYLNGLGHPALAGFRWLFILEGIPTIILGVCIFFMLPDYPESAKFLTPDERTIATKRLGDSVVNNEEEFKMSSVWGVLKQWDFWFIAIMWMLLAHGTAAFFFFAPTIINDLDASFQGVKAQLLSVPPSILACLMTIACGFLSDRVKNRPLFIIIGVAFVTVGYLILAVDKNVLVGRMAAVFLIALANVAIIPVAAYRVSIQSMRGADSTAIGFASSATVAISNISGITAPLVFDSGMRFDYICYTIMSFFLTAGIQAMVCWFWYGPGVTTVNKQQSDKAADKEGNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC56</accession>
    <name>I4YC56_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958249.1">
        <property type="nucleotide sequence ID" value="XM_006958187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC56"/>
    <dbReference type="GeneID" id="18473878"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60310"/>
    <dbReference type="HOGENOM" id="CLU_316918_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC56"/>
    <dbReference type="OMA" id="SKEHATH"/>
    <dbReference type="OrthoDB" id="3363222at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="920" mass="102958" checksum="BCB4359240EB8A6C" modified="2012-09-05" version="1">MHNNGTPATQSINSSHTPESNEVVDSKIAPTSDDHDQSSLILNSTFSSFNDGNNSFDPSQFLNSYTKDDSYSSFELDKSVLSPSSSKRDFNNTSLMAIGPSSSSQKFVERNLDQNEEVVSNGTKDGDLLCDEILFGEENNEKNNEKKNNEEDDQIDKHEVIENDHGDKHMSKAQRERSKIFSSLDAVKKHMSIDSFNDDDDMKDSSETFLDTLSNFSSPPPLLDLRPPSYHEDQFNEYECEQNKPQESLTKKPEDHFSDIIPTSSHPSQDSFNKLITSEIFVDAKSDVESDKSKQVEEDVGHEHELKKDSESIIRDSMSIYDEDEMSALQQKIEAMAQKLEEMRQSELPEPLQPSSSKEALPPSFSFQLDPEEHPELQDDVEFIEEEPLPQDIALPEVQPDEIALPESPVDDTDSSEKGEIPRTRSFVGHHAKTSSVNGSIEEHIQTSSSFHVTNASQSSRSSQEEEEEDNRIIKISPESRKNLQTQLRRLSKEPPKTVIPSEAPKPKPKPAQASPKKIEMSASRTSFKDWMPTPLSPKITEEVEPTDESAKELGDVQKRPGLRESDLNVDREEPKMIHPPRYSSYKASGMRPLQGQLQEKKQNDRRMRDTWLKPPEGLSPTPRTTFDKSRRISQQPIDNRTLPKRYSSKAAKSNISFQSSIENEFDSIISDPTGDKRRSELENQQQKAKAAMEAVWKAARSSSVPPVEQYAISSKQRKSLILPQKKLSANLPYSAPAIKTSFASGLEGVRSRDSQPGVPALPSMRSFRQSIETPQYNPRLSDQRIKTTVEHSFGTPSKSTQSLPKSRKSRPIRLDQLGTPQSKSYSHVNAIPISTPPLTPGTASTISGYDNIMTPRSFTHKPNVSASSMDSMSAQSTSSDNHQSYGVQSFKKNNLNAPFLQHSSSAYSLKQDSGIGYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC67</accession>
    <name>I4YC67_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958258.1">
        <property type="nucleotide sequence ID" value="XM_006958196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC67"/>
    <dbReference type="STRING" id="671144.I4YC67"/>
    <dbReference type="GeneID" id="18472908"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57378"/>
    <dbReference type="eggNOG" id="ENOG502QUSF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070652_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC67"/>
    <dbReference type="OMA" id="FGDYEWN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33242" checksum="07FBF02E4AF42E28" modified="2012-09-05" version="1">MKIAIDFDDVISSTNRAVCQWHNRVYDTEWTIDDFHYYHYWKNPGWGNAQETFKKVTAFYNDNNGLNATQLVTGAKEALLKLKSAGHDLIIVTARNDNQREMTRNWLDHHLEGLFDKLYFTGQFTRDGDLEAENEDNEGIPTKNDQTHLSKADIIDRIGAHLLVDDSIENAFGCANHVRKNGVLAGKPIRTLLLSPIPPSDGIPIWHYPWNVELSKQDTEEDALSYDERKKRGLPTGESRQPTNLPSTIKRVTSWEDIIRKIDEYDTHLHSNAATIEASERAHPHSIQVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCA7</accession>
    <name>I4YCA7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958295.1">
        <property type="nucleotide sequence ID" value="XM_006958233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCA7"/>
    <dbReference type="STRING" id="671144.I4YCA7"/>
    <dbReference type="GeneID" id="18471502"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32513"/>
    <dbReference type="eggNOG" id="ENOG502S6Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546540_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCA7"/>
    <dbReference type="OMA" id="HSAHTHN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="499" mass="57391" checksum="3DAF13A49F56A5F4" modified="2012-09-05" version="1">MREGTVKQPLRAKYISHQLEEGHWVSAYAPDDVIRVRGRKPYHNWGDRAPWPTCYSLQAIEMDQMWHNTLKSYRGGQNIMRVPLNSSQSAGRPPDRPFRVLDIGCGTGTWCLEMSQIWKDAEIWGMDLVPIQPNPEYFRPDYTVADRVNWLIASFLDKWPFEDQSFDFIHMRFVSLGIPEVQFYHVFDEAFRVLKPEGHLEIYERTYQFAAGHTPIPISNPEMAPPKEKHSYTELERLYEEVLTAHTINSSPLSIIASAIVLYDAKNIVQSPVIRGTFPALSFKPERTSDYHDPDYEPSIKKSNVEQFMNTVTTTIESLNPYERDYRFRMILQSLSTMISESSDWLWDEYLTKVVGLSEEHGLFKGLNNVTMSRSNEENSNSGVPNGTPIQSRRNSLSTNVVLNAPPPAETNIPIAWSNKDKFDAEVKEWSSDLNRRASPDKFLELIFGWGDGREEDFCPGGRKLVGAKTWSNERKLECESADDKLGIWQMCGFRIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCB2</accession>
    <name>I4YCB2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958299.1">
        <property type="nucleotide sequence ID" value="XM_006958237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCB2"/>
    <dbReference type="FunCoup" id="I4YCB2">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCB2"/>
    <dbReference type="GeneID" id="18471504"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32518"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040577_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCB2"/>
    <dbReference type="OMA" id="WRQIYKG"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="447" mass="49142" checksum="39267E065AF3BA79" modified="2012-09-05" version="1">MDWIQKITNQVQDLTPYDVKSYIEKAKNIAMNVPEMEAKVNEATNDDPWGASSTLMQQIAQGTFNFQEFNEILPTIYRRFMEMEARQWRQIYKALQLLEYLVKHGSERVVDDARSHISTIKMLRNFHYIDEKGKDQGINVRNRAMEIVNLLSDVEKIRAERRKAKANRAKYVGVGNDQLSGVSFNMSGSRYGGFGSESLNNYSNHAASYSGSRGFSDADNNKEEYEEYDAGDDDDRAEDYHVNTPGSSTTPVSKPQKKEPEVDLFDFGEDETSVAAPAQAPSAPTPISSKPAQATKQTTSEFDDFDDFQSAPVVAPASATQNIPAIQAPNPNANMLSSIPSTTLPVTGLNSIPQPSAPTVSPVANNPATMPNRSNASNQASQAPKDPFSGFDDLWKSSKTTKTENTAKPSMASLAQQKTSDSLWNAPSGTSKPQASQNNSNNDDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCB7</accession>
    <name>I4YCB7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_68877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958304.1">
        <property type="nucleotide sequence ID" value="XM_006958242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCB7"/>
    <dbReference type="STRING" id="671144.I4YCB7"/>
    <dbReference type="GeneID" id="18475482"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68877"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="I4YCB7"/>
    <dbReference type="OMA" id="SAMNFLC"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698782" evidence="9">
        <location>
            <begin position="26"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="610" mass="67855" checksum="10A223CD851AE3A6" modified="2012-09-05" version="1">MKFKLYTMKFELCTLLAGIVLSAEAINPDYIVIGGGTTGLALATRLSDKIDSNILVLEAGNSGLGEKIIDLPFGKSPIGSIYDWNYTTEAQINFGLQPVTLPRGRVLGGTSALNGLGWDRPHSREIDAWGNLGNDGWSFNDLLHYMKKSESYRIPPQDILQEYHIESQDQLNQTAIGNDGPLQATISNNVPDYAKRWLPAFEEIGLDVNHSPFDGDNSGASINPSSVNYQNFTRSYSASAYYLPLSYRKNLDVITGAQVVKLIVSDDKITGVVYNKDGENITVSANKEVILSAGAIGTPQILELSGIGRKDILEQNGIEVQIELEGVGENFQDHTAISTIWKLKPGFHSNDRFKYDKEFLQAELQKFEEGDYTSALANVGACLAYVNLDALFSKEEKEWYISGIQEWIDAQQNSTYVPLYKEQLKFVETNAIEHLVANSFVSYNKDRQPESNTSYISVEAAVQHPFSRGSIHIQTSDPYSHPLLLANYFEVESDRLIQTRGLQHIRKLMKTEAMQEIALEEVYPGENVTTDEDLEEYWKTAIRSEHHLIGTASMMPKELNGVVDDELRVYGLSNLRIADASIIPLHVSAHIQATLYGIAEKAADLILNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCB9</accession>
    <name>I4YCB9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958306.1">
        <property type="nucleotide sequence ID" value="XM_006958244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCB9"/>
    <dbReference type="FunCoup" id="I4YCB9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCB9"/>
    <dbReference type="GeneID" id="18473901"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60343"/>
    <dbReference type="eggNOG" id="ENOG502QWR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016860_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCB9"/>
    <dbReference type="OMA" id="ENELHAD"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="422"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="708" mass="78210" checksum="E9E1A970C2792422" modified="2012-09-05" version="1">MGKSQTKKRTARHNPIRVPDTHQKSSNTNHTQVIPVLEKFKSANASERVWACAATTNLIANDPSTRRLLQSKGVITLLIERLSDNEPDVINESTGSLRNLCIDGGPEICAEMFNKNVLAPLKTHITNIVSIVERIVQGEQPSDHDEISWRRIIWTWIENIVTIFWCLSETSNKAFKAVNDLSLPPFLVAFLKKDLRKVTPLSTTIAASQCLFILSEDNASFKKHFHDNPGDCTALVDIISDPFEKADQVKATLSKILSCGIIRNISPLPAVVPAAAVANDSNTILPILFSCLNADLNALSNESESLAANLPAITSKQNNNTTDHKSNEEKRLDEIELVMITLQSSLDVLTGYCSQIPEGDFELNDTEENEAEEMEEEMQEDIDAIIEGDSQAQDNENEMNEVKPIATTSIIPSSLLTLFNPEVELHNKLIKLAYPTSMSLLRSSISAISPHSPTTAHLSVVHLRALEALQNLLLSLARYAPSPSSPTSEEEAEAWSSLKQQLNPTLSQLWAGLFEIGQAIEPCEVNNFTIRTQSARFGCIENLVGCMLGVSKVLGEDLQLQSSEITALINMYNVSTSGALKSKVVGTLGGLARRQDKIEDNRIIGNFLIDLLNKLPQVASQATDESTTAEVAIAILNELFDIYADENSGYDVPVFRNDQFLNKLRAVVPLVRTCARSVDRKFNPELRATIDEAYQNFLSFIRYRQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCF4</accession>
    <name>I4YCF4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_68905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958340.1">
        <property type="nucleotide sequence ID" value="XM_006958278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCF4"/>
    <dbReference type="FunCoup" id="I4YCF4">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCF4"/>
    <dbReference type="GeneID" id="18475488"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68905"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCF4"/>
    <dbReference type="OMA" id="NKITIMM"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="55311" checksum="95BDE302F2403E99" modified="2012-09-05" version="1">MTSKNVIAQSLKQPKSISIIGGGISGLSAAYYASKAFPATKVHLFEASDRLGGWINSERINLGNYGTALIESGPRTLRPNGVSGALVLDLIDKLGLESSLLSASKSSPAAKNRFIYHPDRLNQLPSSLASIPSALLKYKTLRAIPAAILNDIKTPAHKREENEDESVDAFFRRRFGDKIADNIASAVIHGIYATDSRDLSLRTAFPLLYKLEQRAGSVVKGLLKGVGKDKKEEALELAILDGISPSLRATMQTASIFSFKNGISEIVQTLESALHKNNNVEIYKSSPVKAITQQPNKDFVIDTQNGLSLESSHLISSIPAKQLSLQKLKLSIPVLKSPDVAVVTLVYPQTELPITGFGYLIPRSTPRQKNPHGVLGVVLDSDAMPKQDPKPITKLTVMLGGPYGLKSFDDDHLKNMAIETAVNQLSDNLHTPIASKVSVARSCIPTYPPGYQSTLQELHDSLSTDYDSRFAVIGSSFTGISVGDCVRSGWETIESYKAFGKATGLERWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCK7</accession>
    <name>I4YCK7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_18515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958245.1">
        <property type="nucleotide sequence ID" value="XM_006958183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCK7"/>
    <dbReference type="FunCoup" id="I4YCK7">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCK7"/>
    <dbReference type="GeneID" id="18470773"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18515"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_1_1"/>
    <dbReference type="InParanoid" id="I4YCK7"/>
    <dbReference type="OMA" id="CKCHIRE"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="490" mass="54777" checksum="14AFD3E7D171916A" modified="2012-09-05" version="1">MRPADVNPTANNHVNIHKKHHLYDINKPTNTITLSSNHPLVEKRSAGTPTRHSKNSDFTFDSLLLPPARTCSLYDSHITKLIHSSMAGYNSTVFAYGQTGSGKTHTLTGTEDEPGIIPLAVEQVFEEIYDDPTREFLLRVRYLEIYNEKLRDLLGPATQNEELRVREDKSGNTFVENLTEVLVTTPQEVLALKDQGDMNRHVGATDWNDRSSRSHCVFQIVVESSERQSNLTKHSVSRKSTLNLIDLAGSEKATTDTSRRLEGSNINKSLLALSTVISEIVKTPKPTHIPFRNSKLTYLLKPSLSGDARVGVVCTIADGMEHHNATLDTLKFARTIKKVKIQAKRGDILDGTKDALLQQHITQIKILQKEVASLESNKYEEIRHAIAEERAANDEKVFYQNNQIDQLKKELDDARKLVLNSTSIDGEDISHRRQSQLRHGQSRRLSDMGLGVSAPGFSVPQSKRRVLSTGIPVSTDENVGYLCETCQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCM9</accession>
    <name>I4YCM9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958404.1">
        <property type="nucleotide sequence ID" value="XM_006958342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCM9"/>
    <dbReference type="GeneID" id="18473926"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60393"/>
    <dbReference type="HOGENOM" id="CLU_1215604_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCM9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697697" evidence="2">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="25891" checksum="C62B3F50784E03B2" modified="2012-09-05" version="1">MFVKLSGLFLVLKAVPAVSEEFVHFKWSDYHALGEQTYGVNALKESEEESDFPQASPPNESLDFYWKKIPGSKEGVHSEMFAYDPLPLDLFPNEAWNRSMGAQYHYEDSQLSKRQGGPICQHLSVCENSPAVSNFQELFDRLDPYTCDNIKESSKNWILEKWPYLARATVINIAFAIVGGVTTFYITQNASKDNKPSYTCNVSKDDACGICEAQEFYHRIDGKIEEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT1</accession>
    <name>I4YCT1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958081.1">
        <property type="nucleotide sequence ID" value="XM_006958019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT1"/>
    <dbReference type="STRING" id="671144.I4YCT1"/>
    <dbReference type="GeneID" id="18475456"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68701"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674746_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCT1"/>
    <dbReference type="OMA" id="ARYTKGF"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="82"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="327"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42175" checksum="FF2551AAA9863E36" modified="2012-09-05" version="1">MSSFNSVESIHKYTHSFLSGFSKRDFTSNQQVKLITDFLSFIREEMEKTGQFGDLDSALLSMDKLIHRKLYHRIFKPKNDDLAKDQVLEQRVRIFSWIELKQLDLDFGLGETFNLATEQLQSINKYHCPQDKTLVILNTSIILTDILNKSPATTSADSLLPLFIYTLLQTNPSHLISNIEYIQRFTNNEQLSGEVGYYFYTLTAAVSFINNLDHKALSNIEKEDFERHVEEAISQLPSTPPASPDKPPTTPQLNIANESKQLFQKTTQGIGKIGKLLGEVVEEGVDKLTSSASANDLHSDAHRGEEGAEEAHFVRSRSEHFEQSRQQFNRSLETLIQVFPHMEPGVCELVLKAEHGNLERAVDQCLDISNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV6</accession>
    <name>I4YCV6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_68723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958102.1">
        <property type="nucleotide sequence ID" value="XM_006958040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV6"/>
    <dbReference type="FunCoup" id="I4YCV6">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCV6"/>
    <dbReference type="GeneID" id="18475459"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68723"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018649_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCV6"/>
    <dbReference type="OMA" id="DRIANEH"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="504" mass="58110" checksum="56921E2F50C0068E" modified="2012-09-05" version="1">MSLESLNLLNSERNSYGIRSDDYAKYRKHCSRRINKLRRGLKLTHGKSHKYQKVTNEAILKNKDPRVLEMLLLQSDRYWAQSSEYPPAAASKLKRSLQFSNLLLEASKKFNLHSSEFVQLVIYDKFIEASYNLSRKKYQNSLEAFSIAFIYLKNLTVAAPNDKVRALAEGWLDQISPQIRYCAYQQGDKTKAHEVERIAKESTKNYDFINVEYDQEDTTTKISGVVWRGEELKLTSVDLVDAMQKLQTVIDKKSNKTLSNFDEVLNSYSNVIDIAPEGKLKQVLTYKMLVLRIERDLEINKKLDINDAANNRSKVKILSGIIYTLEQIRNLDLVESDDLDLSAYVEVKLTNYQAFRNYTLGVAHLMANNYGPSIRLLESSKFYIRSCSDLLKNLEEEAINHPESFKPVINEEVIDNFSKDIEESIINSKKALFAQQFKRPLFFDIANTYVEPPMEYILNRSQTQDEKKAPKPANVTIAKQEEIVSQESPEPKASSGWFGSLWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX0</accession>
    <name>I4YCX0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958116.1">
        <property type="nucleotide sequence ID" value="XM_006958054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX0"/>
    <dbReference type="FunCoup" id="I4YCX0">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCX0"/>
    <dbReference type="GeneID" id="18473843"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60258"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCX0"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27715" checksum="6F9D7AA043833F4C" modified="2012-09-05" version="1">MHNTQKETVNQPSGCPVVHEKDTKINPLNNMPDLQQQPLSDNQSTRLPTERTTSSIPRPQGKSTSEGYGEGTHWEYPSPQQFYNALVRKGWETPEESVEDMVAIHNFLNEEAWKEVLKWEKRNNDGKETLQLAQFSGRPGDYTPKARLQMLLSTLFSNSFYDEPPFDRHDWYIKRTNSNETVRYVIDYYGAPPTPEGMPVFHLDVRPALDSPASILERIKVGTARCWRTATGMPVEYIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCZ9</accession>
    <name>I4YCZ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958143.1">
        <property type="nucleotide sequence ID" value="XM_006958081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCZ9"/>
    <dbReference type="FunCoup" id="I4YCZ9">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCZ9"/>
    <dbReference type="GeneID" id="18473851"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60268"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_1_1"/>
    <dbReference type="InParanoid" id="I4YCZ9"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="21041" checksum="618E16506763F5B7" modified="2012-09-05" version="1">MSLYASSKSRRKSTNTGASSILTPSNNLHQSTNINGVNLSDEQRQEIREAFDLFDTDKDGAIDYHELKVSMRALGFDLKKPEVLKLLREHDRRGEGLMEFDDFYKIMTDKILSRDPSEEIRKAFSLFDEHGTGKITLTSLRRVAKELGEPLDEEELQAMIDEFDLDQDGAINQQEFFSIMTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD27</accession>
    <name>I4YD27_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_37979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958170.1">
        <property type="nucleotide sequence ID" value="XM_006958108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD27"/>
    <dbReference type="STRING" id="671144.I4YD27"/>
    <dbReference type="GeneID" id="18472041"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37979"/>
    <dbReference type="eggNOG" id="KOG0744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028208_0_1_1"/>
    <dbReference type="InParanoid" id="I4YD27"/>
    <dbReference type="OMA" id="HCEKLMQ"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="134"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="40447" checksum="584A2A25E313056A" modified="2012-09-05" version="1">MRPIGTDTIFLSDIKMSDVWNSISSTDVALDIRTIKLAADDNTEITSNSSFVVHSYQLFDNVESDLVDLLEDEDDDDGINKEKSASVLELPNGQLEGLWDTLHFDYNIKDKLLNYINTTIKFSTRNIDQKLISWNQIILLHGPPGTGKTSLAKALAHNLSIRLNETYAQGRLVEINAHSLFSKWFSESGKLVQAMFDSINKLAEDDSVFVTLLIDEVESLTAARQASLSGNEPSDALRVVNALLTQIDKLKQRKNVLIIATSNLTNAIDDAFMDRADIKQYIGNPSTKAIEKVLNGCLNELVIKGLISNDESPVDIIAAVAKTHEASGRFLRKLPLLAYTHTQEDLPTRRGIIDSMKVCIEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD40</accession>
    <name>I4YD40_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958183.1">
        <property type="nucleotide sequence ID" value="XM_006958121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD40"/>
    <dbReference type="GeneID" id="18475473"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68791"/>
    <dbReference type="HOGENOM" id="CLU_2689701_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD40"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="74" mass="8725" checksum="81CFCEE36D44F7F1" modified="2012-09-05" version="1">MCLVFGFPSRVKETKEQNPKGKGQCPRCHNISVTYGKERYWFEFFFIRLIPLCGSNISGKARESEDRRQKTHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD62</accession>
    <name>I4YD62_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_18103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958026.1">
        <property type="nucleotide sequence ID" value="XM_006957964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD62"/>
    <dbReference type="FunCoup" id="I4YD62">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD62"/>
    <dbReference type="GeneID" id="18470753"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18103"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD62"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="37669" checksum="9DCD2E6B17D0E8B2" modified="2012-09-05" version="1">MSEAEVDLDSVIDRLLEVRGNRPGKPVQLQEYEIKYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMDQIRRVMRPTDVPDTGLLCDLLWSDPDKDISGWSENDRGVSFTFGPDVVTRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKQKFPASYGIGRPVTPPRKGKNKKESKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE65</accession>
    <name>I4YE65_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_36975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957521.1">
        <property type="nucleotide sequence ID" value="XM_006957459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE65"/>
    <dbReference type="FunCoup" id="I4YE65">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE65"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="18471989"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36975"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_1_1_1"/>
    <dbReference type="InParanoid" id="I4YE65"/>
    <dbReference type="OMA" id="TCFVQAP"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="250" mass="27040" checksum="B6DA261A913509A9" modified="2012-09-05" version="1">MATLNIDSANEIKAESENWVPLEANADVFNDWAHKLGLAECEQFVDVFGLDDDLLSMVPQPVKALLLLFPVSKNYENERHAQAADIARNGQAELDNTLVFFPQKVPNACGTMALLHAMANSPVTVAPGSDLARLFENAANQNSEERAQAVVDASFLRTAHASSAQAGQTEAPNANDDVDLHFVTFVLAPAAVSEGTRLIELDGRKVSPIDHGSSQDLLKDASAVVKEKFMKHDPGNINFALIALTTQEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE84</accession>
    <name>I4YE84_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_50835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957538.1">
        <property type="nucleotide sequence ID" value="XM_006957476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE84"/>
    <dbReference type="FunCoup" id="I4YE84">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE84"/>
    <dbReference type="GeneID" id="18472537"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50835"/>
    <dbReference type="eggNOG" id="KOG3141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_3_1_1"/>
    <dbReference type="InParanoid" id="I4YE84"/>
    <dbReference type="OMA" id="RIREPNT"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="247" mass="27320" checksum="B59485F9F9B38573" modified="2012-09-05" version="1">MWSVGSKRTGLIGVKRGMSFIYNELNQKVPVTLIEIEKNRVNQLKKPSSTNEHHFVQLQSRNQLKEFPVTENGIIPINTELNVSHFIPGQFVDIQGTSNGKGFAGVMKRWNFKGLRASHGTSISHRSQGSTGQNQDPGRVFPGKKMAGRMGGETTTVQNLKVIRIDTINNLLLVKGAIPGRDNNLVYIKDAVKKMLIDTKNKARKFGYTAQQALPYGVDDLPMPTISQEMAKSLPAVLQAPAKPQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE87</accession>
    <name>I4YE87_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_4358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957459.1">
        <property type="nucleotide sequence ID" value="XM_006957397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE87"/>
    <dbReference type="FunCoup" id="I4YE87">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE87"/>
    <dbReference type="GeneID" id="18472296"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4358"/>
    <dbReference type="eggNOG" id="KOG4135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073102_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE87"/>
    <dbReference type="OMA" id="WHVPRYH"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="21284" checksum="8808DF067BED37FD" modified="2012-09-05" version="1" fragment="single">MIINENLTIVGEKLTLVPYKEKHVERYHKWMSNADILELTASEALSLEEEYAMQKSWHKDADKLTFILVDSAIKDYRLLDGEEREEHGQPIGDVNIFLNEDDDIDIAECEIMIAEPTHRWRGFATEALTLLLGYYTQHVDNTQKRILSVKISYNNKPSLKLFTKMGFVEHKRVEVFQEVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEB7</accession>
    <name>I4YEB7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_17053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957473.1">
        <property type="nucleotide sequence ID" value="XM_006957411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEB7"/>
    <dbReference type="STRING" id="671144.I4YEB7"/>
    <dbReference type="GeneID" id="18470718"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17053"/>
    <dbReference type="eggNOG" id="ENOG502S3XY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154205_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEB7"/>
    <dbReference type="OMA" id="MDMHRLE"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="95" mass="11519" checksum="C9ECD2953D6FD0FF" modified="2012-09-05" version="1">MVYTLIVHMKAKPETVEEVKAKLHEASRIYRQDKETIDWHVMQDPKDATKFAVVERYEQESSQHYHLTNPYWKTFDPYVVPRLAEEMQLSRFEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEJ8</accession>
    <name>I4YEJ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957639.1">
        <property type="nucleotide sequence ID" value="XM_006957577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEJ8"/>
    <dbReference type="FunCoup" id="I4YEJ8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEJ8"/>
    <dbReference type="GeneID" id="18474852"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63592"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEJ8"/>
    <dbReference type="OMA" id="PEWTSCK"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="141" mass="16077" checksum="4F648CFCEADF3E22" modified="2012-09-05" version="1">MVNSFSISSLYDAPFNICARAFFLRYPNPYAGHIVSVDVLSREITPDKKLKSVRLILKRGQLPKWLPKNLVEKAESWVLEESIIDPLNKRLNSKSYNVDHIKLMRLIEEASFTAEKTNTTRHETTATVISNIGTTVSKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX8</accession>
    <name>I4YEX8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_56739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957192.1">
        <property type="nucleotide sequence ID" value="XM_006957130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX8"/>
    <dbReference type="STRING" id="671144.I4YEX8"/>
    <dbReference type="GeneID" id="18472844"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56739"/>
    <dbReference type="eggNOG" id="ENOG502SD66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1435479_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEX8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="189" mass="21153" checksum="7C41980C14E83781" modified="2012-09-05" version="1">MAAGVKARADEVISKAGGLSPAKLLRDMADNLMNIENDNKDLRKEINRILEGYYDDMDEDDHNEAVEDIRRYFKPEKNADQTEAERRHQFHSLINVGGNELKNAALETPADPYILATSHTRSIALMLLRSGIASEHPNDARKLRLTEFHKSFEESSSESDSEDENESDGNNNEERSSLTNGSANRSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF92</accession>
    <name>I4YF92_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_63268</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957300.1">
        <property type="nucleotide sequence ID" value="XM_006957238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF92"/>
    <dbReference type="STRING" id="671144.I4YF92"/>
    <dbReference type="GeneID" id="18474825"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63268"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="InParanoid" id="I4YF92"/>
    <dbReference type="OMA" id="WQRITVA"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="929" mass="105742" checksum="8CEDF8835236D91E" modified="2012-09-05" version="1">MSNRPYADPFNDRNPNEQSDIPPQRIALADDQFSPFPSSSSVNLNAGQTTPYDYPPSSFSHSNLGAYPPSNPDEDSEAKMPLTADNRLQPYYPAGFDPRTYGDPYSSPYEEPSSNALSAEADWRRRQTIKRDRAKTVKVKLTKGHFIHEFPVPTAVKNAFEPVYKNNTSTREFSHLRYTAATCDPDDFTTENGWSLRASNYGRQTELLIAITSYNEDKILYARSLHAVMLNIRDICKTRQSKYWRSAGLEGGQPGWQRIVVALITDGLEPMDKTVLDLLATIGVYQDGVMKKEIDDKQTEAHIFEYTTQLSVDTTPQLIVPHGDDPNNLVPVQIIMVAKAKNQKKINSHRWLFNAIGRMLQPETCILLDAGTKPYKKSLYYIWEAFYNNKNLGGACGEIYAQLKGGKKLINPLVAAQNFEYKISNILDKPLESAFGYVSVLPGAFSAYRYRAIQDRPLEQYFHGDHSMAERLGDKGINGMNIFTKNMFLAEDRILCFELVAKENARWTLSYVKSSKAETDVPEEGPELISQRRRWLNGSFAASVYAIANFFRLYRSSHGIIRMFFLHIQLIFNTINLVFSWFSISCLWLTFSIVITLLSKEGTSDSPIYSFGTPVVTYWFNRSFQWIWAFFVICQFVFALGNKPKAERVFYNISFFVFGILGLYLIYSAIFLTIKAFVGMKFPDGTDSIIDRLGYVLQSDNSVLVASLAATFGIYFIASFLFGDPWHMFTSFPQYLLMAPSFINVLNVYAFCNLHDVSWGTKGSDKDDALPAVKSKKEKGGEATAETNVMKQKDIDGAFQETVKRTVATKVKEKSAPEKPSQDDENRKFRSRLVLFWLLCNMIVVVIVQSADGLEPTVPTVDLEGNDDYDDIRDQFIEDSRGYEKWLTKKQSMFFKTILWTTFGITAFKFIGALYFWIKMNAFRCCRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFB2</accession>
    <name>I4YFB2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957319.1">
        <property type="nucleotide sequence ID" value="XM_006957257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFB2"/>
    <dbReference type="GeneID" id="18472862"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56824"/>
    <dbReference type="eggNOG" id="ENOG502RV3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512111_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFB2"/>
    <dbReference type="OMA" id="QEEHAYR"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="532" mass="59845" checksum="1C546CB869064D46" modified="2012-09-05" version="1">MSIRNLEIKLNDILKSNKLLSDSSADDLFSWFATHYREELSLVRLQILDLAERQSINRKFSLKSLVSLATILHRHNISRFKQIAATTNFTSFELARFVEVLVASNSNTPKILDVLHCFSINFVETLTNSSLPLLKYLNGLYNSIEKDDKLIILDILYNIIHHSLSNSNSATLISEALNVILDKTPPPELSDRPLQNASMLSDLETITESSTLLIPQTNFDLQIVGQRMELLVLDIMLISPPSSSKADMEAPPALPPRPDRDPRIDVVLDIFPDQDVSFIEKALSLPQYSNTEALIEALLEGTVHIPQDEPLEQPKYDNDEPAELDFSKLRIGKANNLKLKMDEDARNELKATVMRRVEEAQIEEIEAELEEEEEYASRPTETGDTTPTVEVDYSVLEKAYLENPSLFDRSSTTRRSKERENLRNATGLDDGQIEGWHSQLVRNPRKLQRLVQDKDIVNNNLDVPVQEGKSRHSRGGARGRGRGGASSGSTRGKAPTQGAGHSGNNRQRQNKEKQGNAQRKRGHDKKFANQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFC0</accession>
    <name>I4YFC0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1769-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957327.1">
        <property type="nucleotide sequence ID" value="XM_006957265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFC0"/>
    <dbReference type="STRING" id="671144.I4YFC0"/>
    <dbReference type="GeneID" id="18475349"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68105"/>
    <dbReference type="eggNOG" id="ENOG502RXNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047849_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFC0"/>
    <dbReference type="OMA" id="DRQGITW"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="275" mass="31242" checksum="591CEE3D8FCF66E6" modified="2012-09-05" version="1">MTIKLKILAGNSEDDYKVVDYDKGVPVDIDNAHFTGNAVVLLKDNSNPHGYFTHESNSSVTWSIQLRGLIKEDDVDCDDLIFGNQFERPIRDRLPWGTSIAVKFIKYLDPTLSEDLYSDKPWAFSPVCSTVERLNVSDNTSTNELFKEDNMILEDDVKCLTSDDDKLEHGNPTSRRRHFHNESNRKGVMLSNKIVALDFAKGFIDFSTLSLSFPEINLNIGLLKHWDGQPVRFYLRNRKTGHNLVVIQFIIEDVGQDAPEEAKEMAAHNDIGTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFK9</accession>
    <name>I4YFK9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957408.1">
        <property type="nucleotide sequence ID" value="XM_006957346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFK9"/>
    <dbReference type="STRING" id="671144.I4YFK9"/>
    <dbReference type="GeneID" id="18473627"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59918"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427115_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFK9"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="280"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="658" mass="72589" checksum="E83300DCCF635857" modified="2012-09-05" version="1">MVSLWAPGQYDFSVGCSGATSMTSLSSQDEYAEVELLEQNLLKVKNLTTSMSSILQNLDARLARLDNSVIPLQSSTNGLDVLSNNIQSALNLVDNDQRQSTIAREDETVINDGADPSDIRPYLKVVSNLSSQLEYLKHSQWSSSRDSIREITGMVEKGVRSLLRVFEGWVRDVSKPVDAEKCLSKGFADFPDIPQHAMTRLTAFVEAVSPIIKTLPPPSYTHPSIIYASERARYFNVSLQPFYKQAESSLNSYAKSGPLGASIYAKGSQRVTALINGATALADVEWQSATALFGENGDANKPFLTAVAPAITLLQSATSNVFSLAKSNPLRHIFAVLDLLDTLAPFAEKWERSITRRSTQSSKNEVTALVENARSITLRSFPDIIKYIKSHTGEEKHSTSVSNVTNDTVTYLKEILIYGDTVERNLKRLGDGGWNVSSKVMRNVPTDGETLLERYLRDVLFSLISSLTRVKSSAYSSIYVLNNLSLLRRDLIEACEPVSLDPSKTDSPSNRDIGDLLGEPAEDELNAAFRSARISYLDTVWKPALVALTSDELSTTSQGPHVPTALGGSAEKKQLIKDKFSRFNDAFAALEKLHNRHPVGKRDSQLSTRLNKEAKAMILPPYATLWGKNQSGDFAKTPSKYMKVTPDQLEGRIDKLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG50</accession>
    <name>I4YG50_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956987.1">
        <property type="nucleotide sequence ID" value="XM_006956925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG50"/>
    <dbReference type="FunCoup" id="I4YG50">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG50"/>
    <dbReference type="GeneID" id="18473504"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59699"/>
    <dbReference type="eggNOG" id="KOG2770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="InParanoid" id="I4YG50"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="306"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="395" mass="43481" checksum="1E99436385C33761" modified="2012-09-05" version="1">MKLSGILCNTIKKTPLYDWHIARGAQMVPFAGWSMPLQYKAMGQVDAHNHVRKQAGLFDVSHMQQIILKQPKSSNFIHSILPVSYNQLTNTGSYSLILTEEGGIVDDCILTKWSDESWYLVTNAARSKEVANWLTNQQGRYQDETGESISIDYLESKKQALLALQGPKAAEVLARHSETSLKELYFGNVSQNLRLSGGANVHIARSGYTGEDGFEISVEERDAVAIADMLADGNPTIPIGLGARDSLRLEAGLCLYGNDLWENDLTVGEAGLAWTIAKDRRTEDQVTKFPGWGKVIPSLKLANMSKRRVGLTVEKGPAARQNASILNTNEEKVGHVTSGAPSPTLNQNIAMGYLPKEFASIGTKVLVDIRGRKRQAEVVKMPFVANNYYREGMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE9</accession>
    <name>I4YGE9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SecY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_31680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957077.1">
        <property type="nucleotide sequence ID" value="XM_006957015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE9"/>
    <dbReference type="FunCoup" id="I4YGE9">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGE9"/>
    <dbReference type="GeneID" id="18471351"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31680"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGE9"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="478" mass="52282" checksum="6972DB53892E54BC" modified="2012-09-05" version="1">MSSFRFLQLVKPFQQILPEVSAPERKVPFNQKVAWTAVTLLIFLVCSQVPLYGIVSSDSSDPLYWMRVILASNRGTLMELGISPIVTSGMIMQLLAGANLIDVDFSLKEDRALFGAAQKLFALIISLGQATVYVLTGLYGQPSDLGAGVCLLLVVQLVAAALIVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGALLALVHLLFTWNDKTRALKEAFYRDRLPNVSNLLATLAIFAAVIYLQGFRIEIPVKSNRFRGQRGTYPVKLFYTSNMPIMLESALSSNVFIISQMLYNRFPDNLFVKLIGVWEPLEESPQLFATSGIAYYMSPPHTLHAALVDPIHTIIYVTFMLSVCAIFSKTWIEVSGSGPREVAKQLKDQQMVMAGHREGSMYKELKRVIPTAAAFGGATIGALSVIADLIGAFGSGTGILLATTIIYSYFEISSRENLSPEMASMGDLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGG0</accession>
    <name>I4YGG0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957086.1">
        <property type="nucleotide sequence ID" value="XM_006957024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGG0"/>
    <dbReference type="FunCoup" id="I4YGG0">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGG0"/>
    <dbReference type="GeneID" id="18473532"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59749"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002289_7_2_1"/>
    <dbReference type="InParanoid" id="I4YGG0"/>
    <dbReference type="OMA" id="RRAPFYW"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="216"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="572" mass="63466" checksum="0217F73629A8D64B" modified="2012-09-05" version="1">MADLESFNDNGNTPDNGSRTLPGDTSGGYSMKNWKAFTPFLGMYRDVSNRIPYYISDWTDAWNYRVIPSTLLIFFANILPALAFAFELQEKTGQYGVNEVLISTFMAAAGFSVLGAQPLTVVGVTGPITVLNTSIYTILNESTGPNPKPNYLQFVGWVYIIAAIMHFFIAIFNLSNWLRRTTNFTCQTFGFLVAFIYLTYGCQIMGRSSEADDPIESLVLSAFLAVTFLAVYHVFIFGNMSPYFFRHARRFLLDYGLPITVVAVSALPYWGRFVEIDCIKLPTVGGFSYTSSERDGWIIAFWNTPPKWVAIAIPFAALLTLLFYFDHQVSAIIGQGSEFKLKKPPGFHWDFFLLGVATLLAGVFGLVAPNGLIPQTPIHTESLVVNESRVVNETVVEEDQVKNEGHSPESTTKQRKIEVPVGVVEQRVTNLAQGGLALAFATGPFLQAVNKIPTGVLAGLFWSLGLHALYGNIITEQASYLLKDKHRTDSNDKYHKVRKSRIWLFLLFELVGFGATYAVTIIPRSAIGFPVIIILLIPFRSHVIPRLGFTQEELDILDGPAASDFTMAGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGK8</accession>
    <name>I4YGK8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957133.1">
        <property type="nucleotide sequence ID" value="XM_006957071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGK8"/>
    <dbReference type="FunCoup" id="I4YGK8">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGK8"/>
    <dbReference type="GeneID" id="18473553"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59778"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_2_0_1"/>
    <dbReference type="InParanoid" id="I4YGK8"/>
    <dbReference type="OMA" id="RTRNKFR"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="16695" checksum="CF1DB4850CFEF8A2" modified="2012-09-05" version="1">MTTEINRHHLLALYRALQRSATKFSSYNFRHYFLRRNRLAFREFLGVHPVGQPSSDSKASNPANLNAFYKEQRDQLDIVSRAAAVNRMFEGERLVVERPRIITSGGGAGMEASAGGAGQPVDPQHPRATEGGEPGETVNKAAYKDAPLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGU3</accession>
    <name>I4YGU3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956579.1">
        <property type="nucleotide sequence ID" value="XM_006956517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGU3"/>
    <dbReference type="GeneID" id="18474763"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62559"/>
    <dbReference type="HOGENOM" id="CLU_2656350_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGU3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="76" mass="8518" checksum="D89544BC827F8347" modified="2012-09-05" version="1">MDASGIFGNDYITNKETMLDFDEKSMDSKVILPTLSNGVNKDKPKLVNPTEEHGNEEVLKPHLKDLLKMMLVANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH43</accession>
    <name>I4YH43_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_15726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956518.1">
        <property type="nucleotide sequence ID" value="XM_006956456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH43"/>
    <dbReference type="FunCoup" id="I4YH43">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH43"/>
    <dbReference type="GeneID" id="18470673"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15726"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="InParanoid" id="I4YH43"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="425" mass="46430" checksum="40E39B6DFCA6504C" modified="2012-09-05" version="1">MTNLDANDKNSDIIAQGSFATRAIHVGSAANEATGAVIPPISLSTTYAQSRVGEHKGFEYSRSNNPNREAFENQVAALENGKHGFAFASGSAAAASLLHLLGEGPSHILSIDDVYGGTSRYFRQVASLSAVETSFVPLQGRVHEDEINKHWKDHTKIVWVESPTNPTMKVVDIAHLSEIAHKKGALVVVDNTFLSPYYANPLDIGADVVLHSVSKYINGFSDVIMGILITNDEHVAKKLRFFQNAIGAVPSAFDCWLAQRGAKTLHLRAERHGDNALRLAHFLASEGVKRGWVQSKDDILYPGLPWNPHYEITVEQLSKRVRNQTKDYTQGIQTGGMLSVKFSSRVNDVGEKILENLKVFTLAESLGGVESLAELPVKMTHAGVPQAIREELGIDDCLVRFSVGVEDYEDLKNDIVAAATAIYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH51</accession>
    <name>I4YH51_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956681.1">
        <property type="nucleotide sequence ID" value="XM_006956619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH51"/>
    <dbReference type="GeneID" id="18472807"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56416"/>
    <dbReference type="eggNOG" id="ENOG502S5EX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433613_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH51"/>
    <dbReference type="OMA" id="LINCTQF"/>
    <dbReference type="OrthoDB" id="3364193at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="631" mass="69560" checksum="DB282302B1163F0D" modified="2012-09-05" version="1">MKKSKALLKNLQKADKEYEQALRNASQKGDTSAAALLALGSIDATGAITSVAQLLNEINQSFEGYSSELFKSRQALAELVSQEERYSLVDRDREILVQQVIKASSKKSNGSAPEKLLSSQRELRACEVHLSEIEVDLMTNRQRIIYSSIEGRLKSLVDLGDNLIRFGEHGLENIQLLPTSANLLDNPSIDSLSPSQSASQVQEDTPNISGPITAIKNPNLKRGHSDAARAVQIVQPQDTPKPSMFTEQFSDSSIQSPGPTTTKAIRQPLIPEPLYQQQSQKKSGGFFRRLFGGGKKEKAPKQAKKHQKETEVDTHQKKSLFSIGFGSKSSHPQTDSNDNRRKSFDGWQTRTASNIKSLERDDSSDEDNVGAKYITVQNKNPQAIIADNLSRQSSVASNQSKRRRSTHRISQSALRSNSVGNGRRVSDLPERPSSAASLPILTQTAQQKHAKQAKKTERSSMQQQKITATPLLPPKVPTKNAVSNGNSQRRRPTSTSVRHRKAVVHPNLMSIVEGDGVDQDFNPAAAVVSQPKGKGKEREHLPLTSNQTRRISANNESIAPIRKGSNRSSRSEQLPKNVSWRDQPLVQRSNSVQWASRPRRNSTSSSSDEEGSYAYNAARAKLSPLDFSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC5</accession>
    <name>I4YHC5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF663-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956748.1">
        <property type="nucleotide sequence ID" value="XM_006956686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC5"/>
    <dbReference type="FunCoup" id="I4YHC5">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHC5"/>
    <dbReference type="GeneID" id="18473434"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59579"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHC5"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="815" mass="92928" checksum="3785F07B2F6CC0D3" modified="2012-09-05" version="1">MSTHSHRPSLKQTNKKFKSRGSTKRSTKTQNKGRVDTKQSSSKTSSANNLKNKQERKNQAKQLQKQKRDGLLEGKRLFEGRFGAPRIVLVLPLTEDIDGLNTVKQLLKSVGEESSALEYQGFGIYRCRISRFNQQFQFIVPTFPDNNAKFMAILDAAKIADYIIPVLSAINEVGEWGETTLRCVQAQSCSEVFGIIQGLSEVEKKEDTGIRHSLLSFIRYFFPYVQKLSSVDQLNELSNTIRSIATGTPKTPAWRDYRSYLLTEQAEWDGDLLKLTGVVRGEHLDTNRLIHIPNSGDYQIEKITNSTHPSQLNSKPNGNTMSVDEVDTGVLAQPDEEEQDDLISENEADTIGNEQTWPTEEEMAEGERLQEEAEAAEENAKSRKVPKGTSSYQAAWIVDDNDDDLSDDEESDEEAEMELEDDKPAAQEEEEEDQDEIEMDTRDNDFKDLDEDEEAKQYQEYLNKEKEDAEFPDEIDTPLDIPARERFARYRGLKSFRTSPWDPYENLPIEMSKVFEFENYDQMSKRVIKRVKMGMDEDGESTSVEPGKRVTLHIKNVSKDLSVIQSSELPLVIFSLLPHEKKKSLVNMTIQRNTEYTGLVKSKDPLTAIIGSRKLQINPIYSQNTPKGLNNVHKFERYLRHGDASVATIFGPVTWGKVPIVYLRERDDGKPPYLVGTGTFKDADPTRIIAKRIILSGHPFKVHKKTVTVRYLFFNPDDIAYFKPIELHTKYGRVGHIKESLGTHGYFKAHFDGPVTQMDTVLLYLYKRSFPKFSGLRIEGHQHINKDDPIEEAKGDEKHGEVVNTGADREQFMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF6</accession>
    <name>I4YHF6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956778.1">
        <property type="nucleotide sequence ID" value="XM_006956716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF6"/>
    <dbReference type="FunCoup" id="I4YHF6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHF6"/>
    <dbReference type="GeneID" id="18473443"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59592"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050394_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHF6"/>
    <dbReference type="OMA" id="CEDFPWI"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="24362" checksum="7A147BCC98CE486C" modified="2012-09-05" version="1" fragment="single">MTSERRLSYNDNIKLISDILEISIHTILNIRQVYPQFTFERKQKWGAIVYKSRVPAVQSYITSLVESVIEQIKQDKVENIIVIIKNKYDIPFEKFIFRIDKRIDDIEDHLKDTSFQDALAHDQVGVYARSILVRLSTLDAMLEPLKEEEDLTFSVQLELRQSSEMNNSSEWITRNNNHTKDSQDIIPVRAIDTGILNLQLLCQETEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHR8</accession>
    <name>I4YHR8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956187.1">
        <property type="nucleotide sequence ID" value="XM_006956125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHR8"/>
    <dbReference type="GeneID" id="18473243"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59242"/>
    <dbReference type="HOGENOM" id="CLU_1994384_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHR8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="13319" checksum="034948B596448A0B" modified="2012-09-05" version="1">MIQNSPINNWRYDSSPESSSTSSKQSLPSQYNTSPTSYSNSSIDNLPKLQTLSLDAPKAPVAAPLPTPPTSSSIRGTKRCRSSSQASDSSRGSFSAASSDDIGSVERKSYADGLIGEFPFPLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIB7</accession>
    <name>I4YIB7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956374.1">
        <property type="nucleotide sequence ID" value="XM_006956312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIB7"/>
    <dbReference type="STRING" id="671144.I4YIB7"/>
    <dbReference type="GeneID" id="18473303"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59352"/>
    <dbReference type="eggNOG" id="ENOG502RZXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061244_1_1_1"/>
    <dbReference type="InParanoid" id="I4YIB7"/>
    <dbReference type="OMA" id="ARQYYFP"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013220665" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25480" checksum="CD1F84B00E024A98" modified="2012-09-05" version="1">MKLLIFLALIASSLSIVIDYETLYSINSYTLIEDADSQAFIDPRLDGGSMLNRATEDLGEPLNVIISAKSDPHVLSNRGLLDFAKSVGFATECLNLHIGGPQYANLGDGQGWIKEKIELRQTYFPFFGTCWESYKGGNHFRAFRQSTTGAWFLAVSMEKKIKEHHKILEDGYNRGRDELASKALLGGYGGGYRFRTSVEWIDNLLEPGSEGVNHGIPQDGRVALLTVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIC1</accession>
    <name>I4YIC1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UV radiation resistance protein/autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956378.1">
        <property type="nucleotide sequence ID" value="XM_006956316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIC1"/>
    <dbReference type="GeneID" id="18473305"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59354"/>
    <dbReference type="HOGENOM" id="CLU_832101_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIC1"/>
    <dbReference type="OMA" id="QANREVH"/>
    <dbReference type="OrthoDB" id="10569884at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37227" checksum="2CD3ED089236FFBC" modified="2012-09-05" version="1">MKCNTCNRNNSSGMICNNCINRTLTDVRRKQQSVKNAIYLNRQSDSVKGLVDTVKRTKGHYDAARMSTRLDKLDKEIGERIHANNNIQIELRDKRNDIISRRHKLRLARDQVGVSQSQNTRRSSSLTFLELKESRRVLALECLNIYGLRGLQDGMTVIAGVLVPPLHQLQCLSHLHLLFIASTLAQILQHLSNYLSLPLPFTAHNVSSYAPTIALSETNKVFLADIAPCKTTKHVLPSLQALSMLVYNISFILSVSGYTIEHTDIVYVLNLLSRIEDSPELGAQSFAVGAPSLTSFSSLKLPLSAVTNVLSNNNMLHLSSSSTDESEDQWEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIK2</accession>
    <name>I4YIK2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956457.1">
        <property type="nucleotide sequence ID" value="XM_006956395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIK2"/>
    <dbReference type="STRING" id="671144.I4YIK2"/>
    <dbReference type="GeneID" id="18473341"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59416"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338088_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIK2"/>
    <dbReference type="OMA" id="FPLLNVW"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="333"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="704" mass="79052" checksum="E7FA397B25C7F36C" modified="2012-09-05" version="1">MAKFTKDYLSTLSTTCSTPSYPLERLHLLGFTRYSDRFKSFWSVTLKYYDKHNNSCNNLRLALLDLTPAQIATYFEEFLNALKDSNRDVKQIAHSLVQMWGNIDENTSTFITDVLISGSKVLLDERIVRALTLWISQSKVSFNIFTSILNIWTNPSFIKRVPVDQLTMYSTMILLLIQKEGVKRQIPNTLLNDSNVTHAIPSYLSLPNPFGRLLGMLVAQYLANYDGVDRLTFGDGAFSGSGPGRNEIQRLIQLVDRSRVDDGGAPIQHLEEEQSETSADDISITQHNDSDSDDSIEGYEIDYDKFNINKPDSDDEEAANDPTILSKRKVNRPVYIAELNDMLRHDGKEGNEAAVLEEVALKWAAALINDKREHRELLENSNNLAFTLLTIQDQFGLDGFEELRSEALRVLIVCSPQRAALCLIQHLFSTSISLRQRINALQAIGLGVRELSSGIPTPITKTETTTRKAIPENVANHSEVEAILKSLSQTSISDARIKAGNDMPNVARERKLKLQSSKPSKPLIVENTETPSNALEEYRLVDRQSRVQNVRFNQIASEFFIMPLINEIWFALNSQARVRLDKEFLGPLLQTLALMLWSARNAPEFIHILALESLELILALPQYTIAASVNVALAVVSLSNDIEGGRTLAESSKLPLLRRWAENAYDLLESTDENKNCAALLVKIQEIWDRHSTLVMATTLSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIS0</accession>
    <name>I4YIS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955706.1">
        <property type="nucleotide sequence ID" value="XM_006955644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIS0"/>
    <dbReference type="GeneID" id="18473104"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58980"/>
    <dbReference type="eggNOG" id="ENOG502SRE3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079147_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIS0"/>
    <dbReference type="OMA" id="FFYSEPL"/>
    <dbReference type="OrthoDB" id="2587912at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30505" checksum="CF6DA520BD8851D8" modified="2012-09-05" version="1">MINLPTELLEPILKDAFEETKGNSLLLVNPRITQVLYRYVYHQHTCTINSIKQLESFSKNVPLELLSKVKTLHLNLPSAAGSVWELVGDTLKKCRNVQHVKLRAMGLWHEDRRGLVEGLGAIDPVSFEWTSPDPPHHVSLSLVTPCLTILLHQLPKWTRLESLTLSHMQFPQCAHPDRYLPMILSPTVRFVKLGQAIRAPAKMLAGIASACPRLERLDAEDIYCESIWGSRVDEKDVRNELEDNMSFYGEFTLSSRLQRITGGDRGVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIY7</accession>
    <name>I4YIY7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955769.1">
        <property type="nucleotide sequence ID" value="XM_006955707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIY7"/>
    <dbReference type="GeneID" id="18475155"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66812"/>
    <dbReference type="HOGENOM" id="CLU_2470788_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIY7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="88" mass="9984" checksum="DE84DF1DC3A8958B" modified="2012-09-05" version="1">MPTPFKGIYSWFDRQESSQNGYLEFKHSFKDKANWLGPPDRHHEPDGLKSAARDIMSNFGKEASKASTSLCMRNYTTAIGWQTAGQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ16</accession>
    <name>I4YJ16_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_30755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955795.1">
        <property type="nucleotide sequence ID" value="XM_006955733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ16"/>
    <dbReference type="STRING" id="671144.I4YJ16"/>
    <dbReference type="GeneID" id="18471173"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30755"/>
    <dbReference type="eggNOG" id="KOG1434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3089063_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ16"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="52" mass="5624" checksum="0F35263C25280714" modified="2012-09-05" version="1">MGGASGKAAYIDTEGTFRPDRIRSIASRFNMDEEAALDNITIARAFNSEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ20</accession>
    <name>I4YJ20_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955799.1">
        <property type="nucleotide sequence ID" value="XM_006955737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ20"/>
    <dbReference type="GeneID" id="18473135"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59029"/>
    <dbReference type="eggNOG" id="ENOG502SCHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534428_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ20"/>
    <dbReference type="OMA" id="HADHEPY"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="58782" checksum="941D476E15786D1A" modified="2012-09-05" version="1">MSYFPKPFNSKDYKPPDQFTELAKSKEEKNYTEDDVNFKRYISNLKLGNTWDLIAAKYGNIDAEVDDEVDILTGEIISDRGHLRNLERITFGGRSKTDGDDDQDNSDDNSEHERELLEQHQQLMQKQRMIKDKEDLEAFLIADKDLHADHEDLYKDTRKHYYEMSNRVELSDDNDWQDDSASRSDDQSDDSVEILEKRTSYAPKSSNFKSLSKSRPRSSVEYSKARRRSSLGVPNVANISSDDAEVLSNSYNDSSDSEELSRVLAKRYEDESENENSFDKFWTEKEKKYSEYETKDYKRDRYARDKRRYTPTSSSSSSSSSSNGSPTIDRSINKSFVSDISKDVVELGESSDSSLDSYTRGRRSYLKSDSESESEKENEATKKAAVRFRLKEQNKRIMEYQQKEILNSAKKTTQFSLSQSQYSSPTTSPKRKSAPSPTRIQPAVYTPSGKLRRPPSEAMRTQSEYRPKRPTTKIGSTTDKSGLTPMMKNIMISRDRFPSPPKSSRKRLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ24</accession>
    <name>I4YJ24_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_59031</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955803.1">
        <property type="nucleotide sequence ID" value="XM_006955741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ24"/>
    <dbReference type="STRING" id="671144.I4YJ24"/>
    <dbReference type="GeneID" id="18473137"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59031"/>
    <dbReference type="eggNOG" id="KOG3889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_2_2_1"/>
    <dbReference type="InParanoid" id="I4YJ24"/>
    <dbReference type="OMA" id="EKVCIQP"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="148"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="419" mass="48136" checksum="C649407B4974422D" modified="2012-09-05" version="1">MMTHLRSLRNINTKRFSTTQIRSFANEPPKVEYDDKQVKVNWESGRTSSFHNIWLRDHCRSPHSFHSITKQRLVNTSLIPSNIKPINIESTPSGLSIKWNDGTEQPSSYPWKWLYQSSYNPKLVDDTQLRKNEKVLWDSRIANNPPTIPYEFVMNDDKGVLNWLSKIEKYGIGFVDGVTPTAEATEELTSRIAFIRETHYGKFWDFTADLKHGDTAYTDIALGAHTDTTYFTDPIGLQLFHLLQPATSGGGESLFVDGFYCAQQLKEKDINAFNTLVNTPIPAHSVGSPEAIMLPSQRSGYPIINLDNLTQDLLQIRYNNDDRSVMTNLQPEMIEEFYRSLKLWSEIITDSANEYWTPLSAGRVVLFDNWRVLHGRASFKGKRRLCGAYINHDDYASRLLTLKEKFLDENLRNTHGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC4</accession>
    <name>I4YJC4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_59076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955894.1">
        <property type="nucleotide sequence ID" value="XM_006955832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC4"/>
    <dbReference type="FunCoup" id="I4YJC4">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJC4"/>
    <dbReference type="GeneID" id="18473157"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59076"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020932_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJC4"/>
    <dbReference type="OMA" id="NFQMEPF"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="15">
        <location>
            <begin position="262"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM24066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="422" mass="47805" checksum="D290E38632D2CD28" modified="2012-09-05" version="1">MNYFRLRTGQLTKRTFYSSSRTFSAPESPFSKFVNVLREELRKNAEFQENYKQLSGEAGKVQDSEAMQRAREVYQRATIANLMKNNPRLQAATENLKKNGGKVSEGVGEALRGIENSEAFRALLRATNAASTAVSSATQPIRDTEAYKTFAETISDALDDTSRGGYEDKEARRLRRQRRLAKAGKDGIAKKRVKKDELAGEALVLHENANKPSKWQEYKDNSPLFQRMADLHEQYHESESPTVLTLRSVTDRIGGLFEENETARVTRAFKALDPDFTQDNFLVELREYIVPEVVDAYLNADKDALRRWCGEATYNVLWASMEVYLSKGLISDSKVLDIRSVEVSKGQMLDNDVPVWLVIFHTQEILLFRDAKSGKPVVGTEDGVEQVAYVGVFTRVEDELEDELTGGWKVIEMARRGQKAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJD7</accession>
    <name>I4YJD7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955906.1">
        <property type="nucleotide sequence ID" value="XM_006955844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJD7"/>
    <dbReference type="GeneID" id="18473159"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59079"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074435_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJD7"/>
    <dbReference type="OMA" id="LEIYLTW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="259" mass="29843" checksum="AFC5C501F035C38B" modified="2012-09-05" version="1">MLWENTRKQKVEASGAVEGEDDFEIDSIMDAMIGGVKGRSRQLSYKVSWRGYPEDENSWVTDEDVSSASELVKRFWYHNPDLYLDLGLTPKVVELPLSLLERENQPEEDVEEQNSNEATDDNVEDYEPAASENGSHFREPSEPSEPEMLQIQPRKRGRPSKTSSPPKKRGRGRPRKVSSPQRTNQAEESYVKSYDDTTHWDNHLKILGARESKDISEKADFKCQFDDDSIRIVGFEELVEKAPKSLCRFLSMHINFERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJF9</accession>
    <name>I4YJF9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955927.1">
        <property type="nucleotide sequence ID" value="XM_006955865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJF9"/>
    <dbReference type="GeneID" id="18473168"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59090"/>
    <dbReference type="HOGENOM" id="CLU_562840_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJF9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="61519" checksum="C6BC244DC8F75087" modified="2012-09-05" version="1">MQKVINMFTTKSKNPDHHRENDAARRAHLIMNEKPAEINESNTKDHTSKLPAELMIYMAETLIEVDSNYLVRFSQLNRRWRRTLFETSSLFEKCIVAYDLKTTFKSIRKIKWFMQFNLKHIKFVHFSDLSMYGPPEQDDPNRVLQLLEGHYDEVSMESIEITTTLGTYPRKYICYRIAEIIEHFNITSIRNLIINASFCYYDLGDLPRFSLRKFVNKDIEKLTCIGRFMGERNEEIFYIFPQVRSVIINGSVVSMGTIERMFPNLKYYELNNVILRSPPTPRPSNPYERIGVSKVTPEFLVYIAEHLSRVDNETLYNLTQVCSLWRNTLLREPQIFNRCTVTFKHKKQYKTLRKIAWFRKLGLRHLKFIYVSDLDLQTFHSYGDPQESLEILGRSDFEGISLDSVEIYLPLCPRKWIFDRIYEVLDYFNINTIRHLIINVEECYTMQSKQIELPFARFQNKCLENLTIKALLRVDSYTSTDFDLRQARSLLIENNVPIVHYLVPTTKQTEGNTADQGKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJI0</accession>
    <name>I4YJI0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl endopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_34701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955948.1">
        <property type="nucleotide sequence ID" value="XM_006955886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJI0"/>
    <dbReference type="STRING" id="671144.I4YJI0"/>
    <dbReference type="GeneID" id="18471880"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34701"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083109_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJI0"/>
    <dbReference type="OMA" id="VECEEWW"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="77"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="292" mass="32366" checksum="62D35031B5F9D7B8" modified="2012-09-05" version="1">MSQSTFNKAQQVVVYNGTSKVLPRNKSDLFSQLESLRVEYDERTKSWVLQSVLASNKPTRGIILPHGGPHAAMTPAFSAAIATFALSMNITVVMPNYRGSTGFGEDYLKELLGNVGTYDVEDCIAAMDMTEKEYAVEKDNWCVYGGSHGGFLAAHLTAQYPTRFKTAIVRNPVISLATNSTQSDIPDWCFVESGIPFDPSLQAPTATQYGKMDDVSPLKLAQNVQAATLLLAGADDQRVPNQQTRHWYHALRNHQKDVDMLVFKGTGHPLDSVEAETTGFEVTLQWFEKYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJY4</accession>
    <name>I4YJY4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_34938</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956091.1">
        <property type="nucleotide sequence ID" value="XM_006956029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJY4"/>
    <dbReference type="STRING" id="671144.I4YJY4"/>
    <dbReference type="GeneID" id="18471895"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34938"/>
    <dbReference type="eggNOG" id="KOG2879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095801_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJY4"/>
    <dbReference type="OMA" id="LTILARW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM24276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="254" mass="28643" checksum="7410372A5B9370ED" modified="2012-09-05" version="1">MRVQRLDGLELDDEVVRRITQPIIDALSLLGISTRDEIIAAIKGVYMWKYLNIFQSIYGMGLQLLKYTNLSTTKSILYLISRILIPFGHKKLKSTIETQEWRSLHRHHLKKQVVRIVDRLETLYDIANIGNHISFISGGNFANLTERALSLNVSGGGTTNVNLEFTQRQLVWSVMTEFLHSIITSRSTLQSRQTADIPLGDGVESCVVCANKNITVAYSPSCGHKYDYSCLINLIKSYTSCSVCKSKILSIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y542</accession>
    <name>I4Y542_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_3987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960868.1">
        <property type="nucleotide sequence ID" value="XM_006960806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y542"/>
    <dbReference type="FunCoup" id="I4Y542">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y542"/>
    <dbReference type="GeneID" id="18472135"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_3987"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052539_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y542"/>
    <dbReference type="OMA" id="SKMPRIN"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="5">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="19094" checksum="A027496BBD8D276F" modified="2012-09-05" version="1" fragment="single">SAYKIIETSLRLSIPPVFSNDPKSGATEMLDSLVMRYVPALGAVLLTHINTQFSQSAGLILDESPFSVTDVKFTALVWSPTNGQRMRGKVTLCSPDHISLLVHHTFNVTIPREYIDCDNFKYASDSSETGSGGRWVHKSSTQVLAEVDRELDFTVVERVTSNQMLTLTASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y598</accession>
    <name>I4Y598_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="9">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_41734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960802.1">
        <property type="nucleotide sequence ID" value="XM_006960740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y598"/>
    <dbReference type="FunCoup" id="I4Y598">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y598"/>
    <dbReference type="GeneID" id="18472227"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41734"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y598"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 9 11" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="37214" checksum="442DEFA54D2C28C2" modified="2012-09-05" version="1">MSKTVTPAELINEYNAWTVQAPMVRYSKQPFRELCASYNTHITYTPMMLSKEFARSEFARAADFSTSNSERAIFNLSRRKPNGEYEKTTEPIKGCLIAQFAANEAVTFSQSAELIAAHVDAIDLNTGCPTQWAYEEGIGSALLRKPEVVADIVKTTYDRVGSKLPITVKIRIDKEERRTEQLIKNAVMAGASIIGIHGRYRTQSSTTPVNLDGIALARSFSSVPTISNGDAWSLEQSLDIKDKTGCNGVMSARGLLANPAMFAGYEETPIECIDRFIDLSMSYGLQFPLFHRHIYYMLESKLSKTQRQSWHNVISTATALDWIEEYKESVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5K6</accession>
    <name>I4Y5K6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960745.1">
        <property type="nucleotide sequence ID" value="XM_006960683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5K6"/>
    <dbReference type="FunCoup" id="I4Y5K6">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5K6"/>
    <dbReference type="GeneID" id="18474621"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61582"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5K6"/>
    <dbReference type="OMA" id="AVMITCN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="241"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="385" mass="41862" checksum="A27AB126853FFB8D" modified="2012-09-05" version="1">MSERDNLLPQPNVGHKNAIQKTHTESFKWLITTGWKINLFLVFVPLSFISHFLNWNEKLIFVFSFLAIIPLAKLLGDATEQVALKLGDTLGGLLNASFGNAVELIVGIVALGQGQLRIVQTSMLGSILSNLLLVLGMSFFAGGISYNESEFQQTAAQASASVMTLSCITLIIPAAYESSFGSTYDGEHDGLLIISRGTAMLLLLIYAAYLYFQLKTHAYLFDSQAEEEEETPEMNTTAACFALLVITIITSFCADYLVGTIDTVAQEWHLPKSFIGLILLPLVANAAEHVTSVWMAAKGKMPLAIGVSIGSSIQIAVCLLPLLLVIGWIIGQPLTLFFNNFETVSLFVSVLLVALIIQDGKSNWLEGAMLVVLYVVLALAFYVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5L3</accession>
    <name>I4Y5L3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_22711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960650.1">
        <property type="nucleotide sequence ID" value="XM_006960588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5L3"/>
    <dbReference type="STRING" id="671144.I4Y5L3"/>
    <dbReference type="GeneID" id="18470930"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22711"/>
    <dbReference type="HOGENOM" id="CLU_075666_5_2_1"/>
    <dbReference type="InParanoid" id="I4Y5L3"/>
    <dbReference type="OMA" id="WVHIASY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="53" mass="5935" checksum="3DF0403262C20E76" modified="2012-09-05" version="1">MFRPNIWISTNKKSTVLSYEIQLSVCLILLSDLSKHAISEGFKSVTKFSSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5U6</accession>
    <name>I4Y5U6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960614.1">
        <property type="nucleotide sequence ID" value="XM_006960552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5U6"/>
    <dbReference type="FunCoup" id="I4Y5U6">
        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5U6"/>
    <dbReference type="GeneID" id="18474576"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61515"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5U6"/>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor SF3a60 binding" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SF3A3" evidence="6">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor SF3a60 /Prp9 subunit C-terminal" evidence="4">
        <location>
            <begin position="373"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="57009" checksum="FB22C66F92217EDA" modified="2012-09-05" version="1">MNSVLEDERNAHSEIDQYEDYLVELFLDVAKGQKKQMAQKHQMSKVTDRMLERREFLKNSYNSAEREQELTIIGTSQVADDLNLFYERLSSIKDYHRKNPNAPVDGFRYELDGFRDELDREVISSLFSGEETYGKYLDLHISHEQYVNLKGIPKRLNYLQYLDEFEQVEDLPKQVKAQSSYGEYLNTLVTYLESFLQRSRPFDDYSAIQLETLSKFDESWQAGTVPGWPKEEANDESKGIWDPVMQRYYANQNVYNNVKKSKKYQNALKRLESSGEKVAENGDAPASDKAAELRRSKDKTLASQEALLRLYATILAGVRKETKAEIERKSALTAREREQELEEAQYEEFTSNPIEEVVQEEKDDEGKIYNPLKLPLGWDGKPIPFWLFKLHGLGVEYECEICSGKVYNGRKNFEKHFQEGTHAYGMRALGLPNTKHFHEITKIADALALAEKLKIQGRQETQANATVEEIEDDQGNVYDMKTYNQLKKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y666</accession>
    <name>I4Y666_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mak10-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960490.1">
        <property type="nucleotide sequence ID" value="XM_006960428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y666"/>
    <dbReference type="FunCoup" id="I4Y666">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y666"/>
    <dbReference type="GeneID" id="18473056"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58718"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017051_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y666"/>
    <dbReference type="OMA" id="WILDRSF"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="409"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="88265" checksum="27A4A743CB8FE6FF" modified="2012-09-05" version="1">MAVYAQLLSASAGSDDLILDIFLIIIYSLNLSTFIQIASLYVLDLVASVLTIWYQSPSLATLMDSNEFNDITDEIYTPTENLRLGEMIYSPGFTLLDAMSAIHIGDPRMDSFLSSDKDIPESFNPQQKLSLEEITYIIDRTTALELSFYSGSHLIQSSYTSLYLHKIRSLSLDFLKLQSLSLQDGPNYEWEWLGLVLRSALVGSLKCIHYVWTELVKGVLYDIEDFNSDKANLSPGELYEDESVSFWLKEAIEWINKKIEGGQADTLITGLRDRLKLRLELLSLYNPNITNCPVVTQQGADNVSLASINTALGLIPAINACPAPSVTAKRAFYADISKYLPNMAPLPPLDESLLQIEGTNVWEGFRPSLESMKDINKAICNQDPLEWINWTSFKSIITPENKTLPAYVRNLVLSRFITDENLIFDQHSIEWITDKLLEDTIGLPFGMVGLIGQFNRTTLTVVRHSEMSIGLAFQLWSQRLAGFYVNLLTTYCHNRSRQKRNIPKSIKQFQELYEEALTFIEQSAESVETLSPTLSSLVRQIPFVIRSFILSLNIEALLVSTELELLDSEHDWTIIYWQLRRVAYIWQQELYDARSKLNALPVDERVGFTDNLKRNAEEWMKERTKYANLIELLSKATLNSFFIHKLPESLMTQPERQARFERRLKWCMRGNIDSDGSLETDPKYTQYEIDLNDLQKSAVPEETLSYYKSSVERIDELLELDVHKVKCSLSKDKRYNLLQSLRQICEVNISNFSNTSAAWSNDIHPWYPNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y689</accession>
    <name>I4Y689_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">WALSEDRAFT_52797</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960513.1">
        <property type="nucleotide sequence ID" value="XM_006960451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y689"/>
    <dbReference type="FunCoup" id="I4Y689">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y689"/>
    <dbReference type="GeneID" id="18472595"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52797"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y689"/>
    <dbReference type="OMA" id="KRTWLIA"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="105"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EIM19481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="201" mass="21783" checksum="26BDF589510D9AB6" modified="2012-09-05" version="1">MSMLPPAPSRKFSTSSKALDTTQVPDFSPYRSKNTGSNKAFSYFMVGSMGLLSSAGAKATVTDILSNLSASADVLALAKAEVDISAIPEGKNVTIKWRGKPVFIRHRTASEIEEADKVEMSDLRDPQKDADRFEQREWLVMLGVCTHLGCVPIGEAGDFGGWYCPCHGSHYDISGRARKGPAPTNLEVPVYSLNEDKLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y691</accession>
    <name>I4Y691_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein MutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_55585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960515.1">
        <property type="nucleotide sequence ID" value="XM_006960453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y691"/>
    <dbReference type="FunCoup" id="I4Y691">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y691"/>
    <dbReference type="GeneID" id="18472736"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55585"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y691"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="214"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="678" mass="76009" checksum="3F4BF2129C748091" modified="2012-09-05" version="1">MNNGRIRKLDELVVNTIAAGEIIHRPANAIKEMLENSLDAGATNIKITIKDGGLKLLQIQDNGGGISKEDLPILCERFTTSKIRKFEDLQTVSTFGFRGEALASISHVAHLSILTKKVEDNAGWKANYSDGKQIGEAKPTAGNKGTIISVEDLFFNVPMRRRALKSANEEYNKIVDVVTKYAVHNPTVSFVCKKVNANVPEISTLSRSTTVMNIKALFGQQVSKELLRFESEDQELDYKCSGYATSTNYASKRTTMLLFINHRLVDCPPLKKSLENAYSALLPKGSHPFVYVDLEIPPQNIDVNVHPTKSQVHFINEDEIIEHLVDALSIKLSSSNTSKSYDVQTYLPKPMPIAQISNPKFIATFAKPAPKAQVRTDGTTRTLDSFIPITQKSSSPPPPKASASTSRITSTPLKRPAEETPQHTPASTQSMRTPIEKVKSNKNNLTSVRNLRQAVIDNKNEDVARMIKNHTFVGFVDMSKHLALIQHNTQLIMLDYKFFAYELFYQIALNQFGNMAKFELNPPPNIRILIEIALKAEEENILESGGEVSLILEIVNLLTSKARMLDEYFSITINESGELERLPLLLKDYTPDINAIPTLLMNLGPLVNWEDEQECFDQILKQLALFYTPSKENSEAVRWQIQHVLFQSMVKNLTPSDSLNAITEVTSLQNLYRIFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6P4</accession>
    <name>I4Y6P4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960299.1">
        <property type="nucleotide sequence ID" value="XM_006960237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6P4"/>
    <dbReference type="GeneID" id="18473039"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58622"/>
    <dbReference type="HOGENOM" id="CLU_2005679_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6P4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="124" mass="14106" checksum="E5C9953713CF3053" modified="2012-09-05" version="1">MSTSLNIYLKNILQNTLDKSNKVSLDKLRLARNNCLEKHLVMNANKNIEQEEEEDEIIIDNQLFSDTLGSPPPAPPQHHPPPKNALKRPLHDSLNYPNKRSRKPKAVIVSSDEDDDVDPEFSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R0</accession>
    <name>I4Y6R0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960315.1">
        <property type="nucleotide sequence ID" value="XM_006960253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R0"/>
    <dbReference type="GeneID" id="18474492"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61375"/>
    <dbReference type="eggNOG" id="ENOG502SBHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1504605_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6R0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="20153" checksum="58F4267995ED22D9" modified="2012-09-05" version="1">MLTAKDASGTKEKEKEKEKEKEKEKEQPSTSSRSPSVLSTHSSSTTLKKSASTQSAKESTTKRLRKEDSTTKARQRTKVDYTSSEESTPPPPKPKLKGLDKKLNDDENYRELYQQYSSAMNTLQIQHALYKGEHQGTHQYPTMLLGEGAIQALVIGVNQMHNQLNEIRNKHSQSHPNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T0</accession>
    <name>I4Y6T0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960333.1">
        <property type="nucleotide sequence ID" value="XM_006960271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T0"/>
    <dbReference type="STRING" id="671144.I4Y6T0"/>
    <dbReference type="GeneID" id="18475746"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70469"/>
    <dbReference type="HOGENOM" id="CLU_1760241_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T0"/>
    <dbReference type="OMA" id="DIWPKEF"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16780" checksum="B857105557E39DFE" modified="2012-09-05" version="1">MEEDQKQIIGRVGQPMGSNQFTVDVPDNLINKSSDDSTYTQVLVQLGRSMTSSKKTKTWVKRGSLCYLEPYNDDKIKVWGEMVSILSANDEKALKKSNNWPKAFTQTPPQSQNTQENVENDGDDDLFVNPNRRTVVEESDDSEEEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U1</accession>
    <name>I4Y6U1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960191.1">
        <property type="nucleotide sequence ID" value="XM_006960129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U1"/>
    <dbReference type="STRING" id="671144.I4Y6U1"/>
    <dbReference type="GeneID" id="18474457"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61315"/>
    <dbReference type="eggNOG" id="ENOG502QRVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6U1"/>
    <dbReference type="OMA" id="TVWEVKD"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="34751" checksum="AD06D99D07C6BB26" modified="2012-09-05" version="1">MLSSINDVCKNAALISCPMLGSDEGIEPVCYARNIVIGGTLIFQPATCFIHIVAIFMTVIMLYHIRTKYTAIGRKEITLFFYLYGICELLAIFLDSSVIPTSHETYPWFAAIYMGLTTAMFWCLLVNGFIGFQVIEDGTTLSVWTMRGSSFVLGALSFFVHIATYKNIPGFDRSNPIAVTIFTFILHIICVGIYIITQFILVLRTLDDRWPLTNIAFGVGFFVIGTVVLLGFSVQVCNSVDHYIDGLFFETLCYLLSVMMVYKYYDAITKEDLEFSVGSKGNVWEVKDTAILQDTSHNDTKYPPTTHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6W1</accession>
    <name>I4Y6W1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_48608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960211.1">
        <property type="nucleotide sequence ID" value="XM_006960149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6W1"/>
    <dbReference type="FunCoup" id="I4Y6W1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6W1"/>
    <dbReference type="ESTHER" id="walsc-i4y6w1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="18472458"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48608"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_0_1"/>
    <dbReference type="InParanoid" id="I4Y6W1"/>
    <dbReference type="OMA" id="GAWHGNE"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005136186" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="556" mass="59956" checksum="8FEAA772879DD218" modified="2012-09-05" version="1">MFKKLICALATSAVVVAAPGTQTKRDTPSVTLPQGVAQGTTTTLPSATSPVHKYLGIPFAQSPPPRFEPALPLEGESSEMIDATQWKHKCIQTSNGSTRNVDQEPDDDEDCLYVNVYAPENALEVGNKTVLVWIYGGALQTGNAGRSDYDGSSFAANQDIILVSFNYRLNVFGFSNAPSLDATQTNVGFHDQRLALDWIKNNIAAFGGDPAKITIMGESSGAASVDRLLLNPPEGTPFRAAIMQSGQASLSPLADDDGVSKWQNLVTEVGCATSNITDEQYACMKEVDATVIRDAVEKLSLSFFPVNDNVTQTATPLKDAIKDGKGAQVPLLMGTNTHEGSVFIQPYLENAIGDDGKLNTTQLTAVIEDFGVLPSGFTTLIKTFLDSLLLVSADHLLNSLSNLVTSLVFKCPASEIAHAHLDTGKTVYRYSFAPTYNDTQLDKVIPEIGIKNIGAYHAAEIPIVFGTYDTYQSVAPATDHEIQMSKFMQTAWANFAKDPTSENAPGWNPVNHWRINDIACLGCVENSTGLTTKSELEFDGDCLVLNNFYTASKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X2</accession>
    <name>I4Y6X2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960222.1">
        <property type="nucleotide sequence ID" value="XM_006960160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X2"/>
    <dbReference type="GeneID" id="18474465"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61330"/>
    <dbReference type="HOGENOM" id="CLU_1157171_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6X2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="28161" checksum="FDA1E7DD9C2908EA" modified="2012-09-05" version="1">MTIKQVLKGKNLSNIKNSFYNSIIDGRSISPYNQRLIVSRFVNNDFDFVLSFLSILKGYTHLDSRLLNHTISTIPPNDLHDRLDDLKLFNLDIENYNLILKRFSKFSRRHCVELFDNLAASDNVNNKSYKYVVKSILNQPQNTSLDYVIINRLYRHIDSFDESLTRQLLELFIMAEDTQNSLELYYNHKLLLDNVSVFKLVNFFIKFDKSAALDILNDWLRFNELTPSLHLLELKLTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X3</accession>
    <name>I4Y6X3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960223.1">
        <property type="nucleotide sequence ID" value="XM_006960161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X3"/>
    <dbReference type="STRING" id="671144.I4Y6X3"/>
    <dbReference type="GeneID" id="18471760"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33852"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y6X3"/>
    <dbReference type="OMA" id="YPNFEGY"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="198"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="456" mass="49782" checksum="86FED3A547AA902E" modified="2012-09-05" version="1">MWKDKFIIEDAGLTKIKQEIQREFRDGLNNHGTDVSMIPTYVYGIPDGTEQGTYLSLDLGGTNMRVCEIILSGDKQFTITQEKYKISEDLKTGEFAHLFDYMAKSIGHFLSTKSESKDSKRIPLGFTFSFPVDQSAINSGKLIGFTKGFKAKNAVGKDVVKQLQDSLNQQNIPVDVVALVNDTVGTLLAHSYKSGGAKIGAIFGTGTNGAYLEDLSEIKKLDLSSLNVKEGSKMVVNTEWGNVDNGRSVLPINEWDEIVDSASINPRKQSFEKLISGMYLGEILRRFLVHLHSTKEFLSQVETLPEGISTQYGLDTALMSAALEDADEAEYENAKKVLVDLGVSEERVSIEDARILKSASYYIGLRAARLSACALAAVIESETRENTTGDINIGLDGSVIEFYPSFEQQIRDALKVLLGHGAEQRIKIGLAKDGSGVGAALCALQAIKQLNGKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y728</accession>
    <name>I4Y728_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960105.1">
        <property type="nucleotide sequence ID" value="XM_006960043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y728"/>
    <dbReference type="FunCoup" id="I4Y728">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y728"/>
    <dbReference type="GeneID" id="18471744"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33779"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_1"/>
    <dbReference type="InParanoid" id="I4Y728"/>
    <dbReference type="OMA" id="GAIETMK"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="445" mass="48383" checksum="CE771E4DBB30DA1B" modified="2012-09-05" version="1">MVDLIEKGKLHVAAGCGRIKEHIIERGEGSWVYTNEEKLLDFTCGIGVTNLGHCHPRITKAAQEQVGTLVHGQCSIGFTRPYVELIEKLLQVMPDPSLDSFFFLNSGSEAVENAIKVARKSSGKTHGNIICMQGSYHGRTYGASALTKSKTIYAEQVGNGMPGIYTTPFPYAHQMGLPQSTSEEELVKHCLFQLEMLLAQQSAPVDTAAIILEPVLGEGGYVPAPTSFLHGLRKICDDNNIMLILDEVQSGFGRTGKYFAVEHSGVRPDILVIAKGIANGFPLSAIVTRKELTDKMPKGSLGGTYSGNAISCAAGVECANVMKEEQILDNVNARSVELFTALKQLQDDHETKDFIADVRGLGLMIGVEFVSSTKHPIPSAVIKNSTPDNIGAKVQKKCLEKGLMLLTTSAFDVIRFIPPLTISKEEMELGCKIFKESVREVVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y756</accession>
    <name>I4Y756_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_70322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960132.1">
        <property type="nucleotide sequence ID" value="XM_006960070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y756"/>
    <dbReference type="STRING" id="671144.I4Y756"/>
    <dbReference type="GeneID" id="18475714"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70322"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040459_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y756"/>
    <dbReference type="OMA" id="DWHTYTI"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697448" evidence="6">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="7">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="88"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="362" mass="39959" checksum="6DB7972BA9D1A86E" modified="2012-09-05" version="1">MPNARRVLSVTLLAALIATSQAVLNGGSCSAATGLTCPEKNPCCSEFGHCGDTVAHCRGGCDPRVSAPNACSNVPICEDLEIKAFDRTAWSRVTQKPEDYNGEADQYDFTLDKGDITREENMLTMIMDEDNKGTRLSSTRYMLYGEFNARMRVTGTNGVISTMILMSDIHDEVDWEFVGAKTGEGQSNYYYQGVTDYTNGDTHKFPTDGQFHDFGFNWQEDKLEWKIDGQVVRTLRKDDTVGWDKKAHYPESPSRLQFSVWPSGIEDVSPGSFEWGGGKIDWSKGPFKATIQSISIKCGQSSEVPIGPDDISWEYNNQTSSQIAFQASPEPYKASSGGSSLHVSSPFTLMLSLSFALLYLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7E4</accession>
    <name>I4Y7E4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960028.1">
        <property type="nucleotide sequence ID" value="XM_006959966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7E4"/>
    <dbReference type="FunCoup" id="I4Y7E4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7E4"/>
    <dbReference type="GeneID" id="18474411"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61238"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7E4"/>
    <dbReference type="OMA" id="AYMITLN"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="151"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="759" mass="86757" checksum="CCCC024F87308A41" modified="2012-09-05" version="1">MTGRATQRNTQRQSFTALYSMAAEQDVDADDDLARAQKRLRELKSKISSQSKKNFVLERDVRYLDGRIALLIQNRMAADEKEEVAQTLEETDDSAGWLDDRKVQQYANLFFLLQSEPRHIAVLCRLVSLAEIDTLLQTVMFTLYGNQYESREEHLLLTMFQSVLSAQFETATEFGSLLRANTPVSRMMTTYTRRGPGQSYLKSVLADRINSLIEHKDLNLETNPLKVYEQMLNSIEEEKGVLPPGLHRGVSTEVAAENPDVQAIIKPRITMLIEIANSFLYTIIDSIDAVPYGIRWICKQIRSLTRRKYPQATDYAICSLIGGFFFLRFINPAIVTPQAYMLVDGIPAKHPRRTLTLIAKMLQNLANKPSYAKEAYMMQLNPFVENNKARINQFLNNLCEVGDFYDQLEMDQYMALSKKELQINITLNELYNTHALLIQHMDILAPQSKQHLRILLDELGPSPTLVPRKDNRTINLPMFSRWETPIQDLTTALMAESNITQNDILYMEAKSIFVQLIRSMPGADKIPVDLPAIAERAATTKDPILVKKGIKVKEMLRELEEIGIIDRSDEYNLMQEEVQAELAHLGNIREKVLVESKSLDSVYKTICDHNNYLRSQLESYKAYLANVRINSSKDSKSSAGGVGVVTVGGKEKKPAKSHILGPYRFTHYQLEKEDIIRQSNVPENRRNNIYFNFTSPTPGTFIIALHYKGREKAILEMDLKIDDLLEKQKDGVNLLDLEYVQLDVDRVLSLLQKSFSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7E8</accession>
    <name>I4Y7E8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_65888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960032.1">
        <property type="nucleotide sequence ID" value="XM_006959970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7E8"/>
    <dbReference type="FunCoup" id="I4Y7E8">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7E8"/>
    <dbReference type="GeneID" id="18475062"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65888"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038617_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7E8"/>
    <dbReference type="OMA" id="FINEHAG"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012067873" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="124"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="40206" checksum="B6BD757C25DD988E" modified="2012-09-05" version="1">MFKFILAILIGIASAIVLDLNKDSFYSVVNGDADVLVEFYAPWCGHCKNFESTYNSIDEAFDYTNKLKIAKIDGDENKKFIKQFNVQGFPTIKLFKKDGEIVDYKDRRDFDNIINFINQQVGIKPMVEESNVIELDGGNYQSLTDGKTTLIEFYVPWCKHCKAVEPIYTELSKIFKYEDNCQIAKLNVDNKDNKEIVDQFNVSGYPTFNLVKNEEKHIYNKARTLDHFLKFLNEHCKTDRDLNGELGDKAGVNHEYNAIIVRFLRSNNQQRLEIIETLNEISDKVYLRVMSKIISDGVDYLSAESNRLNNLLATNLRQEQKDKFKIKSNILTHFGTLLAADHHQHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7E9</accession>
    <name>I4Y7E9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960033.1">
        <property type="nucleotide sequence ID" value="XM_006959971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7E9"/>
    <dbReference type="STRING" id="671144.I4Y7E9"/>
    <dbReference type="GeneID" id="18475063"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65889"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y7E9"/>
    <dbReference type="OMA" id="CLYGHQL"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="37853" checksum="0C24DB2185537B95" modified="2012-09-05" version="1">MFKPFDHLLQELEFDEEFDTLISLGDIVNKGPESTPVIQKLSDINALAVRGNHDQKVIEWKAWFDQVESVKGGKEWLELGAPKNLKPKRALSLPKSWEWQGPHFQIAKELNDTTKEYLFNTPVLLHIPQHDLYAVHAGMLSHDPTKPKSAINPNHVNGDIDLWSIPQNTPDNMIEMRSIDPMGKPIKKPKGGVKWYEYWNKDMETCHGDKCIPHRIIYGHAAARGLDLNEYTYGLDTGCCQGRRLTAMVIHPESTIEAAHHHHHKKGRKGKGKKGDKKHKGDGNKGGDDDKKHKGDGNDEGNDKDGGKKKNSSKLKFERDVPISSATTGQIFSVGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7H6</accession>
    <name>I4Y7H6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960059.1">
        <property type="nucleotide sequence ID" value="XM_006959997.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7H6"/>
    <dbReference type="GeneID" id="18474421"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61255"/>
    <dbReference type="eggNOG" id="KOG3630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243994_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7H6"/>
    <dbReference type="OMA" id="AFGNMFS"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1450"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1526"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1423"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="987"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1124"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1450"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1608" mass="172656" checksum="AD5A0D738CE2F9B0" modified="2012-09-05" version="1">MDAAPPFGVMSRLPYRYYVWLRDWAPFRNILFVASGPSSDIGCVVTPDASSANKNEVFGEGETVATAAMLPETSRPALPMSDEQEETFPVGLDLDLGEKDPLKPEPGSAADTPDGPPAPAIWTLNSEGKLFAWWLINSYGAYEHMRAPNDTQEQSMAEDKQTAAFTTMAEAEAAAKPPVAPSGGFVGNEPKKPTEFANVSANAFSAKPSSTSFPSSSGFGQSSGFGQSSAFGQSSAFGPTSAFGQSSQTGGGFGAFANKPNALGSPQTQNKDEKKDEKPSAFGKPTAFGQASGFGQPSAFGQTSAFGAPKKDNEGTSTTSPSTTGGFGAFAAKPASAFGTTSAFGTPKKENETTSASTPTSGGFGAFASKPSVFGSGQKQEDKKESVNAFGAFSGTGTSAFGQSAFGQSAFGQSSAFGQSPFGSTTPKADEKKESTTPTASAFASKPTAGAFSFGQNSPTKLGSGTTGAGFGFGGVSSGSNSFGLRNPPQDAPKKDEKKDAEVSDLLSGFGSGAKIDVGCMKDNSEKQDDAESDGDNVDDTFAYVKEKERDEEEREKQQKERELEDVRKQEEQKKLAEEEAKRKQKEEEVKKKEEEAKKKEEEEIKKKEELAAVAAQEEEKQKKQEEAEQKKHEDTTKPEEKQETPNIFASALAKGNNGQQTCSTCSLQSPSDATKCTVCETPFKKPEEAPKQNAPPSQGKSDTPNVFAKVLAKSKEGKQQCPGCTLDQPVDATKCGVCDYALKKDTEKPEAPTMPTAPPAAPSGSGFTFGGGSFGSSIQKPSGGFTFGASSGADKKDDTVKAPSTGGFNFGGASFGTPTADKKEEKKDDTVKAPSGFNFGGSSFGAKPATEEPKKDDTVKAPSGFSFGGANADAKDDKKKEPKNAFSFAKPTENKAQNAFAFGGFRKPENDSPNTKNAFGFGSGTLPPGNQTSTFGSPSGFSFGNQPVPSQELETKKDDDRTKSFFGFASESPSRRVSQEHQPAADVEEDSGEEEHDDSQETGEEDEEETGESEDFEQVDDTIEEEDEEDDDEEEEEEEEEEDAEEDQAEDEQENDESTTPPASPEKTQPSSSLNFTSSAFNKPGQQSPFAFKPRESSPLALSSIDNAASPDKIKNTFGGFGQQPSSNITTASGSPSMTMAQNALKPNLFDAPQNPTFAGFNPATSPQQPSGGMMFNSKAFNEAFSKQSPTSSPGPLATPVKKVHNDNESYSIQTPNKPPKLSLLNVEVPKNKLEGTSGMSAEFLKMYLMVEQEIDMLKQNVKSCVDYHEKISKKRQSVDDYDIMALYDKTQWSLGDLDLIKKLSVELEANTIDLKDSSLAQKRKAVELQSLLLKAETKKEEISRFIRARNDPEFARIVKVRQLGPEHSENQQKLRKSMQALNDGIMSVEDQLNTIKTKLMQQKTGGKSFKVPSIDSINRTIRTLSIAINEKKSNLDELIKRTEKLTINNSNKGGRKSSTSLNRSESISATLPEPDRNVIDKALSLEARRAKLAATLKARQPKASLDDTEKYQFRRNEPLSLIDVPSAEAIRKKRAEKEKTKSTSTSTQPTNEKVDVSDIFSPGSRDTESHSRHSRHKSEGSSGRQRAVQLPKHNSPVIASDFFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Q6</accession>
    <name>I4Y7Q6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959929.1">
        <property type="nucleotide sequence ID" value="XM_006959867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Q6"/>
    <dbReference type="STRING" id="671144.I4Y7Q6"/>
    <dbReference type="GeneID" id="18475053"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65790"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020826_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Q6"/>
    <dbReference type="OMA" id="ISAHINM"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35329" checksum="F9EAD77D4062E154" modified="2012-09-05" version="1">MSDKIAIVFVHGFKGGADTFGDLPSDLESALNEESKYSTLIYPPWKTSGKLEVAVDDLQIWMKEKYQEFGYTSYVLVAHSMGGLLAADLYLKDTYEGGHLNIKAVLNLDSPMVGLHPNVFAHTTAKFGDYYDKFNKIKEIAGGATVLAPFVGALWGTTRLNESERIAKEEEEKKTKQQQQASTSYIKPAGAAIATVSALGAGVYFGRDKLLEAYRWTTGQTVDHLLFLSNLWNSRMLKERLESISTNDVLFKNYYTHLPHLNDRTFCLIPSNNKMFIKASNTLASDEVGAHIGMFNASSNSDYHELIKNLVQDIRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V1</accession>
    <name>I4Y7V1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta(14)-sterol reductase ERG24</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_52442</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959972.1">
        <property type="nucleotide sequence ID" value="XM_006959910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V1"/>
    <dbReference type="FunCoup" id="I4Y7V1">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V1"/>
    <dbReference type="GeneID" id="18472583"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52442"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y7V1"/>
    <dbReference type="OMA" id="PNYMGDL"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM20043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="438" mass="49923" checksum="CF91E8986983A039" modified="2012-09-05" version="1">MTISMSKAARNPDYASLNPQTKEYSFYGPLGTSAITIIAPIATYLLYFACPNSTDEGTCRLIQKPQLDNVVSLSFLQSLFKVEAFVVYLAWYAFTVIAWAIIPSIWVKGTPLRDGNHKMYKMNAFNTLLLATGLAIIQIIKSGPHGFTYLADNWIPLLTSSLIMSTAQAIYLYAISFKGDRLLALGGNTGNLIHDFFLGRELNPSIGSFDIKTFNELRPGLILWWLIDMSLVCKQYTNYGRISDSMLLVIGFQGWYVFDALYCESSILTQMDIVVDGFGFMLAFGDLTWVPFTYSLQARFLANHPNDLGMVGVFCIVALLLLGYYIFRVSNAEKNEFRTGNNPKNLQFLQTKRGTKLLISGWWGFLRHPNYLGDWIMALAWTLPAGFLTPLVYFYPVYFLILLIHRSIRDDAHCREKYGDDWERYLEKVPYCIFPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W6</accession>
    <name>I4Y7W6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">catalase</fullName>
            <ecNumber evidence="3">1.11.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_65849</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959987.1">
        <property type="nucleotide sequence ID" value="XM_006959925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W6"/>
    <dbReference type="STRING" id="671144.I4Y7W6"/>
    <dbReference type="GeneID" id="18475057"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65849"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264538_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7W6"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 19" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Catalase core" evidence="21">
        <location>
            <begin position="569"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="487"/>
            <end position="524"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="SMART" id="SM01060"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EIM20058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140758" checksum="3810447BEEEBB87D" modified="2012-09-05" version="1">MDKPVPDNYRLTKENSANILVPISETSDNKAFINPIQEFNRDLSVAAIRVWSEIVRAEKSAKFKSKRKGKKNAEEDANWKFKFSILDALSATGLRAIRYAKEIPNADKIYANDFLPDAVEAIRRNAEYNNVADKVKPVEGDASALMYQHRSGSKFDVVDLDPYGTAAPFVDAAVQCLSSGGLLCVTCTDTAVMAGTNYPEKCYANYGGTPIRAEYSHEGALRLILNSLSQSAARYGRYIEPLMSLSIDFYVRMWVRVHDGSGEVKKAFSKTGSVHVCSFCRQHAIQPFGRITVKTNEKGNTSSRFQAAQAINQSDKCSECGAQYHTNGPMWIDRIHNKDFTKRMLEHIDQNADKYGTAVRMKGMVSVADGELEDSPFYFTTDSVASAMRMTAPPMVTIASGLVNAGYQVSRSHALAGSIKTNAPSRVIHDMFRKWMKTHPIKLENIKEGSPTRVLAMKEAEVDADLTHNQAVVDLLGSKEKLRRYQSNPANWGPLAKPNSGPQNTKNSSEEHANDNATSDDVDIHKSKKAKIDMSVYDSNKPVQQNTKLEQLATATRDVPAEGEGSIHRTTFGAKADNVELTMKAGRRGPTLLSDPVFRDKISHFDHERIPERVVHARGDAAHGFFKLHTSLEDVTHAKILTDTVTETPTFVRFSSVLGSAGAAETAREVRGFATRFYTSEGNWDIVGNNIPVFFIQDPTKFVDLIHAAKPDPKGGLPQAQTAHDNFWDYMSLLQESPHMVSWILSDQTIPRSYRMVQGFSVNTFVLVNKEGKRTFVKFQWKPHLGKHSLCWDEALKLGGQDPDYLKRDLQMFIDSGIYPKYELGVQLVPEEDEDKFSFDLLDCTKIIPEEEVPIKWVGTMTLNKTVTDQFAENEQVAFCTQNIVPGIDYSDDPMLHGRNFSYFDTQISRLGGINFSQLPINQPLPQACPFMNTLRDGYSSKVIPNGPNYYPNRFNNYPKPASVEEGGLHFPPYQVGGKRERNLGEKFFEFYDQATLHFNSLSDIEKANFVSTSHFEMGRCDDVGVRTRMVERLNHIDHDMAVQVSEGLGIKCPPAVKKNHGRKSDGANPISMLSKNNVFKPEGRLIALVAPDGYDHQQALAIQNAFLALGNIVAVVGLRKGPTYGKQEGQELPTNFTFESARSTLFDSVIFLDGDDRYKKTLNLGRVKHWCIEAYAHFKAIALIGTSAEWGSKLIPVENRTDGGKSFSVQDGVVVAPKLTSQDTSLFDKLTKGVIDAASFAGAYAQAVASHRHWQRDPSELAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Y1</accession>
    <name>I4Y7Y1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959794.1">
        <property type="nucleotide sequence ID" value="XM_006959732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Y1"/>
    <dbReference type="FunCoup" id="I4Y7Y1">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Y1"/>
    <dbReference type="GeneID" id="18471702"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33536"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7Y1"/>
    <dbReference type="OMA" id="TDWWGRA"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005136189" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="55"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="662" mass="72538" checksum="1F9EBE49ED7D7FFA" modified="2012-09-05" version="1">MKCTAITALAIASIAHAFPSSPEELAARGVLQGAKFHALHSRDEGELSYEPYNTTCEIRNGFIRTGQELSSNETDYINARMDKIIDPLRNWLDGANLSYDIEQLTNNATNAPKLGLAISGGGYRSMLGGAGFISALDNRNTSLDFETAGLLQSAAYMTGLSGGSWAVSGFAAQDMTPFWQLNDDVWKLDENIFWPGILDAYTYFKEIFEDVAAKKHVYPEDSFQTQITDFWGRALSYHLLAEPEEKFPGYGRNTTFSSAITGASTFQSHEMPYPIVLAVERQPNQLIIGQNASIWEMSPYEWGTFGPLGGGNAQDSPNGFIPIEWAGTSIVNDEVNTTDCVKGLDNFGFVIGSSATLFSAGVQQANASITGFDVFQRALRDILGDFSESMDDVALWKNPFYGWENDTNKIAQETNVVLVDGGLNDENLRLDPHLKKERQVDLVLAYDGSADTTYSWPNGTSLYATYNRTIHNDSGRSMANVPTPDQIVAQGLNTRPTFFGCNATDVTNYDEANKAPIIAYIPAYPYVYPANTSTFKLAYEAEESAGMIANGEAAMSLNGLVNDGEWKRCLACALVDRSRERNNIDRSPECQSCFNDWCWNGDQVDTADVPEYEPEINSVPQFVQDRSDGSALIQPYESGAVSGLYSATALLAVTSLVGAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y848</accession>
    <name>I4Y848_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_58363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959861.1">
        <property type="nucleotide sequence ID" value="XM_006959799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y848"/>
    <dbReference type="FunCoup" id="I4Y848">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y848"/>
    <dbReference type="GeneID" id="18473009"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58363"/>
    <dbReference type="eggNOG" id="KOG1106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y848"/>
    <dbReference type="OMA" id="AAYKEIY"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="19601" checksum="C15C856ECCE1568B" modified="2012-09-05" version="1">MDFDSYYSIDSIIADNQKVPSEFLTDVPSLGWLQGGLDKDIKEGSKVDLPYWMSSTLALSEYDFLNLSIPGAFSGRVSNALLASPTYVKLANLNHFWYSFGLRISDLLEDNAKLQQSLRLAFSQRLIEIFDLGQYEGNVEDKSFESEFKAGMDELEKQLLEHCSRSAAKHKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y872</accession>
    <name>I4Y872_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mov34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959884.1">
        <property type="nucleotide sequence ID" value="XM_006959822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y872"/>
    <dbReference type="FunCoup" id="I4Y872">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y872"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="GeneID" id="18474364"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61160"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y872"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="33847" checksum="387DD2EB49F0BB9A" modified="2012-09-05" version="1">MDINALLAQARGGAQSNPTGDTQIADNGETIHISSLALLKMLKHGRAGVPMEVMGLCLGEFVDDYTIHVTDVFAMPQSGTTVSVESVDHVFQTKMLSMLKQTGRSEMVVGWYHSHPGFGCWLSSVDINTQQSFEQLNPRAVAIVVDPIQSVKGKVVADAFRLIDSQNALMGQESRQSTSNLGQLIKPSIQGLIHGVGRHYYSLAIQYRKSKAEERMLSSLSGKAWTKGLEIEQADKFRHNNQNAVEKFSTLADQYGKSVAEELTLTPEQLSTRHVGKQDPKRHLEEHVTKSLEQSTVQMLGMGVLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A8</accession>
    <name>I4Y8A8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_40159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959688.1">
        <property type="nucleotide sequence ID" value="XM_006959626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A8"/>
    <dbReference type="FunCoup" id="I4Y8A8">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8A8"/>
    <dbReference type="GeneID" id="18472155"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40159"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034001_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y8A8"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="45663" checksum="76265ECE00A2F4E2" modified="2012-09-05" version="1">MKVLTLNVWGLNNVSKYRQQRIKAIISKLSNSDADVVCLQELWLDSDYKLVERNLKNVYPYTKYFYSGLVGSGLAILSKYKIIESDFNAFKMNGPPLEVIKGDWMAGKGAGTITVQVPEIGLVDIYTTHFHAAYAENDKHARFAHRLSQSWQLATLVKKSYNSGRNVIVTGDINSEPFTLVFDLLKTHANLIDCWSVDHPTNDKIPPHSPSDAVFRCGYTADVALNTFHHQRYPGYASGDESSKFAGGKRLDYILLKSQVLKPVKSEIVFHELCGQNFEHSYSDHFGVMTTFECNEQPESPAKSRATDNEMCYLETIRKLRTLNKHSKNQSVKYIFFTALLVVLGLALVVASEFPPVASYSPLFTFFAFLAGAGGATYLYVGYIFGKFERHNIKNLIGQIEDHVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8H2</accession>
    <name>I4Y8H2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_47942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959752.1">
        <property type="nucleotide sequence ID" value="XM_006959690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8H2"/>
    <dbReference type="FunCoup" id="I4Y8H2">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8H2"/>
    <dbReference type="GeneID" id="18472433"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47942"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y8H2"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="39959" checksum="0FCBB08E92AFBAF9" modified="2012-09-05" version="1">MGCLQSTEDAGKARNDSIEQQLKKDKANLRNEVKMLLLGAGESGKSTILKQMKLIHQGSYSPEERDAYREIIFSNTVQSMRVIIEAMEMMGIQLSNPALNSQSAQVILSLPAQIDIEMMTPQVFQAIGTLWSDSGVQQTFSKSREYQLNDSAQYYFDSIDRMASPQYLPTDQDVLRSRVKTTGITETTFKIGELTYKLFDVGGQRSERKKWIHCFENVTAIVFLVAISEYDQKLYEDESVNRMQEALTLFDSICNSRWFVRTSIILFLNKIDIFRQKLQVSPIKDYFSDYKGQNDYDSACDYILKRFVELNQSEVKQIYAHFTCATDTNQIKFVLSAINDIVIQTNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X9</accession>
    <name>I4Y8X9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959447.1">
        <property type="nucleotide sequence ID" value="XM_006959385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X9"/>
    <dbReference type="FunCoup" id="I4Y8X9">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8X9"/>
    <dbReference type="GeneID" id="18475642"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69788"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004415_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8X9"/>
    <dbReference type="OMA" id="TDSAVMD"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="845"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="786"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="100947" checksum="99742EDAD3EF9A43" modified="2012-09-05" version="1">MSILSTSPAKSFLNRKKHNSQSEIQISQSVQYHSSNKVNNKDFCNSFWGQDSSGTGFDILTNKIKSSAKTIDDLKLFWKERASIEDDYARKLAKLSRFLVGSNETGAIRDSLDTLSVELEQTSQNHFNLSQNMRRELEVPTSDWSNRMSNFKKTSLASIEKKYKVLQTQESYVDKAKAKYTDNCVSINTFTAQKSLLQGKDLERVDGKLDKAKSAVGANERDYINFVRALSDTRKRWEADWRLFCDQCQDEEEERIEFIKTNMWEYANEVSTVCVADDESCEKLRQALEQVDPDLDIEIFVDESMTGNTLPEQPTFVDFSRETQAPSPAPRYAAFHRNSVRPLDVPKEAPRALASNNQAPKQEVVAEKPPPPSPKKHTVIEEPKVQKAPPRDPKNDENKPFKVPQLPARSADRPAAPKKEDVAPPKPEKEEKSSESGDVDELAAALAQLRNAPPVTGNLRANVAAQAEKKPRSRPVSQQSASTQPALVPPGSQMPVNQNQNKMYQGLDASQIQALQIQQKYAPHTTPPFPAMMQRPASSQSTAGGPVEDVLTTYHQQLPHERSRRNSKMEQQSQGTTPQTVSPGPTNARPLSAMGRSPSREGFAGIGANGAGSRQPSPSISAASPQRSATPLGISLNASGEVAHDQKAEEWKEKRRSVSPSPTPAPVSQSNMMPAQQQQQMQQAQAYYQYQMMLAQQSQQQPQQAQQPQHPQAPNPYQQYQQYYPYPGQQQMPQQPYVMTNTPGPGYNPQFATSGTPAPMLNAYQQQQQRAPSPSPTPAYSMSVTPGPQQQPQQAPFVPSIQTQQLSQTPQPLSSASGTSQQQMYRQPSPGPTPRPISTSPAKEPVLFHVKALYDYQAQTAEEFDFKAGDVIAVFKTPEDGWWTGQLLNESRYVPGKTLFPSNFVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Z0</accession>
    <name>I4Y8Z0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006959396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Z0"/>
    <dbReference type="STRING" id="671144.I4Y8Z0"/>
    <dbReference type="GeneID" id="18471650"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33276"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022672_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Z0"/>
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    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697507" evidence="1">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="473" mass="53897" checksum="01687BE53692B0DD" modified="2012-09-05" version="1">MKIEGVLFTLALSGASVNANWFGSKPSSIEEWNTDQLQNWLKENKIKFSDKSNKDSLLKTVKKNWDTVAHRQQVILNDIKDETIDKWDESKIREYLLENGVVAPKSSVEELRILVKQLAGDVRSSALSAAAEATAHASSTYDASKDNAKDRLTYIHDYVLRELNDSKDFIYSSWNDNELRSFLEKKGIIRTKSQIKRDELLKGMRQYYAALADPVYDAWSDNYIRHWLESNGVIKTKSAKTRDDLLNLMKDNYYDAKSHVYNTWSDNQLRTWLVDHGYLKSRDEKTREEMLYLIGKYYTSSRDVVISSWRTSDLRDWAISHGLIKSDVQVKREELEKLAHAKYDKLTSTAAPYVSWTDARLRGWLRAYEPEVAKVAKTRDELLSEVRKRYVDSKGYSEIVYGEIMGWVNYGRSSIGCLYNYLTGSARSVAENAQEKADELGKSADIASKSAEAAASSASSLAAKASKAAKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9G8</accession>
    <name>I4Y9G8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_65280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959398.1">
        <property type="nucleotide sequence ID" value="XM_006959336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9G8"/>
    <dbReference type="GeneID" id="18475005"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65280"/>
    <dbReference type="HOGENOM" id="CLU_1797940_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9G8"/>
    <dbReference type="OMA" id="MGPKIDD"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16864" checksum="F01D33A80C473A02" modified="2012-09-05" version="1">MTGENKPQRNHDKKGFSVARRAGKGAYTGKASKIKEQLIQKAKVKKEYANILKKEGRKDESLPSRPSKPKMKVEEKTDKTTTKPIKDDKRKAQKQKSEPEQDQESQKSQQQQRKRKREQYSKNHQPNMKVRMEDMLEKVKKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H3</accession>
    <name>I4Y9H3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF498-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959403.1">
        <property type="nucleotide sequence ID" value="XM_006959341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H3"/>
    <dbReference type="STRING" id="671144.I4Y9H3"/>
    <dbReference type="GeneID" id="18474229"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60889"/>
    <dbReference type="eggNOG" id="KOG3363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074390_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y9H3"/>
    <dbReference type="OMA" id="VMDTWNA"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="19074" checksum="833CA28FE80DCE9B" modified="2012-09-05" version="1">MILPSLFRRTNGLSNNLRTFSTSLPKFETAGALTSVLSDTNALQIQSVGKSGVTFSDGKICKGPVMIIDNKVFLWKVPSPTAPFNWGDAIPKDAFKVFETLTPRPEILLLGTGKHMLPPPPSFNKYLNSLGIQVDVIDTKNACSTYNILVEEDRNVAAAIFPVDGYEWKNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I2</accession>
    <name>I4Y9I2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_20349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959319.1">
        <property type="nucleotide sequence ID" value="XM_006959257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I2"/>
    <dbReference type="FunCoup" id="I4Y9I2">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9I2"/>
    <dbReference type="GeneID" id="18470836"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20349"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033275_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y9I2"/>
    <dbReference type="OMA" id="IFYMKPR"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="57"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="216" mass="23899" checksum="C4F1247B6369D021" modified="2012-09-05" version="1">MAQTPAQQVLISPADRFGLLGLLNIIRMSSSDMGMLALGSDLTNLGLDLSSPTMLNSTFVSPFSDNNARDAATLEPEFTLPACYNVQPPPPAFTKVAEFHDETLFYIFYTHTKDVMQQVAAIELFNRNWRYHKDLGLWLTKETGSEPVQKTPMLERGSYIFFDPKSWEKIKREFVLVYDQLEERPAGGKLSNLTNETGSGGSVAASTVQAPTIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9S0</accession>
    <name>I4Y9S0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959245.1">
        <property type="nucleotide sequence ID" value="XM_006959183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9S0"/>
    <dbReference type="STRING" id="671144.I4Y9S0"/>
    <dbReference type="GeneID" id="18474989"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65132"/>
    <dbReference type="eggNOG" id="ENOG502QW31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036093_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9S0"/>
    <dbReference type="OMA" id="FRICIAG"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697740" description="Macrofage activating glyco protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="36436" checksum="2571E9894AE713E7" modified="2012-09-05" version="1">MQLLRTAAILSAAGFASAAWDANAPDVVASGTMGVTNPPAPTMGTDVNQSSEARLVSINSIDDFCFFGPKEAGKTIGDTEAEQVAWCTQPRNNARVIPDGTITSAHFVKTDAYVQVRAQGDFTKIGVQDGDYGGELDPHGATGDGNPVGGNITSNVSGSDVSYQEWMEFLSYNQVCIRACIAGNETFGTPVMCEHKLDEMGCDFVMPGSNDEGFDTCEGDVAYPPGVYPVDGGFSTFAQRFTGTYSIDGTPTVYTVGVTETPSAAAFTPSSSNCVTQSSIAANNVSVSGASSSSSSSAANPESSSSSGSSSDSGSGSSGESSTNNGATSANTDGGDSGASTFTGVATVSAVALAVLAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA23</accession>
    <name>I4YA23_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959078.1">
        <property type="nucleotide sequence ID" value="XM_006959016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA23"/>
    <dbReference type="GeneID" id="18475590"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69496"/>
    <dbReference type="eggNOG" id="ENOG502SDS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1385130_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA23"/>
    <dbReference type="OMA" id="HYTINAR"/>
    <dbReference type="OrthoDB" id="5541797at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22791" checksum="C21D6012A818E531" modified="2012-09-05" version="1">MLSKYHYKLTNIPSTATLNDIKRLIARSAKTNPLSADSNFQVAFYTSKFPNDTHRANVKFTNNQVRESFKRSLRVFDRLSLSTSQLKCTEITKDKDELNGLTHYQPSSHPGQTVLITGLPGRLIQHDIQNWLRSYHVDQSSNSSQEPITSLHIPSDKFNGTSKWLVRLNSISEAHRLVRNLHQTNWDNQFLIHAKITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA26</accession>
    <name>I4YA26_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_19787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959043.1">
        <property type="nucleotide sequence ID" value="XM_006958981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA26"/>
    <dbReference type="FunCoup" id="I4YA26">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="GeneID" id="18470811"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19787"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="InParanoid" id="I4YA26"/>
    <dbReference type="OMA" id="RSHVDMT"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="130" mass="13662" checksum="2FFEF3000B535926" modified="2012-09-05" version="1">MAGLKSIIALSLVLALGFLLVILSCALWGNWLPLLSAFLFAFAPLPNSIASRCGSYSYSSYDEPNTALQDFARFFTSITLVTGAALPLVLAHAGILATTSSIMSVIGGALIYITIIAFGSSFQSGESDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA49</accession>
    <name>I4YA49_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex I-B15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959103.1">
        <property type="nucleotide sequence ID" value="XM_006959041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA49"/>
    <dbReference type="STRING" id="671144.I4YA49"/>
    <dbReference type="GeneID" id="18474980"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65001"/>
    <dbReference type="eggNOG" id="ENOG502S8RT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183941_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA49"/>
    <dbReference type="OMA" id="TMYQRFR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10463" checksum="6D327294A16B3298" modified="2012-09-05" version="1">MGGHGDFHTVKLDPAVERWNYMREHTYHHFKMTRPIANKILAFGLVIPAGIFAIAQYTDERWNFAGARKNELTTQRGTFINTKPAEAEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA89</accession>
    <name>I4YA89_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucraseferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959140.1">
        <property type="nucleotide sequence ID" value="XM_006959078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA89"/>
    <dbReference type="STRING" id="671144.I4YA89"/>
    <dbReference type="GeneID" id="18474139"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60750"/>
    <dbReference type="eggNOG" id="ENOG502QT0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048934_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA89"/>
    <dbReference type="OMA" id="VHPESQL"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45659" checksum="D5E4DCCFF7E83C9B" modified="2012-09-05" version="1">MSIVVDSQERTVIMSGFLKRTISGIGNKPANKQSDKNKESLSSAKVPISEVDCHSCVAKCDGETGDFEDFPKNFDIDTTSNMLGTYKPFSKQVVISTGRTDWEHDITDNELTLAGMLDRTQDTFQLKDDPGLMQRIIAKRANTSVQKVPQVASHPIKCEGVFDTRIEGNNNIQILNGSHISPSTKKERESALVFPDYVLAENICVNRETAEDFFKSHLAVNHLVASEKAIRTYPLPYIATVLICSHKSRDKKCAISAPIIEREMIKCVESEGWNIDKRGDTISLDHKPVQLPQGGFSMTATPYTSPQIKASPEECDTTKDVNEITERLKDITVEEGSTVGLFKVSHVGGHKFAGNVIIHFPSGASVCYGRVSAREVPAIVQQTIKHGRVLPELLRGGGNICRRDPQKSLREFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAL5</accession>
    <name>I4YAL5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_46864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958993.1">
        <property type="nucleotide sequence ID" value="XM_006958931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAL5"/>
    <dbReference type="FunCoup" id="I4YAL5">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAL5"/>
    <dbReference type="GeneID" id="18472403"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46864"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_3_1_1"/>
    <dbReference type="InParanoid" id="I4YAL5"/>
    <dbReference type="OMA" id="GGCKWQH"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="537" mass="60465" checksum="5499112362E4D329" modified="2012-09-05" version="1">MLSRLTRSLGFRIMSSPVHKKAKLEVSIEQPVVQKKPQQPKKDKAQKQAEKYAKLQKKSKLQSVERGGPEENIFLDVRHLLGDAVVDTHIKEESCFAAKYDFGTELELEISQMSSSGDGLAITECKSWVVAVPFCLPGERILARVYRNSYCHSYADLVKVLDKRDSWRDDEQIKCRYFGSCSGCQYQMIPYERQLLLKQRVVEKAYERFSHLAPELIPSILPTIASPKQYNYRTKITPHFQAAPKNAGDDYDAKIGFDMKGRRSTIDIEECPIATETLNVGMKPARANVKATIKNYKRGATLLLRDSMVRPADAASATSVDIPPVDLSTIKPDERTCITDHKQITREIVGDKLFEFTAGSFFQNNSSILVPLTQYVLEALPEKKKDPMYLVDTYCGAGLFSICLQERFDKVAGIEISEQSISYAKHNVKLNGLDDSKISFRVGRSEAIFDVVKDFPAENTSVIIDPPRKGCDEPFISQLKQFRPHRVVYVSCNVHTQARDVGMLCGEDGPYSIESLRGFDLFPQTSHVEGVAVLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAN1</accession>
    <name>I4YAN1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_29226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959009.1">
        <property type="nucleotide sequence ID" value="XM_006958947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAN1"/>
    <dbReference type="STRING" id="671144.I4YAN1"/>
    <dbReference type="GeneID" id="18471089"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29226"/>
    <dbReference type="eggNOG" id="ENOG502SGX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538843_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAN1"/>
    <dbReference type="OMA" id="IFNHRRS"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="56197" checksum="A91CB8FD60C804CF" modified="2012-09-05" version="1">MNLPSINSASFTHLRLFQSQQSSPAVPQQSPATATAQQHTKKDGNESSGRFPDKLFHLLENPDLHNVISWSEDGKYVLIHDPVELEKVMGTMWRSSAYPTFQRQMNIYGFSRTSTIKRNKPGQANRMMPSTWSHPTISRGSTAGDLAKIERNAPRRDRKSKKSDYSRSYDDDDEDTIKQRSRNSTTLTPALHNVSLPAIESETPLDTRKHLQNDDGDHPPAKRARRPSATLSRSAPSATAMTRNLSMTSNYSNSVGVRSSRRLASSVPREKSNSNAFSQMRSPNKSDIFSDDEPEMAVLLPQIEDEIEEEDDVVHGKYNKNDSASGEELSSDESDDEDEPRRQFSSSLGLRTPFGTNSSKVSSNSLDILAAAAATRNPIPSISRRSSNFLSMNPIGVGARRQFNNLHEQEPSSFDSDYSIFSQRKSSYKDSFLRSQPTTNVAPDSSDGESLDEEALFTPPNVAAANYRPPALDTLSNVAANNLKKETDKTRKLSFLPSFNFFSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAQ4</accession>
    <name>I4YAQ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959032.1">
        <property type="nucleotide sequence ID" value="XM_006958970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAQ4"/>
    <dbReference type="STRING" id="671144.I4YAQ4"/>
    <dbReference type="GeneID" id="18474102"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60691"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="InParanoid" id="I4YAQ4"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="499" mass="56313" checksum="874BCCC654FFAB5C" modified="2012-09-05" version="1">MDTEMKDFDDLVNDDKYEMGTGQELARAELQATEDMFERRRVLRTLAVPTDDNKVRERLRAFGLPMTLFGERPEDRRSRLKSMIADMQEEAGEKAKIESEDESEEEEEFYTVGSQELLQTRRLLAEYSIPRAKRRIEKERDDWAKPLKSIVDARKRTFEYIKSFNVLGSQVGDSRPISQVKFSPDSQLLATGSWTGNIKLWDIPNCNHQMTLRGHDGLVGGVDWHPQATLNQSKSTVNLASGSQDSTVALWSLEKDTPLATLKGHTHQVRRVAFHPSGRYLGSASFDETWRLWDVETQAELQLQEGHSKEVYALAFQDDGALVGSAGMDAIGRVWDLRTGRTAMVLDGHADKILALDFSPNGYQCATGSGDGKIMIWDLRALKSISTMPAHNISVGDLKFYRQPERVLNSRNDKQDVKMDESGDNEDMSPLVKEPYSHGLFLASAGFDGYTKLWSADDWICQRSIAENSKIMSVDVSRNGKHLATGEWSRSFKLFGTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAQ9</accession>
    <name>I4YAQ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959037.1">
        <property type="nucleotide sequence ID" value="XM_006958975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAQ9"/>
    <dbReference type="FunCoup" id="I4YAQ9">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAQ9"/>
    <dbReference type="GeneID" id="18471604"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33009"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075696_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAQ9"/>
    <dbReference type="OMA" id="IQKNHFR"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="209" mass="23794" checksum="B4161832838A7E7E" modified="2012-09-05" version="1">MGFAHNNVLHRNHFRKDWQSRVKTWFNQPGKKKSRRVTREKKAAALGVRPLENLRPAVRCPTIRYNRKLRAGKGFSLAELKAAGIRRKEALSIGIPVDHRRRNLSEEGLKINVDRLTAYKARLIVFPRNAKKPAKTDSKDLDAQVTRDVNAAIPIPAGTVAEAPRKITDAERETNAYRTLRNERATARYDGARKVRAAKKAEEEEAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT7</accession>
    <name>I4YAT7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958762.1">
        <property type="nucleotide sequence ID" value="XM_006958700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT7"/>
    <dbReference type="FunCoup" id="I4YAT7">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAT7"/>
    <dbReference type="GeneID" id="18471568"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32831"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAT7"/>
    <dbReference type="OMA" id="FNRQWPW"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="459" mass="52455" checksum="20FE5748AE912BDA" modified="2012-09-05" version="1">MGIRTAVESYDATGSLLGLTFGRLISRDGVVLAISDAVLVCSTSISFVFIKAIQHGWIRYNVIGLTIQHIVQVFFLAIPVFWSCQRNWPWVQSGFLTLHSLTMIMKIHSYMATNGYFANVLGQIKSLEAQLANLNASALKASDEQKVAQDEEKSGDLKKRKPFSNVKEEENETNNGVSTPLGSNEIETADVKDVSEHPLTHAPNPDIAKVASEINELKSHITSQGPSKISYPNNVTFGNFLDYLLVPTLVYELEYPRTEKVRLWYVIEKTLATFGTFYILYVISEHYISPKMPRPEESFARTWLDLCIPFLCNYVLLFYIIFECICNAFAELTRFADREFYQDWWNATTWDQFARKWNKPVHMFLLRHVYVSTISTYKISKQSATLLTFLLSALVHELVMAVVTKKIRMYLFMLQMAQLPMIAIGRLPVVRRYPAFANMFFWLGLMSGPPLLAVGYMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAV1</accession>
    <name>I4YAV1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_46472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958774.1">
        <property type="nucleotide sequence ID" value="XM_006958712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAV1"/>
    <dbReference type="FunCoup" id="I4YAV1">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAV1"/>
    <dbReference type="GeneID" id="18472385"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46472"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAV1"/>
    <dbReference type="OMA" id="AICVQNV"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="129"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="265" mass="29039" checksum="94A49C813E46D322" modified="2012-09-05" version="1">MPKAGTGKKPAPAPYSKAKATKKVTNPLFESQPKSFGIGQDILPKTDLTRFVKWPEYVRLQRQKVILNQRLKVPPAIGQFSNTLDKNTATQAFKLMNKYRPESKVEKKARLQQAAAAKAEGKEAAASEKPLFVKYGLNHVTALIEAKKANLVLIADDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHKKTAAVVAIQDVRAEDQQDLAALVKACNANFVEKYEQHRKTWTGAQRGGKSIAKLTKRAKAAGQDVSKVSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAV2</accession>
    <name>I4YAV2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958775.1">
        <property type="nucleotide sequence ID" value="XM_006958713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAV2"/>
    <dbReference type="FunCoup" id="I4YAV2">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAV2"/>
    <dbReference type="GeneID" id="18474037"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60575"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_1_3_1"/>
    <dbReference type="InParanoid" id="I4YAV2"/>
    <dbReference type="OMA" id="FCEHHFL"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="83"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="267" mass="29981" checksum="C1B3A901FB7D944F" modified="2012-09-05" version="1">MDSDNDMQQTTHELSQMNIELQNKKLSRPHPLSKQPSRASSLDTRTSTPVADINGLGWPAKATLQRLKESPEQKEVRTAKLTGAVKTLLECIGEDPMREGLLKTPERYAKALLFLTKGYEEKLSDVLNEAVFEEDHEEMVIVRDIDVFSLCEHHLVPFNGRISIGYIPNRKVLGLSKLARLAETFGRRLQVQERMTRQIALAIEEAIQPQGVAVVMEASHMCMVMRGVQKASASTVTSTMLGCFRTSAKTREEFLTLIRTPKATIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAW7</accession>
    <name>I4YAW7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_19450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40s ribosomal protein s9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="195" mass="22261" checksum="85DAB4378453058C" modified="2012-09-05" version="1">MPRAPVNHSKTYKVPRRPFESARLDAELKLAGEYGLRNKREIWRIAFTLSKIRRAARELLKLDEKDPKRLFEGNALIRRLVRIGVLDESRMRLDYVLALKIEDFLERRLQTVVFKAGLAKSIHHARVLIVQRHVSVANQIVNVPSFTVRLDSQRYVDFSATSPYGGGREGRVKRKRARAAAAAEGGDDAAEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAW9</accession>
    <name>I4YAW9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958788.1">
        <property type="nucleotide sequence ID" value="XM_006958726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAW9"/>
    <dbReference type="FunCoup" id="I4YAW9">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAW9"/>
    <dbReference type="GeneID" id="18475559"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69265"/>
    <dbReference type="eggNOG" id="ENOG502S7Q8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281772_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAW9"/>
    <dbReference type="OMA" id="HGFLTQT"/>
    <dbReference type="OrthoDB" id="3361281at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="2">
        <location>
            <begin position="752"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
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        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
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            <begin position="115"/>
            <end position="124"/>
        </location>
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            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
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            <begin position="190"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="618"/>
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        <location>
            <begin position="632"/>
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        </location>
    </feature>
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        <location>
            <begin position="648"/>
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        </location>
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        <location>
            <begin position="662"/>
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        </location>
    </feature>
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            <begin position="689"/>
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        </location>
    </feature>
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        <location>
            <begin position="799"/>
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        </location>
    </feature>
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        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
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        <location>
            <begin position="952"/>
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        </location>
    </feature>
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        <location>
            <begin position="1043"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125725" checksum="60DAD754938BCCC3" modified="2012-09-05" version="1">MRENDASENVGDEIELSPKRNVVRKYGRARPEETDRQPSPTIAIEKPTVEETNLLSDDGTNEKDEKDEHAELRRELGLGGWNDEVDAIDTMPEEQLRSLPANLLDEFDSDPEENTESHFSRSKDQEEDYSLSMAEKRKIEEKQPAVELGEANDDIILMDANTVPSHQPLPFEEDDMDEIPTKTKKPKGMNKKDVDELHRETARMVREQNIRLESRNTKMTLADYYAKLAIKRGHAENKAEEILHDDKEQPAESTILTNSKEEPKEHSKMNKPEETPDSLTQQDLNQKKKEQSEKLKLLKLRALKNTRKQKSPEVDVNKDDDDIEILADENPAVGPLARAAGARLGAGKEDASSKLAAKRRWDSREAHRIRKFVGISERGKSGAKRRRSSEGTPNKKGKLLTNEELMENIRQKALNQELEFKNETEVLGRSRKNKYHIPKPKTELAERVDPIEVALKRAAKRAEDDYDAADDEGDSEDDPEDGNWLGSAEEDNNENENNENDANHNDSEADSEEPDENEKEKENHSSFSSNATSSRLGNTRKPLGEAAGHAYDNMSDSDSEPRGYRRIRRIINDVNEDNQEDDSQVSNRLESPFAGDLQPEFYMNKDGLLTQSKPQTEFSDEDIIMDDDDGPRQNNLLKRNSYNSDNEVEARPIRERRPIDGTQQTEQTEQTQKQSTQATQAATQIETQFDNQAQRMSPTQAETIPNIKESTQSVERKTLTQPKSAFDTLKVGMKKQEAKIQQKKSGAPIDPRFFEAQAEESDEENLMGLISEDEEEDDGVDRHLEELVNDERVAKELREKQDKLATEKYQEQRQQDDELDKKVAQNAVDGRYRYRRRHRTEDGLDMSSDDDDIEFMKAQEQLAARMEKKRRKHAGEEPMDVIARNPRTAAFAAAFEAPANADDFEAEFDVEHTGGALIEQPEETNQGIISDDDGEDSDNSDTSAAAPQKHSTLKEETEAMRRFMEKKHAFNNTYSSDSEDESQAMQYVRKGDPGKQKRKPQATSHHNNDDDEVVTSYTQGRKPLSPRSLSKLKKFAQDEGTGANFNPNGATKSGVTSFLADSNRSQGKQDKGGKKKSKPSSQNSSQKSQQPSSQSSQSKPASKLSSFGKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB74</accession>
    <name>I4YB74_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_46694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958888.1">
        <property type="nucleotide sequence ID" value="XM_006958826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB74"/>
    <dbReference type="FunCoup" id="I4YB74">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB74"/>
    <dbReference type="GeneID" id="18472395"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46694"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_3_1"/>
    <dbReference type="InParanoid" id="I4YB74"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="10334" checksum="B53CDB91F607128B" modified="2012-09-05" version="1">MSVQPVNPRPFLNDLTGKAVQVRLKWGLDYKGYLVSVDNYMNLQLANTEEFQNDKSNGALGEVFIRCNNVLWLKQSDDVPNQAKEEEMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB76</accession>
    <name>I4YB76_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958890.1">
        <property type="nucleotide sequence ID" value="XM_006958828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB76"/>
    <dbReference type="STRING" id="671144.I4YB76"/>
    <dbReference type="GeneID" id="18472951"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57778"/>
    <dbReference type="eggNOG" id="KOG1882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022457_1_1_1"/>
    <dbReference type="InParanoid" id="I4YB76"/>
    <dbReference type="OMA" id="KIPTANW"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="28682" checksum="CA95C78F1E27ADB6" modified="2012-09-05" version="1">MSSSKSYAEGSGRGRKFDNDRDDRDNYKNNREYERRHREDRPRGSNRGRESYEDRKPYRSKYDDRKPYDDRKPSYNELNRRSQSPHQETPDFKPNFANSGLLAAESKTVNGTVLKYHEPLEAHKPDKKDDWRIFVFEDESQTDMLTLDKQSCYLFGRDTNVADYPIVDASISKQHAVIQFRMLRSKNEFGDVSEQVKPFILDLESTNGTHVNGKEIPVSRFYEVMAGDVLQFGLDKREFVVIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB83</accession>
    <name>I4YB83_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958897.1">
        <property type="nucleotide sequence ID" value="XM_006958835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB83"/>
    <dbReference type="STRING" id="671144.I4YB83"/>
    <dbReference type="GeneID" id="18474955"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64777"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032490_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB83"/>
    <dbReference type="OMA" id="WISTTHV"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="119"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="48221" checksum="05096566D4828391" modified="2012-09-05" version="1">MIQERRTLGQTVVFDDIPSERIEQRVSPLSGYRSKRHIYNAAYPRTLDGSTTIYPKRSIPHPNESKAEKGTRISSELDEIVSARVKAGDKESMEVNGERIYCVIERLVHEKARGDGLTLILCHSNGFVKETWDATLEELIKQPGHPIDEIYLFECVNHGQSFLLNASKLGLVFDWSDFSRDILTFLTYYLPQTFTSEDLPTKLPLQHTRTGPWKNFESTRKITPIGHSLGGTSLALAYAEAPKLFGPDGSLILIDPIIRIPEHPLEFKAGVQLKTGLKTQIPAQLALKRRDRWATKEEAFKTMTKSALFSQFDKRALQAYVEYGTMEDEDGNVTLVTDKLQEAAVFADDLAFFEGSSAIAELSTKIKVLVVLASKPGPITAVRDEKEKEAIFKGTQVEEINSGHLIVQEVPNKLSKVINNFINNKLSCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC7</accession>
    <name>I4YBC7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958622.1">
        <property type="nucleotide sequence ID" value="XM_006958560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC7"/>
    <dbReference type="STRING" id="671144.I4YBC7"/>
    <dbReference type="GeneID" id="18473987"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60499"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009189_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBC7"/>
    <dbReference type="OMA" id="VKSNPPH"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="451"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="952" mass="103408" checksum="EEACCB3E5E31CD8C" modified="2012-09-05" version="1">MTESITPEQHNTENTSSTHQEATSSLPTYAMYQRKPHTISATSLSVEASSSAGQGKDATHRLQIQQLRASAQNLGLPSDSVGYKILEALATAPPSDEDISWQDVLKLASSDKATLLLPNIPSSFSIPIKPSLIRNHIIFTLNAPHGASASPFKQQAQMLVTNGLRGSLDEEKLVFHGHLSQNYLNSNLFDSNTRAALLNNLTPMTNHVGFETEFPTHKCFITSTLTIPTPPIPKQTARSRSSSLTNAAKNQSKSTFATFFGGGDRRTSFLSPSSLSDVARNESEYEYGPPVEVNVRTIDASVNYDDVKRSLIKSVMNRIRERLEGLPSKAIDRVVQFVVQFYPDTPSSATLLAKRAPSKKLGMVTPNLSDPDVSTAVIQELYIKVRDEVSSLSWNEQLAQKENAGEIITEREKETLEEAVEDEASLAVERVESVVTTEIFDLLYVPNNAEIIRNDTLSSRIAALNMLDLNLNHLGVQVPDAPLNGQDENEAEADARKGLEAVVNDCGQELQKIGGCLSPAEKVDILVQAHKNIVDGLAVLPPIRLRPEGDNQESDSAKDEESKDREREDKSKPTSSADLILPLLIFSMVKSNPTQMVSNLLFIQRFRAEGLMSGEASYALVNATAAVEFLSSVDLSELGLGGSDRIIGFGEDIAQSSLPLRPVQVESDELSSKIRSKVTAEIGDLAGSANKVLSGVVDSGWGALRGLIDRNEDNIPPPTIIKTADELTSSPVNSRPQNLFNRRTSSISVASIAANVANIASGKDTKPRLNTFPDASSDDRELMNIPNSATTGNPSKDMPVSQSLDFQHKRNDSDARSVKSMSSFKSNNSNREESLGERMNIANRLASIPGLGRLSISQGSPTKSQEATLSVSPSQNSLLNSIFPFKPGHSRTQSYNSQLAAYEPPSSHFLNANADDLKVSEVKALLSDYKRLAGVVESLQTLLAQQQQPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBU9</accession>
    <name>I4YBU9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958471.1">
        <property type="nucleotide sequence ID" value="XM_006958409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBU9"/>
    <dbReference type="GeneID" id="18473943"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60434"/>
    <dbReference type="eggNOG" id="ENOG502S4RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086662_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBU9"/>
    <dbReference type="OMA" id="AWDHDSW"/>
    <dbReference type="OrthoDB" id="3352285at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="256" mass="28921" checksum="59B766C775C18798" modified="2012-09-05" version="1">MQRMNNSFNHSLRPLAIFVSFVGLIYCVVRGASLLKDSTDSASELRTADIALGAIYLGLSVFELFGIIVAVKKSPRTVALYAKSIIGAGFIISSLEIAALIVHIKLKSESIDHCKNRLSDEDDQTRVDDFCNDDWSRGVWVHAIWMAVIIVLAIIFIGLWWRYKNQLQNNAYHVPKENEPQQPQAYPLQANLRYAPTLSYAPSRNQPDYVPPYPTDAAPPYDAKDYREDKEFQDVPFHNDASSSNLNLNRQNHHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC18</accession>
    <name>I4YC18_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">WALSEDRAFT_51505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958538.1">
        <property type="nucleotide sequence ID" value="XM_006958476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC18"/>
    <dbReference type="STRING" id="671144.I4YC18"/>
    <dbReference type="GeneID" id="18472561"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51505"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC18"/>
    <dbReference type="OMA" id="FYQHKGG"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="20464" checksum="B061C98CE8BF6F7D" modified="2012-09-05" version="1">MLSPPINIKKWVEENKDKLKPPVNNFCAYSGQDNIVMLVGGPNARNDYHLNETEEWFYQYKGSMCLKVVDSGEFRDIIIEEGSMFLLPPNVPHNPVRFADTIGVVIERVRPGESIDRLRWYCRDSSHITTENPHGGYIIREEAFHVTDLGTQLKPLINNWMSNESLRKCLGCGKTADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC53</accession>
    <name>I4YC53_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_38556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958567.1">
        <property type="nucleotide sequence ID" value="XM_006958505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC53"/>
    <dbReference type="FunCoup" id="I4YC53">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC53"/>
    <dbReference type="GeneID" id="18472071"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38556"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="I4YC53"/>
    <dbReference type="OMA" id="MNMFSNA"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="426" mass="47529" checksum="697606AA072E8CE2" modified="2012-09-05" version="1">MKEDLGMAQGDLSNIVSTYTAGYCLAQIPSTLMLLVIRPSYWFPLNGVGWAILTCCCAVAKNSNTIYAIRFLQGMFESVAFSGAMFVLGSWYKPEELTKRTALFCISGHLGSVSASLIQSAIHSNLNGVTSLATWQLMFVIDGVIVFPVVVYGFLCFPDLPNSTKAWYLTQEERELAVNRLPPSFDVSFTPEASKETFKRTVGNWHIYVLTLLFAVGNLPEGYGMNNAMSLWLKGLDYSVTDANNYGTGVYGVAAFTTLLASYIADKWSCHWVLVCFMGVLDLVTSIIIVIYPRNMGVLYFAFYLSGTAYLGQSVIFSWANIICKRDPVERLIVLTSMNLLSFIFNIWWNVTAFSSQYAIEEEYTPYNPAAIGCIASVGIYIPMTFLTLYLHRKQNRTDEVAEIIDKVKSVTSYSIDKDDLEKSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC87</accession>
    <name>I4YC87_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_38128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958276.1">
        <property type="nucleotide sequence ID" value="XM_006958214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC87"/>
    <dbReference type="FunCoup" id="I4YC87">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC87"/>
    <dbReference type="GeneID" id="18472047"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38128"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="I4YC87"/>
    <dbReference type="OMA" id="KFIMRNA"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="458" mass="51965" checksum="2FD3692C81FFBEAB" modified="2012-09-05" version="1">MDKYDLKERLGVGSFGVVYKAVNRTNDEIVAIKIIDLEQTDEDILHIQQEIQHLAACQSDYVTKYYASFVDGFKLWIVMELAVGSCLDVIKHKVQIRQEQVATICKELLKGLEYLHSEGKIHRDIKAANVLLSETGEVKLADFGVAAQICERMSKRNTFVGTPFWMAPEVIQQTGYDMRADIWSLGITAIELATGLPPLSDFHPLRVLFLIPKSAPPELEGDHFSDSFKDFVKECLTKDFQRRPTATELLEHPFIATAHDTSILNPLIDTLTTGVPSAKNSPNADNDDEDSVKSLIDEWNWSFGTLKANEIGKANHVARSEISQTDMARKYAAIDSDMSNNRTIFRKGSSDISYAPERTWNRPSTPAEQKPDENIDKHLKHLDKMMDDTFKPKEIASIMMLKNGYRELHDLNSNLYKQTIYHNGSAQQEAKPLPYKTNEISAMLFDRWTETITQKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC90</accession>
    <name>I4YC90_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_32497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958279.1">
        <property type="nucleotide sequence ID" value="XM_006958217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC90"/>
    <dbReference type="FunCoup" id="I4YC90">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC90"/>
    <dbReference type="GeneID" id="18471501"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32497"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_1"/>
    <dbReference type="InParanoid" id="I4YC90"/>
    <dbReference type="OMA" id="LFWESHD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="8">
        <location>
            <begin position="35"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="23316" checksum="38BDC693D3CB103F" modified="2012-09-05" version="1">MSRKVEPTIQIARDALNNRLQKVIDKPDPQPETSIFANGCFWGTEELFRKYFKSAIINAEVGFIGGDDNGVGKDPSYKLVCTGQTGHAEALSLTWDNRQASYEELLDFFFRTHDPTQVDRQGADIGTQYRTALYPTTDDQFSIANRIRDQVQETHFTPKSSTIATVIHPVNKYKWWKAEDYHQQYLLNNPDGYQCYTHRLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCF0</accession>
    <name>I4YCF0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958336.1">
        <property type="nucleotide sequence ID" value="XM_006958274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCF0"/>
    <dbReference type="STRING" id="671144.I4YCF0"/>
    <dbReference type="GeneID" id="18475487"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68902"/>
    <dbReference type="HOGENOM" id="CLU_943991_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCF0"/>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF77">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32758" checksum="4898069B301F4FE2" modified="2012-09-05" version="1">MFDKLTYKFNIDQSIEHSTDIPILWLYGRSSISFEPECLKWQIYLLFNNINFSLKTINEPKASPNNKLPLLELPHKPSQRAVLLKDDEIRKYVENIQDIPEADTTELDILELVEKQLRSSFLTYFFFMPSTSEQASKLYFPESNDTALVSVQRSHKFSRLKAALSVEIAKVVNGTDKLENASTTLTSLILSRYFPSDMPYESVQIDVDVVDRIAASTLATLSSKLGSNTWILGKDKPSFADATLFAYLYLTLSLLPPSSHLRRRLTGHINLTHYTQHIASDYLKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG2</accession>
    <name>I4YCG2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UEV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_68912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958346.1">
        <property type="nucleotide sequence ID" value="XM_006958284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG2"/>
    <dbReference type="STRING" id="671144.I4YCG2"/>
    <dbReference type="GeneID" id="18475490"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68912"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCG2"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="427" mass="47879" checksum="3056142ECB4FC98F" modified="2012-09-05" version="1">MMISTIVSDWLKQVTSHYKHRERVFNDVSNLLASYQTLSPRTEVYIHDNGVSELLLNLHGVLPIHYRGVQYNIPISFWIPHNYPEIAPWVYVVPTSSMLVKSGNGVDASGLINLDYVKNWHKKPEAFNLVDLSLVLRNSFEINPPLYAKSTETQQQQQTQGAQTGQTTPSRPHKPPSISLSQSSTPSTSRVDSPPRRPPPPHSINQISSPVKNVVTSDTADLLTTEPNSIPHTANTIPDEIKPAPTRPLNPNTVKLHATIHAIFSQKVSQSLENHGNLYNSQLTLKSDLERAKDVINDEQSRLKSVNEICKSVALKVNETTEQGLSVLENGRRKGEIGVDEIVCGDNLVANQLVDLIAEDRAIEDTMYHLGRALNAGRVDLERALRTIRELSREQFFKRALIKKIQNGLESRSDYMVNSDQNESFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG3</accession>
    <name>I4YCG3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_18512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958244.1">
        <property type="nucleotide sequence ID" value="XM_006958182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG3"/>
    <dbReference type="STRING" id="671144.I4YCG3"/>
    <dbReference type="GeneID" id="18470772"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18512"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002329_2_1_1"/>
    <dbReference type="InParanoid" id="I4YCG3"/>
    <dbReference type="OMA" id="KPYINYV"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="634" mass="71587" checksum="2EC61CD7DF5BFC33" modified="2012-09-05" version="1">MAPNDKNKQSLLKPVWNLLGNLKSQIAQGKFFQDVGVLHDLLKTAANGGAQNDREFLLERMVGILSTIPSTPENDRLTGKFIQMLWQDLPHPPLNYVGDVPFNGNEHVSGSLRIRHADGSLNNPFLPSLGKANTPYARNVALKHVYTQPLPSEEDVFNKLLRRKEGDFLAHPTGLSSLFFNFATCVIHTIFRTDTKNSAVNGTSSYMDLAIVYGNNVEEEHSVRSFENGHLKPDTISESRLFMMPPAITTLLILLNRNHNYICENIFRENEKKWYKPWAELDDENKKKQDEDIFHTAKLINCGFFANIVLHDYLRAILGLTRSKSTWVLDPRAEVHNMGQPPLETGTGGAVSIEFNVLYRWHSVLSKSDTEWTENFFKKMFGDDVDFDKITPREFGQKAYGLIQASGNEPSERNIPGLSRQENGTFKNEDLVGVLKQAIDEPAGSFRARGTPSVLRVVDIMGMKQAREVWGLCTMNEFRKAMSLTQFKSFEEWNSDKEVAQAARELYGHIDNLELYPGLLAEEQKPPIEGSGLCPGYTVSRAILSDAVSLVRGDRFLTNECTPQALTTWGYNYIQPDNSNKAFGGMLVTLLENTLPNTLDKDSVYALFPFNTPETMKKNLTKLKIEKEYKFTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCI5</accession>
    <name>I4YCI5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_32562</name>
        <name evidence="14" type="ORF">WALSEDRAFT_33863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="15">CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958364.1">
        <property type="nucleotide sequence ID" value="XM_006958302.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960239.1">
        <property type="nucleotide sequence ID" value="XM_006960177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCI5"/>
    <dbReference type="FunCoup" id="I4YCI5">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCI5"/>
    <dbReference type="GeneID" id="18471518"/>
    <dbReference type="GeneID" id="18471761"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32562"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33863"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="OMA" id="ANEMFIN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="14795" checksum="EDA3B1838AC4EC54" modified="2012-09-05" version="1">MSQQVGGKSGGKSGGKAGALDAGRSRSSKAGLQFPVGRIHRHLKNGNYAQRIGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDDELNKLLGHVTISQGGVIPNIHTELLPSKTKKGEGIDSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ2</accession>
    <name>I4YCJ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958371.1">
        <property type="nucleotide sequence ID" value="XM_006958309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ2"/>
    <dbReference type="STRING" id="671144.I4YCJ2"/>
    <dbReference type="GeneID" id="18475494"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68938"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_928141_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCJ2"/>
    <dbReference type="OMA" id="QPEWEGK"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="300" mass="33688" checksum="D5B35FE2CE7128FF" modified="2012-09-05" version="1">MAYNNNNATVLLVGSTGFVGGRILNELIQAKHNNKIGKVIAGVNHATHLANVDQTIQLDYHDDENLNQQLKDVDVVISAISITPDSLTNVDKLLTAMAFNKVKLYIPSEYGVDYNKTQYKSHPVFVAKSRHIEKAKQFDFKTVSIYSGLIMEFTFGKLLDMKELEWKLVSSKQKVALTSLNDLSSVIAQLAATPLEDVNKLKSELRVFSDCRSIHKYARVFEDQIHQPIVLIDVNRAIYEKTFALLEKGEYTGDQFEAFKATVHLIASEGSVDFTADNDNGMFEIDWTTVDKYAAFICHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN6</accession>
    <name>I4YCN6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958039.1">
        <property type="nucleotide sequence ID" value="XM_006957977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN6"/>
    <dbReference type="GeneID" id="18473817"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60216"/>
    <dbReference type="HOGENOM" id="CLU_2851433_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCN6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="65" mass="7782" checksum="3D0D28C0DC001B2C" modified="2012-09-05" version="1">MVFCSDATRLTRNYDDRSFLKEVFSSKALFVLIDDDVKQVVFDDLDNIQFPRKRQSIMIYWTAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCS6</accession>
    <name>I4YCS6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_68696</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958076.1">
        <property type="nucleotide sequence ID" value="XM_006958014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCS6"/>
    <dbReference type="STRING" id="671144.I4YCS6"/>
    <dbReference type="GeneID" id="18475455"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68696"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003589_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCS6"/>
    <dbReference type="OMA" id="RRWECKT"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="139"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="423"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="14">
        <location>
            <begin position="786"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM21768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="102822" checksum="6AE551DBFB272C4C" modified="2012-09-05" version="1">MYKQSNAYVRYIEPLDVDLARQVEYDMDEQDKEWLDDLNTFRAELHVEAVTYELFEIIIDRLEKEYLNLQKKLPASHTKAHFNEDSTCVICNDSECDNSNAIVFCDGCNLAVHQDCYGIPYIPEGQWLCRKCTVSPENPVSCVLCPNEGGAFKQTNSGAWAHVLCANWIPETGLANPVYQEPVEGIDKIPKSRWKLNCYICKEKMGACIQCDDRSCFVAMHPTCAKNFGLLCKTKNLPDDQTIIMRALCHRHRPKTIKSAPLFDADKDLTVIPMQVKSSTKAARAHSHNFNPGPPLCPQYVIERILDAIESIDISYKQEIVYEVTKYWALKREKRRGAGLIRRLHLEPWSATLSSQHSEADKRQKMEYMVSIKEDLERARQLVEKLLEREAAKHEQTNHVIETICNFFYPFDKQLRLVFEKIAALDTDDIFAEQVSTLDAPDYYEIIKHPRSWSFIYSKIDTKSYKHKDEFLADINLVYDNAMEYNMPDSFIYNAAQKQKELAKQILEESLSEITTFEQDSKVIEVLRDEQGIEKLYDTSLFQEPEQVEELVAKPSKRRRRASRAPKKSKRKNKPYDREEARVTLQERQQRQAVIADKQLKDIIDSGGGERSLRSSHRDLKPEEKDTSVEINRKEENIDVSEQQSEVTSPGKEAQKSPSKTFKKEKESQRVKKEESTAEPIDDVDNQENDLSTSTNLRRSKRRSSVTKEPQLSRESSLSVVPQSEEPEEGPQTKEADSKKRKGDTDHKGSSKPKKIAKKTKSKPRESTKSSGKRTAPPTRSTDFTSGSLVWAKLEKYPHFPSEIYDVDDEEDAEVVPDNVMKARPKSKFVIYLVKFFDSKRTWAWVPRHNIVSLGWDDVDQQYLERKLFKGVREWESTKAAYRRAMSSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCZ5</accession>
    <name>I4YCZ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958139.1">
        <property type="nucleotide sequence ID" value="XM_006958077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCZ5"/>
    <dbReference type="FunCoup" id="I4YCZ5">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCZ5"/>
    <dbReference type="GeneID" id="18473850"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60266"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="InParanoid" id="I4YCZ5"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="448" mass="50995" checksum="8046368A534FE9FB" modified="2012-09-05" version="1">MDNWRFAQCFGDKGDVEEVTEADIISTVEFDQTGDYLATGDKGGRVVLFERNQTKKGCEYKFHTEFQSHEPEFDYLKSLEIEEKINRIKWCKSSNNSHFLLSTNDKTIKLWKVFDKSLKVVSENNLSASHPSPPTSLTLPQITSAPHPSITKQLRLPRMSHHDTIVAAVPRKVYANAHAYHINSIAINSDGETYLSADDLRINLWNLGISDQSFNIVDIKPNSMEDLTEVITAADFHPIHCNLFMYSSSKGTIKLADMRDQALCDRHAKLYEEEEDPSNKSFFSEIISSISDVKFSKDGRYILSRDYLTLKIWDLNMDNKPLKTINIHDHLRTKLCELYENDCIFDKFECTFSGDGKQLMTGSYDNYLQIYNSNPDSSDDVVLQADKSAFKAKKIGGKGLAGLNNKDEMNLDNIDFNKKILHASWHPNEDTIAIGATNNLFLFSRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD20</accession>
    <name>I4YD20_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_60277</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958163.1">
        <property type="nucleotide sequence ID" value="XM_006958101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD20"/>
    <dbReference type="STRING" id="671144.I4YD20"/>
    <dbReference type="GeneID" id="18473858"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60277"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_2_2_1"/>
    <dbReference type="InParanoid" id="I4YD20"/>
    <dbReference type="OMA" id="ARWFKIA"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698011" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="26839" checksum="2CD3AC02348F8E07" modified="2012-09-05" version="1">MLKLLTLSSVLAAATAHGIVKQVIFDGVTYDGPYPNYGEEQEFKAQGPIRQVKNLDPITDIYSPDLACGRESLPSEYSAEVGAGAEIEFVWNGGDDGYPWPHQVGPLLTYMGNCYDDCNNVDPTTVDFFKISEQDMREDGQWEQASLVDFATAKSKIPGNIQPGNYIIRHEIIALHNANEVGGCEFYPSCTNVYVNSDGDSVPGDTVRFPGGYDPEEAGIYTPELYNQQEGITGYQQPGPGIYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD66</accession>
    <name>I4YD66_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_57357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958204.1">
        <property type="nucleotide sequence ID" value="XM_006958142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD66"/>
    <dbReference type="FunCoup" id="I4YD66">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD66"/>
    <dbReference type="GeneID" id="18472906"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57357"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_29_2_1"/>
    <dbReference type="InParanoid" id="I4YD66"/>
    <dbReference type="OMA" id="YVPSKKF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="165" mass="18984" checksum="81BF83D283BB4DC9" modified="2012-09-05" version="1">MSYSGDQTLNQQSAYVPTTASFKSKSTAQKMNKGDKRKTVLRKGAGQQWEDPTLLDWDPSHYRLFVGNISNDVTEQLLDETFSKFKSYTKSRVVRDKISNKAKYGFIAFADPEDFLKAWKEFDGKYVGNRPITLTKSQTKINHNEIGYRKSSQLNSAKKNRHQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDJ9</accession>
    <name>I4YDJ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957846.1">
        <property type="nucleotide sequence ID" value="XM_006957784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDJ9"/>
    <dbReference type="STRING" id="671144.I4YDJ9"/>
    <dbReference type="GeneID" id="18473769"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60144"/>
    <dbReference type="eggNOG" id="ENOG502QSII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567664_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDJ9"/>
    <dbReference type="OMA" id="FHPGAWE"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="481" mass="53206" checksum="DECDAA111949D5E2" modified="2012-09-05" version="1">MAQFVPSPASVNPEATGHAPDDADAQTRLPSICVDYLSHDWEEEDVWTSWRSMTRHKNDIANGVRLENASWRTWWKQRNKLKTISPETLNWLKDSDVTWLYGPLHTAVDPVPQPKASTLEDHIDLDQGHGTKPILKHRTISELLTMPNQSSPSIEAIPDDEQSDVPSDYQSDASVSSAASPIESKRPKFPNSHSEPLIKTALHNSDTINQHNNDLDTASPASKLMSPNATNSDGDASNTSSMGSKRHITFNSFVEQRISLDEPERIADEALASDEDEVSSEDEGLTFRSRSLSNNTSKSRTRSSSAASDLSSIPAPDHITIAEIEPTTLKINPHGLDEDDSSFDIIQPPNDSNPDYVPTARRSSFYNNSSDEDDDQEQSTAAFRSEAPPLASPAHGFLPQAWEDNDEFDYFSGKFDDFDDDEDNKVIEDISKQPVQAHHQPNVRKGVLKKSPSYDRNVATIGAVPSTAVGPEPSEERGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDV6</accession>
    <name>I4YDV6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957948.1">
        <property type="nucleotide sequence ID" value="XM_006957886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDV6"/>
    <dbReference type="STRING" id="671144.I4YDV6"/>
    <dbReference type="GeneID" id="18475438"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68608"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043841_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDV6"/>
    <dbReference type="OMA" id="CFWIVVM"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="33511" checksum="F25D5E49EB7D5E04" modified="2012-09-05" version="1">MPTIPTLVSTIVGLPLSLWTFKCMMLVAFQRRIIYMGYSPIGARQELLRDIDTLGPFDVRKISADVSPKVRLDGLEVCRKSAGDNNKPSILFYLQGNAGNPLSRLPVFHKLLHDKACVDDLKIIAFAPSSYWTSSRRRPTQTKLLEDYRCALQKTCERYPESPIFIYGHSLGGAISTILLAEHLHDENINGLILENAFGSIPDMIKAYFISPRIPYWHLHRLAFDKWDAKSVAHKVKAKTLILISENDELVPRAHGEALHSLISNSQLEVIQGALHENAYTSTTWSRTVSNFIKTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE62</accession>
    <name>I4YE62_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_63463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957518.1">
        <property type="nucleotide sequence ID" value="XM_006957456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE62"/>
    <dbReference type="STRING" id="671144.I4YE62"/>
    <dbReference type="GeneID" id="18474841"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63463"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650859_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE62"/>
    <dbReference type="OMA" id="DIMTEYT"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="422" mass="48452" checksum="1ED9B3B306075DB2" modified="2012-09-05" version="1">MYSNYDNTNNERHTLSGSDSDLVGNKRQLLDKNIIPSTVLGNIDPPINKFDIAIAWLTDSYIPCEEASVPRQRMFQSYHDYCESNSLESLSSRSFGKLVIKQFPGLKIKRIGKREISTYHWDPQQSNDIFINMDTSACQPPRLQETSTEYLLWLHASHCATVVHCLGRWQFDVVEDELREFWLMERAHLNCNSFHNTQHFNLFLLAEVQAYQDAVAALQMQLCDALSPDRVSMVVTFVERLERMHRNTNCYIDELRGCLGYFIHLMTRYAELAKITRLIDTNLSEVAIISAMYATWSTSLNFDSIVKRCITLYNCNDAVLFSALCGFAEVLKNLNTNPTRKLITFADILVDTIPLNSKYNLSRSSASLIQCYSTLHICSNVSSKILTDLMLKNDINLTNFFLLKAWFDDYVGLTTLRNMTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE88</accession>
    <name>I4YE88_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">sum3</name>
        <name evidence="20" type="ORF">WALSEDRAFT_59990</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957541.1">
        <property type="nucleotide sequence ID" value="XM_006957479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE88"/>
    <dbReference type="FunCoup" id="I4YE88">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE88"/>
    <dbReference type="GeneID" id="18473669"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59990"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="InParanoid" id="I4YE88"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="165"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="384"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="535"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM22280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="591" mass="65096" checksum="976DEBF7026D04D6" modified="2012-09-05" version="1">MESKMSNNSAGATQPARKYVPPHLRAQERSPSVPPAVGASSPMPGAFTRTPSNSSFAGRPSKPPSSLPPRTRRPDGYGKWLDGIHIPAPRNERLELDLFGEPGDPFKQSTGINFDKYADIPVEAKGHNVPEPIIEFTNPPIDPHLLENIKFARYTTPTPVQKYSVPIIGQGCDLMACAQTGSGKTGGFLFPILSECFKNGPVQTPPANPSKYSTKVYPTALILAPTRELVNQIHEEAKKFAYRSWVKPAVVYGGAPSGEQMRQLDRGCDLLSAAPGRLCDFIDRGKISLANVKYLVLDEADRMLDMGFEPQIRRIVQGCDMPSVEDRQTLLFSATFPREIQLLAGDFLKNEIFLSVGRVGSTSENITQTVEWAEDFEKKSVLLDILEGHMEPESNNRTLIFVETKRMADILCDFLLQNNLRATAIHGDRDQREREYALNTFKMGYNPLMVATAVAARGLDIPHVSLVVNYDLPSDIDDYVHRIGRTGRAGNTGHAISFFNQNNLNIVRGLVEILREAKQEIPIFLEQSLQQASVFGGRGRGRGGSRGRGMSSRGGGSGFGSPFRRTASSWDSPSNSTSFSHDSPAYWIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEI3</accession>
    <name>I4YEI3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_5936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957460.1">
        <property type="nucleotide sequence ID" value="XM_006957398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEI3"/>
    <dbReference type="STRING" id="671144.I4YEI3"/>
    <dbReference type="GeneID" id="18473310"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_5936"/>
    <dbReference type="HOGENOM" id="CLU_002678_42_25_1"/>
    <dbReference type="InParanoid" id="I4YEI3"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="63" mass="7484" checksum="B559465409097CA6" modified="2012-09-05" version="1" fragment="single">PQCNRAFARHFNMKQHMETHNPMRVKPFLCEHSSCGKRFSRKHDLLRHQTSIHQKHAKNCTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YER6</accession>
    <name>I4YER6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_68409</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957699.1">
        <property type="nucleotide sequence ID" value="XM_006957637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YER6"/>
    <dbReference type="FunCoup" id="I4YER6">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YER6"/>
    <dbReference type="GeneID" id="18475392"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68409"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026967_0_0_1"/>
    <dbReference type="InParanoid" id="I4YER6"/>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="170"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="415" mass="45609" checksum="9FEF54878FFC1578" modified="2012-09-05" version="1">MFKIIPGIQSYDWGKIGRQSKAATFAEVSIPGFKIEDKPYAELWMGTHDQAPAYLSSDPSTKLAEFLSRNPDQVGQKVKDAFKETTSDGGLPFLFKVLAIEKALSVQAHPNKKLAEQLHKARPDVYKDSNHKPEMAIALTEFNGFCGFRPKDQIVNFLENVKELRAFVENKHVNDLKQATTDEQTRGALKNVFRNIMSASENKIADLTKAIVDRYSNQSGEDVSDENVYLVRQLVLTLNEQFPGDIGIFCAFLLNVVHLKPGESVFLKADDPHAYISGDIMECMATSNNVVRAGLTPKLRDVDTLVNMLTYESATADAQLMDTKSLDGAAGTVVYDPPIDEFSVARVTLSNGKSTEHRALNGPSVIVVVSGSGSIETDSQTETLRKGEVLFVGADTPAVIKASPDIELYRAFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW4</accession>
    <name>I4YEW4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957179.1">
        <property type="nucleotide sequence ID" value="XM_006957117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW4"/>
    <dbReference type="FunCoup" id="I4YEW4">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEW4"/>
    <dbReference type="GeneID" id="18473558"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59798"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="InParanoid" id="I4YEW4"/>
    <dbReference type="OMA" id="MVVSMTE"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="556" mass="59784" checksum="FEFD0B4370553635" modified="2012-09-05" version="1">MQTLKAIITKLTTKDGWLDNNSFNYASLFKPQFPYSLPNKPRKRTKPSPFFSLDTELPILILLVTGLQHALACLAGVITPPMIISSSLNFSPDLQSYMVSSSLICSGILSIIQMLHLKIPYTNKFIGTGIVTIVGVSFNTIPVFSSMANRMYNNGTCPMDDQGNKLPCPEAYGYFIGTCMLASLLEIGISLLPSKVIKRICPRVVSSTVIIMIACNLIQSSGFVNWAGGSDCTTACPSADAPRPLPYGAIEFIGLGFLAVLTILLVEIFGSPFMKSGSLIIALAVGSTVAAACGYCINKTRESPVITFIWVHTFKLRLDPPSILPIMAIYLVNSIEALGDVTAASEASRLSITGDKFDERIQGGILADGLAGIFAGAMTQAPMSIFAQNNGIIALTRVANRSAGIVCACYLILFGILGKISGVFLSIPNPVLGGVTSFLFANVLVSGVRILGTLSWQRRDRIILSTAWMFAFGVLLVPDWAANFFRGVQTNGNEALEGWFETIETIVSTPSIIGCLMAILMNLIIPSDVVENANENDIEHGIISEVPSFKSTDMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF22</accession>
    <name>I4YF22_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957234.1">
        <property type="nucleotide sequence ID" value="XM_006957172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF22"/>
    <dbReference type="STRING" id="671144.I4YF22"/>
    <dbReference type="GeneID" id="18474819"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63204"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544235_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF22"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="501" mass="55722" checksum="B97309903DBA818B" modified="2012-09-05" version="1">MSSSIALSFKNQTVVVTGGNKGLGNAIAKDIAKAGGNVVILARSEASAEASALEKEFGVKAKSYRCDVGDEKRVDTVFSEIIKDFGEIRGVVANAGVSVPKPAFEQDASSFDYIMKTNVLGSFNIAKVAAKKWVETGYKNGSIVVISSMSSQIYNVQGPGEPLRQVFYNASKAAVSSVAKGLAAEWIEHGIRVNIVSPGFIRTAQTQGMDPKILEAQAQLVPMKRFSDAPEQSKPVLFLLSDLASYMTGSEVFVERKVYDMRRTQTLKDHYDYYDKWLGRMVRVDYISDTMTDTTLLALFRPAGPIAHIHIEKVYDKWDVFHYAVIVFHSKLHARLSTVLSGMFLAGSYIYVALVSSCCEIVPYSPRTLGDILLEHKERHLLRNSLSCVSIFDKQTVPTMVSKMEILTMPHPSFCVADTIESGAKLEDADERRYLASLEDDRVERGNMYEDWKELNSRIHKTHSSHKIQIQPLGSSQRDNLPSRNQQKHSESRKNNCVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF49</accession>
    <name>I4YF49_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_53899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957260.1">
        <property type="nucleotide sequence ID" value="XM_006957198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF49"/>
    <dbReference type="FunCoup" id="I4YF49">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF49"/>
    <dbReference type="GeneID" id="18472637"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53899"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="InParanoid" id="I4YF49"/>
    <dbReference type="OMA" id="LCEIICD"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="34865" checksum="826DBA962D7D1606" modified="2012-09-05" version="1">MLGGDLDSQIAQLKKCETISESQVKELCLKAREILVEEANVQYVDSPVTICGDIHGQFWDLMELFEIAGQCPSTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGNINVWRYCCEVFDYLSLAAIVDGRTFCVHGGLSPMIQTIDEIRSIDRKQEVPHDGAMCDLLWSDPDDIESWNISPRGAGFLFGAEVVRQFVHANDLDLIARAHQLVLEGYKVMFDNSIVTVWSAPNYCYRCGNVASVLNLNENGEQVYKTFEAAPQDTNTVPFKRPTPLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFD2</accession>
    <name>I4YFD2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_36704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957339.1">
        <property type="nucleotide sequence ID" value="XM_006957277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFD2"/>
    <dbReference type="FunCoup" id="I4YFD2">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFD2"/>
    <dbReference type="GeneID" id="18471974"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36704"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="I4YFD2"/>
    <dbReference type="OMA" id="QLWIVPP"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="403"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="841" mass="91734" checksum="38F091A16909BA33" modified="2012-09-05" version="1">MTLPELNVDELLEQLTVKEKIDLLAGRDVWHTVANKRLGIPSIRTSDGPNGVRGIYFFEGTPSSCFPGATALGASFDNELLERVGSALADECIAKGVHVLLAPTINIQRSPLGGRGFESYSEDPELSGTLAKYYVKGLQDKGIAATIKHFVANDQEFERMSMSSEVSERALREIYLRAFEIPLRESEYKPWAVMTAYNRMNGLHCSEDPRLLKDILRDEWKWSGAVMSDWCGTYSADASTSAGLDLEMPGPPVVRGAALQRALAAKKVTIESIDACARNILELINKVRKSGIDEDIPEQVLDTPDIRQILRESSANGVVLLKNDENIMPIRKGIKKIAVIGTNAESAIISGGGSAALRASYSISPLDAIREQAKEIGAEVVYSRGGNAHKLTPLFGPELKTKDGKAGVDVSFYASDPSAGNVKPAHVLHAHSSHMFFNDNLPSTEVFPLTCWSEATGTFTPNKTDNYELGVAGIGKIDLYINNEKVVDNSTDPQPGTLWFNSGSEERTTVKHLEEGKQYTITAKLYYSSEGSQAAGTLSPLLRGGIRFGIAPFKSQEAFIEEALEACQGASLVLGFVGLNNDFESEGFDRPDMKLPESANAFMDAIASANENTVAVVQTGTPVELPWVNKVKGVYQAFYGGNEVGTGLADVLFGKHNPSAKLPLTIPVELRDNPSHLNFGGENGRVSYAEGVFVGYRHFVTTGRQPLYPFGKGLSYTSFAITEPHLESKGDYEVVIKVNVKNTGDVAGKEVIQLYVHDVESRLARPYIELKAYGKTKTLNPGESQEVVLNLNRRAFSYFDDLKGKWVIEAGEFRLLVATSSATEDVKHTLSHTINQSTEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFK2</accession>
    <name>I4YFK2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957402.1">
        <property type="nucleotide sequence ID" value="XM_006957340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFK2"/>
    <dbReference type="GeneID" id="18475359"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68174"/>
    <dbReference type="HOGENOM" id="CLU_578971_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFK2"/>
    <dbReference type="OrthoDB" id="10488420at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="55158" checksum="B7FA2639BC5D9222" modified="2012-09-05" version="1">MNVGIMKLPDDILSRVMFYEPELSQTCRKLWALGRAYRDAIVGPHAPTKVKINEQKVYYQNLKRFLDNFKILAESSKVDYTKSIRIHFLGNRNNCPAKTSEYIQRTLKLLPLFWNLQELAIQFDYVNDITRLLTYMPRLRSLHLGVRIFTHMVEFVGMLTTHCPKLINIVISIRVFEGESNVWDDIRFKQLNDFLNGLSKNIGRVPILYRPYKDPLSILPNEIIELLFDHLCHDERGVLSAKELRLVNKAWFIAISTNYVYKNKFSLSDRDFLTANYTETQMEIIKRRLSRHIERCAYIRSIEIDVHQYNRNFLRDFFFNAIDKNQSKPFETVVVNYHGGPFNSEKKGFLMTITESVLNLNAKDLILNNYSKIVGKRETEISHLSLFEGNLILKNWRLKGDPECLVSSFAKSIDLHGFDVDGKSSQFSDRSEMSLSFLVNCPQLVHLKMDNSNFFMDSLVIKYFDENLHECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG16</accession>
    <name>I4YG16_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_36154</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956954.1">
        <property type="nucleotide sequence ID" value="XM_006956892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG16"/>
    <dbReference type="FunCoup" id="I4YG16">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG16"/>
    <dbReference type="GeneID" id="18471946"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36154"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG16"/>
    <dbReference type="OMA" id="QHLFRAN"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="196" mass="22079" checksum="B437399F23607D6B" modified="2012-09-05" version="1">MSNLPKLIAQVTFGASRAVGKAFVAMGRQAVANATYKPDLNEPIEQSNDKNAPQGNPSQKATKQLKMTLDEAHLILNVKREASLEEIKENYDHLFKVNSPPQPKVDPKAEAAPKKPQRKSHSNKLKTDTIPYSHYLQSKVVRAFERIQAEQSSRIEMEKHQDSIEAEQPEIEKKEGEVPKKEGDAPKKEEQTEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG30</accession>
    <name>I4YG30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_62940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956968.1">
        <property type="nucleotide sequence ID" value="XM_006956906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG30"/>
    <dbReference type="FunCoup" id="I4YG30">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG30"/>
    <dbReference type="GeneID" id="18474799"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62940"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1295302_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG30"/>
    <dbReference type="OMA" id="KYPRGML"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="58"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="213" mass="23664" checksum="3F391C88360CF089" modified="2012-09-05" version="1">MEIKHLYKNNSIDDEWLDSCIDYLRSDMGITNNQELLKQTQLQFINSDLADSTTGGLPSNILELHNKCIFPTPSKGILLQVQSITDVGISSLSLKNNKEQKHTIKLVLSDGRMSVNAFEYAPIPNLSISTTAIGSKVIVKNVQVLHGTLLLTPQSLAFKGGRVEELENNREKIIDNILDKRLGIKPETVQSPAKPRNAEVQRTSNDVIEIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG72</accession>
    <name>I4YG72_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 9">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_56628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 9"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957009.1">
        <property type="nucleotide sequence ID" value="XM_006956947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG72"/>
    <dbReference type="FunCoup" id="I4YG72">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG72"/>
    <dbReference type="GeneID" id="18472834"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56628"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_4_0_1"/>
    <dbReference type="InParanoid" id="I4YG72"/>
    <dbReference type="OMA" id="RPDHRMI"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="12">
        <location>
            <begin position="63"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="377" mass="43398" checksum="933F323DFD68C984" modified="2012-09-05" version="1">MLNDQSKFIKEHDLVVLWLTKEQQQLLKIESDKIFQNKFGRFNTNDIINKRFGDKLVSTNNKGFIHLLKPTPELWTNALPHRTQILYNTDISFILLNLNIKPSSVVIESGTGSGSFSHAIARTIGRRGKLHSFEYHKSRSEKVSTEFEEHGLSDIITVYNRDACKLGFTDQLNDSVDAVFLDLPMPWLAIPHGKKSLRKDKVGRICCFSPCIEQVLKTVKSLNDEHFANITTYEVLTRNYDTSYNQVPTVNDITTKLKHILEKKEFRRQQQISSAQAKHNKQLKINEKTEPSENDVKSEETETPQQAPKRKFEQLAPQDASTLLSRPFMDTRGHTSYLTCEYTSAIESLQTNDDQKLHHFCLMTLTMSPKRKLSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG80</accession>
    <name>I4YG80_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_62993</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957014.1">
        <property type="nucleotide sequence ID" value="XM_006956952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG80"/>
    <dbReference type="FunCoup" id="I4YG80">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG80"/>
    <dbReference type="GeneID" id="18474803"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62993"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="InParanoid" id="I4YG80"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="399" mass="47447" checksum="85576D67D1987F80" modified="2012-09-05" version="1">MTTEFAKSSNEALEIRLRRIELDENLLESEEELRLTRPWNPEFTYPIFGTEEQIYGYKNLRINLDMASGSLRSQLRVSYEGKKDDADNVEDKLEEFIPLEKGDFDSIVKDDAKEFRPPGELVTSYTRNSAKSEGKGKGKRRRVETSNGSITGEEGDVVYEIYRSSWQTAGWKDFNRRMQFFLLLFIEAANYLDEDDDNWEFFTLFERRCREDGSYAYHFVGYSSLYSFYHFPTGHRQRLSQFLILPPYQRQGHASELYNSIRSDVLSRQDVIELGVEDPSEAFDILRDINDLRWLNEMKLLENKTALDIDRQWIEQERKKLKVARRQFLRLIEMLLLHKLDPKNQEQLKRFRLLVKDRLYRFNYEQLIDLTPEERKAALQLTYEGVIDNYRDIILKSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGA4</accession>
    <name>I4YGA4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957035.1">
        <property type="nucleotide sequence ID" value="XM_006956973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGA4"/>
    <dbReference type="FunCoup" id="I4YGA4">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGA4"/>
    <dbReference type="GeneID" id="18473514"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59720"/>
    <dbReference type="eggNOG" id="KOG1813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050460_1_1_1"/>
    <dbReference type="InParanoid" id="I4YGA4"/>
    <dbReference type="OMA" id="RCGHYYC"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="325" mass="36158" checksum="3350369CFFA30926" modified="2012-09-05" version="1">MTDVVSFKKPSKKGRPAALRQKSPPKDNSRESHEKSSVATVKDRRSAVKGVGKKRQRETSKGEDSDNDQSGGGVVDVAWSATNSNDNTMNRNTAVVDLDAETIDGPNLKKYKEGDEVDAQDLEDDGMYKGLNSYTSHLKKKPDSSMSDKFKAGPVRAPTNIRQITITDFQPDVCKDYKETGWCGYGDTCKFLHDRSDYMAGWQLDQAWNKMQAQKSGAAAFEDDSDDSEDEDLPFACLITREPFVDPVVTKCGHYFEKKAALKRYQKTPKCYACGTPTGGIFNKPKHLIKKLQERAAKEEAEAQEADSDDNGIEGLEERNETSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGF6</accession>
    <name>I4YGF6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="13" type="ORF">WALSEDRAFT_53819</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957083.1">
        <property type="nucleotide sequence ID" value="XM_006957021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGF6"/>
    <dbReference type="FunCoup" id="I4YGF6">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGF6"/>
    <dbReference type="GeneID" id="18472633"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53819"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGF6"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="315" mass="34911" checksum="15E5BE38DF4898DA" modified="2012-09-05" version="1">MQSEQVFDSIKARLLNDDNLADQYRALFTLKAIGQKGDRRAIEAIYEAIQKSSSALLKHELAYVLGQINDSYALPHLNTILADESQDVMVRHEAAESLGAISNLDSLDILKKYSADQSLDVSIRETCDISIKKIEFDHRPGKDTDNDNEENQIPVIDPAPATKSSDSNAKDVKNLRDIYLNDGLPLFERYRAMFGLRNIVLNKALNAIADGFTDKSALFRHEVAYVFGQIDSPAAIPCLLKVLYDENEHEMVRHEAAETLGGLGADSKTAKDALIDFANNQSAPKVIRDSCIVALDMLAYEQSGQFQYADGIEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGL9</accession>
    <name>I4YGL9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957144.1">
        <property type="nucleotide sequence ID" value="XM_006957082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGL9"/>
    <dbReference type="GeneID" id="18473556"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59787"/>
    <dbReference type="HOGENOM" id="CLU_491089_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGL9"/>
    <dbReference type="OrthoDB" id="3360384at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="555" mass="60946" checksum="41BAA17D7A8B8DD5" modified="2012-09-05" version="1">MSNNVDRRKPPPLQLNNYTTQSAHTTRYPQLYSDDIKSPRESHSSVNLLDSDSASSIFDASSGAHASTPPSLTNTPPSISASLKPEKGDRAFNETKLADLISIGDEEENRGLQLEKDNRGNAPPPTPEPAHTSPPLSVPAKLSQVSPSVERLYYIPPPTPPKFRTSSTPVLHPMSPGNTHRTPRTLKNARNTELMNNDSRIEEVPEDEDEDEDDGPRSPTPASSRNASNEVDRRRPSLGANVKFKEEEAEPKSAFEDSSFEDRQDTTMSRQRMPSFWEKMRKSNILSPSASTNIGDDASSDSGSHISIHIYDSDLQDIDNIQASSSHSVARALATLPSDAIKNVKDVPDLGLERKPFLARIFDADDSSAASNCFFLGFIFGPAIWLIGGWTLDARDGTAVQRVKADDRRRDWASEWNEISLAFKIREREKGSKDKEKVLLSEKRTHSKNSSNGSSSFARSDSGAPMEAHPSQSSIAASWGNQGVTNRPPLNNYLFNHGVKPRKFVSSEPEMSILPPLTRDSPDRWVLRCRIAAIVTVPLAIGCLIAAIVGIAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGY8</accession>
    <name>I4YGY8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRT1</name>
        <name evidence="9" type="ORF">WALSEDRAFT_35654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956622.1">
        <property type="nucleotide sequence ID" value="XM_006956560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGY8"/>
    <dbReference type="FunCoup" id="I4YGY8">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGY8"/>
    <dbReference type="GeneID" id="18471919"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35654"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="InParanoid" id="I4YGY8"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000947">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="703" mass="81083" checksum="F302A8DA4EAF14E2" modified="2012-09-05" version="1">MSVEEIDFSDIYKKHQLEDLNHLDSIVVLDGMPEVGEDKMPKLFKALRKTFSGKAQIEVEDDQFYMPMTEGKGQGYIFLTLKNSQEATNLIARLDNAPFDSKHTFLINKFSEIDQYLNASDQFVQPTIQEYKPKDHLRSWLSDSQGRDQFITFQNDQVNLNYHNRSGAPQVVQTKNNWTNSYITFSPEGTYIATLHRQGVMLHGGPALNEVCRFAHPNVKLVDFSPKENYFVTWSNEPIVLPQPGSSTVCPFSEDDQGNSLAVWNIKTGDLLRTFPTTPGKMPWPHIKWSGDEKYIARLVPGQQISIYGVPDMGLVDKKSLKIPGVVDFDWCPWGDKDAIASANNKGTRENMLAYWTPEVENQPARVTLLSFPSRQVLRSKNLFNVSNAKLNWHNHGDFLCVQVHRHTKTKKSMFCNLEIFRVREKDYPVEVVELKDLVTFFAWEPKGERFAIITQPDTTANQQLAPGVTLKTAASFYQLDKAKGVFKLLKTLENKSVNTIHWSPRGRHLILATIGSQSKFDLEFWDADYAADEKKEEIQQIANAEFYGITDIEWDPSGRFIAASASVWRHQLENGYAVWDIKGQELTKASVENFKQFLWRPRPKTLLPKDEQKKIRKNLREYSRIFEDEDAAEESNVSAELLTQRKRLVDQWNEWRKRCRASLEQIQSEQKSSNQGKDDTTVEEWIDEVSEDCFYCYYYTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH28</accession>
    <name>I4YH28_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">SNF2-family ATP dependent chromatin remodeling factor snf21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_59530</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_006956598.1"/>
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        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH28"/>
    <dbReference type="GeneID" id="18473409"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59530"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="InParanoid" id="I4YH28"/>
    <dbReference type="OMA" id="VNYISHT"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
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    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="16">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="15">
        <location>
            <begin position="326"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="515"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="833"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM23270.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1443" mass="164875" checksum="6DC215A533B807FE" modified="2012-09-05" version="1">MDFNQFNRPPQQVPQTLPQSMNRERIQAMVQRLNILRSQGQNERTSTEFAQMAGFLRMFGQFQQMRQQQLQQQQQQQGAPQQAPQSLTPVQINALKAQMATYQFASQNMPTPEHIQREAFEPAQYPVAPPPEDTIRDKTIGAAVEINKVKEETPQKPHEYQSYISPLVYLEAGPNSSNNSTKNQRIIIPSVMPQGIDPYQLIEERNHFQNRRMYWRIQELEDMTSTTSDQPAHITGNDILDSKAPQDIDQKPESPSLTDVSSSDKMKALIELKALKLVEKQRALRQDVISAQSHATLLTTDRAAFRRFKKQSLRDARATEQFERKQRSERDRKSRQKHLDYILSIHNHANNLRQANRDAVAKAQKMGRAVLKLHGDVEKEEQKRVERVSKERLAALRNDDEEAYLKLIDTAKDTRITHLLSQTDAYLDSLTQNVLAQQNEVGMEDNFNFEVEEAPATEATFGGRRQDDEAEDQGKVSVDYYAVAHRVSEKVTTQPSILIGGQLKEYQLKGLQWMISLYNNRLNGILADEMGLGKTIQTISLVTFLIERKRQNGPYLIIVPLSTLTNWAMEFEKWAPSVSVAVYKGPPQQRKATQQRMRQGFQVLLTTFEYVIKDRPVLSKYNWVFMIMDEGHRLKNTESKLSQTLQQFYKTRYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGSNEKMDLNEEESLLVIKRLHKVLRPFLLRRLKKDVEKDLPDKVEKVVKCRMSPLQISLYNQMKKFGQMASISQSDKNGAVGGNNKSGIKGLQNTIMQLRKIVNHPFVFDAIESAVNPASISDDKLYRVAGKFELLDRILPKLKATGHRVLIFFQMTAIMTIMEDYLAWKGLKHLRLDGSTKTEERSSLLNKFNDLDSDYFVFLLSTRAGGLGLNLQSADTVIIFDSDWNPHADLQAQDRAHRIGQKKEVRILRLITERSVEEQILARAQYKLEIDGKVIQAGKFDNKSTAEEREDFLRSILEQEAEEEEEAGDMNDDEINELLARGEGEIDVFNQMDKERAQQDALFWQAKGLVGPNPGRLITDQELPEIYRSTYEWNPIIEADQEALEGGRRARAGVVYDDGLTEEQWVNALENDETTIEEQSRLKRERAAKGLTEEEEIDSPDVDGSKKRSGRPSKVGTPVPGGKRKRNPAVETPTIDYNDEPANKKKKPGLDPEAKERLKSVLTPFFDVVWTLTDEDGRLRADLFREVPSKKLYPDYALLIKQPMALNNIKRKIERKTYQNARECLSDFHLMFANARTYNEPGSWVVEDADAIQAGMDQAWNEKVLGTGVAGSELPAEATGPPQPDQILGPAALQAVAQPMVQHQVPQPPQPQNQMVNIPQMQQQPQIHQQMPQPAMQAAPMYQQPSYGAVDPNAFIADPMYYQQQAYDQQQQQQAAFEQQQQQQMYQSYGDPYGQQPHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH34</accession>
    <name>I4YH34_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956666.1">
        <property type="nucleotide sequence ID" value="XM_006956604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH34"/>
    <dbReference type="GeneID" id="18471298"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31415"/>
    <dbReference type="HOGENOM" id="CLU_1526358_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH34"/>
    <dbReference type="OMA" id="NEVIYEC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="20032" checksum="A4AF57E337E5D3ED" modified="2012-09-05" version="1">MKRLPIELITKITNYCNKSTLKSLRLVNKHLNDLTVDSVMECCKYDRSLIKSENRNLVKHLIVLDSLNLDSLVAILPSFNQLQSITLNPKSAQVVFEDPELDSTMALQKACPTLNQVTFDGDQVFKIVTQPAGIEFFKTKISACNDNSFCDSCDCSPNRFQPKLMLRKRRTLRVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH76</accession>
    <name>I4YH76_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy-related protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956704.1">
        <property type="nucleotide sequence ID" value="XM_006956642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH76"/>
    <dbReference type="FunCoup" id="I4YH76">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH76"/>
    <dbReference type="GeneID" id="18471303"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31441"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_5_2_1"/>
    <dbReference type="InParanoid" id="I4YH76"/>
    <dbReference type="OMA" id="ATWGGMF"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="414" mass="44824" checksum="3B01E7AADBB785F9" modified="2012-09-05" version="1">MPSKVNSELLFASMNQDYSCVSVGTTKGYAIANCEPFGRIHGKNDGATSLVEMLFCTSLIAIVGGLDRNSDRKLQIVNTKRQSIICDLFYPTKILGVKLNRKRLVVILEKEIYMYDISNMKLLWNSETSPNPDAVVALSSSSEPSYLVYPSQSPSTHTASSVAPPPLPNAQSHSNTGDVIIFDTLSQQAVNLLSAHKSPVAALALNSTSSMLATASDKGTVIRVFSLPSADKLYQFRRGSYPARVYSIAFNQVSTLLAVSSATDTIHIFKIGRSFDGTSSNNNEDITSETSDRLANQSGMLGGYEAFVDGKRRSSLGISISQKGLSFGKALTSGAGSISKHLPRGVTEMWEPSRDFAFAKLPERGIETRVGLSSTLPQLMVVSSQGLFYSYSIDLENGGECTLIKQYNLLDSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP4</accession>
    <name>I4YHP4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_62157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956164.1">
        <property type="nucleotide sequence ID" value="XM_006956102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP4"/>
    <dbReference type="FunCoup" id="I4YHP4">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP4"/>
    <dbReference type="GeneID" id="18474714"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62157"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="InParanoid" id="I4YHP4"/>
    <dbReference type="OMA" id="ANCMHAL"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="700" mass="77857" checksum="F250D52E5909AF58" modified="2012-09-05" version="1">MSSVQPDLNSEYRDKRKDAIKRVIANMTVGKDVSGLFPDVLKNMQTEDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDASDPNPLVRALSIRTMGCLRAEKIIDYLSDPLAAGLQDDNPYVRKTAALCVAKMYDLKPSLAIDRGFVETLQELVGDPNPTVVANAVTALTDIHNSPHPDSPGFIIDRDILNKILVALNECTEWGRISILSALCRYTPTEEKETEYICERVLPQFQHANGSVVLSAIKVVMINLQRLQREDFIRQLVRKMAPPLVTLVASEPEVQWVALRNINLILQARPDVLSSELRVFFCKYSDAQYNKVEKLDILVKLANENNVDTLLNELKEYASEVDVDFVRRSIRAIGRCAIKIEDAAERCVQVLVDLINTKVSYVVQEAVIVIKDIFRKYPHSYEAIIPTLCENLEEIDEPESKASLIWILGENAEKIVNVEELLETYLDSFIEDSYPVQLQTLSAIVKLFLKKPEGPSQSLVQRVLTTATSDCDNSDVRDRAFIYWRLLSTDTGAARSITIADRPPIVIPNLTVSRAILEELVQEISSLAAAYHKPASTFVGKGRLGIESIKKINPNEENENISKQKALNTVAQGVKAENLLDLDEDASPSTTQSPQESFNSFTANTATSNINHAPSPAQSNPVDDLLGLFGNATVSSPSQSVGANNDIFDMTTTNNTQGQNKNSGLEDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI97</accession>
    <name>I4YI97_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutaminase</fullName>
                <ecNumber evidence="9">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956355.1">
        <property type="nucleotide sequence ID" value="XM_006956293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI97"/>
    <dbReference type="FunCoup" id="I4YI97">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI97"/>
    <dbReference type="GeneID" id="18473297"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59342"/>
    <dbReference type="eggNOG" id="KOG0623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037550_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI97"/>
    <dbReference type="OMA" id="GNYGHFV"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="385"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="428"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="510"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="536"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="559"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="603" mass="66294" checksum="7CC5EC16AD28BEA1" modified="2012-09-05" version="1">MTSSRHTSMADRLFILDYGGGNTRSLTNSIKRLGYEFEWVKEPKDLANAQKLLFPGVGNFGQAVKSLNKSGLYEPLRQYILSGKPYFGICIGMQVLFELSAESPEDKGLSIIPGSVERFTTTPEDPKRVPHMGWSAAKRLPNSSQDPMNGLRDDCHYYFVHSYAVPYKAEQIAGWASTVTQYGRQSFVSSVQRGSILGTQFHPEKSGEAGLDVLNSFLKTKAEIRPLSNLTSYPEPVQVPLKEKDDLVKRIVACLDVRSNDNGDLVVTKGDQYDVRENDGNPESVDATASQREVRNLGKPVELARRYFSEGADEVVFLNITSFRNSPLEDQPMLELVKAAAETIFVPLTIGGGIRDMVDPDGTHHSASEVAHEYFRSGADKVSIGSDAVYAVEELLNRIKTNTQPILTGKSAIETISAGYGAQAVVVSIDPKRVYFNPETEKPAEEHLPSVIYGKDAKSNTTDEERKLAWWYQCTVQGGRGYRDVDVIQLAKGVESLGAGEILLNSIDRDGSKRGFDIDLINLVRESVSIPVVASSGAGVAEHFAEVFDATNVEAALGAGAFHRKELPIEDVKNDMRKKAINVRTELPKELVQNLSQGKVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIF9</accession>
    <name>I4YIF9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956415.1">
        <property type="nucleotide sequence ID" value="XM_006956353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIF9"/>
    <dbReference type="FunCoup" id="I4YIF9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="GeneID" id="18473325"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59386"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="I4YIF9"/>
    <dbReference type="OMA" id="FTQTIGW"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000004">
        <property type="entry name" value="EmrB/QacA family drug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="572" mass="61749" checksum="0814ABE43C5E5932" modified="2012-09-05" version="1">MSSTKDDEKQKKAVRGQWRENEKAHEIPDNNMWIVFPCIMGAVFLSAMDQTIVSTALATISDELHASEAEYSWVGVAYMLTSTAMIPVVSKLGNIVGEKIIFLVGIVVFLLGSGLCGGAKSMIWLCTARGVQGLGGGTIMASVQIIISLITPLQSRGKFSGLIGSVWGVASLIGPLVGGAFTEHVNWNWCFFINLPIGGVVLIALIVFLKLNPKERPPYKEVLKQFDYIGLLSILTAAICIIVGFSVASSSTWKNPAVIALIVVGGVVLLFAGVWETYTTKSQIIPPRLFKTLTTSSILFGTFFHAFGFFNGSYYLPLYFQVANESSPTLAGVELLPFSLGSSITSVLSGFLVARYKRYRPIIWCSWAVQIVGYALITTLERDSNRAKQVLYLLVTAFGVGGLFQTPLLALQAAVPLADMGLSTGAYVFVRSMAGTVAISVGGTIMSNLTKKKLANIPDAGAMASSSTEDLTGIKDIEPVELKLEIQQAYSEAIATIFIVVVALIGVGLITSLFIKRYSMEVKNVKQGETQEEDKEKQDDKEKQTDIEGSSQITAAAATESYEKQEKEKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIN9</accession>
    <name>I4YIN9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955678.1">
        <property type="nucleotide sequence ID" value="XM_006955616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIN9"/>
    <dbReference type="GeneID" id="18474668"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61668"/>
    <dbReference type="HOGENOM" id="CLU_1256918_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIN9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697732" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="220" mass="25491" checksum="92042236F2D4FEAE" modified="2012-09-05" version="1">MNYKTRLLILAICFIAFISALARRSDERQTGEQILFSGSKKELDAYLEDCKKNYLKITYQDQEKASDKEVVISITSSNVTSQKLDDSPTYKTWKENRKSTNVSEDETFLEFESKVLNCRLCLKASEQHNFTSDFKGLAVEMLKYLDNWTRRLLLPSKIRIVQAENAEQNVCAYREKCMDVINQVVSSFNETQIALLEHIKILERRNDLLEQFMSTTNTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ26</accession>
    <name>I4YJ26_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955804.1">
        <property type="nucleotide sequence ID" value="XM_006955742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ26"/>
    <dbReference type="FunCoup" id="I4YJ26">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ26"/>
    <dbReference type="GeneID" id="18474683"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61795"/>
    <dbReference type="eggNOG" id="KOG1309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039532_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJ26"/>
    <dbReference type="OMA" id="KVHMTAD"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="108"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="191" mass="21558" checksum="136BFCC58C603C8C" modified="2012-09-05" version="1">MTTSDFRYDFYQTPSIIEISLFVKNVREEDVDISFGEKELNVQFKDGRQFSLNPLSFDIKPTECKYTLKSMKVELILVKSQEGINWNSLVGDSSYKEAPASTSTASTSKPYPSNRGKDWNKVALDDEEETNDGNPDDFFKKLFANADDDVRKAMMKSYSESGGTSLSTNWEEVKKAKVETKPPSGTEAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ30</accession>
    <name>I4YJ30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_42080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955808.1">
        <property type="nucleotide sequence ID" value="XM_006955746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ30"/>
    <dbReference type="FunCoup" id="I4YJ30">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ30"/>
    <dbReference type="GeneID" id="18472240"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42080"/>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJ30"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="38440" checksum="59CB5DAF66915F79" modified="2012-09-05" version="1">MSRNFKVKVPATSANLACGFDCLGASWDDINLELTVSHVPYPARKHTSPIISYTGEGAGEVPLDPYKNLTTRVCIYVLRCHDILEFPDDLNLKVHNEIPFGRGLGSSGAAVVAGVLLADALADLKLSPSRQLDFALMVERHPDNVAAALIGGFVGSYLKTLPEGVLDPSSVPMSEVLPEYPPDASKDWGKKPPVPPKDIGHWLRYGWASQIKALVVIPQFELSTAKARGCLPEQYSRPDVVFNLQRLAVLTTALSITPPDPDLIWEAMQDKLHQPYRSELIPGLPEITKTLTPKSHPGLLGICLSGAGPTILALHTHNHEAIADGIFKIFAKNNVKCRMEVKSISESGSTVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJD5</accession>
    <name>I4YJD5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_42211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955904.1">
        <property type="nucleotide sequence ID" value="XM_006955842.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YJD5">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJD5"/>
    <dbReference type="GeneID" id="18472243"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42211"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000092_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJD5"/>
    <dbReference type="OMA" id="ITMIGEK"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF2">
        <property type="entry name" value="FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1401"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2431"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2957"/>
            <end position="3030"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3489"/>
            <end position="3563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="4011" mass="441513" checksum="479230F9152D31BA" modified="2012-09-05" version="1">METFMSFSSGSTICAAPRAEFLTNPELVISNLRCTHMMATPSIAGLFNPDKLPKGFELWTMGEKLSDRVISNFTRPGNELYNAYGPTEAAINVTLRRHPSTESGARLGPPIKTASLLIFHPTLNKIMPMGFTGELVIGGPQLAKGYLNMPEQTDKVFIDVEGLGRLYRTGDKARVVLDENNEWNNIEYLGRIGLEQVKLNGKRVELGEIDTVLSNTEGVRSVHTVVNQPEGQLCAFVTPNSTDLIDKCTDSAEKQLPSHMRPVVYFTAEDVPRSTAGKADRKAISRYVKDHISEGHFVGAAEEEQSGEIIEILDTPTLDKVVDCVSKTVDLNKEEIDVNLTLLALGIDSLRGVRFLSLAREAGLTGITIEDVIKGFSPAVLSNIAFKRMEDGFADDDSKKVAYTNIESEFRGQAIPAVVEALGFEPEIIRPATTMQTGLLALYSKTGTGYINHSVYTLKEDIDDNKLEKAWYELVKRHEILRTRFVLVDNSPISAFAQVVVDIDPSSTFEKVEGNDTNALVQSHIENASSKFSLLERTQTAALYSDSKSKKLVVSLHHALFDGASLALMLDELAALYNNPQADIHREKFVNALTDVFTADAKANNDYWSGKLQNFTPDPFPDLTGLRQDAKKDGHHVTNVTSKLSYTSFLEKARSLRMSPLSVVQAAWSSILLAYSESDANDVVFGSIVGGRTTDVLEHTVGPVFTAAPIRVTNPDDESLSAVLQSLVNSNADGMVHRHLPPKVLSGDNGIIYDTTIALQQFAQGASQTDLWSHSEYPPMVTEFAVVLEIWPDPNDTIRLRATCSNNVLIEESSKMMLTQFDDILSSILNGDLKRKFKDVAVDVNQSLKSAVNENPVRVEGVEKELIHSQFERNAQENPESLALWFKPNPADSTQDIKWTYKELDARANKIANYLTSTYGDLTDVPIPIHIEKTPEMFMAILGIVKAGGAWCPIDTTAPALRKKDLFERAGGPVVLVRDDENKALVSDIIEGKIDVRSFTEDVFNNQPSTKPEINTQSKHLAYLIWTSGTTGAPKGVPIEHSAAVQSLTVLQEEIPWKKNTHIRCLNFSAYTFDVSVLDVFYAWGKTRGTLCSSTRDNLVGSFEELVRGFEATHAFLTPAFMAQSSLQNCDSLESLISIGEKLPQPVADAWCKEGTVSLNTYGPAESTIIATYRRFTPNEITKAHNVGLPLSTISCYVVSDDRVLLRGAVGELALGGFQNARGYHRNPEQTNKKFINHPQAGNVYLTGDVVRLLHDGSCEFVGRNDDLVKLGGIRVELSEISAALGNCHEIARETTTFQLTRHDRPQKVVCTFVAAPALKGDEEDGLRTDDAALEVAAACKERAESSLPAYMIPNVILVLTHLPHTPSNKIDRKMLAKYYEDVDIANWESRLSGIDDGDDGSWNEMEQTIREVVAKLTNVTVESISKSSHLPALGVDSIRSLQLASKLRNAGVNAAVSQIAAFPTIKQLAKAIARATSNQTTTDTPKWLQDFNDAVIEKVRDDVKDVEFVLPCTPTQEGMLSETIKDPATYWSHHVFKLADNVDISALFNAWNAVANRTQALRTSFVPAATYGLKESVFLQCIQASPKLLVEEVQYNEDKILEERVRNIVNSWSSSNRPPVALTLATKSDGSRYLMTSLHHAIYDGDSLSFIYQDVEAAYKQVDVVKRTSLKSAMAFMNADSNKTKEFWTKVLEPFAESSNAEWPVLHNDKAQHSLRFWTKGFSDVKRPQINQLLQAAWAVLQSRYTSTTDVIFGETLSLRGLAEGLDSAVAPLIATLPVAVRVDENATAKQLIERLSQLAAESAPHRFVGLQHVRQALKYASGAPLFPALFVLIVESGETIEEDLFKDRFEIGELDVEHPIAINAFVRGDSVQVDILGSNSMMSESQVQLIANQMQALVNSMSDNADLPVSQLLSKIDDKLLAKSYDSDVTKSNNPLVALSQNALERPDDIAVRSDEGTLSFKQLEEQSNKIANSLSSKKVVGLCIPPSLESIAHRIGLFKSGKTYLAIGENLPANRKRLIARSLNADIVYTTKKFAEDFKLLGSDKVVIVDSEGYISELTKASSERPTLQETESAAITFANGQLDTHDYTVWSSTQLFENISVFAEHLKTSSSTSTFLNWLPGTFGLHILETFAPLVLGSTILCKRVESLQDNPRNVLKVSQVTHAILTAAWFEKECIVRSELPQLEHIVLAGHISSKALHESWKEANVWKTFAIAKSSLASFLTRYDIDQPHQIGKPLVSACIANTDANFGLRGEAGELCAFDSAGKLIHSGTVARMLDNDNVLFEHKASDVVDYRGSTINLEQVSRNVEGVSLQNVVCQSLVIQHPESMQPDIITFVARAYTSDPLDGTPAEINAQDESFARALVQSSTEKLQYGARPDIVLPMTFLPISDVIGGRTNHKVLRRLFSQVPLRNMVQKTSQDVTTTQRPLSEEEKTIAVALSEQTGVSVDTITPSTTTLELGVDSLSAISLSFHLKSEGVSVPPHIVLSGPSVEKLARLAGSPSESGKDTSAVRKLDKEFENNVREVFGDSVDAIRPCLPLQEGLVARTLNSTEPVYVNHFTFKLSSEVNVDQFVAATSDTIAANDIFRTCFYFGQSAVAQVALKEVDIIQRSQNVSEEASLAALQTKKVELERNIVDNIQSVAPVRVTVEEAQNKTTFVQFTMHHAVYDGETLPMFLEEIKQRYENRFSLERPSVDRLLDYISSQSLEIARTFFVEYLADLPQSGEIHIGNTSVDEISKTATLPLSKLELLARSMNVSLRVLVQTAYGVSLGETNGVSDITTGVVLSGRTVPVTGVESMLAPCITTLPVRVKVSDKTRFADLAQQAQGDSAQVLEYQYTPLRHIQKWLNRPSALFNSLFAYNKSSASGEQLWEQLEESSRVDYPLALEATADTDKDELVLRVVYSSSFGHARDVYHLLGRIDELLQDAQQVVEPLIPIDLTVDDGEKYDNEWSDAETLMRKSIAELCKLDEKTITKDSTFISLGIDSISSVRFAQALRKQGVDVPTSAIMRAGCIGALSAFVGGDQSDVTGEFDRIANALFNKYGREDIQVVLPATALQSGMLTQTIASQGKYYNIHHTLRLDDGVNLARLHQVVEATAQEVDILRTTFQTDDEYAWVMLVHKSVKVPWSEHTVDSAEDAAKLVAEVNVPRGEADFECPPYAFMVINTSEGTYVNMTMHHALYDGVSLPLLLGDIEKRYRGEIPARRPQFVQAAPYILDGARDTQGYWQKQMEGYVPKSLPRIDGVKASAHFANTTVGVTAKMTRIVRAAGVSLQSLVLLAWGKTLSTLLGSLDIAFGQVVAGRSIPIEDALLASGPLFNTIPYRFRLKKDMTNAQALHAQYAQYNDMEAHSHVPLRDIQRNARQRTLFESLFVFQKPFNGAQEDTFWKPAELTRDETQSVEYPLNAEFVDGGDSLSIHASCAASVMTGEELDGLLTKFVEVLADVVDHPQESCVGFPSTLGGLGDEKVDAQISYVEHNFEGPITKTMETVRAVFADIAKLPVEEISYGTPLYALGLDSVGAIQLASRCRKMGVKDLGVSDIFVGESIAGLDEVLSSRVKEVKEDSKPLVSATEAVNAMSNLHLRKDDVQAVLPLLPGQHYHLQAWLLNGHTFYEPVFAYEAPVRVNNIKMADAWRRLVKQHDVLRTAFTVVNGRPLQVLLKEHDAAFETHYCEDAESFIKDTIRKEFNRPSTLATPPVKLHLVQSDEKSYVLLRVHHALYDAWSIPILAADLWSCYKGRKSDSVGGFKNIVESLAKNGCNDEFWKEDLKDSQPALLPRVRESTEQVFFHDPAVVESASEATSGLQSHQVSLQAVCTTAVGRVVSEMSGVAHPIVGVYHTGRAATVEGIDRVSGPCLNLLPLSVAPGDTIAAAREVQRDIARRTIVEQDHLGAIAKVVFNDGVPLFNVYVNILWHAEKIFSLNDSSLMQMDVGAPTDFVSKDRIDVRSSVRELSTAGVSQDAVFLDIALDAQKDTVGVAARASESVMSSAELQAFIGKITTEIKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJG4</accession>
    <name>I4YJG4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955932.1">
        <property type="nucleotide sequence ID" value="XM_006955870.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJG4"/>
    <dbReference type="GeneID" id="18473171"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59094"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000772_3_0_1"/>
    <dbReference type="InParanoid" id="I4YJG4"/>
    <dbReference type="OMA" id="PYTRTWD"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="417"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1398"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="1833"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="1904"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1992" mass="226913" checksum="4F406BD013786CD8" modified="2012-09-05" version="1">MTDIEDYSSDDSLDSDIDLTEDEMKFSRDDDSRVKATRQFKHLPYQTESLDEMDDRLDFIIKKLINAAKAKDFDIGFNIWDHSLQCWLSLKYPMLRERRVQLTRLYYQLLVSPGMDGRFINLFATRLMSLISSKKRLSIKDIVLPWKPLYEILAKELFPKQRETSRKNVTNNLLTLVEYAQRFFHPSEYQNMLDTILPKMDGSSVDSIIATQAFLVHFLPLSHPQYWLPVTFRIWETFNSSHIDDQHLDLLARLTEKHLDPSISDPRIIDSLAPAPSEVPTVNRPPKDKNADSSWRGIRKDVGLLTESQFDTVMQKALSSFNISVGKLRGGDTLGPDGKISQNVVNLKKPTNRTFSLAIILVYSMSQEAGVAVSSAAGTPVSETPVNKGKNQLSAPTVGNFNSVNKYLGGSKALDALNKLILSTETYFHPSNWGAHTFALTYFISDVSSLFLERWTDEQKPDCKTPLQWRLTKQMKKEFVFSLRTVALLAMFSKDPISITNTQGCLRNLALLEPDLIYPALMERAYPSLEALTETHRTTAVITALSTIAPHLISRSKYYAGAKDLLPLLEFSLPGIDMNDPTKTVATCMFIIMSLHSVRIGDATTEGSDDVNIYRRKSVNPMDLDGCAPIEVENDSNNFLPEGREANDPPLSHEEVDNLIRTSTSSFGDWVIEFFRRVFILFENLPEEGGKHNRVGGRTEESVLHTIMVACEVVCGGLSPYIFQLALKQVFQYASTTTRANGVRVIGQLVSCFAKADPDKTLKQFFSWTTSTIRVEIKHGASSIGTTSTSTPFAGDTALHWALAILTGCVSHSGKALLDYKDELIDILKLTVNSCKSERGYMWSSSILQRVLQTLTQYYTVYTRFVNDAEWKNPSFARNHIYHWGKLFESDEVELDWHVPSSDEFDMAVELFKEVLEPELNRMEALITSTKGKDWSNDFCRISLHIRHSLTAIASLLQISAPEAGDPISDHGVFPKEFIQRQPEFKCQGVLKDDDRRLLYFNQFRYKFGETLHKIASVFNNPSEQDESSDSIDCVKAFLRSVRVYMSENGMDSSHYENTRQRYTFQKSVNKILPRQKQWPRLVFARRAAYLHATRLHLNTFNRERSKLDDQLLDDVLELSLSSYTAVRKTAQNTLQQLAAFYDGTKALSMDKIISSLKPGTDADRMKGALYILMNKSWISYYIVQFGQFKKVILALLGAQTEEKPSIQNLIQNLSREIIVRMPEIAALSSRLDCDNVKDVMNDVENSIGGNSVDSQEVIQAVGNVAVERIESREVLYDELITPLLDVAESNNTHWRYQLIAQRVLKNLIRRDKPTPERLTSYFLAQTISDHPKIREHAYGSMIKILHFIKLRTFGQGDNLREQLLLRSTKNPLKKTISIEEQKDFTTEKYLQAFKQPIVEWNEDVQLQDKTQSGWLCWGRTLDVYGLPPTDHFPFEWEVDSSASIKAITDTVMSSEWWYKFVSQLSIESSSNGPSYDHVNFIKSIFAMSEKPLGLLKSVIEPLLEDVSDRHKQRAASELLSGLLRGIKHWPKYALDDLWNWLTPKFPQFLGNVRPDSAATWDMFVVNTLYHRDPRRVYPLINWIVEQGDLMKNASSSAWSQAYSINLLRVTVKVISWRFSAWSDDISDMYWSIDALNHDYAEVRANIAKTLQKLSRSQLHPSFKNVAEFKKLSEIVPSDRVIIKHNAEDKILRHIQKVKQHLAKEHSNRLPPPMSALSTYDKVGLTTLRFLWDALHDSTRCSFYPFSIGLLGDFFNMRELSDSPDLQATAQSVLSLFAVIPPPREYSEPVIRTLLDVVSSSTKYRVRLHALPITAVFYFFQLPHISPATILGVMEELYKLLRDQNIEVREAAAETLSGLVRCSQRSFTLDLKKRFTETVSANSVLPRRRLENGDVNPNYAPAVLKLHSGILGICALINAFPYDVPSWMPELLAGVLAEHVSNSDTVISSTIRKTAQDWRRTHQDSWSENIHKFNEEQLSELSSLFLGECYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJH4</accession>
    <name>I4YJH4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955942.1">
        <property type="nucleotide sequence ID" value="XM_006955880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJH4"/>
    <dbReference type="FunCoup" id="I4YJH4">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJH4"/>
    <dbReference type="GeneID" id="18471879"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34689"/>
    <dbReference type="eggNOG" id="KOG1672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072378_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJH4"/>
    <dbReference type="OMA" id="KEFMNIT"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="17653" checksum="8D4E92B5E2CC896A" modified="2012-09-05" version="1">MQNEIKRRQIEAEFVSNGGYREYTSEREVMDVGLKEAKAVVHFFHPRFKRCEIMDNHLELIAYQHPSTKFIKVNVENVPFLVEKLKIKVLPCVIIFKQGVAKERLIGFEELGNEDNFNNKILEWKLFQMGAISSANDNNDRQEEGESDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM5</accession>
    <name>I4YJM5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="5">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="5">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="5"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955988.1">
        <property type="nucleotide sequence ID" value="XM_006955926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM5"/>
    <dbReference type="FunCoup" id="I4YJM5">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJM5"/>
    <dbReference type="GeneID" id="18473186"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59125"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJM5"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000006">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5 6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="34026" checksum="862453304CF8119B" modified="2012-09-05" version="1">MMFKNLINSVGRRSLSTSARRTNNLYDQSIPNLAVNKNTRVICQGFTGKTATFHCREALAYGTNMVGGVSPSKAGTEHLGLPVFGSVKEAAREANPDATVLYVPPPFAADAIIEAIENEIGLIVAITEGIPQADEIKVAHVLRQQSKSRLLGPNCPGVINPDGCKIGIMPGYIHTPGKVGIVSRSGTLTYEAVQQTTEVGLGQSICLGIGGDPFPGTTHVDALKLLLHDPKTESIVLIGEIGGSSEEEAAEYIKKNNVHNKPIVGFIAGVSAPPGRRMGHAGAVISGGGVGKAETKINALRDAGAVVVESPGEIGAAILKASKDAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJU3</accession>
    <name>I4YJU3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_26918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956053.1">
        <property type="nucleotide sequence ID" value="XM_006955991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJU3"/>
    <dbReference type="FunCoup" id="I4YJU3">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJU3"/>
    <dbReference type="GeneID" id="18470965"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26918"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="I4YJU3"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="419"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM24235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="532" mass="59222" checksum="FB33D71F2C101C84" modified="2012-09-05" version="1">MSQEDQEFNQQVKELQQFFTLPRFNKTVRPYTAAQVVSKRGTIDQQYPSDLLAKKLWKILEHKASTGGTSHTYGALDPVQVTQMAKYLETVYVSGWQSSSTASSTNEPGPDLADYPYDTVPRKVEHLFQAQLFHDRKQRHQRLSLPANQRGPAVDYLRPIVADADTGHGGLSATMKLAKLFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEQINRLIAIRFQFDIMGVTNLIVSRTDSEAATLITTNVDERDHAFILGATNPSVGSLVDVMRQAELAGATGPALEKIESDWIAQAGLKKYSETLADALRQNHVNENSIKNFLKEAHFSSRHKTLELAHKTGLPTTVNVFWDWDAPRVREGYYRYQGGTQCAVNRAIAFAPYCDLIWMETKDPKLAQAKEFASGVRAAHPNQWLAYNLSPSFNWDAAGLSPKDMQAFVWELGKLGFVWQFITLAGLHSNAYISDNFAKHFAKEGMKAYVEQIQRKEREISCDVLTHQKWSGAEYIDDLLSTIQGGVSSTASMGKGNTEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y506</accession>
    <name>I4Y506_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668272">
        <property type="protein sequence ID" value="EIM19048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960908.1">
        <property type="nucleotide sequence ID" value="XM_006960846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y506"/>
    <dbReference type="GeneID" id="18473091"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58958"/>
    <dbReference type="HOGENOM" id="CLU_1826803_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y506"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="141" mass="16150" checksum="DED0752D748A2514" modified="2012-09-05" version="1" fragment="single">MEHLTPPVMHRFIPELNSYQVQSTTHLNGSGSKRQQSNNDRWVFSYAVNRQYFGENTRHYPNIPNWVVEQMANDLLGRLYELDADNICINFNGEFGLWGKLQVANADTAGGIGASQCDPYYNNDYAGGGHWTYNYQVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y511</accession>
    <name>I4Y511_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668266">
        <property type="protein sequence ID" value="EIM19053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960902.1">
        <property type="nucleotide sequence ID" value="XM_006960840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y511"/>
    <dbReference type="GeneID" id="18475137"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66717"/>
    <dbReference type="HOGENOM" id="CLU_1856852_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y511"/>
    <dbReference type="OrthoDB" id="2564822at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="15980" checksum="D68AB8EE02A5A467" modified="2012-09-05" version="1">MVPYPFRYQVAHEEMELSRYKSPSDPYIPQQSRTEYAQRYIYDAAYIDSNLPIIRLLRCLPKHIDIDSYYMTVYPGELLALFNGSATVGLVSHKPSIRDVEEYEGWVYVGHSVAMLLIAPRYKDGLFHALSLKEVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y518</accession>
    <name>I4Y518_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_4042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960893.1">
        <property type="nucleotide sequence ID" value="XM_006960831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y518"/>
    <dbReference type="STRING" id="671144.I4Y518"/>
    <dbReference type="GeneID" id="18472172"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4042"/>
    <dbReference type="eggNOG" id="ENOG502S6X3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170506_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y518"/>
    <dbReference type="OMA" id="CPRSIKQ"/>
    <dbReference type="OrthoDB" id="4381806at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="61" mass="7045" checksum="CBAA1052DEA8BB6C" modified="2012-09-05" version="1" fragment="single">FIRQVSCYTLLSGFRLPWPPSCCLDELTPFVVSDERIFRHLNPTIGSSRIASSAYQKWPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C7</accession>
    <name>I4Y5C7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960791.1">
        <property type="nucleotide sequence ID" value="XM_006960729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5C7"/>
    <dbReference type="STRING" id="671144.I4Y5C7"/>
    <dbReference type="GeneID" id="18474636"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61608"/>
    <dbReference type="eggNOG" id="ENOG502RXUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341073_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5C7"/>
    <dbReference type="OMA" id="MSTMKVE"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697522" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="98"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="832" mass="91515" checksum="F86E3E16EF8E35CB" modified="2012-09-05" version="1">MHKVLGFLSVLILLLACAYGQDDNSSSTSLVENTSTTYTATATSITITSESSSIPTQTYVPIGNGNNDTNDENFDDEEDKKDELPLTIKITPALGVLGAVLIITAVPLAILGSTSRWTGVCIPVAYGSMIALMCILLSTVVLPKLHSINPSRASKALEGEILVGCAILGIIAAVVSWWFQRYVAYAVCGFAGMTLAWWIQCLHDGGVIHSMAGKWIFYIGLGTVCVVASFHPKVMPHLLRVSTSLIGSSAFIIGIDCFVKSGLKEFYVYNLGYDTLYPPISKNMDFLLTQTEIILLAVIAATTLLSLALQYRLAILAGRKAKMGRDEEAARDMGLDPDDTDVDSLEMKRNKRRDDARFAWENQNGTPRGAIAAAKYAVSNALFNKSSTPINVNLHEDERHSGSMEKNSYGDSNNVSPQLGQEFPQMPAPEIIDRPPSPNRSPPPLLPPLSSFSGPSAAAPEDVETNDPPPALPAPMKPEVQEGPLPALDLGFGSEMRTELGLPEPDPEELKAEAQMAKVKTLEPAIPPRPDGKRQRAPSAPTLLNRQSFDKAQEDLKQKEALLSDIANIRKSIDELRSRSTDELRNTADEDGKAASRSMADFPIRKNSKRMRAQSTQSFAKAVNKPNDEEARLSEWEQYVRSRQLYAPPSGVSRQINQDDNIEVSPAVAAAMDRRRRAPDFNSLVGGKYMPTMVQSEKQVSHEDYQSISPKQVDDGTHSRSRKSSVTYENIGRATPTLANRPAPRKSYSNDTVTGNMAYARTSTPNTLSKFDSSDYGGYNNRNRSRSMTVEELQARHRAHLSRLQSPINQKFEHDRRMSEFQAYQAYKQRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5U8</accession>
    <name>I4Y5U8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960616.1">
        <property type="nucleotide sequence ID" value="XM_006960554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5U8"/>
    <dbReference type="FunCoup" id="I4Y5U8">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5U8"/>
    <dbReference type="GeneID" id="18474578"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61517"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041558_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5U8"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="357" mass="39382" checksum="3D0197B92E33102F" modified="2012-09-05" version="1">MSEISLLPPADFHCHLRQSEMSDLVTPLVSEGGVETCLVMPNTQPPITTTDMAVEYRNKLQSLAKNVQFVMTLYLSPSLTPEEIRKAAANGITGVKSYPRGVTTNSDGGIESYEVYYPVFEAMEQENMVLNLHGEVPSSEETGVTVLNAEERFLPQLDKLARSFPKLRIVVEHATTKAAVEKVKSLPDNVGCSITPHHLQLIVDDWAGQGFNFCKPVAKYWEDRNALRDVIREGHPRFFLGSDSAPHPRANKLNKAPRFIAETQESVPACACAAGLFTSAILIPLCAHLLESFGALDNLEGFVSKNGRAFYQIQPKADSKPVKLVKEDNVVPIEYTKGDNIVVPFMAGNKISWKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y616</accession>
    <name>I4Y616_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCD1 alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_30417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960558.1">
        <property type="nucleotide sequence ID" value="XM_006960496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y616"/>
    <dbReference type="GeneID" id="18471148"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30417"/>
    <dbReference type="HOGENOM" id="CLU_1273134_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y616"/>
    <dbReference type="OMA" id="RDRTHWD"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="2">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="24800" checksum="E7FA1EF883A6DED0" modified="2012-09-05" version="1">MKDYKHMHLVNDFTLLEEKKRLVEELGKGASKSIHPNQQQRQHYKTNELIRTYANEGVELLLSPQGMERRRKDHTFFDTRAGELKMTCDIVEGDNIRVVHQVLQSMTIQSILKQKLNMDDISCLHTYIKSQDGRNIKAEHSEEIIETLRGTTVIDYPVLVLSSTPLDKRWRTEEHMKFDNDSDDSDSSISSSSSDSDSSDSDLSGIADDADITIDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y619</accession>
    <name>I4Y619_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960561.1">
        <property type="nucleotide sequence ID" value="XM_006960499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y619"/>
    <dbReference type="STRING" id="671144.I4Y619"/>
    <dbReference type="GeneID" id="18475769"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70637"/>
    <dbReference type="HOGENOM" id="CLU_673011_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y619"/>
    <dbReference type="OMA" id="GIRHESC"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46629" checksum="FCC611F13C4D7C8B" modified="2012-09-05" version="1">MPSQKATLTIDLPNTHNVITFKPPSTPQFSRTTPNYRTQDPTELRGSLELYLPSKRQVKSIKVNLKNVEDIIINGKSNRRLVLNEELLISVNELMHQGVHQYEFSFIVDTRTPTYERHSRGGTLQYLEAFVEFDEIFSKSLIHKMPLIFVGHPNSEGSFIPLEHLHQDYVEDIGPFEVSFKTQHLTIAGYILIGIYLPSPAPGLEIRGVKVSLEQHTTIHDEEKVIEKLPVNVNVLLDKGGKTDCLIRVPDQDSVIEGRYFVRLPKDDDCRPSTLDWSLARFRQAHFLVVDMLYKKEKLKMATVKIPLVLPQCLLSADSIALPTYTDTGYPVPAKRLWEMPLPQSHINCSCGKDDKSLKADAEGANNLDTYVPSREGIWISNLRTKEESIPSRDSYEEIRAAKRVNEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y677</accession>
    <name>I4Y677_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_41285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960501.1">
        <property type="nucleotide sequence ID" value="XM_006960439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y677"/>
    <dbReference type="FunCoup" id="I4Y677">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y677"/>
    <dbReference type="GeneID" id="18472209"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41285"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026936_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y677"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="34"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="444" mass="49803" checksum="E8AB2CD43FC011AA" modified="2012-09-05" version="1">MARRSREKKNRTHKKGGLLSHAPGAEETAGVKIPKSFVIKSGDVGKSVNQLVKEIRGILEPNTATRLKERKKNKLPDFLALTGTLGLTHIVIFTRSANHVNMRLARTPKGPTLHFRVERYSLMADLRNASKKIGNLANTHKVPPLLVLNGFPQDSRPHKLAAQLFQSLFPPLDVSNLPLSQARRLLLLSYNPTTKTIDMRHYEITVKPHGVSKRVRRVVPGASTANKLPNLSNVQDISQYILGQENSGYESAVTSDSEVESEVDEAGQPVRVVQLAEDFVGRGNKKDEKRAIKLKEIGPRLEISLVKVTTGLAGSQPKKHGMGGNNEGEVLFHDHVNKSKKEVKDLAKKHAERKAEIARRRKEQEENVERKRKDKEARKAKGETVEDDEEIDEEEVNDDFDDIGDPEEDLENLDFDEPSDEESERESDSESEDEEISNKKLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D9</accession>
    <name>I4Y6D9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_30330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960454.1">
        <property type="nucleotide sequence ID" value="XM_006960392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D9"/>
    <dbReference type="FunCoup" id="I4Y6D9">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6D9"/>
    <dbReference type="GeneID" id="18471144"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30330"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D9"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="618"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="767" mass="88860" checksum="DA24BEC88EB42C95" modified="2012-09-05" version="1">MSRNLKRTARDDLENKPKKAKQNIGSDSDSELSDLDNNYLDRNQDDGDSNNKEKPTNGDLPALKQEPSIKSEEPSPVKQPKKAPSKTPKKSQTPKTPMSQTPASPSKLKSENDATDTPKQEPDEEDDYKWWVQQDTLGDGTQRWTTLEHNGVFFPPEYVPLPKEVRMKYDGKNVELSLEAEEVAGFYAAVLGSDHAADQVFNKNFFNDFLDILRKHPPLDGTKIQEFEKCDFQPIKDYLDQEKEKKKAMTRDEKKAAKEQREEIEKPFTHCLLDGRKEKVGNFRIEPPSLFRGRGAHPRKGKLKLRIKPEQITINIGEGAKVPEAPSGRKWGSVQHDNTVTWLAMWKENINGNYKYVYLAPGSTLKGQSDMSKFEKARELKQHIGRIREDYEADLNNKVMYDRQRATAVYLVDRLALRAGNEKGEDEADTVGCCSLRCEHVMLRPPNLVTFDFLGKDSVRFYQEDIEVSPQVFKNLRIFKKEPKGPQDPIFDRIQTTVLNKYFGKFMKGLSAKVFRTYNASITFQEELQNTPKEGTVAEKLLAFNRANRNVAILCNHQKNVSKTHGAAMDKMGDRLKAIKYQRRKIRQMLEQVVEDKKVWKENPKFKEEESDLDDEWMDAHEDNEREKDKERQRKKFERDNEKLRSEDQKEMKPQELDDRLNDVDEKWKTIQNERRSGKPDVGKKSESNLLTSMQKIEDRLEAFRVNASNKDEIKDVSLGTSKINYIDPRITVAWCKEYDVPVEKVFAKTLLTKFTWAMETTPDWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H1</accession>
    <name>I4Y6H1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960361.1">
        <property type="nucleotide sequence ID" value="XM_006960299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H1"/>
    <dbReference type="GeneID" id="18474503"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61390"/>
    <dbReference type="HOGENOM" id="CLU_2795884_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6H1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="68" mass="8024" checksum="A3CA77AADE1F1B6E" modified="2012-09-05" version="1">MKVNKVDKKIKEITNTMTRNEGYITKMTSINERQKTIIRSQMLERRTQKSIIQNALRGINNVTEKEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K6</accession>
    <name>I4Y6K6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_70513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960396.1">
        <property type="nucleotide sequence ID" value="XM_006960334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K6"/>
    <dbReference type="STRING" id="671144.I4Y6K6"/>
    <dbReference type="GeneID" id="18475752"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70513"/>
    <dbReference type="eggNOG" id="ENOG502S31Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451441_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6K6"/>
    <dbReference type="OMA" id="IYGEMSE"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="4">
        <location>
            <begin position="513"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="605" mass="67530" checksum="570AF38B58CABEBA" modified="2012-09-05" version="1">MYKSSPPASPSPTPRSHTSHSRQSSISTPGQQTIQFADEERERRRAEECFNNQLEGFTLQDLDYDDYYDYSVEYGRNDYGYTPSKASEGHPTGSTPLKDIVNGSTPAPASSRALLSKELDRLISNKPVNPSPFNPSRFGGTTYEDTNHSRTLDGARLPDLTGLTYATASPDKGSTHKLLSSKRTRLGREDEQVILNSISNLEHKLNALNAENAQSKERAQELENELIVAKREVARARANSAQEAEQEWQAKCKILADEKRALEEMGKTLRSIVENLKGELSSQSKVIDQLKEDRSANEAKLVDKDKQIGWLNGQVSKLNKDVDGLWKALNEGKQKEEDNLRKEREAREEERVDERRRAVNAAQSVQEKSEEAPPKLVLRPFGAHLRPDPSPQSFFSPTRDRAARSHPSTETAPADQPKQQEAEDKASPVKEVPAINIEETSVTATPRTSKRSTKEKPGIYWTLPASTGSTTKTTRRSSAIVPPPTPSLEQKVNDEGFVEGLIERMGKSSSGWESKVPPQTVLARVVRELEDDFAHYRGIYSEMSEQFKVLDPASNAAKRRVLTQHLHQVITVLESKADQISSLYQLLKYGDKSVSKTPSKKTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6N9</accession>
    <name>I4Y6N9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960294.1">
        <property type="nucleotide sequence ID" value="XM_006960232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6N9"/>
    <dbReference type="FunCoup" id="I4Y6N9">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="GeneID" id="18474484"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61365"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009187_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6N9"/>
    <dbReference type="OMA" id="VVCAWAF"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="201"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="387"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="963"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="975" mass="110761" checksum="71E7A21F752EF398" modified="2012-09-05" version="1">MVNFADISQNALETFNSSKHVDASAVWLQFAVMTGISLLTIIVFSLLRPRNKLVYAPKAKQSLEAIKHLPALNDSLFSWVKPMFTMKESQLIDKIGLDAVTFVRFLRLLCEVFICIVIICCGALIPVNMVYNYKNINESDRTWLDSTTIMAVGGRVLWAHCAASYVIVAVVLWRIWVHTREMVALRNEWFRSEEYQTSLYARTLMIQNLPRKLMSDQGLLSILKSDPNSISKKKKRAIDIPYEFSSTHVSRKVGKLPTLIEKHNDAVRRLEQTLTTYFKKGTIMNRPRPLHRIGGFLCFGGQKVDAISYYTEKIKRYEMEIDSTRNELDFKRPDNFGFASLVSIPAAHTVAQKCENKHPHNTTIQLAPNPKDIIWKNLTHPPSKLSKLWGWLLLAFVCFLNTIPLIFISFLANISATAVYFQGLRDWQSSSPWTFAIMAGILPPLVAGLFSYYLPIIIRKLTEFKGAATESRLDRAVIARLFAFLVISQLFIFTLISVGFHLISDIVSQVKKQNSFVDIVKSMTTLPESIESAYVSQSSYWLKWFPLRGFLVFFDLAQLGNLIFIFVRTHVFGRTPRDIKEWTRPPPFEYAVYYASMLFMACVALIYAPIAPLVAAAALIIFLISAFVQKYQLMYVFITEVETGGRIWNVIMNRLMFGLIAMQAIMLLSLGLKMGWSVGKWAAAIPPIIAIVVFKYILNRKFSKQFNYYLPDNEEAATSKVHNQKSDVKRGRLAKRFGHAALHADLFTVQVHDKHVHLLEEVLPESTHKTSNFKDEIIADGLKYEAVTEEQLEELPNRDRGELDWDVRSLTSTVLPGSIDRHGAGTPGSTYSYYQSTGPRIPFAGHPMGMPSITESSDSFPPPPPHPNDFNVSTGSLHRMEDSFDKPLLDSMKKGTDAYHYNHGTYSPVNLNEEEDEDRTPRISSFAREESQARRRYSFESTDSSSVYSASDAHTRLTVTNQSPAPEYSEYPPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Z3</accession>
    <name>I4Y6Z3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960243.1">
        <property type="nucleotide sequence ID" value="XM_006960181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Z3"/>
    <dbReference type="STRING" id="671144.I4Y6Z3"/>
    <dbReference type="GeneID" id="18474473"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61345"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6Z3"/>
    <dbReference type="OMA" id="RLNFFMW"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="23596" checksum="6A6BAF3BBF471CFF" modified="2012-09-05" version="1">MMMLVYSLVGQNNSIRNEYNASTRDYSQIVEQVMEKIPPNNSKLTFKYKDININYLSDNGIVYLVISQDSVSRAVAFKYLLDLQQKFTSVEDSDVDFTDTIKDLLESYNTQPPEDQLGKTQNELNQVKDVMIQNMESIIDRGDRIDNLVDRTNEMSSQAFAFRKKSTMLRRQMWYKNKKIQLLTAFVGLLVFYFFIHSFVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y748</accession>
    <name>I4Y748_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_70317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960124.1">
        <property type="nucleotide sequence ID" value="XM_006960062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y748"/>
    <dbReference type="FunCoup" id="I4Y748">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y748"/>
    <dbReference type="GeneID" id="18475713"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70317"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072604_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y748"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="86"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="33912" checksum="25F06424BCA85F5F" modified="2012-09-05" version="1">MFNPFEAAQGGGGDDKTFLGENQPHRPTTGALRYSDDTEFNDALRAQGIIPQKPPSRPSTPEGLDIDYSQIRNAGLSLATEDTLAEAAEEADDSEDERVLLSYRKKRMEEMRKLESTARFGRMYPIARPDYTREVTEASKEHTDPQFNPNDDSIENLKRGGTSVICFLYSESIEESRIVGQHLHALASDYPHTKFVSIVGSQCIAGYPERNCPTLLFYKRGTLMKQIVGANDPTIGLHGKQTTKKDVENLLLAMEAIKLKPVNTNAHDFAKKDEQDRDDDDYDSKPTHIRQGAQDDDDSDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y755</accession>
    <name>I4Y755_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">sterol 3beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_40807</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960131.1">
        <property type="nucleotide sequence ID" value="XM_006960069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y755"/>
    <dbReference type="STRING" id="671144.I4Y755"/>
    <dbReference type="GeneID" id="18472192"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40807"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y755"/>
    <dbReference type="OMA" id="SAMAGFH"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="168"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134660" checksum="F15B9F93B33A7595" modified="2012-09-05" version="1">MRMGTQSLIQVIQAFAHHADDDSNDDDEDAQEDTQDHRVFDMYSSLNTVHNKPQTHLHESMSTSMSGTPHESQDEDEEAGSDRSAHSDDSELTRMRSQSLKKKSTQRRRNLSKKLSEIFDLDSQEDIKAEYRCSLLGSSYRPLLEGFLYSTNSFLCFFAHVPTLERNNVVKTGPIGKRTLRTRRVIRYWLALKDDVLSWFGSAIDPYFPVGNVALRYAIRCVTVKNSDREFTIFTSERKFTFLADSKTGRNEWVKVIRKGMFRSQNESGSFKLVIPYDHVINVERSSNLEFADSISVSFINNEDGADYYYFDHFRDSQSACNTLSEILETHRHDVHRILSNENLVMSPTKMKDEFIDGSEVTARPSSSGHIGNHTYPPSNTKNSRSRSSSLTAEIPSWIKSGSIKLGKVVYSAPRMIPHPHLSTILPKLPSIPFLNNNNSNQGRQQPLPNPALTNQLMRTNSRVYEHYEEPTNSRSNDNNRSRSNSGVAESDDEFEEVGSDFSVLEHSAGMEDILKVEEEVQRKFNDYFALPGEKILGHFNCALFRVYPTPGKVYITNNYLCFRSFQIWSRTKMILPLNDLQAVQPHKPLRFSFHGLIMIIHRHEELFLEFTTSNRRDACEKLLNTQLDKIFRSASIQQTQSSKGLQEAQIIEDLSLSYRHPSLTAPVLGEEGVSPSTSVVSFKPKNPLRITCLTIGSRGDVQPYIALCKGLIKEGHHCRIATHLEYKDWIENYGIEHREVGGDPAELMQICVEHGTFTLSFLREGLFKFRSWLDDLLKCSWEACQGSDLLIESPSAMAGIHIAEALQIPYFRAFTMTWTRTRAYPHAFAVPESRMGGSYNWMTYTLFDQVFWRAISGQVNRWRRSTLGLTGTNLQRLAQHKVPFLYCISPTLVPKPLDWNEWIHVTGYWFLDSITPENSENSVNDNNGKWDAPAGLLEFIAQGRSLNKKIVYIGFGSIVVSDPDEMTKCVVEAISQADVYAVLSKGWSDRMHTGKKEEKLLFPPSIFSIDTIDHAKLFPMIDAAVHHGGSGTTGASLRAGLPTVIKPFFGDQFFNADRVEATGVGSSVRKLTVETLSKALKTATTDEKQIANAKTVGEKIRNENGVANAIECLYRYMDYASTVITTRAHENLQHDDGIDAQDIEDDDDWSLPSETFSEDEAQRSMGVLSLATNIGKRSLGVGKDLITKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7S8</accession>
    <name>I4Y7S8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_21308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959950.1">
        <property type="nucleotide sequence ID" value="XM_006959888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7S8"/>
    <dbReference type="FunCoup" id="I4Y7S8">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7S8"/>
    <dbReference type="GeneID" id="18470882"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21308"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y7S8"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="16804" checksum="1BBE3449BDC828BE" modified="2012-09-05" version="1">MPAKNASQTTNKALSARKQTLKGGQTNKSRKVRTQVHFYKPKTLRLPRDPKYPRKSIPSRGQLDQYQVIQLPVNTEAAMKKVEDDNTLVFLVDRRANKRQIKDAVKKLYDVDAAKVNTLIRPDASKKAFIRLTPDHDALDVANRIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T7</accession>
    <name>I4Y7T7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959958.1">
        <property type="nucleotide sequence ID" value="XM_006959896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T7"/>
    <dbReference type="STRING" id="671144.I4Y7T7"/>
    <dbReference type="GeneID" id="18474386"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61194"/>
    <dbReference type="eggNOG" id="KOG2097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550057_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T7"/>
    <dbReference type="OMA" id="FWATYDT"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="500" mass="57101" checksum="83B3A5A52E2C2842" modified="2012-09-05" version="1">MISSEGDALLRYHVMKRNNEEEYLAKLPEDKKQKRKVYGQRYSLTDEESIRNDYSMAYVNQLVRPQDQIINPHREGRFAEYPRQKQLLKLKDSLVEEYAYPPVYLPFDLVDAIPKSPTTPSSLFDAIDIGTKFDVIMIDPPLPNSRSSKLEGRQWTWDALATLPIRNLSADPSFVFVWVGSGGEDGLEKGRELLAKWGFRRAEDIIWVETTPEGHKEEDTSDVPDNLFKRTKQHCLMGIRGTVRRALDSHFVNCNIDVDTIIAESASRKPSELMALIETFCLGTRRLCLFGEPENARRGWLTVGMKGSNNETYSPPEGVDMFDSKQWSERFPNNKANLVPLTPEIDSLRPKSPNRSNNNSRNGTPKSDPRTPPFATRPVGSPYGTPPNMPYNPQFNAQMRYHMQQQMQQQMQQQVQLQIQMQLQMQAQQAHMQMFGGGNLYQGVQAVPQMYYPPVNTTGTIYPLSPQMPISLGFDGNTNNRRHAKTPSNSNQNNINRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Z4</accession>
    <name>I4Y7Z4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_48009</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959807.1">
        <property type="nucleotide sequence ID" value="XM_006959745.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Z4"/>
    <dbReference type="GeneID" id="18472437"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48009"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="InParanoid" id="I4Y7Z4"/>
    <dbReference type="OMA" id="DMMIYQR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CATATPASE"/>
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    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="455"/>
            <end position="475"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1102"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1130"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1179"/>
            <end position="1203"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1215"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1243"/>
            <end position="1268"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="1067"/>
            <end position="1317"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="588"/>
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            <end position="1382"/>
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            <begin position="1402"/>
            <end position="1453"/>
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            <end position="243"/>
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            <end position="1441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <evidence type="ECO:0000256" key="1">
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    <sequence length="1453" mass="163983" checksum="645C5020CD779826" modified="2012-09-05" version="1">MLQPKSMQNVGSEWIYTTNQIISSKYTVLTFVPRNLLEQFRRVANLFFLGIAILQFFPKFSTINGGVVILPLIIIVFITACKDGYEDIKRHQSDRKVNHSKVQILKGTHGAAHHSEYHYHNFNHVEAKSKTFTAGLPKNVKLGKLRLKKKSKTSDHLPPPTVPDAVTSLNDEAKFENDQGAYGISSPPELNDTRDFDGRQMGLVDDLENPRTYTPPPAPAQLPTGPIVEDDEEFGEEDDEEDEAGNKWKTSLWEDVKVGDFVKINNNEQFPADIVICSTSEEEDVCFVETKNLDGETNLKSRHAIPQLSHFRSPSTIARDCHGYRIDSEAPDVNMFKLNAAVVKEGTHPTKSPVDMSTVLLRGTVLRNTKWVIGVVLFTGSDTKIIANSGITPSKRAKTERLMDPQVGINLALLAVMSAFCAIVAYTIEVSDQRNGAYWTIRDDRPGDNPSANGVFTFFNGLITFQNIVPISLYISMEFVRTCQAGWIYLDKDMRYKKNGYRAVARSWNLSDELGQIQYIFSDKTGTLTQNSMIFRQCSIAGKIYKSDDTTVVESKLTSSPQMPASIVGSETPLKTHSSSNSSDGYEAQINEHTDGSQVDSEATVKPKFYSSALHTDIRAEGGGEEAEKRGQDVDAFLTCLSLCHTALASEQEDGSLDYKAQSPDESALVQGAADVGYVFKGRDRNILKLQTPFTNNNVDYYELLNVLEFSSARKRMSVVVRKLSQSRAQMKIDVANNVAQGERNPQIPLDDDDEEDSEIVLLTKGADNVIFERCEDNIQNRGMKDVTDKDLSYFASEGLRTLCLGYRVVPSEEYEEWNRKYNEATVALDNREQLLEEEASRFETNLTLLGATAIEDKLQDGVPETIRDLKRAGIKVWVATGDKLETAIAIGYSTQLLTNDNNLIIVRGGGYGERNSAYAQMRRAIDQFFPEESIPSRLRNQPPDNGYDNMKRSSTHSHALSGIESLVGADNGQRDGGYALVIDGMALSHALSEPWSKDLLLNLALKCKSVVCCRVSPLQKALVVRLIKDNLDTMTLAIGDGANDVSMIQAAHVGIGIAGEEGLQAVNSSDYAIAQFRYLKKLLLVHGHWCYYRNSNSILNFWFKNIIGVGVLFWYQFFCAYSTSYVFEYVYLLLWNVFWTLCPVIGIGLFDRDLNDKVLMAIPELYKYGRKGQYFNSWLFILYMFEGILQSTIVFFFTYYAYMSPTTRADGYDTYVYEMSTTMVIAAVTGCNLFSGLNVHAWTWWIVFGVFFGIVFIWAFTAVYSALSPQLVWTNLWGNEELVFHSALFWFCLIFTVIFSLMPRYVFKAYKFQFHPDDINIIQYVQKKDDDHDFENDPLMQSHLRNTYTKDNEYPPNRPSSVRSGQRIDMSTGQRSTGRNQTFGFDQEENGYAMQRLQSHLSETSSQFHRRPSANDAEIQSRRRKFKRKTNSWTSRTVESFKTALPRKSKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y817</accession>
    <name>I4Y817_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EIM20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006959768.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="RMNTANT"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="P:mitophagy"/>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
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        <property type="entry name" value="Atg13_N"/>
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        <property type="entry name" value="HORMA_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
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            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
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            <end position="276"/>
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        <location>
            <begin position="529"/>
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        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="386"/>
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    </feature>
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        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="549" mass="60278" checksum="0D9520913DB3C17F" modified="2012-09-05" version="1">MSDHSKVDLILNNFYSKTLHLLLESRVSLPETKSRISKWFNIQTTDSGSNLFKSELSTWKNLSTSTQVPPMVIEFILDATDIPPNQACLFVDTQGRRNTVQSSLVLERWTLQLSGAGAQEDLPIVYKRSIVLFRALYTLLRVLPLYTFIRRLRRSHSRGLNIGCRLSAEYSKPTQSDGILPIDAQLSQDPQSNLTDTHRFNTITTPAGILNLSVEYRCHTNFVVDDIESLLSSRFVDEDYYTPTLTKHRSTPSAGSSGTSGVFPIPAVSDENKEEGNVVRDYVARTGASRVRANSSLSPRTTSYFSTSPSVRPMSLYSGASPTPSLTGIVAQSYQRQGAAISIPENQSSSSSTTRRYSSSFGYRRNSSIGGGSSGESLIKPLASPNQPSPPPSGVTVSRKQSTKLSQSLAEEEGHDDKDIGEFIKLIDQKPQLRSVQETSSATISKQQLDEKIRMMSVSSLANSSVKEEEKQDFGEVVGQMDFDELDIRRSMSAPIATTSQTKLHTGVATALTAAGSPDDNAVPFYYDVGASRGRSSSRRNDKENPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A3</accession>
    <name>I4Y8A3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dbl-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_47842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959683.1">
        <property type="nucleotide sequence ID" value="XM_006959621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A3"/>
    <dbReference type="STRING" id="671144.I4Y8A3"/>
    <dbReference type="GeneID" id="18472430"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47842"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016275_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8A3"/>
    <dbReference type="OMA" id="YERGDEM"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="636" mass="72034" checksum="A6E3606888206C58" modified="2012-09-05" version="1">MVQFDLVENLSQRERTRQEVLWEIVASEARYVDDLSSLFEGYIKPLLYPYTQNKDSISIPENFKLLLETLGNFILPNHVSLSKDLKTRHAAQYPLIRSLADIFLIHSHNLQYYSLYVLHLEISLSVIDESINLAKSTGNMNKRSDLYNSWKLGKRLLDLEDAAQRDNEAGLAISLLKPFQRLLKYPLLFRNLLFNSDPSMIEYESTLKMVDQVESIVRSIEDRKIQIEERDKTRDVLARIEGIEKERSLMAPKPGRLLMKETSLQVPNKSKHGSLPPPQKPQVAKKTSVRRLSDLLPSGTTIHLEDKNNFTKKDLWHVEFNDVTLLCQRTARTTLPIASNDKSTPSVKRSSLSSNRSDSLRQNGRNLYRFIKIAKWNITDQSNEGIVSMNAILRSRSNSTDVGRQQIPGKPFPTSNPDSRSPTLNNVDNSTPDDMKSRASTKMSFSYAKGDEITPRIKLRPRQMPHSQKNSQNEIQNVRMAAAKFGTRLRPSNASQTSINVMNDRPSSRATTTGAPMRQKEVVVARTLTPQPPPTSSKAKLETMNSSTRKVNHRKAQLYNERSPSTSPAHKKHTSTGDIDASPTGSISSTSSMETQTNVRQPLQRKSRAPSQDSGMLLVRVAEQYLRESEPEVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E3</accession>
    <name>I4Y8E3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959723.1">
        <property type="nucleotide sequence ID" value="XM_006959661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E3"/>
    <dbReference type="FunCoup" id="I4Y8E3">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8E3"/>
    <dbReference type="GeneID" id="18471688"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33472"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8E3"/>
    <dbReference type="OMA" id="IYAQCKT"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="33223" checksum="91F7C5E412A9DB03" modified="2012-09-05" version="1">MSEVKVPNFSVSDYSKFFSAGAICCTLSHGLMTPLDVVKTRVQVDDAFKGMSLVRGAKQVIAKEGSSALLTGFGPTAIGYLFQGGLKFEMYEYFKRLSVLSVGSHEEAVRKRTPIYLTSAACAEFVADIALCPLEATRIRLVSDKNFANGMVDGFLKLTRQGGLRVLYAGFTPLLAKQVPYAIGQFEVNEFCHELVNKSLGEEKRKAIRQSKSAELSLTLGCGIVAGVGAAVLSHPGDTLLSKINKNPDPTRSASAQLIHLAKETGFRGIWSGLGARTWMTAGLVSSQFFMYKAIKDALGAPAGIEIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I0</accession>
    <name>I4Y8I0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_55206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959760.1">
        <property type="nucleotide sequence ID" value="XM_006959698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I0"/>
    <dbReference type="FunCoup" id="I4Y8I0">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8I0"/>
    <dbReference type="GeneID" id="18472719"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55206"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8I0"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="294" mass="33768" checksum="5674870F294AC4C2" modified="2012-09-05" version="1">MLRTVKPKNARAKRALKEREPQLSENPKTALFVKTQTTSAIVNEAMSDLYSLKKPNGLNFNKKNQVTPFEDASSLEFWSNKNDASLLLVGSHQKKRPHNLIFTRTFNYQLFDMFECGVENFKPMKDFNIHNQVNVGMKPLFNFTGELFDSHPKYQHFKNVMLDFFRGETLSQISLAGLSHVISCTVGEQADENDLPTVHFRVYSIQLLKSGTRTPRVELVEMGPSMDLTPRRAQEADESLNKEAYRRPKPVNVPKKRKNIDVDEMGDKVGRIHMEKQDLSKLQTRKVKALKPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R4</accession>
    <name>I4Y8R4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_33406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959613.1">
        <property type="nucleotide sequence ID" value="XM_006959551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R4"/>
    <dbReference type="FunCoup" id="I4Y8R4">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8R4"/>
    <dbReference type="GeneID" id="18471674"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33406"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8R4"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000073">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000329">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="161"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="695"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="932"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129940" checksum="A189FDDB983CA1DA" modified="2012-09-05" version="1">MAERQELTSYTAPKEILEEFNQQIEEEDHNPFADTIKKKQIAERQSDYHNRRFNRGEGDLSNDNFSGEGVEGSSYADRMRQNELDKEEARVRKIIEERREQQEAENDGKQVQPLDGDKTPPREAFKVENDATPPKEAIRERKRRWDVAPEQVDQVKQEEPPKKRRSRWDEAPAEATPSETKPRRSRWDQTPSTNPVHDKTVADVAAMLPPALMGLPAVPLGLDPFSAQNSSARNRYITDEELDILLPSEGYAIVPIPEGYQPLRSSAHKMMSAIPMDTGFNIAEKGVSAETLGISTGDLPTEIEGIGSLAYLKPEDAQYFGKVLQGEDVEPGLSMEELKDRKIMRLLLKIKNGTPQIRKSALRQITEKARELGAGPLFDRILPLLMERTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDYFARVEGREIISNLAKAAGLAHMISTMRPDIDHMDEYVRNTTARAFSVVASALGIPALLPFLKAVCRSKKSWQARHTGIRIVQQIAIMMGCAILPHLRHLVSAIAHSLEDEQQKVRTMGALAIAALAEAATPYGIESFDAVLKPLWLGIRKHRGKALAAFLKAIGFIIPLMDSEYASYYTKEVMVILIREFQSSDEEMKKIVLKVVKQCAGTDGVEPGYLKEEVLPDFFRNFWVRRMALDRRNYRQVVETTVELANKCGVMEIVGRIVNNLKDESEPMRKMVMETITKVVENLGAADIDERLEIQLIDGMIYSFQEQTLEDAVMLDGFGTIVNALGSRIQPYLLQIVSTILWRLNNKGAKVRMQAADLTARLAVVIKTCNEEQYLHKLGVVLFEGLGEEYPDTLGSFIAAEAAIANVVGMNEMQPPVRDLLPRMTPILRNRHEKVQEATINLIGRIADRGSEYVPAREWMRICFELLDLLKANKKAIRRAAVNSFGYIAKAIGPQDVLSVLLTNLRVQERQSRVCSTVAIAIVAETCGPFTCIPAILNEYRTPDLNVRNGCLKALAWVCEYIGELAKDYVYALVGCIEDSITDRDHVHRQTSAAIIKHLTLGVAGFGKEDALLHMLNLVWPNIYEVSPHVIGAVMEAIESMRVGLGPGLLLNYTLQGLFHPARRVREPYWRIYNTVYVGSQDALVPYYPNMEEVGNERNNFKRTPLYMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y903</accession>
    <name>I4Y903_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis, uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959471.1">
        <property type="nucleotide sequence ID" value="XM_006959409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y903"/>
    <dbReference type="FunCoup" id="I4Y903">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y903"/>
    <dbReference type="GeneID" id="18474251"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60921"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y903"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="257" mass="28651" checksum="D6901D5749E0E3E8" modified="2012-09-05" version="1">MRVLLFKEETSNYKDALTEGGYDTLFIPVLRSISVDIPRLRELIHKSAHDYDAVLVTSQRAVQAWKEASIGIDSPISWSNIPFYSVGPSTSNALQTLKDTINPDLAPRDVLGGEESGNGNQLAEYILSREEKPRRILYLVGDKTASELSNILQDHGVEITRLQVYATQQIASEEIETTLKQKECTDTVWSVIFSPSGANVIVPAIKNLKLDTKLASIGPTTTRRLQEMHMNVDAMPARPDARQLTEEMHKSDTVDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y940</accession>
    <name>I4Y940_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_60937</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959508.1">
        <property type="nucleotide sequence ID" value="XM_006959446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y940"/>
    <dbReference type="FunCoup" id="I4Y940">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y940"/>
    <dbReference type="GeneID" id="18474263"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60937"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="InParanoid" id="I4Y940"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="437" mass="48565" checksum="144C8DB82E4E690E" modified="2012-09-05" version="1">MSTSNSNFLDKAIDLVSNAIEEDVKTNYAEALRLYLNALDYFMMALKYEKNPSLKTMIRGKLVDYITRAEKLKQHIAKSDENKKQPLGSTNSGGTNPGQPGKESENDDAETKKLRAGLSNSILQETPNVSWDDVAGLEVAKEALKEAVILPIKFPHLFTGNRKPWRGILLYGPPGTGKSYLAKAVATESKSTFFSVSSSDLVSKWMGESERLVKNLFAMARENKPSIIFIDEVDSLAGTRGDGESEASRRIKTEFLVQMNGVGNDDNGVLVLGATNIPWSLDVAIKRRFEKRIYIPLPEPEARKEMFRLNVGETPCRLTQKDYRLLAEKTDGYSGSDIAIVVRDALMQPVRKVLSATHFKEIYVDGEDGTSNRKLTPCSPGDPQAFEGSWSGIDSNELLEPDLALNDFIKAINSTRPTVTDEDIRRHMEFTNESGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y988</accession>
    <name>I4Y988_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mon2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959327.1">
        <property type="nucleotide sequence ID" value="XM_006959265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y988"/>
    <dbReference type="STRING" id="671144.I4Y988"/>
    <dbReference type="GeneID" id="18475622"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69690"/>
    <dbReference type="eggNOG" id="KOG1848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442925_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y988"/>
    <dbReference type="OMA" id="RWERHEV"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2 C-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="617" mass="71810" checksum="B9CA0A3D5CD9EDB6" modified="2012-09-05" version="1">MWLQSLSCLTRISDHLQNKIKRDSDNQAYLKLWIDLLKELKDLGLDDKEEVRLGTISTLFQSLDFYGHTLSSQSWEQIIWDVIIPLLDNTLSSGWHESLTLALDSTASLFKNYLHSNIKHLESFNKLWKHLCDILEQVMLVADNQLVSSTLKAFISIEEVFKQEELDNDIYQVSWNTSLKSFDIIKSTDSQFAQEGLELLLRFIKYHYDSQGSTWDDNRCVEYIKSVDFVIRYPNYSNFRADTDHLTPLQNQSLKCLASVEEHSDSIMSTVLEIFSEWASFAYDNDLVLNSRVSFVALSKHIMGNFTSYVRQYCLTGKKVITSSSLRASLIALSIPLRIKYSCPPASKRDDITLWEIAQDHYCEYTHVVLEILQQQKSIMEDDEQMNIIICLIEIMRDSFKVDRRLAMNEPLERQARWEKHEVKLIDNFKDTLLPQLRNRNLPETLIDELIGVLCNATYPYLNPEDYKYGSLIEETTSPVERLSYYLFDVLFDICEEKLDLLDLVPIVQKHIISRCIASFERYCCDRDIHGNYPLTRCRRYEIVYILNKLHSLLISKKLDKTLVQELKLTLAKLLAIIHNDPFNPRINSQPSSILNIESKQLSHNIHQLALNCLSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9B2</accession>
    <name>I4Y9B2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959348.1">
        <property type="nucleotide sequence ID" value="XM_006959286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9B2"/>
    <dbReference type="GeneID" id="18475001"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65226"/>
    <dbReference type="HOGENOM" id="CLU_1846684_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9B2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="15993" checksum="5015B1F53BA3130F" modified="2012-09-05" version="1">MLFNNLAKIYFDHFNLIDSNLNRTSSSISNISATLADISQYQYNTLEKSLFDYLTSFNYVTNYDYLNISIKAIFELLRAILAGFTTIFVIVAAGSLTCIKGFMRSLFRYSPKSRKLRARRLEQRSSKVKEGLRYNSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F2</accession>
    <name>I4Y9F2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_69744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959383.1">
        <property type="nucleotide sequence ID" value="XM_006959321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F2"/>
    <dbReference type="FunCoup" id="I4Y9F2">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9F2"/>
    <dbReference type="GeneID" id="18475637"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69744"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9F2"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="21312" checksum="7E97650546B8AE2C" modified="2012-09-05" version="1">MRNLKHHEQKLLKKVDFLNWKQDASLREIKVMRRYHLQGRDDYNKYNRLCGSMRQMAHRLSLLSAQDPYRHQMETQLLAKGYEMGLLNIGSKLSDVEKITVASFCRRRLAVVCVRNKLCESVKTATQYIEQGHLRVGPDTITDPAFLVTRNMEDFVTWVDTSKIKRTVMNYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M8</accession>
    <name>I4Y9M8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_47137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959204.1">
        <property type="nucleotide sequence ID" value="XM_006959142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M8"/>
    <dbReference type="FunCoup" id="I4Y9M8">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9M8"/>
    <dbReference type="GeneID" id="18472409"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47137"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9M8"/>
    <dbReference type="OMA" id="NRKMCII"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="195"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="291" mass="33564" checksum="2659956704617BEB" modified="2012-09-05" version="1">MITRSRTGLYLSYRDSALHNFTQEEDHRLLDDEVVIDLDKLPPQWVDITEKINSILQSTRNKILSLDKLHQKRLLPTFSDRSQEEHEIDTHTEDITNDFRSCHSLMSNIQIKGTIDQVRISKNIQRAQATKIQELSGLFRKKQRIYLEKLKGHTIKDADILAASGKTHDNIQSLQDDEQLSQMQLNSTQLQLQDDAQLNKRDLEINNIAKSIAQLAELFRDLNTLVIDQGTMLDRIDFNAQGTKTQVDSAVKELNQATKYQRSSGKLKCIFLLILLILLIIVLIIYKPHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U1</accession>
    <name>I4Y9U1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_65153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959264.1">
        <property type="nucleotide sequence ID" value="XM_006959202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U1"/>
    <dbReference type="STRING" id="671144.I4Y9U1"/>
    <dbReference type="GeneID" id="18474993"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65153"/>
    <dbReference type="eggNOG" id="ENOG502S9M6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094309_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9U1"/>
    <dbReference type="OMA" id="RFNGHNK"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="155" mass="17907" checksum="8805536257409090" modified="2012-09-05" version="1">MAPHVTPEEFIKDLTELFRLASDSGTVFLTQKRYDYNENADSNMNNTADSQYDVLLRASAQVGDKQHKTATRIASTQLDSFIGQYNSLLHQSLQAKMRKRDRKREKRKADIAAIRKRKLETPTDIPKTKRGAGRRKFQRKVKAEQKRVQTLNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA03</accession>
    <name>I4YA03_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60704</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959060.1">
        <property type="nucleotide sequence ID" value="XM_006958998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA03"/>
    <dbReference type="FunCoup" id="I4YA03">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA03"/>
    <dbReference type="GeneID" id="18474111"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60704"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA03"/>
    <dbReference type="OMA" id="NPHGGKE"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="314"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="470"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="599"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="809"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1104" mass="124583" checksum="F91E831B3AABAC4E" modified="2012-09-05" version="1">MVKRNREVASGSESESDFDYENMGNYEEPNEFEDSGEEQMDVDDANIKSNGGAFKAPTKDEVQSLRETGELFKSNFFKLQIDSLLEEIQQPASQVETLTQALHALRNLIMETKPIGKSTDGKLSTSDARKYLKKNNLSLPVSKELPEDVNWAVGYTVPDIVQVAGSWPLKTNVKRRSSRVKSWEVTLAILLPSHFIQEKDHQNDRWLFKQAFYMTVLADILKKSKLDIQVDITQANGSELEPVISITNKKGSKFIPSNTTINLVSALASPTPFKPLSKISPSRIGSKLSNAFMKPSLHTPHLTYLYNIAETVPAFRDAVKLLKVWANQRSLDWLLNGFNAEFVVALLVDGDQDGKGRVGKGLSSYQLFKTVMDLLRKTDFTSVFMKSITTGGFSKEDHFNSTPLLFIDPTHTYNLMDGLLPEDARVIGFEAQLTLNALDDDNDRFEDTFMKDLRNPTARFDLIGKGKLPSKLVKKIAKGTNVRQNIAATLARALGERSKVINVKLDDDMISIGLILDSEVAGKIVDHGPPAEDEEGCEVFKAFWGEISELRRFKDGKINESVVWQQSNGSKELVPIQIVKWILRRHFNIDQLSFIAEEFDGLLEVEAVDGVETFNDFGAPLQVYEDFQSMLRDMTTLPLEIMNVTPASAYLRHTSPYPQPTRQMNKFGVTPTSARYIPGADLVVQFESSGKWPDDLEAIQITKVAFLEALAAELMKSGQYMAQIVFDSPLPSDIADAVALEVINEQGFAWKLRIQHDRELTLIDRQLNDKVNTTNSQKEILKEARHRFLERFVNKPRHHQAIMALTHRFKAYAKTVRLVSRWINAHLLSPHISQEFIELVVASVFLDTGSYSVPCTPSLGFLRSVLLLSEWKYKQEPLLVPLYTASQIQEDHLDRKIVFPLKEKTEAEKTFEVLRRTDEDIKKTAMFVATEHDVSGGHYTHDRPSKVIASRLQSLAKATASALLDDSEVDIMQLFKSPTEIYDFVINLKSWVNTRLYQSLAEDNFGDVDTSNDALVNYDPATMFVEYMERMYGDVVVFFHDACGGRVIGAMFNPAYTSPRKWKVGLHYPTKSVDSKDDVVIDKKFIIKEITTLGKDMIESVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA69</accession>
    <name>I4YA69_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959122.1">
        <property type="nucleotide sequence ID" value="XM_006959060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA69"/>
    <dbReference type="GeneID" id="18474134"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60742"/>
    <dbReference type="HOGENOM" id="CLU_673011_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA69"/>
    <dbReference type="OMA" id="CAIRSTH"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46583" checksum="27353BA0E69AA13A" modified="2012-09-05" version="1">MGAELRIDLPSSHNVITFGPHDPHKELRGIAHLSLPSARSIKSIDVEFKCVEEVHLSSGKEKHELLSERFNLYGQKVLEKGTHEFDFFFNVPNCFVYERHSHGTCHQFLYATVQFDEWIAFPLTHKLDLLFAAHPHGWGYIPFGESVQNHIDGLGPIEVAFNTRHLTVSCVIETTLHLPNAEKDLQIHGLRLSVEQSTILCSRSNPNLVEKLPPLTLPMLNIGSNKLTTNILPERLSTAYPIKGRYLARFPDDQLLRGSSFEFVDSAIKHQHKLLLEIWHSTYTKKQVFKARIAMPVRIPHCLLSFDSVLLPKYEDHVKTKQLRQNDKRDYAGIGKEKQESCNCTKTYEEAKAVAMSMYDIVSPIDRNTGVSNKEGFWISPEDRELTKKGDPPKYLYVPEEEHESMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC0</accession>
    <name>I4YAC0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959171.1">
        <property type="nucleotide sequence ID" value="XM_006959109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC0"/>
    <dbReference type="GeneID" id="18474158"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60777"/>
    <dbReference type="HOGENOM" id="CLU_006019_4_0_1"/>
    <dbReference type="InParanoid" id="I4YAC0"/>
    <dbReference type="OMA" id="SICINAA"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="469" mass="53950" checksum="C110771153385131" modified="2012-09-05" version="1">MPLLNELHFRKQMPRKLERPFGTILMLVAALGALYSNDNRLSIPGRENLKFLQGYYYYNIAVEKMPNYMKASAGLEDIQALILLQMYVQRGVHTKSSTMINGLTILLSQNIGLHYKFMNPNHDDIIEKEARKRAWWILYIIDRSNTACFGRSLLIKDDEMHLDHVEVTSKDPSDSIASIKYMNDIIKICQIHGQISHKLYKFRKSNVGENAILKMNDIATLNAKINDWINNVSINDEDIKDDTTYQFRANIKLAFYNAQLILYRPFMPCPKLKLPTSNFQTASLAICSNASRSIICIYSDLVLNRKVDRIWADCIISWCPFWATLIMILSYCESRRMGNIRYQDLDYIKTGILTLRGVESKNVLYGRAVDILLPIVKAILPPGDIFIEDQQLISFNTEFHSTVTANIIQLPQDNTNVVEQNDSFFRDMLDYLKSDSSNSVYSNNNFMITPEHENDLNMMINSMLDGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF4</accession>
    <name>I4YAF4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958939.1">
        <property type="nucleotide sequence ID" value="XM_006958877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF4"/>
    <dbReference type="FunCoup" id="I4YAF4">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAF4"/>
    <dbReference type="GeneID" id="18474075"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60653"/>
    <dbReference type="eggNOG" id="ENOG502QVVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_8_2_1"/>
    <dbReference type="InParanoid" id="I4YAF4"/>
    <dbReference type="OMA" id="GWFFWTL"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="93"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="513" mass="58682" checksum="5023F067DE447A18" modified="2012-09-05" version="1">MGIFKSIKNSFNKIDNQGGNAPATESYPTGNAIVPPRVLSPADVYRFRKQRGVNLGSWFVLEKWITWSPYNHAKSPAQSDHDVARGGNAQQIMEHHYENWIKESDFEWLSQLGINTVRIPIGYYHFSKYLGDNYLDGTDFEGLGHVYQNTINYIERAVDWAEKYNLGVHFDLHSAPGKQNHDDHSGRSGPAIKMWKSRNIEVLKEVLRFLVGHFHQRDNVVAIELINEPANNDQLQSLYLDLLGQIRTITHPHFPIAIGDAWDTNWYAQLAGGRKDFVILDHHLYRCFTEDQISSSSYDHAGRCKAEYLEFLQDAKMKARDSLIIGEWSAGLNPRSMLGGNHDEQRAMWARAQLELYEKTAAGWFWWTLRKEHGGDSGWDFKEAIRTNTLPHWLGGKQGLPAEGLATLEERDAKCDEATGQHAGYWETQNIPAREHWRFVDGFKQGWDDAVMFAYHRPGTGHVVGRSEIGFFGKWIEARMDEHFAYRGGSNNIWEFEHGWRQGHDAAVAALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ7</accession>
    <name>I4YAJ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958978.1">
        <property type="nucleotide sequence ID" value="XM_006958916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ7"/>
    <dbReference type="FunCoup" id="I4YAJ7">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAJ7"/>
    <dbReference type="GeneID" id="18474087"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60668"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_1_1"/>
    <dbReference type="InParanoid" id="I4YAJ7"/>
    <dbReference type="OMA" id="QCEFVYL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="36"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="330" mass="37334" checksum="DD4A985E7BB3DCB5" modified="2012-09-05" version="1">MAAAAATSPVINNLNPGQYVGFDSITRQIETKLLKRGFQFNVMVVGQTGLGKSTLVNTLFASQLIDSKGRFQPDEQSRSTTEIQTVSHVIQENGVRLRLNIVDTPGFGDLVNNDGCWEPIVKYIKDQHSAYLRKELTAMRDKYIVDTRVHACVYFINPSGHGLRPIDVIVMKKLAEVVNVIPVIAKSDSLTLTERESFKARIASELAYHQIKMYPFDAEDDERDEREINEGVRETLPFAIIGSQKTLNVNGNQVRGRKTRWGVIDVENEDHCEFVKLRNFLTRTHLQDLIETTAQIHYEAFRSKQLLALKNQANNAKPQEAASMQKIYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAM1</accession>
    <name>I4YAM1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_64909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958999.1">
        <property type="nucleotide sequence ID" value="XM_006958937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAM1"/>
    <dbReference type="STRING" id="671144.I4YAM1"/>
    <dbReference type="GeneID" id="18474968"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64909"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="I4YAM1"/>
    <dbReference type="OMA" id="YLFPNQA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="600" mass="66548" checksum="ABF5C5F9427F7115" modified="2012-09-05" version="1">MKVIGPLIALLVGIVYVRYRATSMTPSFEYVIVGGGTSGLVAANRLVQRGASVLVIEAGPDSDREDGVNISGMYGSMLNSHIDWKYDVGLKQPMPRGRTLGGSSAINFLLWNRPAEVEINAWNDLGVNGWDWDSLIEAMKEVETFNPPSEITNKLFGLDEPVDTSNYGHNGEIQLSYPRYATKMDEAWLETLRRLHIASNVNPADGNNVGANVSPITMNPSNFTRSYSASAFLKPVRDSSKLTIIDNATVSRVVTEKDSRGILNAVGVEYIRNGKKHSVAVLNKVVMAAGAISTPHILELSGIGDEEILKKYGIETILHQPNIGKNFQDHTYVASVFEVDSSVRNLDPVHFNPSIALEELAKYRSQSVSLLEQANVCVAYLTKDQLLDKEDQSELAELIKEVYLYEGEYKDQYLKQLEFLESDSVTQSEFINVGFFADVFNPPDVNKTYLTLLAANQHPFARGEVHIRSSNPLAHPRIQPNYLSHPIDVLFQKAASKYTRRIAWQQPLSAVVEREVIPGAHVQSEDDWEDLVKKRIFGEYHGIGTARIGKVDRGGVVDDKLRLHGANNIHIIDASVIPLHVSAHIQSLVYAIANKSLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR8</accession>
    <name>I4YAR8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_51633</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958745.1">
        <property type="nucleotide sequence ID" value="XM_006958683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR8"/>
    <dbReference type="FunCoup" id="I4YAR8">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAR8"/>
    <dbReference type="GeneID" id="18472565"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51633"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="InParanoid" id="I4YAR8"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="85"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="483" mass="52755" checksum="DF5B85F8366973C2" modified="2012-09-05" version="1">MLSKQLIQRLSTKSLASKNSVRAIQHTRKLATPSAPQGMATTVDAGSGPLSAPKDLDNKAIIAPLDSFGFNITAERKSTDPRRPIYLDAQATTPLDPRVLDKMLPWFTNQYGNPHSRTHVYGWESQDGVEEARAHIAGLIGADAKDIIFTSGATEANNMSIKGVARFNKNRKKHIITTQTEHKCVLDSCRQMQEEGFDVTYLPVQTNGLVSLEELEKAIRPDTSIVSIMAVNNEIGVIQPLKEIGQLLRKYKGIHFHTDAAQALGKIPMSVQDMNIDLMSLSGHKIYGPKGVGALYVRRRPRVRIDPLFSGGGQERGLRSGTVPAPLAIGFGEACRIGKLEMQNDHDRISVLRQRLLDGIIGKLDHVNLNGSETATYPGCTNLSFAFVEGESLLMALNDVALSSGSACTSASLEPSYVLRALGADDTMAHSSLRFGISRFTTEAEIDLVVNKIVGVVNKLRDMSPLWEMVQEGIDLRTVEWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS3</accession>
    <name>I4YAS3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mak16-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_69226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958750.1">
        <property type="nucleotide sequence ID" value="XM_006958688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS3"/>
    <dbReference type="FunCoup" id="I4YAS3">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS3"/>
    <dbReference type="GeneID" id="18475550"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69226"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007806_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAS3"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="10">
        <location>
            <begin position="150"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="9">
        <location>
            <begin position="869"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1174" mass="132388" checksum="6F6B87DB32087361" modified="2012-09-05" version="1">MNLLDTKSFHLRDFLDAISDNYNFDDKSVLLSQIQSTIKDLDSHSAHVQESRTKLQRTVKYAERQHLERTKELGRNFEAVGFSFLDLESSISHVGNTTVGIGEHLQVISDHRSRAIAARDLIQHYNTLARGNTSQLDSLRKSSGKDSRLNCAILLRRLSALSAVVDAPHAQNTHQLIDKYCEKFEKDMLKLFDKSYRKGDPKMMAHCAQTLLVFNGGASCMQVYVNQHDFFISKDRIGNADNSDNNAAFWNTLSDPDKQAPTVEPSLSALVDEIRSTVEQEAQIIQAVFPNPALVMQVFLQRVFAQSIQSKLEDLLEKAGSLSRFSFLRMLHISRMTISGLVEDLKKYDTLSSSVKTIGSGLVAPGTFAGPSGISTLLDQSLDELFVPYMEGERYISLECTSLTELYAGYLSSFTLYHNAVHSSKSTSMLDRVVNQLSETSSASSSAAALLKLSGKNNDDVLNTLDENDGKLSLDVAERMLKWHAESVGRCVDLTSSNNLSKNVFKLLQTLAESIGRSYVETAVDTTLFKLDNSRSEPPFECLEICSPADLITQLWQRYAATTIIPLTNNGAIGMKRELALFANNTISRLEVKLNAILQNLMDVVINYLGSCLQKQRKVDFRPKDDDTSFARINTEPCLLCCEILSFARESAVEALTGSNLEKFLIELGVAFHGLLLDHLKKFSVNPTGGLMLTKDIALYQETIANFNQPILKPRFEMLRQLGNLFIVRPEVLRAYMRDDIHLSKLDPAMLRPYLAQRSDYTMGLAKYLDKELGISQTSLVNGGNLYRAAWASLNNPSSTPPIPSKTPSPVPHLQRPKLASDGRKRPGTAIGGLFEQLEHLNIGLGLKAEDDEKEKDLQSSRKSPADDVVWQVINHQFCSYKVKTTTQNFCRNEYNVTGFCNRQSCPLANSRYATVREHEGVIYLYIKTAERAHTPKHMWEKIKLSSNYTKALEQIDSNLIYWPNFTIHKCKQRITKITQYLIKLRKLKSRQEPKLVGIKKKQDRREATREEKALSAAKLEKSIEAELINRLKSKAYGDAPLNVNEDVWRKVLESDKQVENEEELLDDESEDDEIDSEDEREFIEASDIESDLEDMEESGFIDQASSSEGEESSEESESSDDDDNDNQGEDNKKKRKLKPSNNTKKPIKRRQPHVEVEYENEVEPITKDSLINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT1</accession>
    <name>I4YAT1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SWIRM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958758.1">
        <property type="nucleotide sequence ID" value="XM_006958696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT1"/>
    <dbReference type="FunCoup" id="I4YAT1">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAT1"/>
    <dbReference type="GeneID" id="18474032"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60565"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004447_3_1_1"/>
    <dbReference type="InParanoid" id="I4YAT1"/>
    <dbReference type="OMA" id="QQFNEME"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="342"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="492"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="595" mass="66068" checksum="50AE9A7EA5F58453" modified="2012-09-05" version="1">MSEANSNGVTPIDPTQGKKHEAYPVVGGDISNISQNPESPAVEQENADVQMENAEENVVVKEQSKYHSQEEARNYLAAQTQEIIIPSYSSWFSFGQINAIEKRSLPEFFNNRNRSKTPTIYKEYRDFIINTYRLNPSEYLTFTACRRNLAGDVCAIMRVHAFLEQWGLINYQIDPDTRPAALGPPFTGHFRVTLDTPRGLQPLHPGTQPATKTSVKQEAPEIARQSSKPPNVELRKGIYNTSSYKVTEDPDETAKTANKFKASNDEGVSGEARYFCDVTGTECTQERYHSIKHPDFVLCPQAYLDGRFPSTMFSGDFIKITNDKYKPAGTIEDDPQANAEPWSDQETLLLLEGLEQYDDDWNSVAEHVGTRSRESCIAHFLQLPIEDPYLVASSDSARDPQYHGKASQGDLGPLAYGKFPFSQSDNPVMSVVAFLASIVNPSVASAAAKASVGEITKDESEEKMDVEPARNTVEKAASVALGAAAAKAKTLSNNEEKEIQSLVSKIVEAQLKKLELKTEQFEKLETMLEEEKKSLENARMQLAQERTEFAQQVKELQKAKNDPSHTLELSDGQLKFENVIADPTEFGSGDIATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAV0</accession>
    <name>I4YAV0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_19348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958738.1">
        <property type="nucleotide sequence ID" value="XM_006958676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAV0"/>
    <dbReference type="FunCoup" id="I4YAV0">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAV0"/>
    <dbReference type="GeneID" id="18470796"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19348"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032229_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAV0"/>
    <dbReference type="OMA" id="VEVQGIW"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="492" mass="56290" checksum="F2CA42B4CB6E16E8" modified="2012-09-05" version="1">MDDNIDWPVIYQRIRTSFQDVLAEPIVNKLRKEQFNRASLYQLLKIAEHRNDDPTSLDYLHKWVKSESYDIIPPPKRGPGRPPKSAQLENDEEAVDIPYKHVWKTGDPVPLQNSHKPAEKVGGGQALYTTFPARIKQGITTLMQPVNNILNQQATQAMANSRRKGFVNYAERDPDEFEEEYDSDDDSGSRRRSSRRQTEGGSTGPSTPMPGGIRRGDQFSYVGSYLGDIPPGASIVSEFLDKDRMFKLQYASERELEGNAERTFLPVPIRIEIDHENWRLRDTFIWNANETVLRPATFAEGLCSDLKIPIRPYADQIANLMQQQIEEHQAVIEVDVRTKQVEEVDGQPEDQDIAMNLETDLRVILNLDIQFANFHLTDKVEWDLCSPMPPEVFAETLCLDLGLSGEAKAAIAHVIHEELIRHKKEAIESGLMGASTGQRSDLDHPLFNGKGPRKLEGVWRDWHEADEYIPRLEYYTAQDIEKRELEREKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY5</accession>
    <name>I4YAY5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958804.1">
        <property type="nucleotide sequence ID" value="XM_006958742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY5"/>
    <dbReference type="FunCoup" id="I4YAY5">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAY5"/>
    <dbReference type="GeneID" id="18474043"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60591"/>
    <dbReference type="eggNOG" id="KOG4228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002713_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAY5"/>
    <dbReference type="OMA" id="QFIVCYE"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="186"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="487"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="700"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="913" mass="101983" checksum="4160D707E6281384" modified="2012-09-05" version="1">MSEDFQRALAERFGPNHTSVVTQPTLDLEKPDPFSPPVFNRSQTQASPMKSNRTSLTPQFQNLGKSNYVSPNRGDQALYTGSPSKDNDLNEFEKAIGSSDKLKRRTSLSRDAHTAGLTDKGPAFKKASPSPSPAQLGRPPPFNLKAPPMPRQATFSAPSTSQGTVDIRHAELHKLIEAIRQDPEIVKKEILVIDLRSYGSYCQTRVPGAVSVCLPSTLLRRPVFTLDKIINMISDPSDKAKLEGYERAKTIVAYDNDTSYVGEGISGNSAALLGVFKKFRDAGATASLEYIQGGFVAYSRAEGAPIEDTPKSTGNGPSDGKTENTFVQPRHLPITAFQGISTTTNKSSPRHGQINTSKFAANPFFDSVRQNRELANGMSQERIPMNISDDVKTNSYKLPQFLKRIVDMSEKDASDELAHQFYRLEVSEQKRMMEVFEWLSNNSQTLDNKGNQSASLGSKERDNTFVHGKERKIDRYSIGAGVELGHKNRYRNIYPFEHTRVKLKSPEIDGNDYVNASHVLPGIGYYGNDGLAPTPLYANPAPPAAAGKSDISNKTRNARKDLMHHTKRYIATQGPMESTLNDFWQVCWEQDVNIIIMLTKQREGGLDKCCRYWSDRKVGDIEISLIKMEGDEGDEKVKGPSKNSYVGEDSSTETASKEKFETSFVRRDLRLRNLKLNQEKTISQFQYLGWPDFDIPSQPDALLPLISTVNKLYDWNRGPIVVHCSAGVGRTGSYVALDTMLDLLREERRKPKSGDSESDEMQVDTTMRSDMTETDPGMRKDTKDSVTMDEHDDVNMEVERQTTSKDIGQKDDFPFGPPSPPENLRRKLSSMSSQASGISDGEDVGQKLKWSNLEGKREEHNNCQIVEGLHEPVCDVIEDLREQRMSMVSTLRQYVYVHSAVIAGVMNEIENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB15</accession>
    <name>I4YB15_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958830.1">
        <property type="nucleotide sequence ID" value="XM_006958768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB15"/>
    <dbReference type="STRING" id="671144.I4YB15"/>
    <dbReference type="GeneID" id="18474051"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60607"/>
    <dbReference type="eggNOG" id="KOG3382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110455_2_1_1"/>
    <dbReference type="InParanoid" id="I4YB15"/>
    <dbReference type="OMA" id="WHGWIHH"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="17550" checksum="0C2479EF891F94E0" modified="2012-09-05" version="1">MSGQSLYRHLRNWYRVGLRDGWAQLNEWVDVKAGRLAGTDKFGNRYYENLEEEMPEVPWRQRWVRYAQEAPLENASQVPSEWHAWLHHTRLNAPHEDEVVKKITAQTQHWRPAETHVENLTGTRGAFTTYNTTAPKLYPWQPKVAQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB19</accession>
    <name>I4YB19_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958834.1">
        <property type="nucleotide sequence ID" value="XM_006958772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB19"/>
    <dbReference type="GeneID" id="18471577"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32881"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484141_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB19"/>
    <dbReference type="OMA" id="QDANIRS"/>
    <dbReference type="OrthoDB" id="3365407at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="55931" checksum="6F3E3A3A015732C4" modified="2012-09-05" version="1">MSSTATGSNTNTASSSPTMSSSESSSNTGSSSASSSPTSSNSSSSSSSPTSSSSSSSSSSSSSTPTSSSSSSSSSSPTSSSSSNTSSSSSSDTSSSTSSSSSSSTSSSETSVSSSSSPTQSDTSTGSSASSTSSSRTSDTSSPTSTSSSTSSSSSTSTSSSSTSETSTSSSTSSTDTTTSSSTDSSSTSSSSSSTDSSASSSTPILSSTTDSNGSVSTLTVSMSPVPGESNDNGGSDNGATIGGAVGGAVGGAIALALLALAIFFIRRHKKKQLEPNMDDAIFSPDRGNEESAAGSSDQPTPFYGGSSNMSQRPGGPILPMSRDQAEEATSHNHSAFESFDSNSGGPFIVPAAAMGQSSQYSNVTSNNTAANSKFREAGLNPLSENGMRNNAGIGAAGGAFARRVPPPSSNSHYSHTSGGSDVAYGGIDSNASGSNVGAGAGAGAAGLKSRQPQYAVTNQDEIMQHTDGGPLSNEYNAHQQSELPPTYASLGDRSAGGNAKQRPSDDTFHDAAQDHVETMKPHSRLDSDASYPGLRDLTQNDDGRIANHQRLVSQETFPNPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB32</accession>
    <name>I4YB32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_38960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958847.1">
        <property type="nucleotide sequence ID" value="XM_006958785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB32"/>
    <dbReference type="FunCoup" id="I4YB32">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB32"/>
    <dbReference type="GeneID" id="18472088"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38960"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB32"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="12">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="372" mass="41926" checksum="C7045AB25BD84797" modified="2012-09-05" version="1" fragment="single">MTTVSKSNYKIHRSTDFPSLRNDLILQAAAGKKTVRAPTWIMRQAGRYLPEFRKLRESHSFFEICQTPELACEITMQPILRYEGLLDASIIFSDILVVPQAMGLEVQMLPAQGPHFPAPLDTPDDIKRLHEHVDIDKELGYVFEAISLTRKTLDGRVPLIGFAGAPWTLFAYMVEGGGSKTFSKAKKWLFDYPEASLDVLNRTTDVIVKYLVGQVRAGAQLLQVFDSWASELSHYHYEQFSLPFLRKISKEVRQECEEQGLESVPLIVFAKGVTHTVLPLLEDSGYNVIGLDWTTSPLNLSENVNAVQGNFDPNILYANDQAIDEQVKVVVEEFKKRKTPGWISNLGHGITPGVKPESLRVFLEAVQKYTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD5</accession>
    <name>I4YBD5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958630.1">
        <property type="nucleotide sequence ID" value="XM_006958568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD5"/>
    <dbReference type="GeneID" id="18473989"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60501"/>
    <dbReference type="HOGENOM" id="CLU_1636732_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBD5"/>
    <dbReference type="OMA" id="EITIAHA"/>
    <dbReference type="OrthoDB" id="3365394at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="162" mass="17886" checksum="D6115EC0F4729464" modified="2012-09-05" version="1">MDEITIADAFSNRLSIDVERSLIHQDILTPPTSSTSTNFSVNSRTSDILQRMRASRVIPPQKPAPRMPLPPVPSHPYANPSSNYASSLSSSQASLDRPSHKLGAPSTSSAQSLVLLPNFDEWSVKSSNMSTHDGRESRQSTSKLSKRKSKAFSLKIRNFFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBI1</accession>
    <name>I4YBI1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative succinate:fumarate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_18986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958580.1">
        <property type="nucleotide sequence ID" value="XM_006958518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBI1"/>
    <dbReference type="STRING" id="671144.I4YBI1"/>
    <dbReference type="GeneID" id="18470789"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18986"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="InParanoid" id="I4YBI1"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="318" mass="34488" checksum="8482FF3B5ABADB6B" modified="2012-09-05" version="1">MTKPAKEKVPLSTHLIAGGVAGAAEALVCHPLDTIKVRMQLSKSRQAKGLKPLGFYQTGKYIIGRESVFGLYKGLGAVLSGIVPKMAIRFASFEQYKLWLGSHEGTLSPGKVFIAGLGAGTTEAVAVVTPMEVVKIRLQSQQHSMMDPLDVPKYRNAAHALYTIVKDEGISTLYRGVSLTALRQATNQGANFTAYQQLKAVSYSYQPQYNGTELPSWQTVILGLISGAAGPLTNAPIDTIKTRIQKAQKVPGETAISRLMGVATDMWKQEGVASFYKGIAPRILRVAPGQAVVFSVFEKVKPLVERMKGEYLYEPSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBW0</accession>
    <name>I4YBW0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_60440</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958482.1">
        <property type="nucleotide sequence ID" value="XM_006958420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBW0"/>
    <dbReference type="FunCoup" id="I4YBW0">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBW0"/>
    <dbReference type="GeneID" id="18473946"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60440"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="InParanoid" id="I4YBW0"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="200"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="737"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1002"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM21452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1157" mass="126929" checksum="60A5DAF495B712A4" modified="2012-09-05" version="1">MLMRRSIRTFSSLNRPNCIHPTSLARRAFSSTSKSAAVAQSSVLGGDGGEINSPSELARKISAAVLPKIDKPNVKRVLVVGSGGLSIGQAGEFDYSGSQAIKALRESGIEVLLVNPNIATIQTSHELAHQIYFLPVTPDYVAAILEKERPDGIFLTFGGQSALNVGVALDKMGLFERLGVKVLGTPIRTLEVSEDRDLFVQALNEIDIPAAQSTAVSTVPAALEAAEKIGYPVILRSAFSLGGLGSGFANNEDELRDLSAKSLSLSPQVLIEKSLKGWKEVEYEVVRDAADNVIICCNMENFDPLGVHTGDSIVVAPSQTLTDAEYHMLRSAAAKIVRHVGVVGECNVQYALDPHSKQYMVIEMNARLSRSSALASKATGYPLAYTAAKIGLGHTLPELPNAVTKSTTACFEPSLDYIVTKIPKWDLAKFQHVQRDTGSSMKSVGEVMAIGRTFEESLQKAVRQVDPSFQGFEAYWQPEDLDAQLIQPNDRRLFAIAHAMLNKGYTVDKLHDLTKIDRWYLYKLDNIVQLHKQLSSISGLDAVDRELLYQSKRAGFADTQIATLTKSSEGEVRKMRKDLGITPFVKRIDTLAAEFPAHTNYLYTTYNAQSHDLEFNENGTMVLGSGVYRIGSSVEFDWCAVTCARAVRGMDKKTIMINYNPETVSTDFDEADRLYFEELGWERVMDIYELEQAEGVIISVGGQLPQNIALRLKQSGVNVLGTAPEDIDMAEDRHKFSSVLDSINVDQPAWVEAATLEDAKAFASKVGYPVLIRPSYVLSGAAMNVVYDESTLEHNLSAAANVSPDHPVVVTQFIDSAQEIDVDAVAHNGELLVHAVSEHVENAGVHSGDATLVLPPFSLPDAEMPRYKEIAQKVAKAFRISGPFNMQIIRKSGENGEEPQLKVIECNLRASRSFPFVSKVLGRNFIDIATAAIVGKNVPEPVDLMAEKRDYVAIKVPQFSWTRLAGADPFLGVEMASTGEVASFGKDIHEAYWASLASTNGFRIPKAGKGVLVGGDINKPELKSVSEKLTKLGFKIYCSNPSVEAHLNESGLSPTKRIFFPTKDKRKLREVFDDHEIQFVVNLAKSRGKDTVDEDYVARRNCVDFGLPLFNNARLAQLFVEALEKKMPVGGLDGYREGNIPSEVKSWKEFVPEEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBW1</accession>
    <name>I4YBW1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_51469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958483.1">
        <property type="nucleotide sequence ID" value="XM_006958421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBW1"/>
    <dbReference type="FunCoup" id="I4YBW1">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBW1"/>
    <dbReference type="GeneID" id="18472558"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51469"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011791_3_0_1"/>
    <dbReference type="InParanoid" id="I4YBW1"/>
    <dbReference type="OMA" id="ENICALH"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="5">
        <location>
            <begin position="334"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="446" mass="48477" checksum="E070F32DE9F12E3E" modified="2012-09-05" version="1">MSYKLSRELIGHTQDVKCVHFINSNTLLSGARDNSAILWRNVDNNWAVAARVHTHDNYVNSVGYLADNDAPAYTLLGHSGNVCSIDTSSDGLIATGSWDTTARIWKDGVELSCLSGHTQAVWSVKFTPDNKHVITASADKNIAIWDVKSGAAVKTIQGAHKDAIRALTILPNGIGFASASNDLQIKLWTFDGENIMNLDGHTEFIYSLATLPTGQIVSAGEDRSVRIWQDGECVQTIIHPTTSVWAVATSENGDIASASSDGTIRIWSQDPARFADQDALKAYENVIAGSTISSRSSNGINPKDVKSPEVLQQAGQRDGQVILVKDAQIVSAYSWSVGESQWKKIGEVVDAAGGVDPSKRVKHSDGKEYDYVFDVDIEDGKPPLKLPYNVSENPYIAAQRFLEKNMLPLTYLDETVKFIESNTSGVELGQGSSEFVDPYTGECNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC11</accession>
    <name>I4YC11_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ICE2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958532.1">
        <property type="nucleotide sequence ID" value="XM_006958470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC11"/>
    <dbReference type="FunCoup" id="I4YC11">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC11"/>
    <dbReference type="GeneID" id="18473965"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60468"/>
    <dbReference type="eggNOG" id="ENOG502QRTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027878_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC11"/>
    <dbReference type="OMA" id="TTPDRSW"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43103" checksum="177D84853DD24102" modified="2012-09-05" version="1">MTIMTGLNNIKRILSFIQVLFYLPLTLNISNKSTFLTLSLLLSIYYSLLCSLRLFSSKLLRYPSILLGALQPFIIPVLLLYSFHLNSSSTIPSVVIDTFESLLHASSPTFSLLEGASALLCIQATGQFSRLYIRRKGEGSTLILLILSAVIYVLSGIWLIHSYPAAASTPFSATMIGAALVATLAISSLALISKRATVIETALMFSYIAYSIWLCADAIQGASGWIDFQWSFDNQGWVIQSFENALQFLKNALGDSLEFIGYAFTTLPPTLLVSLIFRTGVLYLATKIIPLIRSSSSSITHSFERAADACNDDDLNDDEPSAFIMAILVSFSRLILILVYSHLLLLDQGAQLWWRWANVAWTLSLWVVEIILSSSYSDDDVIVKSWKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC15</accession>
    <name>I4YC15_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958536.1">
        <property type="nucleotide sequence ID" value="XM_006958474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC15"/>
    <dbReference type="FunCoup" id="I4YC15">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC15"/>
    <dbReference type="GeneID" id="18473967"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60470"/>
    <dbReference type="eggNOG" id="KOG4453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_1_0_1"/>
    <dbReference type="InParanoid" id="I4YC15"/>
    <dbReference type="OMA" id="TKHEVPR"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27209" checksum="9B05A60DF34CD9D2" modified="2012-09-05" version="1">MESDEQKRLDNKKRTLGVGELELPRKLFHSSIGPIAIGIYISQVSRTIVLRLLTILLLVILVIDLFRLRSTVVGRGRFASLYESVVGRLMRESERQKLNSTIWYLLGAVISVASFKRDIAITSICILAFADTSASTVGRLLGRYTYTLPSPPFGQKKSLAGFTAAFLTGAFTSWLIWGSTFGQATIAEAGKLSTDTLSWTTESKLRFPLLMIVVGIISAVTESLDVHGLDDNLTIPVISGILMTLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ5</accession>
    <name>I4YCJ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_64307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958374.1">
        <property type="nucleotide sequence ID" value="XM_006958312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ5"/>
    <dbReference type="GeneID" id="18474915"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64307"/>
    <dbReference type="HOGENOM" id="CLU_1205592_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCJ5"/>
    <dbReference type="OMA" id="FMEDEFD"/>
    <dbReference type="OrthoDB" id="10508561at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24141" checksum="4546C1CF117504F6" modified="2012-09-05" version="1">MDARALLRAKKAERAPVRSNKRQAESSLDVPQVEKKRKSEVAEIPTDFFDNSASNENDDHEEQQEKNDDNTVRQTETEPANVDNQVTHQKSIEEELMAFDNEISQLDSQPAPSYNPSIFANATISAEPVLNPSATEEATPEGTNTLTGRGQKVISEEQRQVDEEEKLKRIQAYENEDYAQRLEEEARAQEEADARVTALKQRMEEIKARRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP0</accession>
    <name>I4YCP0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_63965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958043.1">
        <property type="nucleotide sequence ID" value="XM_006957981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP0"/>
    <dbReference type="STRING" id="671144.I4YCP0"/>
    <dbReference type="GeneID" id="18474883"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63965"/>
    <dbReference type="eggNOG" id="KOG3476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133934_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCP0"/>
    <dbReference type="OMA" id="MPCDKCE"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="13872" checksum="5C911EFBCD9EC4D5" modified="2012-09-05" version="1">MQVMRTILTVVRVNDILIVDYQRLSATINMVCAKCEKKQTKVAAPDPFRNKSLGASASTSKQTDERNDLGKNKLLSKNRYLPYAAKTGGSKCKVCKQTTARPDAKYCQNCAYKRGKCSVCGVKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV7</accession>
    <name>I4YCV7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase GET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958103.1">
        <property type="nucleotide sequence ID" value="XM_006958041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV7"/>
    <dbReference type="FunCoup" id="I4YCV7">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCV7"/>
    <dbReference type="GeneID" id="18471475"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32375"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCV7"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="331" mass="36136" checksum="A302E491D3695690" modified="2012-09-05" version="1" fragment="single">MTDELEPTLENVVNNKTLKWIFCGGKGGVGKTTTSCSLAIQLAKTRESVLLISTDPAHNLSDAFGQKFSKEATKVNGFENLSAMEIDPSAALQEMVENDQAGDSGVGNFVQDLAFAIPGVDEAMGFAEIMKYVNSQQYSCIVFDTAPTGHTLRFLSFPTVLSKALEKISSLSGRFGGLINNFSGMMGGGAPAQEDIFAKLESMRTTIDQVNTQFKNADLTTFVCVCIAEFLSIYETERLIQELSTYGIDTSNIVINNLLMLPQDDQGKSVSSCDRCLARDATQKKYLAEADDLYGEDFHIVKIPLLLNEPRGAPSLLKFGEMLVDKTRNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD08</accession>
    <name>I4YD08_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative intermediate compartment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958152.1">
        <property type="nucleotide sequence ID" value="XM_006958090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD08"/>
    <dbReference type="STRING" id="671144.I4YD08"/>
    <dbReference type="GeneID" id="18473853"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60271"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="I4YD08"/>
    <dbReference type="OMA" id="ANGVMQY"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="206" mass="23271" checksum="C3269327B2A74C4B" modified="2012-09-05" version="1">MDEDIGWKYILKYCIIGDSGVGKSCILVRFTDNNFYNTTTATLGVEFGSRIITLNNKEKVKVQCWDTAGSERFKSITRSYFRGAAGCLLVYSLSSRDSFNNLESWLNDIRKYADDNLTVLLVANKADIPYSDREVSIEEGENWARERELDFIKVSAKTGDRVDEAFDRSARIILEKLNKGAFQPKANKTSEAVLKIENSKNISSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD11</accession>
    <name>I4YD11_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958155.1">
        <property type="nucleotide sequence ID" value="XM_006958093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD11"/>
    <dbReference type="STRING" id="671144.I4YD11"/>
    <dbReference type="GeneID" id="18473855"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60273"/>
    <dbReference type="HOGENOM" id="CLU_900800_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD11"/>
    <dbReference type="OMA" id="YESLTAC"/>
    <dbReference type="OrthoDB" id="10394977at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="34235" checksum="891F98DBC427C620" modified="2012-09-05" version="1">MSRLSYSQLEYELNQGRSDDQLKRIQSKYGIAAKRQLMNRVAKLNTAQESGKSGAELDARRTVFKLSHDQLAQRIKEGAKWADIGKEAGVRSTYAQAVWASIQNRYPGIKYAHGKGRGRNGHSVTDEDKYTVYMFRTGEISRAQAYERLTACGRTRGGAKQILNKHSHTDINNLTEVTASSRPRALSNTSIASTSSSVGTRYEPQQHQQPLMMTPPPSSYGSSRSSSVEAEPTTPVSLPISSLLQPSGAGVDEEPPKLRKTISQSVPMGYWQGPTSQPLPMLVPIQSRAYDESYSYRLPPISLERAQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD24</accession>
    <name>I4YD24_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_32423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958167.1">
        <property type="nucleotide sequence ID" value="XM_006958105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD24"/>
    <dbReference type="FunCoup" id="I4YD24">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD24"/>
    <dbReference type="GeneID" id="18471485"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32423"/>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="InParanoid" id="I4YD24"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="21719" checksum="ED9E6ECA0EA96C72" modified="2012-09-05" version="1">MASKIQRSANAARVQPDEIELAVGQALVDLGNNVPDLKAELAPLTISSAREVDVKGGKKAIVVFVPVPQLKAFHKVQQRLTRELEKKFSDRHVVFVAQRRILPKPTRNTKQTQQRPRSRTLTAVHSAILDDIVFPSEIVGKRLRQSADGSKLIKCYLDPKDSHILEHKLTSFESIYKRLAGKDVVFEFPAHADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB0</accession>
    <name>I4YDB0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957764.1">
        <property type="nucleotide sequence ID" value="XM_006957702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB0"/>
    <dbReference type="FunCoup" id="I4YDB0">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDB0"/>
    <dbReference type="GeneID" id="18473744"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60105"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="InParanoid" id="I4YDB0"/>
    <dbReference type="OMA" id="SAYPRWG"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="27068" checksum="ABDF969A5C80A95D" modified="2012-09-05" version="1">MPTVLVTGSSRGIGLEIVRDLLSKNNNVISISRTITDELKELESDKLLIVKGDLVDRSVSKVAVDEGIKKYGVLDSIILNHGVINPIGKVSDINPEDVLNIINTNFISLYHTIQLALPHLRDSKGNILLVSSGAATAGYSAWTAYSASKAAMNSLARTLANEEKDITTIAIEPGVVDTPMQQSIRNNGNNAMLSEDYKFIMNLYSEKKMLTPDQPAKVFSNLSAIKLSGQHSGAFLSWDSNEFEDFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDC9</accession>
    <name>I4YDC9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">WALSEDRAFT_57094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957781.1">
        <property type="nucleotide sequence ID" value="XM_006957719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDC9"/>
    <dbReference type="STRING" id="671144.I4YDC9"/>
    <dbReference type="GeneID" id="18472878"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57094"/>
    <dbReference type="eggNOG" id="ENOG502QT3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010017_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDC9"/>
    <dbReference type="OMA" id="NIMAFKF"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="597" mass="66408" checksum="D0DF044E60F28E44" modified="2012-09-05" version="1">MAFKFQWPDFNAAFLADARTTLDNALNKGPKPPIIADRIIVEDLNMGTIPPELEILEIGELSVDKFRGIFRMNYAGDAHIVLRTKVQANPLTTKGSKPGLLGGRSILAAHQPLVVPMHLRLSALRLRAIIVLVVSKQKGITLVFKNDPLENLDVNSTFDSIAVIQKFIQQQIEGQLREMFREDLPGIIHRLSQQYFDSREKAKKSSSSAPRRSAMSANGELESYQTLYGSKSDRPTRSMNIPRRSNRLSTQSQPHSPTSSTFPDLEFYDPTYGLRPHLKEAQENLGETAFGKVWERSRGFLQPSDKNTVDDLDDIDLFDPPINTDAFEAEDDDAVSESLRRLHLDEDEEQEELNSIDDVTGSTAWRTRSSRSLRTPASDATSYISSRTATARPVSTTSYKHTQITEDTRSSISNSRSNSFADTSILDDSTAPTSILEEDKVAPKPYNLSTSPTIQKSIRYTDTGKMTIMAPINENIKELGNLSQVNFTLSPNTRVFERSTVRSFPHTKQRNSKGIQKARRKRVHKLGGKKEGKKEEKEATSSSTSNTASTPQEATTPVVQTPAHALDKTKNIKLALWAREASLQAPKPPPSVIASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDJ2</accession>
    <name>I4YDJ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_17896</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957751.1">
        <property type="nucleotide sequence ID" value="XM_006957689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDJ2"/>
    <dbReference type="FunCoup" id="I4YDJ2">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDJ2"/>
    <dbReference type="GeneID" id="18470744"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17896"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023309_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDJ2"/>
    <dbReference type="OMA" id="NLRQPYT"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="358" mass="40981" checksum="746EA0022A6C76BD" modified="2012-09-05" version="1">MILAGLGAVAGAVHLARDWEDDAERKEAEERIRKAGEGAIDNSWWSRLISRLRGYTDVFDKPAWSELLPPMMPPPNDRKYTLLVDLEGLLVSSSWDRQHGWRTAKRPGAEYFLGYLSQFYEIVLFTTQPNYTAMPVIEKLDPFGAYVPYRLYRESTRYKDGKTVKDLSYLNRDLSKVIVLDTNRENVYAQPDNGLILKPWKGEKGNKDLIAHIPFLECIALFNVSDVRPVLKKYGDTNIPVEWAKVEENMRQKHIENWKNQGAQPKRSGWGFGASSMRPPASPVSISTDAGKGQPPLSYLDLKRKEAQAIYQLEQKYWNDNKEEFSKIIQEDQKRQTEELKGQLWGMVGVNSGAPQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDJ6</accession>
    <name>I4YDJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">DNA topoisomerase</fullName>
            <ecNumber evidence="3 12">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_51054</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 12"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957843.1">
        <property type="nucleotide sequence ID" value="XM_006957781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDJ6"/>
    <dbReference type="FunCoup" id="I4YDJ6">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDJ6"/>
    <dbReference type="GeneID" id="18472542"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51054"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDJ6"/>
    <dbReference type="OMA" id="MELAMGD"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="17">
        <location>
            <begin position="169"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="649"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="573"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="719"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="797" mass="89450" checksum="72C87E32EE1B9003" modified="2012-09-05" version="1">MAIKYLCVAEKPSISKSITQILSSGSYNSRNTSSKFIKNYDFNYKMTGYNGRQVSFTVTAVAGHLTASDFGKDYRKWHSCDPLQLFDGRVEVSTAGNMSAIEQNLKNEARSSSHLMIWTDCDREGEHIGAEIMSICRKANPRIEVSRAKFSAIIPNQIHNAARHPAELDMKQVRAVEARIELDLRIGAAFTRLMTMNLSKQIAELDVHTGPCQFPTLGFVVDQYQRIKDFISEAFWYIFVSIIHRDDDGKDSNVVFHWQRDRLFDPDLSFILYEQCAINPSARVTKIAEKLYQKGFLSYPRTETDQYDPSFDFHSLIDKQANDGVWGSYARSLTDSGFDKPREGKKNDKAHPPIHPTAHASGLTGNDKRVYEYITRRFLASCSRDAKGKNTNAEVEIAGEIFKASGSVLLEKNYLNVFPYDKWSSHTIPNFTVGQVFTPSVCELREGKTTPPNLLTEADLVSLMDKHGIGTDATIAEHIHKIIDREYVMEHKQGNTKYLVPSTLGVALVEGYNKMNLEKSVSKPQLRRENEERMNRIGEGLVEKTDVLIESIDQYKDIYIRSARQFQVLVESGNNDEDDYDDGFGGGGNGGGGNDSDDHDGGPPTTRRRGRPPGSKNKTTRNSTANSNYQMTVFEPSKTNTPKEGQVRCKCDLSAKRFVTQQGANKGRAFWKCPNTSKSAQCNFWSWEDSLNVGNANTHQNQDDDYNLINDDELIADDDASCKNPQRAPPRESSSGATRATSRKATSNSSTSTKNGDTCYKCNKKGHWASNCPNPAKAPAKRKTYTRKSTQKRQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDN1</accession>
    <name>I4YDN1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_45205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957877.1">
        <property type="nucleotide sequence ID" value="XM_006957815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDN1"/>
    <dbReference type="FunCoup" id="I4YDN1">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDN1"/>
    <dbReference type="GeneID" id="18472358"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45205"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="InParanoid" id="I4YDN1"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="183" mass="21122" checksum="C87485E23BD0481F" modified="2012-09-05" version="1">MSKRNLPNILITGTPGTGKTTLSQSILESLNRASDQQNQFKHISIGDLVKQKDLHNGYNNEWQCYDVDDDKILDELESTIESGGNILDWHCSEIFPENWLDLVIVLRCDHQVLYQRLEDRGYKSEKIQENNDAEIFGECLHEALEAFPNPGQVVELQSEEIENLESNLERFTLWLDNWKSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE06</accession>
    <name>I4YE06_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_68650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957993.1">
        <property type="nucleotide sequence ID" value="XM_006957931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE06"/>
    <dbReference type="FunCoup" id="I4YE06">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE06"/>
    <dbReference type="GeneID" id="18475447"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68650"/>
    <dbReference type="eggNOG" id="KOG0178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_1_2_1"/>
    <dbReference type="InParanoid" id="I4YE06"/>
    <dbReference type="OMA" id="RDFSCEY"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="664"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="943" mass="104559" checksum="6B551CD6EFB1A6C3" modified="2012-09-05" version="1">MARRYDSRTTIFSPEGRLYQIEYAMEAISHAGTCIGILAQDGVVLAAEKRVTSKLLDKAEASNEKIFNLNSNILAGVAGITADANSLVNYARMQAQKYLYTYDDNIPVEQLTQRLCDLKQGYTQYGGLRPFGVSLLYAGHDMHHGFQLYHSDPSGNYSGWKATCVGANNGTAQSLLKQDYRDGVSLWSAAPNQQDETEGSKCGAVELACKILGKTLDATTIDSDKVEFAILKLDPKTGEPKGHILKAPEIDKLLTKKEWTFHEETLVISSDSGSDNDDEIGNTGSIHTLNASSDSFVVPKLDNAIQFILFVQACVECSSTRSRIEITNILTNYLRIVRKNDPDALLPSLWLFSSQLGPPYEPNELGVGKLVLNGALKDVAALSPTRLKQLHNRLGDIGDVAFEATRNVISVVKPKPLTVSQVYGTFKDIATQHGPRSVTAKTNLVKKLLVSAKAEQARWLMRALVQNLRIGAVRTTLSHALARAFAVGTPIDLPSAEKIVRRVYARHPNYTTLVKALLDSGLNELEMKVPVQVGTPVQPMLGAITRSLADVQTRLRGQPFTSEAKLDGQRCQLHASLVDSKQKNGWTSPLVRDNTYLYVRLFSRRLEDMTEKYPDAAMSLYEIFKNEPSLSSIVLDAEIAAIDDMDNIRSFQELSNRSRKAVDVDEVKIRVAVFGFDCMLFNGETLLDKPFRERRSIMRTHVPPFKPSSITYAPWDHMPSIDDTGLVEISAFFEKCMTMKAEGIMVKLLDYYEPTDTDDAVKTRRKALPATYEPDKRAESWLKVKKDYLEDVGDSIDLVPIGAWHGMGRKNQFWSPILLGVYDDDEGAVTAVCKCMSGFSDAFYKAIGERYAEGSSNVSKHAFPGVIIGDTSPDVYFQPSEVWECRGADITQSPVYPAAKGRISDKGLSIRFPRFIRVREDKDVEQANTAADLASMYEKQQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE26</accession>
    <name>I4YE26_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_57249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958013.1">
        <property type="nucleotide sequence ID" value="XM_006957951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE26"/>
    <dbReference type="STRING" id="671144.I4YE26"/>
    <dbReference type="GeneID" id="18472893"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57249"/>
    <dbReference type="eggNOG" id="ENOG502S4MW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621434_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE26"/>
    <dbReference type="OMA" id="RYGSSCM"/>
    <dbReference type="OrthoDB" id="3366918at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="441" mass="48778" checksum="8CBA8AAE4EB7B278" modified="2012-09-05" version="1">MLHEKVASNNITELQQAPLEEIELVDENGMTALALAAKLSNIQAIDILLAKNGNPYSAIPHASDPQVAQKLHAAIQPPPFYPPPIQHFYPYPPPMDMQVYYQEDQQQQQFGAQNGTLPPPDVARNIPCRFFPGCRYGSECIFMHPQPTMYLPPPQVPPFEAIPQAHAPFYQLPPQMVPPPFATPIPPTPIPTEQAQQNEEKIEDENQKPDLQQQPQQQQQQQQPPPPFMHPIIPQDPYMIPLARPPPMMMPNNNFRNNRNVSRGPTITKRGKDGQLPPCYFFPMGKCRNQDTCAFPHLLPDGTDVRDPALRGTAPINSHKRQSSRSNNFENKKFNTPAQANHQASFTGNKVPPSMPRAQAQAAASRTQSPAQRVPTQEDFPSLSSNVSSSSENGNYSINYSTPQTTPSSSLVLNNITNSVTKELPQQSFAAAASSTLAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE38</accession>
    <name>I4YE38_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_44564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957495.1">
        <property type="nucleotide sequence ID" value="XM_006957433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE38"/>
    <dbReference type="FunCoup" id="I4YE38">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE38"/>
    <dbReference type="GeneID" id="18472334"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44564"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="InParanoid" id="I4YE38"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="34811" checksum="38CBB0F95C1530DF" modified="2012-09-05" version="1">MVLEASFVLIDNSEYMRNGDILPNRFQAQVDGVGLLAQAKMNMNPENTVGLMTIAGSSPEVLVTSTADDAKIIASMHDVKISGELDFIHGLQVAQLALKHRQNKVQRQRIVAFIGSPISEDSKELEKLGKKLKKNNVAVDLVVFGEIDENQEKLEKFIHTLGGTDNNRILIVPPENRTILSDYLINSPIVRGTVDPEESGPSNPAPSGFEFGVDPSLDPELAMALRMSMEEEQARQTAGDQGAEQSTQMEDIKEEKEKDEKGTQAEKDVEMSTADQPQSKQEEDTTIVDADDADDEEAEIQKAIAMSMQNDNQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE63</accession>
    <name>I4YE63_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_44603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957519.1">
        <property type="nucleotide sequence ID" value="XM_006957457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE63"/>
    <dbReference type="FunCoup" id="I4YE63">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE63"/>
    <dbReference type="GeneID" id="18472337"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44603"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="InParanoid" id="I4YE63"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="433"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="784" mass="90015" checksum="098B6AC71FB8EDAD" modified="2012-09-05" version="1">MSSWSSKPVNKNEQIAVPPANDLKSTWAFLEEGIDHIMTRLRDGMTYSKYMSLYTTSYNYCTSSRMHIGTEPLGTGRTAGANLMGSDLYSNLIKYLTSHLKIVKENSDSLYDLQLLQYYAAEWDRFTTAASYVDRLFSYLNKHWVKREKDEGRKNVYNVYTLALVQWRSSFFLPIQDQHSKLVSALLKQIERQRNGETVETTLIKKVVESLVSLGLDEGDSSKQNLDIYQLHFESPFIHATEIYYKAESEAFVAANSVTDYLKKCEERLAEEEARVDVYLHASSRKRLISACENALVSDHMEIMKDEFVNLLEYDKEDDLNRIYTLLARVDALEFLRKKFEEHVKRTGLAAIEKVYGNAVEAKKDAPVKKEKEAEKGDLEPKAYVDALLEVHKKCSLTVKNAFKSESGFSAALDKACREIVNRNAATGTSTTKSPELIAKHADSLLKKGNKQTEEAELEDALDQVMTLFKYIEDKDVFQKFYTKMLAKRLVSGTSASDDGESSMIGKLKDACGFEYTNKLQRMFTDISISKELTNSFNERMSQTHDASELDVDFDIKVLATNFWPMNPQNTPFNIPSELQATFERFNQYYNSQHSGRKLMWLYNTSKNELKTTHLNQPYIFLCSTFQLSILVQYNEHDSLRYDELKAATNLNDALLKQTLATLVKSKVLLQDEDTYDLNFNFKSKKIRVQLNQPIKADVKQESNDVLKTVDEDRKFEIQAAVVRIMKARKTLKYQNLIQEVITIVQSRFSPKVSDIKKAIEALLEKDYLERNLDAGRDVFNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEE8</accession>
    <name>I4YEE8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_37113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957595.1">
        <property type="nucleotide sequence ID" value="XM_006957533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEE8"/>
    <dbReference type="FunCoup" id="I4YEE8">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEE8"/>
    <dbReference type="GeneID" id="18471996"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37113"/>
    <dbReference type="eggNOG" id="KOG1272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEE8"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="553" mass="62253" checksum="5086A82C96CFEFAD" modified="2012-09-05" version="1">MNSQPKKQNKAIKKDNQLSSISNSIKPKKNHDKIEIDDELPDHLTKAAVPNGKLRNKLIKQWKHKLASQRAIDDYKNYLLPQDSGTIELENDLERTYRLRQHDIKEAIGISTAKKAFSLNVDRGLTSLAYTPDGRNLSFTNQVGKVASFDPTLGRLNCEINLNELCTDITYLHNSSMMAVAQKKYVYIYDNQGIELHKLPDHIEARRLEFLPHHFLLASSGNTGWLKYQDTSTGMMVSQHRTKLGPTSAMAQNPSNANISLGHQNGTVTFWTPSTPYTHVKLQAHLGQVKALSHDRHGKYIASAGLDGTVKLWDMRMWKELSSFKARNQIKDIRFSDKDMLAVGWGNHVYVYDDILKYSSNGESPSPYLTHHFPGVGVNKLAFCPYEDVLSVGHSAGLTNLIIPGSGEANYDSLEADPFEGKGARREREVRQLLDKIQPDLITFNDDILGSIHLKTDNTNPNAKTPNLRPDDDGQFHDDMGRSKLKKKMRGRNSSTKKYLSRKRKNVIEPTQLALKAKLAKEKANKDKEIALKSGNLKQSSPSALDRFTKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF1</accession>
    <name>I4YEF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957598.1">
        <property type="nucleotide sequence ID" value="XM_006957536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF1"/>
    <dbReference type="FunCoup" id="I4YEF1">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEF1"/>
    <dbReference type="GeneID" id="18471414"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32041"/>
    <dbReference type="eggNOG" id="KOG3323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_0_4_1"/>
    <dbReference type="InParanoid" id="I4YEF1"/>
    <dbReference type="OMA" id="VFGADMK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="146" mass="16556" checksum="1520C2B5431E662F" modified="2012-09-05" version="1">MKVVIQKVSKASVSVNQKIVNSIENGLCLLVGLGVDDNEDDLKWTVNKVLGLRLFDNWTKSVRDVDGEILSISQFTLQSTLKGTKPDFHKAMKTEEARKMYNNFLTSLKTSYFDNRIKDGIFAEMMDVNINNQGPITILIDSRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEI6</accession>
    <name>I4YEI6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_32062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957628.1">
        <property type="nucleotide sequence ID" value="XM_006957566.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YEI6">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEI6"/>
    <dbReference type="GeneID" id="18471417"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32062"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000129_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEI6"/>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="1906"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="2706"/>
            <end position="3038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2476"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2511"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="3070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3070" mass="346459" checksum="9AB93C8DF486FD3E" modified="2012-09-05" version="1" fragment="single">MSAISPPNDYLFAGCTGNIMLKSIKLAHKSRNPYNYLILLKILSQAIGGGRYEKFYIEVQALLQSYIDGLTNLLDEADKVNKELIIQLFLILPMRFQVVLPFLHSLTRPLCMALESKNDEIVEQALRLVEICVETLNPVYVDPILAPQIRQIQTGIYRLLKPVPANHKLAHTAVRVLGKLGGRNRKAINIPARVSPRVVDQSASIPVEFHDKEGVKQLNLVPLVDLATKAIQVASDDYAHAVSTDRKVQKGGDEEKAIGILKHSIAPLILNGLNGVLQEDLYQKVLDSLFDAALVPSLTDLSLDFVKELASFILTREMKEGIYLSDGIPALSRIACFTLDAVCSSLKLTVSHDDTLSRDLVTAIIRDVVTETVNEDSQIDVKTYMLNQIASRFASLCHDQLWRCKLAGLAGMNILTGEEVGLGEKWVAGHQIEFYRAAIYILKDMPHELPNDVDEVTAFVKKLIDICNGPNGPVVSENAMDYMEASRPSTPATNIANPFNALNRHMDSPSTSSTPGGTDPQRSQFNHLISILIADLTSPKDIVRKTTQKTLTQLSERTQIPIHELLAPGKGVLSSAIYHKPLRALPVPMQTARIEAVTYCLQLRPPLPPMESQEGENQPESDKGTANEASAATSASVNNKHPGVLEINEDLTRFVHEVLGISDAEDVAIIGQRPPHIVQLALAELRVACVKLLTAATATSDIFRTANQARMRIISVYFKSLYARNSELHGVAHEGIKQVLVQSGKVPKELLQTALKPILINLSDTRRINIAGLDGLARLLELLTNYFKVEIGTKLLEHFKSLLDEKDLKAAPSPKINLPPNATIQQQQQATAMAAQASVQPPLSGDLADLHDVKIMVAIANVFRLLPSAANIYLEQFSNLIVQTEQRFRRVLGSPWTTPLAQYLDRFPNEANEFFFARMDSSEHFNTYRAALISSHAVNLRADVLAKPERIVNSFFSPEALTKTGFALHGLKIVRALMDLSPNLLAGEQKGNVLWEAIWSLWSQYVNSDKPIVDIASRTKEIETLLEILLIHLSNHPDPAMLIYMAEVFTLKLPINLVGLTRFYIKDVALSSSSELKQVILSHFVNKIPDESLSQSHKMFIVRHIVNPIAVVAKYRPNETVIDEAFIGEMHTKVWSPFQKDDEYTGVDNGFLIELLNFSATLVDVVPDLLGEFKKDVIKFGWNSQRHVDTSVKHSGNILMCRFLKAFDSPSNLARNVYVGLLKGVQPETKNMAREALDILTPVLPQRVPERAPAPVSHLPQWAIRIRRVLVEEQQSAAQLSTIYSLIIRHSELFYPIRELFVPHMLNSITRMGIIPSAANDTRQLSIDVLELILQWEQKRMSMSEEDKESQSGDKRRASEGLDDQPAAKRTRSSTATSTPQQGTPQPAPKPYILHHNLRGHAINYLVRFASISNESISAPNSLSARAIELLKGYQSLDSHNDISAKLAYFLKVLTQSELKEESATVHCNSAEVLCALALPEQDAYFLSNLAGMARIIERCYASNINRLHLTLESLVKRIFSILPSVTEDDDSQQGREIKAFSSMIENIINDGLSGSRNPHNALCLLRAWTDVHPDKFDMFIPAHMRLLQIITREHCSTDKKPSYLIDPKLIPFTLELACRRVSQLGEARRIFLTCIVMLIERTTSIDVCSSILDMIKNWITEKKEAFPTAREKAGLLIKMMSIENRQYDIKGVTNDTPSKEASKNLFNDYLELILSIYKDSFYARSELTVRLENAFLLGCRATNGELRSRFIEVFHESMYLSIASRLQYVLGVQNWDSLSNVYWIHQALDLVLGSIKSNNIIVSSEFGENAFVQKLKSFTIEGLIQPVRQLQYIDDESAHEIWVTIFGSAWSSLNRKEQGEITRHMIGLLAQEYHLKQVDARPNIIQSILEGVLIASPSIALPPHLVKYLGKTFGAWHTSILLLEQLTEVGRESESVNELARDALAEIYADLAEEDMFYGLWRRRSGYQETNAALSYEQLGLWSEAQVLHENAQIKARSGNVPFNEPEYAIWEDHWVLCSQKLQQWDLLTDLAKNESNADLLFECAWRTSDWSQDREVIEGAFKNLADIATPRRRIFEAFMSLVRAQDTNEPANDFNKITTEAIQLSLKKWHSLPDIPGPANIPLLHTFQQCVELWDASNIFQTFPATNETNVEQRSSEIKNIVHQWRDRMPNLWDDINIWSDLVAWRSHVFQAINKVYLPIINNLQANPNAPNTGQNSFGYRGYHEMAWTINQFAHVARKHQLQDVCISLLTKIYTLPNIEIQEAFLKLREQARCLYPTTDGLGAGLEVINNTNLHFFAPSQKSEFFTLKGMFTAKLGLHDDATQSFAHAVQTDLNLPRAWAEWGRYNDQQFKAHPENMSLAANAISCYLQASGLYRNHKSRKLLARVLWLLSLDDVNMTISKAFEAYKGDFQVWYWVTLIPQLLLSLSHREARHARLILIQIAKKYPQALFFHLRTTREEYTVLRRQAQAVAAAKAERGEPTSGVHLAPPSQGMLTPHLGSPAPPHAKPQQPSQVPQQASQPGQSQVPLYKNPWDWVDEVLSILKTAYPLLTLSLETMVDQISARFKSTPEEDGYRFVNALLSDAIMNYSMRDKNSSLELAQTTRQALNKFVEQAVIGKEKVFANEPGLGSELQLPQYVRKLLVWRKKFEKVLGSRPRFQSLEYSRRHLIEFHLNKYDQIEIPGQYNKHEDEDRSTFLKVARIAPKFEFYKSHGVSWKRLTFVAVNGTRHPFMVQMPPTRHVRREERNQQISRIFNAVIDRRKECRRRNIYFNAPLSVPLSTSLRLVQSDPSTVSLEDIANKHCEELGVDNITPILNYIEKLKAVSKPEDSETTTLSLKMEIIEEIANKYVPEDVLTKYMNRCANSPSEFWMLRKQMTNQIATLIFMTYSFCIAHRQPHRIMITPSTGAVHTTDVIPGSINQECQLSNPESVPFRLTPNLQHYLTSIGIEGLLVSSIVSLGRCLTEPQYDLENQLNLFVREDVSSWFTNQRRQNPSDSEVRKCIQQNVDGIVARATVLGCKYEREQFNQNQGNANNQKVIPACQSVLELIAKATNPIELAKMDPQWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEN0</accession>
    <name>I4YEN0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957667.1">
        <property type="nucleotide sequence ID" value="XM_006957605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEN0"/>
    <dbReference type="STRING" id="671144.I4YEN0"/>
    <dbReference type="GeneID" id="18475384"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68380"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_6_1"/>
    <dbReference type="InParanoid" id="I4YEN0"/>
    <dbReference type="OMA" id="TYWVISF"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="526" mass="56236" checksum="099B4A95C52F02B5" modified="2012-09-05" version="1">MTREDEGEARSPLMRGRGASIGNEFAINPMPLLSSTEEEADIATFSPSRTIGIVEGISLVVGMIVGSGIFSSPGNIVSLTGSAGASLLIWIVGGSLAWMGASCFAELGTALPVSGGPQAYLSYAYGPLTSFTFTFTSISIIKPSGAALIAIIFGEYVARFFYLLGSNEVLSSNDIPSWISRLVACFGVLLVSLINIISTRLLTRTQTVLMVIKIAAVLLVVVLGVIAAVRSPDQIFSPSKALEGTKVSPSSIALALYSSLWAFDGWDQSNYVAGEMKNVERNLPIVIHTSIPLTIIIFLLANIAYLIAIPVNLVAKSNTIALDLGDVVLGNVGSGLLTCLVAVSTLGALTSGSFTTSRLISSAASSNSEAGFLPQALGAFNKRTQTPVNAIVLQLVLTCVYIIIGGGFQSLVNFYSVAIWYFYLLCALSVIVLRMKEPDLHRPYKTWIAIPMIFSSVTIFLLCMPVFAAPLEAAAAFGFIALSVPVYFISNYIKFRKVDIVNHIPAIIRNKFKKTYKPLSSEMQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP3</accession>
    <name>I4YEP3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_16947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957466.1">
        <property type="nucleotide sequence ID" value="XM_006957404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP3"/>
    <dbReference type="STRING" id="671144.I4YEP3"/>
    <dbReference type="GeneID" id="18470711"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16947"/>
    <dbReference type="HOGENOM" id="CLU_2869377_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEP3"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="64" mass="7263" checksum="3F90B33682AB275F" modified="2012-09-05" version="1">MTQRPKSILKNTQGDNSQKEDHGLTWDEENIAVTESQKDSTMKVTEPKTPYVKYNAESEPHGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YES0</accession>
    <name>I4YES0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957703.1">
        <property type="nucleotide sequence ID" value="XM_006957641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YES0"/>
    <dbReference type="FunCoup" id="I4YES0">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YES0"/>
    <dbReference type="GeneID" id="18473730"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60084"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="InParanoid" id="I4YES0"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="39251" checksum="278313C86873EB71" modified="2012-09-05" version="1">MPPSISRVYADANEKHSRSWWDYDNLTVSWGEQTSYEIVRRVGRGKYSEVFEGININNDEKCVIKVLKPVKKKKIKREIKILQNLAGGPNVIALLDVVRDPNSKTPSIISEYINNTDFKLLYPKLTDFDIRFYINELLKALDFCHSKGIMHRDVKPHNVMIDHQKRRLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNYDQLVKIAKVLGTDDLYKYLDKYEIELDSHYDDILGRYARKPWNKFINAENQHWVSAEAIDFLDHLLRYDHQDRLTAQEAMAHPYFEPVRNSDIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFC2</accession>
    <name>I4YFC2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_36690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957329.1">
        <property type="nucleotide sequence ID" value="XM_006957267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFC2"/>
    <dbReference type="FunCoup" id="I4YFC2">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFC2"/>
    <dbReference type="GeneID" id="18471973"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36690"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFC2"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000938">
        <property type="entry name" value="Probable periodic tryptophan protein PWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="9">
        <location>
            <begin position="750"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="864" mass="96189" checksum="25DF1F2C378B50C3" modified="2012-09-05" version="1">MKSNFTFSNLCGTVYRQGNVVFTQDGNSVLSPVGNRVSSFDLVNNQSFTYPCENRKNIARIALSPDGRILVTVDDDGRALLINAKRRTVLHHHNFKNPVNDIKFSPSGKFLAVTHGNHVQVWKTPSFLIREFAPMELYRTYTGHFDSITSITWSQCSRYFVTCSHDMTARLFTLDPLPGFRPKTLSGHKDRVIDAYFSKDSKSIYTVSRDGAVFVWTAKESEEDSDSDEDSDSSSSSSDSSMDEDRQIADTRWGVSARHYFNMPGTRVVCSTFHQNSSLLIVGFNTGVFGLWELPSFTNLHTLSISQEKVTSVDINPSGEWLAFGARKLGQLLVWEWQSESYVLKQQGHFSDMNAVAYAPDGQLVATGGDDGKVKLWNLSSGFCTVTFSDHTSAISQVEFAKQGRILFSASLDGTVRAYDLIRYRNFKTFTSPTPTQFSSMTVDDSGEVLAAGSIDSFEIFLWSVQTGKLMDVMSGHQGPVSGLSFGPGGAQLASSSWDRTIRVWDIFRRARTVDPYSLNSDALTVTFRPDGKELAASTLDGQIQFWSLEDDKQTGVIEGRKDISGGRKQDDRITAANNSSGKCFNSLCYTADGNYILAGGNSKYVLLYDVKEGVSLKKFQISENLSLDGTQEFLDNRMQLDDGSNIPTGPKGDESDLEDRLDVSLPGAQGGDLSKRKYRPEIRTKCVKVSPTGRTWATASTDGLIVYSLDESVLFDPFDLDIDLTPESVAKTVSKGDYLVALVMAFRLNDEKLVEMVYTSTPPAEIKLIVKQLPLVYVDKLVMFIGKHMERSVHLEFDLIWVSSLLSYHGRTLRSRQIEFATPLRSVQKGLVDWQKGITALCEENEFTMEYLLSQPLEIDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE6</accession>
    <name>I4YFE6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_36734</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957352.1">
        <property type="nucleotide sequence ID" value="XM_006957290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE6"/>
    <dbReference type="FunCoup" id="I4YFE6">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFE6"/>
    <dbReference type="GeneID" id="18471976"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36734"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_30_0_1"/>
    <dbReference type="InParanoid" id="I4YFE6"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="67"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="247"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="415"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM22688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="499" mass="56276" checksum="B298D84F4881A5DA" modified="2012-09-05" version="1">MASTSQTQESEWKNQIRAPPKDLRPQTEDVTNTKGGEWEDFGLRRELLMGIFEAGFEKPSPIQEEAIPSAIEGRDILARAKNGTGKTASFVIPSLEKINVQKPKIQALLLVPTRELALQTSQVCKTLGKHLGIQVMVTTGGTTLRDDIMRLADPVHILVGTPGRILDLASKGVANLEECPTFVMDEADKLLSPEFTPVMEQLLGHLPSSRQVMLFSATFPLIVKDFKEKHMRNPHEINLMDELTLRGITQYYAFVEERQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKVTELGYSCFFSHAKMLQSHRNRVFHDFRSGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNSETYLHRIGRSGRYGHLGLAINLITYEDRFSLYKIEQELGTEIQPIPSQIDRSLYVAPNASNEDGQIQQSQQQNQQQKGLPTLPPTQQVMNAYAQPPPQPTFNQNQQQNNHHQYQQRSHRGGYNNNGYYGNYRGRGGPPRGGVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFH8</accession>
    <name>I4YFH8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_36779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957381.1">
        <property type="nucleotide sequence ID" value="XM_006957319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFH8"/>
    <dbReference type="FunCoup" id="I4YFH8">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="GeneID" id="18471978"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36779"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFH8"/>
    <dbReference type="OMA" id="PWVHPIY"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="82"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="405" mass="45240" checksum="987E87706D0747C5" modified="2012-09-05" version="1">MSATKTIQETAKHVSAVPATFNPFYSHDPTTADDENYEYNFLKPSFPDVKWAPLELQDVTDRGFSADKSKKNLLSAATKVDNIEPSIGTELSGINIYELTDAQKDELALLAAERTVVILRDQPIDIHKQLDAARYYGPLHKHATTSVPKQEGLEEVHVIYSDGAKRPDPAAFTKTELFHSDVTYELQPPSTTILQVLTAPTEGGSTIWSSGYAAYDSYSNTFQQYLETLYASHSAHEQYNGSLQAGTNPRREPITTLHPVVRVHPVTGWKSIFVQPGFTRSLFTKKGDNVVPIPKHESDHILNLLYRQIADQVDSQVKVRWGKGDIVVWDNRVSAHAATFNTWPQTRLGVRTTPHGEKPRSVEEHNALNLPSGLARSRQEQVWKEQGLQDTNVPVNLNKAKGYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ4</accession>
    <name>I4YFZ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_67773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956935.1">
        <property type="nucleotide sequence ID" value="XM_006956873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ4"/>
    <dbReference type="STRING" id="671144.I4YFZ4"/>
    <dbReference type="GeneID" id="18475296"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67773"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488534_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFZ4"/>
    <dbReference type="OMA" id="CVINPEY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697949" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="359"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="558" mass="62153" checksum="A7E15BE337C08A56" modified="2012-09-05" version="1">MKVVGILYLLIAILVLVYAYIPANAVDHDYSSDTDKSSHLQLYGDVRSFNDDSISLQMSGEDTNGTTSGFIVHFSEQNATTQSYTQSPWLAFISCDSNSTDSTDDYDIFSFAADRGARAVLLYTTTKERCEINPVFLQTYNRVIDVFATSSRDSARLIDNQFDVNSTYYWYNSQIINDTAKAIEDNPSMRVPYLLATLSAYNATQPPSQPGPVDEGSQDNQDQPSNTSLAMIVLYVIIAVVTILFMIVILSGAFRAARNPQRYGERPARREVLDTLSGQTVIVEDRGQTRAGGIARAILETFPLVNFNNELRTSNKADNSDEARDIEMGESHHGDDSGSAHQSPKEPIKEVDGEGPRSCSICYEDFEQGEQLRILPCNAKHCFHAKCVDPWLLDVQGACPLCRQDFRAQTVQSCSNRPTTAETSTSNDSSNANITDPRDFPPLTTGHLANRRQASLLSLRTMIRSPFRRQRQDAEANTQEHLEVQPEENLNDSSQNAAVESQNVDASVTARTNENTNENNTNDISQDDSNENSRSHSRNFFSNLLKRNKNRNDHSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG32</accession>
    <name>I4YG32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_31605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956970.1">
        <property type="nucleotide sequence ID" value="XM_006956908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG32"/>
    <dbReference type="FunCoup" id="I4YG32">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG32"/>
    <dbReference type="GeneID" id="18471333"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31605"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032156_0_1_1"/>
    <dbReference type="InParanoid" id="I4YG32"/>
    <dbReference type="OMA" id="GATCNQN"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="358" mass="40280" checksum="6006254844397861" modified="2012-09-05" version="1">MTALAGDPGDQAIKPGQDRNNFYWLTEEEPHRSRCRAIMKAHPDVKKLFGPDPRTALVVLSVVAIQLVTATSIINFGWHPLSWKFLLTAYVIGGTANQNLFLAIHEITHNLVFKSRTANKALAMAANLPVGIPFAGTFKVYHHEHHRYLGEDGVDTDLPTNFELLFLRNVLGKLFFATFQILFYAIRPGLVNPKPPTPFVLLNAAVQVAFNAIMYKAYGGGIFAYSVMSTFFAGSLHPCAAHFIAEHYMFDGSGQETYSYYGFLNWLCYNVGYHNEHHDFPAVAWLNLPKVRDLAPEFYNHLQYHQSWPLVTFRFIFEREVGLFSRAKRDSHTTKPNVSAARESAILPGEGRSLEGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGA1</accession>
    <name>I4YGA1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_36287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGA1"/>
    <dbReference type="STRING" id="671144.I4YGA1"/>
    <dbReference type="GeneID" id="18471954"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36287"/>
    <dbReference type="eggNOG" id="ENOG502QUA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020178_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGA1"/>
    <dbReference type="OMA" id="RDYNAVN"/>
    <dbReference type="OrthoDB" id="3355860at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="57"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="478" mass="53133" checksum="1719EA7A6E391A86" modified="2012-09-05" version="1">MTRLSHKESSSDKDQMVDREDNATERASQSALYSKGFWSPDLKPLRATYFKILSGSVVLTIIAIWSCLQVYWASIAHESGRLFQVNSVFVNRDITNGVNGTLGDTLRTTIFQSLNEKHHLGWTEEPSEKVPTAESIEEALVEDEWAWVFVVAEQDATQNLIIARENGDSSYDPMSSVSIYYAEARNEQAAGIVLPTTQKLVQQATIQAGTQMLAAYMSQQGGNVTAMEALTNAPQTAATPFATTINNFRPFDQPVARAITLVGLIYLTILSFICTMAHSAARPLLEKHLTLRSYIGMRLLVPLFLYTILSLFFAMLNLPWDVHFNAHFSNTAKGFFCTYALLLCGMAALGMCFETLAHPLLISPTGLATEAIITVIGPQFMAYALIALIISNVSVAALPVDLQVWFFRYYPAMVYYHINRGIRCIIFNTKNELGFNFGVCLAWVVFSIGTISAFTALYRRLDIKKAQKESETQGENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH8</accession>
    <name>I4YGH8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957103.1">
        <property type="nucleotide sequence ID" value="XM_006957041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH8"/>
    <dbReference type="GeneID" id="18473541"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59760"/>
    <dbReference type="HOGENOM" id="CLU_837304_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGH8"/>
    <dbReference type="OMA" id="CEEWADW"/>
    <dbReference type="OrthoDB" id="10548236at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="36212" checksum="08A4A33B5EA564B2" modified="2012-09-05" version="1">MFDESAFDPDDIGSAAPSPSMSAVSAVPSLFYGTSSPSSSLCPSPTTYAPTNNNSALASPGIPCISLPPTSSSSKAGSDEIKFTRKPSAQNAPVPTTFTTSTPYQSRRRSYPVIRQSQFGATSAKPANQPAEQININGMVHPHSQASAVDSLRKHTNASSSLMSHSTSQTPISNFLNGWFGGSPTQSMTSTNRARSQSHSHSQSVFSDGNIFYPEQDERTNRWFNDDTEGERRGRSATRSNSRDALRRSPRASRSSRKANASRSKSSVRILSPLKQEQSDDTINLEDEVSNKLMISTHHRPSDNDNFDLEATPKLEKKQVVSLIIIMFSWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGI0</accession>
    <name>I4YGI0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 60S ribosomal protein RPL37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_36399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957105.1">
        <property type="nucleotide sequence ID" value="XM_006957043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGI0"/>
    <dbReference type="FunCoup" id="I4YGI0">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGI0"/>
    <dbReference type="GeneID" id="18471960"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36399"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150908_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGI0"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="11039" checksum="BB28D4C87FF07836" modified="2012-09-05" version="1">MTKGTTSMGKRQSVKSHGLCRRCNKRSWHYQKQSCASCGFPLAKTRTAFSSFHFNWGAKAKRRTTTGTGRMRSLKYVSRRFKNGFREGTVAKKAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM0</accession>
    <name>I4YGM0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957145.1">
        <property type="nucleotide sequence ID" value="XM_006957083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM0"/>
    <dbReference type="FunCoup" id="I4YGM0">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGM0"/>
    <dbReference type="GeneID" id="18474811"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63135"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="InParanoid" id="I4YGM0"/>
    <dbReference type="OMA" id="EDQWPEM"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="162" mass="18294" checksum="D2C1B30966E4343A" modified="2012-09-05" version="1">MSSSNSDKEAHRSNTHPRIVCGAVPINYLTNQILLISSRKHKGNWVLPKGGYELSDVRLETAASREAFEEAGVIGQVRNLVLSIDDKRPIKTLTDNDPFIPRARYHFFEISVDELSTQWPESNERDRCWCSFGEALNRVSWRDEQRAALLACSLNNNSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH18</accession>
    <name>I4YH18_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_53580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956650.1">
        <property type="nucleotide sequence ID" value="XM_006956588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH18"/>
    <dbReference type="FunCoup" id="I4YH18">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH18"/>
    <dbReference type="GeneID" id="18472620"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53580"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="InParanoid" id="I4YH18"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="204" mass="23059" checksum="6622DF997D265061" modified="2012-09-05" version="1">MAEASTSQVVPQKDIVYCGICQFPVEYCEFSNSFKRCKQWLEEELPEVYISLYSENALKDKMGSLSVEAEKKLEQDVAKNEAKAEKKALKEIEQKKSSKITIIREERTKRKVTTHIQNLDAFSVELKPAAKLFAQKFATGASVTKNPQGKDEIVVQGDVTDEVEDMLHARQKVLSVLPEKVKVIKEDKKKKKANVEGAEDGHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHA9</accession>
    <name>I4YHA9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956735.1">
        <property type="nucleotide sequence ID" value="XM_006956673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHA9"/>
    <dbReference type="STRING" id="671144.I4YHA9"/>
    <dbReference type="GeneID" id="18473430"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59573"/>
    <dbReference type="eggNOG" id="KOG1039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096595_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHA9"/>
    <dbReference type="OMA" id="MYYNWRS"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="252" mass="28406" checksum="0A9469D9254B11B1" modified="2012-09-05" version="1">MSSLSSKENGSVTSHVPCKFYKKDQCRAGDDCPFSHSTQAKNKSNIQPCTWYIKGSCRFGHRCALSHVMPGQPQSMDKRNKKEALQLQKDLIKESLNKVDDLLRIPQSTSLNALPTTSLKPESSPVAKPETHQLSQSLSSFQRPSLYYNWRSFSYVDNDDINLDKNETLDDLENGEEFLPSSLDELLTPLERRRKHSSRTSSISSAFTLSPAINTTQQLPTPAMNNMENSTLTLKPHTHEDDATQFDLDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHD9</accession>
    <name>I4YHD9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956762.1">
        <property type="nucleotide sequence ID" value="XM_006956700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHD9"/>
    <dbReference type="STRING" id="671144.I4YHD9"/>
    <dbReference type="GeneID" id="18475276"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67642"/>
    <dbReference type="eggNOG" id="ENOG502S9U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660906_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHD9"/>
    <dbReference type="OMA" id="AHTEQNI"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="438" mass="49080" checksum="0ACC5D8474273401" modified="2012-09-05" version="1">MTSINPLDEFEKFSYNAGEDDLKSDFQLIDDPLWCIRDNKEVNSKSIKSDTPTNLGDLDKSPLEQSNEFQPQHHLTNLFSKNWNELQTVSPQQVSLDWTPAQTTSDFPKTTKNTSSPATAALANFNNNDNYDNYDNFKPLFQPTDITQQKPDLRAFNSSSGSSDEEVNLPSIQPTEPRPAATIAPEAPKAPIKGSKTTAPSKPSTSKDKNVNTNTNTNANANALKGQPTTTHKRAHAETHSHSHHRTPSQPKEITPPDDNDHYSPSTSPNYQSSEEEDDDNYTSQPTRQRRRRGPAKQTSKSESVGKIHPPNDHMPYPYEVTSQGLTRCTYTSPIQPFNRCRTLFHRPYDLARHMETIHSRDEAQLVKKGEITMDQITIPGLAKALEEAEKDPKKAEKLIAVQEWKCDGKGGCGGTFSRKDALIRHRRLRGHGVPKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG4</accession>
    <name>I4YHG4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956783.1">
        <property type="nucleotide sequence ID" value="XM_006956721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHG4"/>
    <dbReference type="FunCoup" id="I4YHG4">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHG4"/>
    <dbReference type="GeneID" id="18473444"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59594"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_5_1"/>
    <dbReference type="InParanoid" id="I4YHG4"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="44"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="588" mass="65686" checksum="678FC07A8C1BC245" modified="2012-09-05" version="1">MSSFGKENNSEIDVNGRNMRSHYKPRVSYYYSKGVGDYHYGEKHPMKPHRLALTNSLVLGYGMHKYMEIYEPQRATREEICEFHDEDYIDFLSRLSSPPTPTMINLMKQFNMTDDCPAFPNLYDFCQQYAGASLLGARHITSQRSDIAINWTGGLHHAHKAEASGFCYVNDIVLAILELLRFHPRVLYIDIDIHHGDGVQEAFYNSNRVMTVSFHKYTGDFFPGTGALSETGQGAGKHFSLNVPLQDGIDDYSYVALFKNVMSSTIESYRPSAILLQCGADSLGCDRLGAFNLSIKAHGECVQYIKSWGIPLMVVGGGGYTIRNVSRCWAYETSVLLNMGVNDTLPQTSYDEYFAPDYVLHPPIVTKVENQNSKASLERLVINCREHLRYLNGAPSVQMQEIPPDIAKSMDTAELSLDERNELNYGQTNGSEVRHPDSHTSNNEYYDDEVDQDALNVEQVELSRLAEEVEEDNEIRENGEAMEGVERVEAAQPLTQTDDADIPQGYETDSVPQTSENVSQAAEEGAIPQPMQAEFVPQPIEPPPAPQVVGTTPASVDNEVPQTVQVKTEVMWPENTSTAVKSEPDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI41</accession>
    <name>I4YI41_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF572-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_15014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956146.1">
        <property type="nucleotide sequence ID" value="XM_006956084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI41"/>
    <dbReference type="FunCoup" id="I4YI41">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI41"/>
    <dbReference type="GeneID" id="18470648"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15014"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_1_1_1"/>
    <dbReference type="InParanoid" id="I4YI41"/>
    <dbReference type="OMA" id="CNNCENI"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="209" mass="24364" checksum="276FE0F24503B0AB" modified="2012-09-05" version="1" fragment="single">QGVRYNAEKRKIGNYYSTPIYAFRCKCHLCSHWFEIQTDPKNTRYIVSEGAKQKAEWQPEEGETITMETDPDKKPAVDPFAAVEKGTNQVEAQKKVVPRLSQIGDANDATWSDPYAMNQKLRAKHRVERRQEHASNRANLELKDRYALPEDLQIIDDQRDNSESSAFKQIQRRKATKKPGDLKSTLISNTRKKMDPFDRSSRRFKFREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI88</accession>
    <name>I4YI88_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956346.1">
        <property type="nucleotide sequence ID" value="XM_006956284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI88"/>
    <dbReference type="GeneID" id="18474739"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62348"/>
    <dbReference type="eggNOG" id="ENOG502S284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415736_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI88"/>
    <dbReference type="OMA" id="ILGWATH"/>
    <dbReference type="OrthoDB" id="3353982at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="75934" checksum="3B9AF9860B8B8F7D" modified="2012-09-05" version="1">MGSLTKLPSELWSAILEQLDQRDQSSTSAALMIAFPKAPVDFKHVWMHIHLRNELQVKALNMKLMNDREMKLTLQSQSYLGQSLRHTAMLGDPYFLINVYESLKHVQLLSIFVGPAFAPEHLSEFFNKPRNNLRTLNIHFRPYLKRRSYYQFLKGAYFDSTLEQLALNWPINPNLTRLSFIQDNPPSLDHKESKERLPLHVEQSVDLIDHSTYLESYSGGPTSYFKKRILTDDLPKKFAHPIVFFNLSHCLTQFSTSPFASSIEHMRLIIPQRDVATSLAIKDSLPKVKSIDLSTTLIKVVGPDANLSNLLRKLRSLEYLILDQTDVLGTDVTYTNVVARDRARKSARAIGQMSATTGLVHAKSIEIAINEWVAEQRASFMQFDESIIERQQDERNEEIVQPRRRINTGRRAFQANFSIRTETGSDTRNLPRLSNAAKAYLENAPVNYLVLPELSQLKAITVGVSDQVKKCRREEWHKEFEKGWREGCNKVVETIEQIYKAWMKSIEDDCTADGSTTNKTITQKTKNKYKTYGKSNNQPRAQRGQVKKKVEIIKLEDTKDNETSKSTLPNNFKDHFKGMSICSDEKQMLELIERASDREYQVPVFCTKAKCEHPRNTGDNEGESEEELEEEVVESDKEEEIIECPSNCAHRVIWDIWKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI92</accession>
    <name>I4YI92_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_31174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956350.1">
        <property type="nucleotide sequence ID" value="XM_006956288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI92"/>
    <dbReference type="FunCoup" id="I4YI92">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI92"/>
    <dbReference type="GeneID" id="18471259"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31174"/>
    <dbReference type="eggNOG" id="ENOG502QS34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="InParanoid" id="I4YI92"/>
    <dbReference type="OMA" id="VFPMTWK"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="390" mass="44418" checksum="220F8DECFF7FB4F1" modified="2012-09-05" version="1">MNVTLLNRDSNEFGRVITGVDIEKLSTDDFNLINDLLHKYSVLLFKNVDLSPENQDKLTRLFDPAAKGYGHGNNKTGSSKKSILHPDLKTIPRIPTVQVIGNGNVYNHEGLQEAKLKHPHHKTFHKTKVSEEDEKKGITRFYRWHIDAALYDLDPPKVTTLYAIKVPQGPFQTLRYDDGSGEELKVPLGSTAFVSGKKMFEILPENYKSLAVRTEVVYAAHPYVWMSKAKSRSNGLGLETEGLELSYDELPDVEESKIKTYPLLWKNKVTDDLHFQVHPSAIAELKIKPITSENKRKTDSLYPDGAHITELGKVREIIYNMQRPAIKPEYVYAHEWNERDLIIFQNRQVLHSVVGAFEEDQVRVFHQCNLAASENEPIVGPSVDDVEQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIH4</accession>
    <name>I4YIH4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIPSNAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_35409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956429.1">
        <property type="nucleotide sequence ID" value="XM_006956367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIH4"/>
    <dbReference type="STRING" id="671144.I4YIH4"/>
    <dbReference type="GeneID" id="18471912"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35409"/>
    <dbReference type="eggNOG" id="KOG2883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053393_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIH4"/>
    <dbReference type="OMA" id="REKSWSV"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="179"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="32036" checksum="16ED944D8FFD0708" modified="2012-09-05" version="1">MITARTLRQTINKAKPYTARLYSSGNTDKSQGYLNSFLHGSHTAQKEGAEAEKIGHSRSVGRNKYIHEIQKHHVKPAKIDDYKAAVQDYYLSLIGDKENHLKLTGSWEVMYGEQDTFIHILEYEGFKGLDDTLALVRKTNANALFNERVRPLLNHRTSELSQEFAFFPSSPPHSAGGIFELRRYQLKPGSLLQWESFWRKGLEARRQFVTPVGAWFSQVGQLHNVTHMWQYPDFESRKRTREQAWTVDGWAYTVSETVKLCNTMETSILEPLPFSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIH5</accession>
    <name>I4YIH5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956430.1">
        <property type="nucleotide sequence ID" value="XM_006956368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIH5"/>
    <dbReference type="STRING" id="671144.I4YIH5"/>
    <dbReference type="GeneID" id="18473331"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59394"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="InParanoid" id="I4YIH5"/>
    <dbReference type="OMA" id="PMYRQFR"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="34621" checksum="3D8928E8377EF96A" modified="2012-09-05" version="1">MEIEHPYKSNYSDLSKGVQNKVVLITGAASGIGRSATIEYLKLGAKVAACDINLSRLQSLAEELSNPTDLLIAKVDVTEYDEQYNFFTAAVEKYGRIDVVCANAGINPSAEFMNPNLPANVKPDLKVVDVNLTSVLYTSHLAVRYFRENTVAKEGEKCLILTGSIASFHALPATGMPYSAGKAAILSLTQSLSLQGQIEGFRCNCINPWFADTNILNKSMRMILKGLPLASVDIVSQAFILATATDATDQAWVIDEHGLWTLPNPAIKSQVIEAFMNRFFIGMKIKRAIRNGSLQRYLAMSTVVIGVLAAGYRYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIN6</accession>
    <name>I4YIN6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955675.1">
        <property type="nucleotide sequence ID" value="XM_006955613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIN6"/>
    <dbReference type="STRING" id="671144.I4YIN6"/>
    <dbReference type="GeneID" id="18474666"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61664"/>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="InParanoid" id="I4YIN6"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="9923" checksum="037BA69986E421C5" modified="2012-09-05" version="1">MIPGAINLPADSLSLTLPSLLPSLNHGRGPRAAGWFAETLNEYLNTDEGLRDCVYALTGGIKAWKEKFGSCSLEDRGKRWDDKSWSTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIQ6</accession>
    <name>I4YIQ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_66751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955694.1">
        <property type="nucleotide sequence ID" value="XM_006955632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIQ6"/>
    <dbReference type="STRING" id="671144.I4YIQ6"/>
    <dbReference type="GeneID" id="18475142"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66751"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007550_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIQ6"/>
    <dbReference type="OMA" id="MRDKELH"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="121800" checksum="35C71216779941C5" modified="2012-09-05" version="1">MSNGQPTFDSFPDIFSTGNDNTQRDSDSKFSSRRDKDRRERDSKSRDIEKEKRRRDDRYRDRHPNRNRDKSRREDSSYYDDRYPSKSRKRYAESADIDEPSSSNRNVDFRPPKLTSDDKRFFYTSSFGDKSNLTLEGPELAVIPRYRRSGKGRVLGLPRDILINEKVQYRSRNIILPSEHHSRSLRAPKTRLPEQDKNVRRIVPSRSSLKTDEDFVPLVSQRKRAKQREAQQHGYLTLDVDYRSLEGPSKSNNADEDVNGSSDENSDEEESSKTRYNDTVKKRIEWDRHLKENPQDVEGWLDYVKFQKDIVINENIEVSSKNVRNVVLDLQYQVLEKAITYQPNNVDLIVKKLEIGASGLKDDIIREFQFAIRRYNGVYKIWRSYIDFVQCHASIISRGEIYPNEADRMCPFEISSRVYRDAFHALANQGSDNDLINLFTRYCSFLLGAGYTERVYSLYQAVLELNSRNISVDQLGKLWHDTNFKRVGNIVEDIDEEYRLEYPEYATLQLQEWEEYEMINDTVDNSFPVVCERNFSDDPFRNVLWEVDLLPFLIKLRGVDCKEKLLDSLLSIFSISMIPNGISTNDEQVRDLLLQGRTYCHENFELGYPSYFNQPQYINTIFPLHDTYQNFKDEHLEHLQRIADDLVLPQKQMLLYQNDNSKLKQILANNVDNWYLYDIYARLQYAKSKSESSRKVYRECLKSSSENEIDRVKLCYSWSLMEFMQGNLNVSLNILCDSSSSGVVNDLTQQQTTMNILKARRFWSSLDLSNFEAISCRALFEYLVSRSDEKAVTIFEEALNKLPASTYNHEVLLTELVCFIDSLERLHDMDRTIQLPSTSTIKWVYGNAKKTYPHNSLFRYLYFNTEAKFGGYRQLFDEGMEENEYAEVYIQMAKNTLKRSEANNVPYVNKVRRIFAVGIASQKAQHSVALWKSYYEFEFNIMKDYGSAEKVVMSSLRFCPWSKELHMFIFKVSKKTQNTNHLLQIINVMSEYGIRMRIDPSPYIRRAVEFELNNEERLKAENLVENSENSEEEMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX5</accession>
    <name>I4YIX5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955758.1">
        <property type="nucleotide sequence ID" value="XM_006955696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX5"/>
    <dbReference type="GeneID" id="18473121"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59007"/>
    <dbReference type="HOGENOM" id="CLU_921970_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIX5"/>
    <dbReference type="OMA" id="PFTIRIY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="302" mass="35813" checksum="56AB0DC44E394B1F" modified="2012-09-05" version="1">MKSFDYKPQTIKRIIHDTNGKIYEHRIMNAIWREETKSIDLYVVIRGVGGTSIARMFDRRYLAARETPWDSIVEKEFRSALVDGDLSGQEVELRAHRECLKQYERQKNIYEFVKQEHLYYFQEYETSITLIMSNAPGGHYQEYFNVKGILLQHVIEAKSLPRSLTLTSASHVRKTAVKVFNNLARSGILLQDYDLNELFVFLEFDLEFVFMDVDQLRFRSEFKDDDDWANNVIAWRRHFNKAVAAAVDDQLTEADLFLEPQFIFTDNLEGVFGGFTRETFMRFSRKNWEKCKEIWRHIVSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIZ9</accession>
    <name>I4YIZ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955780.1">
        <property type="nucleotide sequence ID" value="XM_006955718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIZ9"/>
    <dbReference type="FunCoup" id="I4YIZ9">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIZ9"/>
    <dbReference type="GeneID" id="18473131"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59021"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_837301_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIZ9"/>
    <dbReference type="OMA" id="RIEARHM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="148"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="38946" checksum="2800F02A40CAA9CF" modified="2012-09-05" version="1">MDDYLYKIEELKIKNNFKFNLQNNLLFNLEEYLVNLGSFKDNLVAIDSKFNDINNDLIKINDKLSQLKYSNKLFIDNLTSLYTKQSDLERQQSELQSFIDKFTLSDKESTSLLDNNHPIDDTFISSLTRLSIIRDDAQLLLNDKDNDIGLEILSMSSHHFEVALNKLLKWLKFEFTSKFNRFSIEIKPLHIQSLKKLAIRDDLYLEALQFLTLQRKNLLERCFLDALTEFENNQDIITDPIKYSTELLAWLHQHAADEKDFLCDLLDTDDVNEQLSNHLQPLANRIQLQLTHALNFTQRSQDLLQLISFYEQSLKNSINANCINNLFKKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ63</accession>
    <name>I4YJ63_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_30786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955839.1">
        <property type="nucleotide sequence ID" value="XM_006955777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ63"/>
    <dbReference type="GeneID" id="18471181"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30786"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="I4YJ63"/>
    <dbReference type="OMA" id="LPHNARG"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="519" mass="58964" checksum="8CA7D4F2E16E9DF8" modified="2012-09-05" version="1">MNIVDEKDLKQEYEEHEVAPDGVLRHGQTVDLETYSNDDEEFGGYENRKKMERKLLWKTDARFAIMIIIYILNYIDRNNVPAARHQGLEDDLELGYDNRYETVLSILYAGYIVMQVPSNGIVSLISRPSLYIGGAMALWGMISCLTGITQNYVGILLTRLFLGFVEAAFLPGAMFLLSKWYKKNELGVRMTLLYCGNLISNAFGNLIAAGIVNGMEGKLGHRAWRWLFYIEGALTIFVAVCAVFVLPDFPETERFLSPLERKLAIRRMAEDAGQVDTVMDKHEVLRGMKMALLDYRVWWLSLTLFGMVIGLSFNIYFPTLTEEMGFEGTQALLMCAPPWIFATIVAFPWSVSSDRFQERTFHILVSNLVSIVGFIIAIATQNKAARYFSLFLMTLGYCGFICVYAFTSSSFIRPTSRRSVAIAFVNAFSNIGNIAGSYIWDADKFGPSGYRQSYAICISCTGLSCFLILGFRYILVNLNKKIEKLEEEYPGMDPWDIPEKCDRKLDNALLVKRGFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA8</accession>
    <name>I4YJA8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_66915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955880.1">
        <property type="nucleotide sequence ID" value="XM_006955818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA8"/>
    <dbReference type="FunCoup" id="I4YJA8">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJA8"/>
    <dbReference type="GeneID" id="18475177"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66915"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_1"/>
    <dbReference type="InParanoid" id="I4YJA8"/>
    <dbReference type="OMA" id="ANDHDLK"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697758" evidence="6">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="389" mass="43023" checksum="9AFCF7E26B3540BF" modified="2012-09-05" version="1">MKLKFILTFAVAIGVALANKELFSLHKDLIIRPSITRNETLAVDFLSNYLEQNGWKVELQDVINPNIDSSIKRQNIFAYLNKPEDVKILLNSHTDVVPPYVEYKETVDDQGRELIYGRGANDAKGQIAAQVIAVEELRKKNPEIVKHVGVLYDPGEEGIFDGATFAQEILPKNLEYVIVGEPTELVQITGHKGNMGFEIRAKGLAAHSSSPHWGVNAIEKLSEAILKLESVTLPKDKLLGDTTMAVTKISGGTAMNKVPDEATAYVNVRTSVPSEETWKAIKGSGLESEWIDLVLVDDPHDPVILDTIENWRSSQTMPFGTDLFAWKHPTVKKILIGCGSVASAHKLDEHIYKQELLDGVDMYVELVEGLLTGKLKVAGGHTKHEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE2</accession>
    <name>I4YJE2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Diphthamide biosynthesis protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Diphtheria toxin resistance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_55936</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955910.1">
        <property type="nucleotide sequence ID" value="XM_006955848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJE2"/>
    <dbReference type="FunCoup" id="I4YJE2">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJE2"/>
    <dbReference type="GeneID" id="18472758"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55936"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJE2"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="557" mass="60539" checksum="A9CC8F096186DCFD" modified="2012-09-05" version="1">MATITNSGEDIISNSLDVTQLDIADDPSNSFEDSFEIPRTVDDILNGGFTRIGLQFPDELLHYSVRVFKSLERHLGSDKKLYILADTTYNACCVDEVAAQHVDADVVVHYGHACLEPTARLPVIYVFGKRTIDVDSCVDALSTSLRQKTARETIISTDVAYAWKAQTIADRLSQAVEDNMKVILHGLPPTVAYPAANSGAPAGVKPGEELLQDHEADGSPLGTDSTQEKPTCSDQKQSCGDTCTSCDCTVQQPLSLAQRAVSSEPKKITADESTIIIYIGPPSLKLTNIVLTNRPASIIAFDPTVNSTFEATGTENRLLQRRYAQVNKAKDCDVFGLAVGTLSTASYLPLVKALRAKLQKASKKVYTVAVGKLNPAKLGNFAEIQCWCVIACAENSIVNSKEFHVPVITPFELEMALDTDRIWTGEYVLDFSQLLDPSSKYSLEAHSEGGNDQDEPIFSASTGKFIKHRKFNKDNEMDVPIAEGVDALTLRTTENALQVMNNSAAGAYLQTERSWKGLEVREGQDEPSLLESGRAGVARGYTLPDTLAASESQSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE8</accession>
    <name>I4YJE8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955916.1">
        <property type="nucleotide sequence ID" value="XM_006955854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJE8"/>
    <dbReference type="GeneID" id="18474695"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61919"/>
    <dbReference type="HOGENOM" id="CLU_037893_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJE8"/>
    <dbReference type="OMA" id="HDEDYYL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="427" mass="47381" checksum="60EA4C5B194EB805" modified="2012-09-05" version="1">MRLGFRKLFKRDKSKKLGQESEYSESVTSFKDKISQPSPLQVDSSDSSAKMSVKEFKRRSSNELLGNQNQPQPLFKTRRKPAPKPNQDLSNWHTSDDDSDDNVRDNDEFEKFKQRIRQSRSTIRQAATTIQDNDSDESDDTLPLSQLRSKSQVSLVNSIASKPNKSTPSLKLQGSSHKLNYRKPPPPVSANRDSRSIKHNSQLSPNYQRQSHASYSPQSRQSTLRPPPSPAMSLQSAPGGFGYFNPYSTPGMPGMPPMPPMPPVGMPGAYPFAPPPANNLPTPPPSAPSSSNGDLNQQAMVAAQMHFQAMMNAKQSFQAYVAQHAAYLAGQQWDEEHSQYGGSEAGFDLNDDDYYLKGNSRAAKSDYGGISPGSANSRRSSNYLQAQQAQARSQMRYSEITRKAPSRESLKAPPPPPTIKHYKVPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJV0</accession>
    <name>I4YJV0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_62064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956059.1">
        <property type="nucleotide sequence ID" value="XM_006955997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJV0"/>
    <dbReference type="FunCoup" id="I4YJV0">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJV0"/>
    <dbReference type="GeneID" id="18474709"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62064"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJV0"/>
    <dbReference type="OMA" id="EIWCNDE"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="540"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="978" mass="110355" checksum="57C01A0F697E385A" modified="2012-09-05" version="1">MTANKFKKPNKKDKKQSNKPSNLDNNTFKQEILALGGDDDDFKLLNGVESDEEATFDNVDNNDPNLLKDLKDLYKSLDFNSVQPVEREEDEEQDENDEESAASEGENANGSVDGNDSEIANEEDSEEEDEEDDEEDREEDANDIDPLSEIDPEGPFAQIPQWFLQPLPELKKSKPNPNSQSSTDGRIQHANKLLEDLPKSAQSSSAVSSSDKKFLDQMLKSGTLNDRVSALALLIAESPIHAISSLEALKNMASKPKREEALRAMKALVDWLAGPHGLPANRKLIYIADQPNLTHPGVKDKHLTFWAFENWLKAYFFEVLQLLESFTHDTLTFVKQQAIMLIFQLLKDKPEQEHNLLRLLINKLGDPSRQVASKASNQLLVILQAHPAMKGIISREVGDLIFRPHISESAKYYAIITLNQIMFTKADTGVANKLIEIYFNCFKDFLREEEAYVKKTKEDAKNAKKNKKQHGKNDKKDKKGKKEEAEEDPEMIEEKKSKMIAGILAGIHRAMPYANIEEKIFDNYMDTLFRITHTGTFNIAIQALQLINQVTIIKETISDRFYRTLYESLLDQRLSTSSKQSMYLNLLFSAVKRDPSNARVAAFVKRILQMLLGQSPSFICGAFYHLNGLLSSHPSLRAMLDDGEENDAGGVASTSYDKFKRDPQYSNAQHSCLWELLPFTNHYHPSVAIQAKQILNGEVVRTSADLNLNTLMHFLDRFVYKNPKKDIKPKGASLMQPIAASDRSQTVANVKGATRELMVNSSEFMKKKEENVAPDMLFFHKFFNQRNKRLEEKAAKRDKRKKGSDDEDEESADDEPDQGEDVDLDKDDDDDDDVAEDGSEMDEDEVWKAMQASMPGQEDDDIEESDEDDVDPALMDDSEEEAEGEGEPEPTADDEEEEEEDDDDDDEGGLEGLVDDEDDLLSVDEMESEAGEESEAEEEESLGKRKRDDKDAKKAAKKAKKALPTFASADDYAHLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJY6</accession>
    <name>I4YJY6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956092.1">
        <property type="nucleotide sequence ID" value="XM_006956030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJY6"/>
    <dbReference type="FunCoup" id="I4YJY6">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJY6"/>
    <dbReference type="GeneID" id="18473214"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59185"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJY6"/>
    <dbReference type="OMA" id="QGQKFML"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="126" mass="13249" checksum="56EC0721FFC89DD7" modified="2012-09-05" version="1">MSWQTYVDSSLIGTGKIARGAIMGVQGGIWAISHGYQLAQDEQTAILGSFANSEATQASGIRLAGQKFLTLQADDAHVYGKKGGNGCVIVKTNQAILITEYEAPVLPGEATVVVEGLADYLRSVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK21</accession>
    <name>I4YK21_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_56087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956124.1">
        <property type="nucleotide sequence ID" value="XM_006956062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK21"/>
    <dbReference type="FunCoup" id="I4YK21">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK21"/>
    <dbReference type="GeneID" id="18472770"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56087"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065163_1_0_1"/>
    <dbReference type="InParanoid" id="I4YK21"/>
    <dbReference type="OMA" id="ACDKNRI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="34769" checksum="23262F9188BB55A8" modified="2012-09-05" version="1">MSSTIDASQILAEHSKKYKPTQISREIPIENDLNLLTAFDTNAINADELKSNRENYVKELSRDSVQNLINDLFNQPITKTLDGPLAKLPEESVYQLPREKPLPKPKALTKWQKFANEKGISHKKKDRMVFDEDEQKWVPRWGYNGINKKEENQWLHELKEGQDEDHNPASAIKGARKERSLKNVKQQLKNEGITKSIQEKQKAEAAAKRAERAQHKQELEKSLHRSKISTASLGKFDKKLSGEPTLKGQKRKFNPVTNTSDEHKSNREILDKVATGAGKLNKSTGSGSKDLVNTRRAINSTKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y508</accession>
    <name>I4Y508_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668270">
        <property type="protein sequence ID" value="EIM19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960906.1">
        <property type="nucleotide sequence ID" value="XM_006960844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y508"/>
    <dbReference type="GeneID" id="18473089"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58956"/>
    <dbReference type="HOGENOM" id="CLU_1846688_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y508"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="16532" checksum="C1CE65A43FA3BE90" modified="2012-09-05" version="1">MRTFYKAISFFEELYHQFMLDLENSPLTSQSYLKKSRHLNYYLQNSFPFKIVLEKLASIDDEKLYIRIKIYPEQQYFSIEYSKELQTYYDNFIGIFIPGIAHFSDNISITYSKASQQELEKLGLYVSSLPQQLFSVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y546</accession>
    <name>I4Y546_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960872.1">
        <property type="nucleotide sequence ID" value="XM_006960810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y546"/>
    <dbReference type="GeneID" id="18475809"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70885"/>
    <dbReference type="HOGENOM" id="CLU_2801182_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y546"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697519" evidence="1">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="68" mass="7115" checksum="754D7F2C582B34BC" modified="2012-09-05" version="1" fragment="single">MKIQLVIAAILASVYAEVVTTAPVPGVTQSYVVDYQYNANDVIYTSTTLSTINPSATSTSANTATNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y556</accession>
    <name>I4Y556_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960854.1">
        <property type="nucleotide sequence ID" value="XM_006960792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y556"/>
    <dbReference type="STRING" id="671144.I4Y556"/>
    <dbReference type="GeneID" id="18474652"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61639"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017137_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y556"/>
    <dbReference type="OMA" id="CIRCLIV"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52315" checksum="8869EAE30964E749" modified="2012-09-05" version="1">MKYGKQFEQLNEEFPEEWQEKSIEYKHLKKLLTDVVEELNTIGLNKAKLLDLLLSRSEDTHIEYVLNGPLNQPQPQLIVQFNDDNSKREWLSLFNLQNNSSGLSEVSASTSNKDMEKQQSDAVEEIYTEGTDPNNKEIHINLNADAKFLGALTAAFDKLEALQLVEKKKFAKQVETLCNAITGVTGPGAVSHSAFSLHRKKTNDLYAWREIFTLWVESAIYEGITESNRGERDVESAEKRLNAFAAEVVKRGLGDSRTMKSKQSRDALDQFLELNMALLDIKKFYTANLEAARKILKKHMKMTALPTDAFYSFAGVEGSALQTATSSQNSNFGWTFYTISLPRVLLSRLTETLIPIIPSIDDYNCLICQEIAFKPIRLSCSHIFCVRCLVKMQKRGQKDCPLCRAPVVLAANRDNLDQALVGYMELWFPKEVRKKSKANDKEAQKEHYQETGIDEISCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y587</accession>
    <name>I4Y587_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_70850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668258">
        <property type="protein sequence ID" value="EIM19129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960825.1">
        <property type="nucleotide sequence ID" value="XM_006960763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y587"/>
    <dbReference type="FunCoup" id="I4Y587">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y587"/>
    <dbReference type="GeneID" id="18475800"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70850"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004219_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y587"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="394"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="686"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116482" checksum="0C48FE25E5EA7975" modified="2012-09-05" version="1">MSLAPSDHISTLWCHSEGLARLLYSPDGNKLYTAGNDSMLRAFSLNPDKSLGESQVIDAHTDSIQSIQHTKDVLITACEDGCVRSFDLSDNSFKELVVKSALAARWIGVENVRGKARRIALASDELIVKVVDLNDHLRVSLLQGHTKSVRSATWSPLGGVLATSSCDGSIKIWKEKNSQFECIKTIDGIIKADDPESEYGVAANWHPSGKFIVCTTRTHDIAIIDTENYKKIGSLSQDGHTSDVAELSWSPNGRYLASSGKDGYLIIWSIDDRRPISKTKCDALITSISWHPTENVLAFIDTSASASRWLKPIPEAAESPCLGKILYADETMAMQQQPSEEIDASKDDDLILKELEGDDGEDLDDFAIDDDEPLDKVVDKPRPGATVQFDPGQRPFQPGSTPQRLDRRYLAFNMLGVIHSVDQDTHNLVTVEFHDKSARRGYSFQDHFKSSLCALGEEGALYASTGNTSMIVYKPFDSWSSQQDWSTRLPDGESASILACGSKFVVVSTSKNYLRFFTTSGIQRYVINYGKDVVTASAGKQYFVAVSRSSGGASNGYQNLVYDVIDLSTFEYVQSGTVPLAKGVEITWLGFSSDIDVPVMYDSNGLLSILDKFATPMQARWVPLLDTNTLERRQDKDERYWPVGVTNTQLMCIILKGSEQYPYFPRPLISELDIKIPLLGMDSQQGQLEESVMRDSLLLNHARDSNEEDEFEEEIKQHEIQIDKGILQLINTACKADKLQRALDAAAMLNQFTSIDAAMKIAAFFHLPSLQDRIYLLKEDKISQRERKQNTKKISYKDRVMSRPLSTMPISQTNQNSNTAPAFPARKPHMRRRFDAPVEDVDMDSIANETQEVVDVGNSVVDDDEPIAFSDDDDVDVEANAESSSSNKRKVDAIDDSQMTFSPPESSKIRLSNEALPPPPIPGMASQQPSMQANPFAKSANPFAKAPTDNSTTLKKGSIHQSDSFFERADKPMNKKKAASKKQSSLLGHFKKPEEGGLHERDENSAIDSEEPREKTSTREKLEKFRAKNHTASQDQESEQVEPIEQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M0</accession>
    <name>I4Y5M0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960657.1">
        <property type="nucleotide sequence ID" value="XM_006960595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5M0"/>
    <dbReference type="STRING" id="671144.I4Y5M0"/>
    <dbReference type="GeneID" id="18474593"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61540"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326835_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5M0"/>
    <dbReference type="OMA" id="VINCETF"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="881" mass="97219" checksum="3625B28223D644ED" modified="2012-09-05" version="1">MTDQTILTSEVVKTRDQYGRLLVNQYLLLSELGKGQHGRVREAIDTETNERFAVKIVDRSPKKRLLGSKSRPSTADSSFNNLNKKPTDEKICKEIAILKKIRHDNVVRLKEIIDDGASKTIYMILELMDGGEVQWKQESFNDLGDRIYYPTMTINIARSTLTDVILGLEYLHYQGIIHRDIKPANLLWTADHRVKISDFGVSHFSYALRAQSPEQSPLFTMSTIENKSETQLDSPQSSLESEPVFSDQDLAKTAGSPAFFAPELCFQRSSRNTPRPPITNAIDVWALGVTLYCLLFGNVPFTAENEYALFNVIPTQDVIYPPYAGSDRLPIYETEEGAQLRDLLDKLFEKDPTKRITLAQVKTHPWILRGIHEPNEWLKHTDVHASPAVQVTNEEVASALNFKGRLKRGWRHIANAFNAATGATGKPRRDSIASSYNYHSQSDLDPTSDDNNPYAPTSAIHQLYKDPTLQNQPSQSRRFSFLSTNPPNNRVEEASNNVPVIVAPQPRLARAASTSSQSSRSQQNPSDPSSRRQSIHYLSSSSVLQSPNMSMSNELVSSPTFSPQQSVQRKPSPVPPVPMLRGNSDTCTLSSTDYEHDTSTVSRSSAASPASAKKGSIRGFLKGLTLGNRKSSVSSTNSRLGASDSPEQREFRKVSASSLSPSSNQVHRPAALAAPPVQPPYDDDVDIDVQLSGHSDSSDDELDDDNGGTLSHSQSSNLRSSIIAIDDQSDDDSDDPSELSQPTHYWTNKGDGWKHVDMTPTPNISNVQSTSDSTPQSSSIGGNESMTDTASLATFKLQKDTSQQSHQVIKTYDEVEESSSSEDDEPDTLEITPRRSRTSSFAITSRSPSMSLSPSKVNQSAKLAPPPPVSNESIDKPRNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y618</accession>
    <name>I4Y618_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_41396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EIM19410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960498.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671144.I4Y618"/>
    <dbReference type="GeneID" id="18472212"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41396"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="InParanoid" id="I4Y618"/>
    <dbReference type="OMA" id="RRNRNMS"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
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        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="10">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="11108" checksum="AF7037448E56D603" modified="2012-09-05" version="1" fragment="single">WCSQGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDSVTYTEHAKRKTVTALDVVYALKRQGRILYGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y676</accession>
    <name>I4Y676_WALMC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WALSEDRAFT_58727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
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        <lineage>
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            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y676"/>
    <dbReference type="GeneID" id="18473058"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58727"/>
    <dbReference type="eggNOG" id="ENOG502SD3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570128_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y676"/>
    <dbReference type="OMA" id="NTIPQRE"/>
    <dbReference type="OrthoDB" id="2554322at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="479" mass="54178" checksum="B86C6CF7FC80909F" modified="2012-09-05" version="1">MNSQLKLININDNKGLKNEIKEEWDQDFEFGETEIAINNKSRISEWDEDIQKSDYTQSTLFDSFNSSKANSLRSLIDNNIDDNTTHFRHSRHISFNDEFKPSAINKKPFRRNSLSDLRIPQFVKNSQQGLKIQLGSVKEFSKGVDELKRLRDDFVLLKDKINWPSNDLPVDLQRICSKLDLYWADVWESANVLIELASGSGIVPIAEHQEGQENLPRSLTTSPANLNSLTNTTNNTLSDKQLDILKSMLQKPAISDYEESPRGSTTIGPPTGLLNDEQAFKPPNSPSTPTQIRRSRLRRASKAGLNSFKDLVNKFVNSIDSPTKLNETTNTIPHLDESNLRTPPTLHRKRPSLAQLFARKASTSSLTRKTSLSSQRKTSMNIPPIGAVDLNDENTPIQTPTKPKRLNSEFRSYSENLSTPKQREEKINFPMSSPINRSQSTGECRLQLTPDALPQLLGHLNQVKSKCQESLSEWKDIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y682</accession>
    <name>I4Y682_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960444.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y682">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y682"/>
    <dbReference type="GeneID" id="18474545"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61462"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
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    <dbReference type="OMA" id="CRDIRHH"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="504"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1390" mass="155501" checksum="C9555E3712810930" modified="2012-09-05" version="1">MESNLLDLVHSQITVLTSTMKSNSIWFNHTTKRSNLDNLASDVGLQRFKKSDSQLDLFSSLSYLSSKLPSLKQLDTIVIFSPFLDIVSSANTSGPITLASLDSIDKFLSSHLLTTSSINALATINKITDAITHCTFDPSDNQTDDAILSRILDIINFVLTSDLVTLCSDSTVCALIQTNLSMASQIRLSPALRNSAERTMQSVVRSLVLSYKSRYQFSQPSDSPIDTPQTSQDISTPFSHPTMSELISVLVKLLDPHDPKHTDTIRLASLRILDVALTTGGKTLSNVQSIRSTLSDQGCKYLFQLARLEASPLLIMTMRVITLLFDTFKPYLKLQQELFMSFLVERLSPSNSNSSDLNSPDYQPPFDPYYTWEASVMPQEAHNVDNENDKMLNTSGSATPSLAPAKSAKPAFGTTRQLLLETLVYFIHRPGFLSELWLNYDSDIDCDDIFERTLSFIVQGIFPQENSSLDSQILCLDATSSFLSQMNETIVKTDDEANLQYPTNIALKKSRKKVILNGARKFNIKPTTGLDYLARHGIIDINFDEDNKWTKETSESVAKFLKQCARLDKRLLGDYLSRPDNIEVLKSFFSLFNFENLSVADSMRQALETFRLPGEAQQIARITEVYAESYFSSSPKGINSQDAVYVLAYSVILLNTDLHNPQNRARRMSIDDYKRNLRGVNDGKDFSPELLEDVYHSIRKREIVMPEEHHDQLGFDYAWKEMLFRSKTAGTVTDATSPNLVKPIFESSYRKLLVGLSYAFASFNDSFAISKVIEAYRHLMMLSSRLKIAHIPDLAFISLRRATGMFVSRFSEDEFTQATVRLSENAEPINLSVTSFTVQFGEDVRAQLAAWTCFTVILKGHLDSARQSWDDIFEIFLSLFHNDLLPESIQSMEDFLGGSTPIPAQGHSSTEKNEIGASNNSNSTSLLSTLSSYLLSPYSNESHMAPQATEGDIEATLKSIDCVNVCNLDILYKDLLKLSSETFAFALSSLRGLVEKRTTEKLVGLEKYNKKGTPPITIPYDRQTVFLLEVMISMSVRNNDLVEVSWPIVFPVLEKILSFSNVFSTLLTERAAVGLSKLTLAISKKESLHEDLFISIDLLRSLPHQQLLASISDHLLTLVEGILASPEILHNATEWRLTMSLLQSSSGDGERSLAILSRIIENQLTSDSINGVLSILLSLSYMENTRALEMLLSLRDASISNSASEWDAKLEPLGLTLTELCLHPSRQIRGKAIEGLSLILLEHPEKGLSVFPDVLFPLLEKLLRPDVFKRDPSPGGMLSTRAGATNLVCKMWLLVDLKTPDGEVEKNWLDLLDFLDRFVSSITNVNQNSVQESILENLKNLLLVMSTNGIISTNEEKQEAYQLYNKTVERVDLFLQGFVNDVLCDSNQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6E7</accession>
    <name>I4Y6E7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_70560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960462.1">
        <property type="nucleotide sequence ID" value="XM_006960400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6E7"/>
    <dbReference type="FunCoup" id="I4Y6E7">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6E7"/>
    <dbReference type="GeneID" id="18475759"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70560"/>
    <dbReference type="eggNOG" id="KOG2589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774345_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6E7"/>
    <dbReference type="OMA" id="THKMNQR"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="98"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="358" mass="41289" checksum="5FC05AF24D9ED5AA" modified="2012-09-05" version="1">MSDLDRLSECDSLISTILLDIVWNFNVVKSSNCDLNTNNIKDLVIESLSKYNYNPNKLVDALLSLDFIKKHLRRKQLSYKSLFRDHLHVYSLLFHPSTPFEIRYNRRLSEFTKKSEYSLVATKNIPKDTLISNCLATLIKISHDQDKVLRDSNNDWSILTSLTTGTRIFLGPARFANHDCDNNVQLERTQNHVYFRTNQWIKSGQEVLLNYGNHYFGENNENCFCLTCETNNNGAFKNLDYNTQDNQLRTRFNSYIRSNTTSSTNYSSASSSLTPLSSLSDLNEILCSNDKCKNDKLENNDECHTCLIHRRIYQNSWPSRNRLKNSSYQHEYMSEDSTSESSSAPSSPASSMYSDTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J9</accession>
    <name>I4Y6J9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin Cpn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960389.1">
        <property type="nucleotide sequence ID" value="XM_006960327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J9"/>
    <dbReference type="FunCoup" id="I4Y6J9">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6J9"/>
    <dbReference type="GeneID" id="18474513"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61404"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6J9"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="11401" checksum="B50DA625A0AAD6D8" modified="2012-09-05" version="1">MATTIRNIKSVLPTLDRILVQRFKPQEKTASGLFLPSSSTASPLPEATVIATGPGIRDTKTGNTIPNSVKAGDKVLLPGWGGSSIKVGEDEYYLFRDSEILAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6S4</accession>
    <name>I4Y6S4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960328.1">
        <property type="nucleotide sequence ID" value="XM_006960266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6S4"/>
    <dbReference type="GeneID" id="18471776"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33922"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6S4"/>
    <dbReference type="OMA" id="WKIRIEV"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="183" mass="21053" checksum="08C0F5648B47AE21" modified="2012-09-05" version="1">MEGREGTIVRLNWIPGHTGIYGNELAHRTANEGRTKCNHYTNIDFTLRTSYSAMRRRMRERYTAPLKIEASKLSVIKSNTSKTSAAKLTAAKTAKILNELPRATRCLATQLRTGHFPTTKSYRYRFKLIDSPKCRTCGIDDSISHRIFVCRRHIMARITLRRKITKINIRFELGPMLRNAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6V1</accession>
    <name>I4Y6V1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960201.1">
        <property type="nucleotide sequence ID" value="XM_006960139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6V1"/>
    <dbReference type="GeneID" id="18471754"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33835"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_659228_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6V1"/>
    <dbReference type="OMA" id="CRDEDIN"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="417" mass="47726" checksum="621699B6FEA63C60" modified="2012-09-05" version="1">MIRNIRDILINLLEKSNKADSDRVNELTNELLDDKLTLSQLFKSLSAILKKHCAPIRDSLIDRFLSTSFDNLTQSLELFLTLLEQMKIDILNHQLIAHRQLILQSAIEIEFQYFEMRRQSDELSIENTINCLSISKGNTIRETFFLNVLQQLQSNGQLPETLLLDKSKLDNSHQQIQDLTLISLLLLLARQTLNGFNSSSLKQFTVNELQELKSELFVILNNGKIPSPLFKTQQNNKGLTFKVVDLIQSSSNQSTLFSQLSDKTILMALTHITRAVNKKLGYIDSSPSTELLQRLKDWFDLHYNKQSNVYHLIRKRLYDNLTQQILEGFTTISSNLNEPCVIDILTISKRLSNILDFNYKTFEGLYAKLLNTSITSDIASSHKHKQITKSQAQGEGDNDTDNNKLPFHKNEASIIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6W7</accession>
    <name>I4Y6W7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33847</name>
        <name evidence="11" type="ORF">WALSEDRAFT_34075</name>
        <name evidence="14" type="ORF">WALSEDRAFT_59383</name>
        <name evidence="15" type="ORF">WALSEDRAFT_59414</name>
        <name evidence="13" type="ORF">WALSEDRAFT_59924</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="12">CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956413.1">
        <property type="nucleotide sequence ID" value="XM_006956351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956456.1">
        <property type="nucleotide sequence ID" value="XM_006956394.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957417.1">
        <property type="nucleotide sequence ID" value="XM_006957355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960217.1">
        <property type="nucleotide sequence ID" value="XM_006960155.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960559.1">
        <property type="nucleotide sequence ID" value="XM_006960497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6W7"/>
    <dbReference type="STRING" id="671144.I4Y6W7"/>
    <dbReference type="GeneID" id="18471759"/>
    <dbReference type="GeneID" id="18471809"/>
    <dbReference type="GeneID" id="18473323"/>
    <dbReference type="GeneID" id="18473340"/>
    <dbReference type="GeneID" id="18473630"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33847"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34075"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59383"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59414"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59924"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="OMA" id="THRFKPG"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="15580" checksum="F1E597F90150C19E" modified="2012-09-05" version="1">MARTKQTARKSTGGKAPRKQLATKAARKTAAPQAAGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDVQLARRLRGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y3</accession>
    <name>I4Y6Y3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_21974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960233.1">
        <property type="nucleotide sequence ID" value="XM_006960171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y3"/>
    <dbReference type="FunCoup" id="I4Y6Y3">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6Y3"/>
    <dbReference type="GeneID" id="18470905"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21974"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Y3"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004014">
        <property type="entry name" value="PRK05477.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="366"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="515" mass="58379" checksum="19EE0FE38CA6C001" modified="2012-09-05" version="1">MQISRILQNIPKKIKSKPKKSSWLEEYNLIIGLEIHAQLNASIKLFSSEVTNDFSKPNTSVSSFDASIPGTLPILNKEPYWKAIKASLALDCAVSPTSSFDRKHYSYYDLPQGYQITQQYNPLAKDGFIQFNANLDDNITRDFKVRLSRIQLEQDTGKAYFHESSKTPLVDLNRCGVALIEIVTKPDMTSPIEAVSFVKKLRSILRSIDVCNGNMEEGNLRADVNVNVQKKDNLALKTPRVEIKNLNSLKSMTAAINYEYERHARAIQNGRLEDIQQDTLGWNVTDGQTFKMRSKEDAIDYRYMPDPNLRPVSVTEVKLDEVRSKIEILPDQIRQRLISQYGLSARDVNVLLTVNEDLSGDESIINYFERLAQVSKHPQLAVNWVIHELLGQLSQRHKSFKEDIITVERLNELISLIEANQVTSTAAKKVFSEMFDDTESSASNILDRLDLRVLDGDKLEKVVNQAIEELPDESNKARQGNEKVLRRIIGQVMKLAGGKADGSEVERALRQKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y736</accession>
    <name>I4Y736_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_9677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960101.1">
        <property type="nucleotide sequence ID" value="XM_006960039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y736"/>
    <dbReference type="FunCoup" id="I4Y736">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y736"/>
    <dbReference type="GeneID" id="18475851"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9677"/>
    <dbReference type="eggNOG" id="KOG1497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028132_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y736"/>
    <dbReference type="OMA" id="HKEQCTI"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="81"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="253" mass="28970" checksum="F4649CE208E1960E" modified="2012-09-05" version="1" fragment="single">SNDEYTSSANQLVKLNFDLLNHNDLLNIYIKILRLYLEDDDYITSEIYLNRSASLLHQTTDKSIILAYKLSQARILDFKREFERSSLTFQELSFDKDLDINERLNSLDSAIITAILAPAGPQRSRILNTLYRDERSKSLETFSILEKVFFDRILFKNDITSFEQNLSSHQLAKINEPPLDDQGRRQGPSNVLERAMIEHNILAASKIYSNITIDGLANLLDLSPSAAESFTSKMILQSRLDAYIDQVLNAIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G0</accession>
    <name>I4Y7G0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_33706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960043.1">
        <property type="nucleotide sequence ID" value="XM_006959981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G0"/>
    <dbReference type="GeneID" id="18471733"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33706"/>
    <dbReference type="eggNOG" id="ENOG502QTW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y7G0"/>
    <dbReference type="OMA" id="HYYLLIG"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="3">
        <location>
            <begin position="412"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="551" mass="62620" checksum="FAE62E098F05B876" modified="2012-09-05" version="1">MLRRITANIPKSTPRICSNSKIIPNISYKPILAPKVRFLSHSHVRLDNPFNQQPSPGPQVTGVGEYDGDKSKKKSDDKQTLVDVLSSNPAFAAVVSTLLGLSVIFACGGAYMIWYKWSVLNKIEDAFAPGYDPATELARMSDETGNSDDEIHINRPEQPVIKDIINGNKPGKYYLLLGQKGTGKATMILDAMYECNSDRIAYCETHPDLEVFRLRIGKALNYEFLEDFYGALFQRREPRDAGPLLDIERAMSKLEKVAMRIRQKKGKPIVFVFNNLHLLNNDETGVAVIHQLQQRAEAWAECGIATFVFTSDDYWVLDKLKKNANRMKILSVNDLGHDDSIRAMKRLRKTLYNYNIDDPLVRDLPDQGEGVYEEVYRLIGGRMSHIAHVSREFDMLAAAQKLVAVEKAWLQSQIGLIPDHDDDVMDEQKWSSCSWCLLKYLARQKTPGNEEEDDEEDLPDPIDPAASPHVSYYKARQLMTRTDFLEPLDRLNIVSMDVNHNVRMDSHVLLTAAREVVSREGFDQDLETTMDRVSDIEWLGRTRRLVVTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G4</accession>
    <name>I4Y7G4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960047.1">
        <property type="nucleotide sequence ID" value="XM_006959985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G4"/>
    <dbReference type="STRING" id="671144.I4Y7G4"/>
    <dbReference type="GeneID" id="18474415"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61246"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_9_1"/>
    <dbReference type="InParanoid" id="I4Y7G4"/>
    <dbReference type="OMA" id="HDENGYT"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16602" checksum="F90BB1163588D314" modified="2012-09-05" version="1">MTIFYNQPSNFEFPIEFFIEEAAPRKHTNATPSTSKPRLDLLEYENSYEARLNLAGYKKEELDISIHDHKITVKASHPAEENKDNKFNYLINESRSSPEASRTWKIPEHVTKDNIHAAYTDGLLTLRYSRHAPESEPKKININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7U5</accession>
    <name>I4Y7U5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959966.1">
        <property type="nucleotide sequence ID" value="XM_006959904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7U5"/>
    <dbReference type="FunCoup" id="I4Y7U5">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7U5"/>
    <dbReference type="GeneID" id="18474388"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61199"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7U5"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="275"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="844" mass="93995" checksum="5D59CF9F8B6045DF" modified="2012-09-05" version="1">MAITVTPLAGSGRVNTEERNTGEPFCYLLEIEDARILLDCGSRDWEANDESAFYYEKKLREIAPTIDLVLLSHASTKHSGFYAYAYTHYGLKCPAYCSLPVKELARLSTLEDIIGWRGERDIEGLHNDDELWCVPTREENRAAWTSVKDVRYHQPQHLYGKLRGVTITAYSSGHTLGGTLWKIRAPSVGTILYAVGINHMKERHLDGTALIRGDQGGLTVHEQLVRPGLVITDSERGDCVNAKRKDRDAALLDIINRTLQSGNSLLLPCDPTSRILELLVLLDQHWTYIRDKDPSFRIPLCLISNTGTDMLKFVRGLMEFFGGATAAGDNSREEAERRYKENRGVLDFKTLNIFTSVDALEAAYPGTPKLVLAVPYSMSYGGSRRLFHSFSNNPGNAIVLTSRGAPGSLARDLFDRWNGKQNDKWGSGKLGEAVQGDWNIPITEHSKVPLLGEELEAYQATERINREQEAARQAADSRRRRMMEADAQEEDDEEDDFEGDSSSDEDDKVVEKEEQQKEEDGNGLQQISYDIYLKGHSTRGATSFFKSAQGSAPRFRMFPFNDIKRKMDSYGEVIDAESWVSRGRELERQAIEQDQEHEAKRRKMEEEADATPLEPPSKYISENVEVGVNCQVMYIDLEGLNDSRAIKNIMPRLNPRKMILVGGTQTSSNSLINAFEAISAMTKDIYVPNMGETIKIGEHTHSYTFTLGDSLVNNVHMAPFEDFVVGHAIGKMAYHEEALVPTFEVATSAAQETTANVPTSLYIGDMKLTSLKAKLVGLGLSAEFGGEGVLVCWNEMNSEEGAVAISKNSKGELNMTSSLIGDGDIYYTVRDAVYGMHAVIPTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7U6</accession>
    <name>I4Y7U6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959967.1">
        <property type="nucleotide sequence ID" value="XM_006959905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7U6"/>
    <dbReference type="GeneID" id="18471726"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33659"/>
    <dbReference type="HOGENOM" id="CLU_2414984_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7U6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="92" mass="9667" checksum="02831CC29901A391" modified="2012-09-05" version="1">MTSHLKQLLFPKITLGLIIALSSVVMSLWVGDMGFWLATWGAGVFVIKGGDTIVSCAGSEAESLRCLVDASTTVLSGAAIILGGHSQGWFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7U8</accession>
    <name>I4Y7U8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959969.1">
        <property type="nucleotide sequence ID" value="XM_006959907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7U8"/>
    <dbReference type="FunCoup" id="I4Y7U8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7U8"/>
    <dbReference type="GeneID" id="18474390"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61202"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y7U8"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="453" mass="49232" checksum="083B45FF7E62989B" modified="2012-09-05" version="1">MTSSILHRIPIQPPIAREAKGIYITLEDGNVFIDACGGALVTAVGHCHPTVIRAIEEQIGKLTFLWSMSVSNSPAEELAKLLVEDSDGAFNAATFYNGGSESVEAAMKVTKQYFFQKNEPQRVKFIARERSYHGDTISTLSLTGGNPYTAPFNDLYDKEHFHRVSAVYPFRNAAKAGGDAAYVASLIRELDDKFQELGPDTVCAFIAEPIAGAGLGIVKAPDGYFEGVRKICDKYGALLIYDEVLCGQGRLGTTHAWQSLGGKDRAVRPDLQTIGKCLGGGYAPIAALLFSQKVSDGIKINGNWLRHGHTYSNHILSCTAALAVQRLIKSENLLENVNAIGPYIEKKLKLSLKDSDLAPFVADIRGGGTLWGIEFSLEFVGKIAGFFPIFCYQENLLAVAVPGTPPNDDLSFSGIGDYTSIAPPFNVSKEEVDMIIEKFSRALRNTLKSLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y800</accession>
    <name>I4Y800_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959813.1">
        <property type="nucleotide sequence ID" value="XM_006959751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y800"/>
    <dbReference type="GeneID" id="18475046"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65675"/>
    <dbReference type="HOGENOM" id="CLU_1031350_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y800"/>
    <dbReference type="OMA" id="NHAHEKE"/>
    <dbReference type="OrthoDB" id="10579275at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697805" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="27257" checksum="F8725E0E23810BCC" modified="2012-09-05" version="1">MRQSLLAAACLLSIASSQPLAERGEDCVQNCFLTGIVGVGATAACGNGNDYISQAICYCQTPGLGDAYSGCLERCPEGGFEKGQHLRDEVCSAANGQQSHGGEHGQDGEQGGKQDPGHHVAGIIYDKVPQAQGNMGDYAGGDYTGGAQGGAQEGAQGGIQGDTKEGAKGGVKEGHDGHKEHEQGHAQEGIQSQSSAAPSQASSASSSSQTFLTPTQTNTKTHSNTSSMTSSASPTSTGFEDDTSSAGSNYQISWVVVLASSAALYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y825</accession>
    <name>I4Y825_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959838.1">
        <property type="nucleotide sequence ID" value="XM_006959776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y825"/>
    <dbReference type="FunCoup" id="I4Y825">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y825"/>
    <dbReference type="GeneID" id="18475048"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65698"/>
    <dbReference type="HOGENOM" id="CLU_1807710_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y825"/>
    <dbReference type="OMA" id="RAQHAYY"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16031" checksum="5A3605E3395916E0" modified="2012-09-05" version="1">MLRTIARNFTATRRAPQKSQGLDYLLENMEPLQTRSSAQNPSEYLPASSFRTGHSYYPSSFGHTPAQFFKKPSAPEGVKLPDLNRLSLSPNAMSVFLTSMGKIQSRRKTGLSWKEQRKLGKAVRRARQSGLLNTFAVGSNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A6</accession>
    <name>I4Y8A6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959686.1">
        <property type="nucleotide sequence ID" value="XM_006959624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A6"/>
    <dbReference type="FunCoup" id="I4Y8A6">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8A6"/>
    <dbReference type="GeneID" id="18474307"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61050"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8A6"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="490" mass="53766" checksum="FF3F03F135E45821" modified="2012-09-05" version="1">MSIELIADKVNKAGQDHLLTFYNTLSPTEQQELVHQIDNLDFERVDKILKLALEVEKQPPADNSFTPPPTESVKSVASAEQHSWYERGLDAIANNKLAVILMAGGQGTRLGSSNPKGMYDVGLLSHKTLFELQAQRIAKVEELAAQKSGKDADQVNILWFVMTSGPTRATTEAFFKENKYFGLKEKNVIFFEQGVLPCFTEDGKVILGNKGNVAVAPDGNGGVYTALHNKKSISPTSTKSPIDILTENGYEYIHAYCVDNSLCKVADPTFVGYSIASGVDCGAKVVQKRDAHESVGVIALRDSKFSVVEYSEIPKNLAELVDDGTGKLAFNAANIANHFYTTKFLRDEIPKFEHKIAYHIARKKIPTVDLKTGSDVKPETPNGVKMELFIFDVFPFTNLAILEVERKDEFSPLKNAPGSKSDTPETSRSDVLSLSKRYLKENGANISDEIEIELSPLVTYAGEGLSFVSGKEVVKGGYVSSVDQLKSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C8</accession>
    <name>I4Y8C8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959708.1">
        <property type="nucleotide sequence ID" value="XM_006959646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C8"/>
    <dbReference type="FunCoup" id="I4Y8C8">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8C8"/>
    <dbReference type="GeneID" id="18471686"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33463"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y8C8"/>
    <dbReference type="OMA" id="GTWTHIT"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="414" mass="45858" checksum="B2CB99642BD458EE" modified="2012-09-05" version="1">MPTPFANVPLAPPDSIFKLTAAFKQDSNPSKVNLGVGAYRDDTGKPWILPSIKKVKSDYLTNETIDHEYLPILGLPEYTQSAAKLILGDSSKAISDKRVVSAQTISGTGANHSAAAFLAKHYDFTSFGIKKQIYVSSPTWANHHSIFANVGLEPVNYPYYDKNTIGLDFDGLVNALKQAPKGSIWLLHACAHNPTGVDPTLEQWKQIAQIFQERQLFAFFDCAYQGFASGDLNKDAAAVRYFVEQNIPLLICQSFAKNAGLYGERTGALHFVGKDADETERLRTQYSVFQRAEISNPPAFGARLVSALLNDKSNFSQWEKDIKTMADRIIKMREILFDQLNNKLKTPSPNGNGWGHITSQIGMFSFTGLNPEQCQKLIDKHHIYLTANGRISMAGLNSSNVEYVAKSIDDVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L3</accession>
    <name>I4Y8L3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959562.1">
        <property type="nucleotide sequence ID" value="XM_006959500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L3"/>
    <dbReference type="FunCoup" id="I4Y8L3">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L3"/>
    <dbReference type="GeneID" id="18475658"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69880"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084855_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L3"/>
    <dbReference type="OMA" id="EAYLGEF"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="20039" checksum="D916517877B93BBA" modified="2012-09-05" version="1">MRIFSNTLRPYLGTVRASLTAALNLENFSSQIVERHNKPEIESKKSRELILQPLLITRTALEKVLIEPSVNSVRLSIKIKQADEIERILAHKFTRFMMMRAEGFVVLRRKAIEGYDISFLITNQQTEKLLKHKIVDFIIQFMEDVDKEISEMKLSLNARARIVAETYLTSFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T1</accession>
    <name>I4Y8T1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_20777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959630.1">
        <property type="nucleotide sequence ID" value="XM_006959568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T1"/>
    <dbReference type="FunCoup" id="I4Y8T1">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T1"/>
    <dbReference type="GeneID" id="18470853"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20777"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001867_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8T1"/>
    <dbReference type="OMA" id="CPLEKLW"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="855"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135673" checksum="9B47122D6BF28DFC" modified="2012-09-05" version="1">MVQSLTQSSEDKLSLEVLAYLIHAFLIKFGKLQGLNKNDFTSWLNVLSSSYGSVYKLLNETSILKLWGNSVEKDTFVSCFTKPIWLLFESEQYTKSAEIKSIFFNIIAISVISHGQSFSSQTSIIQNLEYYEHLGEPMAELLSHLDHQFNETDLTHNCLVDVSNRTFSGADLKAPRSFSRFIIKLTQLSPALVLKHVVLLQSHIDSDAYTMRNAIIECFGILITHLSTLNDESTDTESQQTQIQSFFAVLTDRFLDNNSYVRSKVIQTYLKLVELPTKFPKQRIELLESTIRHLSDKSSTVRKNATSLIIKLILTHPYGMLHGGRLNQKEWMERLQSVDTQLATIAPKLDDEKQQDENEMDEDEGSENRRKSKKFARKSQAAAENMAQHDSDQIARLRLTRSYYADALEFIQLIEKATPTIATLLSSTNKSEVLEAIEFFRVGYEYGIQSSEIGVRRMIHLIWAKDNTVIEDGKEVKGVRARVIDTYKSLYLDPISDPNMTPQQQVSRICKNLIQLTFNATLAELTSLEALISTVMSTDGIHTDVINKLWQVYSVQKDIPKAQRRGAIIIIGMMAVAKSDIVHDGIDTLIKIGLGPLGKADLALARYTCIALQRISGSVKKVKGSLQDASIRLPMSEPIFRRLQEALEHPTTSQAWFGMAEQAINAIYVLGEQPDILCNVMIKHMAQKAFTAETQGDAMQTDEESDKVIGNAFLLSQLVFTVGHVAIRHIVYLELVERELKRRKADADAEKDSKKGMKQKQAEGIDEVAGNAEDDIGDGIAAVKERELLYGENSLLAIFGPILAHICYNPRQYSFPMLRAAATLSLSKFMCVSSKFCEEHLLLLFKILETAQDPTIRCNVVIALGDIAICFSNLIVENSDKLYAGLGDKEIVVKKNTFMVLTHLILNGMVKVKGQLGEMAKCLDDTESRISDLAKLFFTELSTKDNAVYNNLPDIISHLSVGVHAVDEETFKSTMKFIFKFIEKEKQAENIIDKLCQRFRLANEEKQWRDVAFCLSLLPFKSERSFKRLIEGLPYYQDKLHEPIVYKRFTEILAKARSNKATKSDNEIKEFEGVLEKAKAKSEEEARLAGRAAGDKRYERRKSKRLSVHISKNSLKSDDEEEKENVGNGEHEHASEVEQQEAPSSKSNKPISRENTMKMSDEEEEIKPKAKAPRGRAKKSAPPPRTTRRTRRQVAISDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T9</accession>
    <name>I4Y8T9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959637.1">
        <property type="nucleotide sequence ID" value="XM_006959575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T9"/>
    <dbReference type="FunCoup" id="I4Y8T9">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T9"/>
    <dbReference type="GeneID" id="18475027"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65509"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003538_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8T9"/>
    <dbReference type="OMA" id="IYMSETQ"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000051">
        <property type="entry name" value="Probable MDR1-Mac1p interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="229"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1014" mass="115048" checksum="D591DD0E99DCA187" modified="2012-09-05" version="1">MSQLTILRGYRDPTKNDLLADYFRLPISSEPLSELAATFGVHGTGQVFSGNLYLFKSFLCFQSYDKRSCVTNIPLYSIRRVERLSTINQPGTLALSLILWHGLKLVVQLNTLKPTSDEFCNHLKHSLREQLSQMKHVKAFAKGCYSERLVGEEINDNDNDDLDHKDNDNDNDNDKTYHHGLGVQFKYPGDPKKLREKTKLRLWKEYFRLHGRNITLVRYPQFIRLVQVGLPSRLRGEMWEILSGSIYDRFANPGEYQRILELHDGQSSMATDEIEKDLNRSLPEYGAYQDPAGIAALRRVLTAYSWRNQELGYCQAMNILVAALLIYMSEEQAFWFLDKICTRILPGYYSASMYGTLLDQKVFEHLVQRTMPSLHEHFVESDIQLSVSSLPWFLSLYINSMPLVFAFRIIDCFVAFGPRVLFQVGLAALKVNYAKLIDATDDGMVLNIFRDYFASLEEPVQPNSTDPKVLNITNFSELLVVAFREFSVITDDTIIEERRRFRAGIVKSIELFSKRSAIRNLKDQARFGPDGVNKIFDHFFYALCKTPTPLAALPPSTPSKLRENEELSDRTETVIDLATFRVFLSDIATWARDEKIINNGFQERIVRSVPENEIYRKLFKSWDYTGRDALGLQDLVRGLDSVMFNGLLDNIEWFFNLHDSDNDGYLTKDELVQLSESLLFIFRAEPGDAYLGAVSKFMTNAFEYADSLIEQPQAVKETNKNDEPSQKDPLSATEVSDNCVPGSPQVSNHDPYINLATFRMVCLADELLEAFFDTDLRQSFKFEDVPQSAIDQPLIDLSTLDDIGIGSTGLVGNILGGIFSKDNKEILNGIADEIGKSIGKHQVIYRPSFGRVNSEVEIEEKRRPAPEEKDSSIVSGVANLLSSTPSWFSRSRSDIGQAEEQEMEEKTRKPEETSLLSQGDQNNGESHLASIKAAQEALANRQAFAIDQREDDDEDFDESLNDDEEAGGEFAIGSDEDDDMIDEVDAIELDDQHAIVAEEAEKILNAPVDKDQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y979</accession>
    <name>I4Y979_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_65425</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959547.1">
        <property type="nucleotide sequence ID" value="XM_006959485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y979"/>
    <dbReference type="STRING" id="671144.I4Y979"/>
    <dbReference type="GeneID" id="18475020"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65425"/>
    <dbReference type="eggNOG" id="ENOG502SJF0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="InParanoid" id="I4Y979"/>
    <dbReference type="OMA" id="IVCHKQG"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697729" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM20521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="32607" checksum="6073F8750D9D7388" modified="2012-09-05" version="1">MFSKLALASLAAYTAAHGVVSEVWVGDQWYNGANYGSANDNSPVRAMPSDGAYVAYYNVNTDDIVCGTNGQNPVSVTADITAGDQVKLRWKGDRGPTGDYWGHYEGPVLDYLMRCDGDCTQFYSSYGNARVYKIWQAGLDSSQARPDQGFWPSRPSGNGLWAMDDMSRNYGSWHTVTIPESTPEGQYILRHELINLSSADDLDGTAETPIGGPQYYPACVQLNVKAKDGVDPIWAPETPARSMYSTGDAIVNIYTPGPDGIENFDIPGPAVVNTVNRKRSARRFERHAKREAFAQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9D8</accession>
    <name>I4Y9D8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_33214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959370.1">
        <property type="nucleotide sequence ID" value="XM_006959308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9D8"/>
    <dbReference type="FunCoup" id="I4Y9D8">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9D8"/>
    <dbReference type="GeneID" id="18471637"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33214"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="I4Y9D8"/>
    <dbReference type="OMA" id="YCISIGA"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="18"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="548" mass="61545" checksum="3F986FA094A5F552" modified="2012-09-05" version="1">MFSFKVNNQPLGIVTIFIAILTSVGGMIFGYDTGQISDMLLMDDFLERFSDTVDCTSGECQLSFTRVREGLIVSLLSIGTLSGALFGAPLADYLGRRWAMCIESIVVTIGFIVQITTFTVWQQIAVGRFISGLGVGALSAAVPMYMSECVVAAFRGTAVACYQLMITFGILMAYCFCYGTRELYSDASWRIIVGLGIVLTFILGTLVWFLPESPRWLMKNNKVDEARHALERIRGAKTDFDRTVVEHDFLEIAKRIKMEQQTETSFWRSWLECFIGHPGTSKLVYRTILGMVLQSLQQLTGANYFFYYGATIFQSVGIEDSFITQIILGAVNFGCTFFGLYVMENFGRRQPLMWGGLWQSIWLFVFAAAGTAKDPEQDSNIGKLMIVSACLFIAGYASTWGPGIWIITGETFPMRTRARQAAIATTANWTWNFLISFFSPFITGDINYAYGFVFAGCNLFGAVFVYLFLYESAGLSLEAVDEMYSTKGLKAWQSEKWTPEGYEHRRDVMEQSKINTYQNENADGKRFEDEEDERISQPSVHNENATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H1</accession>
    <name>I4Y9H1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type ATPase D subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959401.1">
        <property type="nucleotide sequence ID" value="XM_006959339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H1"/>
    <dbReference type="FunCoup" id="I4Y9H1">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9H1"/>
    <dbReference type="GeneID" id="18474228"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60888"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9H1"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="27846" checksum="31BA857717E8D46B" modified="2012-09-05" version="1">MSENNQRESVFPTRMALTNTKSRLKGAQTGHSLLAKKRDALMIRFRAILKKIEEAKLKTGKVMQVAAFSLAEVNYVAGDISYQVQESAKRPQLKVKSKQENVSGVTLPGFEIERENSNEFSLTGLGRGGQKVQKCKEIYAKAIETLVELASLQTAFMILDDVIRITNRRVNAIEHVVLPRLENTIKYINSELDEMDREEFFRLKKIQSKKKRDESQDTNEEEEYTQDQAGGADILDQGKDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K5</accession>
    <name>I4Y9K5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">La-related protein 7 homolog xRRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_54912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959182.1">
        <property type="nucleotide sequence ID" value="XM_006959120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K5"/>
    <dbReference type="STRING" id="671144.I4Y9K5"/>
    <dbReference type="GeneID" id="18472700"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54912"/>
    <dbReference type="HOGENOM" id="CLU_698686_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9K5"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904868">
        <property type="term" value="P:telomerase catalytic core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045537">
        <property type="entry name" value="Lar7_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19977">
        <property type="entry name" value="xRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="La-related protein 7 homolog xRRM" evidence="1">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="395" mass="45103" checksum="192FAD41E09C517A" modified="2012-09-05" version="1">MIPRSLQFKDKQNISNNLSNDLYSLSLNTSTSSNLSNYTDDQAKDAIWWLSFALTPANVINHPQVHHHIQIHDHWVSICHLIKHTSFLNKNKPLGGQQQLIAHYVKKFPEFGLECILDNDKGICLRSKNIEFTQVELDQFKVYIQGLPSNLSDYSDLVSYLKSRISSSIQAVELPVLRSANSSNNKANLLGTYKRMVFVTLSDMESVSTVLSQWPWNSNHPIRSLHYPRWNELKDQYLAFSAKLKSENRLRKTRLETGNSNQTKHITSSNSQLDYPEGCVLEITDLDPLMNKPTLRSNLIEVVDENDIAYIEYVKAIGTAIVRFANTKSAVTAQKAIGGVILTGTRETSYWKNIPERLRMQALEKACPEIASTNISKFQSPEHYEQVDKKRHRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9P4</accession>
    <name>I4Y9P4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_39490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959219.1">
        <property type="nucleotide sequence ID" value="XM_006959157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9P4"/>
    <dbReference type="FunCoup" id="I4Y9P4">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9P4"/>
    <dbReference type="GeneID" id="18472119"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39490"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="InParanoid" id="I4Y9P4"/>
    <dbReference type="OMA" id="MDTQAFC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="407"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="537" mass="60937" checksum="9BD49EAAE65A2926" modified="2012-09-05" version="1">MLRNLSKLNNRQFFRNNRNYTHYFTTPIFYVNADPHIGHLYSIVVTDALARYSKLANPNDEVVYSTGTDEHGMKVQQAAAGLNTTPKELCDRISGKFRDLAKAALSSHTDYIRTTDDQHVETVHNLWNTLLANGYIYKGVHEGWYAVSDEAFYPESGIKEMFDNSTGETYKVSIETGKRVDWMSETNYKFKLAAFRLRLIEWLENNPEAIQPRTQYNAVLGALRNEEAAASDLSVSRPRSRLEWGINVPGDPEHTIYVWVDALANYLSVASRHNAWPADVHVVGKDIIRFHAVYWPALLLASNNSLPRTILSHAHWTMNGSKMSKSTGNVVDPFEVINKYSADVIRYYLLRVGGNLSNDADFKPNELDLKYKSTLQAMLGNLLSRISGKKIVKRVESAQQYGLSIDPTDSEKALYEKLKVLASKYSASMERFELGKALEVIEDTLHEANRYFTKLEPWSDKTPIEECAKGVLYARETLRIVGILLQPIMPEKSRELLDRLGLEQSVRNLVDAELNLSLTQSLQIKPSRNVLFPPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9R0</accession>
    <name>I4Y9R0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959235.1">
        <property type="nucleotide sequence ID" value="XM_006959173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9R0"/>
    <dbReference type="FunCoup" id="I4Y9R0">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9R0"/>
    <dbReference type="GeneID" id="18474177"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60808"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_0_1"/>
    <dbReference type="InParanoid" id="I4Y9R0"/>
    <dbReference type="OMA" id="LMRRNDW"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="149" mass="16640" checksum="825AA25DCDCE27FA" modified="2012-09-05" version="1">MSLIRNDPFFAELSDFDSFFAPIIRRPHGNKEGGNVLGGHSSLFRPSLDVKEVDNGYLAQLNLPGLKKEDVDISLDKGVLNVKAAQKQETVQDNKGWHIRERHFGEFSRSWGVPPELTHEDIKASLNDGVLSLNYPKKEAEGAKKVTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W4</accession>
    <name>I4Y9W4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_58028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959284.1">
        <property type="nucleotide sequence ID" value="XM_006959222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W4"/>
    <dbReference type="GeneID" id="18472977"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58028"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9W4"/>
    <dbReference type="OMA" id="EWHDELR"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="614" mass="70773" checksum="9B7D139F50A82193" modified="2012-09-05" version="1">MPKASKMKTRACDGCRRKKVKCDGIYPDKCSICKHIECTYESTEPKKYYNINYVNKLEQELAQLRNITNNNTPSTSSNVQYYSPIETIPSNDWEDLQDDQVAKDIDGLYIPGDMSGKRYYGKASMRGLFERVFLYTNLDPPDIVKREETRVLGRRLDRRAKQKSFQVNRTLPLLDETHFKNSIPFRRLEEGFSRLLSLVCALGAMFSDDTRVLVPGKEHLRFLAGFSFYEKDIQTLILLQVYIQKGAQSKNTWMVHGLTLLLVQNRGLHLSWLSEHENPIEKELGKRATWMLYILDRAHTACFGRPTLMKDDDMYLQYPSAISPNECPDNDINLVYIKEYLKLCKIHGEVIQQLYKFRKSNRGEDLIVTVNDIASLNAKLHQWLKEVHPTFSIRNTENDSDDTIFQLKSNLRVLFNNIQIFMYKPFLPRPDHSSSKFQLKSLMICANAARSVITTFANVYLDRKIAYQWNDCMTDWSVFSATIILVLSCCESRINGELYESDLDYLKKGALILRNQEHRNQLYARAFDLLIQVLKASELLSDDTFVETQESISTGRTLGINVKDQLEQNDEIVEDMLKSIRGNSNDTLIGLNDFNLPPLNGIIIDSILNGSAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA70</accession>
    <name>I4YA70_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959123.1">
        <property type="nucleotide sequence ID" value="XM_006959061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA70"/>
    <dbReference type="GeneID" id="18474135"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60743"/>
    <dbReference type="eggNOG" id="ENOG502QPKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA70"/>
    <dbReference type="OMA" id="WIFIRQV"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="435" mass="48928" checksum="0DC2128247A98F69" modified="2012-09-05" version="1">MDYIIFNFLPEIIVFSYDEHQRPNIDSEKVNKKRPQSDLQQQGNVSKNTVEDVELNQHDTQIDSDDRTPSFLQVMKQLSFIDKVIPFLVLISMIIGVVIGVFAKDGVDKTLNNLEWHGTPIPLLIGLLIMIFPPLAAVEWELFPSLFKSASLWLQLAVSFLINWTISPFVMLALAWITLPDGRMERYRRGVALVGVARCIAMVMIWNTIARGNNNLCAMNVIINSILQIILFSPYALLFVNILASASSSSPNLEINYQQVATIVAIYLCLPLAAGLLTRLIVKLTMTSSGENRFFNWINHLATIGLLYTIIVVFANQGKEVIDNIGKVFRTMVPLAFYFIIMWSVSFASFYSLHKRRSQQHKWIAKLSTGGYEQIVAQSFTASSNNFELAIAVSTAVFGADAPETLAATLGTLTEVPILLLLSYVALYLRRRLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA79</accession>
    <name>I4YA79_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959131.1">
        <property type="nucleotide sequence ID" value="XM_006959069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA79"/>
    <dbReference type="GeneID" id="18475598"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69539"/>
    <dbReference type="eggNOG" id="ENOG502RXKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517971_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA79"/>
    <dbReference type="OMA" id="QTPHIPR"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="526" mass="59513" checksum="03338945DD09896E" modified="2012-09-05" version="1">MTLTNRPMATSCTRCRARRVRCNGKQPCNACIKRGDDCLFSEKRKPGLKKGAGKQLEMRVAELEEQLSFYQNHHSHDSTSPSISTSSAFFTDNYTLNQSTVTQIVELFFHTLHLQTPFLNKSKPILRLTLNAIIYSTLTFIKSDYICPLTAITLPLGIEEQASRSRDIVLNESNNSLDIDTIQALIILSWNSLRDGHNPVSWSHLFSLSRIINLIFKTRRSPFMQSTQLISITTDDTSTAFEESKRLFWSAFIIDRLASFTTGWSFGINNNQNVELPYYNLELDGDNRRAIDGFRSYVELFLLNDDIHSLLSTEVNLSNQQEVEDWRSIHKDISERIESLIPPTNSLPEVILLYNSTVLRHHSPYAYPPLTTPIFEASENSRSVCAQAANQVNVIASKLTAEMTDQNIYNPELKGITSSPIFVWNIWVAARNHLLAYSSAHDTSQGLPIEFYTLVQSLRVLEPTSRLANVYANVLDKISSCNLDTNILATARTSFTVLKDANDLTKTSIFTTDLDILFKDIFSNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAA1</accession>
    <name>I4YAA1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_29338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959152.1">
        <property type="nucleotide sequence ID" value="XM_006959090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAA1"/>
    <dbReference type="FunCoup" id="I4YAA1">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAA1"/>
    <dbReference type="GeneID" id="18471096"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29338"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570126_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAA1"/>
    <dbReference type="OMA" id="IYEAQVE"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="479" mass="54713" checksum="53C22F4B679C30E2" modified="2012-09-05" version="1">MLSLQTWIGRRDFDRGEIPPDIELEEIGDLSEDFNESEDEDDDNREDTTEEATKRPSTIPNMQIGLRITHESDIRLTLLTNLLINFPSPGFMSLPVKLTVRGIVLHSKATIGIDSKKRQLHFCLVEPHEEEDDDDEEVETHILQSLIVESEIGDVDRHTLKNLQLRCHSVNFILAKNYSANLHTVKEAKNNAYFSRYQVKYRRRREGKTDFYARKRLVTQAKNKYNAPKYRLVVRFTNKDIICQIVSSKIQGDVVLTHARARELPKYGIKHGLTSWSAAYAVGLLVARRALTKLGLADKYEGDAEATGEYSLTEPLGDDEPRPFKVFLDVGLKRTSTGSRVFGALKGASDGGLYVPHSENRFPGYDIESKELDPEILQKYIVGGHIAEYMEELEEEDEERFKKQFSTYLEDGVGSDDIEEIYTSAHEKIRENPEFQKSTVASEKDWKSISQGYKAKKLTKSQRDTAIAQRIEAFQSQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF3</accession>
    <name>I4YAF3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FBP-1</name>
        <name evidence="16" type="ORF">WALSEDRAFT_19537</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958901.1">
        <property type="nucleotide sequence ID" value="XM_006958839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF3"/>
    <dbReference type="FunCoup" id="I4YAF3">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAF3"/>
    <dbReference type="GeneID" id="18470801"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19537"/>
    <dbReference type="eggNOG" id="KOG1458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAF3"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000002">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006779">
        <property type="entry name" value="PRK09293.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="206"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="338" mass="36681" checksum="40818EA16823A0A8" modified="2012-09-05" version="1">MSATEGTPQNTNIQTVSRHILEDQHQSPAASGDLSLLLTSVTLTSKFIANNVRKARLINLIGLAGETNVQGEDQKKLDVLSNEIMINSLRASGKTAVLVSEELDDPVFIEDEKKGKYCVTFDPLDGSSNIDAGVNVGTIFGIYKLREGSKGEIEDVLQKGSEMVAAGYTMYGASTNLVITTGSGVNGYTLDPALGEFILTHENITLPEKGSIYSFNEGNSKFFHEPVNKYLDSIKNPADGSKPYSARYIGSMVADVHRTLLYGGIFGYPGDKKTKDGKLRILYEGFPMAMLTEQAGGIATTGTERILDIKPTSIHQRVPVFLGSKHEVNQVIEFHKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAG6</accession>
    <name>I4YAG6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_64852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958951.1">
        <property type="nucleotide sequence ID" value="XM_006958889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAG6"/>
    <dbReference type="GeneID" id="18474961"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64852"/>
    <dbReference type="HOGENOM" id="CLU_1066341_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAG6"/>
    <dbReference type="OMA" id="NHAEIIH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="261" mass="30769" checksum="2A769A13BA2E10BD" modified="2012-09-05" version="1">MSEFIREAVAILEELKTKTNVKLDNKIDNSLLYTDYNSNLKLIDNNSNKLTISLKDPINWEIANKLLKDLLKYFNNLLYIIQSQSSSLLLRNWLNKFNDTVEYFIRLLHSIIEYNYREIINYNEIIHKLTNEKIPSSELQALKILLRDHYILLVDTKSEIDQEVDKDDCDKDNFKEMISLAEKLPSIYLQLIENLKEEQDHESILALSTKLTDQWNEVVYLLDEAEDEEFDDAVREFKGTYNEIFKNNTLSLGIDFDKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT6</accession>
    <name>I4YAT6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958761.1">
        <property type="nucleotide sequence ID" value="XM_006958699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT6"/>
    <dbReference type="FunCoup" id="I4YAT6">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAT6"/>
    <dbReference type="GeneID" id="18475553"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69238"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590801_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAT6"/>
    <dbReference type="OMA" id="QHPAYNK"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="434" mass="47756" checksum="0C54141C13975F64" modified="2012-09-05" version="1">MASELAPEWTDGDACSRCQSGFTTFNRKHHCRNCGRVFDSLCCHKLLALPHWGYRDPVRVCEGCYNLILRDGTKAAPPSAIRMPAQKPAAQSRAQDAADADLLKAIQLSLAESGRQEAGPAINSNRPEPPADEEEDDEMKAAIEASLKDMHSGNKTQNIEQVAESHPPRSTSHPQYNHQAKPSYELATADRDAILSFAQSVNQQQQGPPQPELAYAADRALNAKSRLLSGVSETEAKERLLIDMHAKMSESVRLYNRLLESQIEQRRNTPMHTSGPVNEVPYYQQHMPRYNTASIVPPQPAPIPSLPFSAPPIEEHRVAPSAPPTSIPQQQTIAAQTRPQPISAPYDGYPNEYQHSYPQQQVLASAPEPAPVQAPPPQQPPQISQQPIQQHQQQAKINALAGLPSAPSGLVQSPSQYEQPQSQPQQQEAMLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ8</accession>
    <name>I4YAZ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958814.1">
        <property type="nucleotide sequence ID" value="XM_006958752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ8"/>
    <dbReference type="FunCoup" id="I4YAZ8">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAZ8"/>
    <dbReference type="GeneID" id="18471574"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32863"/>
    <dbReference type="eggNOG" id="KOG3366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080463_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAZ8"/>
    <dbReference type="OMA" id="VSKGRWA"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="174" mass="19392" checksum="815CABA9490D25C6" modified="2012-09-05" version="1">MNVSRVSRQAVDFTRLTSQIGLGKDTVAQINAFRKRADEAKRQLTNLSEQKVDVDFAHYRATLKNSAVVDELEGKVKNFKPATYDVAAVNKAIDAFEAKALESAQQTEKKIAEELKDLEATLDNIQSARPFDQLTLDDVAAARPEITKTVDTMVQKGKWSVPGYKEKFGDLNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBB5</accession>
    <name>I4YBB5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958611.1">
        <property type="nucleotide sequence ID" value="XM_006958549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBB5"/>
    <dbReference type="FunCoup" id="I4YBB5">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBB5"/>
    <dbReference type="GeneID" id="18475530"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69128"/>
    <dbReference type="eggNOG" id="KOG4353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079976_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBB5"/>
    <dbReference type="OMA" id="THAFTQT"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="131" mass="14894" checksum="45DFA929D3709F92" modified="2012-09-05" version="1">MAIAKEIIDFSNDTSDSFVENYYKVTDYQRENLKEFYNDSSAVVWNGTPIQGLDSLDNLFRSLPITLHEIQSWDCHPIQDVSTNELSSILLNVNGLVSIGKQSINEFKDGKTLGKHKNKDIVLLPKTFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC6</accession>
    <name>I4YBC6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958621.1">
        <property type="nucleotide sequence ID" value="XM_006958559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC6"/>
    <dbReference type="GeneID" id="18473986"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60498"/>
    <dbReference type="HOGENOM" id="CLU_1961290_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBC6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697673" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="14424" checksum="9997897B8F435F0F" modified="2012-09-05" version="1">MSSVVIAALLTVTALVDSSVITRSQVISSLQRLKHMFNNITHLIHSVTAIRGKLTINSVGRLLTYTPFKTTAKQILPVSERQRLRTTAIKRSRRIQTMLNQKPSRTIPAVDNMRINMLETNLIKQVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ2</accession>
    <name>I4YBJ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_64599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958682.1">
        <property type="nucleotide sequence ID" value="XM_006958620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ2"/>
    <dbReference type="STRING" id="671144.I4YBJ2"/>
    <dbReference type="GeneID" id="18474944"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64599"/>
    <dbReference type="eggNOG" id="ENOG502QVWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="InParanoid" id="I4YBJ2"/>
    <dbReference type="OMA" id="SEMVLYT"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="50"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="391" mass="42260" checksum="CA32C3DEF3C72F64" modified="2012-09-05" version="1">MGEPLEKDSVESDTERGTVDKTRVYANDKPVVEIDAFEQNKNNSDYQEFKTLAALLLAETLALGVLNFPKIASEIGIVPTIIATIGLACLAWVTGYILVDFKVNHPSVMSFADVGQLIGGPILKWVLLTGVLLSGIFISASHTNSGGTALLEMSSNARCSVLLGLCIALLCFIFTIPRKYEHTAYAAFISCFSIVVACLITIIACGVNRDSWGDSNGEVTWKAFNNPGLVGVINSFTEIVFAYGGHAFIFSATAEMKNPNDFKKSLAVVQVVSTAFYITIGVGVYVLVGDANVVSPALSIPSHKVETIAYAIAMISIIVSGIIPVLTGLKQLWLELFRGKPMLTSNSWKANALIYIISTNTILLKSYIDSCKRNNCMVYLWTEWSNLAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL5</accession>
    <name>I4YBL5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958705.1">
        <property type="nucleotide sequence ID" value="XM_006958643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL5"/>
    <dbReference type="FunCoup" id="I4YBL5">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBL5"/>
    <dbReference type="GeneID" id="18474014"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60542"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_3_2_1"/>
    <dbReference type="InParanoid" id="I4YBL5"/>
    <dbReference type="OMA" id="HFWAIGW"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="32085" checksum="8A257352C4A20047" modified="2012-09-05" version="1">MAGYALCPDSPAIGYKEELTTLLSTAGGVALCSASANALNQMLEVPLDSQMARTRVRPLCTRLMSPIHAVVFAGVTGLAGVGLLATGVNAPSAALGAANIALYSGIYTPLKRVHIINTWVGSIVGAIPPLIGWTASSGRLIPDSLDWKDIGAISALPYVLYTWQFPHFNSLAHLLRPQYASSGYSMLSVSNPLKNSIVALRHAFIMLPLTAVLFPWSGLTTWNFAFTSTAINAPFAYLSWAFYREIKKNNPGDVAARRLFHASLIHLPLTLVLAMYHKRNSNHIDNYMNNSITTIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBM2</accession>
    <name>I4YBM2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958711.1">
        <property type="nucleotide sequence ID" value="XM_006958649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBM2"/>
    <dbReference type="GeneID" id="18474947"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64626"/>
    <dbReference type="HOGENOM" id="CLU_1220510_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBM2"/>
    <dbReference type="OMA" id="QRKSITH"/>
    <dbReference type="OrthoDB" id="3360765at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25277" checksum="0D22B8E4C992210F" modified="2012-09-05" version="1">MSNQDSEEGIDLDSMSYTIHDIQDDSRTDELSSPQLTACSSTSNSPPTSLRSSKSINVQRKSISSAHGQPTVKTPPSTWFKPKMKRIKINDDNSDKRKPDSKLVSFVKGAFTAFGNAEKADYSSFFSPELKATINALPYTVDGLKDVYNFITGSWSSVQVEFKYVIEHPRLMGKWGEGEVGAVAELVGNDYFGNKQLVKCLFTMVVIVNDEHKQQIKDWSEVMSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBY8</accession>
    <name>I4YBY8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958509.1">
        <property type="nucleotide sequence ID" value="XM_006958447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBY8"/>
    <dbReference type="GeneID" id="18474926"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64428"/>
    <dbReference type="HOGENOM" id="CLU_1877049_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBY8"/>
    <dbReference type="OMA" id="HEQHREY"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="16261" checksum="C7DA6B829385CAC1" modified="2012-09-05" version="1">MLRHKRNIHREKANPHVCKCGKEYSRSDILLRHQRTCSTNLELHSSRVPEPATIPTTAPQQAGYYYQYQAPTQQAFLYQQQQQQQQQHHHQQPQQHHQQYYSYQYPQAYIQTQSPMNMSNTYSNSNAPPGPYQYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ8</accession>
    <name>I4YBZ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958519.1">
        <property type="nucleotide sequence ID" value="XM_006958457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBZ8"/>
    <dbReference type="GeneID" id="18473961"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60463"/>
    <dbReference type="HOGENOM" id="CLU_1403431_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBZ8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="21546" checksum="08D9517966D518A6" modified="2012-09-05" version="1">MRTIKTMQVEILYRNGRIQILLNINNMESIVGTSCGTFNGKVGGITPSVLVFLFLFASSVKAQDGNEVHPFTQHVNLVRSPNLAVGASSLYAGKYIFDRLCPSCNTGHLYVRQECIIGLAAGLIFSIYGFYRIGGLLRSQSRSIDLDYQDNTLLRNFLGKSKVLLSLRGDRMGLNAFILLLLLFKIVIVLRTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC58</accession>
    <name>I4YC58_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1716-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_28615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958250.1">
        <property type="nucleotide sequence ID" value="XM_006958188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC58"/>
    <dbReference type="FunCoup" id="I4YC58">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC58"/>
    <dbReference type="GeneID" id="18471051"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28615"/>
    <dbReference type="eggNOG" id="KOG2734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC58"/>
    <dbReference type="OMA" id="TDWREQE"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="84"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="597" mass="67146" checksum="B3F5F90581513E3D" modified="2012-09-05" version="1">MFKLPDLPSGKNKRRFEAPTEDAIKKVRLQEEENPESHSSAGSDKGKGRAVTIADEEDEVEYVDAHEEDDIDDDEDGRFYGGGLTDEQKTILDVFDRAEQGGDEDVVLTPQGIKKQLQKFERVIAKNTELRGKYPEDPHKFIDSEADLDAAIHQLKIFAQSPAISYPQLIKTGATEQLIGLLSHENTDISLDVVEVIEELTDEDILDETEDSEEGMSNLQAFVTALLELQVLELLVSNMKRLNEENDSDVEGVFHTLGVFENMISLRPELAETLVTATDTLPWLLKRITKVEYNQNKQYSSEILAILLQDSTKNRSAVLKEKDGLDCILQALSHYMKKDPKDAEELEFLENTYNVLCTLLAESDAKVQFKEAEGVDLMILIAQEKLISRSRAIKTLDHAMSGPAGSLNSEAFVEAQGLATLFGAFMNKIPQKKSAFGAVSVQEQEEHLFGILVSLFSNLGSETPGRIRLLTKFVENNYEKVDRLFEIRENAQNRVTNRIEQDKEIDIDEDEAYLGRLEAGLFTLQLTDYVLAWLVMEDDGIKDHAEILLRRRGQSFKDVVSVLNEYADNMGDQPPNPDGSPTQREIVGHLMEYVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC83</accession>
    <name>I4YC83_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_68855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958272.1">
        <property type="nucleotide sequence ID" value="XM_006958210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC83"/>
    <dbReference type="FunCoup" id="I4YC83">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC83"/>
    <dbReference type="GeneID" id="18475480"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68855"/>
    <dbReference type="eggNOG" id="KOG2463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024666_2_0_1"/>
    <dbReference type="InParanoid" id="I4YC83"/>
    <dbReference type="OMA" id="GYELECE"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="282"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="456" mass="50006" checksum="F087116FBD0B46F9" modified="2012-09-05" version="1">MSDNGERIDKIDTTSSKAIKRLVLDAAPFLTQAPIRDLAEEFYTTPQVIAELRDEKSRKYLEMLEIQGIHINVQQADPVSYAKVSSFSKLTGDYSVLSGPDMGVLALTYALEVQENGTKRLRDAPGQAAGKKPASSDKIDKNAAPADNLAENVESVSLDDAPKKSEEEEFTTVTKGMSIAAKPRQNKNTQSQDDFGSIQVDNKSEDEDSDDEDAGEWITPDNVEDYKAVDLGHQTPQEKSQKPTSKKAPAYLKAACMTADFAMQNVLIQIGLNLVGTNGQRIKSAKSWVLRCHACFKLCRDQSKKFCPACGNSTLLRTSITTYAPKTADGAPIVKVHLKKNFQYKNRGTKYAIPSSKVGSSKTGSGLPLILREDDPDFQRAVHSEQVAKRKEEKALMKSLEKGKSGSNSAFTGQWMDPDWLPGLLAPDAKGRRTGGRGAQIGHGRRNPNEVRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCL2</accession>
    <name>I4YCL2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958388.1">
        <property type="nucleotide sequence ID" value="XM_006958326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCL2"/>
    <dbReference type="FunCoup" id="I4YCL2">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCL2"/>
    <dbReference type="GeneID" id="18473923"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60385"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_4_2_1"/>
    <dbReference type="InParanoid" id="I4YCL2"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="607" mass="66156" checksum="DD5C31F76D94AB75" modified="2012-09-05" version="1">MYSSASSSRRPSSEFKLVDAENGQNSSPATTHRRFGPSSGWKKYAVGGSLVLFILFLLSKNSPGFILGDHTPPPPPHHVHPQHTFDLPNQDVADPLIDVTKDESIKFTGPINEAEAALPASHDYIHADQSFPSFSEDASSNSDLPTSFEDDPNPAGTTGCQSPHPDATAKGRPLVQYVVMIDAGSTGSRVHAYKFNNCYSTPQLEYETFKATKPGHGLSSFADDPLGAAKSLDPLLKEAVRVIPKELHAQTPVAVKATAGLRILDSKIGPNASKEILDAVRNRLTTRYPFNVSDRPGDVAVMDGSDEGVYAWITINYLLERIGSDVDNTKVPTVAVMDLGGASTQIVFEPMSRHTDATPLADGDHKYTLTYGGKQHVLYQHSYLGYGLMQARRSVHNLIAYLYEFGNVLVPSWDEWNEDIKVPNPCMPHGTSKHVTLDPPHKSPVNVTMVGSSNGWDACNRVIELVMAKDAVCEVQPCSFNGVYQPSLMETFDGPLLAMSYFYDRLSPLGINDKTSSFARGEIQKLASHACKGEANWKKYWRGNQEALDVLYDKPEMCLDLTFMNGLLGLGYELGPQRPIGTGKKIDGVELGWTLGASIAVLDASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN1</accession>
    <name>I4YCN1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958406.1">
        <property type="nucleotide sequence ID" value="XM_006958344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN1"/>
    <dbReference type="FunCoup" id="I4YCN1">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCN1"/>
    <dbReference type="GeneID" id="18471507"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32524"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCN1"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="345"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="926" mass="106571" checksum="CE9C6A8487AC80B3" modified="2012-09-05" version="1">MTSSDQFTIKIRRDGTIFQYNSKFELINTWIGFQDSRCLHLSIANDTLIALAENTSNYPVIKCWNLLDSSKLLYNSVLEHNDEPHPISAFTISEDMSIAAIGLANGNMIIIHNLKDTIQTSEQFKSFRINLAIKEPITDLLFSRSENSLFILSPSSLLVSRFDSKGGYTISPLDDIGSQLNCLQMSPINSASVVVARDEALYLYGLEGRRATYALEGEKTFIKRFFKYIVLCMPSKSKPSVNSVTIIDLKFKYIAYKGDIAENVCEVLISGNKLHVLCDDGKVYTLHEKSVFSKLELLYKSNYYLLAFDIVADSKLEKYIEMDVHKRYADYLYQKNDYDLATQEYCKTIGYVEPSSIIRKFLDHQRIHDLVKYLQEVHYKGNANPDYTTLLLNCLIKIKDIDCLDSFITQSNNDNQVQFDLQTAVRVLRQAGYINHALQLSTTYLRHDDVLKIQIEDRKDWDAALKYLSRLSPDNVENYLHHYGRLLLEYNCQVTTHLLIELCSGSYRPKNADSDVTDQLSLRKSKFNSIAANTINYIGFNASNSSRNSSTEEDDVYKPPSPLKYFSQFINYPNQLIIFIESIMKLRFGIEFTSDNIIIKEVQSIYDEQNFNNVSASLNTILELYVQEAGASESPEIQRELHSKALMLIDNYERIPIDLNHALMICTIESFDEGKVKLWKFLEAYEEIIYHHMAQADTSTNREDEERSTDAIFESIKNFGKFVPRMYLVVLDFLSNNIEGHNNRTVIQNLLELIDNVRDEFTKKHMNDEVIRLPQMSEIVQILSKPGVHNGIVKEWIIRKVKEDEEKTKVDELLLMSYKEETIKKENQIKELNDVNKAQTFQNTRCSSTGERLELPAIHFACGHSFNMSVLADNETECPICARSHGMIRELRRNQKDLLEKHDTFIKGVSNEGFKLISSNFANKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD61</accession>
    <name>I4YD61_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_18303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958033.1">
        <property type="nucleotide sequence ID" value="XM_006957971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD61"/>
    <dbReference type="STRING" id="671144.I4YD61"/>
    <dbReference type="GeneID" id="18470760"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18303"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_3_2_1"/>
    <dbReference type="InParanoid" id="I4YD61"/>
    <dbReference type="OMA" id="PGGSYCM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12383" checksum="70779CD446DD587C" modified="2012-09-05" version="1">MQPPANELEPPKDTPITVDELKEHDGSNDKPIYVAIKGTVFDVTKKKEMYGSGQSYNIFAGKDGSRGLGMSSLNPEDAVSDYSTLSEKELSVLDDWYKFFSKRYNIVGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDF7</accession>
    <name>I4YDF7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_57114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957808.1">
        <property type="nucleotide sequence ID" value="XM_006957746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDF7"/>
    <dbReference type="GeneID" id="18472881"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57114"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026174_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDF7"/>
    <dbReference type="OMA" id="MSERHEY"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="500" mass="54986" checksum="5E650C6F312FAD2C" modified="2012-09-05" version="1">MTATATANKAYHPLPINPAAHVQSNSQSESERLQRQKPCRTLFVRNISYNADPLSVRTPFESYGELADFFDLIEKRGMCFITYFDLRSAENAFNAMQGSQIQSRPLDVHYSLPKADETQQPCERGKHQGTLSAWLESASEPINDSEFYNLLSEFGEIKEIRPYDDRDDSRYVEFFDSRAAISAFDNLNGSDFQSGKLNLYFEWDCPMLAAPSRSGGYANLIAPEQDIDKPARDFSNNADANAKNPLQKRRRGGRRQQRNEKRSKWHKDRDPRGNDAPLGENSESNIRNAYSNRVNNHYQQPYGGYKAPASTSTPYAYGSQHNTDQTARLADAQRVQALLSSLNPNTLNMAAAATPTPAPAPIPVPPPTAPMMAAPMMPQPVPTPYFASRSPPTQQPQSSLPANVMSLLQAASSNVNNSSGYPSGYQAMPSYNSYQPMPSVPSLPSMPPPPPAQPTLPAARDPRVAQQQTAPVPAPAPSASPQDAPNPQSVQALLSMLNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE30</accession>
    <name>I4YE30_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_54024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957487.1">
        <property type="nucleotide sequence ID" value="XM_006957425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE30"/>
    <dbReference type="STRING" id="671144.I4YE30"/>
    <dbReference type="GeneID" id="18472646"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54024"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_4_1_1"/>
    <dbReference type="InParanoid" id="I4YE30"/>
    <dbReference type="OMA" id="IVPTGNM"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="495" mass="54194" checksum="CB6C0F4D6E57C321" modified="2012-09-05" version="1">MTKVFRETVVEIWGSRAINYGLLSAIFIIVNSIIGSGIFSTPASVYKHAGSVGLSLMLWLAGGFISLCGSSMALEFGTGIPVSGGLKNYLERSLPNRRLLGTCFYIFYCTFLQVSTSSAISFANYILLAAGQEVTTWKMRGVAIASVSFAVLIFAFFPRAAMYTNNMFGAIKIIMLLFVIFTDIKTGFAALGGHNKLEEKPDNFNPKTLFQGTKTNVYDISTALLNCIFSYQGYDQVNAILSEVRNPESIAMATVTILSILANVAYFAGVSVDQFHDNGVTVAGFLFLNVLGDKAGNQVLPVLIALSALGHLISMSKSISVVLQVLAKEDVLIFNDIFTSSKPFGSPLAGLGVVWVVTIIFVCAPPAGEAYDFVVSLSSYPYTLMLFLCTVGAVKLRYFDNDWNPPFKAPILGLIVFILACLFLLIAPFVPPKDNDSNIPYYLSSVVSLSITLLGVVWYFVRFIIAPFLFRYKLVPKYKDLPDGSRITRYKRISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEC6</accession>
    <name>I4YEC6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957573.1">
        <property type="nucleotide sequence ID" value="XM_006957511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEC6"/>
    <dbReference type="GeneID" id="18474846"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63525"/>
    <dbReference type="HOGENOM" id="CLU_214589_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEC6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="52" mass="5690" checksum="5395A48F25EF2281" modified="2012-09-05" version="1">MRGKVAPILVASTVGILSGYYIFSVPLQQAVRDVKNEKKTEETVAPTKEKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEL1</accession>
    <name>I4YEL1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957650.1">
        <property type="nucleotide sequence ID" value="XM_006957588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEL1"/>
    <dbReference type="STRING" id="671144.I4YEL1"/>
    <dbReference type="GeneID" id="18473711"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60052"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006241_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEL1"/>
    <dbReference type="OMA" id="AHKMSRF"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="837" mass="94416" checksum="32C4AAB73A5E9D4B" modified="2012-09-05" version="1">MDGFSTLYYALYPSDNLDNKESLAALATLILSTVDQLLGKYEFLWHKDTFELTLNDLEVRNNRGFFLEGRMRVGESIQDEWITVWLLRELSKTYDFVIEIHDTDGQFLLIEAANELPNWLTPARADNRLWIHNGKLHLVPIDHTSPGPAQKRRVFEIDNTFDDLQPQEENDAWIDHRKAIQLVRNPQVETLASPSLEKAAFSRLETYPYSLGEHQHTFVAYLPPSLAKICAHTSAKVVSPERQTATSLTQKAIEAFATRDSAGTRAAQKMSRFAPDETTRCSVTVSRTAYAQMQGQKFYPPRVYKAEQWPNTGREREQREKGMRLACGFEILFDESKHSLGRESTRVHNPDADKPIEVLTENDPAFRTYIDKLAAVDFFKGEIEGSRLYNQRYEHAKRVWLSIREKESDDRFSFAQEVETLLKAPGVGKPTTDQDDDEKWMEIDATDFDDYLSQRMQASTASGAPDADVQASAATLGQFSDKLNAFVEGQGGVTEAKFADEEFSDDDGDSSGGSDEELDDADKRRIMDGLVPSLNQSEWGASTQSALQQEQQEQKDQTVNLSAAKEEDLLNKVREFADDPSETKQREEDDRLRRPYFEKEEYDGYSDSDDGIDEDTRNAERLKSAVKEIGDDEAEDIENLPQVEGDVDIDMGNEEEDFLAFSREALGIDDALWSKIISERKDRGAFVPSSTANGQQAAHTASPQPPQPPTKAPHTGVEDQHAKPARNDKLNSFEAVMAAMDDELAKTTGRPHSTHPTREDDDDQLRAMDQELKSILARVDPHDETLDDDEFESEELQSGDYSTMRNFLESFKAQSGLSGPVSNLAGSFGERLPRDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEN8</accession>
    <name>I4YEN8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_16910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957464.1">
        <property type="nucleotide sequence ID" value="XM_006957402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEN8"/>
    <dbReference type="FunCoup" id="I4YEN8">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEN8"/>
    <dbReference type="GeneID" id="18470709"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16910"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEN8"/>
    <dbReference type="OMA" id="LFTYPCP"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="69" mass="8079" checksum="51879B8560B01F6D" modified="2012-09-05" version="1">MYYDEIEIEDCSFDEDKQLFHYPCPCGDRFEISKEQLADGEDIARCPSCSLIIRIIYDPVGQLYIKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YER4</accession>
    <name>I4YER4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957697.1">
        <property type="nucleotide sequence ID" value="XM_006957635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YER4"/>
    <dbReference type="STRING" id="671144.I4YER4"/>
    <dbReference type="GeneID" id="18473728"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60082"/>
    <dbReference type="eggNOG" id="ENOG502S0EB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060402_0_0_1"/>
    <dbReference type="InParanoid" id="I4YER4"/>
    <dbReference type="OMA" id="ASTTWIE"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051211">
        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phosphatidylglycerol lysyltransferase C-terminal" evidence="6">
        <location>
            <begin position="61"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="342" mass="38893" checksum="991C1D1BB6A7E8B6" modified="2012-09-05" version="1">MKSDITDSISNSYNQPAGPSWLDQRYLVWKEFGKNQHTSESSSSEDDEEDTDKGVKEAIQGYTQHKNYVIAWGSPLCDKTRWPIVSRKFIHFCQSNGWTCVWTCVESEFEHVLAEAELNWSSLSCIRQDIVDLTHVNLTRSRDVRNNVRRSNKAGLAVQEALEIVDADKTAVEQGIHDWKKKRTGLQIATQDLQPWVDLKHRRVFYARHLESGKIWGFTVIAKISQNCQQIEHSVTFPNAPRGISEHLLHDVLETLQSEGTLYCSFGISAADKLVPTNNLSSMRMAWLSKMYNSIVAATGLTNRGAFREKFDVDHQPLFICYPKGKFGTEALNALMKSVHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW3</accession>
    <name>I4YEW3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_56727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957178.1">
        <property type="nucleotide sequence ID" value="XM_006957116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW3"/>
    <dbReference type="STRING" id="671144.I4YEW3"/>
    <dbReference type="GeneID" id="18472842"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56727"/>
    <dbReference type="eggNOG" id="ENOG502RYMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028622_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEW3"/>
    <dbReference type="OMA" id="WDLVECA"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46346" checksum="DFE7DB16FE444629" modified="2012-09-05" version="1">MLSNLLKIVKDTVVAPVGRLATGVSVSLGLADTVLETGKDYFLAADSVSVTELVFQATIHTVKVMTDNLANVLHIFTQVFNENSETLNWAWRHRTEFFTFLIDLAGAVEFSKSDKSDYNEWYMTSTKNIYAIVYQLQRLILSLVSLLANKDKSSVENLDMNTVLHTDFKHGIALPPTTTAKLNAPEEKWLFLNGICGEYQWLELGCNKLRDRFKKEITGIFNRSDGIIWDLIECAGERNEKNKRSLLQLTKSSMDAQNVLKKELVDALWPNTNGKAAHQVVMIAHSQGCLILRLVLQKILDEYKAKAQRDDLINRLNIFTFGNPGLDWKTKDGSESLHRYTKLTEHFANKEDFVAKLGILNSYDFDQRGYLNDHVFISECKGHWFGSQYSLSKDDYYLGENSMFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX3</accession>
    <name>I4YEX3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957188.1">
        <property type="nucleotide sequence ID" value="XM_006957126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX3"/>
    <dbReference type="FunCoup" id="I4YEX3">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEX3"/>
    <dbReference type="GeneID" id="18475326"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67988"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_2_1"/>
    <dbReference type="InParanoid" id="I4YEX3"/>
    <dbReference type="OMA" id="TIQIWLV"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="211" mass="23809" checksum="E1C774286FFBA3A6" modified="2012-09-05" version="1">MLTIEFIRHGETEYNITGRVQGQLDIPLNDNGRLQSTLLANRFRGAKFDILYTSDLSRTYETATILASHHTSTKLVKDARLRERSFGKYQGHTLSREERHGHLEGVESLDEMYTRCLDFYDEIIKPLSQLPGDKAIAVVSHGALLSVFLRQVLLNKMQFKLAEGVKPSSLSNTSVTKAIMNSNNQGYLLSWSDDAHLTVHKELDNADEVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX4</accession>
    <name>I4YEX4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_16382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957157.1">
        <property type="nucleotide sequence ID" value="XM_006957095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX4"/>
    <dbReference type="FunCoup" id="I4YEX4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="18470692"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16382"/>
    <dbReference type="eggNOG" id="KOG4147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117792_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEX4"/>
    <dbReference type="OMA" id="YRNVKNH"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15795" checksum="EC60A9083D25AD72" modified="2012-09-05" version="1">MSTTNLANPITSATLTIRLIKSFEFRTTKNLILKGIDLTNTTVEDLVNICKQEITTQSRFKPFRTVDLNCIKLYTQAHGHKTTNLIINVDNHHWIIDNWSQKLSDIEIDENETELSLFNRDLYDQFIQNPEIKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF04</accession>
    <name>I4YF04_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957216.1">
        <property type="nucleotide sequence ID" value="XM_006957154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF04"/>
    <dbReference type="GeneID" id="18474817"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63186"/>
    <dbReference type="eggNOG" id="ENOG502SCA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4YF04"/>
    <dbReference type="OMA" id="CGAHPVC"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984163" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="10825" checksum="2E8208BF862DDB6C" modified="2012-09-05" version="1">MIAQTVFAAAIVASVSAGWESKTGSCNTGKISCCDTNKKVQKSTGEESGILHTGDILDQVAIQCTQIPLAIGVAVEDECKNTPVCCEDVKEDGLVGVGCTPIPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF15</accession>
    <name>I4YF15_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBX-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957227.1">
        <property type="nucleotide sequence ID" value="XM_006957165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF15"/>
    <dbReference type="FunCoup" id="I4YF15">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF15"/>
    <dbReference type="GeneID" id="18473570"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59826"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF15"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33305" checksum="D38E4BF7C6B8E170" modified="2012-09-05" version="1">MASKQDLLGMGFEESRVDWALRATNNGNMEVVLDHLENNAESAVPADNEQDAQPASIKCDECGKLFKDNALAGYHAEKSGHASFSQSTEQLKPLTEEEKAERLKELKAKMDEKRKAQAEASKEDDKRNEIIRQQRGKEEQAIREDMKAKELKKDLEKKKKEKEEDRKAMLRVKQQIEADKKERAEKAAKEKALREGKLDNATPAQPAKPALPRVSASNATETRLQLRTPNGTLTTTQKVESTLTDLSDFVATQQMVEPSSLSFATTFPARTFTADEMRKSLKELELVPSAALIVKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF44</accession>
    <name>I4YF44_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_63224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957256.1">
        <property type="nucleotide sequence ID" value="XM_006957194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF44"/>
    <dbReference type="STRING" id="671144.I4YF44"/>
    <dbReference type="GeneID" id="18474822"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63224"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303881_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF44"/>
    <dbReference type="OMA" id="MERWLET"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="610"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="881"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="979" mass="107970" checksum="9B04D4363CAEF9B0" modified="2012-09-05" version="1">MGSHPSGKKIKAKYSSEAPFISYGPTYLAQHLPRPYNKVDPLNPLSEDADSSSGDFRLAETAQMLIPWRAAVDISRRANLFPYDKDVDQPSTNKDDLRNWLEAFSNHAWRRLPDHEGIEYLPQQPPIKLSAGTLHSQKDYTFDRFTHVSLEEISSSPGCIFNAGGPVIALDWCKTRRLSHPLKKSYVAISTSSSNQSVNGIGAQDLKSYKSSIQIWGHLPTHIPDPAQPQNIVSAKAQLLAVLCTNKGLPIDLKFAPTDAPDMEYDDPSHCTAGALAVTFNNGEVDVAVLPDFDLLRSFYGASDDEALYLDFIPTLSIEKPKTKGLSLEWASSNRLAVGFSNGCLGVYDVRNPIRKRQSSVRPQSYFPVHQAGVSGIAWVAIPEHNSKTLGLRVDKDLTQLVTSGYDGSIFISDLRIAGSGNNGGTSMFDHSRSLVYSISYHIFASSIVTTNFDDNIQLIGLLGTDYKRASNFAEFRSPVWNIATSTCHPFVAICGANGHVEINNPVAVMESRYKRKNINFSTDVYGIEYGRSEDKYRMIDNLSPADNKLGATKEKAKPTKKEIEREELGKYASAFPTESGVKCLAWNPDVNRSAVLASGMLSGTTRFGIVLAISCVFFVSELVVGLKTRSLALIADSFHYLSDLVAYIIAFTAAYLREHGKRLPGWTYGWHRAELVGAFFNGVFLLGLALSIFLQSIERFFNPETVDQPLAVIVLGAVGLALNIVSAAFVHDHHGHSHGHSHSKGHDHKHGDEEGDDEENAGLLSRHSHDGHNHDDEHNEVHPDSESENLHQMHNHVRLPPPIDPHGDLGMFGVFIHVVGDAINNIGVIIVGYLIYHLKSANKYYADPAASLIIAIIIFASAIPLTLRTARILLEVAPKYLDMQAIESDLLSLPNVLSIHDHHIWHLSQSDLLATLHVRVPSTLSLVEWHQVEREMRQCLVGFGINHVTIEVEANDVISRGCSEGQITRQNSICSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF97</accession>
    <name>I4YF97_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_31844</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957305.1">
        <property type="nucleotide sequence ID" value="XM_006957243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF97"/>
    <dbReference type="FunCoup" id="I4YF97">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF97"/>
    <dbReference type="GeneID" id="18471377"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31844"/>
    <dbReference type="eggNOG" id="KOG1275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002369_1_0_1"/>
    <dbReference type="InParanoid" id="I4YF97"/>
    <dbReference type="OMA" id="TQELLWT"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="438"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126974" checksum="845447A414D591C3" modified="2012-09-05" version="1">MAHRNSPVKELCLDDRGIVTLGLNGVKGTKRSAIGKWMVEEPRSSLEAMSMSPGSSEVVAGGNQLDLLVLNTNSGSLVRKIEVPEPIRFLKPGPRSSVVCGDVSGNVQIRDTRVSKAAMQHIQPHKDGLLGIESTGNILLSWGCTTRFGRVVPEPLVKVYDARMMRPLPPVSFPSGPSFVKIHPRVSTSVFISDLQGQFHVTDLSTSTGTYHMLDISSYVTSMAVSTTGNHLAFGDADGSIHIWTDLEPGQPENFNAFEGIQLDWPSEVQTPPRIDWNDRTPLNSIGLPYYDTPLLSSMPLHMPLPDSSPMFNPPTPIPISVMKGLRTDIFPAHAQNPPENKGKRNLTPSRKAGRSGRNRIGGRQSDEPKFISEQIRDNLKNGGVNNRPRLESRVENLELDISDVANMPKHYRKVEIKYSKFGIEDFDFGFYNKTPYSGLETHIANSYTNALLQILHHIKPIRAVATSQTTLPDLKDNCLLTESGFLFRMLENGKGVNCQSANFSRALSSFPQAKALGILDADISGNHNAPYGNMIQSFNRFLLEQMSVESWTFQPSPQICNNGNMSPISQLLGIESLSVSMCTDGCGSRSVRKGVTHVIEFMYPRKTLSNEVPLPVDFGSILCASIIRDTLTKHVCPVTKQFVPLHSRRIVSTFDSQFPAVLSINAGVHSKENLDIWLNPARRPGESPYNPKPEYFLPFEFGIKRTSDNVQVVTDQDKYDGDMAIYSLKAVIAQIYPDHDSNHLVSIVKISDDELDDNSKSPWYIFNDFLVRNVSPVEALSFSEWKIPSVIYYERKNVDKCVNFTALNQKIDPTILCHDLSISWNRDPKLIKHQVLSEEELPKPGSLVAIDAEFVSMDREEIEFRSDGSRSVIKPSKLSLARVSVLRGEGDLDQKPFIDDYIHTSEPVVDYLTEFSGIIHGDLEPSTSRHTLVPLKAAYRKLRLLVDMGCIFIGHGLSQDFRIINLFVPRNQIIDTVALYQKKDSHRKLSLRFLSWFLLKQDIQLDTHDSIEDARAALLLYKMYKAFEKDGRLEDVLDDIYSEGRRLNWRPPANATTTTNNQISTTPTPTPYEVKIPPQQQSQAAATGSFATIPTIFPSVSQVVSSGIPSQNSFPIVQSTAPIFNNERQAHRDPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ1</accession>
    <name>I4YFJ1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_4712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957152.1">
        <property type="nucleotide sequence ID" value="XM_006957090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ1"/>
    <dbReference type="FunCoup" id="I4YFJ1">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFJ1"/>
    <dbReference type="GeneID" id="18472408"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4712"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2729130_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFJ1"/>
    <dbReference type="OMA" id="WEPSREK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="71" mass="8495" checksum="F8BDD256249A01E3" modified="2012-09-05" version="1" fragment="single">WKKHNSRIKSKYPDGWKPKNKLSRAAMIGIKELHQYDSLQFNVASLSEKFKRSPESIRRILKSNWIPDQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFM0</accession>
    <name>I4YFM0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_36858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957419.1">
        <property type="nucleotide sequence ID" value="XM_006957357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFM0"/>
    <dbReference type="STRING" id="671144.I4YFM0"/>
    <dbReference type="GeneID" id="18471985"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36858"/>
    <dbReference type="eggNOG" id="ENOG502QVJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016579_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFM0"/>
    <dbReference type="OMA" id="HIIIATH"/>
    <dbReference type="OrthoDB" id="3357304at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="48552" checksum="E64BC9D150831C54" modified="2012-09-05" version="1">MLVIGIVLTLCTVLLSHLCFTAQYHFPLSKLNYLLQTLAVVSLLTKVSAELALISNKLYETASIWPYMFEYSAIDVPPLNWDVWKTGAWLAMLAIVSAFVNVRVRPDLFLESLSKTLSQLTHIQFLTLLFPSELEQILIFTLLGPLAVVGAALTFCDLSSSEETIKTAESIKNVCNSTLTLLFTAGLIIWGGIINRRRAWRTDGGTAAFGVSAIALAVIGTSVNFLLIKEDEVPWLQSVEWAIVMWQSWLGFWWWVGAGMGIGEVEDRRARKSKKKRRRNKNRTVESEVESMFASNGSLSSARLRRRATTTANVPSRTNTLSDNSPETSSDTFLFRLSPSYLLNYVYNSLRRAHNAAARIQAREHKRKQEQNERRWGPGEFAMSSIHPSHQNSQISTTDDDTEALTPPKRSSGWFKWTERLRRRQTDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFT2</accession>
    <name>I4YFT2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956876.1">
        <property type="nucleotide sequence ID" value="XM_006956814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFT2"/>
    <dbReference type="FunCoup" id="I4YFT2">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFT2"/>
    <dbReference type="GeneID" id="18471325"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31545"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="InParanoid" id="I4YFT2"/>
    <dbReference type="OMA" id="YPIKNIH"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="41"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="347" mass="37429" checksum="8307C9AACE877964" modified="2012-09-05" version="1">MVQNKSVIFNEVPVGEPVVGKTLKVVTEEFNLDQNIPEGSAIVKTLTLSLDPYQRGRMRPEEIKSYVPAFSIGKPIDNAGVARVIKSNSADLKENDLVYGALPFSEYAVISSKGFSNVTNSPASPQTLVGALGMPGRTAFASLEALVELKKGEAIFVSAASGAVGALVVQISKLKGLKVLASAGSDEKVKFCKEIGADHAFNYKTSDTREEIKKFGPINIFYDNVGGSTLEAVLDTIEDFGRIIACGAISQYNATEAYGIKNTFQIVAKKLTIKGFIVFYLQNQPSKNPEFSGKTIEDEFLAIMPKLVTDGSIKVKEHVYDGLDSTPVAFNDLLKGNNFGKVVIKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU1</accession>
    <name>I4YFU1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956885.1">
        <property type="nucleotide sequence ID" value="XM_006956823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU1"/>
    <dbReference type="STRING" id="671144.I4YFU1"/>
    <dbReference type="GeneID" id="18472819"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56535"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303505_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFU1"/>
    <dbReference type="OMA" id="CMERENT"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="807" mass="91636" checksum="0525093C06545DB3" modified="2012-09-05" version="1">MSLQEEGMQEKSTDEEITRADDTYTATSPVPLNREEELAELAHLRQAQPNIDEKLVKSLISVQQNSMLALNTLLFSTLSSIKPIISSDWKHVSEKYNPTKNIEHLNANVNYALQTHLHSATSGELNERIERMSYLFSPIDAKLIITLNQFAEALSLLTIGDGNTQQTKERLSSPPLSPTSSSDVYDSLQSRMSKLQVELNTQDEKSGEIWLKIETFINLINILCNERDNVSERPPSYSDLSPSQSMHRQLSQKSASSTTASIVSSVQDEKMKRDLERVTDSIDRLMRITPQLASQRVELSQKQVIEMDLAKLAGEVESSVKSSKASTSHKASNGVGKFFPKSINTRRSDNQVISSIEKGNRRRLDSQRVDMGNRLEDARTKMRVADLVDIIQRNRVGRLTEQESDFTETNPRPSSSTKSVQKSPSKDSVDSQTQNMVSQQAYIAEHNVNVGNVLVQFKTQLHGYSKELDIEVDQQARDSVILKNLSNFNVRLKLPTKVVYPQRKRVKLVERDLFEFNLQVSHQSRKSLTTPVVEPPSYPFSSMEFSSSKPSSFRCAKCSRDVASGDHVASYRDLPSEGWSEHVDNWMCHPTQELNADYYRNSISSSANPNEVLIGSNYWVFNKKNIVEKNVRVEYNDEQIQHTLKCICGSAIGGAQSEGLFRFNKVSVCPVSAHKSQPYYSYNIGHHISAELIEQSRNYGSYRYFLQDEQTGELRLLVWLFNPLVKVRTSQVRLNSTIEACKVFWKTNREEPLRDSKMNQIGKLKYPGWILDEFEDLLLNGIGSFLGDSPKRFFSDWHVGYIERVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX1</accession>
    <name>I4YFX1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_50418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956912.1">
        <property type="nucleotide sequence ID" value="XM_006956850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX1"/>
    <dbReference type="FunCoup" id="I4YFX1">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFX1"/>
    <dbReference type="GeneID" id="18472524"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50418"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130474_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFX1"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="93" mass="10779" checksum="07857A006D42BCA3" modified="2012-09-05" version="1">MLFFSVFKTLTEQTVTVELKNDLCLIGTLKSVDQFLNIKLDNVKVLDEQRYPHMMAIKNTFIRGSVVRYVQLPSESIDTQLLQDATRREATRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG21</accession>
    <name>I4YG21_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956959.1">
        <property type="nucleotide sequence ID" value="XM_006956897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG21"/>
    <dbReference type="GeneID" id="18474798"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62931"/>
    <dbReference type="eggNOG" id="ENOG502S9D0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1856851_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG21"/>
    <dbReference type="OMA" id="FGTCEPC"/>
    <dbReference type="OrthoDB" id="2525787at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="15282" checksum="5BB7A0824133B425" modified="2012-09-05" version="1">MAIIATIKAIDGDNDWSCTVRDSCRPCPEDNINDPVCQPFGNRQLLLCYDTRTSSKIDSIPAWHSCGRLPTQERNTFLKFVSLNFALTVTATMIVLIRNRQIANAQYDKLAKTIGLPDAKSPDGPLAAAGRLLKFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG65</accession>
    <name>I4YG65_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957002.1">
        <property type="nucleotide sequence ID" value="XM_006956940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG65"/>
    <dbReference type="FunCoup" id="I4YG65">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG65"/>
    <dbReference type="GeneID" id="18473507"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59703"/>
    <dbReference type="eggNOG" id="KOG3113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048955_1_1_1"/>
    <dbReference type="InParanoid" id="I4YG65"/>
    <dbReference type="OMA" id="EFRWLHC"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="281" mass="31246" checksum="1E8D63FDB2EFD6CA" modified="2012-09-05" version="1">MGADGGSFVYRSELVKTKKKPEVKSDDISRIAAWFYCALSKKLLKKPIVSCELGKLYNKEAIVEYLLNKSTYGDGQKICGHIRSLKDIKELNLTANPSFKDDVDNESMLNNSPFICPITMKEMNGKQRFVYIPKTGVVASESGLKSMNNGSKVGSCPETGQEYNFDELITLNPSSEEETVMKEQLYAKRLKQSDNKKTKKRKAAADATVQVTKAKKYDDEPVSDVVKGARQAVSDALNSSSKDVVHSDAVKSIFGPKDIPKSGRRTDAEWMTQGTWNRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGC6</accession>
    <name>I4YGC6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleotide-sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957057.1">
        <property type="nucleotide sequence ID" value="XM_006956995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGC6"/>
    <dbReference type="FunCoup" id="I4YGC6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGC6"/>
    <dbReference type="GeneID" id="18471348"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31664"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024645_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGC6"/>
    <dbReference type="OMA" id="RNFGGWA"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58094" checksum="ABA83B0ED2BB5CC6" modified="2012-09-05" version="1">MPVAEQTLYGIPLKYLSLITLALQNATLSILMRYSRVSNPDHAYNPASAVLLTEILKATISLYTAYKRTDDHTLNVNREDHLSPLFPKKRKSFLGNLPVKTPNSYKRRISLSLKDDTRPSESKLKAKILAGQIFSADSWKLSIPAILYVIQNNLAFVAASNLEVATFQVAYQMKILTTALFSVLLLGRKLSKSKWLSLVFLAIGVGIVQVQSTTTSSSQGGVHAGNPLTGFLAVAMACLTSGLAGVYFELVLKGSNVDLWVRNVQLSLFSFPPALLPVMFGKAAEGLSIFERLNLVRNFSGWAYATVLTQVLGGLVTALVIKYSDNILKGFATSISIVISSVASVVLFDFPITPGFVMGASTVLGSTMMYNKPTAAAAASSNNMPASTTSQSSHLSTPYKFDNEKDSNVDLRLSSSPKDTRSTLEKQASTFVPAHTMSESSYNVYTNNDSSYINSYGGHHAPSDSSSSDPLGESSNSSLGGSPEQYIYARPYDKKLVVEHQLNASERSHSDSPLPTPSYSGDSNPVDMAFTSSYKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE4</accession>
    <name>I4YGE4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_67911</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957073.1">
        <property type="nucleotide sequence ID" value="XM_006957011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE4"/>
    <dbReference type="FunCoup" id="I4YGE4">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGE4"/>
    <dbReference type="GeneID" id="18475315"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67911"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGE4"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="293"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="509"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="736"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="772" mass="87527" checksum="162C03C9F01FC063" modified="2012-09-05" version="1">MTADGVNQDFLFGNHNYGDLPLKADHANRPLWVSPEDGHIILEGFSPIAEQAQDFLVAIAEPVSRTSLMEEYKVTPYSLYAAVSVGLETADIIEVLNRLSKVPVPQSIIDFIKDCTMSYGKVKLVLKHNRYFVESADPETLQMLLRDQIIKNARVDSNAYLETSTAPTKGNLVIPGTKEAHSTNNANTIEAAPVDEEQADKQKKQQEKEHGDDYFTALIDIEKQDEMEDDEEVHSFEIKSEEIETVKRRCNELEYPMLEEYDFHNDTRNPNLDIDLKPVTVIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVLVLCTSSVSVMQWKQQFMQWSNVNDSQISVFTADQKEKFGGESGIVVSTYSMVANTRNRSHESQKMMDFLTSREWGFILLDEVHVVPAAMFRRVVTTIKAHSKLGLTATLVREDDKIDDLNFLIGPKLYEANWMDLAAKGHIANVQCAEVWCPMVPCFYREYLREKSRKRMLLYSMNPHKFQACQFLIDFHEDRGDKIIVFSDCVYSLEQYARKLKKPYIHGGTSQVERMRVLQRFQYDSNVNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSTDTQEMFYSTKRQGFLVDQGYAFKVITHLFGIERLPDLVYRSEKEQIELLESVLLANESAADIGSDIKASEDDLAGTIHGVTKRMTGNTSALAGGQAMSYIEKNKSANKQITNDSRHSLFKKRDKEAADRAKKKRQRLTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM1</accession>
    <name>I4YGM1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957146.1">
        <property type="nucleotide sequence ID" value="XM_006957084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM1"/>
    <dbReference type="GeneID" id="18475324"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67974"/>
    <dbReference type="HOGENOM" id="CLU_1099217_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGM1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698905" evidence="1">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="253" mass="27995" checksum="7AFB5161A8375953" modified="2012-09-05" version="1">MKTFLLVFLVFSLNCARSFQGDTRTFSTDASSGESFGGSLTKIDSQEVGGYKSTDHRDDAKSGGKFYDIQDAEGNTVSSVFYKVTQPVSKRSNFNESKPYQSEDVNDVTECVVGQLCYGGDKVVTTLKNGAYNIAMSAYNQFLEVNNNANYLHILGGAVVDFSVQVGSGQVNNWLNVRHQVHKTPSSHQDACINQNEIKQGQEAQTELLREILKVLQDRGGIEEQDQKQTMVGDYRQAHKLADEPTEHNDANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGN1</accession>
    <name>I4YGN1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_35480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956524.1">
        <property type="nucleotide sequence ID" value="XM_006956462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGN1"/>
    <dbReference type="FunCoup" id="I4YGN1">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGN1"/>
    <dbReference type="GeneID" id="18471916"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35480"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGN1"/>
    <dbReference type="OMA" id="AYSHDHK"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="220" mass="26042" checksum="BCB21B57AD7DA48A" modified="2012-09-05" version="1">MQKSTSDNRAAINEEHNTSRNQIRVAQKQEKRDKLADAIQEKKRALEGGEDVERSKNMEYSIEDNERWEKKLKDKARQSNAEFDDAEQVTHRRYRRDLSYMKPNIANYNRQKEQALGLPAGTLTEELANPDMSSTLDLHRGADSLIYADHKPTEEDLDRLTNKLNDDVQRRKNFSRKRPEKEEDKTYINDRNKVFNNKINRYFNQYTKEIRESFERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGU8</accession>
    <name>I4YGU8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_31351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956584.1">
        <property type="nucleotide sequence ID" value="XM_006956522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGU8"/>
    <dbReference type="FunCoup" id="I4YGU8">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGU8"/>
    <dbReference type="GeneID" id="18471286"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31351"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGU8"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="116"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="231" mass="24843" checksum="1F688D645B1759A2" modified="2012-09-05" version="1">MAPKGGNAKKEGGRAKKAENEANKKSAAAEAQEAKEAQKWAQGSKGKGKKEEEADKKAAQAAKKAEAARLLAEEEASQPSKPKGGANKAGNKKQSKPAGPGALSAGGINADFDKPESFGASGLDDALDMMSIVGQKSDKASMGAKAGQIERHPERRFKAAFEAYKEAEMPNVRSENPGLRLQQYNDLLYKQFQKSPDNPFNQQTVAYNATKEDKLSALEESKRVTENRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGX0</accession>
    <name>I4YGX0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PH domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956604.1">
        <property type="nucleotide sequence ID" value="XM_006956542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGX0"/>
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    <dbReference type="KEGG" id="wse:WALSEDRAFT_59494"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:P-body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:enzyme activator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="59463" checksum="5665AF783E5D0EF9" modified="2012-09-05" version="1">MDAKQKRAFNLRVLKQHDQAVEDILDGTSYAVLYSFVEGVGWKKEMVEGSMFIFTRSVVPRYGLFILNRSGPDNFITLFTGTDDLQLTGDYIIFRPADEDAIWGVWVFDASHRPRIAKCIEDIEKLAAKEKDQLPAKVDTFVDPAIASMSASPAQPSSSTTVQAGQPLSVDDLFGNFDSPALAATNAVPAASTLPTITQDFNNVSVGVAPVTENRLPQQSHQPQQPQNVQRVQQPSALSYEDSVKADGTQQLLSFLGLPPTATIENNHLAQPRPPQQTQMPTFPSAGPVSQVTPATNSAPAPISLPIDTNIAATPLPLSAVTPSERNHVVLSEELENLKKLTFEDELKKETSKQAVQPNVQQSQQFNNNFPPLGISPPTAPRAERERQQKMMQHQSSSNSLSDEASKSSPGLFNPGIRTHVRTVPKTRKASAISNIQRTSIASPSAVLDNLPPKSEQPTIITPVNGAAQVTEPSRASPQVNRQNVPASVSPQVGLDVITPTLPFLRQPNGQKLDQYTFKQALASLILENDEFLNVLYQRYMLIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ6</accession>
    <name>I4YGZ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956629.1">
        <property type="nucleotide sequence ID" value="XM_006956567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ6"/>
    <dbReference type="GeneID" id="18472806"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56385"/>
    <dbReference type="eggNOG" id="ENOG502S5H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718053_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGZ6"/>
    <dbReference type="OrthoDB" id="2596255at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="385" mass="44073" checksum="9912206DE1A336E6" modified="2012-09-05" version="1">MGICRPSLSITVKEVTCNQIKLNWSLEALSIENKESISLTLNGKPWTKAHLKHSSKEEASLIVYGLTPGMDYELELKWLSTSSSIESKSDKPLIAPLESTLRSTVEQKDSLMSELKRTRKESQRHTASIQSEIEALKRTIDKNQPNDQRSKQKILSLQGSINKANKDAEFINQRSKEINQLLPSLEAHHDRLRNEWLTKQEQARVSNDLTAQALHQHEQTFLEKQQRLSVLNHKLDKLFNRKQKLEKSIPEIQKQIDELSKEDESNIAFNRVYPTNTTASDTRHHSQRSLSFLPFDNTFSWAPPQTSSPTDSFLPFPTSASSTRPGTGTSDRKVVPTPIGRPQTHTISEPFFSHPPFQSFDDYTRRRTNSEKSTTNNNSFFYRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH67</accession>
    <name>I4YH67_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_31436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH67"/>
    <dbReference type="FunCoup" id="I4YH67">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="GeneID" id="18471300"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31436"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="InParanoid" id="I4YH67"/>
    <dbReference type="OMA" id="FCFTASK"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="540" mass="59140" checksum="9D82A90391F53B5A" modified="2012-09-05" version="1">MNNNQDVEQQLQTGSDKSGQSPEKNILYDMKQVSGSSLDNSSAYGLELSYTIKCQMINSALNEMGFGLYQLQLFLVAGKSCFADNMWIQAIALTLSWVDYEFQPYKYEMATLALYVGLVIGATFFGYSADVFGRRLSFNVTLFLSGAFGTAIGSANNFVAFCAMAAGVGLGLGGNLPVDGALFLEFLPQKQQWLLTFLSSFWSVGQLISSVAIWGFVSQSKWSCTQELADAGNCNWDTNAGWRYGLFVVGGFTLFMFTIRTIILPIKESPKYLLSQGQDEAAVAVIEHIAKKNKVPCPLSMEKLRDATRHLDDEFSTVPQKFTTREILTRNIRQMNLSHIKPLFSTKTLALNTTLLMTSWALIGLAYPLYNSFLPTYLEGKTDSDTYHTYRDYTIQAVMGIPGSLIAAGLVEMKGRWLGRRGAMAVSTLLTGVFIFLFSSTKEAHATLGFECVVSLTQNAMYGILFAYTPEAFPGPHRATGDALCSSLNRLFGLLAPIIHAFSGAASGSPTPLYVSGSLLLFCGLSQFFLPIETAGRSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH78</accession>
    <name>I4YH78_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956706.1">
        <property type="nucleotide sequence ID" value="XM_006956644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH78"/>
    <dbReference type="GeneID" id="18473422"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59555"/>
    <dbReference type="HOGENOM" id="CLU_1571827_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH78"/>
    <dbReference type="OMA" id="MAKVEHQ"/>
    <dbReference type="OrthoDB" id="10407507at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="170" mass="19650" checksum="D3147610E57629A0" modified="2012-09-05" version="1">MFAEEGVTKLHMQVNPNGWALYEGSSTRNSDRPVYTAQRDDDGVVFLNNNMETIGRSNIPKATAWRDKNINLTLNDRSYELCKPSWWRTCRRFVSYEGIQCASIRVVKGFLQIVNTDNNHVLATFTYSQWSKRKLGVIRHYSTENPSDNDRQLFTIILSIVAKVDSQRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG6</accession>
    <name>I4YHG6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956785.1">
        <property type="nucleotide sequence ID" value="XM_006956723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHG6"/>
    <dbReference type="GeneID" id="18473445"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59597"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="I4YHG6"/>
    <dbReference type="OMA" id="VYANNAW"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="513" mass="57991" checksum="C78A8BBC772EF374" modified="2012-09-05" version="1">MQVSKKPSFNSSESDKAWCKCNRAFVTRLDVYFLTWAYLSYLTKQIDSSNYKTAYVNGMQEDLNLYGDELNYFNTFYRIGYGVFIPISEAILASNIIRVSYWLPTLELIWGIATAVIAVADSAKVVYGLRFIIGICEASSYAGLMTLIVYWYRSSELAKRLSIFGTSYPLANIFTSSLQIAINEGMDGVQGLAGWRWLFIWNGIITVIIAISGYFMIPDALQESHALWMTSNMREIAEERFLRTGFRKPVKLTFRQFYILIRKALTSWITYAFTLTYAVWSFSQDSNTWLSLFLKSLTNEDGSKRFSNNQVTAIPIGGYVVQIVFMLIWAYLSDIHQRRCRYIVAQQITILVGTIILSTWPKSFGLKMFAYYFLYLSNSAGPLIVAWMSDTIGKQNTEMRTIYIGLGVCVVNAIDSFQNIFIYPASEAPNYRIGYKAAAAYAFASIVGCFVWKILAKKDPTASGLKDTNVPILMYEIKGPESNHSKASSTDSSPLGSPIEEEIGNQSVIRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHH3</accession>
    <name>I4YHH3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_35919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956792.1">
        <property type="nucleotide sequence ID" value="XM_006956730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHH3"/>
    <dbReference type="FunCoup" id="I4YHH3">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHH3"/>
    <dbReference type="GeneID" id="18471936"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35919"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="InParanoid" id="I4YHH3"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="355" mass="40406" checksum="EF31E6A1CAA42301" modified="2012-09-05" version="1">MTKFGQLVIGPPGAGKTTYVDGLSQFLPAIQRPITSINLDPAADEPPYKPDIDIRDLVSVTDIMEEHHLGPNGAMLFAFEYIDINFDWLEEKIEESENEYLVFDMPGQVELTTGHSSLINILEKLKKKLDCRLTVVHLTDAQSVADPSRYIAVCLLSLRTMLALEQPQINVLSKIDTLPRFGDLPFNLDYYTEVQDLDYICDYLNTQRHTSRLEGLNRAICEMIEDFGLVSFETLAVEDKLSMSKLVRLTDRACGYVFQGEMAEQDSALSLFTSVMGNLPSELDMDVQERWLDAREDYDEFENQLWKEEGEAVAESETKRRQQPQREEQQGQTLRPTVNTYSGSQKPIIESTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI7</accession>
    <name>I4YHI7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_67682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956804.1">
        <property type="nucleotide sequence ID" value="XM_006956742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI7"/>
    <dbReference type="FunCoup" id="I4YHI7">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHI7"/>
    <dbReference type="GeneID" id="18475282"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67682"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002562_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHI7"/>
    <dbReference type="OMA" id="YPPAYNM"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1204"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="140861" checksum="0720911F3AD558C8" modified="2012-09-05" version="1">MTLSKLKFKDKLIQKGIQTNEQLKRLQALQKELSEWDQDQIEPTSVHGVAKQLLDKSLLLHKDKHIKALVAASFVDILRICAPDAPYTLPELKDIFAFIFRQVAHLWKPPKDKRQNDVQCYQEYYYILRTMADVSCVVLVCDLPNADDIINDVFKDFLSGIRPDTSPRLQGFMADILSQLIDESNSIPTDIIEAMLIAFSDKTAKINPAKHKLVVEVCNRTSERLQKSVCQYFNEILLKVLDEEYSEQTFDEVIGAHKIIRSIHRHSPRILLSTIPQIEAELLSENNDLRDVATRTLGRMLGEPTSDNAYSSLAKEHPNTFRAWIDRRRDMSPSIRAVIVEHAPSIILTHPQLSNEIITTVSDKLRDFDDKVRATACQFFQKITYEIALTYTSRSTLDELALRCKDKKAVVRQEAFESLARMYSLAYADINLGNVNASEKFGWIPRAILAPLHISFPAQAASIKLQVERTLVKYILPLNAESEVAWVDRFLKVYEVLSDDEKKALLTLTGVCNSAQRLYTIRYVECCEEFNNDRDDKEKKERILSYIKLVSSLFPEDSKASTDLQEFVKLNETRLYKTLKIAMDPQQCDFKTLQKCQAELHRRLEQISGNNKTLPSTFDALLLKSTYQFVNKSSIPHLLKKYVNGSMSAHSVLLAIAKFTPLMFKNHISELVKQINDERSALVALRSLAAIAKADRSSIPTEKRFTDRLIRFANQGSHEEIKFATRILSYVDSAQETLKNITQATINDLSLTNEEGLMKRMSFLAEVAKSSPDIVQDQVEAMYEFISNDLMQRPHNSVDPDVDIDMEWVDDEDRIDALTFAKVDALRLCTYITKMKSDNPDQEVEMAKTVGQLFSKILRKKGDVLTLVEEEEMDSDVKNDDEEKYQLPAFVRSRLRLRTLLSLLKMAQDERLEKEIVRSKFLLMSVAVQDVAYSVRRIYLDKLVKYLARFKIPYHYNVYVFLTAHEPVPDITTSSQIYVQSMLRRQPPKVRLNAFEMIFYRLLHTLAHHPDFSSHPADIEATSKYINFYLEMVATIENISLLYYLAGRLKTVRDITTKDNSINLYILSELGQHLTSTLANQRKWTLASYEGKVKLATDIFKPLPSSEVQREISQKVYLTEEMMSSLNSVKNKPIQRKKKLAESGNTTKKPAKRARRKHNWEDEDSEKDSNESGSDIALTDDDTKEKRRGPTRKARPNGKRIHDSDEDEDEDEDEENDENMSVESVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP9</accession>
    <name>I4YHP9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956169.1">
        <property type="nucleotide sequence ID" value="XM_006956107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP9"/>
    <dbReference type="FunCoup" id="I4YHP9">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP9"/>
    <dbReference type="GeneID" id="18473236"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59230"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="InParanoid" id="I4YHP9"/>
    <dbReference type="OMA" id="GLMFFTR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="22634" checksum="E0751953B4E990D4" modified="2012-09-05" version="1">MSNPQAESNFRQSLGAFRWSQTSQSDQQPTSIWSRIQNTVSDYVPLNSEERTNEEEAYFALNRWERFLGFIICLLGSAACFVLAFLLFLPILPIRPHKFALAFSMGSVLVMAAFALLVGPWNHLKHLLSKERLVFSISYLSSLSLTIYFAVFAKSYIGVLVAGLVQVAALLTYIFQYFPGGLTTLKFGSRMAFRGASNLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW8</accession>
    <name>I4YHW8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Met22p</name>
        <name evidence="11" type="ORF">WALSEDRAFT_27060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956236.1">
        <property type="nucleotide sequence ID" value="XM_006956174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW8"/>
    <dbReference type="FunCoup" id="I4YHW8">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHW8"/>
    <dbReference type="GeneID" id="18470975"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27060"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_2_1_1"/>
    <dbReference type="InParanoid" id="I4YHW8"/>
    <dbReference type="OMA" id="MSYQQER"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="351" mass="37682" checksum="ADB83321F22498B7" modified="2012-09-05" version="1">MSLVQEKQIAITVVSRAANLAQSVFKKLVNAETVTKKDKSPVTVADYSCQSLISLLLSKAYPNDPIVGEEDAKDLRQPTDESKQLKNRVVDLVNAELSKPQAAGEADDLELGVTRSETELLDAIDRGTFEGSAKGRMWCLDPIDGTKGFLRGGQYAVCLALLIEGKVELGVIACPNLPVDPSKPDGPRGVVFGAIKGQGAFQRPISETNGPLSKISMNSITKESIAQASFCESVESGHSSQGDSANIAKELNITKEPVRMDSQAKYCSISRGDGDIYLRLPVSASYEEKIWDHAPGRLLVAEAGGKVTDIHNKDLDFSLGRTLKNNKGVIVAHESIHGDVIKAVQKVLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW9</accession>
    <name>I4YHW9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_27061</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956237.1">
        <property type="nucleotide sequence ID" value="XM_006956175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW9"/>
    <dbReference type="FunCoup" id="I4YHW9">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHW9"/>
    <dbReference type="GeneID" id="18470976"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27061"/>
    <dbReference type="eggNOG" id="KOG0210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_1_1"/>
    <dbReference type="InParanoid" id="I4YHW9"/>
    <dbReference type="OMA" id="IAITTWH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
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    <sequence length="1025" mass="115076" checksum="373EE814D5C149CC" modified="2012-09-05" version="1">MDDISDSDYRRIQLNSPSKTKYSANIVKNQKYNLISFIPYVLYEQFKFFFNLYFLLVALSQFIPPLKIGFISTYIAPLAFVLCVTISKEAYDDYLRQQRDKEVNSSLYSVINPNPSASLESGDTQAIKLTPSSRIKVGDLLLLEKNQRIPADLVLLRCTDSTGTCFVRTDQLDGETDWKLRVAVPSTQSLESDSDLLHVKAEFLAGPPIKDIHTFKGSVHHHGSSIFEQALPTEPLSAENCLWANTVLAAGSAVGVVVYTGKETRAVMNTSNPKSKVGLLDWEINRLAKILCLVTFLLSVALVALNGFRGQWYIYIFRFLILFSSIIPISLRVNLDMGKTAYSKQIMKDKNIPGTVVRTSTLPEELGRISYLLSDKTGTLTQNEMIMRKLHMGTMSFSNDSMDEIRYQLATFYGAADDDDSKAPTLVTGVQLASRGRRDMSSRVKDVVMGLSLCHNVTPVSNDDGSVSYQASSPDEVAIVNWTESVGMTLVQRDRNQITLRTPSNALLKFEVLQLFPFTSESKRMSIIVRDTETGEITFYEKGADVVMIPRVQRQDWLEEETGNMAREGLRTLVMAQRILTENTYATFEKAYNEAKVNSSIGRLDVTPEEVVDKYLEHDLELLGLTGVEDKLQEDVKSTLELLRNAGLKIWMLTGDKIETATCIAISSKLVYRNQYIHQIAKAKTVEEMKDHLDFLQSKPDSCLVIDGDSLNLCLNNLKPEFIQVATQLSVVVACRCSPTQKADIAKLIRAHTKKRVCCIGDGGNDVSMIQAADVGVGIVGKEGKQASLAADFSVNQFSFLTRLLVWHGRNSYKRSAKLAQFVIHRGLIISIIQAVFSAIMYFAPIAIYQGWLMVGYSTIYTMAPVFSLVFDRDVNEELALLYPELYKELTKGRSLSFKTFFTWMMVSVYQGGAIMIMSLLLFENEFLNIVAISFTSLIVNELIMVALEITTWHLYMVIAEIVTLIIYILSMVLLPEYFDLSFVFSLRFVWKVAVIVAVSSLPLYVYKAVRSRFAPANYAKLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI09</accession>
    <name>I4YI09_WALMC</name>
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        <submittedName>
            <fullName evidence="9">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_56165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphate transmembrane transporter activity"/>
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        <property type="term" value="P:phosphate ion transport"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cit_transptr-like_dom"/>
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        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
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    <proteinExistence type="predicted"/>
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            <begin position="412"/>
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        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="875" mass="97556" checksum="830DF356B4B8D29B" modified="2012-09-05" version="1">MKFSQSLNINLVPEWSDHYIAYSQLKKKIYQIEKDLTHTYNDRDIEAPLLSYTNNDDDSPAIKLFAPMLEKEVERISSFYKEKEIELDNDRQKLFDSIKRLEFDAFTNANGDINDMSPSRHAEHDDEDDDNDPNDNSDSDEDEDEITKQTRQDLELPSASSIHVDPQQYNDHTRHETDIREAHYKAPFSPGHSRAKTAGHPSTRRSFNGNSNEDDVQNDVPRRKSIGVIRRPSLGIFRSRTNDVDDDEVESIWTSRSNYAIDQRIMIKRRLTEVFVQFSELKQYAEINKTGFKKILKKFDKITDNELQSAFMDSVVNVAYPFTDDSRRRIENVLNQFVEVYARVVTLNNRAVAQNQLKAHLREYVVLERNSVWRQMVGQERRSQGVQIQSMYSGDEEKKLPTGIAKYIPSWLTGRLVAFITAVVVFITLTNLNMFDKGEENCLALLVFCVILWSSEAIPLFVTSLSVPLFIVILRVVKYPDGHRMAAEDAAKYILSQMMNPTIFLLIGGFTIAAALSKHGIDRVLAIRILNLAGTDPKLVLLAQMGVACFSAMWISNVAAPVLCYSLSKPLLRKLPPKSPYAKSMIIGIALAANIGGQASPIASPQNVIALDAMDPPLDWLQWFVIALPVASVTLVLIWGLLLLTYGSGKGTVITMLKPSKDRFTYKQWYITIVTITTIILWCVAHSLQGVIGDMGIIAILPLIAFFGTGILSPHDFNSFPWTIVYLAMGGIALGKGVMSSGLLDSADDAVKEMVNGFGVWRILVIFSVLATIVATFISHTIAAVLLVPIATQVGQNLNPPHGRLLIMATALICSAGMGLPVSGFPNIAAINQEDTMGERYLNTNDFLLNGVPATILAAAVVDTLGFLIMKLMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIH3</accession>
    <name>I4YIH3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956428.1">
        <property type="nucleotide sequence ID" value="XM_006956366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIH3"/>
    <dbReference type="FunCoup" id="I4YIH3">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIH3"/>
    <dbReference type="GeneID" id="18473329"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59392"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="I4YIH3"/>
    <dbReference type="OMA" id="RSMIDHA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="256" mass="28396" checksum="9682B1A86EDEAA41" modified="2012-09-05" version="1">MFLTRSEYDRGVSTFSPEGRLYQVEYAIEAIKLGSTAVGIATKHGVVLGVEKRSQSPLLLSTSIEKILSIDSHLGCAMSGLTADARTMVDHARVVGQNHRFSYDEPLLVESCAQSVCDLALRFGEGVDEDENEEAMMSRPFGVSLLLAGIDERGPQLYHTDPSGTFMRYDAKAIGSGSEAAQTELLDKYHKNLTLEEAQVLVLSVLKQVMEERLDEHNVQLAQVTTEESFRIINRDELQNAILRLPNQQPTQEPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL7</accession>
    <name>I4YIL7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956472.1">
        <property type="nucleotide sequence ID" value="XM_006956410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIL7"/>
    <dbReference type="FunCoup" id="I4YIL7">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIL7"/>
    <dbReference type="GeneID" id="18472793"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56301"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIL7"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000079">
        <property type="entry name" value="Ubiquitin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="298"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="342" mass="35950" checksum="ADFB5558BDDB8E94" modified="2012-09-05" version="1">MSLSFVIRASNDTKIPIEINAEKTVLELKEQIQSINSDYPADRLRLIYSGKVLKDEQQLSTYNIASGNTVHLVKGAPKAPSAPTPAPSTPENNGVPSTLATGAGAHDSLIEQLGSTRVAGALSQQGVDLTSPTMMEDLMNSPGFSESLSRMMSDPAMLDQVLSSPQFASLPPERREHMRQTMQSPFFRQMMSNPETLRMMMQMQRSMGGGPPGGGQSFPPPGALGQPPNQQQQEEQQSQSQENPLAGLQNLQNMLGGAGAGGLGGLGGLGGLGGLGGLGGLGGFGGFGAQPQSSDSRPPEERFETQLSQLAGMGFTDAQKNIRALMATGGDVNAAVEYLFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-03-27" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIS9</accession>
    <name>I4YIS9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955715.1">
        <property type="nucleotide sequence ID" value="XM_006955653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIS9"/>
    <dbReference type="GeneID" id="18475145"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66766"/>
    <dbReference type="HOGENOM" id="CLU_906747_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIS9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="36306" checksum="9C47D9F8AED82DE8" modified="2012-09-05" version="1">MYFISYFLTIKMSDASDESNIIHTTKTEKLSKINKNWKSLQLPNKIAIKKMLVEAQLSTDPSKKQTKYVAQLNKTHAKITKRIEQRLDHCKVPPPPANLKNKDGKRVNPGFCFDNEYRTITERLAQNLESIVLPQERIVQNLRDQLSQQRDELEFDEARFIEYTRNANKLNKHLDELEQEKLHPRLKNSFLKSHERTAQDMYIHQCAQNWNIPPVIYDSEHQKLAYNPYVDKNVRKLTQKLQPVMDKLEADAREMNPTRRAATELRDVLANAYFKHYSQRRERERKLSEGNWEDMDVDDFSSTSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX2</accession>
    <name>I4YIX2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitronate monooxygenase family. NMO class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955755.1">
        <property type="nucleotide sequence ID" value="XM_006955693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX2"/>
    <dbReference type="GeneID" id="18473118"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59004"/>
    <dbReference type="eggNOG" id="ENOG502QQW7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_5_1_1"/>
    <dbReference type="InParanoid" id="I4YIX2"/>
    <dbReference type="OMA" id="NLFCHAP"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42747">
        <property type="entry name" value="NITRONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42747:SF3">
        <property type="entry name" value="NITRONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="343" mass="37193" checksum="5FFDCB90795E802A" modified="2012-09-05" version="1">MTFRKLLQSVKLPIIQAPMAGVNTPQMAISACNSGIVGSIGCGMMEPASIKGSIEKIRNGTEKPFNINLFIVDNLDGYQPDRVAIKWLDDVYAERGLELPNPSKFAPKFEDQFAVLLEQAPPIASFAFGILDGPQVRNLHDRKIAVVGAATSLEEALQWESVGADACVIQGIEAGGHRCSFINTDDPGQPLLELLESVRNHLNIPLIAAGGLMNGGDVQAALSAGADYAQLGTVFLTTDESPIPQAYRDALYSSKGEDTTLTKGFSGRLARGIRNKFINQSSHQYSFPYPVQNAFTQPLRKDAAQRNSSDDLSMWSGKGVEAVKDSPSIESLVTRLEEEYYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ95</accession>
    <name>I4YJ95_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955869.1">
        <property type="nucleotide sequence ID" value="XM_006955807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ95"/>
    <dbReference type="FunCoup" id="I4YJ95">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ95"/>
    <dbReference type="GeneID" id="18473153"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59064"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJ95"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="94"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="289"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="450" mass="50463" checksum="712BBD875E895E72" modified="2012-09-05" version="1">MSQEEGWINESTKPADNLADRISGLSTEQQKADKPEQEELEVSVTLADQQADPNSPLYSAKTFEELGLHENLLKGIYAMKFQKPSKIQERALPLLLQNPPRNMIAQSQSGTGKTAAFALAILSRIDYASPNPQAVVLSPSRELARQTMSVIQQMGQFTNVQTAFAIKDAIPKNEKVQAQVIVATPGALVDAVRKNQINVKEVKIFVLDEADNMLDQHSMGDQSIKAKNLITSKPQILLFSATFPDVVRNFAAKFAPGANEIRLKQEELSVEGIKQFYMDCKDVEHKYQVLVELYELMTVGQSIIFVHRRDTADEIARRMTAEGHTVVSLHGKQESGDRDLTIDSFREGKTKVLITTNVIARGIDIMQVNMVINYDMPKNATGKPDSETYLHRIGRTGRFGRKGIAVNFIHDRQSWQDMHDIEVALKKPIIRVETSDFDEMEAIIKKELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC0</accession>
    <name>I4YJC0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_26776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955890.1">
        <property type="nucleotide sequence ID" value="XM_006955828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC0"/>
    <dbReference type="GeneID" id="18470952"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26776"/>
    <dbReference type="HOGENOM" id="CLU_1817295_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJC0"/>
    <dbReference type="OMA" id="IERHIPN"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="16242" checksum="0B44C9FEA4B8EFAC" modified="2012-09-05" version="1">MRTRQRSHWTRIANEFGAITQSLTLDISLNVCQARLSARVDHPTLHDPVQAIKVMHSFKNTYVPVSNLETSIENALSITEKDALFDSYDPSRDDLSPDALHDLIDRLKNAPHPPQPVFKPKVSRKPSIKKTDKDIRTFFRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJN8</accession>
    <name>I4YJN8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Vps34p</name>
        <name evidence="10" type="ORF">WALSEDRAFT_56006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956001.1">
        <property type="nucleotide sequence ID" value="XM_006955939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJN8"/>
    <dbReference type="FunCoup" id="I4YJN8">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJN8"/>
    <dbReference type="GeneID" id="18472761"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56006"/>
    <dbReference type="eggNOG" id="KOG0906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004869_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJN8"/>
    <dbReference type="OMA" id="LHKFAQY"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="379"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="663" mass="76088" checksum="2228D6FD6FC41F30" modified="2012-09-05" version="1">MQSLGWLDTLSLNNIQQLHKSAKVNENDVYLYLQLPQFDFPIVYHEIEHRIPSMIEKNIQPFNPISQLEAGNNGATAISEPLASSIVDPDGDRENPVEAKYRRLIRSHRSGLLDRELKPNPKIRDDLNVIINYPPTKELSQSEKNLIWKFRFYLARDKRALTKFLKSVTWTDTSEVHQAVDILLPLWTEPDTEDALELLGPGFVNPKVRSYGVHLLSRADDEEILLYLLQLVQALKFEISKHKHSDNFKSHQYDSGLVDLLIKRAVSNDVLGNNFYWYLMVECSGSRYGKLYARVAHLYLQNLVQTPDGPDKRETIKKQAELVETLNKIAKKLRSSKDPRPKKIETLRHIINDSRKKLSTLSIPLPIPVDSRIKVKGIDADQSSVFKSNLFPMLLYFQEDGNEDAYYPVIFKDGDDLRQDQLVVQLFTLMDRLLRKENLDLRLKLFKVLATDTTAGMVQYIPNKTLSTAVNDHGNLLSYLRYHHPNESSLMTYGVEPAILDNFVRSCAGYCVMTFLLGVGDRHLDNLLLCPDGHFFHVDFGYILGRDPKPFPPLLKISKEMVDGMGGPTSPHYHKFKNLCFTAYTTLRKNSNLILNLIALMINANIPDIQIEPDKAVLKVQEKFRLDLSEEDAIKHFEALLNETSYLSAVFDQIHNIAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJU9</accession>
    <name>I4YJU9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_12050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955645.1">
        <property type="nucleotide sequence ID" value="XM_006955583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJU9"/>
    <dbReference type="STRING" id="671144.I4YJU9"/>
    <dbReference type="GeneID" id="18470597"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_12050"/>
    <dbReference type="HOGENOM" id="CLU_1334759_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJU9"/>
    <dbReference type="OMA" id="TDFRRMW"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000044">
        <property type="entry name" value="Transcription elongation regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="206" mass="24570" checksum="E8D57D785159338E" modified="2012-09-05" version="1" fragment="single">AAAARAAMEEERQHSKNIMLAEQAEQREAEEERRRAYEEKKAAEAEANYDHEEAKALFKSMLMEYDINPLIPWDMALPTFVNDSRYTSLRNTEDRQDTFDEYCREKSMMAKKNAVTVDPVITYRELLRTEVTSTRTRFEDFKRDFKKDRRFFGYGRDDKEREKVFKSWLRELGEAKRKEAQKAEEAFKKLLRDTSEITTETDYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJV3</accession>
    <name>I4YJV3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_30945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956061.1">
        <property type="nucleotide sequence ID" value="XM_006955999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJV3"/>
    <dbReference type="FunCoup" id="I4YJV3">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJV3"/>
    <dbReference type="GeneID" id="18471216"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30945"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="InParanoid" id="I4YJV3"/>
    <dbReference type="OMA" id="NWAVGIP"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM24245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="31146" checksum="7FD5D1764A9A7C02" modified="2012-09-05" version="1">MAEEIKDAKAATKSSIKSFLSGGFGGSMAVLVGHPFDLTKVRLQTAAPGQYKGAIDVVKQSIARDGPRGLYKGVLPPLVGVTPIFALSFWSYDLGKKIVFGSRSEASNKERGSTLTTGELAFAGFFSAVPTTLVTAPVERVKVIQQTESKKAGMGTILGRIYKEAGLKSVYRGTGATLARDGPGSAAYFVSYEQIKKMLTPKDAKDLNLGAVLTAGGLAGVAMWSFAIPPDVIKSRIQSAPEGMYKGFFDCALKTVKADGATALFKGFGPAMARAFPANAATFLGVELSAKALESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW4</accession>
    <name>I4YJW4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_34904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956072.1">
        <property type="nucleotide sequence ID" value="XM_006956010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW4"/>
    <dbReference type="STRING" id="671144.I4YJW4"/>
    <dbReference type="GeneID" id="18471891"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34904"/>
    <dbReference type="eggNOG" id="ENOG502S5Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163540_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJW4"/>
    <dbReference type="OMA" id="NGCCAVM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM24256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="9090" checksum="A3422B21BA99E3F1" modified="2012-09-05" version="1">MSGRPHKQSMSELKLRRLNEHNQRLKDDYARPRINVSEASQGLIRYCKSTKDHLIPSIWGPVDKREDPYAPQGGGCCVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK17</accession>
    <name>I4YK17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_62127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956121.1">
        <property type="nucleotide sequence ID" value="XM_006956059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK17"/>
    <dbReference type="STRING" id="671144.I4YK17"/>
    <dbReference type="GeneID" id="18474712"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62127"/>
    <dbReference type="eggNOG" id="ENOG502SCI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1526359_0_0_1"/>
    <dbReference type="InParanoid" id="I4YK17"/>
    <dbReference type="OMA" id="HEERYIE"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="174" mass="19790" checksum="3EDE3D126FE64ADC" modified="2012-09-05" version="1">MEAKLKALKVGDLKELLQKANLPVVGKKEELIQRILQNESAQPKEDNAEETKENTVEEKKEEAAPVATTESKQESKQVEQEKPSDTNKDAEWEKKKARAERFGQTTEQFEKQQKKLEEKAKIEARAARFGTANSTNATKSTQAPALDPEEEEKRKKREAKFGVVEKPSQKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y592</accession>
    <name>I4Y592_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Urease</fullName>
            <ecNumber evidence="3 11">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_34262</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="JH668258">
        <property type="protein sequence ID" value="EIM19134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960830.1">
        <property type="nucleotide sequence ID" value="XM_006960768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y592"/>
    <dbReference type="FunCoup" id="I4Y592">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y592"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="18471847"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34262"/>
    <dbReference type="eggNOG" id="ENOG502QPKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y592"/>
    <dbReference type="OMA" id="DTMDGVH"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="401"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="842" mass="90942" checksum="94AC3DEC6D7E6929" modified="2012-09-05" version="1">MRLFPHEHHKVQMNALGVLAQRRLARGQCLNETEAIALISTVIHELIRDGESSVAKLMTLGKNMLGRRHVTPDVPFRIKELQVEGTFPDGTFLVTIHQPISTQDGNLELALYASFFPVPSNDLFPPHPAELYAPDKQPGAIVTKLGTPDVMINKNRKKIELKVTNLGDRPVQVGSHYHFVEVNKELEFDRIKAYGKRLDLLAGTAIRFEPGASITVALVEIGGHKYISGGSNLATGVYDKAETHRIYQNVKAAGFAHKEDINARETFSSGTPFSREIYVSIFGPTTGDKVRLADTDLWIEVEHDMTHYGDECKFGGGKVLREGMGQATGRGDSETLDTVITNALIVDWTGIYKADIGIKAGFIKAIGKAGNPDVMNGVTDDMIVGVNTEVIAGEGNIVVAGAQDVHVHFISPDLCKQALGTGITTLIGGGTGGPAAGTTATTCTPGANHIENIFSATDGIALNVAFTGKGNDSGTQGLIDVIEAGAAGLKLHEDWGATPAAIDNCLSIADKYDIQVNIHTDTLNESGFVESTIEAFKGRTIHTYHTEGAGGGHAPDIIVVCEQNNVLPSSTNPTRPFCKNTLDEHLDMVMVCHHLDKNVPEDVAFADSRIRGETVAAEDVLHDTGAISMISSDSQAMGRIGEVVSRTWRTAHKMKSLTGHLEGADAENKNDNERVKRYVSKLNINPAITHGISHVVGDIQPGKLADLVMYQPQNFGVKPEIVIKGGYIAWAAVGEANASIPTVEPIISYEMFGALHKAASKNSFNFVSEISLKNGKYDSYKLDKRALAVKKCRDVSKQDMKHNSTTPKMEVDPESYEVKADGVLCTVPPSDVLPMTKQFNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5L6</accession>
    <name>I4Y5L6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960653.1">
        <property type="nucleotide sequence ID" value="XM_006960591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5L6"/>
    <dbReference type="FunCoup" id="I4Y5L6">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5L6"/>
    <dbReference type="GeneID" id="18474592"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61539"/>
    <dbReference type="eggNOG" id="KOG1723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089419_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5L6"/>
    <dbReference type="OMA" id="TCYFCSG"/>
    <dbReference type="OrthoDB" id="3356585at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="178" mass="20344" checksum="CFEF9FB857597269" modified="2012-09-05" version="1">MRIEHCYFCSGNVYPGHGTAFVRNDSKYFRFCSSKCHKNFKMKRNPRKLRWTKAFRKAAGKEMTIDSTLEFEKRRHVPVRYNRQLVAATLKAMNRVGEIRKRREVAFWKNRMAANSQRRKLADKKEVSKSINLLPGIKASAKAAASAQTVKQKVKVPAKRSNLASAGGSGQKMSMDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y621</accession>
    <name>I4Y621_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_49106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960563.1">
        <property type="nucleotide sequence ID" value="XM_006960501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y621"/>
    <dbReference type="FunCoup" id="I4Y621">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y621"/>
    <dbReference type="GeneID" id="18472483"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49106"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_8_1"/>
    <dbReference type="InParanoid" id="I4Y621"/>
    <dbReference type="OMA" id="QSCNHPD"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="111"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="602"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88827" checksum="EDE9008644453EDC" modified="2012-09-05" version="1">MRVNPAPNGWSAPSKLFNRPPQPLQSRVILEQQQAPRLAQVGYQQPPQAHNEEKLTSGEAQKQLNDLVQGVNADFADVDLSQAQDNKVDGMSDLTLLKHQITGIAWMKDRESGVKNKYGGILADDMGLGKTIQTLAVIIGNKPSEETRKNYGKTTLIVAPLAVVSQWESEAKSKCDNIRVLTHHGPSRTRDATKFKDYDIVVTSYQIVSSEHKVWQEQGENTNKKEDKDGFVKKTKSTKKPLCALFETNFYRIVLDEAQNIKGKTSKMSLACAALNARLRWCLTGTPIQNNVDELYALLRFLKIQPFSDWDEFKARIVVPLKGGRVKVAIQRLQVILKLIMLRRTKASANEDGTPLLKLPAKHILDISCDFDKEERQFYENVHNRAEQQISKFVTDGNINSRYTSVLTMLLRLRQACCHPQLVTKAYTADDFVSNDINTTSNKDVEEEQDQQAADDLADLFAGMGMDESKKGVRGVDEDLNIKKSNKSALDELVDSAKIRAIMRILSDIHNGSQDISPVSKEKEEKRVEKKEVQKKESKPVRLDPAGRPSKAIQLSDSEDDDLDAIIKRTASMDIKKANDSSKPSKKKSNSRIVMSSDDEDEVIPTLKATESKSTSVRKKGPKPDSANAEKTIIFSQFTTFLDIIERFVKHAGYKYVRYDGTLNPTERGAVLDRIRSDDKTTVILISFKAGSTGLNLNVCSRVILADMWWNPALEDQAFDRAHRLGQKREVHIYKLTVGQTVEDRILELQKKKRELADAALSGKAVSNKLGLNEMLDLFRRDDQQDNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y632</accession>
    <name>I4Y632_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_58772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960574.1">
        <property type="nucleotide sequence ID" value="XM_006960512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y632"/>
    <dbReference type="FunCoup" id="I4Y632">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y632"/>
    <dbReference type="GeneID" id="18473062"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58772"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872098_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y632"/>
    <dbReference type="OMA" id="HYILREN"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="35595" checksum="27D75A2E915D7313" modified="2012-09-05" version="1">MTSQKRDILELDDDNLSEILSRSPTPDGQYDESIPTEQVTPAGMPDWGPVVSCLWDDCFIVFGDQHLLIEHITNDHIGQRPNGKYTCEWQSCSRKGKNQSSRFALIAHLRSHTADKPFICQEKAECDRSFTRSDALAKHMKMQHHVETLPSGKTVPLPPSERKKKQKLEDGAPDDSQDVTEPDQSIKEDESAYIDLIDESIFQSIPDDPNQPFYLPQYTYASAQYHLIEENNEILKQHLDYESQTLEKLDKENDKLLSELMSIEVNEKASNDFFKELTIKNTKKSLKSNNNHYRSGAHVVYHEIQTEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y642</accession>
    <name>I4Y642_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960584.1">
        <property type="nucleotide sequence ID" value="XM_006960522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y642"/>
    <dbReference type="STRING" id="671144.I4Y642"/>
    <dbReference type="GeneID" id="18473063"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58778"/>
    <dbReference type="HOGENOM" id="CLU_393398_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y642"/>
    <dbReference type="OMA" id="RRTEYLM"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="701" mass="79456" checksum="9B6F1C39602651C5" modified="2012-09-05" version="1">MEDSDNKRNKMDNEKKPTRSTKACLECRSMKSRCNGDGTNTCERCLKRGVACVYEQTVRRRGKDKRPRIVTRRNKSKSKSDSFDEPVTKRPRTSLSTSTSSSFDEQQYTHSPQSSTPVLSTAARPPLTSHSRQHSNDLFNSVTTPAFLSPNTQFAHFTQFAPPSPQFLISPNTSYERETFWDLLVNDRCNVNQSKDRTKVNKSISDDLWLVFSRCDFIATLFNISNFFDNINDSARRVNVEPSLIHSLLAISHALQGQFQIAYVMADRAHSTLRSAMMTGRLTVGIAQSAVVGSAFCDCTQTDLTQVLQYYESFPLGTFNIKRLAAPLYAADAVIKNLALTCLDADKVAHVFDDDGIPISTTEQEVINFNDMHLQPPLHSTEDSSTCPCQSWAQPSHVTRKDDAIRFRHIPKFATENVSESHIHQEEIRRVVWGTVNNGWYLQMLDPHAVATLHTSQSSNYGVFYTAESFVLSLPEEGLRRWSRYTLWAFVDRLKLLCHAATRLSRSLPPLELHMRANKISAEVDKIERDLANLHSCNRGVHGWHVSNVAFITRLILTAKTRQFSHPDGTNTGPSDYYTRQRAREWLDAHSLIWDHIINKQSIANQPMIFVALICQALRCLDLVALDSAFTRAIHVARNILKGIEEMIAIYPTSESSDLDKMMTKVKVSCDELEKRTILAQCQPNDSIILQNIQYIKNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y651</accession>
    <name>I4Y651_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_34015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960475.1">
        <property type="nucleotide sequence ID" value="XM_006960413.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y651"/>
    <dbReference type="GeneID" id="18471793"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34015"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y651"/>
    <dbReference type="OMA" id="LWDNQAF"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="605"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1581"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2041"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2041"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2067"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2087"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2112" mass="238617" checksum="DE6922A6AF7F758E" modified="2012-09-05" version="1" fragment="single">MTWSPLEQIAYGFCIFPFNPADGDQKSNPHQIQLETGDEIYAFEQIREPGQPIWYRGYVVSTSRYPLSTQTSSNISQNPTTIEEPQVSIGIFPSTHVRIRQMLPDAEGRLASTYVSFQSTAKQFPQRAAAAAISRTPSFGKMETLEEEEEEEEDLDKATSHLDFNDYTQYDHKLNKPEKKVPDNRPPPPLPSLKCGDETSFGHDEPLIDEIACALREYFTALHASLTRGNYSLFEKIKNNINALNYARMQLLQQSSTQSDNQEDLNDLRARAVERLVKANVDLGLDVIVRHPTTGALANISNDGNDVDKKAWISSIRMYAQQVELAYINSPVVHSGAPISQPSLKPLHQSRSISKLTEPLSINRNQRFSTINQQGNTSSSASDCNDFYHVYFNLRSFNASPCYVGETVELFFALYSANQGRFLTEDHVVVLDHNGLPIYRNGESVCTLFKDLSKVDVSDNLFLVCKIIRNGLLKSPLNFDDSASASSKKFLRRPFGCAVLNLGQLSTKSNKDMNEAVQYSMPIYVPSSNSGVAGENLFANLHQDIITNNVKVFDTSTRATDISVTVKSFHGAFNQMLRDHSGVLNNVFPTARLGFSDAVFPADIRNDLYCKLWSGDFTSTLTNPTSRLSLLSNNNSNTWKNIQVTVEARRKDGSRIEDCFTGGTGDKLQSVWDFTVFANNSQPTWGEMIKLTNVSAQEFLDVHLYFTVRNKSSRERENSNINKEKLKEDKDENVTEPPFAWGYLPIFNEGQAFLPDASHTLQLFKCVGDPPTTAFYLNNSTPTVTPGSKKERIFSGGSLQGNTGTGTATLGSPDNTMGVGSPSSPMENSRLRPLRDTISIRTFLCSTLFTQNPVLLKLLSWERERSYQIQSPTEIENVLSQLPFVGEPEIVKFLAETFDAIFGIMASSINEGDKFDHLLFNALVKVLAIIQDRRFNQFGTVLDVYINENFICGPASSHLMRSLQRLLAKPSDPSTAQQLHAALKVLPFLVRFIVRSRELQREKSAGLDVTSGHLEDTFKKELTNVLGGLIKLMEMSSPSSIIGTQTLALRHFAGCLPDLERIYPSEELVEHVMAFAEACRATKGKLVVYILLNYLHIARSGLFDKPGTRTILVPTLIRLVKPHLGPYDEYQHVKQKDPQHVKDSARIAWIECLRLSVTILATMLDKLHTAIVDPAISASRTLSRQEQDNVEDIMSLLPRLLESYHELNSDASYEAINKHNSPSTTVASIPTVFPATYPFSLLSELPSSLNSNSGKSSISLARNNHFNCGLGEIASVILVIIQLLPQKRILDFIQEHSEIEGEKNLTRFLTNIFSFSIGVLDHKDSGIDEKLIPCPYPPSWLNISIFAHRMVLKLAESVSVVMEKQFVPSIDFANEFNRNLWRVCFEMYIRLLASNQLIIEEHTPQKRRAVWKLAGDLRGEGAQTFTKLWNAIGWPDSSTGLTRYGGFQIQFPDLVADLLELCLSHHDELRNHAVGILHSMIISEHHLNGQFRAIEAEIIDKLDKLFMDGTKGDEISRAFFVSELRSLFNTSTTDETLKKDVSRFLDSVDYFLELLLSIRHLPDSQEFEDDRLEATLKLMTFIKSLREEIYVKYLHALVHMHLRSHSYAEAGMTIKLHADMYQWDSSAMLEALPDLSLPKQSHFQRRETLLAHCMEYLAAGKAFEIAIDICKDLTYQYEFKTYEYHKLADILTYQASLVDAIMKCDREFPEYFIVGYYGGFPPALKNKQFVYRGLEFEQLETFSSRMQEKHPSAKILSAGHFVSQDVVDDSEQYLFITSVSPEVDKTSPIIQNPHVPEPIRKYYENTTDLFSYTQPLDKDSNSSREGIEGEWMEKTLLQCENQFPSVLRRSEIIESRTVEVSPIELALEEVEMMRQEMGVVNSKFEVQVDNRHNKKNQGKQNLRVESLSMVLNNACDIPVDAGINFYRSAYLNKKEDNPSSQRLEKSLINLALTIRRGLDLHKVMCTSEMARFHMTLEKLFMKNYSKEIALFPNEISDFNTEFSRSSSFKSFSDKQKRIRNTSTITSSSSIHTSKSNKASLSLPKLSSFKPSKQRSSTTVDLEYNPATPKSPTSSVKSWTPKLHRSRSKTDEPPRLSLGKFDEEGFSRLFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6G9</accession>
    <name>I4Y6G9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium-dependent phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_70483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960359.1">
        <property type="nucleotide sequence ID" value="XM_006960297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6G9"/>
    <dbReference type="GeneID" id="18475748"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70483"/>
    <dbReference type="eggNOG" id="ENOG502S58R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035172_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6G9"/>
    <dbReference type="OMA" id="NDHYITK"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF30">
        <property type="entry name" value="SERUM PARAOXONASE_ARYLESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01785">
        <property type="entry name" value="PARAOXONASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="353" mass="39604" checksum="D661634DE3A576A6" modified="2012-09-05" version="1">MISDLITINGFEDNTSYSPLLASCDDRFKYNTVLGIFKDSSKSGSIQLIEPYISIDGYLDASIIPLEFKGVEEDFILHPLGIESSPSNNRRIFVVNHARNNSKVEVFDIDYDLGMANHIFSIEDPLIKTPNSIVALNDNTFYVSNDHYFSLRDRSIIGKILNWLETFLRLPLGSVELVKFDENTGAVEVNHALQYIPYANGITLVGNYLAVASTNNNQVLLYSRDNLDFIRSIHLPFHVDNLSVDSRTGNLIASGHPHYPTLIKYVKSGGQSEKPQSWVVEIVLDKKQDDVEDTRNKAMVAQRRLLKGNKDDTINSILQSSGEYINSITKLEKNKDALFASGLYMDGILSCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J4</accession>
    <name>I4Y6J4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_66221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960384.1">
        <property type="nucleotide sequence ID" value="XM_006960322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J4"/>
    <dbReference type="GeneID" id="18475096"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66221"/>
    <dbReference type="eggNOG" id="ENOG502QS1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_7_0_1"/>
    <dbReference type="InParanoid" id="I4Y6J4"/>
    <dbReference type="OMA" id="EQTFFCA"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="220" mass="25282" checksum="01C1B7B1AF999299" modified="2012-09-05" version="1">MTDRAAMQKIMKENGDLGWEAVWKLTDSPPWDNGQVQPLLRHYIENNKVDLPPAKEGVRVLIPGCGKGYDAVYFGSLGYETVGLDLSPEGIRLAEEWYSKQGLNGKTSFICDDFFTCDIGQYDVVYDYTFFCALNPNKRQEYKKRMAELVKPGGLLLSIVFPIEDRPIEGEGATGPPWCVSPEYYNGLIKEEFKWLLNEYPPIEVDNRNKKRFNIFKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J7</accession>
    <name>I4Y6J7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3 15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_61403</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960387.1">
        <property type="nucleotide sequence ID" value="XM_006960325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J7"/>
    <dbReference type="FunCoup" id="I4Y6J7">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6J7"/>
    <dbReference type="GeneID" id="18474512"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61403"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="InParanoid" id="I4Y6J7"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="511"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM19589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="929" mass="103033" checksum="242EAAC5C7C2F861" modified="2012-09-05" version="1">MSNRSSSPMLFPSSPNNNNNTPTKKRENSELFLSSPGVNPDYLAAPPSSDVGGSFVNPRSSSPMNFPSSSAGTPRGSQATPTQRRGDIHSNLPPSSPSFIKSSRRQITLQNQPTSDIHRSDRTYSQGNVPNTDAQTDEHGMMRVIWGTNVQISDSMAAFRAFLRGFKTKYRRAYEREQGNQLPTLSDQASSENLLYESYLRKMRFTGQTNLNLDMNNLVSYPPSRKLYTQLQKYPQEIIPIMDQVLKDVMLELGEEDADRDEQRIGQQAWDDELGEIMSKIYKVRPFGLPSVNMRELNPSDTDKLVSIKGLVIRATSVIPDMKNAFFKCTICQHTHQVEIDRGRISEPQRCPRDICNYQGTMSLIHNRCEFADKQIVRLQETPDSVPDGQTPHTVSLCVYDELVDVTKPGDRITVTGIFRSLPVRVNPRQRSIKSLFKTFLDIVHVKRTDANRLGFDATTRPGDRTNLAGVGVGGDDELEAEMANNDENPAGTIAEEMEQKLIEVSQRPDVYEVLSRSLAPSIWEMDDIKKGVLLQMFGGTNKSIARGGGGGGPRFRGDINVLLVGDPGTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDPDSKQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSILAAANPVQSKYNVKLPITKNIDLPPTLISRFDLLYLVLDNIDEFADRKLAKHLVSMYLEDAPETVGSDILPLDVLTAYITYAKNKIQPELTAEAGEELVKCYVRLRKTGEDANSAEKRITATTRQLESMIRLAEAHARMRLSPFVELSDVVEANRLIIDAVKGSATDPTTGLVDISLLNTGFSAQSRRQNQDLKNEIIQLIDSSRSSNIKYNDIFQQISQQSSISVENTDFADAVRQLEENGDIQVVGEGSRKMLRKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y706</accession>
    <name>I4Y706_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_70412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960256.1">
        <property type="nucleotide sequence ID" value="XM_006960194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y706"/>
    <dbReference type="STRING" id="671144.I4Y706"/>
    <dbReference type="GeneID" id="18475731"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70412"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337769_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y706"/>
    <dbReference type="OMA" id="RWNLIFY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="448"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="843" mass="97313" checksum="BA12514ADC077EE9" modified="2012-09-05" version="1">MEFTKINNFNLGHNKLDSFDRNTPPSKKQKLSDNFERSTSLTLRLNALDVNNFKTPQSHQVNCYRNLAYFLGNLIDGTINDGVKIHTLQANVRDLVRIYDKSSELYTSIQREIRRGLAVLSPKSFNYERGHFIKNVVDIWNKVDNWMRIIRYVFADLDRLYAAKQATVDSLKDSIERLFKDIILSNGEVRQILLTDLSTCLGKVREPLHTLKEDNEVAISEIIESSINCNEVNQVRELFRIAKNLDWEVDTITSVYLDTMEVVIRDICHHAIKNDTHVNKIIGKICQHRLYEDTISKSIDSNFSWDNFEFIAKNYLSLTFEEIVKKGVDDIIPYTWTKSSASRNVFNYDEIPSTTYPDTGTMKSLHDIASRTDYKEELDRVLLERIYNVIKTFVSDEENDQYLIITLIGTLRELNKFYKEVYQTKSLTASYSLYKESFDRGLQFRANKPAEMIAKFLDNLLKDKRGQGDNMDKLVDGAVELFRIVKDKDMFSAFYTLALARRLVKSTTASNDNERNLISRITKVAGNDFTQNWEEMMKDVEISEELSNKFREQQTSECRLQKANIVQAARWPFKGQHLSLKLKDLADKDASEIAKQANLSQGNIVLPQWMTEELVEFTKYYEGVHAKRCLTWNHSLGEVTLSSEFETPNGEYTNKEIIMPLPASLILMVFNEKEDNEKVSYEEIQQSTGLPDGELKRMLQSLAFGKTKLLQRYKKKDGGATKKDIEPTDNFVASKIIDHPRKRFRLPIITAEVDVEESKETTAEVESARVFALQASAVRILKAKKRINVNELIHEVIGDIAKRMTLENETGLTRQIKQTIEGLIEKDYAERVEGNRNMLEYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7F9</accession>
    <name>I4Y7F9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_40662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960042.1">
        <property type="nucleotide sequence ID" value="XM_006959980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7F9"/>
    <dbReference type="STRING" id="671144.I4Y7F9"/>
    <dbReference type="GeneID" id="18472185"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40662"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y7F9"/>
    <dbReference type="OMA" id="HPSMLEK"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="249" mass="27245" checksum="83F4033DC7F8E6FB" modified="2012-09-05" version="1">MGDCCKLVGSFSKGTPKGIESTIGDLKTYIASPSHAQGDIAVLMISDVFGWQFVNNRVLADTYAEEAGVRVYLPDFFDGDHAPHNEEQSKTFDLGQFLGKHHPRQQKEVADRVARAIKSTSKVRCLVAGGYCWGAPAALSLGHEGGAADAVFFAHPSLTEDEDFEGLTKPGLFICAEHDHIFTDEKQQSARAITAKKANLEGDARIPSSWHTYLGTTHGFSVRGDENDPFTARAMRDAQKLVCNYFKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R4</accession>
    <name>I4Y7R4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_70167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959936.1">
        <property type="nucleotide sequence ID" value="XM_006959874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R4"/>
    <dbReference type="STRING" id="671144.I4Y7R4"/>
    <dbReference type="GeneID" id="18475695"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70167"/>
    <dbReference type="HOGENOM" id="CLU_1262397_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7R4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="24693" checksum="C9AB8C29CCC9993D" modified="2012-09-05" version="1">MQTKTPDDIYNNFKTQAREAKLAKAREKEEAERRSLEEAKRKAEIDMPPPFIAYYHKGGGCSTGRSCAELSLDRLAFFLVMTNQRSCGFNFWNGFLAIILPPVSVAITTDCQNNGVVHVLLNIVLWSCLILPGIIHAFWVLLKWDERLLQKQSPEVIYVQQAPTNQQSITPIQQAQSSPAHKAVQQHPPDAETSPSGHKNPQKQDQLPNYNDSQREAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7S1</accession>
    <name>I4Y7S1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid phosphatase/Vanadium-dependent haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959943.1">
        <property type="nucleotide sequence ID" value="XM_006959881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7S1"/>
    <dbReference type="FunCoup" id="I4Y7S1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7S1"/>
    <dbReference type="GeneID" id="18474377"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61183"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y7S1"/>
    <dbReference type="OMA" id="WFSYRRY"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="339" mass="38552" checksum="D41E46B44776CC7D" modified="2012-09-05" version="1">MIKIDLSRPPSILPKFLQHPYARRTNIDHPIVTSKWKLVASYGMDWIICAILLGLLYLINNVHGYWREFDVNDVTIRHTYATEERVPMTLLGIIIGLIPLVCLVVLSTQWYRSYTDLHHSILGFLLTISLTISTTTSIKVLAGRMRPDFIDRCQPTAGSVNADVGLSTAAICTQTDFNILQDGFRSFPSGHSSSSFALLGYFSFYLAGKMQIFDTKGHTIKSWICWTPWIGAVLIAVSRTMDYRHHATDVIAGAIIGSFFAYVCYRQYYPHLGEPLSHKPHNSRYIEANDAYRLPTHQTEGYGLERVTNEPQLPQQSHTINHARDRLDEVHLNEHKYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W3</accession>
    <name>I4Y7W3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959984.1">
        <property type="nucleotide sequence ID" value="XM_006959922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W3"/>
    <dbReference type="GeneID" id="18474399"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61218"/>
    <dbReference type="HOGENOM" id="CLU_1751114_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7W3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="149" mass="16858" checksum="606B8BA008D8D784" modified="2012-09-05" version="1">MGQSKFKPRQTMSRINKPAPIKHSGDNNLPPVDHRRSGLSRPTTKNVLLRNQLAPKKTLAIHKTLKTHVENIKAIYEASVEVDDPEILKCFNFSKETTKILLLFGDGRLDALMERLAHGDNLNHDNNTTNADEEDYITDDDECYSDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y853</accession>
    <name>I4Y853_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959866.1">
        <property type="nucleotide sequence ID" value="XM_006959804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y853"/>
    <dbReference type="FunCoup" id="I4Y853">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y853"/>
    <dbReference type="GeneID" id="18471710"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33584"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_5_1"/>
    <dbReference type="InParanoid" id="I4Y853"/>
    <dbReference type="OMA" id="WYDILAM"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="231" mass="24963" checksum="2C11D3C23730BDDD" modified="2012-09-05" version="1">MALQYLTVPARSTQTASLIFVHGLGDSGYGWKPVAEFLSQSLPHVKFILPHAPSQPVTLNGGMSMPSWFDLTSLTLEGTDDEDGLLKSSSELNKLITAEVDNGIPSDRIVIGGFSQGSALSYLIGLSSERKLAGTVALSGWLPMRNKIKSMLGPHHQLLPIFQAHGSDDPVVNPKYAELTNEYIKSLGFKTVDSDKPTNGGISFNKYDGIGHGACQEELADLEIWLKKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y867</accession>
    <name>I4Y867_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_40446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959880.1">
        <property type="nucleotide sequence ID" value="XM_006959818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y867"/>
    <dbReference type="STRING" id="671144.I4Y867"/>
    <dbReference type="GeneID" id="18472173"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40446"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y867"/>
    <dbReference type="OMA" id="TPWYFNH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="57"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="397" mass="44308" checksum="04A861FF2AA65C3F" modified="2012-09-05" version="1">MIVNYEASKSVRSSKLPPIPEARLWLDEYNGNSSYNLSQGVPIDPPPLLLQQELGKQSVITTNYQYGAISGQPAFKEAFKDDLNRHYNASLSTDNILITPGANAAFYTTILALTQINDTSNIVLQSPFYFNHEMTLSQLSIDVRLLDCRADKAFVPNPKDLEAVIDTNTRAVVLVTPNNPTGVSIPSNVLEECMKICADKHIPLILDETYRSFSEFDRPHNLHTLGLNNLIQLFSFSKDLAIPGLRLGGIIAHEDFIGQCMKVADCYQISPSNISQSAIAPIYDQLNDFKLEQKLSLIEKHKTLKSLIDELGGWSITSSGAYYAFVNYPYNLSSTDVASTLARQFGILTLPGAFFTTDNHSDANNHLRISVANVTKETLLDTKQRWLDFDKYMKEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D1</accession>
    <name>I4Y8D1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_21019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959711.1">
        <property type="nucleotide sequence ID" value="XM_006959649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D1"/>
    <dbReference type="FunCoup" id="I4Y8D1">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8D1"/>
    <dbReference type="GeneID" id="18470867"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21019"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8D1"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="29864" checksum="AC252B0239944BB1" modified="2012-09-05" version="1">MSTENYTQSPPNYTTTANKTDHKNYNSISGNEEITNAGPSGDLPDDFKYGATISECVKEIRLQSVRKIYTILSLQLLATFAVGFWVSYSQAMQTFILRHPNILFVPLIGSFVTLGLTYWKRHSHPTNLALLSSFTAMEALAIGAVISTFENKTIVLQALLCTAVIFIGLTAFTFQSKYDFSGLAPILSVGIFGMIGFGLVGLFVPFSSTISLVYGILGVALFSLYVVFDTHQIFNRLSPDEYILASISLYLDFLNLFLSILRIFSSMDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D3</accession>
    <name>I4Y8D3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959713.1">
        <property type="nucleotide sequence ID" value="XM_006959651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D3"/>
    <dbReference type="FunCoup" id="I4Y8D3">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8D3"/>
    <dbReference type="GeneID" id="18474314"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61061"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061887_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8D3"/>
    <dbReference type="OMA" id="VYKWRVE"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="36951" checksum="A1FBACB13502C771" modified="2012-09-05" version="1">MRNAIRRRNHKERSQPLNRQKLGFLEKHKDYVKRARDYHSKQDRLKKLREKAELRNKDEFYFGMVGKKTQKGQHFQDRGNTPLPNDLIRVLKTQDTGYIHMQRAINNKRIDKLKSNLSSLTNIKELADEERRFDLGIDEYQEFALKAASLIPSDEPKNSRRRSRSDWKSHIVFADPNEPNVEDNQDTQEEAADNDEDETVDLGWKESKKDRKRASKAAATVTVEEDKDAIDGNDAFDDEVVGETQLKKTLNELTQRTFRQDALDRAARELELTKALMGKGAKQKLEKGQKTRIEDGEQEDREGKARVFKWRAERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8G0</accession>
    <name>I4Y8G0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_40231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959740.1">
        <property type="nucleotide sequence ID" value="XM_006959678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8G0"/>
    <dbReference type="FunCoup" id="I4Y8G0">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8G0"/>
    <dbReference type="GeneID" id="18472159"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40231"/>
    <dbReference type="eggNOG" id="KOG4624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142621_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8G0"/>
    <dbReference type="OMA" id="MLQQDGK"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="79" mass="9379" checksum="81BEC492302A2FA9" modified="2012-09-05" version="1">MRILSRREDEEIVKQHKQLGLQHCHHLVQQFAECTTNRTISVLWACRKPHKELNSCLAQFNSEEALDAAKEEYLKKRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I3</accession>
    <name>I4Y8I3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959763.1">
        <property type="nucleotide sequence ID" value="XM_006959701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I3"/>
    <dbReference type="FunCoup" id="I4Y8I3">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8I3"/>
    <dbReference type="GeneID" id="18473004"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58303"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8I3"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="266" mass="30392" checksum="45482B36614A12F2" modified="2012-09-05" version="1">MLNYNFFYKPINQQSNSISNETWSNKLNQLSLSKTHLNKLVLDYLVIEGYTDAANNFAKETGLDMTKSDIDSINERRDVKDYITIGDIHNAISTINEINPDILDQNTELYFNLQLQQLIEYIRHKEINQALEFAQTTLSQIAITIPSLLPSLESALTLLAFNSPDNEQYAQAKDAPGNIRQLLSQSQRERVANQVNTVILEDQMHSKEPKLAGICKLLSWGEDALSSRVSFPRYQPPLHKHGKSNQQNDRDMDANKYGQFDQQMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L1</accession>
    <name>I4Y8L1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_55113</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959560.1">
        <property type="nucleotide sequence ID" value="XM_006959498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L1"/>
    <dbReference type="FunCoup" id="I4Y8L1">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L1"/>
    <dbReference type="GeneID" id="18472714"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55113"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L1"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="29"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM20303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="39572" checksum="DA3433C2B7EC63E3" modified="2012-09-05" version="1">MLTINDQIAKEGKCYYNNVQHAPTDGFLGAIGNTPLIRLNRLSEEVDADIYGKAEFMNPGGSVKDRAALGLVLDAEEKGQLKSGGTVVEGTAGNTGIGLAHVCRARGYKCVIYMPNTQSSEKIDLLRMLGAEVHPVPAVAFDNPQNYNHQAKRHADSIPNAVWTNQFDNPDGNRDVHIHTTGPEIWNQTEGKVDAFTCSTGTGGTFAGVTNYLKSMNKDVSCYIADPPGSVLASYVQTKGEKMDRSGGSITEGIGQGRITANMTVDVKSADGGFTVPDSDSIAMLYRLLDEEGIYLGASSALNVAAAYKLGKDLGRKSDGSRRQIVTILCDGAYRYQSRLFSRKWLESKNLVDAIPAHLQKYIILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8P9</accession>
    <name>I4Y8P9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA isopentenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_58206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959598.1">
        <property type="nucleotide sequence ID" value="XM_006959536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8P9"/>
    <dbReference type="FunCoup" id="I4Y8P9">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8P9"/>
    <dbReference type="GeneID" id="18472994"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58206"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="InParanoid" id="I4Y8P9"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="478" mass="54541" checksum="D5509DEE6BE6F36F" modified="2012-09-05" version="1">MKKSVISVIGSTATGKSDLAVHLAKLFKGEVINADSMQVYKGLDVITNKISESDKRGVNHHLMSFLDRDKEYAIPHFMADSTSLINSMAENDILPVVAGGTHYYIHHLLFANKLIKNESPASRSLPDVPSPSYVDIISVLSENDQKLAMKLPEINEADYDASDERGVPLYARLHSILSQIDPPAASRWHIRDFRKVKRSLEIIWEHGKRRSDIENEQKAQQDDSLLQTRYKNLVFWVYTDPEVLSKRLERRVEKMTEQGLLNEIEEMRALENEFRVGGEQDYTRGIFQAIGYKEFDAYFKATNSQDRDVAFKNGLELMKIATRQYATKQLKWIQNKLIPEILAHQESAQKVGNPSSVYVYMVDSSDISQWDERVTKPASEILEKFLKDDTLPDPRSYSETANKLFAKQSLQAVSNAERGYRKVICEVCTTDPHNPVMLGEGLEYENHLRSKAHKAKTRPKATRPSDAEIARLRALKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8V2</accession>
    <name>I4Y8V2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_55154</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959650.1">
        <property type="nucleotide sequence ID" value="XM_006959588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8V2"/>
    <dbReference type="FunCoup" id="I4Y8V2">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8V2"/>
    <dbReference type="GeneID" id="18472717"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55154"/>
    <dbReference type="eggNOG" id="KOG0434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8V2"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="28"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="705"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1084" mass="124252" checksum="15D328FA6253CE72" modified="2012-09-05" version="1">MANQRETKDFGSFDITSQFSFPAEERKVLEYWQDIDAFKTQLKHSEGNPTFSFYDGPPFATGLPHYGHLLAGTVKDIVTRHASSSGFHVPRRFGWDCHGLPVEHEIDKKLGITGREDVLNMGIDKYNEECRAIVMRYSSEWRSTVERMGRWIDFENDYKTLNTSFMESVWWAFGELFKKDLVYRGLRVMPYSTACTTPLSNFEAGQAYKDVSDPAVVVSFPLLDDPKTSFLAWTTTPWTLPSNLALCVNPTHTYLKIHDEEKDANFIIHEKLLTTLYKDPKKAKFTKLDQFKGEQMKGWKYEPLFDYFVEEYKDKAFKILTDGYVSADAGTGIVHQAPAFGDDDHRIAIANGIITPDQMPPCPVDDSGKYTERVRDYVGVHVKEADKDIQKHLKAKGRLIVQSTLKHSYPFCWRSGTPLIYKAIPVWFVKVSQITDDLIKNNEETRWVPANIGENRFGNWLQNARDWNVSRNRYWGTPMPLWVSDDYQEVVAISSIQQLEELSGVSNITDIHRDKIDQITIPSKQGKGVLRRVDEVFDCWFESGSMPYAQAHYPFENKEQFEKSFPADFVSEGLDQTRGWFYTLLVLGTHILGKAPWKNLIVTGLVLAADGKKMSKSLKNYPDPNHIIEKFGADAVRMFLVNSPIVRGDNLRFREEGVKEVVSRVLLPWLNSFRFFLGQAALAKKEQGIDFKYDPSAPRSENLMDRWVLARCQSLIKLVKEEMGAYRLYTVIPRLLSLIDELTNWYIRFNRRRLKGENGKEDTVAALRTLFEALFTLCRTMSSFTPFITENLYQGLRPYLPETIQGAKDIRSVHFLPFPEVREDYFDTVIERRVSRMQNVIELGRVVREKKRIAVKTPLKTLIVFHHDKGYLDDVCQLDGYIKEELNVRELIVTSHEEYVGIKYKVSADWPVLGRKLRKDMPRVKNNLPKVTNDEAKAYIATGKMTIDGIDLQAGDLTVSHYVDLPASMEGFEAVSDPNVTIVLDHRLHPELESEGLAREFINRIQRLRKKANLIQIQDVDVVVKFESEGEDVATLQGAIEQHKEAIIKSTKSNPLSSKENPQVILSDDQEIGAVKFNLTLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Y3</accession>
    <name>I4Y8Y3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959451.1">
        <property type="nucleotide sequence ID" value="XM_006959389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Y3"/>
    <dbReference type="STRING" id="671144.I4Y8Y3"/>
    <dbReference type="GeneID" id="18474242"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60910"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8Y3"/>
    <dbReference type="OMA" id="NRRTDYP"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="290" mass="31528" checksum="BD51A058A50D0CC5" modified="2012-09-05" version="1">MSAIRCWKRLIRFVAKEDGRIYLGEPLSADIDVGLSKNIQADILNTNSALTATLRTGDIKTVSKLLSPLSFDEVPTSRFLGLNYRDHAEECKLKIPTQPILFYKPSTALAGPGDAIPIPRVCQPSDEHLVDYEAEFIAVIGRAAKNVSKKDALNYILGYSIGNDVSTRKHQFGSSQWGFSKSFDGSAPWGPALVSADEITDPQNIPIGTKLNGTIMQNSSTLKQIFSLAETIAFLSQGTTLLPGSLIWTGTPMGVGFTRNPPAYLKHGDKVEIFSNNQIGTLVNNVANDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Z1</accession>
    <name>I4Y8Z1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959459.1">
        <property type="nucleotide sequence ID" value="XM_006959397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Z1"/>
    <dbReference type="FunCoup" id="I4Y8Z1">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Z1"/>
    <dbReference type="GeneID" id="18474247"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60916"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009082_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Z1"/>
    <dbReference type="OMA" id="KMGMAGE"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="749"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="796" mass="89417" checksum="173144B5F6A3E883" modified="2012-09-05" version="1">MRIVVKGGVWKNTEDEILKAAISKYGKNQWARISSLLVRKTPKQCKARWYEWLDPSIKKTEWSKTEDEKLLHLAKLMPTQWRTIAPIVGRTATQCLERYQQLLDEAERQENEELGLTGPGDEAGPSDDVRKLKPGELDTDPETKPAKPDPIDMDEDEKEMLSEARARLANTQGKKAKRKARERQLEEARRLAVLQKRRELKAAGVISRIREKKKGVDYNADIPFEKQPAIGFYDVGEERAKTYESSIGKSRMEAEGKRKADKGEDERRKKQKTASQESNDKYQAAREAQIARLKEADKISARRKLDLPAPQVGEKELEDIVKLGQSGESTRELVEEGDTSTQGLLGNYDTIGSVHNLRTPRTEQGEDNIMSEARNLRNMTASQTPLLGEENTPLHEQQSGTGYQSATPKHVANFTPNPLATPSHGGAPGVPFKTPMRDTLSINRTDGILEAFETPAERKYSERSEKARLKTGFQNLPKPQNNFEIEMPEDEADEIAQVAAREEDAAERDARIAAALAEEERRILARRSSAIKMNLPRPVNIDVTGLLQSLSFKEKSVEEMVENEYVRLVVHDSIHYPLPGATPAHGIDPIAELPDEAVDAAKSAVDAELAASMGVPGANSDAVKRALLASIETQLDAIPSGELGYSKKAQAVVHLNELDDREKMEYYTFRFATIKDRLTNDAVKSAKQEKKLGIKLGGYMARKEALSKRLSKAFDDVETGTINREAFGLLALNEREAAPARVYKLEKEVSFMQQRERELQSRYKELEMERRRRQEVIEGLEEEEAERLNEIAMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y909</accession>
    <name>I4Y909_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF323 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959477.1">
        <property type="nucleotide sequence ID" value="XM_006959415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y909"/>
    <dbReference type="FunCoup" id="I4Y909">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y909"/>
    <dbReference type="GeneID" id="18474255"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60925"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y909"/>
    <dbReference type="OMA" id="FKHWHPT"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="118"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="530"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="677"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="85220" checksum="450EED080C3B45D3" modified="2012-09-05" version="1">MGNLNKTKNESGDVDYFALDLDRDELERTLDEMREQKLDNGVNLAGLCGTYDMGFNWLSSKLKSDTNSSTPSIDRKESIVSMSDFDPSPPRKSSLPTPPSSPGLTGDTNVGVLGDDRGPLSFWHLGSSIGNFDRTSAVSFLQTVRDSMRPGYDTLLIGLDGRNQAPIVKRAYDDEYGVTESFILNGLSHASRILAPYNDNNEQLLEGKFRYVSVYDEDKGRHEAYYKSLEDFTINVPVVNAFNEITNGVKEIDIAKDELLNVEWSYKYSDEEAIALFKAAGLRVTYKWTDSEKMYGLWLVERPPFNLLPPNLPMWASTTRHSLQGVPLIDDWLEMWKCWDCIMKMVPSDMLHRKPIDLRHIVLFYFGHIPAFLDIYISRQFGEALTNEHFKDIFERGIDPSMDDPNVCHDHSAVPENEDEWPTLEEVLEFDMKTRERLLNIYADIDLGKLHLDRRLARVLHMTYEHMIMHGETLLYMLIQKCEEINPPSGFSIPDWTALKSLWDVKAEERNQVLEFASQDVLLGHNDSESGDFDAGNKNADSHEYGWDCENPCNRVHVEGFKVDALPIRNGEYKEWLQKTGNNHLPASWALSDGEIKIRTLYGLVDFVIGQSWPVQDSLEQLEKFAVDKGGRIPTEAELKVLSNTIGNDHAGANVSFANWHPIPPAAPSETGKGHNGGVWEWSSNTFEKLEGYEASNLYPGYSSDFYDGAHYVVSGASYATAGRIAERSSFRNWYQKPYSYVFAGARVAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y983</accession>
    <name>I4Y983_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959551.1">
        <property type="nucleotide sequence ID" value="XM_006959489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y983"/>
    <dbReference type="STRING" id="671144.I4Y983"/>
    <dbReference type="GeneID" id="18471659"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33351"/>
    <dbReference type="eggNOG" id="ENOG502S7DD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950627_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y983"/>
    <dbReference type="OMA" id="TEDIDIY"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31305" checksum="D84ACAEA6E00D51A" modified="2012-09-05" version="1">MADAEDIDIYGDDLGGGDPGDIYGGLDDAPAAPVEDSRDDVKFTISDIAQPKVEDEKPKGEVLPTAITSTPVFRSEPLPYNYKPLAALMFNELHWYTKDEDLMTTIDDLGIRVRHQDIAFAEHKVNGKSKGTAYVEVANKDAAERVKRWFETHDFQDKRMQVQHTPCVNGNPFKTIPKENSGKNANLAYQNQQLSRGSFRPRGGSRPPPSNHSRPPSGGGGGGSGPPMMGMPNMMGMPMNPAMMQQMMMSGRPPLPHMAGPNNSNTSQRGPSSSEDPRLAKRARQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y990</accession>
    <name>I4Y990_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959329.1">
        <property type="nucleotide sequence ID" value="XM_006959267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y990"/>
    <dbReference type="FunCoup" id="I4Y990">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y990"/>
    <dbReference type="GeneID" id="18471631"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33189"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y990"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113286" checksum="49634F3D4CF3A0C8" modified="2012-09-05" version="1">MDLATILISSLSPDTAQRSAAEKELERLQPDAQFALALTDLIANLDNPLHTRQSAGIILRKYVNERWSPFFVAFKGSPPPPEIKDVIRQRLYALLATPHKQIRTACAYALASIASCDYPEQYPSLLHDLAQLIQQGGRDGVHGAMRVLLDFVKADLTEAQLVPITQELLPLLLQILKNPHYADSTRGLTVAVLRQCVLTLEMVKSTYPDAVKDTANKVIPVWMDAFIEVLQVPPQLESRSQWGIRFEIVKTISSVFSTFKPLITASNRIDILTRTLIDHLGSLLPIFNDIEVYDTNTYEQPDGEEDDDGATVNELICPIVDLLTGFANNKHAKSTIEQVIPVLVRLSLEWGQMTVEDEETWGSDPNAFVDDEEDETENYSLRVATHDLLGTLLDRYPSLTAQALGPVTGEMLANSQGASQEGNQYWWKPIEAALAAIGNLSNQLGDEDHPAAENFDLVGLCQSVVSQFVSAKEAPYLQGRAFVFASKFATNLPEALVDAFVEAAASILTESDAGVPVKLSAVRAIRNFAHDLDSDRIGPKALPILSSVVPLLSLTTESTLGLLVEAVDGLLSTIEKETLTTDLVVQLSSVILPVWEKNINDPLLSSQLDDLFVTLSKLSPSVHTALVNVSVSPLVSAVSRALPGQTSDDDIDARLLASSALQLINSIVGARAQGLEPSVLDSTCPALFSILEASDDRSLVQDGIELLTTFIRKDIQGLLEWNNDTLVRILNVIAKLLSTAESEGSALFIGDVIIQLFRNVPKEILDPALPQLLKVVLDRLALSKTSAFTQNLVIPFAYLIHTRREIMLDYLANTAVLDATTNQMVNGLEILLRMWSENAETFRGFWAIRISTLALVDLYTSQDPRLESIFVKGDQIFDEANKNTIMTRSKTRNQPISFTSINFPLKAVKLILNELQNAGTSAAKSNVLKDVDEDDEDDDWEDDDPLGGADDDIHFLSDLLNPGGAGLLDAFDEDDDEEDLKNDPDAQLDIAAYLSDFLRRAYTDNTFNTHERCANLTPQEQAIFQHAMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A5</accession>
    <name>I4Y9A5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959341.1">
        <property type="nucleotide sequence ID" value="XM_006959279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A5"/>
    <dbReference type="FunCoup" id="I4Y9A5">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="GeneID" id="18471633"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33197"/>
    <dbReference type="eggNOG" id="ENOG502QRFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060583_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9A5"/>
    <dbReference type="OMA" id="MATEHHI"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697637" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="33558" checksum="119BEFA1E54919A5" modified="2012-09-05" version="1">MMMKSAVILALIGAIQAHGHEDIDPDTPDNYIAQHMASEHHINGFDLVSFFKLHDLDRDDLLTGPEIEAIYGLHHYESTGNSKSDDEHSKKVEYVITEVLKSLDDNGDGVITLREFKNGGAEGLPSFPELGGLGHHYDEESEYFIHHEEKYHSTPETQTDESYNHPEDIKHFANHGHIDHDEDSKEAKFLSAQSVDHDAHDDGIQHIVDDNGNEPQELKNEIPEQEQKKPAEPLGHVSGADNLRKIHDFVTQAKNAGQSKWGDGDNGYAQPKSHTDKASRKNLPYKYRFSRPYNREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9B9</accession>
    <name>I4Y9B9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959355.1">
        <property type="nucleotide sequence ID" value="XM_006959293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9B9"/>
    <dbReference type="FunCoup" id="I4Y9B9">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9B9"/>
    <dbReference type="GeneID" id="18475626"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69713"/>
    <dbReference type="eggNOG" id="KOG3322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007205_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y9B9"/>
    <dbReference type="OMA" id="RRTMSHN"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="438"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="700" mass="79625" checksum="B1BE2521D0826E5B" modified="2012-09-05" version="1">MIANSKEKKKAKYQQARKIDTQLPSSINVEDHVKARQFEIKALFKAIDSSKTASSSRAFQTLPRHLRRRAASHNPKRVPFRLREKALAEIKGDISKFRRKRRKLLRTRMKKQQSSASRTVNLQKRQLNKSWLETHIWHAKRMKMVNIWGHRLAKHPTEKSFRPSVRASRQGCIVHDASYTALVQIDGSQERILSLLDSILDKAGESASSKRYIFGTREMHSYIYRSNSYPTEIISPISLIWHPADGVRDKRSIWLRCHPSAFKTVYESLNEAKIALSGDDLTISDLRGQVNTFEMYGPQSSQVLAGAFRLAKANGKAQRIAWQKIGKLTTPAHLPTGFVAGFNIDDPRLNYPPRNTKADKDKPVTNLTLSTTLAQSGIFSKAEREKVSKPRYKKAEIDSRRSKAQPGKPLAATPNDDVIPILVIQKKLEGGLRDSLDGYTLIVPAGWGMQIWSSLIHTDSRVGGIEQVEQFSVQVGASHFPESACPTSLANWEECQKRIEDVEERVSRKPKGKRPHYHSELPLLPFIQKPYQVEKKEDVQSEVKDGQLPTQPSEQAMDVHEDQVNTKQWFMTDELVRMVQNEIQENQKDVQDALKSVLTSLKCKDDVTLEDALVQATLVPIKRGYVSACGYVYDKDNDETCGRIATSTFAMNEGKAVAIANMQAVVYFKLYSQKKHLERIVVVQDNDDETKREYRLHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9D7</accession>
    <name>I4Y9D7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959369.1">
        <property type="nucleotide sequence ID" value="XM_006959307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9D7"/>
    <dbReference type="STRING" id="671144.I4Y9D7"/>
    <dbReference type="GeneID" id="18475632"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69732"/>
    <dbReference type="eggNOG" id="ENOG502S51F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017901_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9D7"/>
    <dbReference type="OMA" id="CTNLRSC"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="51312" checksum="A3C501ECBBD39504" modified="2012-09-05" version="1">MNNLPIELVYNLIEPLASNHDDLLPTLLINKDFSLESYKLLYSFVAFRPWQRPDKIIQYFDSIETNPRLAHLTRHLEVRSFPRQLNYNEKQLFYQKICTLLSHFKNLEICSWTRAFSLTTDILLILSKLPKLAELELNAGNQLDYDIIFNSDWNTLNTLKIILPNRDIVVPLHRFLLNRGQQLRSLVILAKESSVIDDNYIAAISKSLCNLRQLTLGGFKRVTEKGLSRILLHNNRLRSLCLESLNFSNVSWDIYLPELEHLTITFSTPETISRLLDLTRKSTKFRSFTIYSSGMQSLPYLPEEFITRLLAMHAKSLSTIRIHHVLISQDALVRLSQHCEGLTELVVHLPSIDIALILTCASKWRRLERLHLLGEPSDNDIHADSLLPLAKECKNLTQIGWRSRVWKVVRHGTDISLDLYKQIYIPSVFSVCTILSSDTPTKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K3</accession>
    <name>I4Y9K3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_39771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959428.1">
        <property type="nucleotide sequence ID" value="XM_006959366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K3"/>
    <dbReference type="FunCoup" id="I4Y9K3">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9K3"/>
    <dbReference type="GeneID" id="18472128"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39771"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9K3"/>
    <dbReference type="OMA" id="EFIIFFN"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="6">
        <location>
            <begin position="434"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="807" mass="92065" checksum="AAD1CB92E02F410A" modified="2012-09-05" version="1">MDHQLLKSLYDQKYERRKFAALELEKDLLNFLNKNELNKIKLIIDQLSNSLNKDKPINIKNGGLIGLAAAAIALNDNLNNYLDVIINPILLCFNDQDSRIRYFACESMYNIAKVSKSNLLPYFDQLFENLIKLSSDTEISVKNGSELLDRLLKDIIIDNANLINLDNYLTLIEKRIYVVSPFTRIFLISWLTIFDSISDLQILNHLSKILDGLFRYLSDNSVDVKTSSQHLLDSFLNKIVKTKFNHSQFTVDYLSISNILINHLNSTNEEIQLNSFNWLLELLNCQSNFLVPSLTPKLIPSILPFLSHNNQQINGLVKSLNFKLFDVIKNLNDLNSFDFQLTLSNLTIQLLNDLTETRVAALDWMLMLQEKSSNKIFNLQDGTFPALLKTLSDPSEHVVKRDLRLLAQVSKSSSLDYFNAFIKNLIKLFSTDRRLLEKRGSLIIRQLSLSLGSSKIYNALADILQYEDDLDFASFLVQKLTVVLITAPELADLRKRLKCFESKDDELLFCKIYKSWSHNAISIFTICLLSQHFEHASELLYIISELEVTVNLLIQIDKLVQLIESPVFIGLRLQLLEPDNNPYLYKCLYGLLMLLPQSSAFTTLKNRLNSVDSQFKTLTLHTQRKQLSSPQPSTLPWNELKDHFRSIQYRHEEARTIQMIESYSVDNDFDQNTAISTSNSENHEDPQNTRNVSSFTDFDSKSDFSKHQLNTLLHNRQSDSSDFSPSASMSSIKSRFGITPMSNKLIDKNSLSDTSGTITPYANTSGPSVAKTTYDLANADLNLNDTQRSHTSGSSSKNSLRRLSAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M0</accession>
    <name>I4Y9M0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959197.1">
        <property type="nucleotide sequence ID" value="XM_006959135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M0"/>
    <dbReference type="FunCoup" id="I4Y9M0">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9M0"/>
    <dbReference type="GeneID" id="18474162"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60786"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9M0"/>
    <dbReference type="OMA" id="FCWLVIH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="24749" checksum="34286A134527895A" modified="2012-09-05" version="1">MNAVSSQATRQINKLKEDLSKLDDENSIVSNALTGQIAASLAALNRTIDDYEQLSKGELNSAKQEKAEARCADLRRQSKSLRQHFEVSKNKASERATTTLRSDLMAGQDIRTRNQDPLFQPNRSQWDDFNMRENDFVRNADSQLDSFLAQGAHILENLRDQRSFLKGTKRRLLDAANGIGLGRTAISFIERRSAKDIIIFYIGAACTLLIMFAIWYYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9T6</accession>
    <name>I4Y9T6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959259.1">
        <property type="nucleotide sequence ID" value="XM_006959197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9T6"/>
    <dbReference type="GeneID" id="18474992"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65148"/>
    <dbReference type="HOGENOM" id="CLU_601590_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9T6"/>
    <dbReference type="OMA" id="WTHAEKE"/>
    <dbReference type="OrthoDB" id="3352666at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50956" checksum="6387750A7146EEEF" modified="2012-09-05" version="1">MKGFLDLPNEVLSQIIDNYLDLNDIYLLRICNKRLLELSRSIVLNSIQMRLFGLTAGVHTTKVIESGLFSSRNCQSVHSLSLIIGPPNNEEEEAVAKEMENSMDFADESEISELIVRLQRVQNVRLHLSNTPQWKETEKEAFQRLLYSLATLRRLKDLTILSPGGLWEAMILPPIQTLESLTIRGDIPNKAILGSCVENSRALRQLRLPNDDRETSEALEGLSSNTLPALEFYEGRSDDIVELTNENVAPNLKRLRYIPHKEGDSSLEEVQSTLSVLEGRPLSSFAYETLFTMQFNEVVNSLTPFKETLTSLAIGNTNALAPPELTLEERLIGEIRFSSAFVDNLPRLTTVCLTYATAEGMPHLPSGNSGTTTLPDGSIATYFDRVAALWFKQLPTLCGVGMIFLDGTPSKAWYATVFGIDQKGESLDVDDSWRRYQPFPEELALPAIQSWIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U2</accession>
    <name>I4Y9U2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_33155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959265.1">
        <property type="nucleotide sequence ID" value="XM_006959203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U2"/>
    <dbReference type="FunCoup" id="I4Y9U2">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9U2"/>
    <dbReference type="GeneID" id="18471628"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33155"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y9U2"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="95"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="576" mass="61544" checksum="A50B532F9C5C7A48" modified="2012-09-05" version="1">MLIQAGQLLNLNVVVLENDSNSPAKQVTNNNSEHITGSFNDPVSIKALADKVDLLTVEIEHVNVEVLEEIEKTTNVRVSPSPATIRTIQDKYIQKEHLMKHAIPVAKSIPLLEQSPEALKQTVDNELAGVYPVMLKARRQAYDGKGNYLVKSPEDAVQAVETLSKTAGSGGLYVEKLAPFVAEIAVMVVRSESGKVVAYPAVETVHEDSVCSVVFAPLQTKDSGIQQRAQDVARNAISTFTGAGVFGVEMFLLGDGQILLNEIAPRPHNSGHYTIEACATSQYANHLRAILDLPLGATDLVVPYAGMINLLGRNDGSEEGVLKLARKALEIPGAHVHLYGKAGCRKGRKMGHITVVGESSAAVHARIDELSALLPPSDSRVKENPLAHISALLPSPFKKANNKSSSTNPLVSVIMGSDSDLKVMNAAAEILKKFEIPYELTIVSAHRTPDRMVEFAKSAPSRGVRCIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSSLDGVDSLHSIVQMPRGIPVATVAINGGLNAGLLAVRVISAGMPRLLNSLDEYKRGLEEEVYAKIDKIEDVAWENYKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA42</accession>
    <name>I4YA42_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_46991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959096.1">
        <property type="nucleotide sequence ID" value="XM_006959034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA42"/>
    <dbReference type="FunCoup" id="I4YA42">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA42"/>
    <dbReference type="GeneID" id="18472406"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46991"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA42"/>
    <dbReference type="OMA" id="LEMEHYA"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="639"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="899"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="946" mass="105284" checksum="6BD153AC3A043FF4" modified="2012-09-05" version="1">MMSFLNNANKNENVRLNIKTVFLSSNYSLSDQDKKDVVGKFYKLNNRYRLNDKRVKVLLLEPFNRGVIDENTNVINLVSDDSDEEEDNSDDDIDIDISQEFIQKSILGSPSLKSISVDLHPEIATSALSTHSLQIRTSDLTHLQLFNGDWVIAHLSHSPHSPRLIQVFLSEQYLPKSTTLISSQLFFNLNNGRNTSDAKITLNSLSSSPIIPIASSATIARISSPITIDKTYQERFHKALQDYFNYSARLYRRGDVFSVDIPVESVDKPRFEQDEQQNLQNHPLLRSKRTAKVWFKVTQLSVTATQKSPIGNGDLGAWILPGDTGMLTLGVQQSYVPRDINQLSSKAFKTMRELFESALKSHDMGLDVQLTLMTIGQRGSSKSKTIESTAHALGLHYLKVNCYDVADDNESQVEGSLQARFEKGAGCTPIVLHFEDVDALFSKNEERKGSRVATVFKECLKYLKEMSNKTGLPAIVTASTTDSDILPSAFSGCFKHEIRFEAPDRADREAYLEHLLTDMQVASDVSTKELAEHTASLFPADIDNVVSRAHINALKRALDMSRDYVLEDILSAGITISSRDVEDALKKSRANHSTNIGAPSIPNVKWDDIGGLKDVKADILDTVQLPLERPELFAGGLKKRSGVLLFGPPGTGKTLLAKAVATECSLNFFSVKGPELLNMYIGESEANVRRIFQKARDARPCVIFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSAGNSDVFVIGATNRPDLLDSALLRPGRFDRMIYLDVPSSHSSQAAILEALTRKFKLEPGLDLLNDVAAHLPLNLTGADLYALCSDAMLKSMTRKVMSIERKITSINELDDKEFIKQYGSQLRRPLIPQYYLEFMASSDEIDVVVSKDDFDEAMNDLSPSVSQAEMEHYRQAQRKFTNVSESKESKESEIQKELKKDKGKGKGKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA46</accession>
    <name>I4YA46_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959100.1">
        <property type="nucleotide sequence ID" value="XM_006959038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA46"/>
    <dbReference type="GeneID" id="18471612"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33048"/>
    <dbReference type="eggNOG" id="ENOG502TM0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_6_2_1"/>
    <dbReference type="InParanoid" id="I4YA46"/>
    <dbReference type="OMA" id="HYLTIHA"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="16162" checksum="2FEB5C323F8C41CB" modified="2012-09-05" version="1">MTIVIKSEFGDKNELYEVCKNIRIEVFTKEQGFEDELDENEPTAEHIVIFVENKPAGTIRLVEKSGKGKLTRLAVLKEYRNLKLGGHLIKALIDKAKERGYKEILCHSQIPVVGLYQKYGFEVFGDEFDEDGAPHLPLVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA74</accession>
    <name>I4YA74_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959127.1">
        <property type="nucleotide sequence ID" value="XM_006959065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA74"/>
    <dbReference type="FunCoup" id="I4YA74">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA74"/>
    <dbReference type="GeneID" id="18474136"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60744"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="InParanoid" id="I4YA74"/>
    <dbReference type="OMA" id="WTYFTST"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="294" mass="33669" checksum="E3F781F2117CDE44" modified="2012-09-05" version="1">MSTNLSLYDVLADGCHKYIPKEYHLPSYLMKWTPGVTPLSTTPEVGYAIVAYLAIIFGGREIMRGRPAFKLKIPFQIHNTILYVGSALLLALMAEEVVPMIYKHGFYYSICNTSAWTRRLEFYYIVNYYFKYIELIDTVFLVLKKKPLAFLHVFHHAATAALCYTQLEGETAVSWVVISLNLAVHVLMYYYYYATAGGKKIWWKKYLTTMQITQFIIDIFIVYFATYQHYGYRWGWPHVGDCTGSRFAAFCGCGLLTSYLFLFIAFYIKTYKTGKGATVQKAVTEAGTAGVKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC6</accession>
    <name>I4YAC6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958916.1">
        <property type="nucleotide sequence ID" value="XM_006958854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC6"/>
    <dbReference type="FunCoup" id="I4YAC6">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAC6"/>
    <dbReference type="GeneID" id="18475573"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69366"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_1_1"/>
    <dbReference type="InParanoid" id="I4YAC6"/>
    <dbReference type="OMA" id="ANTIAWM"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="323" mass="35670" checksum="03CA30F0507FDC31" modified="2012-09-05" version="1">MLISQNLRNHTNSTARRFTRQFTFHVGCSWASKPRLDSEEDFKKKSAYSDKHEVAQWRTKMLGDRYNLIGDAGEDFWFIEPLKNDSGIALGVADGVGGWFSAKVDPSKFSQTLMWAASKKAGNLIASEAQPKDLIEAGHQGVLKMEEVKAGSSTACIVTLDAKTGLLKGANLGDSTFILIRDNEVVESTKQQTHFFNCPYQLAKLRKGIDKNHITDYANSADLFETTLQEGDCIVLFTDGLGDNVFTNEIVQLKQAVEGHIPDGTITEKSQALADTLVSYARICMDDEFKVSPIELSARQEKIKGFMGGKVDDVTVITAFVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAH2</accession>
    <name>I4YAH2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958957.1">
        <property type="nucleotide sequence ID" value="XM_006958895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAH2"/>
    <dbReference type="GeneID" id="18472957"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57814"/>
    <dbReference type="HOGENOM" id="CLU_567663_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAH2"/>
    <dbReference type="OMA" id="CEMVFLY"/>
    <dbReference type="OrthoDB" id="10593178at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="481" mass="55208" checksum="E5B7B1B787A90E5C" modified="2012-09-05" version="1">MLLPPDVNDRMQDNAETWLNKITQVVKKLGIRYVEPASLDTTIMQIDMDCLKFTKPTKEEEIQETSSSLHPRESGQPLGPTSEHANVQSSIREPDRTPLRESPPQPLAENSRKRKASKDPDEPQKRLIRRAGGKRAQRVDLDDDIVDVSVEPSKPSTTMQDQPQAEPSEPPQQPVAATPMRRRTGNRRSRSINIDESDDERPPVQETIPEVIREIPDTVSQQSPEVSPPQQRSTLRRRANTRKMQTINIDDSDEEPFPAPQPTQAQPVSSEKPGSSAMKPEQSQAVKRTPEPVEKRRTARERVEEQMQAKLEPGRDFLAEHIDKRKKTLLDERQKNMAVQEMRKAEQEALLSAQKEASKQPEKTRSRPIKRSLRDDFDDDIPNTNNGTSRPLNDCLIPMKLIPLHRRDRPAIGEESGTKNAPNFKKFKRKIDHRYQPRVEVGLRDRHTQIRPRPRKESKMTIEMSSDEDELFGDEYLDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ1</accession>
    <name>I4YAJ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_8144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958900.1">
        <property type="nucleotide sequence ID" value="XM_006958838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ1"/>
    <dbReference type="STRING" id="671144.I4YAJ1"/>
    <dbReference type="GeneID" id="18475835"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_8144"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2009513_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAJ1"/>
    <dbReference type="OMA" id="TINQWIK"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="124" mass="14514" checksum="990D3FA2A67BA8F4" modified="2012-09-05" version="1" fragment="single">DIKKSYHKLALQHHPDKDPSADASERFQKVSFAYAVLSDEGKRSKYDKTGRTSDLGIEINEDFTWDDYFNEQFERVTWEALAEDRKRYQGSEDELNDLKRAYEECDGDLDQIFSQIPHSSILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAL6</accession>
    <name>I4YAL6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_39192</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958994.1">
        <property type="nucleotide sequence ID" value="XM_006958932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAL6"/>
    <dbReference type="FunCoup" id="I4YAL6">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAL6"/>
    <dbReference type="GeneID" id="18472103"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39192"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_2_1"/>
    <dbReference type="InParanoid" id="I4YAL6"/>
    <dbReference type="OMA" id="FAQYVHT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
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    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <dbReference type="PROSITE" id="PS51195">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <begin position="341"/>
            <end position="369"/>
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    </feature>
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            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
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            <begin position="561"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="757"/>
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        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="200"/>
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        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="969" mass="107802" checksum="F7C2FC9CFEDF679E" modified="2012-09-05" version="1">MPARTSSPESSKRYHRDREDEVDYHRSGRERDRRERERERDRDRDRRNRDRYRRRSRSPPARNDRNDRNERDQKPTEKPAESTPQKEKTEDRKKRMEAFLAARKAAKAKESPAPSQSQSPATPAAPSNNQSAQQKPISLGLKAFSNRNITTKAATMDYDEESNSLAMHTLPPVQSSIPTNSIGGDIESTEDQGDKMAVDEPSEQPQEEEEEEEDPLDAFMSGVKEEVTRVNESDKKRMGTKPNTVTAARLDDDDDDEEEEQKEEDVSKMSAEDILALAASRVKRKEVAVTDHSKVDYEPFRKSFYNPPSEIQNLSEEDAENQRLLLDGIKIRGIDCPKPVTKWSLLGLPSSCLEVIKYLQYDQPSSIQAQALPAIMSGRDVIGVAKTGSGKTIAFLLPLFRHIKDQRPLENLEGPIGVIMTPTRELAVQIHRECKPFLKALGLRAIAAYGGSPISEQIAEMKKGAEIVVCTPGRMIDLLAANSGRVTNLRRTTYLVLDEADRMFDMGFEPQVMKIINNVRPDRQTVLFSATFPKQMESLARKILQKPLEITVGGRSVVAPEIDQQVEVREESSKFNRLLEILGQTYNEDDEARTLIFVDRQEAADNLLFNLRIKGYVAMSLHGGKDQVDRDQAITDFKNGVIPIVIATSVAARGLDVKLLKLVLNYDAPNHLEDYVHRAGRTGRAGNKGTCITFITPEQDKYSVDIEKALTASGASVPSELKAMSEAFLQKVKEGKATVAGSGFGGKGLDRFEKERQDLEKAQRSAYGEDEEVKKDGAASAATNEKVSKETEDMFGEIKIQKGPAPADYKPLNLGASTDSSDIKPENATSAVAKAAAVAAKLSMQRGAAVSATLGGPIKNKDPDATDYHAIIPINDYHQRARWKITNKETIVYLNETTGCSITNKGIYYEPGKEPSLADQPKLHLLVESNEIERVEKAVRSIKFILIEATQAALEFDAKNQTTGRYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAW6</accession>
    <name>I4YAW6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958786.1">
        <property type="nucleotide sequence ID" value="XM_006958724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAW6"/>
    <dbReference type="STRING" id="671144.I4YAW6"/>
    <dbReference type="GeneID" id="18472945"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57713"/>
    <dbReference type="eggNOG" id="ENOG502S27K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421490_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAW6"/>
    <dbReference type="OMA" id="QPHINSG"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="548" mass="59306" checksum="55BC2544DEC18706" modified="2012-09-05" version="1">MSPPRPPPKAAVEPGTEIGTLVVVVDRARNLVDKQRIGKQSPYVTLRIPSSPVPTKRTQTINRGGQAPEWDAELRFPIMSELEDTLGVKSNNGKSMTVVCWADDSREPTKVGEAFVDLTRSLTKGEDDLWVPLTLDSKDGGKYRGEVRLELTFFSNASPPPKKYPTKPPVQTVATPTKPPQKRHPRMSAPGPGAGAKLAHPASLRPAHPPQSLRGRQSLSNMSLYRPDYMDGGVERIPGNDIRVPGNEIRIPSPLPSPQPQHMAYQPPVSPGPGVAGIDAGMGNAMGRQPSPNPYMMQQQAAYQEDPVVYQEQPQQPVYQVSPGHSPIPQVTPVPPPRTSPIPPVAQVQVGQPVGNSPPVYNAYTPQQVSQPPGQSPVYAQFGGMQGPQMPIAQTAAVPTPPHNGWTQWQNPADVQYGQQGPPQYGQTPPQGQQFGQTPQFAQTPLGFAQPPPPAQAPQPTQSRPLPNAPVIQSPFPTYPPPPPTMAYPMHPQSTAQQPMPPQQPMPSQQPPHMYPNYPPPPISSIYNGFGSPPAPPIQTHPNQHIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAX7</accession>
    <name>I4YAX7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_46527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958796.1">
        <property type="nucleotide sequence ID" value="XM_006958734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAX7"/>
    <dbReference type="FunCoup" id="I4YAX7">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAX7"/>
    <dbReference type="GeneID" id="18472387"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46527"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="I4YAX7"/>
    <dbReference type="OMA" id="GEKTGFW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF22">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="60"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="236" mass="25324" checksum="7E5FE3C637AA6052" modified="2012-09-05" version="1">MSSSTTLPKVLIVLTSADKTVDGHPTGFFISEIAHPFSKIATHVDVTFASPKGHSVVDPASVEMFKEDIESMSFLKDRADKYQKNVPLSEINPREYDAVFVPGGHGPSVDLITDNTFARVLSGVYQAGKPVAAICHAAGTLGSVVDRNGNSIYNGRTATAFSNLEEEQVGKVQSVKELPEDHIKRHGGSYVKAAEPWGERVVVDKNSDGILITGQNPASGHKLGEELLKAIRETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY9</accession>
    <name>I4YAY9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_54721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958806.1">
        <property type="nucleotide sequence ID" value="XM_006958744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY9"/>
    <dbReference type="FunCoup" id="I4YAY9">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAY9"/>
    <dbReference type="GeneID" id="18472688"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54721"/>
    <dbReference type="eggNOG" id="KOG3257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAY9"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="15793" checksum="67E67A4E94B72B48" modified="2012-09-05" version="1">MSKGAQTVATTLRCLIPAQKAAPTPPVGPLLGARGVKSMDFCKEFNAKTGHLIAGVPTPTQITINPDRTFSFTIRSPPTTHLLKKVAGDIEKGTGQPGHETIATISVKHIYEVARIKSMDKDLEAKGLENVARSVISTAKNMGIEVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB61</accession>
    <name>I4YB61_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958875.1">
        <property type="nucleotide sequence ID" value="XM_006958813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB61"/>
    <dbReference type="FunCoup" id="I4YB61">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB61"/>
    <dbReference type="GeneID" id="18471583"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32905"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB61"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="22854" checksum="CE339FB8F4D8772F" modified="2012-09-05" version="1">MTDKIDDTELETSTTPGYNPGEKKTVDEYAKLDQHDESLNKWKASLGITGDASAPADKPKVEFLTLSLEAPTLNNPIKFNLSDFIPNQSAESKQHLKSNPVNIKENSDYNVKLDFKVNYDVISGLKYVQVVKRSGITVDKLQEMIGSYGPKAEVYEKRFPTEESPSGMLARSGQYQVRSRITDDDGNLYLDFEWSFKITKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB92</accession>
    <name>I4YB92_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">WALSEDRAFT_60491</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958590.1">
        <property type="nucleotide sequence ID" value="XM_006958528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB92"/>
    <dbReference type="FunCoup" id="I4YB92">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB92"/>
    <dbReference type="GeneID" id="18473981"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60491"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="InParanoid" id="I4YB92"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="270"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EIM21234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="613" mass="69479" checksum="2CF1E2AE9F046E7E" modified="2012-09-05" version="1">MFLNKFYQPIQLNQQNNLINPFWQEQLVRAEAIRSSSSPHHRARAAALAQRGQQSSAIAILDPSRRMSTPKQNSASLNQVSPTTPNAHPSASNVPSNSSDKLSSNSSWMALDLGGMQLKSLSPSLFTYQFITNLFINHNNLTFIPPEIYKLNQLVLLDLSGNNLSSLPAELGLLSRLRELLLFDNNLVSIPSELGTLYQLEFLGIDGNPLAESFRQLIQKEGTPALIAYLRDSCPVSTGPPEREWLAMETDLPSPKEDDPPPETFSLLCYNILCDKYATSQMYGYTPSWALNWDYRKEILLQEIMGFSADIVCLQEVDIEQYEDFFLNQLSQHDYRGVYSQKSRAKTMSENEKKRVDGCATFFKASKYQLIESEVIEFSQVALQRSDFAKTEDMFNRVLTKDNIANVALLENIESGTRLIVANVHIHWNPEFRDVKLVQVAILMDEIEKISKRFSTLPPKLNVQSGKKGPVYTDMSKIPLIVCGDFNSVPNSGVYEFLGKGYVDRNHEDFMEHQYGAFTTEGMRHKFALKSSYANIGELPMTNYIPGFEEVIDYVWYTQNTLSVIGLLGEVDQSYLNKIVGFPNVHFPSDHLSLFTEFRLRPPSHITDVSRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS4</accession>
    <name>I4YBS4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_46040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958447.1">
        <property type="nucleotide sequence ID" value="XM_006958385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS4"/>
    <dbReference type="FunCoup" id="I4YBS4">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBS4"/>
    <dbReference type="GeneID" id="18472377"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46040"/>
    <dbReference type="eggNOG" id="KOG2629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045718_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBS4"/>
    <dbReference type="OMA" id="YNQWQPP"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="252" mass="27837" checksum="498ADF0191B6BC18" modified="2012-09-05" version="1">MSDKIQSAIDFLNDSNTQSTSLESRLQFLQSKGLTEAEINTALASANNNRRNIYLAQQPGYQLERDWRDYFIMAVVSGGLVYGIGTLARRYLWPHLQPPTSTQYESDLEALNSKFDQAESTINELRTDTAAIKDSLVGQQEKVNETVVEIERAIESIKSNEKRSRTEIDGVVREIADIKAQIPKLVESQQQSQSNTLSDLQSELKSLKSLISSRQNTGATSPSSSIQIGKPQIPAWQLATANGATSPSTNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC06</accession>
    <name>I4YC06_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958527.1">
        <property type="nucleotide sequence ID" value="XM_006958465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC06"/>
    <dbReference type="GeneID" id="18475519"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69061"/>
    <dbReference type="eggNOG" id="ENOG502S71Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138679_2_0_1"/>
    <dbReference type="InParanoid" id="I4YC06"/>
    <dbReference type="OMA" id="RPWWKIF"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="102" mass="11841" checksum="06A1478FE181DB54" modified="2012-09-05" version="1">MASQKSKLLWIAKEWPFTKLRPKLQFKNLVQNIHDKSHEHEQIAGKSVLALEALLNNKHYNKYPLSAKMLKPASAPNHYDKVLDAVDGKPIHKSFLQRFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC14</accession>
    <name>I4YC14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho termination factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958535.1">
        <property type="nucleotide sequence ID" value="XM_006958473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC14"/>
    <dbReference type="GeneID" id="18473966"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60469"/>
    <dbReference type="eggNOG" id="ENOG502S8AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829501_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC14"/>
    <dbReference type="OMA" id="VRLACVW"/>
    <dbReference type="OrthoDB" id="5569309at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34545" checksum="DE8747F3C57212E7" modified="2012-09-05" version="1">MPSTLVLTDIKQKRKAELVEFAQKLGVETEQLNRIDLIDNIKKHMQKNEDKLKDDAEYAQYFGDRKKSRKSVAVNDEVEDDGESLDSSATGRATTPAIQQFREKSVDVIHTSPKRVADFIEDGAANAVHEIESEANQLVEKLSQNAIKLRNCTKDTVNKMQNWLSDSQHLLLVGLLIEFLVVLYSITPIRIHRIDIPEQVQKYTTDSINLKLPYAKSLLSPPFVNPLKKYFIYSLIVPFIPSVFINFDKRGFSPLTFTLVRLSLIVIFNSQSSIESYFPLKIELALVSLLASFSLVELLSKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC44</accession>
    <name>I4YC44_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_64484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958559.1">
        <property type="nucleotide sequence ID" value="XM_006958497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC44"/>
    <dbReference type="FunCoup" id="I4YC44">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC44"/>
    <dbReference type="GeneID" id="18474931"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64484"/>
    <dbReference type="eggNOG" id="KOG2387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="InParanoid" id="I4YC44"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="315"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="617" mass="68395" checksum="7823C61D7F6FD354" modified="2012-09-05" version="1">MKYILVTGGVISGIGKGVIASSTGLLLKTMGYKVTAIKIDPYMNLDAGTMAPTEHGEVYVLNDGGEADLDLGNYERYLDVTLGRDNNLTTGKIYSHVIEKERKGDYLGKTVQVVPHITGAIQDWIERVAHTPSDETGEVADVCIVELGGTVGDIESAPFIEAMRQFQFRVGHENFALTHVSLVPVISGEQKTKPTQATVRELRGLGLLPDLVACRCEQELQAETINKISMFCHVSAEQAIGVHNVSSLYHIPLLLEEQGLGKYLDKRLGLSEIKKSQAMINRGLDIHKKWGNLTVGYERLFESVEIVLVGKYTALQDSYMSVIKALEHASLRCGRKIHIKWVESGHLEPETETKDPTKYHEAWHTLCRSNGILVPGGFGSRGTEGMILAAKWAREKKVPFLGICLGFQVAAIEFARHVLNWSDANSSELDPNTKHDVVVFMPEISKTHLGGTMRLGLRPTVFEEGSENWSIARKLYGGSKNIWERHRHRYEINPKLVDSLESTDQVKFVGKDESGERMQVMEMRDHPYFIGMQAHPEFCTRPLNPSPPFVGLVAAASGQLDAHLDLQKDYKPPHPTTEMVLGEKVGKNNVIKSAINDAEFNTPTQSPKVNTKDLPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC55</accession>
    <name>I4YC55_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958569.1">
        <property type="nucleotide sequence ID" value="XM_006958507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC55"/>
    <dbReference type="STRING" id="671144.I4YC55"/>
    <dbReference type="GeneID" id="18473978"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60486"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="InParanoid" id="I4YC55"/>
    <dbReference type="OMA" id="QHALKFY"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="230" mass="25005" checksum="97315F938FC628CB" modified="2012-09-05" version="1">MAQNGLDEGAAGHLTVRDSLDGSTFWVNPFGVPFDTMTVTDLLRIDHTGAIIEGGRSDQMFYNEAAYVIHAAVHSARPDANAVCHSHSPYSKAFCAFSKPLSMVSQDACLFYNDHAVYETFGGVVLKGEESKAIVRALGQNKALLMANHGVLTVGTTIESATFWFYSMEKQCQVQLLVDAASKGNASPKIISQEAAQFTFDQTGNESVGWLDGNTLFRSTEVRCKGEHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCB0</accession>
    <name>I4YCB0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_32515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958297.1">
        <property type="nucleotide sequence ID" value="XM_006958235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCB0"/>
    <dbReference type="FunCoup" id="I4YCB0">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCB0"/>
    <dbReference type="GeneID" id="18471503"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32515"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="InParanoid" id="I4YCB0"/>
    <dbReference type="OMA" id="VWAVKPQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="319" mass="33511" checksum="5FF5C6D9A9CDFFED" modified="2012-09-05" version="1">MGYRLCVLGCGTMGVAVLSGVIEGLNTRKSVGMINFDNDNASGTSTPVDLSSSQAILEAKEGSLPSKFICTVNRSESAKSLRKTFDALGDVGKEVNILQGKGVNIQAVRDSDVVLLCAKPQMAHSILSEPGMQEALSNKLLISILAGVTISQISSWVPESTKVVRAMPNTPCKIREGMTVVSALPSEWTFEKDLILAIFRSIGRCRFLEEKHFDACTALCGSGPAFAVTVLEAMADGGVMMGLPRAEAVELAAQSMQGIARMVLETGVHPAALKDSVTTPGGCTIAGLLALEDGKVRSTMARTIQVATTHAAGLGQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCF3</accession>
    <name>I4YCF3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958339.1">
        <property type="nucleotide sequence ID" value="XM_006958277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCF3"/>
    <dbReference type="GeneID" id="18471515"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32548"/>
    <dbReference type="HOGENOM" id="CLU_1556477_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCF3"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19236" checksum="2027C288141E5C61" modified="2012-09-05" version="1">MHFKVILDGRLEEACSTLILSPSLYVDWDEITRLDNAHKLGSRTPVLLQGNTNVELPEVALDSDDNRTIVQFHTNHQLIEVPVHGRYPLVKKEPTSYLETGVVESTLISSYHSCDTIQSDSQYTNTVYLPTGSSDHEQIVGRVNVTITLLAFAFIIGSVIKQFSRGLHVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN7</accession>
    <name>I4YCN7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958040.1">
        <property type="nucleotide sequence ID" value="XM_006957978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN7"/>
    <dbReference type="FunCoup" id="I4YCN7">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCN7"/>
    <dbReference type="GeneID" id="18471465"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32331"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCN7"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="359" mass="39030" checksum="00E3D4A36DD8D614" modified="2012-09-05" version="1">MSGALSVVPAGVLSGVEALKLFEHARENKYAIPAVNITSSSVANAVLEAARDIKSPIILQVSNGGGAFLAGKGLANDKQQASVAGSVALAHHVRSVAPLYGIPVILHSDHCAKKLLPWFDGMLDADEAYYKINGVPLYSSHMLDLSEETDEENISTCVKYFQRMAKMGQWLEMEIGITGGEEDGVNNESASAESLMTKPEQVYKVHKALSAISPSFSIAAAFGNVHGVYKPGNVKLTPTILGEHQKYAREQDNSKNEKPLFLVFHGGSGSSKEEITTAVKNGVVKMNVDTDVQWAYLSGHRDYILSKKDYLMTQVGNPEGADKPNKKVFDPRVWVREGEKAIVERVKESCRDLLSENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCR6</accession>
    <name>I4YCR6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_28472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958067.1">
        <property type="nucleotide sequence ID" value="XM_006958005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCR6"/>
    <dbReference type="GeneID" id="18471045"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28472"/>
    <dbReference type="HOGENOM" id="CLU_874941_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCR6"/>
    <dbReference type="OMA" id="DYLTIDM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="318" mass="35241" checksum="FA994DACBFB0F07E" modified="2012-09-05" version="1">MYRTVSTPSPPSSQILKGDSPSCYPYTYPQGTNSLKRNIRFSIPREYGLNNLGLAAGSHEIVNKQTPSPSSNSALPGLAESLDPHTQNHKGVLEPSPFTWKTESKGDNTSSSQSSPANNPFAAPLNPHISRTNNVKTRPSLISMKSNASDVPKDDKITYSKTKDKLWLSEDASTLEVWVTIMKFVNDEYTQTELLSRTSQELIEKLIECVKKYDDCSTLNLIEEFLTDFTTCSNSLRNLLTAKRYGLPILHGTSLVKIQPHMIPTLTVEQIELIGAEDMHVILNSSQCLNLLQLLVGNPYATKSLHLVNLSGNKETVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU3</accession>
    <name>I4YCU3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958091.1">
        <property type="nucleotide sequence ID" value="XM_006958029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU3"/>
    <dbReference type="GeneID" id="18474892"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64016"/>
    <dbReference type="HOGENOM" id="CLU_1327305_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCU3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="207" mass="23147" checksum="ACC0A2F6D465B81A" modified="2012-09-05" version="1">MKSAAKNADSSNELTPTEEIPGYTSNDSGFASDEEYSEYGTTPDHDGRKEVSSLKAHDITPWWHSQQSTMSGASTTPEEYNNYGITPESISPPTSRHVRFNSRIHLYRPHTASSAASSISGSLRSTSSVVSPYNANRRHSLMPIMQIKQARINERSRLMGADNSKNDDDIDVLYGKFPKRLLNWEYIRSIICGNCCDSLNYNDEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCW9</accession>
    <name>I4YCW9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Delta-12 fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958115.1">
        <property type="nucleotide sequence ID" value="XM_006958053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCW9"/>
    <dbReference type="STRING" id="671144.I4YCW9"/>
    <dbReference type="GeneID" id="18474898"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64045"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCW9"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="201"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="416" mass="47256" checksum="F491924A3CFE0B2E" modified="2012-09-05" version="1">MVEKFAVPEISIKDLLNAIPADCFKRSSFKSSLYVVQDVILSYLLIKGSFYIPVLSQTDNHYLSLAISSSLWALFWFAQGLVWTGIWVIAHECGHQAYSTSKTVNNTVGFVLHSFLLVPYHSWRISHGKHHAATGHMSRDQVFVPKTRSQRKGPKIDYEDADEKVLAGVDVPEHEQLKVSELLEDAPLATFVNVLLQQLLGWPMYLIRNASGQRHYPRGTNHFNPSAIIFDARHFGQIVLSDLGVGLMLGALYYWGKQRGFAEVVNYYVIPYLWVNNWLVCITFLQHTDPSLPHYREGMWNFQRGALCTIDRTFMGPIGKHILHGICETHVAHHISSKIPHYNAWKATDALKAYLGPHYHYCGDNVIVSLFKNYRNCVFVEDKGDIVFYKDARGRASRVADTKPNQGFSDSGIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD38</accession>
    <name>I4YD38_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958181.1">
        <property type="nucleotide sequence ID" value="XM_006958119.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="I4YD38">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD38"/>
    <dbReference type="GeneID" id="18471487"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32430"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002664_0_2_1"/>
    <dbReference type="InParanoid" id="I4YD38"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="794"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117384" checksum="DEAEEC06EE208BC2" modified="2012-09-05" version="1">MTTTTSQIQSVHQPHHQQHQQPQTTQQRSTSKARMLGDYVLGKTLGAGSMGKVKIGVHVTTGEKVAIKIIPRYTSTNALNAIPPHQPKPTQSFIKKAHNKDISKEVRTIREASICLLLFHPFICGMREMSVYSQHYYMLHEFVNGGQMLDYIIAHGRLKERSARSFARQIASALAYCHANSIVHRDLKIENILISKTGNIKIIDFGLSNLWSPHSNLNTFCGSLYFAAPELLNARAYSGPEVDVWSFGIVLYVLVAGKVPFDDQSMPALHAKIKRGHVDYPAWLSTECKSLLSRMLVTNPLLRASLSEVSSHPWMVKGHSGPPQTHLTKREPLRPDMTFDTDVIKGMKGFEFGNSHDIERKLRDLLNSPAYRNALAEWDRKNLNVYHRSEPDLNSSNSGHFDLSAQVQHTPHHHRRFSQQFSSKVQSDVDKELPPSLSASQALSSQHDANNQRSSRLSKRFSGLDFYKRKITGSSIANAFTSINDQPQINERDQKFEPTKISLDPTQGFHPLISIYYLVSEKIQRDKAFGPGLFASSQMSLATMANQPSQPVSNLDQNLYAQYERSRAPPPVQPIPLPQPENEYPGVRRSTSNGSMMQQPVSRQRVNSSRSRPLTMADFNQNGSATVQMSRTQSQRRPELNSQTVVRSPSSPAMNSRQRSRANPLDVGTVTPIQPPPAMRDNKDYPLPPPQASAHKRSHSLSQKPEMSPPSPTTAAANPMTTINEPESATQSKGLAKRFNSILHRQTTLNEGSDNNNPRQRVNSTNSYKATNRLSMLSKGSHPTKAQAHNDAVNKLEGNNSPSNHRRAHTVVEKKREPKVDINHDRNYSTGEPKTVHTVGRYSGVGPWVQASKKSTDDKNSTSSRDSPVQEISQNLNEEFDPVEEPKAVWGKGLFSVATTSTKSSNTLRSEIGSTLSKLGVSYRLTRSGFECLHQPSISVGGVGSKRLEGSGDYTVKDMKSDSSEHMKFGKYVKKKSSKLSFNSSKKASNHDNLVLDEGGANSGNPNASSSKVRFEINIVRVPLLLGINGIQFRRITGNSWSYKAVAQRVLGELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD48</accession>
    <name>I4YD48_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958191.1">
        <property type="nucleotide sequence ID" value="XM_006958129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD48"/>
    <dbReference type="FunCoup" id="I4YD48">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD48"/>
    <dbReference type="GeneID" id="18471489"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32437"/>
    <dbReference type="eggNOG" id="KOG3504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
    <dbReference type="InParanoid" id="I4YD48"/>
    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="64" mass="7275" checksum="56FDEEFAB38912A2" modified="2012-09-05" version="1">MAKSKNHTNHNQSAKAHRNLKFSQRARYPSKKGVDPKFLRNQRYATQGNIKKALAIRKGAVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD71</accession>
    <name>I4YD71_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958208.1">
        <property type="nucleotide sequence ID" value="XM_006958146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD71"/>
    <dbReference type="FunCoup" id="I4YD71">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD71"/>
    <dbReference type="GeneID" id="18471492"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32451"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="InParanoid" id="I4YD71"/>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27935" checksum="7B3536B82E8FE623" modified="2012-09-05" version="1">MSTPLPGSSDVIIKEGPFVYLSDWDGTITTQDSNDYLIDNFGMGKENREKLNEDILSHKLNFRDAFYEMLRSVSKAKSFYECMEILKRDIVLDPGFSDFYFWAKMNNIPVIIVSSGMAPFIRSVLSKLIGEEEAKNIDIISNDVKFNDPEGKDWEIVYRHPESGFGHDKSKAILPYRDLPQPPTLFFSGDGVSDMSAAKHADHLYVRKEKDLEKYCVAQNIPYTPFDTFTNIKNYVIDAINKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDA8</accession>
    <name>I4YDA8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_28227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957762.1">
        <property type="nucleotide sequence ID" value="XM_006957700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDA8"/>
    <dbReference type="GeneID" id="18471030"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28227"/>
    <dbReference type="eggNOG" id="KOG4379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021382_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDA8"/>
    <dbReference type="OMA" id="DPEESTW"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="441" mass="49085" checksum="82B68CFBA21C5D12" modified="2012-09-05" version="1">MSETKWAFSDGSGRLFINDDVKELTNDGTLLPFYIHKYIQSLNTIVISTSLVGETTKFDLIAINLDRAAESLNHGIMWRLRSDDFPSLVEYVANEWCLASSSAFTKVDNDGGDLIAEEEPAQSVTTEKSKPTQNQCTWSQDQDAVSIIVHLTEIGNKESYAPIIKTKEIKIPSLSNDTLPLYDEIDIDSSNWTLNRQLSQLEIDLGKKNQTARWISLFDEHFKPPFEITDERLSEQHLQSALSSLEKYTEEGDGTQSPKIRPGGLSDDIPSLAKGEMDDNVDSDVGRLFTLTKFSNVDELQHFTCQRLLSTPLPSYPKQDSTFIISDETTLTGALFDTKSVKNLDSFAALPFVIASKRDLKFTHHLSNELVIVFEGGNHKGAGNAFIYFQTESDQSDTAPQSVFQFCGYEKGSLLGVAYFKSQGILVGLCENSLVVISDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB1</accession>
    <name>I4YDB1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_51002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957765.1">
        <property type="nucleotide sequence ID" value="XM_006957703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB1"/>
    <dbReference type="FunCoup" id="I4YDB1">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDB1"/>
    <dbReference type="GeneID" id="18472541"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51002"/>
    <dbReference type="eggNOG" id="KOG3109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDB1"/>
    <dbReference type="OMA" id="YPHHVNL"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="27809" checksum="ACC0E14F3485208C" modified="2012-09-05" version="1">MKSVIWFDIDNCLYGRSARINEMMSEKIANYFLKLGLSEEEADKLHREYYIRYGLAIRGLVENHKVDPLDYDYHCDASLPLEEVLKPDLNLRKLLQDINRDEYRVWALTNAYKTHAYRVLNLLGLEDQFENVIYCDYTRHNFPCKPEKEFYVEAMEKVGLLDQPERNYFIDDSSANVKTAKEMGWNAVYYLEYNQQSIEGQDDETKRRFLHHDLQPVVGDLQELRQVWKEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDF4</accession>
    <name>I4YDF4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957805.1">
        <property type="nucleotide sequence ID" value="XM_006957743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDF4"/>
    <dbReference type="STRING" id="671144.I4YDF4"/>
    <dbReference type="GeneID" id="18473755"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60123"/>
    <dbReference type="eggNOG" id="KOG2098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018702_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDF4"/>
    <dbReference type="OMA" id="LGPDQIY"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="415" mass="47944" checksum="268A9AA6B1697C2C" modified="2012-09-05" version="1">MESAIMNILDNTSGYNINQLLRRLIFNYPDLGLTFNDLDKVSSKLIELGIDLPTTSYINNKDTLYDSYTRSVVPEDDYVKICSNTTRTECTEDCQKVHFQPIIRPYSDHALGHCSYLNTCYPFYNNAPPTLSNAFQPAKLNSPRLDRTCKYLHFQLESPSESAIEQADYQTKRRKKCRGDGLRQELDTILGSKRYPAQYINCDLRSFDYNTLGKFQIIVADPPWDIHMSLPYGTLTDDEMRKMPMSTLSEEGTLIFLWVTGRAMDLGRECLSIWGFKRVEEIAWVKINQLQRLIRTGRTGHWLNHTKEHCLVGMKVSDPDASDIQWPEWLNRGLDTDVIVSEVRETSRKPDELYGMIERCCPVGRKVELFGRRHNGRDGWLTLGNQIGEDEVYDPELSQRLNERYPEKGKLVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDS5</accession>
    <name>I4YDS5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957919.1">
        <property type="nucleotide sequence ID" value="XM_006957857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDS5"/>
    <dbReference type="GeneID" id="18473791"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60174"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDS5"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="381" mass="41769" checksum="90C317803666F107" modified="2012-09-05" version="1">MEDRWIGLLLAISSSVAIGMSFIITKKGLQDSSNKAGDNYSASDKLLYLKNPIWWAGMATMVVGEVANFAAYTFAPPVLITPLGALSVIFGAILASFLLHERLGPIGRVGCGLCVVGSLVIVIHAPEDKEVESVNDILNYAIQLPFIIYVAIVVIFSAVMIYKFVPKYGKKTPLVYISICSMVGSISVMSIKGFGVALKLTLAGNNQLTHASTYIFGIVVVVCIIIQMNYFNKALDTFSTNVVNPIYYVMFSTATIIASFILFQGFYETPTRDIVSVIAGFLTIFAGVYLLNKSRQIDEDALASKQAMRGTDPRHSISGRLSSAGAGGTMLDPPYERERDYEQFELPTHETQALNTLPERDESDDGMEDYTQKYDVEQGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDX0</accession>
    <name>I4YDX0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_68617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957961.1">
        <property type="nucleotide sequence ID" value="XM_006957899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDX0"/>
    <dbReference type="FunCoup" id="I4YDX0">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDX0"/>
    <dbReference type="GeneID" id="18475439"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68617"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="InParanoid" id="I4YDX0"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="142"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="344"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM22162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="435" mass="50287" checksum="B88DFCE0DBEFECA7" modified="2012-09-05" version="1">MMILRSQIARISKSSKLSVNLSLRYQSTLINGQSYSRDEFTNAPSSILALTERQLHQQPSHPIGILRSLIENSLNNYQHLTAPSPIVSTYKNFDELEFPEDHPGRSLSDSYYLNKTTMLRTHTSAHECDVFKKGTDKWILTADVYRRDEIDSSHYPVFHQMEGACVWDDTTKNVEKAIEEELHLLEKALAHTNVITEDVTVNNNPNNPYQLSQRPEVSGLIVKHLKMTLNLLVYNLFKHAQNVDAEPLKVRWIEAYFPWTGPSYELEVLWEGKWLELLGCGVMQQRTLERAGMGHKSGWAFGLGLERIAMVLFGIPDIRLFWSTDARFLSQFESGKISKFVPYSKYPPCIKDVSFWVNKPFHENDLYEIIRECSQDLVESVECIDNFVHPKSQRHSLCYRINYRSMDKNLTNEEANDLHASVIENIKKAFNIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE12</accession>
    <name>I4YE12_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957999.1">
        <property type="nucleotide sequence ID" value="XM_006957937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE12"/>
    <dbReference type="GeneID" id="18473812"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60205"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE12"/>
    <dbReference type="OMA" id="WMSIRQM"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF57">
        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="479" mass="53061" checksum="FF29DAEB40AAE4D0" modified="2012-09-05" version="1">MVAVAEKTKDISVKFYRSVLFNVIIDGLVSFLLPGLWYSLNYIGAAGLADPRQVNGANAVTFGIMIPGCTLAAVLANRTSLKWVLFAGAVLYTPYAAALYTLNRYNNIPFLYGGSVLCGLGASLFWCTESAIAIAYPLPHERGRMVSIWLGIRQFGMILGGAISLGYNIKGDSTGKISYSTYYAMIALMCLSGPAALLLSNPRKVRRSDGSHVKFAKNFNLKDEVIKIKNLATSRYLLALIPIFIFGQWGTVYQSNYLTTYFTVRTRALASLLAGIVSLISNLSVGWFLDQTRWNQRTRAAIVWIFLAVTISGAWIWNAILQARFSEDVNNGKTIALDWEGSTGRFNSAFAVYVLWKFLYESLETLLYWIMGCYNGGVNDITRTTGLIRSYQSIGSTFSYVVGAGLWPYFNQMILSLAFWFACLIPTCYAIYIVPKEEQVIDPVDELTSTDSDYEKGSPPETGNTTPIPPDGYNKETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE48</accession>
    <name>I4YE48_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957504.1">
        <property type="nucleotide sequence ID" value="XM_006957442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE48"/>
    <dbReference type="FunCoup" id="I4YE48">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE48"/>
    <dbReference type="GeneID" id="18473653"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59962"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002392_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE48"/>
    <dbReference type="OMA" id="STYITEW"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="818" mass="90222" checksum="0E9F4702F6310270" modified="2012-09-05" version="1">MAVGKSNGDIEIKHYVNTPVASHFSKKQPPGKGWVLVKTLPAHIPAGKIHSLHFTRRHSPPKKSGSYTDAITSLNPYTSDHLRLFSSSGTNTLIEWDLNTGKIANKLSSDGGAIWSVASSPSGKSLAIGCADGRIRLVNLSSNQFEIGRVLAHVPTRLLSVAWCRKTESNTDDEDYDEMKDGWLVAGCSDSSLRVYNLNDGRVSDRLSVDKAKNQHTLIWSVNVLEDNTIVSGDSLGSVIFWDRQSASQISAFKAHEADILTTCVSSDGETVFSGGIDQRVSQFTKISITADRLDTKFTQSGSKRIHTHDINAIAVWPPQGTTSEQALASQVPIVASGGIDPHLILTPGGKPTNRRTKQAQLDIAGYNPVSSSRSVHFSDAWHRRTPFVPLNGRNSVTVCRSRRWVVARRDSGISVWRVKSAEEETGDGGFEKILDTEFKFRTHLISHSVSPDGTVLAVSDAYETKLFAIAEDGPAIPKKVKLETPLPGANYIQFTPDSKRIILALSGATSVVVYELEEGKPKLLKEWSNKSTARSVRPMPNKSASMDVDGESEDETDDTKVEASIHTLACSKDGQWLALADYACRVQIFNLDSMQHHATLPSLSHLPSSIQFHPTQQSLMIIALPSGLLHFYDADKKSPPSWSKRINEATMPDHYLTTIDPVQGMIVNPDPSTLPPQFGAEIPGTLDPSRDNKIITYGASWMCVIRYNTTNKNTHGRSYSKKNNKRKLNKQERNKLAQDIALVREQMGEAANGVVFQEDELLRKSEESTFFKLTNRYQPIAMAEYIGPSELVVVERPQHDFIADLPPAFYKHKYGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE74</accession>
    <name>I4YE74_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 9">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_68261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957529.1">
        <property type="nucleotide sequence ID" value="XM_006957467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE74"/>
    <dbReference type="STRING" id="671144.I4YE74"/>
    <dbReference type="GeneID" id="18475368"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68261"/>
    <dbReference type="eggNOG" id="KOG0220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_7_3_1"/>
    <dbReference type="InParanoid" id="I4YE74"/>
    <dbReference type="OMA" id="KMTMLYK"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03243">
        <property type="entry name" value="ABC_MutS_homologs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="772"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="809" mass="89661" checksum="24D7747767BD7BEF" modified="2012-09-05" version="1">MSSDRFAILSTYAKKDTPSTILVCSTSVGKNQVEQSSKSLLVSRLLEYHKPANVKSIQRKHFNDIKGLDNIDNFILKDVTKDAKMMVLRSKYYAVAAASALFSYLDSVQTTVFAPNSLSISYQEHKGTMFIESQTAQDLELTTSAVGNAHGMSLLSLLDSCLSQMGRRLLRSSILQPLSDAKIIENRLDAIQELLLNADILNAIRSSFKSLKGIDLDKLLMAISKDENKSTAQDHEVEKRISQLLTIRSAIHAISNIYYALDGAKSSLLTTLRNDLHDDAFNCIISAIDENIEQDVTLGKSGSLAARNAKIYAIKSKQCELLDVAREAYRENLDDLFALSTKYTETYDLPITCTYINNAFHLTLKISDLGNSDLPKEFINVTKYGSKGKNKNNSENMAGRYRFTTIDLLKRNSRINDALAEVYLLSKQCVLDIRIVVIGCLSPIYRASDAIAMLDLIVSLTNAALIHDYIRPEFTDTLALKSARHPLLENLNSETIVSNDVFMSDFAHFQIIEGPNMSGKSSFLRMIALIVIMAGLGSYVPAEYASIKLMDGVLSRQTNNDVLEQNLSSFAHEMATVSLILTASTSNTLVILDEIGRGTTPSEGFGLAYAISEELIRRRPFVIFATHFRQLSTYLQFKPGVVTLHMSTTVGGSDEIYFQYKVAEGNSVEQHYGLQMAKSAGLPGEVLDEAHVIVRGLSSENEHGYDSVINQARKMAIRRQAVLSVTSKLRQICKNCTLNYQDLMIYLARLQSELVLSLEGTGMGDPEVASNVNEKFSMESNKRSSVSPTTSPMFISEDEAEQYQSDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEE7</accession>
    <name>I4YEE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957594.1">
        <property type="nucleotide sequence ID" value="XM_006957532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEE7"/>
    <dbReference type="GeneID" id="18473690"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60022"/>
    <dbReference type="eggNOG" id="ENOG502RZRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1901354_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEE7"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="134" mass="15144" checksum="EE841A5DF900AA13" modified="2012-09-05" version="1" fragment="single">MSTHNIPPSTLYWSPHSYPSSLVRLCMLEKIYESKDLKLIQVDLNMGDNFHPSFLSINPAGTVPLLLVPNAESIQPDRAPEFTRIADTKNICNFLATKRRSIPSLIPLPHLVKKSNEIIDYLHSGDLDTNFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP2</accession>
    <name>I4YEP2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_63629</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957677.1">
        <property type="nucleotide sequence ID" value="XM_006957615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP2"/>
    <dbReference type="FunCoup" id="I4YEP2">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEP2"/>
    <dbReference type="GeneID" id="18474856"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63629"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_4_0_1"/>
    <dbReference type="InParanoid" id="I4YEP2"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="325"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM22434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="861" mass="94726" checksum="CF833475B0B0BDA8" modified="2012-09-05" version="1">MIPRTKLGIRQTSAARRALYGASKRTFALSSRLCTPKPDLSHRDQLLHLLSNISSRQEIERYLRVFSSTTNKNFAVIKVGGAITTSPDLIHSLAVLHKLGLHPIVLHGAGPQLNQKLEDAGVIPDYIDGIRITDAKTLQVARETFLEENLRMCDELEKLGSRARPIPAGVFTASYLDKDKYGFVGKIDKVNKEPIEAAIKAGCLPILTSIAETPDGQLLNVNADVAAGELSKSLEPLKIVYLNEKGGLFHGVTNELIETINLDEEYSDLMKEEWVRYGTKLKLREIKDLLDHLPRSSSVAIISADQLQKELFTDSGAGTLIRRGYKLFKSSSIEEVGVDKLRKVLEEREPEIKSGLKTASEFFSDLKQHPYTIYGDEPLDVVAIVSHPEGETPVLRVFLPSTNGVLNNVVDNIWSQLRKNYRKLFWAARADDELRSWHFEKADGSFTRAGGSLFWYGAQSISEVEQTVKDYENRGRIERSFLPVGPPPAGRRTFMTSARPSVSKAVAMQIRARRGYATEAPKPKKVALIGARGYTGQNLVSLLNAHPHVELVAVSSRELAGKSLQGYDKANVQYEALGPQECAEMEKRADVDAFIMALPNGVCKPFVDAITSARDEKEGKGSVIVDLSADMRFESNWVYGLPELYGREEIKQSTRISNPGCYATNSQLLLAPLLPYLKQGSQPTVFGMSGYSGAGTKTGEKDANGIPVTLPKIDDVALGGACKPYALTDHIHEREAGFHLSRLGAGEINIAFTPVVGPWFQGIVSVASVPLERDMRASDVRKLYEDRYQNEKLVKFVNEVPTIPDISGRHGWIGGGIQVHSKGERVVVVGALDNLLKGAATQCMQNLNIALGLDEYASIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YER0</accession>
    <name>I4YER0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="13" type="ORF">WALSEDRAFT_44910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957693.1">
        <property type="nucleotide sequence ID" value="XM_006957631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YER0"/>
    <dbReference type="FunCoup" id="I4YER0">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YER0"/>
    <dbReference type="GeneID" id="18472347"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44910"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_0_1_1"/>
    <dbReference type="InParanoid" id="I4YER0"/>
    <dbReference type="OMA" id="DQFANLM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="146" mass="16607" checksum="D8C8CD5B931E8427" modified="2012-09-05" version="1">MEALVPFTTSGQLLNCVDKKMLVALRDGRKIIGVLRSFDQFANLVLNDAVERIHALNEYADIPRGIFLIRGENVVLMGEVDLDTEDTIQLKQAPIEQVLQKSLQLDEERAIKDSIRDEILKQRGFCTERVEGDVDVHRYGHSPYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX0</accession>
    <name>I4YEX0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_36484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957185.1">
        <property type="nucleotide sequence ID" value="XM_006957123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX0"/>
    <dbReference type="FunCoup" id="I4YEX0">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEX0"/>
    <dbReference type="GeneID" id="18471964"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36484"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010916_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEX0"/>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="428" mass="48409" checksum="3D97BD4B66BBCF5F" modified="2012-09-05" version="1">MATKEDIERKYDIRCDFISEGDSVLIRLPSLQEKVIKLSKNGTANFGKFGKVAFSELVGKPYGLSYEIIEKDGKSTLKRMSHKAVDDIEDFEATNQFIEDDTTAITLLGEAEIDALKKGGVEGRQIIEQQIAAHGQFDLKTAYSKEKYLKKKEAKFLKFITPIAPTTFNVCEYHFNKNPSRIRDLRVDTLSQMLTLGNIQQGGRYLVVEETSGLLTAAILERLGGEGSVLLIHDADSPPNLDILESMNLPEESIRQSVRHLNWVTIEEDFVNPPLKLEAKEGGENWKSHHERDKILKRKEQLTALENLRKDFFDGDFDGLICASQYEPYGIVDKLHSRLSGSAPVVLHHPHLAVLTEAHMKLRNSRNFLSPVVSESWLRQYQVLPGRTHPNMQMSATGGYLLHTLRVFDDPLAHSVKAVKRRKTSDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX5</accession>
    <name>I4YEX5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_36497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957189.1">
        <property type="nucleotide sequence ID" value="XM_006957127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX5"/>
    <dbReference type="FunCoup" id="I4YEX5">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEX5"/>
    <dbReference type="GeneID" id="18471965"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36497"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEX5"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="5">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="633"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="789"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1091" mass="126864" checksum="575211FE56FF4A69" modified="2012-09-05" version="1">MDQEYVAEALQPQERQRDADNFIPGSITRVVLHNFLTYDHVDFCPGPYLNMIIGPNGTGKSTIVCGIALGLGAGPKILGRSSDVNAFVKQDKTQGYIEIHLKAKNRHHNHVIKRSINSTDKQSKYEVDGEPSRLEVIKEIVSSYGIQIGNLCSFLPQDKVSQFAQMSPSTLLLETQKVAEGTGIGNLTEWHKKLIESGKTLNEAENDLNSMIKDRNDLEEMNKSQEREIERYRARKSIEKKIDLLNLMIPFSRYSQSKTQYDQAKANRKRLNENVIKIERENLPLKQKISDFEKLIKESEDKRKDNEEDIQRKRQEMKEVGKQLEQFVKHTEDATSKIEDAERADQRRLESIDSAKQNIAALESTIADPPNEEGLREFEDQIRTIRQSISELHEFGKKYQDIRREVASEKQEIYHEQSRYERILLSMDNVRQRRYEKFRSFDETTARTVEIINKNKDKFQEKVYDPAFLEVKVKDQSYAAAIESLINYNVMKTILCQNQEDYDIATKQIIDKYKFRVNIVQPVFSSRDTEPLMTREEIRQLGFDGFAIDFIDAPEFIINYLKKSCFLHKIPVAKTADQVNLKAIEESSAFKKRELRRYLIGTESHSYNWSRYGKQAASTTTTFVRPSRVFNDTNADIEERQELEARIEEYKRRASEQDQKIEELIPKEKDLHVQERTYKGEIQRLDEQKSEIQRKRQEYFKAQATLHSTKKNLQKLENMPSSAAEKQKYKTLICKITKQRIDEVETYTELVKELTQLIEKSELLVLEEVQYDANRRSLNGYLNGYNITLSEASRELSQADEHYKSVKAESTRYLKIAQNELAQASEELRNDFVKFRERVSQTGDEQSLEELEDALAVEKTNLEMNSNVSASIIEMFEHRKKVIEEQTQKIKKKQIQFDNLKASIDRIRSKWEPTLLKLIMAVSERFSKAFERFGCAGEVKLFRHATDYAQWAIEIYVKFRETENLELLTHQRQSGGERSLSTILYLMSLTELSKSPFSLVDEINQGMDSRAERLVHNQMVQVTCRDYSSQYFLITPKLLPNLTYHPKMKVLCVNNGEWLDEKRGNLKLLLKEHKDANAGIANGTQTLQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFA9</accession>
    <name>I4YFA9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006957254.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18472861"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56821"/>
    <dbReference type="eggNOG" id="ENOG502RWPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245252_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFA9"/>
    <dbReference type="OMA" id="QEMTHAL"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="729"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
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            <begin position="368"/>
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        </location>
    </feature>
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            <begin position="958"/>
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        </location>
    </feature>
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        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1116"/>
            <end position="1125"/>
        </location>
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        </location>
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            <begin position="1389"/>
            <end position="1398"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1515" mass="166470" checksum="271D7D329C3BA186" modified="2012-09-05" version="1">MNNEHMNPTQDPQPTRRRYTRALSLGSSLNSANSEKRSNVLGIHFSPQVEDDDIHEVSQPHPHRRSGSPLKGPRPPPGASAAGLPSSRDFEGQSVHTSRSNSPSKTVRIISPQSEALLSFHEQNPNKHQEHVQKRNEFEKAEAIVMERNPTNESEASVNFDAVNRKLGHMHIENQKNSDTGTPQMENSPKHPLRVTNPSASTTSLDATLGKQQKEEEIADEIGDENLKQEQVQEVEESHHSEQIKSDNKSELSHKSRKSDHSNRSKQTHKSNNDEQYSSVIPPRTSSKMGVDGAEQSFEEQKELPNDRDQIPVRKRSQTLPQNPRIQLQAPAMRVTQSTQPERSEGMVDKSKRSVSAQQQAVSSPSRHNTSSTRSPENASMLKYAHLDFLSKPPSSTEFPHAPKLNTRSGSNFSLNASSIGSNGVDIRSSRGMRGLAHAERGGGAVKFDVQKGGFVTPSNSSCSTQAGVIDPPSTRFDADAVTGKIGQVGQHNKKIQKARSQGDLLRQTTLLNTSTSPARTARELRAVLSGGSRFGSNSHQITLEQSRTRSRAEVDLVLDSEAVVEGGVLGGRMDVKLANDKVWWGNGKVRVVGFEDLQADETRHVFFHHDAPVDFYPPAGYGLPDDEGYYRGVNTKKGRRKDNRISLPFKIKLPIGGGAKGPLKSKSGFVRYIVIGSIHLKNHKSSDRSIAHFYRYVTIYPLLSPSSVLAPAPVPIMQTASKPLFLGGKGPINLTASVHRPHWVAGQRCYVMITIDNNSSKRVKSVSLSLNRTIIAYRPRPYASLMVGDDLDACQTTTNTKRIAEEKLEIGSKGTSGHVTAKGWFRGVDSGEQLEFSSSLQVPSDALTIPRTRLLEVNYTLRIGVAGSLSKGDVSVELPVKFINFLSIDPPPSAHPPTPMPMNSVSGVTPTDAELVKSAALERHKQDIERAKSPSNDVKTVDALRGTAKISPPALHAQSSVKAQTGNTVFNEGGPKISQMDIIDEALFNASVSRRGKGGKPPSPLPVDDMDTTAEQEQSSNNHDDSTMNETTQDMTEDSHMTDSQADGISEDEDDSGSEVSFDENDISEPAINVEPEEHNDGNEKKRPSSRPSLAESRRETLLNAIKDDDEDSASIDQNESNSNGEHEDIVEETPKLDIHSPTGDFHDAHDFEEEENEKQEASHAAPEDVKDEPEEVEIKVEEPKHDEPEIEPKGEPVSEQIKSEMEEPQQIHEEEELEESDEEEVEEHEKVDDDQSPPPVGLPQLAQDPLDHRSLAQSRASHLSGGDVMASMAYLSSPINDVEEPVQSVHQTARRPLPESPQSSSGKMTAHEQVNRNSPSVRSDEKSPSTRPEPKRTASEDPFSPTFMEQHQQKELPLSPSNKTPNSPSFWSPASKAAAAMPQLHPVKTDGISRNEEEAELETPTKVLNSTNEYSFDTFKRYAAAYTVPSPSAESDKSQPVSVKGRVAQFEQTGGGSNRSSINFEPSQLIKDRAVRRQLSALSKKSTDSLRPGSQNGENFNTTSMDIFNRWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ8</accession>
    <name>I4YFJ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_16718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
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        <property type="protein sequence ID" value="EIM22740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957168.1">
        <property type="nucleotide sequence ID" value="XM_006957106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ8"/>
    <dbReference type="FunCoup" id="I4YFJ8">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFJ8"/>
    <dbReference type="GeneID" id="18470703"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16718"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
    <dbReference type="InParanoid" id="I4YFJ8"/>
    <dbReference type="OMA" id="YPRFGEF"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
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    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="484" mass="55404" checksum="2BE69E3BF22194E5" modified="2012-09-05" version="1">MGRLSNIPVEELNNRIDGLSISNGSIENWAKTFVATPQRIFQPNIIEDVEYIIEAAFRQQIRVKPVGVWHSPSDLSCSDEWMIRMHKLAGVINVDTTNRQVTVYSGTLLREINEKLEENNLAMPILGSISDQTIAGCLATATHGSGIQYRSMSSYVRSLSLLLSNGDIVECSDTSHNDLFNATLCSLGATGVILTITLSVDEKFNLHEIVMPLSFDDYMSSEAEWLERWYTAPFVKAFWVPQANGISLSQSYKSFSDVFSTGNTLGGFLFSLVLQPLLLVKKYIPMIAPLISNLAWRYLFGSYSQRVDKSFNVFNMDCGLLQYTTEWSVPLSKGYKCLLELNEWLKYENDVDFPLEIRVAKSDDIFLSPANKITPYGQESHYLWIGVIKYKPYNCKVRYRKTFRKFEDILRKYNGRAHWAKHSTQTPQEVGEKYPLLNKYLDVIKTYDEEGMFINPFVERHLISEKNDNNSRDFKSYQVESHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFL5</accession>
    <name>I4YFL5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957414.1">
        <property type="nucleotide sequence ID" value="XM_006957352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFL5"/>
    <dbReference type="GeneID" id="18473629"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59922"/>
    <dbReference type="HOGENOM" id="CLU_534430_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFL5"/>
    <dbReference type="OMA" id="RSWKARI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="1">
        <location>
            <begin position="265"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="57749" checksum="06FDF9A35348DFAC" modified="2012-09-05" version="1">MPKQHIRTALLAAFNLRSLSSPWRNRLSKLLDEHSTKKRVMLYGKDTKKLTEALLIDPLTDDARSVQVLEQRYNLGGRRNQGELWTIKHNESISTPSTELVLIPLRALQDVDIVECLESLPEEEALDEAVLSHQLIIQSDASTSKLVDQFKDRPLTTLLDKNLNVADARKALDLLNDGDYNGYTNLMTSSNIQALKQDYRLTHNDDDRARHAIILALKDSNKTLDGRYQNTSEILDEERENITQIDTLYTKFLRQTPSLEAIQHDKEQSLQKSLEYFQKTPFYYLPIKADDVGASLEQSINSNFARSLELDLAAVDSQYNSTKSAAREISREHLTRAAEKGMTTAIASNKLEESIRNDDYKLKTTNICRAARKNLTTVGSIPDMIALMVEKSLTRSYVTVVASAGLGYSGMVADILSSGTAVGLTTLGAAIAVRNVQKMWKKAQKTFTESWDRAYKLIEFDYQETLQKEAKDGVLRDVKLSNQLTSEWVNTERERLEELNKEIETVRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG24</accession>
    <name>I4YG24_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_56593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956962.1">
        <property type="nucleotide sequence ID" value="XM_006956900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG24"/>
    <dbReference type="STRING" id="671144.I4YG24"/>
    <dbReference type="GeneID" id="18472828"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56593"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="InParanoid" id="I4YG24"/>
    <dbReference type="OMA" id="PNIFTDW"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="280"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="708"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="926"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="988" mass="113055" checksum="F6C43C519C9ACD2E" modified="2012-09-05" version="1">MVDKLNKNDKTKSSVKNEEETEDPLQASLMKLLSKSELYSKILQKKMNNPADKSKNDPISPPAAPKKEVKTTEPPQPPATKASRSTRATKSKGASPKPPAEQRKSSRQAGKFAEHDRIKREAEMRKEAHLAKQKRVLRERLKQREADGEVIIRRSSRKRPVVITDDEEEEDKNDDLPSDDATEVESDGGTVRHLNKRQKVQYKDDLESDEEENENESKAHRNENDDNDKERETFIISSSEGEDEDEEDEDEKITHYPGQPALVSGTELRDFQKAGVEWLSTLDSNGFSGILADEMGLGKTLQTITFLAQLIEDGNKGPFLIICPLSVVKNWIKEFNKFTPKLEPIMYHGDANKRKKIRQDMKKRGFFTPARYKQRANIRPKIICTTYEMIIRDTRYFRSIEWRYIVVDEGHRLRNLDTKLLKELRTIVSANRLIITGTPLQNNLRELWTLLNFCLPQLFDDLDSFQTLFNFDEVDENGEKDADKTAQLITTLHEILRPFLLRRLKADVAKTLPPKKEYVLYAPLTKKQKTVYDAILNRQIRSAILNIKTHGTLNAPQPKEDKEEEVLQPRTSRYRRTEGDTADQPKKDKAEGNNDNKIISIDDNDDEKIKKDISERDDDMDDDEFEQMIINEAAASALREKKASHHRRAMEAARTAARKEMGMMKFENLVMQARKICSHPYIFHWDLDENNERTIQKDLVNASGKLMLCMRLLEELIQRGHKTLIFSQFVSFLDILEDYLVDGLGWNICRLDGSTSQEEREEQIELFNEKSDDPDAPKVFLLSTRAGGLGINLVGADSIIFYDSDWNPQVDIQAMDRVHRIGQTRPVLIFRLITQNTIEQRMMDVAKSKRKLESMVIAEGQFKQDKKSAKQDAATSKALATQARLEFALKELDISAVKTVADDEKVISDEELNNLLDRSDDAMKRKQGWTHSEGTSNVAQVMGISNDVNHDDNMKVNDLDDQSARESSDLPSYVASVDPSRAVSESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG36</accession>
    <name>I4YG36_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_50458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956974.1">
        <property type="nucleotide sequence ID" value="XM_006956912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG36"/>
    <dbReference type="STRING" id="671144.I4YG36"/>
    <dbReference type="GeneID" id="18472526"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50458"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="InParanoid" id="I4YG36"/>
    <dbReference type="OMA" id="FEELAWM"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50626" checksum="B846B5348D328C8B" modified="2012-09-05" version="1">MNNLIRSSLWLGISSNSTKLVRSLTDHDFAERDAYFNRKGFHNHFIHGVYAAYSLGAQPKTIQRIADALASYQQPLRPVEKGTPINQSNWNDKQLLGKRDNYPTYLNYFREEVDKTKDTASLLDKYIYSRIANEVGVDMLSRFFSGLIHPIIHLGYALEFEHVDNKREVLAQALAWTATHPSDFSAVLPQDLWSNPEKENAQRKSSLQVYFDVLKDEKYSANSPDTPTLNHDFPVSATVKSAGGMLLEEASHFDLPASDIPKRQDELCRELAYTAMLMYASGGYKAGKKFKPEFILVHILNSSHFIPFILHYTPSAINKRLLLSAYFRVILTVYVSRGRPSLDAEVIKKREIPEDETNIWLGIVDDGLKQDDEHVLKAIRTLAFHDSKYSEDVPPEVSSVSLDGSIWSRVAHQHINAFKSGSAWSYERPGFEESWANDQVVYDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG70</accession>
    <name>I4YG70_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957007.1">
        <property type="nucleotide sequence ID" value="XM_006956945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG70"/>
    <dbReference type="GeneID" id="18474802"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62980"/>
    <dbReference type="HOGENOM" id="CLU_2172997_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG70"/>
    <dbReference type="OMA" id="DVYQYTR"/>
    <dbReference type="OrthoDB" id="10436280at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="120" mass="13258" checksum="CB8549DA8E170194" modified="2012-09-05" version="1">MDICVITKAGKMNGYIDLIISNLEKKEAIKVTSLKQGVSLEQSNALSAKLISVVEVAKRNFKPVHQYTRLVEHPQVRKTLSVTEILEGKSQMISPPATIEVILSSQPLALDESEGYSYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGF2</accession>
    <name>I4YGF2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957080.1">
        <property type="nucleotide sequence ID" value="XM_006957018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGF2"/>
    <dbReference type="GeneID" id="18474809"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63065"/>
    <dbReference type="HOGENOM" id="CLU_1541312_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGF2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="174" mass="18747" checksum="92D40E41044A94C9" modified="2012-09-05" version="1">MEKKEVESIPERSQTPPPEYEQYAGPSTSQPNNSQSSTGDVGFRSALGNSVKDNFVSRLRTPQEAGLIGSALSLTSATVGTTLGLTTAAIGGVLSLPAVAVGAGVKHHKNKQKQKQRESSSPSSSSSSLDNSNRDGSEEDLKRKQARELKEFKESQKREKEEWKRKGKGKDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGJ1</accession>
    <name>I4YGJ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957116.1">
        <property type="nucleotide sequence ID" value="XM_006957054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGJ1"/>
    <dbReference type="GeneID" id="18473546"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59769"/>
    <dbReference type="HOGENOM" id="CLU_2980854_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGJ1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="58" mass="6675" checksum="16D476FE91B8DD23" modified="2012-09-05" version="1">MHIYIIISSAIHSFTVHHLELLASICTLVCFFFWIALCGKIFHHQLSQLLVPHDDISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGK5</accession>
    <name>I4YGK5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957130.1">
        <property type="nucleotide sequence ID" value="XM_006957068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGK5"/>
    <dbReference type="FunCoup" id="I4YGK5">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGK5"/>
    <dbReference type="GeneID" id="18473551"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59775"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGK5"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="15628" checksum="C17787A074A9B0BA" modified="2012-09-05" version="1">MTTPTKHLASCIFCKIIAGEIPSFTLLSNDKVHAFMDIGPIAKNHALVIPKYHAPRFGDVPDEYASEILLAAKKVAKAIGCEEYNILQNNGKNAHQVVDHVHFHIIPKEGATDDSGLVIGWPAQGLSMDQIKEEFEKVKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGQ7</accession>
    <name>I4YGQ7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">WALSEDRAFT_59459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956545.1">
        <property type="nucleotide sequence ID" value="XM_006956483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGQ7"/>
    <dbReference type="FunCoup" id="I4YGQ7">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGQ7"/>
    <dbReference type="GeneID" id="18473364"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59459"/>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGQ7"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="178"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="398"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="398"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="437"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="576" mass="64322" checksum="A980947E9DA9ED7C" modified="2012-09-05" version="1">MSNPCHGNVLKDLHVRDADKHDALVAESETLPSVSLTERQLCDLELIMNGGFSPLEGFMNKKDYEGVVENMRLTDGLVFTIPVTLDLSSEKIKELGLSESSRVTLRDPRDENPLAIITIEDIWQPNKENEAAKVFGAGENDLAHPAIAYLHNNVKDSYVGGKVQAVNPPLHYDYVAQRFTPAELRSHFKKLAWRKVVAFQTRNPMHRAHRELTVRAARQRQANVLIHPVVGLTKPGDVDHFTRVRVYQSIMPKYPNGMAQLALLPLAMRMAGPREAVWHAIIRKNFGTTHFIVGRDHAGPGKNSHGKDFYGPYDAQELVTSFKDELKIEMVPFQMMTYLPETDEYQPVDEVPQGTPTANISGTELRRRLKTGAHIPDWFSYDSVVKTLRESYPPRLQQGFTIMLTGLWNSGKDQIAKALQVKLNEQGGRSVSLLLGETVRQELSTELGFSREDRHKNLQRIAFVSAELSRAGAAVIASPIAPIEESRKQARKTVETTGGAGNFFLIHVATPLDICEKTDRRGVYAKARKGEIKNFTGVSDDYEEPKDADLTVDVAQQPISEIVHSIVLLLEGEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGS0</accession>
    <name>I4YGS0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956558.1">
        <property type="nucleotide sequence ID" value="XM_006956496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGS0"/>
    <dbReference type="GeneID" id="18474758"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62539"/>
    <dbReference type="eggNOG" id="ENOG502SY06">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617067_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGS0"/>
    <dbReference type="OMA" id="GNDSHTH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="444" mass="48926" checksum="8248149815BB8A57" modified="2012-09-05" version="1">MNNSDAYFGYDNSLDNHLNTEEANANLELALKFVQSQSGQVDNGNEHSFPTEQTQFDQEQVSNLLNQAQQHQQQRTGSQSNDDEHSDYYQEDEDLPRKRGPGRPRKSRGLDDDGRPPRKARAPRVRDEVSKSTKGKYALLRDKAEVDEDKRYLDEHHGIVMTTGQAVLQSHISRILLAKISEAGIGQASGEAYGRLPNGFTANPSTWLEPHGCDISGWPDGLPPTAIGGWTNHQLYAVLRLLLEDPNNITIYRTDGKPAIPPRPFQGKRRSATVSSNSPARKRTKKKASSVKMEDTNSLGVGTSSAEADAQAAAAAAAALQQQQQHFHTGEPSTLDLDHRSSHLFDIQFSHNGHSNPDVTTENHLANLVEFAQSHSANNNGQALQFINKRNNDSVVDEHGGHHQHHHPDPEALAEISRAFSIEPSQGNTSPSQSSFQMSTPDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGS5</accession>
    <name>I4YGS5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956563.1">
        <property type="nucleotide sequence ID" value="XM_006956501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGS5"/>
    <dbReference type="GeneID" id="18474760"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62543"/>
    <dbReference type="eggNOG" id="ENOG502SBKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428746_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGS5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="91" mass="10439" checksum="A83E9109160A1827" modified="2012-09-05" version="1">MVGIEELNPCAVGSTVEWRIKENKGGPSNETTNRKMDQYKKLKENGMHFNDKLQQSQQFHNPHINAKLISWVGVDEYASNQPNNANVQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGV2</accession>
    <name>I4YGV2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_31354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956588.1">
        <property type="nucleotide sequence ID" value="XM_006956526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGV2"/>
    <dbReference type="FunCoup" id="I4YGV2">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGV2"/>
    <dbReference type="GeneID" id="18471287"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31354"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGV2"/>
    <dbReference type="OMA" id="MTHTYKF"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="74" mass="7776" checksum="F4C2044AE202BCB1" modified="2012-09-05" version="1">MGSYKFDVVMSCGGCSSAITRALNKAKEDPNFGISDFKVDLESQTVVVDGSASLKDVEAKIAKTGKTIKSSAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHA3</accession>
    <name>I4YHA3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956729.1">
        <property type="nucleotide sequence ID" value="XM_006956667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHA3"/>
    <dbReference type="STRING" id="671144.I4YHA3"/>
    <dbReference type="GeneID" id="18473428"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59571"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636482_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHA3"/>
    <dbReference type="OMA" id="WEADSAV"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="410" mass="47770" checksum="629D9AA67BD7B7C7" modified="2012-09-05" version="1">MSKNGEDAPKTQFRRLRPTDNISNNRRAHQRTLSSQSSPIASPSTAQISQIPKHSFNRSISTVQQPSTSSSPIPDLNYQIYAKSRSPSFTSTFSMSSMLGNRRTPYRVGFQPKGVTRDRIQDFTNERDKHKRDDKDMLNDRRLMRRLDKLFEVHNKHNDAFGLLSDIRLRSQEQNVVKWEDDKAVQWCPIAHVQFNPLKYRKHHCRMCGRVVSAAVVEKDPIKRRASVVMTKDPSGKIRMCRLDEEITGIRVCLECWKVVERQEMRVFIPRYMRAYKEAILLEKELNDKIKGDAIATKELMAKTQRLEYLIKEFDEPTALCRAISTKFKGSLGIYMGLLKRQVEKERMAAKAREDESKLDDSDDSKLQALFEQQSQLLQQIERTKEARKFEDVRILTENLEFVNKLIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF7</accession>
    <name>I4YHF7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_8537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956491.1">
        <property type="nucleotide sequence ID" value="XM_006956429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF7"/>
    <dbReference type="STRING" id="671144.I4YHF7"/>
    <dbReference type="GeneID" id="18475841"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_8537"/>
    <dbReference type="eggNOG" id="ENOG502S1MF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070890_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHF7"/>
    <dbReference type="OMA" id="HEFSSHI"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="242" mass="28232" checksum="B5C0FF55C80EBBFC" modified="2012-09-05" version="1" fragment="single">ISRPTLEIVYSYYDEDLDEFSRFSNLVRQKLHWKFRITDTVYVKNEAHSPILHKQLNKIVDNVAYLPNIGREGATYLHHITQRYKATIFPDDLNNQTDEILADKTLFLQPHPAWHWIMYDRLDHINVDTGYISLGPYVPGSCGVSEGHTLPQMKTIWQLFTNTECPEDETQLVTWAGQFMVSQDRILNNPYSKYADILSMLEAPADDPIHSETPWWFMSKNDPSNPFIGHSLERSWPIIFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF9</accession>
    <name>I4YHF9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_15571</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956512.1">
        <property type="nucleotide sequence ID" value="XM_006956450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF9"/>
    <dbReference type="FunCoup" id="I4YHF9">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHF9"/>
    <dbReference type="GeneID" id="18470667"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15571"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHF9"/>
    <dbReference type="OMA" id="SWSVDIR"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26363">
        <property type="entry name" value="Phospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="33635" checksum="7D541475FF607EE6" modified="2012-09-05" version="1">MGIFDDIPVEMPDVTDRHTLLQLAQMTSNAYIKQGSDEWIEPSKHFSGEVISFGWKKDDDGLRGHIFSTPDKKTVVIAIKGTSAGLIGGGGPSSKNDKFNDNLLFSCCCARVSWTWTPVCDCYNGGWQCHEECLETSIEKESVYYPVATNLYNNVSYMFPDSNIWITGHSLGGALASMLGLTFGVPSVTFEAPGDRLPSQRLHLPQPPAELSGVYHVYHTADPVAEGTCNGMLSPCNAAGFAMETRCHTGLSIVYDTVSKFGWAVDLRHHRIATVINEILEHEWKDDDGVVYVPKPEAEGLWAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP5</accession>
    <name>I4YHP5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B-block binding subunit of TFIIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_31019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956165.1">
        <property type="nucleotide sequence ID" value="XM_006956103.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP5"/>
    <dbReference type="GeneID" id="18471231"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31019"/>
    <dbReference type="eggNOG" id="ENOG502S1RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248455_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHP5"/>
    <dbReference type="OMA" id="THCISEE"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="143"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1352"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1293"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1327"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1352"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1506" mass="171613" checksum="448BD0A0FAECC14A" modified="2012-09-05" version="1" fragment="single">MIAADVVVHNVLNEISVDGDWGSDIQTLVKYIKAQLDPSVDINNGPLLEFFWRILTQQSSFQIGLATEQLKLALKEKAPPISSKDGNQVIMFELLNFDDTQTSLASLLERYGNDIRVRTDSDMNWFVITGLNHKPAKLSQMVLSVLTFISRSRENGITFMQISKMTGYDSKTVFYCVKILIELDLVVKMHTVYRGSTTNVAIHRKFLASSPHYRAHALTEAEPAKNDSDNEAIDFEETVQGRDASGLPEFSELSKEHLTNNNLLKGRILKLINSCPNKIIQHKYIFNKIGFKTNSKPIQRLVARLIGRMVAEGSLEKCATKVGGRDTRVNCLRIADDDNGSKSSEKVIEEDMIKLESDDEDDDDDVVSDNFGAGIAITVEKQILNLIHESGIEGMTISSVISALPTINRRTVENILLRHETDHDPASLTDLALKSTTEMNGRERRQRFFTRKNYILLAEKEGLDIPVEDLVSDQSGSLNVINSALGCSSRQEYQASATRMIGSIGGQVATPKKLGRPPKAESSKSAMPTPKPKGRPRKSEASQTPSEVPKKRGRPRKSEIIEDQPKKKGRASKNTIEINDDDDDDEKTVKDVTKKHSELQENVSESIPLNATPEETQPPSEVSLTTSQTAPQRAYHNPELDMVGDDNSHMSTPNKRQQLNTQEVAHNTINVTNDVDKDSYLKKRKLRSRKSGIAPILIDVEDVSQDHISTKRKRVQSPQDSDESDAYEPGEDHDEKEDGTSENQGVEDEKGNIQEPQPKVITEVENQVNKLQYDTSQQQNASEINELDVKRDVDTAISDNQMESTMTSTSKLANGIPRSKTTKKAIQQMRASRTDLSQHRRIQDLYNAIKGAGGMVEAVRELFDVYQKYVHGPNHETAAQIDRPVVRKTLNVLFNEGKLKETKVSSRTYGGASMQKRLIYVSDIDTHSEAFRKKKEELGQDLMKRYQPKASFKEVDTENIGYINFRRKYAADNLPENCTDPSQKENIRNLILSDVKAMARLHGYMTGRFAKAHTLYSLLSQEMQQKDQLSSKMSDDEPIVCMNYFKRDIPLNMYMKLIPWTTFDEMAFEYKNDPSKSKLRIKDLPEHLQELVSLSFSKRRHFITECVRILWHLNLVELMEEIEVTDEIVTDVSNLKGVRELKTPNRLLYFRLKKDGLFLSFEDKPVLIDGMTLNTNEDIDKYFERLKVLALSSQDASMTANEKSKNPDMTNFSHFASYIQKHQSWQNDMMLSAMQKRLLANYTGKRSDIPRPGTEEEYKEIAYTCGAPLPLVKRYIEEETSKQEKLKLGVTLHRPKKNKNTTKKLKKSSKYSRSIDAKVKKARSRHMRSEESEKDSFEDAEDAAIVEQIREFRKKNEKKKKSKPTKENPYRLDPPLSEPPGKSPEELIEEHKRLFPEGTSARQTKNYSYWNPETDELLRDSIAIIKARTRNHKNPSLSAALHVFPRFKTGQLRNHEKTLLENREEHVYIERLANEYESLCKDLVKEKKMEKNRSLSLDKIDFIEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE2</accession>
    <name>I4YIE2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956399.1">
        <property type="nucleotide sequence ID" value="XM_006956337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE2"/>
    <dbReference type="FunCoup" id="I4YIE2">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="GeneID" id="18473318"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59370"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860831_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIE2"/>
    <dbReference type="OMA" id="AFIRWTH"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="30202" checksum="1E9FEB506B4BBFB0" modified="2012-09-05" version="1">MPICVNCRQYLENVATIYSFTDSRIELCPACSNLSDVYIGSRNLSLLSDLVLLKPQVLRHLLYNRRAEPAQSERFRSLNPGYRHNNVNTTTHLVKLGGILVIADAFVSWVHFRADGMSFMKLLIAATLDALSYHIAVIFAVRILTVRSVSNLQISLAIFYSSFAKLFLLLLLIIADPVPQSSSTVSNVPDNFLTGMHLTDDNRKAVWNVYTSLDDDRIDRPWIVNTVVGGMSAGFGLRVLLNTPPITSTIIILSGWIARSVTLELLHMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL9</accession>
    <name>I4YIL9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956474.1">
        <property type="nucleotide sequence ID" value="XM_006956412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIL9"/>
    <dbReference type="GeneID" id="18473350"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59427"/>
    <dbReference type="HOGENOM" id="CLU_501737_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIL9"/>
    <dbReference type="OMA" id="CEYASAE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="543" mass="60364" checksum="7D8C65B3F7396CBC" modified="2012-09-05" version="1">MTDTTQVKRSSHNSFKNLFTKASNSTLNKRTTLPSSLPVSVNRRHSASNYPPPYADVTPAKKFSISSSVRTSNTTPHVPKRTTSLYQPSETFLNKNAAMSRSTIPDSQSNDDSLQDIKATFERMKDYLASRDSLSSVSSDLTTPKPSVLGSKHMAEKTQFNTSNKGGITHHTSPTVESLAVTIEEPSFEEQSELDREYEALMDRQNLLPRSASTTVALNPSIIVDEPEVITPTPRSNNYSPLKMPDAQLEMETSTPTQCTNKRMSMPANLPSTQHHDERRSLTYPEGYSNLSRSRMSQQQQQSQLSSSSLCSAASMTSPITNTMYGSPGLMTPSTSTTSIGGAGNGDTSLNLHRLSKQELFRLLVDTQSDFHALKSRYGLEKGALEDQLRDTLEEVDNLVEENEVQKQDLAKEKQYVAALRRALHRDNDGVVYELERSFNSIDELKGLVDRQQAVIDEQKDVINRYKSLDDSVRFPNNTNIQTNKSNLLGDVTAPFLQQSHPDDTSFISQQSDLIVDIDSTVHDENGKWTLGLDDDARRALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIN3</accession>
    <name>I4YIN3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_50145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956488.1">
        <property type="nucleotide sequence ID" value="XM_006956426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIN3"/>
    <dbReference type="GeneID" id="18472516"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50145"/>
    <dbReference type="HOGENOM" id="CLU_162195_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIN3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045992">
        <property type="entry name" value="DUF5948"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19373">
        <property type="entry name" value="DUF5948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698976" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="96" mass="10636" checksum="4FD469589E70B12D" modified="2012-09-05" version="1">MKLSVFSTICVVPFAILALINSASADHIGGCTKSDNSYAPYWTKECCRIAADQYSIPYGYSEKYGDCRSSITADNRLNGKMFSKCCSNRDLGYYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP2</accession>
    <name>I4YIP2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">WALSEDRAFT_66740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955681.1">
        <property type="nucleotide sequence ID" value="XM_006955619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP2"/>
    <dbReference type="FunCoup" id="I4YIP2">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIP2"/>
    <dbReference type="GeneID" id="18475140"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66740"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="InParanoid" id="I4YIP2"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="363"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="542" mass="59235" checksum="64F08D20BBA4B46E" modified="2012-09-05" version="1">MISKRAFNLFSKSATISNQPYDILIVGGGPAGLALASSLGSNDSLKYLKIGLIEANSLDNVRTYNSNGLSAYSNRCSSISASNFNNLKSIGVLDGLDLSRVSPVNNMQVWDGRTDARITFGRQIDDEDLPLIKDNTTLSYMMENTNLQHAFLKHIEGSTSIELLESSKISSIERDNEWPRVQLENGTSLRTRLLIGADGFNSPVRKFASIDSFGWAYNAAGFVSTLKTHPSNTISHSSRTAFQRFLPSGPIAYLPLPDRSASMVWSTTPEMAKKFKQIDSRVLVLLINAAFRFSDDVLKILYSKIDLEYDSFFSLIKEVEIAEGIDMTTSRQISELSNQDGIPPSDHELYPPLVTSIEEGSQASFPLKMNHVDGYDASRVALVGDAAHSCHPLAGQGLNLGLADVQSLTSVLSEGRRYGGDIGSKTVLERYTRDRYIQNMMMLSATDKLNALFKVNDGNPLVELRSIGLETLNEIDSLKDLLMKQAGTTGNFEDSGRGSRGVNFIADGIEGVGKAVNMFSAVARQLGNIGEAKIAEIVDNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIS7</accession>
    <name>I4YIS7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_30707</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955713.1">
        <property type="nucleotide sequence ID" value="XM_006955651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIS7"/>
    <dbReference type="FunCoup" id="I4YIS7">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIS7"/>
    <dbReference type="GeneID" id="18471165"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30707"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_2_1_1"/>
    <dbReference type="InParanoid" id="I4YIS7"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="353"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM23869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="703" mass="76581" checksum="386CA337D8E64E8B" modified="2012-09-05" version="1" fragment="single">MSKHIRDTFTECHKKGRPAFVTFMTAGYPYKNSTVDLMLSLEKGGADIIELGVPFSDPIADGPSIQAANTVAVSNGITYSDCLDYVREARSRGLKTPVMLMGYYNPVLSYGEEKAVKDAKDAGASGYIMVDLPPEEAIKFRNICTSEGLSYIPLVAPSTTEARIQFLASITDSFMYVVSKMGTTGSSNQVSTDIPQLLARIRKYTSNPLAVGFNISTREHFNFVADAGSDGVVIGSRIINLVRDAHKEGKDINAEVENYCAEICSRDTTKKEAPPVEVPTERKEAEQPTVPNMPEPLLDAMSGNPARFGQFGGQYVPEALVDALAELEAAHKMAVNDPEFWKELESYYEYMGRPSYLYEATRLTEEAGGARIWLKREDLNHTGSHKINNAVGQILLAKRLGKKRIIAETGAGQHGVATATVCARFGMECHVFMGAEDVRRQGLNVFRMRMLGAQVIPVSSGAQTLKDAINEAMRDWVTNLSSTHYLVGSAIGPHPFPTIVRDFQHVISKEIKKQILEKTGKLPKAVVACVGGGSNAIGTFHDFVPDKDVRLIGVEAGGDGVDTNRHSATLTLGKPGVLHGVRTYLLQSATGQIIETHSVSAGLDYPGVGPEHAHLKDSGRAEYTVADDEQALRGFRMLTQLEGIIPALESSHAIWGGVELSKTLNKDDNIVICLSGRGDKDVEQISELLKTGWDKRLDWDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB2</accession>
    <name>I4YJB2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955884.1">
        <property type="nucleotide sequence ID" value="XM_006955822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB2"/>
    <dbReference type="GeneID" id="18474692"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61883"/>
    <dbReference type="HOGENOM" id="CLU_2335241_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJB2"/>
    <dbReference type="OMA" id="NQFKCVK"/>
    <dbReference type="OrthoDB" id="3352118at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="10637" checksum="6CD5439D1AA97C17" modified="2012-09-05" version="1">MSANAKGDVISEYVDGGSFSRNKLVNSREHLFGSLDETKPGILPEKFPKPTLSAAELKALNKEDIKTIIDATGYSESTAQSKLNQFKSTKAVVSDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJD6</accession>
    <name>I4YJD6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_30824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955905.1">
        <property type="nucleotide sequence ID" value="XM_006955843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJD6"/>
    <dbReference type="FunCoup" id="I4YJD6">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJD6"/>
    <dbReference type="GeneID" id="18471195"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30824"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="InParanoid" id="I4YJD6"/>
    <dbReference type="OMA" id="ATLKFEM"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="108" mass="11801" checksum="4EA5048EAE998F85" modified="2012-09-05" version="1">MPATLETIRPGDGVNKPQPGNTITMHYHGTLEDGSVFDSSYRRGQPFSSPIGVGRLIKAWDQCVPQMTKGEKAIITATHDVAYGETGFPPVIPARATLKFEVELIDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJI5</accession>
    <name>I4YJI5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955953.1">
        <property type="nucleotide sequence ID" value="XM_006955891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJI5"/>
    <dbReference type="FunCoup" id="I4YJI5">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJI5"/>
    <dbReference type="GeneID" id="18473177"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59108"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="InParanoid" id="I4YJI5"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM24127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="566" mass="61431" checksum="5966715D2FBA3F26" modified="2012-09-05" version="1">MSLPGMMQPPIILLRDGTDSSQGKGQLLSNIGACLAVVDCVASTLGPRGMDKLIVSNRGEATISNDGATILKLLEIVHPAAKSLVDIARAQDAEVGDGTTSVTLLAGEMLRECKSFIEEGVNPYIVIKGYRKATQVALEEIKKLAIPIDKSNPEKFREHLLKCAATSMSSKLIQNDKPFFTNMAVDAVMCLNQDDLNEELIGVKRVPGGGMQDSLLINGVAFKKTFSYAGFEQQPKSFTNPSVLCLNVELELKAEKDNAEVRVEDVNEYQKIVDAEWDIIYQKLDAIVKTGAKVVLSKLPIGDLATQYFADRDIFCAGRVASDDMKRVVQALGGAIQSTVTDIDPSKHLGHCGKFEERQIGSERFNIFTECPASQTCTIILRGGAEQFIAEVERSLHDAIMIVRRTIKHSTIVGGGGAIEMELSKRLRDVSKSIQGKQQLIISAFAKSLEGIPRQLCDNAGFDATDLLNKLRMQHAKGDLWAGVDIENEGVGNSVELFIWEPALVKMNAIASASEAACLVLSVDETIRNPQSEAPNPSAPIDRQTAQSAMRGRGGMRGGRGRGRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK08</accession>
    <name>I4YK08_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_56076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956112.1">
        <property type="nucleotide sequence ID" value="XM_006956050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK08"/>
    <dbReference type="GeneID" id="18472767"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56076"/>
    <dbReference type="eggNOG" id="ENOG502RYU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652475_0_0_1"/>
    <dbReference type="InParanoid" id="I4YK08"/>
    <dbReference type="OMA" id="YREYNEY"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052005">
        <property type="entry name" value="CDF_SLC30A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531:SF1">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="124"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="421" mass="47472" checksum="2768BEA46C6D026C" modified="2012-09-05" version="1">MPILNKKSSIKFTPPGQTRLPNLDTTPSSEKPSRRKHHHKRSLSHAFFSFNDPTVTLNGVSTAKGSAQTSPTKLHSNFAKGKPSKPAPPLTFERSAFSGKKLTFTTFEFVLGCWLWLTGQRCDSLATTGMGYLITFDAISLLSINAFDYYRTMSPSHKLPFGIRRLETLSLFTQVIYLVFTVTYLAKESIEHALISSSEDDYDHQYGIPFPTHSILLSAFLPYFANKYFNNHHALATVTGTFFYNPKQRRTSKFMNNPFSFFLTLFGGLLWLTDELIEPRYHHFFDKFLACLQTISVGWLVYPSLICLARVLLQTAPSSASSQILRDALKEVGSHPRVLQIELPRIFQITPESLSRTLLDEDSVDLTRLNKSGSSFISVKVLVDHDTTDIEIFNLTQLATENILSQFTASGTQCTIDIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y521</accession>
    <name>I4Y521_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_49594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960896.1">
        <property type="nucleotide sequence ID" value="XM_006960834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y521"/>
    <dbReference type="GeneID" id="18472504"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49594"/>
    <dbReference type="eggNOG" id="ENOG502S6ZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212881_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y521"/>
    <dbReference type="OrthoDB" id="7118285at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="49" mass="5685" checksum="BA6279483E813582" modified="2012-09-05" version="1">MPRHLISDAHEWINEIPTVPIYYLAKPQRGERATQNQRGKKTLLSLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Z3</accession>
    <name>I4Y5Z3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960535.1">
        <property type="nucleotide sequence ID" value="XM_006960473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Z3"/>
    <dbReference type="STRING" id="671144.I4Y5Z3"/>
    <dbReference type="GeneID" id="18475766"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70618"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Z3"/>
    <dbReference type="OMA" id="HQYLEFQ"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="440" mass="50048" checksum="0472CC71E5AA2F4B" modified="2012-09-05" version="1">MNDNKFDFLIVGTGYSESILSSALSSAGYKCLHIDKNDYYGDNWATLPITELDSSTIKINNLKNPNKFLISRHPSVILTERGKSNQLDTILKSSVFNYLSFKLVDSLIHYNDGEFTQIPKSKQEVFKSTISLKDKRMLMKLLQWIASREFLKEENMKLSEYKPEIPISLFYSLIYSFGMAINLDEDTHSAFNRMSTFMNGHGVYGPSCFLYSQYGGVGDIIQGYCRSSAVHGSTFILNHALESLEKCDSEYSVRLHNFEETFTVKKVISNAKNLYLNQPSRVINKIGRAVMVLNMPPNVDPLPESPILGYPPMAFGIRNAVHVHWQSSTSGVCPPGYYIVYFAATLSDNEEATLDELFEGYINSLTTSREDIEFLMVYVEEEREIDVKTDVELIKQEPTTFAPFVEPSEKAVEEASRVFELLTKREATEMFATTREKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y612</accession>
    <name>I4Y612_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_34071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960554.1">
        <property type="nucleotide sequence ID" value="XM_006960492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y612"/>
    <dbReference type="FunCoup" id="I4Y612">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="GeneID" id="18471808"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34071"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="InParanoid" id="I4Y612"/>
    <dbReference type="OMA" id="AYRWYLT"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="129"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="575" mass="63295" checksum="756A956156BA487A" modified="2012-09-05" version="1">MAEEEKPPIQHSVSIAQESPTRTVSVNRNRSINRKGSQGSLYPVPTNESLKGLRRDSLPLPTASAEITGATDLVLPPNVAFGKDLERGEDDIDEDAGEAVKEEKEDPYLIAEFEEGDPRNPKNWSSAYRWTLTFIGGLLVLNSTFSSSSPSGIALNLMQEFTFSREVATLAISLFVGGYCIGPLLWGPLSEGNLGRKWTLLIAFFPYWMFTLGCALAPNTAGILIFRLLAGCFGAAPLVVCGALISDLWDPKRRGIALSIFSLAPFAGPAIAPIVSGFISSSGADWRILFWVLFAFAGSCTLIIIFILPETYAPALLSQIAKKKRKETGDDRYKSPLDLRKRGFKSEMQNTVFKPFRMLILEPMLLSLTIFMSVVYGVLYLLFEAYPFVFGPGGHNFNEGIQGLMFLPLFIGGFIACLINVFYFNPKYIKAVEKHAPKLPPPEIRLEQGALGGILFAIGFFWFGWTSYPSISFWSPLIAGGLIGMSILFVFLALFNYLIDTYLWSASSALAANTIVRSAFGAGFPLFASQMFEKLNPRWASTLLGCIAVVLSFIPFALMKYGSYLRTKSKFAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I2</accession>
    <name>I4Y6I2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_66210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960372.1">
        <property type="nucleotide sequence ID" value="XM_006960310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I2"/>
    <dbReference type="FunCoup" id="I4Y6I2">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="GeneID" id="18475095"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66210"/>
    <dbReference type="eggNOG" id="ENOG502S3BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1741992_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6I2"/>
    <dbReference type="OMA" id="CQMERRQ"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="17808" checksum="F39F9FD425AEEEFE" modified="2012-09-05" version="1">MSDAPETVKIDNTPPPGQSYDKYKKAFEMISLDDVNRIENVPCMRNALLYGIGGGMAFGAIHFISTRRIKSSWNWTFASAMVVMVGTWQHCRSRRTEEMDKMRQITEKYSDHHISNLKRKNDEARRQFKERKEQEERVQYSWYNPKRYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K1</accession>
    <name>I4Y6K1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_41165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960391.1">
        <property type="nucleotide sequence ID" value="XM_006960329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K1"/>
    <dbReference type="FunCoup" id="I4Y6K1">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6K1"/>
    <dbReference type="GeneID" id="18472204"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41165"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094004_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y6K1"/>
    <dbReference type="OMA" id="QCRFAVY"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16184" checksum="135ED19B02CD74AC" modified="2012-09-05" version="1">MSSGVAVSDECLTAFQDLKLGKKYKYIILKIAEDGSAIVLDKTSDNQDYDAFLKDLPEAEPRWAVYDFQYQKGEDGVRNKILFYAWAPDNSKVKQKMMYASSKDALRAKLQGIAFDIQCTDESERACHGQGFKGSLKTREYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-01-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6S3</accession>
    <name>I4Y6S3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960327.1">
        <property type="nucleotide sequence ID" value="XM_006960265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6S3"/>
    <dbReference type="GeneID" id="18473043"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58638"/>
    <dbReference type="HOGENOM" id="CLU_1416173_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6S3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="1">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="192" mass="21136" checksum="1054FA9313FCB58F" modified="2012-09-05" version="1">MQKRLGLASCCFGQFANVAKRSENQAGAVDTHSVIQSRARDLPYNYRYGQGGLSRAWYDGIPNHASTALGINAGYNTLRQFIVDMITVANKDNRCNNDPFYDATQRTGLKMCIIDEGSCATTAEYETIYDGVDATLSYLKEQGCTRCCATLSHGGKWKATIKTTSDCSSGVKHSCKTNEHYDNACRVVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6W0</accession>
    <name>I4Y6W0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960210.1">
        <property type="nucleotide sequence ID" value="XM_006960148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6W0"/>
    <dbReference type="FunCoup" id="I4Y6W0">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6W0"/>
    <dbReference type="GeneID" id="18474463"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61323"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013085_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y6W0"/>
    <dbReference type="OMA" id="FKEPRGA"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="496"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="585"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="643" mass="67853" checksum="2B497214B3CD0F3C" modified="2012-09-05" version="1">MSLFIHQEVSEAHDKVRQPLSRTDWILLGPAQDGGLKLQSEGAGGLEEIEEEFHDGRIQFAFVRVKDPNSQLPKLVQINWCGESVPEFKKGGFHSQLNQLTQLLSGAHVTINARSQEDLDPDAILKKVSDSSGSKFSVNQSAPALSERPVAPAPVGTAYKPIGTPDIAAMRSNVPKPEAPTPVGTAYTPPRNELANIRQTPPVPQQAPAPVSVPPPAPAQPSIPTPPTQAPKPPSGGLFGGVVGKAGDWSVPKSSPVNTAPAPVPAPAAPTPAPPAPAQSEPEERPGKVGTAYEPVKLPAPKKLGNRFPFAQGTETSAPPAPSSFGGSAPPKKLTWSERQEQARKQAEEEEARSGNALSNASAFQSSAPAAAQPPPMPTSTRPTPVVDNSAPPPPPPPMPSRPDAQPETRAVPPPPAPPAPPMPQSSYEAHSGLGQSPSQEALIQSEMEKLQVEDETSIPPPPPAPPAPPMPAAPVTPAAPAAPVAPPAPAQPQSKGGQRAKVVYEYEATEDNEMDLIEDEIIHDIEQLDEGWWSGKARNGREGLFPANYVELIEEEEIQEAPASASIPPPPPPPPMPARSTSADQGKTAIAEYDYEAGEDNEISFAEGDTITHIDFVSDDWYEGTSKDGKRGLFPANYVVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y713</accession>
    <name>I4Y713_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_30194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
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            <begin position="314"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="41"/>
            <end position="206"/>
        </location>
    </feature>
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            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="41"/>
            <end position="65"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EIM19755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="42675" checksum="E6E1479DAF7477D8" modified="2012-09-05" version="1">MTESLDQIIAITGADRQVAEQLLSATNGDVQSALDLFYSDDASQSRVAEQQHEQQSAQGGPTTLSGAPADPLPDGWGQPKKTTNKGKKAGGIATLRDFNKEQESDDDDDPRKRENLYAGGERSGLSVQGPSRGGPRGPNDIVGDIMKKAAESNEEAADEFAKSNNETTNVFSGRGNRLGSEEDPAESNQAGSFETDDDWEEVDDEEPVNRSLTFWRDGFSIDDGPLMRYDEHQETLDALNSGRAPLSLLNIRFGQRVNLGVSQRTDEDYVPPPKVFKPFEGSAGQRLGAPTASIRTQPVPSATNTTSDKVEVDESKPTTRIQVRMSDGSRHVVKLNTDHTIEQLRQELQSVEPSLRGIGYELTTTFPTKTLTEGELTIDEAKIGGGVVNVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y767</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">WALSEDRAFT_61290</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006960081.1"/>
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    <dbReference type="GeneID" id="18474443"/>
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    <dbReference type="eggNOG" id="KOG1817">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        </location>
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            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="255" mass="28846" checksum="073626692FFE4ABC" modified="2012-09-05" version="1">MQYNRVSDGNLRGITASENVYVDDQQRIKPIYDNEVSEFVGDSILGMIVTLLLRQWYPHLRPNSLSEIRSHLVDKARLSDWAKMYSFDMHLNLPPSQSQLAIRLSPAVLCGTFEAYVACVFDQEQDEMMGMMAVKNWIEPLCKPYADMYNVDITNREKEFRETPKLGSLSYLNQMMVKSNLNATWNEAGGYDAITRTQSNWVETLTLTLNSNSQGTSNHGFNTDFPATFTGSSSKKKEAKEIAAFKALKVLGINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y778</accession>
    <name>I4Y778_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960154.1">
        <property type="nucleotide sequence ID" value="XM_006960092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y778"/>
    <dbReference type="GeneID" id="18475718"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70339"/>
    <dbReference type="HOGENOM" id="CLU_064800_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y778"/>
    <dbReference type="OMA" id="LEIWIAY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39845" checksum="3E8032BB15F85B8D" modified="2012-09-05" version="1">MESILEPAETRYLWVYYIFQLVASAGHLFLALLTIFSRQIAGNGVMLNFYGIFSVTLFFDAILLYTGHIYHKTDSIPSSIRIINASIRMSGMLANACTTLTVVMRVFTSVNAALGTPLAKYLVRITDTILIIIPWTVSVPFLIAYLVQTISNPEKVVRTKYFCSFEGATITEVTSNLTLALMSLLLVLAVLTAVLLIRLRISQHGLVYINTSTDLVIGCRILLFGLYSLTTVTILSGTLNHRWSGFSDGPTLTFALTGFWAFLLFFIQPDTFDALKTCFGLRRKHRRPSFSSITASRPQQPMEFSPVGSPMLSPTLGEFGELRSDDFSLNNNKMGTWSSVPRVHHRERSIDRIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y793</accession>
    <name>I4Y793_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960169.1">
        <property type="nucleotide sequence ID" value="XM_006960107.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y793"/>
    <dbReference type="GeneID" id="18474449"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61303"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002116_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y793"/>
    <dbReference type="OMA" id="EEVWERD"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="858"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1075"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1356" mass="151346" checksum="01B5EEE547BE0106" modified="2012-09-05" version="1">MEIAIGIAVHDFEPLERDPSILSFKRNDIVHILNKDASGWWDCEVNGVRGWLPMNYVTEDIDAFYDNSEDEQDHSADEQDEEDIKDTLDKALEEQNQPHKESPIVAVRNALTLVKSAVISSRLAHLQPATACVISSVRALLSAADALNKDSSSNKISASIADNRRNLLSLLSRLVVQSRLVMKEALQSSNKVILNEDLEEVIPMADQVLVLAENFVKLCESYGINLVEDITPHSSPHMSQLSQLSPKSQRSMSSNNNQKSLMHRQASRLSRMTSYDSFKSSAAQSVASSAASLVLNNSHDWADSSNEDHLEDQSSSDQTFSRLLCVINDALKSTIAAALGHIHAMPNENHATASIHLIDLLKETIAIVKRLLTVLQSIQQNGPLNTVVPRDGMMLDETIRLTYLSTDDLVAAAESLLFAKPRRSMIDTTQESKRHHLLKCIMQIHKISTEAFEISSRMIEYASTASIPLSLNASIPSQQSTFSLQDITNNGCNQPIPEPALQPRENQTEFKRQHRRQQTLSLFDRRAASLTCLKDQFQGNTDYNEEVEDVKETLTTPTMKDKFDQDIENNRPESRASQATTVYAPHIKFTSTDNLNTPTQTEHLKNLSPVSATFTEKDSSQRSSTGGSPNTLTMPLNSPETGKVSPMPESPVGIALPLNQDGHKGHAVGGKTPSLSSAAGSFDLSVLRPRIRARAATVGTADVYQDKDNKENDQDSTALKLSFGGNKPSISSIQRDDMSIASMTSGSELNGSAMSMRSNTDDGFGKAGTSTPATVHSWVLDEKSPIKEKPKFELGDETESENEDVDSLPPLPVTQVRARQRQRAFTTSATQSPIKSSFDNELKPTVNFGKYEIVRGGPNDKIMGATLPSLVELLTPHDTTLDVNVLETFMMTFRLFTSPKQLAIELRNRFEKADDIEDKTISDPIRLRIFNLAKLWLEVHWQDREDYSALEAIEYLGITANTMSTFNASADVLLKLTDKRRYEHENMTSANQNAHSYNSISKQTKSKRQAGQNSLKSFINYQFTESNSSIKNRNSRSSMGSTTDQAPIPQISRSLLNHLKSPQGLTSAPLPTDFEPIEMARQLTIMESRLYQCVTVDELLSVNEGGSTKKGVDVHVVRPALKAMSEFTTRVTSWVSESILREDEARRRVPPIKFWIKVCKHSLSLNNYGLLIAIVCGLTTSTIGRLKRTWELVPVKHRNLLNNLNTLAACDRNYAVYRARLRSTQLPALPYVGLFLSDLTFVHVGNKPTRPSMVDSRRQVINFDKYEKLKNIIKEFMKFQEPFRLTEITEFQTYLHRALTHIEASNESAQDLYNRSCALEPKNSNLGMQKVKGNASVESLRHSVDRKELFGWTRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7J7</accession>
    <name>I4Y7J7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960078.1">
        <property type="nucleotide sequence ID" value="XM_006960016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7J7"/>
    <dbReference type="FunCoup" id="I4Y7J7">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="GeneID" id="18474428"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61267"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y7J7"/>
    <dbReference type="OMA" id="RIASNEM"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="589" mass="67746" checksum="4BD888B0F6E38F89" modified="2012-09-05" version="1">MLEKIAPELLEKDTPKGLSSKSQKRKRNQNDEGSTKQTIMREELVKDSSGHKRYFGRSSVRGLLQRISFYTRTSMTELLSEKRPQFWVDEPDQPCNKPSTSYTAVDDTEMLNLVEHYFNYVNVTLPLLHRERFLQDIPRRKHERGFNCVLMIVCAIGSQYLNTGTDPQTLHFMAGLNYYNNSKAMMLDATTSVATLEDIQAFILLQVYLQKGPSLKSSWAIHGMAVVLAQDIGLCFQWRNDKVDRYTLEQTKRAVWVLFILDASTAALFGRPRILAAEDIQIGLPSAEGFDEFTYGAETRVTYLNELIKLYKILGDILSTIYSAKADHYLSVNTVATVNSNLNEWYRRLPDELRDEDKFDIKLEAFPVELREEMKKNENNDEDDDLKYTRWYLKIAYYMTQIYIYKTFIPDTRSEDLHQFRQTSLEICTNASKSIISTQMKMFCGRDNDDRTFFADGLISWGAFTSTLILIINYCECKNNNTENEEDLDFISMAVHLLKVRESRDLMSGRAFDMVSNICMKAGLPIKSTSSPLQTGNLTEYDPQFMNDDLNDALFGVQNLNSFLPLPDSALTDDWSGMLGSMFDANYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y813</accession>
    <name>I4Y813_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ESCRT-II complex, vps25 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_40346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959826.1">
        <property type="nucleotide sequence ID" value="XM_006959764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y813"/>
    <dbReference type="FunCoup" id="I4Y813">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y813"/>
    <dbReference type="GeneID" id="18472166"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40346"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y813"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="167" mass="19251" checksum="A672155667FB8C5A" modified="2012-09-05" version="1">MTTIIDFPPFYTQQPNVETLSQQLQLWSQHILKVCKQRRQFQLSMSDDIWTNEKIQRTRVILLSTVICYYLLISTGLATYTDTTKESVWVYWRTLAEWAAVLYDHVDGTAQLNTPLTYYELTEGDYSHLSELNGLPTPILRSAINILVKQNKAVTIKTSNGEGVKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y814</accession>
    <name>I4Y814_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_40349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959827.1">
        <property type="nucleotide sequence ID" value="XM_006959765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y814"/>
    <dbReference type="FunCoup" id="I4Y814">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y814"/>
    <dbReference type="GeneID" id="18472167"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40349"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025741_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y814"/>
    <dbReference type="OMA" id="FYEKQMK"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="26197" checksum="1854A1F15C9CE875" modified="2012-09-05" version="1">MPKEATKKTIKGARKGVEKKPEGKFEDQDEININEYNSDSSSDSDGSSDDEAISKEAKSVPKAPTNAQVKAKLEKAKAKKNQRGVVYVGRIPHGFYEDQMKAYFSQFGEITRLRLSRNKKTGKSKHYAFIEFENLQVAEIVAETMNNYLIDNRLLVVEVVDEKDINEHLFKGANRKFRAVPTDRIERISFNKEKTEEEKEKSKKRYQDKLAKKQEKLNNAGIDYQIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y857</accession>
    <name>I4Y857_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959870.1">
        <property type="nucleotide sequence ID" value="XM_006959808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y857"/>
    <dbReference type="FunCoup" id="I4Y857">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y857"/>
    <dbReference type="GeneID" id="18471712"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33587"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y857"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="145" mass="15131" checksum="2E98366CC0535AA8" modified="2012-09-05" version="1">MATKAAGNTSLGPQVAEGELVFGVARIFASFNDTFVHITDLSGKETVSRVTGGMKVKADRDESSPYAAMLAAQDVAARCKEVGINALHIKIRATGGTATKAPGPGAQAALRALARAGMRIGRIEDVTPVPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y897</accession>
    <name>I4Y897_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_58249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959677.1">
        <property type="nucleotide sequence ID" value="XM_006959615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y897"/>
    <dbReference type="STRING" id="671144.I4Y897"/>
    <dbReference type="GeneID" id="18473000"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58249"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010069_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y897"/>
    <dbReference type="OMA" id="MCLFNVE"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="223"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="645" mass="72296" checksum="DA755484417AAF75" modified="2012-09-05" version="1">MSYHPIVKEPKLALKGYNSNTTNEQDIANELQGCLPLRICLNYDSEDVEANVEFKMLESAEKAFTLYRNLRFSDKNIELLPYDDNNNLITHIPQSISTPKIFRNLPTTITPDAVYNLTRLYGPIHSIRMINAGVAVVEAWDEDTANNLESEMHCSDVDGQLISVTTYIPPHTNELQPKASAFVPQHQKKHGLVTPLPNSPGSYFGHGPGQQVQYTGTNLVDPCNLFVKNLDHSLESNNLFDHFKSYGHIVSARVMRDENDNSRGFGFVSYQFPESAKTALHAMNGVTIGSKSITVRFHEPKQLRQEKLAAKFAKSGDRLTPSLGLQTPISPVPSDYGGMDNYLTSPPLSTTPLGQRRGSGSYFKAALGAEVIPSLEEFKAMTLPMRNEILAGHMARILSQNGLGEMEVIDKLLINNKLEDLVILLNDNDALIERSQQVQQEMNNLNVGLNALRIDQGGASRAGSMISQSGYISQQSEKERLIMSVQNLGEPDSEKIGEMLNSLGKKERALCLFSNDYLIQKVRDARVLMEAMEGDDDEAKPEMKTEENQNMTAAEVLEKAIKEKTIYDEELYKQTVDYYNSLAHLEVKTQKQKIGENLFKQIKLNGFKSNIAKLTIKILDNEDLKSLILLIKIYPEYLNLIICKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8F1</accession>
    <name>I4Y8F1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959731.1">
        <property type="nucleotide sequence ID" value="XM_006959669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8F1"/>
    <dbReference type="FunCoup" id="I4Y8F1">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8F1"/>
    <dbReference type="GeneID" id="18474320"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61073"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8F1"/>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="123" mass="13498" checksum="4BD4629E2C813592" modified="2012-09-05" version="1">MSSVPIKLVHESLGHVVTIELKSGQMYRGKLQEAEDNLNVSLQDITVTARDGRVSQLDQVYIRGSMIKFLVVPDMLQNAPMFKRVGPNAMKGRGIGTARGRATIMRANARRGRGGPPTVGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I7</accession>
    <name>I4Y8I7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAGE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_29807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959767.1">
        <property type="nucleotide sequence ID" value="XM_006959705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I7"/>
    <dbReference type="STRING" id="671144.I4Y8I7"/>
    <dbReference type="GeneID" id="18471116"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29807"/>
    <dbReference type="eggNOG" id="KOG4562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120844_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8I7"/>
    <dbReference type="OMA" id="KITYSWG"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="1">
        <location>
            <begin position="14"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="27577" checksum="BB6A54886904B1AE" modified="2012-09-05" version="1">MSDSEEDVRMDNYSDNITSSLVRLALSAEGRRTALRKDEITKKCNISGKDELLAAIDGANDILRSTFGYELRELPPKESAKLEDIPPKTGTRAYALINTAEQPNNQSEAFSRHENISHIGILHSILAIIYGNGGIVSDVQLTSNLKKLGISKDQPLPGEGRVLLDNFLSTLSRQNYLEKKKSNVGNHDYEYSWGSRAIVEIGENNISRFILEIINKSRNSNMNSEAAAEIDKKILDDLQRGVGHKYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L8</accession>
    <name>I4Y8L8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959567.1">
        <property type="nucleotide sequence ID" value="XM_006959505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L8"/>
    <dbReference type="SMR" id="I4Y8L8"/>
    <dbReference type="FunCoup" id="I4Y8L8">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L8"/>
    <dbReference type="GeneID" id="18471665"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33376"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L8"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="672"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="717" mass="81877" checksum="3AECA965E5BF7897" modified="2012-09-05" version="1">MGLLSLGTPLDWTDAKAFADFIRTNGVEQFLNIYYSLKDRKGEPLLWGDEVEYMVILLDNSTKTAKLSLRQSEILDNLNNVTDDIVNDSNSSIVSSQVPTFHPEFGRYMIESTPGVPYSAGLKELLTVEVNMRLRRNITKHHLPPNHIPITLTSFPTLGVNYPFLDPHYEPNGEASQSLFLPDELINPHVRFPTLAANIRKRRGAKVAINVPIFFDENTPRPFIDKTIPYDRDLFPGDKEAKEGAAKPDHIYMDAMGFGMGCSCLQLTFQACNVNEAFNVYDALAPVAPIMLALTAAAPIYRGYLSDVDARWNVISAAVDDRTKEERGEEPLKNDKYRIPKSRYDSIDSYLSTSPRNRPEYNDNPLPMNKEVHKALIEAGIELPLANHIAHLFIRDPIVIFNELLKQDNTKSSDHFENIQSTNWQTLRFKPPPPQSKIGWRVEFRSMEVQLTDFENAAFSVFIVLLTRAILSFDLNFYMPISKVDVNMQRSQKRDASRQEKFFFRKNLFPKRDRDIEKYRFDSPRMEPMKKSFDNFKEESNMNGKRTTSSESLASNYNINVEEEIDEMSMDEIINGKDTFPGLMGLVYAYLHSLNVDIETKCQIKKYLQFIKDRASGKYITFATWTRNFMRSHPDYKQDSVITSKMNYDFIIAADEIERGIRTEPSLLPPSYIGSDKLKEPSVMDLSQGVSSGAEPDKRPTPTDGLSRLKGSNLYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Q5</accession>
    <name>I4Y8Q5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_58211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959604.1">
        <property type="nucleotide sequence ID" value="XM_006959542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Q5"/>
    <dbReference type="STRING" id="671144.I4Y8Q5"/>
    <dbReference type="GeneID" id="18472995"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58211"/>
    <dbReference type="HOGENOM" id="CLU_1240978_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Q5"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="24056" checksum="0D6E07F0D097D0CB" modified="2012-09-05" version="1">MMISGNMNSKKPSNTTPNDCHLSSAVLMGGPKNAQSSEFADAICSIDGLVSYAYSSSSGWDAGPKRPSNASQLNTAAEDVGNLLCSIPSPPNTPEESLSPLSTINSGNFNPSPNFLESKKYDDNLSIEFSNGDQWCGFLPSSETLAIEKVEWDSVQFLREDIVALLELGETLNVNNLVVVMPKFIQGLTELIHSFMYVGGALVDLKSTGWGIKDDYIAFSMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T7</accession>
    <name>I4Y8T7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Co-chaperone Hsc20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_11721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959552.1">
        <property type="nucleotide sequence ID" value="XM_006959490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T7"/>
    <dbReference type="FunCoup" id="I4Y8T7">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T7"/>
    <dbReference type="GeneID" id="18470594"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_11721"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8T7"/>
    <dbReference type="OMA" id="YFAMQIK"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="3">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="147" mass="16634" checksum="D3EC19AAF219658A" modified="2012-09-05" version="1" fragment="single">YDINTLQLKKHFLNKQKLYHPDAQTGKSDEEAAHALQTSSLVNKAYETLLHPLSRAVYILELNGIEIGEADSVEDPDLLMEILDLREQLEEATSEDQVQSLRETNKEAINSTINDVSAAFQNENYEDAKNLTIKLRYLTNLDTAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T8</accession>
    <name>I4Y8T8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959636.1">
        <property type="nucleotide sequence ID" value="XM_006959574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T8"/>
    <dbReference type="FunCoup" id="I4Y8T8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T8"/>
    <dbReference type="GeneID" id="18474294"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61028"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778912_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8T8"/>
    <dbReference type="OMA" id="EDNMATK"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="356" mass="40687" checksum="28F4FE666F35BCD8" modified="2012-09-05" version="1">MSEDEQQQYNKIEDDKQTRKRDRETSVEPKADIKSQDSATKRGRTANDEKVNQIRDKVEDISWHNKETDKKSDNEEPPKVVETTAPKKQSSFAAFASTASPFASAPSNASNSLSNKPTVSSSNAFSAFAGSTPKPQVESSDISSFNDKLASTQGESINSDNKLDLKPAQITTGEENEENLLQIRSKLYLLQDEPGTSNGNWKERGVGLFKLNKDKSGRSRLVMRADGVLRVILNAALFAKMPVEHPQEKFVRFSAHNESNKLEHYTVKLVMESSQRRLMRLFWRTCLLPKRKPVRRVKRAMRRKTVMRRIKKILRTPRKKVKITLKKMQVLKIKRTMIITKITKMPMRRSNINIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U5</accession>
    <name>I4Y8U5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959643.1">
        <property type="nucleotide sequence ID" value="XM_006959581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U5"/>
    <dbReference type="FunCoup" id="I4Y8U5">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8U5"/>
    <dbReference type="GeneID" id="18474297"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61031"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="I4Y8U5"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="20699" checksum="AFAA70267ECFD250" modified="2012-09-05" version="1">MGSNLSKALSSLWKTKELRLLMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLVFVIDSQDRDRIDEARQELHRILGDREMRDCLLLVFANKQDLPGAMSPAEVTEKLGLHKMRERSWYVHPSCATTGEGLFEGLSWLSTNVKKRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8V5</accession>
    <name>I4Y8V5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_61034</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959653.1">
        <property type="nucleotide sequence ID" value="XM_006959591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8V5"/>
    <dbReference type="GeneID" id="18474298"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61034"/>
    <dbReference type="HOGENOM" id="CLU_1972169_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8V5"/>
    <dbReference type="OMA" id="MGSWQGV"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM20397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="127" mass="13529" checksum="F22491400F90E1D9" modified="2012-09-05" version="1">MQKRSSIHPSVSRPSVAGPPISSILPAKALELHGLEQVKGATSQLLERVEGLAEEAHTLAEGGEAVGKVLGVWEELFSVIRLMGSITNQQSEQNPENGADDTAEQDSDSPTEKLVRIPVDGHSIVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X4</accession>
    <name>I4Y8X4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959442.1">
        <property type="nucleotide sequence ID" value="XM_006959380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X4"/>
    <dbReference type="STRING" id="671144.I4Y8X4"/>
    <dbReference type="GeneID" id="18474238"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60905"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015435_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8X4"/>
    <dbReference type="OMA" id="LIRHYCD"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="755" mass="84562" checksum="EDBD15DF66AC5555" modified="2012-09-05" version="1">MSSDANSHPVQNMINLMGSTHPAVQDSLPRLSEIITQNDRLPSESANTASNKSQRPKFKRSRDGCLTCRKRKVKCDMMTPVCLKCTSLGRECTYPNPNETQNNKRRKVSSPSTSARSVEPPETSSHTERTKQNYQTTYIDPFADPELSLKRLQALLGSKLLAQLIQSAPDVKVESEELALPAIYDSSSQHHLPSVQPITQNTLPVPSTSSAMSVLPSGSSALPPTSFFDPATSRMLPPQLDPAMMNTSTMSTVSVPFSSFNSNLVGTNSPPAFASEYANYVSPPPFFPSPPILNGNTENEYVYNRPSPATSTSSPSSLPPLINDSFQHSNSIINANPQSRQLLHNFLSESKKLLCAINEPKNPFLALSIPLVLNSNQAAITYGILAISATHMHFIRQKQGLEASQELNLSKHLKSMALKQVMMPLLNDAHNNQDVDMSLLAFIAVLKYDVLSASVDWRQSMNVALALVRNLGGPAAMLGLDRNLRLMHNVSKKSLFIRKTFLEELTAHEVFACLTTGETPQLLGDDNQSWWFDMETDEKLNSEHYESFERSYGMSRYMLDIIARSCKLYNQRRNLKIPIPIDESEAESLKGILPVELLNAMQDLRSRTFAMYGELENMTKQSVVIRHQRVECGDLIYRHTLMIFLSREIFNISMQDSSIQSAARAVLGLCSEATREMGMAVMLIWAIIISGVQMYKPEDRDWVQQLFSSCREWYCSDLECAEKIVKECWQRQDKGIANKDWRSVARDLQIDVMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y985</accession>
    <name>I4Y985_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959324.1">
        <property type="nucleotide sequence ID" value="XM_006959262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y985"/>
    <dbReference type="FunCoup" id="I4Y985">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y985"/>
    <dbReference type="GeneID" id="18474204"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60847"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y985"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="548" mass="62758" checksum="816D65A3B4C06313" modified="2012-09-05" version="1">MNSIITDCDESYNYWESMHYLTHHNGFQTWEYSPVYSIRSWFYIIINSPIAFMLSYFGADKRIAFFGTRSYLGLLSSVIEASFYSSVCQTFNPRVGRYLLAFLIGSAGMYISAIALLPSSFTLYTTTLGYAFAIKPSTVSKDGFKRCLFATLSFAFGAIAGWPFALTLAGPFVIEQLFMYTGGQSIFKKRLEQFIKAVVVASLLFIPVVAIDSLYYGKLTVVPLNIIEYNIFSENGPTLYGVEPPHFYVLNLLLNFNFVFLLAVASLPLAALFERKYLTFVTIRLLPFYGWFALLSLQPHKEERFMFPSYALLCLNAAVGLYYLRTLISTSYSHLVKRLTKSSKVVISSNIIARTLTVSIVIISIVLSVMRILAMQQYYHAPIDILFEFSEKELSTRTHLNERQITLCYGKDWYRFPSSYLIPQNVDVQFIESEFDGILPSHWPQNSEGLLNNIRRIPPNMNDQNKQERDRFVPVDSCDYIVDVVLPSTTFSELEPDFANSNDWTIATSLPILDASLSHIATRTLYLPFNFWQKRNTFGEIRLLRRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9T5</accession>
    <name>I4Y9T5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_20170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959180.1">
        <property type="nucleotide sequence ID" value="XM_006959118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9T5"/>
    <dbReference type="STRING" id="671144.I4Y9T5"/>
    <dbReference type="GeneID" id="18470826"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20170"/>
    <dbReference type="eggNOG" id="ENOG502S3W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1760239_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9T5"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="16389" checksum="E7E1610E2CBC1834" modified="2012-09-05" version="1">MDHQHEENNKLLKVIASDIILHNTSQHRSTVGSIEKTNATAMKGNIDAAVDDFKKQLLPEVRGLVKEIGDLREQKRGLQHEISELFAIKSKQGNGAPPPPKVDYNPRAPPAKENKKDEPPKDAAPPPPAWLSWQPPVNFGPPPLPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Z1</accession>
    <name>I4Y9Z1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_39523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959308.1">
        <property type="nucleotide sequence ID" value="XM_006959246.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Z1"/>
    <dbReference type="GeneID" id="18472120"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39523"/>
    <dbReference type="eggNOG" id="ENOG502S3W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241493_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Z1"/>
    <dbReference type="OMA" id="PTKMQAV"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="290"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1669"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1681" mass="183768" checksum="53CF27E0F1EA2392" modified="2012-09-05" version="1" fragment="single">MSDIDRDGQDIRPEEAAVLEQLEIMSNQSSSQPYVPHVLSVIGEETEPGTSSQSNSNSRSRSSSTNDVFKSFPDFKSLDEADTTSSHSSKGHPASTKPPSSLQHVPTISSMSSRSSAQASSIPTIPSQYSSRQPPALETPAFSNSPFPNMAFDQQSTHSRSNSASENTSRAGNLIAFFENSKEKEKEQEKERDTYSSPVISKVIQTKRPINLNRNKDEQMPQKPVQQPNIPSLPSPTRLESLTDGWETMISSTNTTDLSTPLTSHKTPMTSQRPSSPIDLSSFDDITEQIARAGTLWYLHVHDGTPYRWVRARAALLPTTLKLSFLPSPDLPNSRLQRQIVTLDLNHCSEVRSIASPSNPASHKMDLGLVAAREQGGLEGVLNPFVLVYQDGWERLATDSARERVQWVGAFWDVIRPIQTPQTRMLQREPSNASGSSATSRNSPLLQPGQTTLTGTPIVRRPVSPSNSNAGSVSAFNVRSEDFGAPEPTASDSEQHSNSMRSRSTKSKKRESLDDMSIGMIATASTSDTVRGLGILSDTRDGSANDSEADDIIFPPSVSVRAHRRGGRRRRSGRSSDSSSTSSTTTTKSTSKKSESKSYGTSTERMLKSPKLGQLAEDADEEDEGQTRSAVSSLEKDNESTPSPQQPEIATTPKTQSARSHSQSRSRTHSMRSIQKTPEMSAQTQNTNDVMRSIPSSSSSSRSLREIDENGTSTNELMRSLSRRSSKPSTMKKAESLSSSRKSLAQIADELGDSPEDQELKDALSDLINKSKQGTPEQGGTPSASSVSLSRRSGMKRNGSNASSNRSSMLRSKDKSMSTEFLTAQTHPQSQSNQVTSTASQAPLTTHNSTAPTSTASQAPITTRHSTVPSTHTNSSPSAPLPTNNTEVSERKPSSLSSSIKSSTKTPTRSRSQKSASSKARSDIAPPEQGSEEIVEIGTEYDDEFDMDLLAPSRTGSPDSMWPPSRVSSLVSRSKAPTTVSRSSTIDSRLLAPTVISASSDGSTMMQLEKSSDGQTVTPEIVSDIDRKFLTGELEKLFNSLLARDAGKSTQNDNILNAIQDELRLLAEAIRVLPFRRRGSGDLSVTTEGQLTDHQTIPDLPAAPQAETFSDNKSGDILREIRHKSSSNSMPPPAQPIVQDDKAVHDLENKVNSLIDVCRDALDSTGRDRRVRDDTEERNNKHMMRLENLMRSLIRHFTHGGASSISSWPDMMSEHPFDDVEEDEIDDAASSSTVTQKPAIEQVRPSPDDMYPHDSISMRDVMGPLPTPPILDSNEISEPEIPHISRRERDFTSRRRWARSLSPPPKSLSSVSTDTAEDEYDDMLYPDIYEPGPPLEEGYVEELPREEETPPAKETKPTPKIAMDEGGYPRTAKEWNNHEFRPPQERLAKPHGPQFPPGGMSMRPPMPAPHMNMPHPMRPNYTSFRGGFRPPPNFNGNVRPAMQGLRGFHPPMLPPMMGGAPMRPMMRPAMGTGPIHGAGPMPMNGSVPMRSTPMFRPSPPMMNSARGGQFGRFGPMPPPGIPMGGMGIPLRFGSEFHPGFNETLYNTRRAGWNTEEILRHQMDADRYLGALNNWLEKEVSAKINEWGPIQRQIKDMELVLRDVRDSVASGARSMPDGSNRGMADPSGQNRGEVPSGGDKDSRAMGDAPQGKDGSDRAVMSELGSISPHYGDEKAVHPSETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Z8</accession>
    <name>I4Y9Z8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coregulator that functions together with transcription factor HSF1. Positively regulates the expression of laccase LAC1 during glucose starvation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959055.1">
        <property type="nucleotide sequence ID" value="XM_006958993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Z8"/>
    <dbReference type="FunCoup" id="I4Y9Z8">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Z8"/>
    <dbReference type="GeneID" id="18471606"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33018"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Z8"/>
    <dbReference type="OMA" id="SYAYNIK"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="643" mass="70293" checksum="969AF8AEA9606C99" modified="2012-09-05" version="1">MSTSSKAIGIDLGTTYSCVAVWQNDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQTAMNPYNTVFDAKRLIGRKFSDDDVQSDAKHWPFKLIQDSADKPKIEVEYKGEKKQFTPEEVSAMVLVKMKDIAEAYLGTTVKDAVVTVPAYFNDSQRQATKDAGLIAGLNVMRIINEPTAAAIAYGLDKKTEGERNVLIFDLGGGTFDVSLLTIEEGIFEVKSTAGDTHLGGEDFDNRLVNHFVQEFKRKNKKDISGNARAMRRLRTTCERAKRTLSSAAQTTIEIDSLFEGMDLYSSITRARFEELCQDLFRNTMDPVESVLRDAKADKSSVHDIVLVGGSTRIPKIQKLVADFFNGKEANRSINPDEAVAFGAAVQASILSGDTSEKTQDLLLLDVAPLSTGIETAGGVMTALIKRNTTVPTKKSEVFSTYADNQPGVLIQVFEGERARTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVNAADKTTGKSNKITITNDKGRLSKEDIERMVSDAEKYKAEDEEAASRIQARNGLESYAYNLRNAMNDDNLKDKFSEDDKKKLDEAVNETISFLDNSEAASKDEFESRQKELEATASPIMQRLYGGAEGGMPGAAPGGEQPSAGNDGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA60</accession>
    <name>I4YA60_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_19804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959044.1">
        <property type="nucleotide sequence ID" value="XM_006958982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA60"/>
    <dbReference type="FunCoup" id="I4YA60">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA60"/>
    <dbReference type="GeneID" id="18470812"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19804"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="I4YA60"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19313" checksum="CC8AC3C038B5565A" modified="2012-09-05" version="1">MTSNTHLARQLQQLKKHPVDGFSAGLVDESNLFEWEIIIIGPVDSLYEGAILKAKLSFPEEYPLLPPKMTFLTDLWHPSIYNSPDRKGELCISILHPPGDDEWGWEDASERWLPVHSVESILVSVISLLSSDSPCTDSPANVDAAKQVREDPAGYKKTVRRLARKSAEDCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA87</accession>
    <name>I4YA87_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_33078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959139.1">
        <property type="nucleotide sequence ID" value="XM_006959077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA87"/>
    <dbReference type="STRING" id="671144.I4YA87"/>
    <dbReference type="GeneID" id="18471618"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33078"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_2_1"/>
    <dbReference type="InParanoid" id="I4YA87"/>
    <dbReference type="OMA" id="CLSRDFF"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697535" evidence="3">
        <location>
            <begin position="17"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="383" mass="43373" checksum="133BB6218EBD81D5" modified="2012-09-05" version="1">MKLSLLALAAAGFAAALPTTLNEGYSEECPNGLAIRPEWSQMSKKHRKEYISALQCMINKPSTVNETQINSHYEDFWYTHQFPGPAIHFVAAFLPWHRHYVYTYHQSLKECGYTGEMPFWAWDWNADDVFKSSIFDPDSESGLGTNGTTPEGAPINGFAVTDGGLANHQIEYPYKHSFQRNFNLNPPGTPVSLDTFIKESEVTKALAYDRYDYFHKYVEGAPPQEIAKGVPEIEGMKGFAGMHGAVHRLIGGDMASIIDHKAPDWCPSFESDESSNYGANASPNDPLFFVHHSNIDRIWAKWQDQDPENNKFAYGGFTFHNYTTEEGTGVASINDTLEFGFITDPVPVHYTMDYQKTYCYKYADKDYREEDNLVDFLAQGFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR0</accession>
    <name>I4YAR0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959038.1">
        <property type="nucleotide sequence ID" value="XM_006958976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR0"/>
    <dbReference type="GeneID" id="18474104"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60694"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="InParanoid" id="I4YAR0"/>
    <dbReference type="OMA" id="DAAVSIW"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="236" mass="25583" checksum="EF23074BBF3EDF64" modified="2012-09-05" version="1">MQASSTIAKPFEFKGLYNGVGSVILSTLPASALFFLAYENAKSELSKYVNAPTAQLTASILGELLACSAIAPADTIKQRAQIQGNQLSSFQVAKIVFSQKSAWSDIKSGYKAVVLRNLPVTAAYFPLYEWLREKVEKDFEISKPNAALFAGGFAAMPLAVITTPLDVVKTRIMLGQGIDSNRKGVFSVGLHISKTEGIRTLFKSGMLRGLGAAVGAGIELGCYEYTRKYFKLYTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS4</accession>
    <name>I4YAS4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_60560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958751.1">
        <property type="nucleotide sequence ID" value="XM_006958689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS4"/>
    <dbReference type="FunCoup" id="I4YAS4">
        <property type="interactions" value="634"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS4"/>
    <dbReference type="GeneID" id="18474029"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60560"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="I4YAS4"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000711">
        <property type="entry name" value="Probable cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="37125" checksum="49E4EDBC9684CE6E" modified="2012-09-05" version="1">MDNYTRLEKVGEGTYGVVYKAKDVNNGRIVALKKIRLEAEDEGVPSTAIREISLLKELRDDNIVRLFDIIHSDAKLYLVFEFLDLDLKKYMDNVGQKKEGLGPDIVKKFTYQLIKGTYFCHAHRILHRDLKPQNLLIDKEGNLKLADFGLARAFGIPLRTYTHEVVTLWYRAPEVLLGSRHYSTAIDMWSVGCIFAEMVMRQPLFPGDSEIDEIFKIFRILGTPNEDIWPGVKSLPDYKTTFPQWSRVDLYKAVPGLEPEGIDLLSQLLIYDPAHRLSAKRALNHPYFETAIETDIPSITASIAASAQQRAAQKARTASQASLAAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT3</accession>
    <name>I4YAT3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_38776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958759.1">
        <property type="nucleotide sequence ID" value="XM_006958697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT3"/>
    <dbReference type="FunCoup" id="I4YAT3">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAT3"/>
    <dbReference type="GeneID" id="18472080"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38776"/>
    <dbReference type="eggNOG" id="KOG0325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_2_1"/>
    <dbReference type="InParanoid" id="I4YAT3"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="232" mass="25916" checksum="D37DA3ED9DCBF19A" modified="2012-09-05" version="1">MSIYYKRLPGFINYKAGLELQERLVAAKPTKDVLLLLEHAPVYTVGRRTTDENIEESTRLRALGAHYELTKRGGQITYHGPGQLVGYPIFNLSRLNLSVKCYVDRVEKSLIRMLADQYRIRGQTSEHTGVWLDDVHKIASIGIQVRHRITSHGFAINITNEPLDWFRNIVACGIHGAKMTSVASALNNNSISMDDATLAAANAFGKVLDKEVQQLDDPEIDAIISDVLDNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAX1</accession>
    <name>I4YAX1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_54711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958790.1">
        <property type="nucleotide sequence ID" value="XM_006958728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAX1"/>
    <dbReference type="FunCoup" id="I4YAX1">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAX1"/>
    <dbReference type="GeneID" id="18472686"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54711"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_1"/>
    <dbReference type="InParanoid" id="I4YAX1"/>
    <dbReference type="OMA" id="KTYMGPL"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="504" mass="54183" checksum="0A8F7F287C2D856C" modified="2012-09-05" version="1">MSSSKIVSKLSALKQTIDIPVGLFIDGEFRKGTGSSFYSINPETEKPVISEAIQGASRNDVDDAVKAARAAFETTWGQNVSGPERSALMRRLADLIDRDTEKLAIVEAIDGGKTINWCEGDIADAAACLRYYAGWADKISGQTLEVSTANKMSMTLHEPIGVVGQIVPFNYPIMMAGWAMAPALAVGCSIVFKPAEATPLTTLLLAQLVKEAGFPNGVFNVVNGLGRETGAALSEHHGIDKISFTGSTATGRSITVAAAQSNLKKVTLELGGKSPSLVFDSADIDEAVKWSAFGVFENAGQSCSAGTRLLVHENVYDDFVKKLAQAADEIKLGHVLDRSTQQGPQIHKAQFEKVLSYIEAGKKEGARLVTGGKRLGDKGYFIRPTVFADVNNKMKIAQEEIFGPVVVVIPFKTEDEAVKMANDTSYGLAAAIYSKNADQVGRLMHKLKAGTVWVNQYTMLSHNTPFGGYKQSGWGRQLGSYGLEAYMNVKGVSWNYGPEPAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB75</accession>
    <name>I4YB75_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_46697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958889.1">
        <property type="nucleotide sequence ID" value="XM_006958827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB75"/>
    <dbReference type="FunCoup" id="I4YB75">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB75"/>
    <dbReference type="GeneID" id="18472396"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46697"/>
    <dbReference type="eggNOG" id="KOG0871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="InParanoid" id="I4YB75"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="156" mass="17301" checksum="D2E3A3B9FFC1AD17" modified="2012-09-05" version="1">MSDDEKNIPTASSFDDDLTLPKATAEKLIKEMLPPELTVAKETRDLLIECCVEFIHLVSSEANEACEQDSKKTISPEHVVSALKTLGFETYLKDMEEVLRDHKAQAKVKSAWDKERKGSRLAASGMTEEQLLAQQEELFAASKARMEASTTGPQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBB6</accession>
    <name>I4YBB6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_69129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958612.1">
        <property type="nucleotide sequence ID" value="XM_006958550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBB6"/>
    <dbReference type="GeneID" id="18475531"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69129"/>
    <dbReference type="eggNOG" id="ENOG502SEU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486804_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBB6"/>
    <dbReference type="OMA" id="ETISCGY"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="420"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="560" mass="64674" checksum="65A74DA8ECC9F6FC" modified="2012-09-05" version="1">MHRQKEQYENKKKEAEERDKPQRNRFNWMLDDIGDDSRKNSSDLNERDIEEPFEYRLSDTGSASPPSMDDAIYNIPSTSKDKDIHRIPSKESGKASSKKDKPQLQMRLGSPMSKYCRNKEKEQHNAKEKAKQKEIAELRERYRENENSKRSAKDKDKETNNNYHTRIHISNSANFDDDDVESREISQQRHQTKQRIESDTDSDGVQVTNPISRKKKSPRQDHKQPERADILGSYIKAQAKGQYDERPPEKAHNSANTEKVTDNIADTIEKPYKGTSIDISDEDSSRKLIDKPKGKPRARPRAIVREPAADQSSLKSYFKPTIKAPTNNLCPVCDQVLPQFKSQHFKAVLKEFLNVAKVSPRSSNAFGMRAHVLAETELCTAHELDTKIIPEGRKKGYPFEHDWNELSDRILKLSKSIRTIVKTKENSKFWQKAKEEYLKRGSKRAKGLDAQFEHFEDEQPGYYGEIGLMVILFNLNLMVSNKSKKKIKITDESVHPLTSNDFMRRILVPEVANLLISQDRAISIEKAEEIRKDSREYGNALFSSDNKDINWRPPILEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBG9</accession>
    <name>I4YBG9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_57633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958663.1">
        <property type="nucleotide sequence ID" value="XM_006958601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBG9"/>
    <dbReference type="STRING" id="671144.I4YBG9"/>
    <dbReference type="GeneID" id="18472938"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57633"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="InParanoid" id="I4YBG9"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123176" checksum="DF7DBAFE4290B72D" modified="2012-09-05" version="1">MSLAAGNNFDDLTTGDLYAVYAQRPQNSAYTGLPVIGGQNYNELPTLRSLLPEEISSNGDSVQDRDFDYNEDNKDDSSAGYQDDQDESYEAEYEQVEDNTLYSHQVEEPVAVPLNEEFLDKTGDEEPLYVNAKQYHRILKRRQTRQRLEELNRISKERKPYLHESRHRHAKRRPRGAGGRFLTATERYQRYERYGSYDRDTPSEISHVDTEVDNIVIEKITVTFNLNKDKLAAAYFDTLTLLHQLQPNEIYCSLTVPDGFIKVIKLFIANVKPDALLQLAPWKEFSYESSKSRILQLSIGSDSHLDSTSQPSWVDPLGQMESDTMDSRLKEMYLSGFINFNYRLSIGAIGCLILVLQRHIAQDSATTITSASCRVEDLDLSGLETWQIDKVMQIDNDALMALSVFSSEQHASIHSNNSKEGLSLFNLLSETKTHVGTQLLQRRLRQPSCDISNINDRLDAIAILIHPQNVSAVNDMRMSLSKVGKGVNVMHVLNSMKSGKTSIRSFKCLVNLVILTEELYEGIAALAALESKQLITDVGTINPILKAFDINICHTVKNVITSTIDFNDSKAEHRLIITTGLDDELDNLRQQFNELDSFLVQVAQEIHEETPSNIANEINVVYFPQIGYLIALDIVNNGYENIEDRDMIGAEIAWEYQFMTEMTLYFKSDRMRELDYHLGDMATLIADRETEIIYELTQHVLGYSNELSIMAENISELDVLLAMTRVSEVHGFSKPLMTDNPMIRISNGRHPLQELCVRTFVQNDTHLKKSLEMRVKIDDDIDIIESRKITPFSAVVPMTPNKQRSGTLSNVVQNKMQDIAHSTMIITGANGSGKSVYLKQVGLIVILAQIGCYVPAESATIGIIDKLFSYGSVHTCNVQRIIIKSKHLEAMQSAFMIDLAQVTHAMRNATGRSLVLWDEFGKGTLPSDGAGIFAASINYLMRRGENCPFIIATTHFNDLWENSYIKLAASVVITHMRVKISKNDEGNTTLTHLHKLELELSEDSGAFDCALSNNIPIDIVDKARHISQLYLSNTLDEVATDTLDEDPTDELLVAQDITRRFLEWDIEEAYAHNNNSSAIREYLVDEILSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBH6</accession>
    <name>I4YBH6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958670.1">
        <property type="nucleotide sequence ID" value="XM_006958608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBH6"/>
    <dbReference type="GeneID" id="18475539"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69173"/>
    <dbReference type="eggNOG" id="ENOG502SD4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561640_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBH6"/>
    <dbReference type="OMA" id="IMPGHPY"/>
    <dbReference type="OrthoDB" id="3262547at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="486" mass="54391" checksum="02CC256B5CECC0AA" modified="2012-09-05" version="1">MLIQLKLNCLNHSNWILLSNLRTIEAPTPLRVRPQTGKEYDIEVLLNAASKLIDEYRPLPRTKQHIRNLRKQFQEVEERMQNYQNIIDSPLDSKMEDLPERQQLQNDSASPQELIRVQTEEVKKMQAKVIALKKRKEVLSATVKAQKLEAQVKSTSRQAPPTPIQLPLRQMKEIQKRANTPRKPKLATDQREAEIMKGLPQDDEDDSFKLGNENTLNQSTLLGNTSDEMNLMPSTPTLPSGGGSDMFMNMDTPQPQSHAPPKQPQFEFEDEPESIDLTMRKPTPPSSPEFDPPPKFKDIEKAASTTPMATPKEKTPIPEAPSAIPERDTTPMIETTPEIEAAIKLIWNGFGDVVKPKDATSESMDTPHVDRMVQLLRDAIEIVPAASQQNEPGSPTHSILSIASSLTNAKELNNPQTATSAALLLKLLTTSENRLSMQEAKDHLGLLIQSKGWPSELPTKSIYALVGKRLIKLDRKGASATLRFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ3</accession>
    <name>I4YBQ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3">2.1.1.233</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase methyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958429.1">
        <property type="nucleotide sequence ID" value="XM_006958367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBQ3"/>
    <dbReference type="FunCoup" id="I4YBQ3">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBQ3"/>
    <dbReference type="GeneID" id="18471526"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32598"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031312_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBQ3"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="28018" checksum="E8A0DFD253DE7D93" modified="2012-09-05" version="1" fragment="single">MTTNTTDDATRLTDLDAAISRLSAVKKGYLDDPYAELLIGRLARAQDQNRPPIINIGTHVRVYSIDKLINKYLSGFDNVQIISLGAGSDTRFWRFNNDERINNYIEIDFDEVTSKKAMLINRNKELKSILGNDIKIEKGGSRLISSKYKLIPGDLRKVDINDLLEPYKNKDDPTIIISECVFVYMSIDSTNKILESFSREFKESLVIIYEMTNLDDKFGKVMISNLKVCKYSIILSPKYVLVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ7</accession>
    <name>I4YBQ7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958432.1">
        <property type="nucleotide sequence ID" value="XM_006958370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBQ7"/>
    <dbReference type="FunCoup" id="I4YBQ7">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBQ7"/>
    <dbReference type="GeneID" id="18473929"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60407"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="InParanoid" id="I4YBQ7"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697797" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="216" mass="25019" checksum="6FFBA06AC2EF0CF3" modified="2012-09-05" version="1">MKQFNVLLILLILIEFTQCLHFYMESNDRRCFLEEVPADTLVSGKYKAEEYDQDKREWVTANSLGVLIQVEETEEKHPVVNSKGPSIGSFTFTSHLAGDHTVCLSTNSSNVSWYKGKPTLRIHLDIAIGAVKHDESADLNHLQTLTNRVRDLNAKLNDVRKEQEFQREREVEFRDISDSTNKRTITWSIIQMIVVAAACYWQSSHLRNFFNEKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBT8</accession>
    <name>I4YBT8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein ES2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_69007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958460.1">
        <property type="nucleotide sequence ID" value="XM_006958398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBT8"/>
    <dbReference type="FunCoup" id="I4YBT8">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBT8"/>
    <dbReference type="GeneID" id="18475507"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69007"/>
    <dbReference type="eggNOG" id="KOG2627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024820_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBT8"/>
    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52074" checksum="E0E11F8B4B51C670" modified="2012-09-05" version="1">MRDHRDDPRYTPTPTSSTTAKQNNALVIPKTLKTSLNSQIVLSEEAYTKALSDIIKRDFFPDLKKADDLSYDINNWVGNKAADEETDSQHIEYDYSRMSLEQFQSKFTSEDNASFSYLLHKANLKRRERYAWAYNAELLANQRRIESGDRLSRQIEDVSSILADGEKRLLESNIGVNDISDFGGEGNEQALVRREKAINQQVQLGLEKAPKEGMSLVPSSSKDVRKAGVDTWGFTATNNLMFNPDTNTPNYLALVDKEAENRQNRVTNYAATRMSNDDDDNMSSSMASTAQINAAVNATSSTSSDAGSSTPHIGGYKFVESMPSPRAHQLPSSSINSMMVSGTLSGTPRRLDEEDEYDNCRYYAYKTIQVLKLPSAGDFKIPKISRRDRLGHQLASHVKTKQTPAQSTPTSRTPRGVSLSPAGHALLEKTKRRRTNAEATPSSFRSVRQSPDIRRKDKGWTPTPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBU8</accession>
    <name>I4YBU8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_28794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958470.1">
        <property type="nucleotide sequence ID" value="XM_006958408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBU8"/>
    <dbReference type="GeneID" id="18471060"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28794"/>
    <dbReference type="HOGENOM" id="CLU_1166634_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBU8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="238" mass="26624" checksum="1AD77438BAF096DE" modified="2012-09-05" version="1">MTDTRDTKRVQNLVRKYYCGPLARLSLVGLIACQYATLRTLILNAFRFILPYKADISFNSMSFNRNTVMADAGSYIAGIQYGSFAIAEVKHVFCRLRYKKHYADQIVADSDKLILGRFTFRAFFLNHQDDIAINLTIYDLLSAGIVAGLIFSLDIAYLQELSESSTDPVQNDLESKAGLNAIEKIVEKPLNVQTPLNIAKSKPQVEARVNTLVSQPISSANSIRKISGCMTFSLEYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBW8</accession>
    <name>I4YBW8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958490.1">
        <property type="nucleotide sequence ID" value="XM_006958428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBW8"/>
    <dbReference type="FunCoup" id="I4YBW8">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBW8"/>
    <dbReference type="GeneID" id="18473948"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60442"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBW8"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="921" mass="102634" checksum="C685335125A15725" modified="2012-09-05" version="1">MSNWQPQPEGLEQLLSLLRDSLSSNNQVQQAVTQRLETFNAIPDYNNYLCHVLIKATDQEERVRSVAGLILKNNIKFGWKQWPADSQEYVKSILVDGITDQAPMVRSTSGTAIVSVLSECGPENWPLALSRLMASIDSTNVQEQEGAFGTLAKICEDMYKNLDCEIAGVRPLDFMIPKFIQMLNHQSPKIRIHALSCLNSFIPTQSASFIANIDQFIAALFQIASDGVSEVRQFVCSALVRLLASRPDKLVPEMNNVATFMLYSTQDKDDDVALEACEFWLTFAEETHLAEHLKPLLDKVAPVLLNTMVYSENDLVMLEADDDDEAVPDKDTEIKPHIYGGKTHTQSSEAENSHQKFSREAEASSDEEDDEDDYDEFEDEELASGWNLRKCSAAAMDVLSINFGVDLLNILLPYLKERLFSQDWLQRESAILALGAISEGCIEGIQPHLPQLVPYLVNALNDPKPLVRSISCWSLGRYSSWSVQPLSVEHRNNYFVPTMEGLLRMVHDKNKRVQEAGCSAFATLEEEAGKELEPFLKPIIEHLVYAFQKYQRKNLLILYDAIGTLADAVNNSLDNEEYVTLLMQPLIDKWQNLADDDEDIIPLFECLSSLTVAAGSSFIKFAQPVYERCSRIVHGNLLAFQSAVERNDEDNIPDRTFIIVALDLISGMIQGLGVNSQELITSNQSTPPLLNLLLFCLKHPDNAVKQSAYALVGDLAVSCFPVLLPALDSFLPDLIQQIEITPTTDAISVCNNAAWAAGEIATSFTNYPDLNKDNFVKFVPSLIERLVPILLHPKSVKSLTENAAVTIGRIALVCPEIVAPHLQIFAAQWCQSLWEIKDNEEKDSAFRGFCKLVQLNPSGLASSFQFFCNAVVRWTSPSAILNEQFNALLHSFKAAAGASWDAQMAALPAPISTRLRDRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBY4</accession>
    <name>I4YBY4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4E class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_57534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958505.1">
        <property type="nucleotide sequence ID" value="XM_006958443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBY4"/>
    <dbReference type="FunCoup" id="I4YBY4">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBY4"/>
    <dbReference type="GeneID" id="18472925"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57534"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBY4"/>
    <dbReference type="OMA" id="MSARANF"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="31222" checksum="85196ABB98A3B63E" modified="2012-09-05" version="1">MTTNDEKTTVPETAISASVQAINDSVDNLKLSDKPELEDGEIKEDDISPEDMKTVFDDATGFNVKHPLFNAWTLWFDNPKKSAGAQNWLDDTKEVITFDSVEEFWGLYNNILPPTHLPQKANYYLFKRGIRPAWEDEANADGGKWSVQFPREKWRDRIDRLWLDTMLSAIGETLEGDLSENPSDDLITGVIISTRPNFYRLAIWTRQTTSVNTELTEEEKDLFERMEKLGKTWKHDVLGFGEGEKLGGGLATEVEFVGHKEGERKHRARGKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC34</accession>
    <name>I4YC34_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_64474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958552.1">
        <property type="nucleotide sequence ID" value="XM_006958490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC34"/>
    <dbReference type="STRING" id="671144.I4YC34"/>
    <dbReference type="GeneID" id="18474930"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64474"/>
    <dbReference type="eggNOG" id="KOG1372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_1"/>
    <dbReference type="InParanoid" id="I4YC34"/>
    <dbReference type="OMA" id="HWQTVNY"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="371" mass="42462" checksum="575516782F7C08D8" modified="2012-09-05" version="1">MESLIMKDKTNLEIKVEEYRKRKVALISGITGQDGSYLTELLLSKGYQVHGIIRRSSSFNTGRIEHLYKDIHDMPDMILHYGDLMDTTNLVSIISKVQPTEIYNLAAQSHVKVSFDMAEYTGNVDGLGTLRMLEAIRITGLDQCIRFYQASTSELYGKVVETPQSETTPFYPRSPYGVAKLYAYWIVVNFRESYNMFAVNGILFNHESPRRGRTFVTRKITRAVAEIKLGKQECLYLGNLDAKRDWGHARDYVDGMWRILQHDIPEDFVLATNETHSVREFTEKAFKVVGITIKWQGEKEDEVGIDASTGKIIVRIDDKYYRPAEVDLLLGNPSKAEEKLNWKREVSFNELVEEMVNADVKMASTMVADQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC46</accession>
    <name>I4YC46_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_18879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958419.1">
        <property type="nucleotide sequence ID" value="XM_006958357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC46"/>
    <dbReference type="FunCoup" id="I4YC46">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC46"/>
    <dbReference type="GeneID" id="18470782"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18879"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="InParanoid" id="I4YC46"/>
    <dbReference type="OMA" id="NRHRCLE"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="108"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="355" mass="39884" checksum="A81032847DB33B6A" modified="2012-09-05" version="1">MSIESRPDLLKHYLKLDQGKKIQAEYIWIDGDGEFRSKTTTCDQKINDIKELKEWNFDGSSTNQAPGHDSDIYLRPAAFYRDPFRGGDNILVIAECYNSDGTPNKTNYRHHAKKTMDLAKGEEPWFGIEQEYTILDTDNYPLGWPKGGFPAPQGPYYCGVGAGKIFARDLIEAHYRACLYAGIKISGINAEVMPSQWEFQVGPCSGIEMGDQLMLARFILHRMSEDWNVKITFHPKLFPKMDLAGSGAHVNFSVNSTRMPGTGMKAIETMIKKLEGKHIEHIAAYGEGNELRLTGKNETGKITEFSSGVANRGCSIRIPRHVAEQGYGYFEDRRPASNIDPYRVTGLLVETTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCH1</accession>
    <name>I4YCH1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_28710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958352.1">
        <property type="nucleotide sequence ID" value="XM_006958290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCH1"/>
    <dbReference type="FunCoup" id="I4YCH1">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCH1"/>
    <dbReference type="GeneID" id="18471055"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28710"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_1"/>
    <dbReference type="InParanoid" id="I4YCH1"/>
    <dbReference type="OMA" id="IRTFFNM"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="87"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="38227" checksum="A15B7A30FE58EE61" modified="2012-09-05" version="1">MDALTPDTFKPILKKLTTDADSFSEDDMRAAFEHIVRPESHTAAQISAFLTALKLTQYDSKSAYIAAAATVMRSHSVQIDGLSSVSPTCDIVGTGGDGLDTFNVSTSAAVVAAGAGATVTKHGARSASSASGSADLLLSLGCSLSIEPSRLPSILSESKFAFLFASNYHPAMAHVAPLRREIGFPTIFNFLGPLMNPAKPARMVVGVAKRELATVFVDALNRLGVERAMVVRGKEGMDEISPEGETEIWELENGNVKEYTVSPASFGLRPHPLSAVKSGTPSNNANIFRAILSASTPSFDDIPKGVEIAALKDWILMNASALLVVSGQASNFGQGVVKARDSIESLKAKAALDAFKQAGQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCH4</accession>
    <name>I4YCH4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958355.1">
        <property type="nucleotide sequence ID" value="XM_006958293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCH4"/>
    <dbReference type="GeneID" id="18474912"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64287"/>
    <dbReference type="HOGENOM" id="CLU_1541313_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCH4"/>
    <dbReference type="OMA" id="SECINRG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="174" mass="19652" checksum="6EDC37A60A46BE14" modified="2012-09-05" version="1">MDYIKSWFGGGDKDAIQPPAYDPSKDKPKDLPKFDDNVSQTEKEEVGQQQATYSPYSLPPDSGLDSAQHVEMRRRIGQASLENCSVIESMLSECIRNGSFTEKRVRGCDWLREQFYSCLTEQRNALTELGYAIPGNTPERDFKIQSLADRLSQEKEKEAKEGKGPFDSQKKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCS4</accession>
    <name>I4YCS4_WALMC</name>
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        <recommendedName>
            <fullName evidence="6">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958074.1">
        <property type="nucleotide sequence ID" value="XM_006958012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCS4"/>
    <dbReference type="GeneID" id="18473827"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60232"/>
    <dbReference type="HOGENOM" id="CLU_694842_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCS4"/>
    <dbReference type="OMA" id="DHHGRDH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698793" description="Histidine-rich glycoprotein-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44122" checksum="15E815B23B3CA52B" modified="2012-09-05" version="1">MRFSIATVAAVATIFVGTQAAPQHGHAGLEHGHHFGHDEHGPRGLEGDFDHKHLQGHGHGHHDKRKDTGKFAKMLGLPAEDGLNAGGRGGSGRGGSGRGGRGSYHKRGDFHHEHHDQFHGHEYKRFEGGHHEHGHGHHGHGHDVRSGDGSGFRKRQDGGEDKKHEVVGNKKEDEDRQHEVRGFEHGHGHHEHGHGPRGFEGGHHGHHEHGHGPRGLEHGHGHGHHEHGHGPRGFEGEHHGHHEHGHHHKRQEVGFEGHGHGHHDHHGHHKRQEDEEKKHAVVGKKKEDEDRQHEVRGFEHGHGHHEHGHGPRGFEGGHHGHHEHEHHHKRQEGGFEGHGHGHGHGHGHPHKRDKMSQHEFERRIPHDKHGHHSGAMGVITSPLVLVGSALVALFNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT7</accession>
    <name>I4YCT7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958086.1">
        <property type="nucleotide sequence ID" value="XM_006958024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT7"/>
    <dbReference type="STRING" id="671144.I4YCT7"/>
    <dbReference type="GeneID" id="18473831"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60241"/>
    <dbReference type="eggNOG" id="ENOG502S5CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081023_1_1_1"/>
    <dbReference type="InParanoid" id="I4YCT7"/>
    <dbReference type="OMA" id="VQACSQM"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="229" mass="26577" checksum="1B82377DB24561A0" modified="2012-09-05" version="1">MIESWTEELRRNLLERDSKQRINESYADNYKRLLQQYHIIKEQNDTLIKASEEPSTDTNLSSTNGNKLQAALVHSLQQQLHSTRDELTNLYKGQNQSSQRLLEMNETLRERDDNLRAIEAENLSLKASVSRLSKAREDDVEGKRERERGMEALQDEITTLRLELEQIEIRNQNLKNDNAALIQRWLDRMNQEADKMNDANETIPISNNAGATTDLDTDNTDDDFTDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU1</accession>
    <name>I4YCU1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_18301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958032.1">
        <property type="nucleotide sequence ID" value="XM_006957970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU1"/>
    <dbReference type="FunCoup" id="I4YCU1">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCU1"/>
    <dbReference type="GeneID" id="18470759"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18301"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCU1"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="250" mass="28227" checksum="A68251215B50329C" modified="2012-09-05" version="1" fragment="single">RGAGNKRRAVDAFAKKEWYDLKAPSVFETRNIGKTVVNRSAGLKNADDSLKGRVIELSLGDLNKDEDQAFRKMKLKVDSIQGKNCLTSFYGMDMTSDKLRSLVRKWQSLIESHVDVRTTDGYLVRLFAIAFTKRRPQQVKKTTYAKSSQIREIRKKMFEIMTREAGSCDLKQLVQKFVPEAIGREIEKATRNIYPLQNVFIRKAKILKSPKFELGKLLEQHGGVQAATEDAGVKVAKGTDFVEPAPLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD29</accession>
    <name>I4YD29_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958172.1">
        <property type="nucleotide sequence ID" value="XM_006958110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD29"/>
    <dbReference type="GeneID" id="18475470"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68782"/>
    <dbReference type="eggNOG" id="ENOG502RY38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518960_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD29"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="525" mass="61303" checksum="655B2A81BE4803FD" modified="2012-09-05" version="1">MMEITAEQVLRYRRLLHKKDYDGAYQNSHIISTSWTGKEKEAFFRSLARRSRFRVDLISLDVKTKTQRECMDYINVLDYESHIRKERIPLADAELCHEISDKFGELEDVFSSFLIDFQNQSNTRLKKINNLKPVVQTDENFRNSQKMRRYRLRKKGLTEDQIDEKLNTPINVKDSKEFYIGQTMKKIIGNDAINAEILKLVDFHLREFLTPLIRVLVANVETRSIFLDRKEDKEEEMLEVDTGDVDIALAMTYGTSRPQSRDYEKRDYWLETETVAPPVYNIKEWIKDARTYDKNHEATATLLDLYPFSSFQSEPILPLNLPIMKKPYSYHKVFENLLKDLDEDADIEENFDNQDKEYEEYMTNTILNGLKRSSSESSALTLPSKRARFDSNVDSDIEQGVYEDGESNQADLDQDQESDERKLMVGEEKEDVEREEGDGSEGEVEEQELEPHHTLEMYDEEDLVDSDLDSVEGLDYLAKPPSHRNQENEMREGTPVSENDGNTQESTAKLRLLTGFAKTWIDYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDH5</accession>
    <name>I4YDH5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957825.1">
        <property type="nucleotide sequence ID" value="XM_006957763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDH5"/>
    <dbReference type="GeneID" id="18475412"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68503"/>
    <dbReference type="HOGENOM" id="CLU_2135464_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDH5"/>
    <dbReference type="OMA" id="HDEKEGY"/>
    <dbReference type="OrthoDB" id="3228420at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="115" mass="13188" checksum="2194AF8EFAFA9652" modified="2012-09-05" version="1">MSTKLDQMQAVHLPAVRAGGRRVSITRKHKAVAPNASEEMEDTAQTQDYPRPLNHEHHEHDDSKEGYKNRRERRKSSTSHRNFFEPLVHGYETPAMHTPNKSTMHIKQPAGRGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ2</accession>
    <name>I4YDZ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_17923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957752.1">
        <property type="nucleotide sequence ID" value="XM_006957690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ2"/>
    <dbReference type="STRING" id="671144.I4YDZ2"/>
    <dbReference type="GeneID" id="18470745"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17923"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_0_2_1"/>
    <dbReference type="InParanoid" id="I4YDZ2"/>
    <dbReference type="OMA" id="AELAICK"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="84"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="306"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="637" mass="71837" checksum="BD654733E5A7BE1B" modified="2012-09-05" version="1">MPQPPYLNGHLHSSPVCPPSRAHLPQTQLKRHKPAVSHNKPPLENFTNEQVNYSHLVPVSALDVIYAPIFTFSHFNAVQTRCYDEIIKTDTNVVVAAPTGCGKTVILELAIIKMLEGKRNQMPSTTARNMKAIYLAPTRALCSEKTRDWQAKFNSINLSVKEITGDLPFDAQSNIMDFLHADIVVTTPEKWDSLTRRWNDSPTLFNQIKLVLIDEVHLLNELRGSTLEVLVSRMRLLPIFDSIRYIAVSATAPNAGDIGEWLDSTKKAKVFEFDESYRPVQVERHVYSYKRNVSNDFAFDSMLNFKLYDILAKHMEGKPALIFCPTRKSALKAAETITNNLKVIINRRGNVPWQRPNINTSFRNTSLSRIVDYGVAIHHAGMDLDDRKSVEMLFLQGVIRVVVSTTTLAQGVNLPCHTIVIKGTRFYSCGGWKELSELDVLQMIGRAGRPQHDTSGKAIIMTEKSNYDHYKSLVSGETALESSLHLNLCEHLNAEINLGTIKSNNGAIEWLRKTFLYIRIQKNPAHYVSALNEKTASVDTSWERRLEEIVETALFELGERGLIKLEANGQLKSTGLGNIMSKAFISFKTFEKLLDMPMRANIQTLLEILCSAEEMKDVTLRAGEKKVSIEYLLSHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE11</accession>
    <name>I4YE11_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957998.1">
        <property type="nucleotide sequence ID" value="XM_006957936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE11"/>
    <dbReference type="GeneID" id="18473811"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60204"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="InParanoid" id="I4YE11"/>
    <dbReference type="OMA" id="CKRVAYD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="539" mass="61701" checksum="29384D590BEA53EF" modified="2012-09-05" version="1">MPVNKEDKISVTIVGGGISGIAQAIHLKRRLGDKLELHIFEKKNEAGGVWRDSQWPGAGVDVPIHLYQLYSDLNPWWPDLYAKQPDVITYWQSLISKYDLRPHFRYAHEFESARWDDEASLWVFQFRHRGEIVKHSSNVFVSAVGPFHKANLGVKNHEKFQGISFHSQDWRNVDFINKRVAVVGNGSTGVQVAANLAKIDGVQLTHFIRSGGYYNPKVNTKYPNWLKWTFAYVPFANVLHRFYIFTSWEKSSLANGNAWWQRYLRRGKEAKMLDYLKKTAPEKYHHALIPKYAAGLKRVAWDEGWFASLHRDNVKLLNVPIEEADETGLRLKDGEKHDFDIIIYATGYDVAGYGVGLNENVYGEDGTELATTWQKDTPQAHLGVATPNYPNLFFLVGPNALSTSWGYTIGNQTLFISKIIETIQKERLLTIEPKQDVFEAYNKELNGYLEESVYTTSGERSWYRFKGTGKPTVPSGFTAVTLWWKTAWVDYTHWVGRDRNGKQVNLSSRLVARRLLQALTLAGIYGAYISYPQLKLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE19</accession>
    <name>I4YE19_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958006.1">
        <property type="nucleotide sequence ID" value="XM_006957944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE19"/>
    <dbReference type="FunCoup" id="I4YE19">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE19"/>
    <dbReference type="GeneID" id="18475448"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68658"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="InParanoid" id="I4YE19"/>
    <dbReference type="OMA" id="IWCPHPG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="27746" checksum="F500CB5B35D67B34" modified="2012-09-05" version="1">MTSTIKYCLFDLDGLLIDSERIYTEVTNDILSKYGKQFNWTLKANMMGKHERVASEYLVSELNLPITVDDYLLLRNQKQAEAWPRLILRPGALKLIKHLLKHNIPIAVATGSRRTSLEQKMRAQPVKELMDLFGDNVVTADDITPGRGKPSPDTFLLAAQRLGATVGFNVDSNDAPTEEHLVTRKSCLVFEDAVPGAQAGLNANMEVIWIPEEPLLELYKDDPSIQGVKQTLSSLEQLHLPSFGLPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE25</accession>
    <name>I4YE25_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_45422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958012.1">
        <property type="nucleotide sequence ID" value="XM_006957950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE25"/>
    <dbReference type="FunCoup" id="I4YE25">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE25"/>
    <dbReference type="GeneID" id="18472363"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45422"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="InParanoid" id="I4YE25"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="311" mass="35791" checksum="DDAE852570C2B1B3" modified="2012-09-05" version="1">MTIKNRTFEWRAHLDSYNKINKRNLTNNLNLNNNHSRTEFSRLATTIAKDIESTTLKLQKLTQLAQRKSLFDDKQQEISELTYIIKQDINDLNSQIQHLQQYSNHQIKKSPLGEHQSNVVILLQNKLANTSIGFKDVLELRTQNIKKTKERTEKFTNLQTQQPEYVSDSPLYNSRPSSSQAHRRKQRNSDFLALDLDDAESGQSNGQPGAQQMSLVDRQSDYMNERSTAIDTIESTIGELGQIFSQLSSMVAMQGETVQRIDADVQDISDNVYGAQTELLKYYESIKSNRMLMFKVFGIIIIFFLVFILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE67</accession>
    <name>I4YE67_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957523.1">
        <property type="nucleotide sequence ID" value="XM_006957461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE67"/>
    <dbReference type="FunCoup" id="I4YE67">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE67"/>
    <dbReference type="GeneID" id="18473663"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59975"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="I4YE67"/>
    <dbReference type="OMA" id="MVRNATW"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="537" mass="59374" checksum="5F26B182C680CCC7" modified="2012-09-05" version="1">MEDRRAAYKNKGAFRQDELRRRREEQQVEIRRQKREESVAKRRNFNITDGPDSDDESVATEIDTKLAEELPIMIQNVFSDDYQAQLESTQRFRKLLSKERNPPIEKVIECNVVPRFVEFLSSPHGMIQFEAAWALTNIASGTSQHTQVVIQAGAVPHFIQLLSSPVLDVKEQAVWALGNIAGDSPKCRDYVLQQQALPPLLGLLGENHKLSMLRNATWTLSNFCRGKNPQPDWELISPALTVLTKLIYSMDDEVLIDACWAISYLSDGSNDKIQAVIESGVCRRLVDLLMHNSTAVQTPALRSVGNIVTGDDLQTQVVIASGALPALLSLLSSPKDGIRKEACWTISNVTAGSPHQIQSVIDANIIPPLLNILQHADFKTKKEACWAISNATSGGLQEPSQIRYLVQQGCIKPLCDLLKSMDNKIIQVALDGLENVLKVGELDRESNGPGSINQYAQFVEEAGGMVTIHNLQHHENLDIYKKCFFLMDKYFPEDDDEDVAATGMSGTSGPQVDAQGSYAFNVQPSAPMGGFNFGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE78</accession>
    <name>I4YE78_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_56948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957533.1">
        <property type="nucleotide sequence ID" value="XM_006957471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE78"/>
    <dbReference type="FunCoup" id="I4YE78">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE78"/>
    <dbReference type="GeneID" id="18472873"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56948"/>
    <dbReference type="eggNOG" id="KOG3601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064552_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE78"/>
    <dbReference type="OMA" id="EWWKGRN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="33356" checksum="9CDB09A139608874" modified="2012-09-05" version="1">MNEPLPSLLSRRAEKMADNVDFLLTQGVLNASDARLIKLKLSNPNNSSTSLVGPPSAGLPNQQTGFNSSNTSLPSVSRRASLSLRNNNNKDSPLPSPPGAPQPQMLPIPTTVQPQVQPPPAQVHAPPPPPPQAPIPVVPPQPALNKCTARWDYSGEASDLRLVKGDVITILEEVNADWWRGRSDSTGQEGLFPSNRVERVSQPLRGLPPAPPSSTFGGTGEKEKEKDESYAPAYNAPPGISYGGPNYANAPAYPQPGQYYTPPAAPPAAGPTTYVQQPDEQKKNNKFKKLGSTMGNSFAGGVGFGAGAGVVSSIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE83</accession>
    <name>I4YE83_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_16975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957467.1">
        <property type="nucleotide sequence ID" value="XM_006957405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE83"/>
    <dbReference type="STRING" id="671144.I4YE83"/>
    <dbReference type="GeneID" id="18470712"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16975"/>
    <dbReference type="eggNOG" id="KOG3946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045003_1_0_1"/>
    <dbReference type="InParanoid" id="I4YE83"/>
    <dbReference type="OMA" id="THWAYQK"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="52"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="319" mass="36616" checksum="7A363664D62CAE97" modified="2012-09-05" version="1" fragment="single">HLNSILIPRVSDTPNNTQVLNYFVNHFSRLRWDATIDTFQSNTPLGRKTFNNLVVNSNKDAPFRLTLAAHYDSKYFKNAEFLGATDSAFPCALLLDLATFFTPILNKSNFTTSYGPSFDGRQLDEHDLSLQMIFFDGEEAFENWSDNDSIYGAKHLAETLSTSYIDIQEAHHPPVSKRRLKPHPTELDRIDHLVLLDLLGAPNPTIPNYFSTTEWMHSHMIDIENRLNSIAETPTVDQSNNFQSRFFVNRTSRSGISDDHLPFLHRGVPIFHVIPNPFPSVWHKLSDDRSALSIPTMSRWNAIMRTFIAEYMQLRPLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE98</accession>
    <name>I4YE98_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957548.1">
        <property type="nucleotide sequence ID" value="XM_006957486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE98"/>
    <dbReference type="FunCoup" id="I4YE98">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE98"/>
    <dbReference type="GeneID" id="18473672"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59996"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE98"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="410" mass="46922" checksum="33FD758BDE4021D3" modified="2012-09-05" version="1">MPAVDQNKPITEQTPSKKVANQLENKLNMVSPVKKPSFGEQPNGRDQPEEEEEEVVDANNLDLSGYTAEELRGKYFVGDVNCKEEDEPLLKENPRRFVLFPIQYTEIWQMYKKAEASFWTAEEMDLSKDITDWQNKINKDEKHFISHVLAFFAASDGIVNENLLERFSSEVQLAEARCFYGFQIMMENIHSETYSLLIDTYIPEAEQRDYLFNAIETIPCIKRKADWAVKWINDEKASFGERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFGHLNRRPHPKVVEKIITEAVTIEQEFLSDALPVALIGMNAKLMCQYIEFVADRLLISLGNDKYYNATNPFDFMEMISLQGKTNFFEKRVSDYAKAGVKADDTAGKGKEFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEA8</accession>
    <name>I4YEA8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957557.1">
        <property type="nucleotide sequence ID" value="XM_006957495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEA8"/>
    <dbReference type="STRING" id="671144.I4YEA8"/>
    <dbReference type="GeneID" id="18473677"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60002"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515070_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEA8"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="529" mass="59609" checksum="E3A68DDE8ECC46D4" modified="2012-09-05" version="1">MHEDRNKNSRCYIFTLDSLSGTHRPVINNLSRYLQMEAQGRKGLPLESFSVPDGKNPKVPKQPNWCDCGVYVIHYIDVFFKDTTKYLGLLLNSHKTRREHSDPQWEDKAAERAREHLVKSLDEEAVKFDAEEIRKGRREPKKVVEQKAENTTEESTESISTKGNVGQSTVLAIPAESNNNGSSNEVEKRPTAQGEDIHETSSNGSKSDSISSKVQEKLNINNQDIQRGTKKHSNLNSSNSKSDRSTMIDDNAKILSKQHNEMGTLPSKSAVIEPHIGQFGTANQASRTDQPIRTVMEKIRRAQSPQANSSQEISPDKLLYDAYNTFNQESIANWQLKGSSKSDAPQLKPQHRRVSSNPIKRDTVKTSPVSKLSNSQAAEMALSDNSPDLLRSQINSRLPKYTTRDEEPVNTNSGHEIDETVMRGQTNERSTMFKPFDTPYRHNPPLEGQLTREPFTQKHLRWEGEKDDSPECQIIVSPGVNRTADYLKPQSSPIIEQLDESGVEGRRRLEPIKQHGVDVSNPRLSPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YES7</accession>
    <name>I4YES7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957709.1">
        <property type="nucleotide sequence ID" value="XM_006957647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YES7"/>
    <dbReference type="FunCoup" id="I4YES7">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YES7"/>
    <dbReference type="GeneID" id="18473732"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60086"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="InParanoid" id="I4YES7"/>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="26169" checksum="807A0AA7ECEC0C4C" modified="2012-09-05" version="1">MAVKSARRPPQSSKPSGKCSMKWLILASIIGIFCVIGSVLEGMLDRFYIFSPEQLNEVAQNALARQSDTRGVIDDIVRQLKVSHPGRTINTREEWVFNNAGGAMGSMYIIHASITEYLIIFGTALGTEGHTGRHTADDYFHILEGEQWAYEADSLTKEVYPAGSVHHLQRGVVKQYRMPDTCWAMEYARGWIPPMLPFGYADTFFSTLDIQTLWHTSVITGREIIANLLHGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF09</accession>
    <name>I4YF09_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957221.1">
        <property type="nucleotide sequence ID" value="XM_006957159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF09"/>
    <dbReference type="FunCoup" id="I4YF09">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF09"/>
    <dbReference type="GeneID" id="18471368"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31783"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="InParanoid" id="I4YF09"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="265" mass="29019" checksum="3625443FB408F205" modified="2012-09-05" version="1">MVFRNSYDSDNTVFSPQGRLHQVEYALEAVRQGSAAVGLRSKTHAILLTLKRSTGELASYQQKAFKIDDHLGIAIAGLTSDARVLSNYMRNQAMSSRLLYGRPIPVGRIVSQIAEKAQLATQQYGRRPYGVGFLVIGQDETGPHLHEFSPDGNAFEYVAMSIGARSQMAKTYLEKESDNFEGSDLNTLINHGLQSLKASLQQSKTLTPLNTSIAIVGPPGPNEQGVKAEGSFRILEGDNVKPYIDALGQEEETQQRTTGDVTMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF71</accession>
    <name>I4YF71_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_16541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957164.1">
        <property type="nucleotide sequence ID" value="XM_006957102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF71"/>
    <dbReference type="FunCoup" id="I4YF71">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF71"/>
    <dbReference type="GeneID" id="18470699"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16541"/>
    <dbReference type="eggNOG" id="KOG2475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="InParanoid" id="I4YF71"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="700" mass="78452" checksum="BEA93A4BC6391C87" modified="2012-09-05" version="1">MLLAPPDTSNPHEQSYGTAYKEIVNTSRKRQSSANAVVILASPDVDALCGVRILVDMLKIDGILHNVRVVNGYKELETIRSEIVEDPELHSVIILGFGSLLTLSAQFSLHSGVTIHLIDSSRPWNLANAFGGFGGVEGDEAKVLVWDDAYYDAKEMEDLRKSWEALEYDPEDSEEDSDDSEDSLDDESDDADEDDQQSDEDGNPPAKRAKLNPKVGSYSLFISDSRKKMKQERHLHRSKMSKYYSNGTSHGMSVSCVMYILTVELERAVNDLVWYAILGLTYQYTSAQISRSQYDDRYVLLKDEVSRLNPPTIGETKTNPDDYSISVKEELRFPLLRHWSLYDSMIHSEYIASKLGIWKEGGKKRLHGFLAEMGLPLVQAQQSFAHMDTDLKRALPLKVENTAPRHQLVDLSYPSFVRSFGLRSLPLAAADAVEAINALLQAATGISIYVDDGQGGGEMFSNVRLWEITSLFGNTIDNKENKRNLTFFGQMEEGDEDIAALIKKRNDERSWERNFWIAYDALNNNVSRLRASIPLCISLHRAILRTGASLIEQKVIKNLSLFRLAILKEGPDLALFCNPAPLSRLAKWLIEALRDRIVSKTKGKVVDLKTGSQKRLKDLPFIVACLNEKTGTYLVAGVTGSTLFDDARKNKLGTIFYESAEATRARSKHDWFDTAIVEIHGDDFQGFIEGVQAGLAENNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFI0</accession>
    <name>I4YFI0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_44409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957383.1">
        <property type="nucleotide sequence ID" value="XM_006957321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFI0"/>
    <dbReference type="FunCoup" id="I4YFI0">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFI0"/>
    <dbReference type="GeneID" id="18472329"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44409"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFI0"/>
    <dbReference type="OMA" id="THFMGRR"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="212"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="508"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="607"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="725" mass="80071" checksum="55CF6DBA23C1F0C3" modified="2012-09-05" version="1">MSRLIVKGLPTTADNNALRTHFGSRGATITDAKVVFKKGTAVGTSKGKSRGFGFVGFKSPEEAKEALHFFNKTYWGTSKLEIEIVEDNKSIQEQLQDGKALKAKRRRKEGKESDSEEEESNKRVKVLKPVHLKAIEMQKAKNKATKNSDSEQEGGDDNTEMSDLEYMRAKMKRRHIPEETDEAPKEETPQETTQDAEARKQAEVIDQVMETARIFLRNLPFSCTEDDLKTEFSKYGVVNQAHVPLSNDSKTPMGVAYISFASPNAAVAAFRAADGSIFQGRLLHVLPAVNKRPPQDLSKASFKKLRNKDRKEGAESREFSWSGLYMNADAVVSSLAARLNVEKAEILSSDSSSNPAVKVALAETHVINETKGFLKEQGVNLDAFSPENRGPRLENTLLIKNIPFGTSVDDLDEMFRPCGEISRLLLPPAGTIAIIEYLLPNDARTAFKKLAYKRVGNSVLYLEKAPNGMWAKDAPSGAIAAGGPKPVEVVDKETPTDKVAAGEEEAASTLFIKNIAFSTPEAKLASIFSSLSGYRYARIQTKPDPKSAANRLSMGYGFVGFDNEEHAKDALASMQKYVLDGHSLQVKFAQRGKDSEPGAAMGQTKTTKMLVKNVPFEASKKDIRELFGMHGQLKSVRLPRKFDRKTRGFAFLDFVTRRDAEIAYESLKHTHLLGRHLVLQWADDAAINDIDALREKTASSRSTNMPTNKTKFVGPEGLALEELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFP2</accession>
    <name>I4YFP2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_36890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957439.1">
        <property type="nucleotide sequence ID" value="XM_006957377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFP2"/>
    <dbReference type="FunCoup" id="I4YFP2">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFP2"/>
    <dbReference type="GeneID" id="18471986"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36890"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFP2"/>
    <dbReference type="OMA" id="WLMKSFP"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="40701" checksum="9721367BA0285FA9" modified="2012-09-05" version="1">MLDDSKKEYLRHSGLNLLYIVLWYLFAFSLSLYNKWIFSSSFPFPLFMTSWHMLMQWLLSWMLLSIVPSLRTTTNLSTIEYVKKIVPCSLSTALDIGLSNLSLKTITLTFYTMCKSSSLIWVLLFAFIFRLEKPSFSIAGIILVIAVGVIMMVSAETNFVLSGAIQVLLATAAGGLRWSLTQILLKNSQNGLNNPVIILYYLAPVMFACLIILSLIFESWSDIAQSDYFIHGTLSTIKSIVMIVSPGFLAFGMVLSEFKLIARSSIITMSIAGIFKELLTIFLSSVIFGDILTPINITGMAITIIGILIYNYLKYYQTMNAKSYEQVQTNEPIFDLEDINVSNPTENTSIPQESISNSTKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS1</accession>
    <name>I4YFS1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956866.1">
        <property type="nucleotide sequence ID" value="XM_006956804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS1"/>
    <dbReference type="FunCoup" id="I4YFS1">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFS1"/>
    <dbReference type="GeneID" id="18473465"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59628"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="I4YFS1"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="344" mass="37349" checksum="87A36D032DB99992" modified="2012-09-05" version="1">MPAINTGKVLVTGASGFLAVTLVESLLDAGFEVRGTVRSSSKGEYLLHYFNNRRFNFIVVPDSVVDGAFDDAVQGMDGVIHTASPFHFNASHPNDLILPAVNGTLNLLKAAHEYGNNTLKRVVITSSIAAIFEPTTEEVVFTEESWNEFSIRQVNEKQDKATPADIYRASKSLAEKAAWEYVASAKTSFDIATVNPAVIFGPPKQQISSADQLNTSTAMFYNFLIGKQQSLGAAGNFVDVRDAAKTHLLSLTKEVAGGQRFISNSDKGGFTWQDVADVLHEKLPNDDIVKNRVLRGSPGAGVNVKQMGFSNNKAQELLGQSFTPFEVSVVDTFHSLCNLEKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS5</accession>
    <name>I4YFS5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMPKBI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956870.1">
        <property type="nucleotide sequence ID" value="XM_006956808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS5"/>
    <dbReference type="FunCoup" id="I4YFS5">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFS5"/>
    <dbReference type="GeneID" id="18473467"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59633"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033562_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFS5"/>
    <dbReference type="OMA" id="CKSEECF"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="22760" checksum="E9DF364E1463C081" modified="2012-09-05" version="1">MTRSEGDFVTCVKLPPGHHRIVFVVDNNWRVSDDLQTATDDDGLMVNYVEVPKIGDKMEHSKEVNNTRIITPQQDNFIDLSHQDPTLAHEYTSDIPQMLINYANLESSPPSSPQASNIPLPEPPMLPRQLERVVLNTQPPQLASSSSNPVPHGGTLDDNSVLPIPNHVTLRHLTASAIRGGVLAVGTTTRYRRKFISTVYYTSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU2</accession>
    <name>I4YFU2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956886.1">
        <property type="nucleotide sequence ID" value="XM_006956824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU2"/>
    <dbReference type="FunCoup" id="I4YFU2">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="GeneID" id="18473473"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59642"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFU2"/>
    <dbReference type="OMA" id="FVQFNHQ"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="189"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="404"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="797"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="876" mass="97541" checksum="8A41C71D5FD6FAC5" modified="2012-09-05" version="1">MSASAEEANSSNTGTFVAALVLNGAVAFVQVSAFCVLRPKFPHIYEPRVTKPPVRHRATALTKNMFTWAVEVFKAPYKPIARHNGLDSFMFIRFLRMVIKMFVPMWLFSWALLFPVDSANSGGTEEGLNMFTYGNVATSNHPRYAAHLLTSWIFTFWIFYLIKSEMTYFINARQSYLIDKEHSSLPQANTVLITGVPQSQLTVEKLTSLFSHLPGGIKKVWINQNLKKLPEMHEDRLKACNKLEGAITKLIKTANEMELKRGKAEQKGKPAPKKTIVDDVEKEDIGAAEKLVPSKQRPTHKLGFLGLFGEKVDSINWCRDEIARLNEEIDDKRKEVLSNPDDYKPQGACFILFNQQLAAHLCAKSLIHHAPYRMVEKYSEVGPEDVIWTNLNVNPYERKLKIVASWSATIAITIFFAIPVAFAGMVSNVDSLSSQYSWLGWLGDLPDPVKGIIQGAFPPVLVAILFALVPIIFRLLSKFEGTPRNTAVELSLMHRYFFFLVFNGFLITTLSSGIISALGQLASADVTYYPQILANQLPGASIYFITYITLQGLSGSSGGLLQIGGLVVYYIKAWLLGSTPRARWAIFNTMPGVAWGTLFPPLSLLVVITVAYSIIAPVMNGFGAVAFMLFYFTYKYNFLYVYDISPTSDTGGLFFPKAIQHIFTGMYISQICLAALFFLAKSDDEQVAIGEGVVMVILIVITVGFHIMINNSYEPLCEALPLTLASKTWDQQGETQPLTSDNALEHNSTVDSTNEGIRESSDGSVPLAELGKSMGKVSSDEKKLGNIDESHPIDDNTPPPPFKEEVSFTHPSMSEPQQIIWAAKDEYGISDEIIAKCKKDNIIATNDRAWIHTNEKGKLNKIETKGWPPGEDHKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU4</accession>
    <name>I4YFU4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_27558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956888.1">
        <property type="nucleotide sequence ID" value="XM_006956826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU4"/>
    <dbReference type="GeneID" id="18471000"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27558"/>
    <dbReference type="HOGENOM" id="CLU_2039880_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFU4"/>
    <dbReference type="OMA" id="PKVNTHR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="121" mass="13415" checksum="17C035DC41DE909E" modified="2012-09-05" version="1">MGFKVFEEEESVENTQQPTAINKQTLNVLGTRNIQKSSSAPSKLENVATEKVQRGPKVNARRQALADAAALPPKKQIAQLKKSSIKKTEGMSADEIRRLRRAELLRKQGVLSDTKKPSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW8</accession>
    <name>I4YFW8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956909.1">
        <property type="nucleotide sequence ID" value="XM_006956847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW8"/>
    <dbReference type="GeneID" id="18473477"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59650"/>
    <dbReference type="HOGENOM" id="CLU_2387864_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFW8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="94" mass="10293" checksum="281FF0A52BBFACFD" modified="2012-09-05" version="1">MDFKSTTLNGRRSSVETVKAYTLRKKSSQSNMSIGSSNNSFRSTSSSSSKSIKSVVVSPPRLSSKHYGISSRTNTPDPFSSTSQTSWFSPEFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG99</accession>
    <name>I4YG99_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_50503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957031.1">
        <property type="nucleotide sequence ID" value="XM_006956969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG99"/>
    <dbReference type="STRING" id="671144.I4YG99"/>
    <dbReference type="GeneID" id="18472531"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50503"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010669_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG99"/>
    <dbReference type="OMA" id="KYAYMHH"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="7">
        <location>
            <begin position="544"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="670" mass="76476" checksum="3BA4F231B1EBB7CE" modified="2012-09-05" version="1">MEADTRAVSVSRRRLPKKSTGSYLPSFDWDIDNGNLIRTQAFQACRNSLHARAHEVMARLLEGVADDAFEVLQSSPDIEIVDEIPTCVLISHEPTSNLVILKRLKDLTDSADFITLELGWQEFGSTPSLQNGIKSIVAGILDKYAEESNLKSYINHTLNISDFNTIYRWYEDTFSDEIKPKIVLTLRDFEALPPPLVQDFISLLSYYRKLIPVHLVICVDSSPAAVYRLLPRYTIIQLAMSQVAAPSANETFEAVIGELFFSIYYDAPFALDSTAYDVLFDTFNHSQNSFEHLLHTIDMQLLDHFFQPHSIFFNTDVLHSNMIKDDKVWRYVLSLSSTISYLRQGRDAVDHNLCKEILAEKVNSKGLLKSLVRLRKAFTKSLADENDAFQALIFLRSFIHSVVPDSKEFIPNKRALMQGKMHGELSKPISRAVQNISLMSKTQLYDWLGGYLATYPQGNSQKLANKQLEKFEETFVDNNGEVKLKNKDHTTRDPKFVEFAENCANDWTEFFTSTLIEEKVIPFQEIWTLYTSVDLQMIVNPSPRHAILTALRHPEKLLSQHYEDISNDDVVPSTLTPDITIAFRCYTEGGKLLNLSDWFTAFKAVLNVDEEKKSEKSSKKRKGETIDEDEMEVQKQARFTQAVNELDSIGFLKKASARNRNIVARTVFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD3</accession>
    <name>I4YGD3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_16194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956857.1">
        <property type="nucleotide sequence ID" value="XM_006956795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD3"/>
    <dbReference type="FunCoup" id="I4YGD3">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGD3"/>
    <dbReference type="GeneID" id="18470689"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16194"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="InParanoid" id="I4YGD3"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="113" mass="12879" checksum="6988150CB7131E1C" modified="2012-09-05" version="1">MVDQRRVQLRTKNPYNVRSNKRRVIKTPGGQLRYLHIHKKPSVPKCGDCGLALSGVPALRPRRYATISKRQKSVTRAYGGSRCAHCVRERVVRAFLLEEAKIVKRVIKQSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD9</accession>
    <name>I4YGD9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_43962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957068.1">
        <property type="nucleotide sequence ID" value="XM_006957006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD9"/>
    <dbReference type="FunCoup" id="I4YGD9">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGD9"/>
    <dbReference type="GeneID" id="18472314"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43962"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGD9"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="96"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="34280" checksum="BFF06FEAE88AEB00" modified="2012-09-05" version="1">MYLQTYKSTSMSSFRRFRPIYRNISKDTNSRHTIYATVGGVGVTGYYLYHLEENAAGRWRFLDVTPSQERQAGEAAYRDMLRQYRRHILPSYHPTARYVSDVASRIIQASPYTIDGRWEVFVIHSPVKNAMVLPGGKIFVFDGILPMTANKDGLAAVIGHEAAHQFLRHAGERMSFGKIFVALGLGLQAMGIDFGISHALFKLILELPNSRKAEHEADKIGMDVAARACFDPSEAIRVWQRMSASDNGDRALDFLSTHPGHQDRIEKLREYLPHARKIYDSSECSQMSDFSTLSNTIANTVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH2</accession>
    <name>I4YGH2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957097.1">
        <property type="nucleotide sequence ID" value="XM_006957035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH2"/>
    <dbReference type="GeneID" id="18473536"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59754"/>
    <dbReference type="HOGENOM" id="CLU_1171393_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGH2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="237" mass="26881" checksum="456280E09469FF77" modified="2012-09-05" version="1">MKVCEAVSAAANISDTDSDIIHKIHTVTNKETTKLNHDKQDAGTTSTLTQQQLSIPFERLSQDTLTTRGTTDKMLQKRVTALEETVAGYDNLFTQLHTLQMSNKMKTIESNQKRNIAAIGELKKKATIFKKRGVSQLLSTHINERFENFGKDLDTVKINIEEAANDIDSIYTEFEEITDAINVRLDAIEHSQSIDEGVQISILKAQIEQLEKDKEDIKKDKNWFRFLLSKEIPISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGK0</accession>
    <name>I4YGK0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957125.1">
        <property type="nucleotide sequence ID" value="XM_006957063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGK0"/>
    <dbReference type="GeneID" id="18475322"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67953"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056801_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGK0"/>
    <dbReference type="OMA" id="VIMYIAG"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="162"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="400" mass="44570" checksum="7CB2B2F92C5627E8" modified="2012-09-05" version="1">MTSVISNIPKSLFIQSTVTPVGKLNYRLKHLITVIRFYLYVAPLTVVNTIKNASKRPQPATKWSLLRLVGTALARQYASSTFKWSLQPPASNPVRRRVIDTFLGDDLKSHCTEIKKVDDKYYTGECERARRFVQPASSVPSFWIYPKDKPFHLDDIHDEKVLLFLHGGGYISENPLSLPSGAYAVRETGYKCLAVHYRLSDGINAHPAPLQDCTTAYIYLTHKLGVKPSNIAIMGDSAGANAANALLFHLLDLKERQVDVDLPSFVSLVSPWGDMTSTFPSITTNRECDVLPPFSSQSELVRSHLKYAPESISNKYNSPALQESSTFKPWKENNLKVHIQIGEAEILRDEGLAFALKLIEAGVDVEFSMIEGEVHDAVNIDQKAEIAKSDFLRGLSGFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM8</accession>
    <name>I4YGM8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_35476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956521.1">
        <property type="nucleotide sequence ID" value="XM_006956459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM8"/>
    <dbReference type="FunCoup" id="I4YGM8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGM8"/>
    <dbReference type="GeneID" id="18471915"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35476"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="I4YGM8"/>
    <dbReference type="OMA" id="HYPRGWG"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="565" mass="63315" checksum="88549C242B1D8F2D" modified="2012-09-05" version="1">MPPSKKPNFLLIIADDLGFSDPFGNDINTPNLDKLAKNGLTLTDFHTASACSPTRSMLLSGNDNHLAGLGQMAEFARNYPSIWKDEEGTAKPGYEGVLNYRVAALPEILNQPDPQTGKGVYRTLLSGKWHLGLTEPFLPSNRGFERSWGLLPGAGNHFKYNPDVALGVPATKTLWSDNGNLFSMDDLPDSFYSTDAFTDKLIEYLDEDYERPFFAMLTLTAPHWPLQAPRHLIEKYKGRFDEGPHELRKERLLQLHKLGLISDNAIARAHPIIDTYGKGTWDRFTEDEKKRSARTMEVYAAMVESIDENVGRLLKHLEDKEELENTFVVFMSDNGAEGSLLEALPILGERIQESIEKAFDNSFENIGNGNSYVWYGPEWAQAATAPSQLYKAFTYEGGIRVPFILNYPQGHPSLQGGAVSHEFTTVMDLAPTILDLAGIEHPGTEFQGRQIYPIRGKSWSEWLHNAEVPPHNENTITGWELFGQQAIRKGHWKALYVPAPAGSEEWELYNLKEDTGEVTNLAKTEPEILKDLIAHWSVYEAETGMVLPPPKAFADHKGYIPVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGP3</accession>
    <name>I4YGP3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956535.1">
        <property type="nucleotide sequence ID" value="XM_006956473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGP3"/>
    <dbReference type="STRING" id="671144.I4YGP3"/>
    <dbReference type="GeneID" id="18473359"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59445"/>
    <dbReference type="eggNOG" id="KOG2683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_2_1"/>
    <dbReference type="InParanoid" id="I4YGP3"/>
    <dbReference type="OMA" id="RRHYWAR"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="367" mass="41572" checksum="289707C2F3D7CCE9" modified="2012-09-05" version="1">MSSRLRNGKRLQIPSIPKPKKPSNQKEYTYDQAVELVASFLTQEKGRGKTAIVSGAGASVESGIRAYRGNQGHYELHKKYRPIFYHEFMEDSEEGRLFRQRYWARSFFGYIPVQHALPNRVHYNVAALQYMNLVDKLVTQNVDRLHHRASTDLLNPDDRILELHGTLNFAVVPNYPNHPKKLRSELQTELAALNPNWLEFANSQTKLKQNPDGDVELPSGLTYEMFKIPNPNGLEDDIRAFYKPDVVFFGESLDVRQKEESVKAIHDADRILVIGSSLATYSAFRLIKQAIEAKKQVLMINIGPTRADDYDITKIELPAADVLQGAVKLLASKLPYDETLIRLSNSGVKISLKEIDPTPDPEATEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGT8</accession>
    <name>I4YGT8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_27317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956574.1">
        <property type="nucleotide sequence ID" value="XM_006956512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGT8"/>
    <dbReference type="FunCoup" id="I4YGT8">
        <property type="interactions" value="826"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGT8"/>
    <dbReference type="GeneID" id="18470987"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27317"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041451_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGT8"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="380" mass="41898" checksum="7229096A89453341" modified="2012-09-05" version="1">MSQEKKVEETGLNDIVITKYKVAADIVKRAFDQITTKTVEGAKVIELCTTTDKFIEEEASKVFNNKKPIPPKGVSFPTCVSVNNIISHFSPLASDPETSSLELKNGDVVKIQLGAHIDGYASIAAETIVVGASAENPVTGRKADAVQAAWYAAEASIRQMKVGEKNWTVSETVNKATKPFETAAVEGMLSCQMTQNVIDGKKRIILNGNPQQKSDLGTHTFEEGEVYGIDVLVSTNKDNKPKDSSYQTTVYKRTDQTYILKLATARRVYSEIQKKSGSFPFNLRTLEDEKRARLGVQESVQHSLLTPFDVSVDKSDETVAQFFFTVGITKNGPIRLTHPPSWLKPEFIKSDKQPDEETKQLSQAALRPKKNNKKKAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGX4</accession>
    <name>I4YGX4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_31369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956608.1">
        <property type="nucleotide sequence ID" value="XM_006956546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGX4"/>
    <dbReference type="FunCoup" id="I4YGX4">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGX4"/>
    <dbReference type="GeneID" id="18471290"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31369"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGX4"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="191"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="222"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="432" mass="47125" checksum="5745165AE55BF88A" modified="2012-09-05" version="1">MATQYKVADISLASFGRREITLAEKEMPGLMEIRSKYGPQQPLKGARIAGCLHMTIQTAVLIETLVQLGAQVTWSSCNIFSTQDHAAAAIAAAGVPVYAWKGETDEEYLWCIEQTLSAFPDGKPLNMILDDGGDLTTIVHEKFPQYLADIRGVSEETTTGVHHLYRAHQEGKLKVPAINVNDSVTKSKFDNYYGCRESLVDGIKRATDVMLAGKSAVVAGFGDVGKGCAEALRAYGAIVQVTEIDPINALQAAMSGYQVVTMEEAAPRANIIVTTTGNRDIVRVEHFEQLPDDAIVCNIGHFDIEIDVAGLKKVAKEVVNIKPQVDRYTLANGRHVILLAEGRLVNLGCATGHPSFVMSCSFANQVLAQIALWTDNASFPLGVHMLPKKLDEEVAASHLEMLNVHLTKLTDVQSEYASIPKQGPYKPSHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGY0</accession>
    <name>I4YGY0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGY0"/>
    <dbReference type="GeneID" id="18474765"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62595"/>
    <dbReference type="HOGENOM" id="CLU_1612097_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGY0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="165" mass="19455" checksum="730B49493BA1B14B" modified="2012-09-05" version="1">MRSFLSNLNLYNQPTHTVQDESNELYQQELNLWKSVDFSFDEVPGQALLDDPNKKQRLSDVDPFAKYQERNSLDYSNVSNMQPIGHNTRQFPRLSHSELKEVQLYQSQPVGSIFYKHRNSSTKKDSQVHLERLKQSAQLSDKEDNPFRDLGDKEEVTRGRKRFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH31</accession>
    <name>I4YH31_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_31412</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956663.1">
        <property type="nucleotide sequence ID" value="XM_006956601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH31"/>
    <dbReference type="STRING" id="671144.I4YH31"/>
    <dbReference type="GeneID" id="18471297"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31412"/>
    <dbReference type="eggNOG" id="ENOG502QSB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041974_2_0_1"/>
    <dbReference type="InParanoid" id="I4YH31"/>
    <dbReference type="OMA" id="IDYWRLK"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="401" mass="45631" checksum="12725582E7D842FD" modified="2012-09-05" version="1" fragment="single">MLLARSKISTYVALPLTRGILQANSLSTSSQLFAASRATSSNPGYPQSSKPTVEDVNYEKTHANSDLDLSKKTGTEGVHFQKTAPFQRIEQQTLDWNNKPLGDYLLTSPVYTKEELDSVKILEFEKKTLSDRLANALVKLLRSSFDIVTGYKHREITPDVKDKPLPWLISKGYVLSEKQWLRRFIFLESVAGVPGFVASMLRHLRSLRRMDRDGGYINMLLAEAENERMHLMSFLAVEKPSIWMRAMVLGAQGVFFNLFFVSYLINPKICHRFTAVLEEEAVVTYTRAMKEIKAGYVPGWKHKEIPSIARGYWQLPADSTMLDLVMVVRADESNHRFTNHTLSELDLNKHLNPLSLQEPDAITRGTKLGFTREESAAWLAETSRAIQEKKLEGTYEKSHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH35</accession>
    <name>I4YH35_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">WALSEDRAFT_62649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956667.1">
        <property type="nucleotide sequence ID" value="XM_006956605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH35"/>
    <dbReference type="FunCoup" id="I4YH35">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH35"/>
    <dbReference type="GeneID" id="18474770"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62649"/>
    <dbReference type="eggNOG" id="KOG2072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
    <dbReference type="InParanoid" id="I4YH35"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="300"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="971" mass="111124" checksum="E526A98129F59BF4" modified="2012-09-05" version="1">MMKAPYTRPETVLKRAEELVAVNQHTAALQSLQEIFTSKRFRSTPLTSLEPIMLRFVELCVTLRKTRSAKDGLLQYKNISQNLSVQSIELVLKRFLQLSEDKVIEAKRTVDFLHPEPQDSTVAVDDLEAAETPESILMSAVSSDQNRDRTERAVVTPWLKYLWDAYRTALDTLRNNARLEILYQQIANEAFKFCLQYSRKTEFRRLCELLRSHVANVSKYAHQAHSINLTDTETLQRHLDTRFAQLSAAVDLELWQEAFRSVEDIHNLLVMAKKAPKSAIMAEYYEKLTRIFLVADNRLFHAAAFSRYYGLAQFTVADDAQHEKLSDYVLLSALAVPVHSSSTEDAVRANQKLSSILSLQKVPTRGSLLKDAITKGVLKRASADVRMLYQLLEADFHPLNVCEAIAPVIASISKNEDTKKYVEPLQNVVLTRVFEQLAQLYDNVEITYVLNLVKPLGRNSEKEVEKFVIGSCAIGGLKVRIDHVKKSIAFQEDIFAHSKANEVATEESSKLQPTPADLVRYQYARLSDVLQQTIYTIDKPSIEKAQKQQEDAFAYALANMEEERKHYLYRRAIVTRRRELAEEDSARREKEDSEARAQRAKLAAAEQTKREQEEGIRKEQERIRREMEQIRIDEAKKLAQNLAEKSGLKVDVNNVDELDTNKLVALQVEHHKKEQDQMSEKLRVMFKRMDHLERAFRREEKPLLAKDFEDQQKNDKAMYDTKVKETNRLAKETFDQTLANKQRLQRIGPSYQSYKSELEAKFSNQRKEAQRKADEAIQKEISERREKVAEQKRLEKEHEEAQKAVAQAQEAERAQAEENERKKREALMADKERSELEASQRRAEREEERRKTEEFARKQAEREEAAMKKQRETTFQKTGSVWGSGARPTPSGGSTGSAPQPGGWLAARRQAMAEGKIPTRPSGAAPPPNPNSRPPPGRGGDEKPSAFGNMRRTGSNTPPSSAPPPNPQRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH56</accession>
    <name>I4YH56_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane proteolipid Pmp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956685.1">
        <property type="nucleotide sequence ID" value="XM_006956623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH56"/>
    <dbReference type="FunCoup" id="I4YH56">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH56"/>
    <dbReference type="GeneID" id="18471299"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31430"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_6_2_1"/>
    <dbReference type="InParanoid" id="I4YH56"/>
    <dbReference type="OMA" id="VHAIWVI"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="60" mass="6800" checksum="7CAD6164F097F987" modified="2012-09-05" version="1">MFNMISAIYLLCKIIFAIIVPPLGVFLERGCAADFWINILLTILGYIPGIIHALYIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHA7</accession>
    <name>I4YHA7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_31462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956733.1">
        <property type="nucleotide sequence ID" value="XM_006956671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHA7"/>
    <dbReference type="FunCoup" id="I4YHA7">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHA7"/>
    <dbReference type="GeneID" id="18471307"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31462"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="I4YHA7"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="22736" checksum="B6E2F9A927DF6804" modified="2012-09-05" version="1">MSIMEYNGGSVVAMRGKKCVAIAGDLRLGNRNMSLAANFEKVFPITQKLFVGLPGLASDVLTLRDTFRFRTNMYKLKEGREIEPNTFAHLVSSTLYERRWSPYFVEPVVAGLDPNNGEPFIAATDLIGCLNFAKDFVVSGTASDKMFGMAESLWEPDLEAEDLFETISQTLLNGVDRDALSGWGAVVHVITPEKMITRSLKSRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC3</accession>
    <name>I4YHC3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_31468</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956746.1">
        <property type="nucleotide sequence ID" value="XM_006956684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC3"/>
    <dbReference type="FunCoup" id="I4YHC3">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHC3"/>
    <dbReference type="GeneID" id="18471308"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31468"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="InParanoid" id="I4YHC3"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="16">
        <location>
            <begin position="209"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="237"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM23365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="541" mass="60290" checksum="1B0CFD9515EC3EF2" modified="2012-09-05" version="1">MEQTKAVHDYYSTILILDFGSQYSHLITRRCRELNVYCEMLPCTQKLKDLNWKPKGIILSGSPYSTYDKDAPRVDPDVFNAGVPVLGICYGLQETTNVFGGKVEACDHREYGFAELNIVKNEEHSHVNKLFEGIEGSMQVWMSHGDAVKEAPKDFVVIGKTNTAPFAAIAHVEKPIYGIQFHAEVTHSHRGKEVISRFVKDICQCNGEWTMESFISKEISRIREICGDKGRVLGAVSGGVDSTVAAKLMHEAIGDRFQAVLVDNGVLRMNEAAQVYKTLKQDLGVNLKVIDAAELFLGKLAGVTDPEKKRKIIGNTFIEVFEAEAARLESEAEKELEEGKTEKGKFEWLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLADMKLKLIEPLRELFKDEVRALGRLLEIPAHLVNRQPFPGPGLAIRILGEVTKSQVQIVQHADSIYMEEITNAGLYDKISQAYAALLPVKAVGVQGDKRTYEQIIALRAVTTTDFMTADWFDFPHDVLKRISSRITNEVRGVNRVMLDVSSKPPATIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHD4</accession>
    <name>I4YHD4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956757.1">
        <property type="nucleotide sequence ID" value="XM_006956695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHD4"/>
    <dbReference type="STRING" id="671144.I4YHD4"/>
    <dbReference type="GeneID" id="18474785"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62743"/>
    <dbReference type="eggNOG" id="ENOG502QPXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHD4"/>
    <dbReference type="OMA" id="LSVNHTQ"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28904" checksum="CB337F097E0E64CB" modified="2012-09-05" version="1">MFLPTEPHLYRRDSSLSVNSTQKETLIVACVYAVVIGILWHVPFLRWLIYPFKLLTVGFHEFSHALAGKLTGAKIESIRLDPHEGGETRMRGGWSFISLPAGYLGSSLIGAIFIAVGFDSFASKIACFVIAASFLICIYWARRDWLCYLLIIIFSALLVAFWFINHGIYLRYVILFIGVMSCLYSIWDIIDDTLIRKVASSDAVQMSYAFKCIPSRGWGFIWLLQSVGFFACGIIVGIAAFKYEDQRARADMFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHJ3</accession>
    <name>I4YHJ3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_62798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956809.1">
        <property type="nucleotide sequence ID" value="XM_006956747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHJ3"/>
    <dbReference type="FunCoup" id="I4YHJ3">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHJ3"/>
    <dbReference type="GeneID" id="18474790"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62798"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_0_2_1"/>
    <dbReference type="InParanoid" id="I4YHJ3"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="247" mass="28565" checksum="E2FDB96E29033B17" modified="2012-09-05" version="1">MSTVPTLQKIEQPETILKKRKQDNKAREEKLAKAAEAKKAQKAKRAVIFKRAEQYVKEYRVREAEEVRLKRVARANGDFYVPPQSKVYFAIRLRGVSNIAPKPRKIMQLLRLLKINSGVFIKVNKATEQMLKMVEPYVAYGEPNLKSIRELVYKRGYGKVNKQRVPLQDNAIIEKELGQYDILSIEDCIHEIATAGPHFKQVTNFLWPFHLSSANGGYRQRKLLHFVEGGDVGNREKFVNDLIRKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY7</accession>
    <name>I4YHY7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Uricase</fullName>
            <ecNumber evidence="5 8">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 8">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 8"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956253.1">
        <property type="nucleotide sequence ID" value="XM_006956191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY7"/>
    <dbReference type="FunCoup" id="I4YHY7">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHY7"/>
    <dbReference type="GeneID" id="18473260"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59270"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHY7"/>
    <dbReference type="OMA" id="ATMYKMS"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="34695" checksum="CCD40EF0265C56BD" modified="2012-09-05" version="1">MTLKLQKSTLTTAKYGKDGVKILRIVRNDQWHEIAEYTITVLLEGDISASYTEADNSVIVTTDSIKNTINVFAQNSQHVLQPETFALELGLHFVTKYSHIKKAHVDLLKHRWTRICPTSENGQPHGHSFRRDGDDKRVVNAIVDASGGVDNITIDLKAGLKDVFLLKSTGSSFNNFINDEFTTLRETDDRVFSTIVDCSYSLVIPQANSRCFTIADVAKTPLDDIAESVRNVTLDTFAVDFSESVQTTLYTMAERIIEQNDLVKDVSYKLPNKHYIPIDLTFYQEKGATNDVLLPTEFPSGLITATVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI21</accession>
    <name>I4YI21_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956284.1">
        <property type="nucleotide sequence ID" value="XM_006956222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI21"/>
    <dbReference type="STRING" id="671144.I4YI21"/>
    <dbReference type="GeneID" id="18473271"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59290"/>
    <dbReference type="eggNOG" id="KOG2873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051390_0_1_1"/>
    <dbReference type="InParanoid" id="I4YI21"/>
    <dbReference type="OMA" id="RILYANC"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="98"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="281" mass="32514" checksum="EBD96A4F00B3E06F" modified="2012-09-05" version="1">MLAIRSLANKQPLVAHLSRQAIRLQHNQQNKRFLEPTPLSPKARPPKQHSDLTKKVAFGIAKLFGYNSDTSTAIRTTSDYYDICAEWDKDQLNFLKEAHLPPTFNTWFHLTNLHIWMLTVRFRALPEPLGRMYVQELINHFFIDIESRIRNNFKITQERTIKSYMMAYLEMWRGSGVAYDEGLIRGDAVLAAAFWRNIYSGRGVKEEIDSGDMELSPSGRIVREEEGIQGQAMEVGIPIYINSLVEYTRSELHRLESLDDEHIRRGIDNKTTAFGKPKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIB4</accession>
    <name>I4YIB4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956371.1">
        <property type="nucleotide sequence ID" value="XM_006956309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIB4"/>
    <dbReference type="GeneID" id="18475242"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67330"/>
    <dbReference type="HOGENOM" id="CLU_090428_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIB4"/>
    <dbReference type="OMA" id="YLPRAKM"/>
    <dbReference type="OrthoDB" id="3356042at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="229" mass="26988" checksum="82FDA5606A59426B" modified="2012-09-05" version="1">MTTLPQFYDLSLEERKSSYYVTIKTGHVDVLYAMPENGDPRLSHQFYHYSFKEHAHRSGDRQYNTDTERLRKQTRTALSELPYNNHNILQTFRRESRRLDKKYYFKSRRSLSDAIKTCYNKYLPESKAQRKRLVFAWVGNDASAPMQRERPPWAKDVDVPRALLDLKYEVVEINGYKTSTRCNSCNNPLKHCWTTNRDRTKFRTDTDQSGCATARNAGMKFLLTSNIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT2</accession>
    <name>I4YIT2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_58988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955718.1">
        <property type="nucleotide sequence ID" value="XM_006955656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT2"/>
    <dbReference type="FunCoup" id="I4YIT2">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIT2"/>
    <dbReference type="GeneID" id="18473107"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58988"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIT2"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="184"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="451" mass="51231" checksum="9CF0649B0D0176AD" modified="2012-09-05" version="1">MPLNYDKWANLELSDDSDIEVHPNVDKKSFIKWKQQDIHQKREARKAQLVKLNHELEINSTLLPRVTKIRKGVDQSGPEVFSGEVARLGSQPSNEKPNTGADNQPTYDEMMQNLFIQIWEKAREHLDNKDLLSKTLVEELQKTEDKVTARNEDIKKEISVIEEEESQKITSEGIRTGFDSSHVNKITDTKPQQPQKETEKSIEVLNPGASKPKKDDDDLPDLTTSMKRLAEVPLRQYRGMVDIISHDKALLADETTDALFVEAFNAGMENKADYALKCVNAGLFVQYCNKLGRDGVSLFIQRLTQSKEAETVFLKDVNDTHARIMERSKVLASQQSSNEGEKEQIQLMTEGDTEITFDVPEGPAPEKIVLEGDAKLQQLDPEVVKEWLNQRWEIFESFDNDFQMALKSGKLDIVNAYLGNQPVSKAEKIVQDLDRAGILNFSSTEIRDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ21</accession>
    <name>I4YJ21_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955800.1">
        <property type="nucleotide sequence ID" value="XM_006955738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ21"/>
    <dbReference type="GeneID" id="18473136"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59030"/>
    <dbReference type="eggNOG" id="ENOG502SBX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188562_1_2_1"/>
    <dbReference type="InParanoid" id="I4YJ21"/>
    <dbReference type="OMA" id="ADYNSVH"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7811" checksum="0F29E92AF289A450" modified="2012-09-05" version="1">MLQSKTLQKATQPRSTNSSPIAAMSKATAACAPVAKAYGTCVASSYEDITRGACQSEFEAFKNCVTKTMGRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJD0</accession>
    <name>I4YJD0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_30822</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955899.1">
        <property type="nucleotide sequence ID" value="XM_006955837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJD0"/>
    <dbReference type="GeneID" id="18471193"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30822"/>
    <dbReference type="HOGENOM" id="CLU_031730_2_2_1"/>
    <dbReference type="InParanoid" id="I4YJD0"/>
    <dbReference type="OMA" id="CANIRIT"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697854" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="24"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="25050" checksum="20AA4B5771177FAB" modified="2012-09-05" version="1">MFFNKSSLSVVALVATLTAPIAAHGVVEKVTIGGKDFGSDAVWQVDNNGPAATTNNMGNQDLACGPGATAPSTSASATAGDTVEFTWSSSWPHTKGPIITYLGKCSGSSCDPNSIDFYKIDEKGITDSDGTWEQEKLTNGQPVSATIPTSAADGTYIIRNEVDNLGSIPQELYPSCTTIEITGGGSGLSGETISFPPGYSDADVEESIALNNIYSVKSGYTMPGPAVASRRALLSRAPLAGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK7</accession>
    <name>I4YJK7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_30877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955974.1">
        <property type="nucleotide sequence ID" value="XM_006955912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK7"/>
    <dbReference type="GeneID" id="18471202"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30877"/>
    <dbReference type="HOGENOM" id="CLU_1769519_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJK7"/>
    <dbReference type="OMA" id="ISIWFPP"/>
    <dbReference type="OrthoDB" id="3340327at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="147" mass="16836" checksum="64E8D500CF1BE417" modified="2012-09-05" version="1">MSIVHVNVEGLQLPVLQPSGNSGLSLWFPPRQGFWYRRVSGAFALLCLDDMVLNGLKRDDALKLKGLDSTELTHENNIILKPNNHDEKELLERAQREWDRRNFLALKILFNTVSDKITISNELEIVSQRNAHLLWAAIVNSGLFDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM9</accession>
    <name>I4YJM9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_26870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955992.1">
        <property type="nucleotide sequence ID" value="XM_006955930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM9"/>
    <dbReference type="STRING" id="671144.I4YJM9"/>
    <dbReference type="GeneID" id="18470962"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26870"/>
    <dbReference type="eggNOG" id="ENOG502RS0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185821_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJM9"/>
    <dbReference type="OMA" id="RKMYADS"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="234" mass="25161" checksum="BF64C654FEE82D1F" modified="2012-09-05" version="1">MTNQSLLKKIPQSTSQTPSLQSRISGLAKRQEKNTAKAKLAKNNKIKGSSKQSIQVTILNLAAGTSADDVKVALSSYGTITSAELNPASSTNDSVAVNIYFENLDEAKAAAEAFDGLLADGKILTVKVIEQKSVDDVKDLFKDSKMYADTLPPPAPSPPKASESSVAQKEKKPPRSPKKNQLSLLERTQMQPKAQLSSQSGTQQSKKNQKASLLERINKDSFAGKTLASRFGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJN3</accession>
    <name>I4YJN3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,5-diketo-D-gluconic acid reductase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_62002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955996.1">
        <property type="nucleotide sequence ID" value="XM_006955934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJN3"/>
    <dbReference type="GeneID" id="18474702"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62002"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJN3"/>
    <dbReference type="OMA" id="NYNFLVH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="31563" checksum="C11270BE09F52F20" modified="2012-09-05" version="1">MSEIKVLTNGRTMPSIGFGLYQLARERTQEVSTKAIEKGWRHFDCARVYRNERELGETLAALPNHVSREELFITTKLDKAGTSTHACKDVRKSIRYLKSDYLDLMLIHSATPGRTNRIDAWKSLCEAYDAGLCKSIGVSNYGVKHLEELKTIEGVSVNVPHVNQIQLHPWLQNRPIVDYCREHGIVIQAFSPLARASRWSDDTIQRISQKHSVTPAQILIKWSLQHGFVPLIKTENESRLSENLLLDTDFYLDAQDMIDIDGLDTPDGACTWNPVECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJR9</accession>
    <name>I4YJR9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_67050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956029.1">
        <property type="nucleotide sequence ID" value="XM_006955967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJR9"/>
    <dbReference type="FunCoup" id="I4YJR9">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJR9"/>
    <dbReference type="GeneID" id="18475204"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67050"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJR9"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="250" mass="28041" checksum="C7559F017097A82F" modified="2012-09-05" version="1">MSLNQRKTGVELRNASSLIKQGAEAKVYLNRTEEKPMILKYRFPKTYRHPTLDKTLNKQRIQSEIKALDRADTAGVSVPKVLFADSRDSMLGLELIDGYSVREWLGSKGEGDITASDDGVKLDMTAIGLDRQTLMKLVGEQIGKLHLSGIIHGDLTTSNLILKHSTKEVYIIDFGLSSLKPINHYTSAEDRAVDIYVLERAFGSTHPSLNKEYSQLLESYADTLKSSEWNKVNSKLNDVRLRGRKKDMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y551</accession>
    <name>I4Y551_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960877.1">
        <property type="nucleotide sequence ID" value="XM_006960815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y551"/>
    <dbReference type="GeneID" id="18474660"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61652"/>
    <dbReference type="HOGENOM" id="CLU_2016984_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y551"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697403" evidence="1">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="123" mass="13524" checksum="A6274DD1CFFD840D" modified="2012-09-05" version="1">MMFKQHNIGRLAVLCCLLLVPLFTLVESAPQLPQAQPGLSAKRQESNWMDTIANVDHATGTGNIRSGLASLYAMHLFQDMCDKDENGIIKNRVERITSKVAGVIFGVYGAYRLRNGFVAQSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y574</accession>
    <name>I4Y574_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_41794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960843.1">
        <property type="nucleotide sequence ID" value="XM_006960781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y574"/>
    <dbReference type="STRING" id="671144.I4Y574"/>
    <dbReference type="GeneID" id="18472231"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41794"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507713_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y574"/>
    <dbReference type="OMA" id="SADNFKH"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="537" mass="59457" checksum="6CFDA303726DB08F" modified="2012-09-05" version="1" fragment="single">MVPQNVLLNGLPNIPNTSSNAFFDPISKLPTPPTYGPLLDIFFRDLVQFFPFLERGSVETRLQNGTMSAFLINAICAIAVKFALPEGMTPVQASMPFMQQANSLLIELLRLPTTDTVSGLLLLSYCEFGQNSESGLWQFSGMAIRMAFDLGLQNSTDDSLFESPEEARRARLLFWTLFVMDRVLAFGTGRPSSMSEDVEISLPEPPHQPPLPAFIPFAPPNHIPWCFPAAVRIIILVGRISDSLNRRDALRRRNSNDTQDVEVQNNERRQLLENQLKEFYADLPQELNWSVENLKMHAANGQGGLYLFIHVWYNAVLAFVHQHQTPGTVVTKDTFKISLSSAQMISEYLVFADLFTNQSYLASPFISQPLFIAACAFIHDARVNHNVSLGPIKKSAETNTPLSVPDLQNDKGVGLLGTISAQNFLIIYKALRRMTWPWQGIGYIVNLLEQRASVSGLDQVDFSATSDAIQSFISLPDSGIVQKHSKTPPQNPSPPTTTTATQPTATSTIAPVMEYETTVATNITNSNNTDSLDTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y594</accession>
    <name>I4Y594_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_10239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668258">
        <property type="protein sequence ID" value="EIM19136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960832.1">
        <property type="nucleotide sequence ID" value="XM_006960770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y594"/>
    <dbReference type="STRING" id="671144.I4Y594"/>
    <dbReference type="GeneID" id="18470582"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_10239"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080231_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y594"/>
    <dbReference type="OMA" id="GELFYNH"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="11656" checksum="B108DA803A3E7EE8" modified="2012-09-05" version="1" fragment="single">LSDAFVITNPRLRDHPIVMASDGFSKVTGYHHSTIIGRNCRFLQGPGTAPQSVQRIRDALNNGVSITELLLNYRADGTPFFCLLNMIPLHDSQGKIAYFIGGQVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5B1</accession>
    <name>I4Y5B1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_34251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960815.1">
        <property type="nucleotide sequence ID" value="XM_006960753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5B1"/>
    <dbReference type="STRING" id="671144.I4Y5B1"/>
    <dbReference type="GeneID" id="18471842"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34251"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y5B1"/>
    <dbReference type="OMA" id="SWGISVT"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="348"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="55240" checksum="EACB779B55647F6D" modified="2012-09-05" version="1">MISGFFKRNNSHGSSNNDKQLNSDDDDLKPPSSSSSPFRRPLTFRAFITPAYPVAPVPGYVESIRNTICYSWLNILLISAPISWALHQIHITDIGTFVTSILGVVPLAALLSFGTEEIALRTSVPLGGLLNATLGNLVEIIIAVLALVRCELSIVQSSLLGGLLSNILLVLGMSFIAGGIKFSQQSFKQLPASLNTSLLMLSVMSLMIPLAFHTILGDKFPENPTSEKSFILQMSRGTSIILIFIYLCYMTFTFYTHQEEFLDHVEDDGLISPTHPDSTTQAHVTSLSDDLEAGFKRPQLKRARTAPIIATPLMTSTSTYSGSTKCDETPRIDNKRQVEHPRLNIGTSIAILIITTILLYFTCEALVDSIQGLADSTSASKEWISLIILPIVGNAAEHATAVIAAAKGKQELALAVALGSTVQIAIFVIPLIVLLAWIISKPLTLVFEPMETVVLFLSILLARFAIEDGRSHWLSGCVLLGSYLIIALVFWYFPKSDTFEFITCMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F2</accession>
    <name>I4Y5F2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_22912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960766.1">
        <property type="nucleotide sequence ID" value="XM_006960704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F2"/>
    <dbReference type="FunCoup" id="I4Y5F2">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5F2"/>
    <dbReference type="GeneID" id="18470937"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22912"/>
    <dbReference type="eggNOG" id="KOG4100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102310_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5F2"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="12786" checksum="8D121105AF9A4764" modified="2012-09-05" version="1" fragment="single">VTMATQYVKELLPPIKLYRRLLRIHRTLPKDFRLMGDGYLRDEFRRHQNIDNPLQIIGFLSSWKIYLDQMQNPSMKQKMNLDDLLTKLSHEQVSQLYELLNEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5S0</accession>
    <name>I4Y5S0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_52848</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960588.1">
        <property type="nucleotide sequence ID" value="XM_006960526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5S0"/>
    <dbReference type="FunCoup" id="I4Y5S0">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5S0"/>
    <dbReference type="GeneID" id="18472596"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52848"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y5S0"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="27"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="373"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="345"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="492" mass="52113" checksum="6DABD2008FD08E95" modified="2012-09-05" version="1">MDKCILANNYNNTLLSLRSYATGAEPYDLVVIGGGPGGYVAAIRAAQEGLRTACIEGRGSLGGTCLNVGCIPSKALLNNSHHYEAAQHDMAHRGIDIGNVSLNLDTMMKAKNTSVTGLTKGIEGLFKKNKVDYIKGTGSFATPNKIDVALLEGGNSQVEAKNVIIATGSEVSPFPGPGLEIDEKQVISSTGALSLPKVPKKMVVIGGGIIGLELGSVWRRLGAEVTVVEFMGSVGAGMDGEIAKNFQKILAKQGVQFKVNTKVVSAEKNADGVKLNVEGVKDGKAETIDAEVVLLSIGRRPVTSKLGLENIGVELDNKGRIPVDDHYNTSAPGVKCIGDVTFGPMLAHKAEEEGIAAVELIKHGHGHVNYDVIPSVIYTYPEVAWVGRNEEQLKEAGVKYKVGKFPFLANSRAKTNMDTEGTVKFLIEADTYEILGVHIIGPNAGEMIASAALAMEYKASAEDVARTCHAHPTLSEAFKEAALASYSKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5S7</accession>
    <name>I4Y5S7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960595.1">
        <property type="nucleotide sequence ID" value="XM_006960533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5S7"/>
    <dbReference type="FunCoup" id="I4Y5S7">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="GeneID" id="18471813"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34097"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y5S7"/>
    <dbReference type="OMA" id="MGPLTPY"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="580" mass="65194" checksum="0B02EB205C77D51F" modified="2012-09-05" version="1">MDAHRCIKTAKKLDKLVILINYQFSENHFVSETLMIAGIAIKLTFIAALGDLVQANPLARATAESHAGSKTSISLPTPTADYYSRVFNLDQPYRGTVSDGILPELSIRPLAVEYPYTTDYPSILVRPVAKDAKSIDEFDVIGNWGINMPYKSSPQLLEGTSPFPPQSCRIDSVNLLHRHAERYPSSWDQSLDFAKSLSEKVQRGLNASKPIEFFDELEFLSDYSYPLGSDKLTSIGRDTMFRHGTQFGILYGRLLDSFTNHKMVVRTTTEERMYRSATNFLLGLLGEEWPDKIHLVQQIEEDGFNSTLNVWNTCNREDADQGDPRKEHWQKIYLQDASKRLSANVKNANFTVDDVAGMQDLCAYETIALGYSHFCSLFTKDEWKGYGYGYDLYHYGDAGFGGPVARASGLGYLEELLARMTNDRKNLEPYESSTNRTLNQDPITFPTDQAVNIDFTHDVTIGEVVVALNLTHFSRGLSQDYIETAEPRWKSNVISPFAANILIQTISCGEDNKEYARVILNDAVQPLSGFGKCGDNAQGMCELKLFIKALKQAKHETNFTFDCFGDFNNTHVVHNGEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X4</accession>
    <name>I4Y5X4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_58813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960642.1">
        <property type="nucleotide sequence ID" value="XM_006960580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X4"/>
    <dbReference type="FunCoup" id="I4Y5X4">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5X4"/>
    <dbReference type="GeneID" id="18473070"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58813"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y5X4"/>
    <dbReference type="OMA" id="MSVCPPY"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="163" mass="16440" checksum="7FB6E917BD565F76" modified="2012-09-05" version="1">MSDQCPVFAHFLGFGGVASAMILSTIGAAYGTAKSGVGISGLATFKPELVMKSLIPIIMSGILAVYGLVVSVLIAGSLSPSEPYSLFAGCTHLAAGLACGGSGLAAGLAIGKAGDAFVRAYVYQSRVFVGMLLTLIFAEVLGLYGLIVALILNTRISGDECSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y629</accession>
    <name>I4Y629_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_49127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960571.1">
        <property type="nucleotide sequence ID" value="XM_006960509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y629"/>
    <dbReference type="FunCoup" id="I4Y629">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y629"/>
    <dbReference type="GeneID" id="18472484"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49127"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027221_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y629"/>
    <dbReference type="OMA" id="WSLHRFI"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="434" mass="50304" checksum="B9A4B1BA26CFFD5F" modified="2012-09-05" version="1">MTTITSQPSPTRASIQLDGQSNLECKIPRYSIELEGTSNQFVSYTIQFNSNSSLYKSSNQEIQRRFKDFKFLHTQLSNAFQASVIPPLPDQHRLEYLTGDRFSNEFIQRRRTDLERFLQRLSRHPILRKSKLLIEFFTSTEWNTVMHKYNFETQSALEPPHSILDNISDSLVNAFTKVKKVDDRFLALKDNLDRLDDSLTSIEKIVVKLRTKVSSVDNTAIDVDLTGDYEDQAGATQSLAYLESGITEPLNRFAHVQLQFSTLLRDLTVTAYEPVLDHIHSLRGYANSHKAVLKLRDQKQLDFEQLTTYLSQLSVQHQRLMSAQPVIAGGIGGYIRDRVDHFRGQDDERSRLEKLRKLEEQMKELEKAVENSSKQNVEFSQAVLREHSIFDMSKRIEMKEILHQLSEGHVKAYQKTSEEFERLIPHLQRIRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y634</accession>
    <name>I4Y634_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ebp2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960576.1">
        <property type="nucleotide sequence ID" value="XM_006960514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y634"/>
    <dbReference type="FunCoup" id="I4Y634">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y634"/>
    <dbReference type="GeneID" id="18474563"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61494"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y634"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="372" mass="42025" checksum="7BC57FF7DFD6B2AB" modified="2012-09-05" version="1">MVKRKEIKNVLKLDEDEDNSSEEENYDGVTEESMQKIIQLLGEDGLDQQAKDQLAYLDQLETGKSDDLLDDEAELSGEDDEDEEENDEEEDEEEEEEDSFINDAPEDEEEDASEEEEDVALEDVTGEVDEDTRAQIKTKVVVNNKAAISRILSNIKLSDKLPFIETLAVTANQSITDYGAVDVYDDLSRELAFYKQSLDAVNKAKPEILKSGTPFTRPTDFFAEMVKTDVQMEKIRQKMLDEKSNIEASERARKQRELKKVGKKVQNEKTLERQKSKKEMVDKVKSLKRKKGGVEGLDAGDDDFDIQLEDALEGGEDKKKRKMSRNARDAKFGHGGKKKYAKSNTKESTNAPFKGGKSKNSRPGKSKRMAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y658</accession>
    <name>I4Y658_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase, subunit VIb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_34022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960482.1">
        <property type="nucleotide sequence ID" value="XM_006960420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y658"/>
    <dbReference type="FunCoup" id="I4Y658">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y658"/>
    <dbReference type="GeneID" id="18471797"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34022"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y658"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11257" checksum="857F54FEF4785F75" modified="2012-09-05" version="1">MGWWPFSSNQEKDVPSSKAKTLTREERQACWDARDQLFSCLGDKPTNDTDEIRKLCPKEFKKYEGACAASWIDYFIKRRMLEMRQQATQASNTQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6A9</accession>
    <name>I4Y6A9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_52731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960426.1">
        <property type="nucleotide sequence ID" value="XM_006960364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6A9"/>
    <dbReference type="FunCoup" id="I4Y6A9">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6A9"/>
    <dbReference type="GeneID" id="18472591"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52731"/>
    <dbReference type="eggNOG" id="ENOG502QQ87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_6_3_1"/>
    <dbReference type="InParanoid" id="I4Y6A9"/>
    <dbReference type="OMA" id="TKHYGMT"/>
    <dbReference type="OrthoDB" id="434407at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="344" mass="38391" checksum="DCE4F11A7B9AE091" modified="2012-09-05" version="1">MQQQTKPIDIVCSTNWELSPYHVPLIIAKYKGYFKDENLRVATIHPEDVSDVTEIVGSGKADLGLKAMIHTLAGKARGYPVKSIGTLMDEPFTGLLYLEGNGVTEDFRSLKGKKIGYVGEFGKVQVAELAQAYGMGEDEYEAVRCGMNISKALIDGKIHAGIGLENMQQVELEEWCKANGRPASDVKMLRIDQLAELGCCCFCSILYIGNEAWLEAHPNEARGFMKAVKRAADDLIKDPKGTWELFQEHKPSMRTTLASLQYARSYNYMRSDLANVDRDWKKVTGYAQRLGIFPQDLKPNYTNEYLTWELDDEEKVDGNAKQIEMVKKQAEVAQSGGVLVDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6G5</accession>
    <name>I4Y6G5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960355.1">
        <property type="nucleotide sequence ID" value="XM_006960293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6G5"/>
    <dbReference type="STRING" id="671144.I4Y6G5"/>
    <dbReference type="GeneID" id="18474500"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61386"/>
    <dbReference type="eggNOG" id="ENOG502S9F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1826802_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6G5"/>
    <dbReference type="OMA" id="IGWIKEY"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15762" checksum="92E0DF5AA71248A2" modified="2012-09-05" version="1">MSHEEIPLPLGWIREFDPNHQTYFYVDTQQTPAHVTWDDPRLNPLYNNLLPSQSSNSQPFTKADSPPTKQQVSDQFEITRNWFEQLTDDEATPQSSNCVKDLAAGSLGILALSAVAFKQSNVNNLQNNRTRGAGWGSGLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6V4</accession>
    <name>I4Y6V4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960204.1">
        <property type="nucleotide sequence ID" value="XM_006960142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6V4"/>
    <dbReference type="FunCoup" id="I4Y6V4">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6V4"/>
    <dbReference type="GeneID" id="18474460"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61319"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y6V4"/>
    <dbReference type="OMA" id="DQVLMDH"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="536" mass="57621" checksum="F4AFE0284B9EF815" modified="2012-09-05" version="1">MMSAVVGLNFGTGYSSIAIINKKGYADCIANEDGQRQIASALAFNGEEEYVGNQAKPQLVRNNKNTILGFRNLLGREYSQDIPQSELSANVINNNGTPSYKVTINGKEEILSVKDVTVKVLQSLANSAIEYVGKAIDGAVMSVPHNWSREKRQALKDAAKEANIPVLDLIDDWAAGMSAYNEVLGESDVNVLVVDMGEYSTSVTTVAARQGLFTPLSNLTDDKVGGQQLDKALVTHFAKEFTKQTKLNVPTEFKTDLEESDRRALVKLTLACEQTKRSLTASNSAGIAIESLKDGIDFSSQVNRLRFGILASKTFNAVGSLAEKAVKEASLEIENIDKIVLIGGSSSLPSLTNVLGGIFTNAEILSSVDPDQAIAKGSAIQAKLLFQPDVPKLPSATTQLDVGVTSAPIVLAGEGEENAVVVAQNTPLPARRIVSLNPPKGDKAFIDLYEGKHEIKVVQPPPREKSAEDEEFSDEEDDEPERIPIITRTSKIASLQVPIKNTNPITLQLIVLENASVEIRAEQQGQEPVAASVNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Z0</accession>
    <name>I4Y6Z0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_60372</name>
        <name evidence="14" type="ORF">WALSEDRAFT_61342</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="14">CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958365.1">
        <property type="nucleotide sequence ID" value="XM_006958303.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960240.1">
        <property type="nucleotide sequence ID" value="XM_006960178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Z0"/>
    <dbReference type="FunCoup" id="I4Y6Z0">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6Z0"/>
    <dbReference type="GeneID" id="18473917"/>
    <dbReference type="GeneID" id="18474471"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60372"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61342"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="OMA" id="SEVEYMG"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="15318" checksum="E56B7C7277EC28C2" modified="2012-09-05" version="1">MAPKSAEKKPVSTAGKAPASATKQPQEGGKKTAKAPKPDSDKKKSNKSRKETYSSYIYKVLKQVHPDTGISNKAMSVLNSFVNDLFERIASEASKLASYNKKSTISSREIQTSVRLILPGELSKHAISEGTKSVTKFSSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y779</accession>
    <name>I4Y779_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Voltage-dependent ion-selective channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_48538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960155.1">
        <property type="nucleotide sequence ID" value="XM_006960093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y779"/>
    <dbReference type="FunCoup" id="I4Y779">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y779"/>
    <dbReference type="GeneID" id="18472456"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48538"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y779"/>
    <dbReference type="OMA" id="KPCCSHE"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="24439" checksum="BF7EFBD8DAA68395" modified="2012-09-05" version="1" fragment="single">IEGKYVDAAKGVIFTQGWTTSNVLKSQLELENNIAKGLKLDIQSSLLPNGGGKSALAAAIYKQPGLHGRAFLDLFKGPTFTLDSVVGKDGFLAGGEASYSVQDGKISKYAAAVGYSAPEYAVTLHGLNNLNVFAASYYHRVSRDVEAGAKAIYDTKVGPSKVNLEVGAKTYLDNAAFVKSKINNAGVLALGYTQALRPGVKASFGLALDTQRLNDTSAGPSAHKIGAAFTFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D8</accession>
    <name>I4Y7D8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_58458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960022.1">
        <property type="nucleotide sequence ID" value="XM_006959960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D8"/>
    <dbReference type="FunCoup" id="I4Y7D8">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7D8"/>
    <dbReference type="GeneID" id="18473021"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58458"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y7D8"/>
    <dbReference type="OMA" id="EEHTYKK"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="153"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="370"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="625" mass="69896" checksum="C1A864AB78C79A82" modified="2012-09-05" version="1">MSAKISNPELKKYMDKRVLVHLQANRKVTGQLRGFDLFLNLVLDDASDETFAGEKTRIGQISYTHSPRLYVVTQSHQWKALKQYQKYEHGDRDKAKISCTNNLFSASTSTSFISYHHQMRRPLSLNLLQVGLTLASPIKILHKQASKPDHPPGTTLFYVQLLISVCLVLSGGLFAGLTLGILSLDDLNLKVLETSGESEVEKEHARKLLKLLSLGRHWILSVLLLSNSVVNEALPIFLDSILGGGYTAIILSTASIFIFGEWVYHKITPFLLTCYRIIPQSICARHGLAIGSFFSPLVLMLCYATSPITYPLSKLLDHVLGSQHDTTYKKAELKSFLNLHRYGVEPLQDDEINIMEACLSLNEKKVTDIMTPIEDVYTLSSDQVVDETVIDKILHHGYSRIPIHTPNNPTRFIGMLLVKKLIKYDPEDKWFVSDFALSVLPEALPNISCFQALDYFQTGRAHLLVITEHPGDMLGRGVLGVATLEDVLEEILGEEIIDESDRIMDNRTKRRVVRTHQYIKGIYERQKAVRRGSLPETSSNSRAESPVIQVKRKLGTSTPISNAMVSNPSSTAANMTNEDIVENSTDERAPLISSPAPRYPANRSRLQNSMVGSPPSDNQNNYGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7E3</accession>
    <name>I4Y7E3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_65883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960027.1">
        <property type="nucleotide sequence ID" value="XM_006959965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7E3"/>
    <dbReference type="FunCoup" id="I4Y7E3">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7E3"/>
    <dbReference type="GeneID" id="18475061"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65883"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y7E3"/>
    <dbReference type="OMA" id="QESMKQP"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="230"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="620" mass="68754" checksum="99CCFB4600AC7CF5" modified="2012-09-05" version="1">MSSPNDSLSNNYSSSPSKQNRLSHLRKDDFEDASDEYKAELLRKHLVSKEERNKSNSNSHSPYQNSQPDNNNTSTDDIEEPEEEFSAPLDVPGADITHHLYAWERQHRNSTSTRPRSMSFSNVQSAIESQSETEIDHSLGYLRHPGGFRRHHIVNKARERGDEEPEIASTTFVDYLLLFGHFAGEELEEIEELSEEDRDEAVRGRSERDSLLPKPIPVRRRSTSTARRGTASITQAVLMLLKSFIGTGILFLGRAFLNGGLYFSTAVIIIIALLNMWAYILLIHTSYKIPGSFGDIGGILYGNKMRLAILASITISQMGFVSAYTVFVAENLRAFVIAVSESNLNLPTMLFIVMQIPILTPLALYRNLTKLSLTALIADAFILIGIVYLFGQESAVLLEKGIAKDVVLFNSKSYPLFMGTAVFAFEGIGLIIPVMESMKEPKKFPYVLSGVMVVLTSLFAGSGFLGYAAFGSQIKTVVISNLPQDDKFVQIVQFLYSIAILLSIPLQLFPAVRIMEAGLFVRSGKFSNKVKWKKNLFRLLIVFICIVVSILGANDLDKFVSLIGSLACVPLCFIYPPLLHLKACARSTYVKAADIAMLIFGVLLVVFTTTLTIASILAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Y4</accession>
    <name>I4Y7Y4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959797.1">
        <property type="nucleotide sequence ID" value="XM_006959735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Y4"/>
    <dbReference type="STRING" id="671144.I4Y7Y4"/>
    <dbReference type="GeneID" id="18473007"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58322"/>
    <dbReference type="eggNOG" id="ENOG502QWDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323946_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Y4"/>
    <dbReference type="OMA" id="SMEQGWI"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="295"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="735" mass="82727" checksum="1EBEBB4F75DE9D6D" modified="2012-09-05" version="1">MLMLGATKKRGPPKGYIDTLSDKLGRLEIVITRLAKLPNASGILDSIRTQDAITASIVDSILDKQLHDAVPTSAVNPTQRRRLNSLQSLQLDVKPQIEELEDSSDEVTDSLGQLSIDENSNIRYHGKASGLHLITNNKRHEQGIWNFPAPGIWPASHELKKLTQKEVVRLSGAKQCLPDIQVQDKLIELYFSYVHPVIPIIHKGWFMTNFKAPENDERADELLPTLLLLCVFGVASRYSAVNNPESPALWAAGTLYIERAREIAHLDHPNSRLSSVQAFLLLTYRSVGLGDMKSAWMFLGHSVRMAEDLGLHRDVSHFHPNGRLRLSDVQVEARKRTWHGCVILDTYISSYIGRPTAIRAKDYDTRGCKEDEIEESEAWQPVEAHVTCSRDVCDLSDQDYPFNWAIPQTGHALSCFNQLSKLSALENKILESCYSIKEKTNSEAAQMSLHELHKSVDKWSIDLPRHLKFQASSQRLPPPNVLTLHTAFHCTLILLHRPFVDIPSHYPSHQIMTMAANSITSIVNSLNHRHDFLNKAPSLLIYHVFTAGITHCFNLKYPDIEPVARQNLTKTMEALKAMVITWPAAGRAYDMLTDVYDIQQNQSLDEITDNGPRGIKRMMMESTEQQANMGINFSDVFPCPTEPLLPQVPTRHPGVSTLNNELSDITSEGPFTGSYYMGMQQPTMLPGHNLGSLPPIVSGPLPHMPNFHSPNEQIRRQSQNFYDFNTPSQTQGWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y816</accession>
    <name>I4Y816_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_70079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959829.1">
        <property type="nucleotide sequence ID" value="XM_006959767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y816"/>
    <dbReference type="STRING" id="671144.I4Y816"/>
    <dbReference type="GeneID" id="18475683"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70079"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y816"/>
    <dbReference type="OMA" id="STWHETH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="16015" checksum="4F29493B48F68F1E" modified="2012-09-05" version="1">MCSYFRTASKCTSIMILLNSVADLSKCGPCHAIAPKYEALSKQHTNVNFFKCNVDTAKDVAAKYRISAMPTFIFIKSGQVIETIKGANASAIENALGKHSGGGSFSGKGQTLGSASGSTSSANDSFNSHLYIGMALLALYTGLWYYNVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y850</accession>
    <name>I4Y850_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_48104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959863.1">
        <property type="nucleotide sequence ID" value="XM_006959801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y850"/>
    <dbReference type="STRING" id="671144.I4Y850"/>
    <dbReference type="GeneID" id="18472441"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48104"/>
    <dbReference type="eggNOG" id="KOG3456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083053_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y850"/>
    <dbReference type="OMA" id="TPFANEH"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="141" mass="15427" checksum="E54E7DEE53EFBC99" modified="2012-09-05" version="1" fragment="single">MFARQISQTSKRTLRCGYSTSVVPPRSAVNTSQERGNPVAELPGQAEDRATKWSPRQRSKEDAYVGARFEQKHLGLQPNPKAAIELIAQEPVRLVEGRVASCDGGGGPLGHPKIYIKLDKPGAHACGYCGIRFEQAHSEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D8</accession>
    <name>I4Y8D8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_33470</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959718.1">
        <property type="nucleotide sequence ID" value="XM_006959656.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y8D8">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8D8"/>
    <dbReference type="GeneID" id="18471687"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33470"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y8D8"/>
    <dbReference type="OMA" id="FSCFQYM"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1285"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1371"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1402"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1439"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="308"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="468"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="562"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="1285"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="177"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="879"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM20230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1499" mass="166933" checksum="3FE5E749B6916B0F" modified="2012-09-05" version="1">MTSRDQNGDVNEIDFYTPLASEQRDDIEEYDDNHQDYTEGADDKEIESVGLDIAHRRRESQLENLSDGYSGSIFGGPDNVSIPSSVVSFRHGLGGSSHSRRPSLTHRSSFGSAISDGSDNTRPFYRRGDRSASRSRTRRDSNDSSNSPLLTTSSPPLSASKGSGMFSGIAAIFGSKNDEEMTRRRPQASRTSSVGHIGSDGSHISDTDWGYSSNEEISDENDDISSEMASSAAASLNDSESSSVASSRRRRSNDFLPTGTFAPDPVFGDTRIPMEISQEETINPDLEFFAKSDKQGCQSRQKIYIQEEDVSLLIIGFRRSTFGHLLWSLGVVLTFGLLSLIGRWIPSLWLRLASIEAPFVSESGDNQATSIIVETQFGHVNIYKIDSMPFPYPISSIFPHDTMHFTPSINKTKTTETVESAGTSNSSSADILRFFDYRYTRFILHEDQGVFRMIRDWRDPRWISQTAVAGGLPESKREERRLLFGLNEIEIEERSWGQLFVDEVLHPFYVFQVASIVLWSIDDYYYYAFCIAVISISSIISTLLETKRTVKRMKEMSKYSCSVWLKSNNEWQVVDSTSLQPGDIFDAADPNLHTVPCDAILLNGDAIVNESMLTGESVPVAKVPISDSLLRTYAKTEPKGTTDISPNLARHFVYSGTKIVRVRGEGILPNGQEGPALALVTRTGFNTTKGALIRSMLFPKPMGFKFYRDSMKFIGVLAGIAFLGFLASSVNFVKLNIAWHTIMIRALDLITVVVPPALPATMSIGTSFAISRLRRKGVFCISPTRVNVGGKINVVCFDKTGTLTEDGLDVLGIRSKEDATNRFSELYQYATEMPHSKENQALLYALATCHSLKLVDEQVIGDPLDIKMFESTSWTLEEGKIGSRPTEHQSNETAQKQPDKKGKGKSSRIPKRPSALVQTIVRPPGGKNLSSATSKSFLELGVIRTFDFVSSLRRMSVIVKRLKSQSMEVYVKGAPEVMSDICDKDSLPEDYEDLLSYYTKHGYRVIALAGKSIPGLTWIKAQRLKREQAESGLQFLGLIIFENKLKAGTTPAISTLRQAHLAIRMVTGDNPRTAISVARESGLIGVAGHVFIPTFIRGSIEDPDAQLEWSSADDDKLKLDSYSLRPFLVDENVNQDLNIEYQDYHLAVTGDVFRWMMDFAPLETLERMLVKSQIFSRMSPDQKCELVERLQQLGYTVGFCGDGANDCGALKAADVGLSLSEAEASVAAPFTSNTPDIGCFIEVLKEGRSALVTSFSCFKYMALYSLIQFTSITLLYSFASSLGDFQFLAIDLAIILPIAVTMGRTLPYPSIHPKRPTANLVSKKVLTSIIGQTLICSAIQFFIFFDVRKQSWYEPPEVNLDKLETRNYENSAVFIVSCFQYVLVALVFSVGPPYRQPLYTNILFLITLVVLFACAIIILFLPSGAVFDILELMEFPWSYHLKILGVVIVNVIASLTFEKYAEKKVAKYVGSLLRSWRHWRRGDYSKPSKAYKHVEGNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8H8</accession>
    <name>I4Y8H8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959758.1">
        <property type="nucleotide sequence ID" value="XM_006959696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8H8"/>
    <dbReference type="GeneID" id="18475678"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70023"/>
    <dbReference type="HOGENOM" id="CLU_2361345_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8H8"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="96" mass="10157" checksum="4BBD7DB9371C085A" modified="2012-09-05" version="1">MVNTFQIASIAAIATTAFAYTSEKSIVAQRTRTSRNPLEKNKAFISTGDIVSQLSLNCNNIALGGNILIEDQCKNTPACCEDVSGSTLSCSPLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J1</accession>
    <name>I4Y8J1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959771.1">
        <property type="nucleotide sequence ID" value="XM_006959709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J1"/>
    <dbReference type="FunCoup" id="I4Y8J1">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="GeneID" id="18474327"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61089"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8J1"/>
    <dbReference type="OMA" id="AYLWRPS"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697824" evidence="9">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="218"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="554" mass="62845" checksum="94F85DFBFB6CDEA2" modified="2012-09-05" version="1">MNGLNTFISLFILLSVVFGYTVPISDLDDFRQACSGIWNSKDAGISVYFDQSSHGQAALGIWEWSDLNALGKYPDNADPTVIAKSYVCTTSALQSNLCQEKDLGKFIVDNSQIKEGKKSSIWTTAARFNEMQVGSSTTISDGDAEETIGGIEKREVYKVNNGPFHYDVSRPGYYCVGSIPITVSGVNAVDDKNIHASFNGVVTFHDTKRSELPASDIPKLTFYLVMFFVYIFTGIVWSYMCYQHRGQLLMVQHFISALIVFLVVEMILNWGYYKYLDKHSYTGVSTFLLCLCAVFAALRSAYSLGLVLSVSLGWAVVRQTLEKPLIKKIATLVAAHVIFGVVNAIGTVIISFEDASIISLIFVIIPLAVTQSVGLLWTFYALQHTIKHLEAKHQQFKLRMYKNVYRILIAAQLIIIFFFGFATFTFSSRLDENFEPNNWKSRWFLIDGWSTILYYIVFVSLAFLWKPSSHHSRLALSEEVPVNEEDVEEYEIAERGYNHQAQNDQGYANVDQEDYHTEETVFAIDDEEEDDHHKKSDEYERQARERQELLGKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8P8</accession>
    <name>I4Y8P8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_20827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959597.1">
        <property type="nucleotide sequence ID" value="XM_006959535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8P8"/>
    <dbReference type="STRING" id="671144.I4Y8P8"/>
    <dbReference type="GeneID" id="18470859"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20827"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y8P8"/>
    <dbReference type="OMA" id="YANVRTN"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="731"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="764" mass="85108" checksum="26E2C041577CA8D7" modified="2012-09-05" version="1">MYNNEALTSPAPIAGYTPDLDTSHYGAPPEERIRRRGKTKKKVALTDGNLVVDLPIPSTLDKVIMRRDLEDMSKVRYTAVTCDPDHFEKEQFTLRQSLGNRRTELAICITMYNEDEVLFCRTLYGVMKNISHLCSRKNSSTWGIDAWTKVVVVIVADGRTKVHPRVLDCLASLGVYQEGVAKGAVNDKNVEAHLFEYTTSLALGPDLKFKGPEKRIVPTQIIFCLKEKNAKKINSHRWFFNGICPVLQPNICVLLDVGTRPHPKSIYHLWKAFDKNSNVGGACGEIRADTGKHGRALLNPIVASQNFEYKMSNILDKPTESIFGYISVLPGAFSAYRYVALKNDDNFGLGPLHSYFKGETIHMSENESVFTRNMMLAEDRILCFELCAKRKEAWTLKYVKSAVGVTDVPDRVPELISQRRRWLNGSFFAAIYALTHTGQILNSGHSKMRKSWLLIETFYAAINLFFSWFALGNFYCFFVVLTRALEDPSFGIPGIKFFNLVAQAVYGAMIIACFTFSMGNRPAGASFKYTAVMCVFAVLSIYMVVAAIICTVHVAQQSEHNAMYAQMLISLIATYGLWVAASLISLDPWHLFTSFPQYLLLAASYINVLTTFAFSNLHDLTWGTKGDNVPEQNTGKFKTSKDGLVEVEMYDNKPDLDGQYADALHKLRTKMPIPQAPPSAADRERAAADYLASFRSNVLLCWILCNGALIIAVLVGTGGDGAFGDNGNKKVQAYMLIILAFVAITSAIKFLGCATYMIASLFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T2</accession>
    <name>I4Y8T2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959631.1">
        <property type="nucleotide sequence ID" value="XM_006959569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T2"/>
    <dbReference type="FunCoup" id="I4Y8T2">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T2"/>
    <dbReference type="GeneID" id="18475662"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69928"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100683_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8T2"/>
    <dbReference type="OMA" id="CSQFFVG"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="165" mass="18469" checksum="607088C4D161A2A2" modified="2012-09-05" version="1">MNQFTRRLFSSTSTRAVTRPISRPDPLKNASKFTLEDGSEFIVRPPPSSAEAYVDANSVVSPLLNNNTPRVDASNAPSLHSRKKTLNFNLSEAEINEIRNLRSEGHSGSSLAKRFNCSSAFVAMVAPATKSERQSQKLAQQAQKDAWGFNKKLSRAERQKRKEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U6</accession>
    <name>I4Y8U6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_20842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959644.1">
        <property type="nucleotide sequence ID" value="XM_006959582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U6"/>
    <dbReference type="STRING" id="671144.I4Y8U6"/>
    <dbReference type="GeneID" id="18470860"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20842"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y8U6"/>
    <dbReference type="OMA" id="GCAGQEY"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="8843" checksum="1BB3C09279C4ADFB" modified="2012-09-05" version="1" fragment="single">GVKNKGCSGMSYHLEYVDKPARFDEVVEQDGVKVLVDSKALFSIIGSTMDWVDDRLSSKFVFNNPNVTETCGCGESMRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-11-27" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8V8</accession>
    <name>I4Y8V8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959656.1">
        <property type="nucleotide sequence ID" value="XM_006959594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8V8"/>
    <dbReference type="GeneID" id="18471680"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33436"/>
    <dbReference type="HOGENOM" id="CLU_488846_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8V8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="296"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="558" mass="63778" checksum="CC4F42FEC8F84924" modified="2012-09-05" version="1" fragment="single">MGSDLHLFLEKLRQSSNAWSLFACTGDGNIKSVDEGENNVRDCFRYLDPTSTQFAIIKLTRFTMEDILLVRLYGENTNNIQRSGFDDVLNNNSNYITSTEDIRVTSPRELQEFVESHLPYSTNELCVDNALRKLSSLHMNDIPHIDLVNGMVALTKNNEIVYREPQDVQVGDRILSHRPQDNCCYWQKVFAFEHIHLQAEDLIHVANLEAGESDMSKDYGITFTTPRYERVPCVTETNDKYFKSYTMETLEDIVVDKCIFQYRSPGGISSTNDIPEDLSNYLGLKTFEKKIAFLELVGMFIGDGHINLSLSYINFKHYKAEDTVYLTNIGKCLGLHYTTTSDLSETFPPNTFCKLRSFRIYTPQYVSYFQHQFNRPRDGRPSRSEVIKDIPTYLINTNRTYCQALLKGLHQADGQVYQNKIYGSEKVPFKVYVTAILAGFSPRNVLQSEEGPTEVMGLPGTATRDLYGTSWLDKKVVYTYRSQFVEDKMVSESTLGLRGIRLYLNQPNVYVSTLNRVIGSNSVEKVSTIERPVLLGCDTKNLHDEESQGYVIDMKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8W0</accession>
    <name>I4Y8W0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959658.1">
        <property type="nucleotide sequence ID" value="XM_006959596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8W0"/>
    <dbReference type="GeneID" id="18471112"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29725"/>
    <dbReference type="HOGENOM" id="CLU_839932_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8W0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="331" mass="36838" checksum="6BCC83D7F2B84E30" modified="2012-09-05" version="1">MDSNNDIIQQPDTSNPDPQTYKNQVYKMEDMKSPGDYVLKPGLRGLGMVRVAKNISQKTTVDRIRESGKPYRKLPNIGSNVRGASLIITLIGVVFSCFVSIVSATDNTSPFPVKVLGNSKNYFQAQDTSSSHYGAKSFSDPWFLEENPERLDLSKTLTGLVKFTRNQTTDKRQVQEPATEIDGYVWPPESGYIDPQDSEAMLNRIWGNDRVWVDPSAKWSWTWGTVTFTIENTNMDTDGCDGGLVITGTQLWDYLWRLHTGGATQGLNCAVSYIHPNIGTTLRASGTTLPSYSEACDGMDIELEGPPQVETPPLYGWINHPPGSWGYHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y997</accession>
    <name>I4Y997_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_65211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959334.1">
        <property type="nucleotide sequence ID" value="XM_006959272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y997"/>
    <dbReference type="FunCoup" id="I4Y997">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y997"/>
    <dbReference type="GeneID" id="18474999"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65211"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y997"/>
    <dbReference type="OMA" id="HGVHLCD"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="58"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="398" mass="44876" checksum="A95E43DEBDF15BA1" modified="2012-09-05" version="1">MTIYIYPLIHSLEADKLEYIERAAVHVDKNGTITQVERLESDKVYNDEEIISAQENEFLIPGFVDTHAHAPQFANIGYGFNLELLDWLHEVTFPTEANYEDVEMAQSDFSRVVAATLSVGTTTCSYYSSLHSEATKILATACHNLGQRALVGKVNMDQNCPEYYRDQSAEISFEQTKEYVDYVKHTLKSSLVHPVITPRFAICCSPELLSQLGDYIKNENLHMQTHLSENKGEIDFTLKLYPNDETYTHIYANRGLLTDKTILAHCCHLSDIEIDLIKKHNSGISHCPTSNFHLRSGITDVDKLINGGLKKIGLGSDCSAGYEMGILQTLRTASTASKALAMVHEKDTYLRVDRLFYLATLGGARVLDLDKQIGNFLKSFQFCQAVRLISVRETQKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H4</accession>
    <name>I4Y9H4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_20332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959317.1">
        <property type="nucleotide sequence ID" value="XM_006959255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H4"/>
    <dbReference type="STRING" id="671144.I4Y9H4"/>
    <dbReference type="GeneID" id="18470834"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20332"/>
    <dbReference type="HOGENOM" id="CLU_2741990_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9H4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="71" mass="8146" checksum="D9C6C8DA3F02D097" modified="2012-09-05" version="1">MFISKRNCRAALANLYKEGAVVTGKDFEIKHGEMSVSNPEVIKVIQSSILTGYFKTQCSWKWYYHLSSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M5</accession>
    <name>I4Y9M5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_20133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959177.1">
        <property type="nucleotide sequence ID" value="XM_006959115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M5"/>
    <dbReference type="FunCoup" id="I4Y9M5">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9M5"/>
    <dbReference type="GeneID" id="18470823"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20133"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9M5"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="16">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="464" mass="50563" checksum="A166F3EB3047C37F" modified="2012-09-05" version="1">MISVSAPGKVLLAGGYLVLDPAYSGVVVSTDARFYSLVKPTNGTTTTVNSPQFGSSWEYNSAMEQLNECPLSHLNHYSGPINDFVQLALTEVSKLISKRGITPKGLSITISGDNDFYSQRAYLNSCNLDATVENLKKVPKLNSDLKQISKTGLGSSAALITSLVGALLAFYGLISRDINQNDLKLVHNLAQYIHCRAQGKVGSGFDVSAATFGSQVYSRFDPEIIKDVMDSPTTGEIVDAVISKEWDNNVEKVGLPYGISIQLADIEHGSHTPSLVKKVHAWKAAKPDEAKELYAALNNSNQGLVKVLKALNESHKTKREAYEHALDTLSTLIPQKWQENIPANDVIAQFDELRMVLKSIRKLFRELSDKAGVPIEPEEQTRLLDACSKIEGVIGGGVPGAGGYDAIYILTISRMANQSHAQTQVHKTWLEWTELSVSPLVCGEGFEGLRLENAEEISRAMGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA51</accession>
    <name>I4YA51_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959105.1">
        <property type="nucleotide sequence ID" value="XM_006959043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA51"/>
    <dbReference type="STRING" id="671144.I4YA51"/>
    <dbReference type="GeneID" id="18474127"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60730"/>
    <dbReference type="eggNOG" id="ENOG502S0EB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060402_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA51"/>
    <dbReference type="OMA" id="YQIKHAV"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051211">
        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phosphatidylglycerol lysyltransferase C-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="36708" checksum="F137F68A1AF30BF0" modified="2012-09-05" version="1">MTRNIEKDKLAELIATNEKYSPATSWLEERYSLFIKNGNVQGYIQLDGYQFYWGDPIVINGEPIEFIRHTIDFAKENSCTPVFCEISEDLEALLENDEFKFSCLSCTHEDIINPTEANLDVKDVQQNVRRSQRAGVEVYELSGDPTDEQRDAINEGVEQWKQGRKGDQIATASMDPFLDSVHRRFFIAHIENKIVGVLILSLLKDQGYQIKNCTAFPDSPKGTSERLIVECLETLKKEDAHHVSFGISASDHMEPVHNLKGMRVSWLSGTYKSILKSTGIFRRADFRSKFNVKHEPLYICYPKHEFGMDGIQALMKTLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA54</accession>
    <name>I4YA54_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959108.1">
        <property type="nucleotide sequence ID" value="XM_006959046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA54"/>
    <dbReference type="FunCoup" id="I4YA54">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA54"/>
    <dbReference type="GeneID" id="18474128"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60732"/>
    <dbReference type="eggNOG" id="KOG1638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065395_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA54"/>
    <dbReference type="OMA" id="PEEWYTD"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="102"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="244" mass="27715" checksum="45C0CCAC3FD6572E" modified="2012-09-05" version="1">MFYYEICKITLKTFWFLGPLAVFYDAPFGRFADVTSRFSLGGRLTWFIMEIISPISFIIGFLSEGRQKSLFQLAIAGAFLVHYVNRAIIYPYLNPSKSLSHVLVLLSAGCFNTANGSIQGKYLADTSINKISLVGCVLFIAGLAGNVYHDRLLFRLKRVSNGGYIIPKGALFDYVSYPNYFCEWIEWLGYVLLCQSNTLNDAPVVFLIALVATMSPRAYKGHLWYKKKFKEYPQSRKIVIPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA67</accession>
    <name>I4YA67_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_57910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959120.1">
        <property type="nucleotide sequence ID" value="XM_006959058.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YA67">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="18472963"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57910"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <sequence length="1489" mass="166410" checksum="5C852865A67B75F7" modified="2012-09-05" version="1">MPTKQSIQPLRIEEYNWDSENNVNVEDSKQVFYDLSRRLSGESKQQQTPADARRPSLGISEATVNEENEEVSEEKDFDLKTFIEGDRKRYTEAGKTHKPHLGLTWKDLTVKGAGSGSTFVKTFPEAIVSTFGPDAYYFITGYIPQLKIFGKKPPIRNLVNSFTGTLHGREMMLVLGRPGSGCTTFLKALANKREDFVSVDGHVSYGGLSSEEVKKKYRGEVVINTEEDIHFPTLTVAQTLAFAIREKVPRIRPPGMKRSEFVNYILEALLKIFGIEHTANTIVGNDVVRGVSGGERKRVSIAETLISRASVMCWDNSTRGLDASTAVDYVRSLRIITDITGGTSIATLYQAGEGIYELFDKVCVIDEGRCIFYGPANEACAYFESIGFYKPPRQTSADFLTGITDIHERTIKEGWESLAPRTPEELERAYRNSHYYQRAVASADESFDAEKDQLDDFKKSVREDKKRRMAKSSPYTVSYTEQIYYCFIRQIQLQLGQLDGHYTKLGTILICSFVVASLFYGEAQSSGGAFGRGGVLFFSILFIGWLQLPEIWDAVNGRVIIQRHKEFAYYRPSAVVFARVLCDIPLLFVFVSLMAIIVYFLASLQYEAGKFWIYYLFVYSSAFALTQFYRAVSALSPTFNEGLRFSVAAFNIAVVFVGYVIPRMDMPSWFKWISYINPLPFAFEAVMANEFHGMTLTCDESSIVPLGAPGSEEQYQTCAFQGSVPGSLTISGDDYIQTAFGYSYSHVWPNFGYIMAYTVGYIAATAILNELFDFSGNGGGVTVFAKTEKGKAKAKETEKALTGDIESGITTNSVEEKGAAIDIKPGAIKPSEADFTFKNVTYTVPTATGDKRLLDNITGYVRPGTITALMGASGAGKTTLLNTLSQRMTMGVVTGDMLIDGKPLELNSFQRGTGYVQQGDLHDPYATVRESVEFSAILRQPRETPRAEVLEYVDQVLELLELKELEDAIIGSPEAGLGVEQRKRVTIAVELAAKPDVLLFLDEPTSGLDSQSAYSIGRFMNKLADAGQAILCTIHQPSSLLFTEFFDRLLLLAPGGKVVYQGPVGDNGSAIVDYFKRIGARECQPHENVAEYAIETIAYGRDAKGNKVSFSDLYRDSEEATNVLKEVDRINAEKSQKPKELNKMMTRTYSQPLAVQCKLLSERLLKNYWRDSSYGYGKLFTTVIIAIFNGFTFFKVGTTQTDLQSRMFSIFLMILLPPAIINALVPKYFTMYGLYNTREGLSKTYSWFAFVTSFIIAEMPYALLKAVVYWIISYWPVGFTHDGNDIRTGSDAALTFMLTLFFFVFQALWSIWLCTSAPTPQFVFNTMTFHLVILNLVNGIIIQYDAIPVIWRYTIYYINPITYFLGGMIGATTGNVNINCNQRELATFDPPLGQSCESYAGVYAENAPGYLLNGDATSACQYCPMSDSSGFLESIHVFQGSGWPWGYFGIFSLYIFSNLFLAYALYYVTKVLKFSPTTFMKNLFKKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAB9</accession>
    <name>I4YAB9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006959108.1"/>
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        <property type="interactions" value="87"/>
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    <dbReference type="GeneID" id="18474157"/>
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    <dbReference type="eggNOG" id="KOG0065">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCG_PDR_domain2"/>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="621"/>
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    </feature>
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        <location>
            <begin position="731"/>
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    </feature>
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        <location>
            <begin position="1149"/>
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    </feature>
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            <begin position="1182"/>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1269"/>
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        <location>
            <begin position="1303"/>
            <end position="1322"/>
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    </feature>
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            <begin position="1422"/>
            <end position="1445"/>
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    </feature>
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            <begin position="124"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="811"/>
            <end position="1056"/>
        </location>
    </feature>
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        <location>
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            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="772"/>
            <end position="795"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1462" mass="163405" checksum="D3727FDD4FA8557F" modified="2012-09-05" version="1">MEDQFIDKGNNLVDIDKSKEVYRKLSKQLSRDDNESIKNTAEESSETTLNEHPSEGRFDLHGFLSNDKQQLVEAGKTSNKHLGLAWKNLRVNGAGGESTFVKTFPEAVLGTFGPDVYNFITGYFPKLDVIGKKTPIHPLIHDFTGALGNEMMLVLGKPGSGCTTFLKALANRHHEYVSVEGDLTYGGLSPQEVKEKYRGEIVMNTEEDLHYPTLTVAQTLEFAIRQKVPRIRPNGMRRSEYVKYILDALLKIFGIEHTANTVVGNDFIRGVSGGERKRVSIAETLVTRASVMCWDNSTRGLDATTAVDYVRSLRIITDITGGTSIATLYQAGEGIYELFDKVCVIDDGRCIYYGPANEACSYFESIGFYKPPRQTSADFLTSVTDIYERTIKPGWESRAPRTPEELEKVYKDSQYYQAAVASTDQAFNAENNHLGDFKTSVREDKKRRMAKTSPYTVSFIEQIYYCLVREIQLQRSQIAALRTKFATILFSALTISSLFYDQSGSGSVFAKGSVCFFSTVFVCWVQLSEVWNACMGREIIAKQSNEFAFYHPSAVTFATFLVDVPVIVSGILVFSIVVYFLGSLDYTAGKFFTYFCFVSFNAVTFNQLYKAVASMSSNFTSAIRYNVCLLSIAFTLVGYTIPRYNIGNWFRWISWVNPLPYNFESLLVNQFHNVNIECDPSDIVPNDVNGAEEQYQSCGIQGNRPGSLTILGDDYVDAAFDYKYSHLWNNLGYISAFLVGYLIVTAIFTEYFNHTGGKGGVTVFAKTDKGKSKAREIEKPDDIESGPPQTTKEKGNKDIEVGAINPSDADFTFKNVTYTVTTIAGEKRLLDKITGYVKPGTITALMGASGAGKTTLLNTLSQRMATGVITGDMLIDGKPLELNSFQRGTGFVLQGDLHDAFATVRESIEFSAILRQPRETPREEVLAYVDKIIDLLELQDIEDAIIGSPEAGLGVEQRKRVTIAVELAAKPDVLLFLDEPTSGLDSQSAYSIGRFLNKLADAGQAILCTIHQPSSLLFTEFFDRLLLLAPGGKVVYQGPVGDNGSAIVDYFKRIGARECKAHENVAEYAIEMIAYGRDANGQPFDFVNAYRNSPEAAELEAEVNRIINEKSEIPKEQTKAMTRTYSQPFHVQLKLLIQRMSRNYWRDSSYAYGQLFITVSIAILNGFLFFKNGTSIQNMTERSFSAFLVLLIPPFSIVSAAPKFFINYEVFKSRENLSRVYSWYSFVTSYLLCELPYAVGCGIVYWVIWYWPIAFSYTSDGDFRLGSPAALTFLMIIEAFIFTSWLAAWMCTMSPNAKFTMDIMPFIIILLFFINGIFIDYAKQPVFWEYFMYYVNPYTYLLGGLIGATASNVAIQCSSREITTFSPPSGETCLSYAGAFVGRTGGYLLNGDSTSGCQYCPMSNSSAFLDGKHIFYSTGWPWGYFGIFTLFSISSFALAYLFFYVTKVNPPNLKSFKKLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC9</accession>
    <name>I4YAC9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958919.1">
        <property type="nucleotide sequence ID" value="XM_006958857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC9"/>
    <dbReference type="FunCoup" id="I4YAC9">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAC9"/>
    <dbReference type="GeneID" id="18475575"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69369"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="InParanoid" id="I4YAC9"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="431" mass="49060" checksum="646911A0177BCEBD" modified="2012-09-05" version="1">MISALYMMNSKGEVLISRLFRPDIKRSISDIFRVQVVSNPDVRSPIITLGSTSFFHVRHNNLYIMAVTKCNALAALVFEFIYKFIKVCTSYLGNLIEESVKNNFVLIYELLDEILDFGYPQNSEIDALKMYITTEGVKSEQAIREDSSKITSQATGATSWRRADVKYRKNEAFVDVVENVNLMMSAQGNILRADVDGQILMRAYLSGMPECKFGLNDKLVLERSDRTRIVDDSALGGAVELDDCQFHQCVRLGKFDTDRTISFIPPDGEFELMRYRSTHNVNLPFKISAVVNEIGRSRVEYTIRIKANFGNKLSANTVILRIPTPLNTTEVKCNAPMGKAKYVPDENHIVWKIPRMQGQTETTLTANAELTSTTTRQAWSRPPINVDFQVLMYTSSGLSVRFLKVFEKSNYQSVKWVRYLTKSQGSYQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAD0</accession>
    <name>I4YAD0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_54773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958920.1">
        <property type="nucleotide sequence ID" value="XM_006958858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAD0"/>
    <dbReference type="GeneID" id="18472692"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54773"/>
    <dbReference type="HOGENOM" id="CLU_797416_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAD0"/>
    <dbReference type="OrthoDB" id="10401650at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="39411" checksum="AA2F8BB0618F490A" modified="2012-09-05" version="1">MNNDNNNLNRIDRNPLEDQFSAIHQSKVLLPSPLSQSHTNEIPNLDLEVQESDDDIVEYDNDNDNDIDSLSTSNLPLKKGRKLGAKYSLIPDGAQNIDINMRKRKRQAPLPFNSQVNNAIASSSKAPVRTRAPKADPYNPQVPPPDFAKPDYKVIEQLFEPFIKKQFELQAQGQTPPPVRFPVNKRPDYIVSSAPRIPQNYIVPVPLDTYTKADYKTRKWSEHTKEIRSISGSKLRLKTWLGSEESEYSKRPPPPVNTTKSASNQGEDPSTAINPANIMTPSGVPLSKLDKRTREYKTIMAQHKAQLEQKRLDEERQRLEAKAAFDGMLETNKSEDDPSRMSINNIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAE7</accession>
    <name>I4YAE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_57797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958933.1">
        <property type="nucleotide sequence ID" value="XM_006958871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAE7"/>
    <dbReference type="FunCoup" id="I4YAE7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAE7"/>
    <dbReference type="GeneID" id="18472954"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57797"/>
    <dbReference type="eggNOG" id="KOG2904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_0_2_1"/>
    <dbReference type="InParanoid" id="I4YAE7"/>
    <dbReference type="OMA" id="TFHELIN"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="31582" checksum="1C6B2792517F0539" modified="2012-09-05" version="1">MRVTYLRNYMRRISPFDKLSARLGLEDAHNELRWIKQSSSNPREVDRMIEERVKGKPLQYILGDQPFLDTTIKVKPPVLIPRPETEYWTNELIRRHKDKTNLRIIDLCTGSGCIAINLAKELRNSTVRAYDKSDDACELTKENAKLNLTVDQLSRFEVIKRDIMTHQFDDKFDILTMNPPYITKTDYQALDKSVREWEDVDALLAKSNDAGIEFYMRVIEQLLRSNLKGEIWFEVGYNQADLVSKLVDNCSIERIKDPFGDFDRAIILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAK1</accession>
    <name>I4YAK1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958982.1">
        <property type="nucleotide sequence ID" value="XM_006958920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAK1"/>
    <dbReference type="FunCoup" id="I4YAK1">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAK1"/>
    <dbReference type="GeneID" id="18474090"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60673"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_1"/>
    <dbReference type="InParanoid" id="I4YAK1"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="223"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="504" mass="56309" checksum="BDE79C5110FAFC50" modified="2012-09-05" version="1">MSSIYQPSLADVRSLILEQKKGNCVPVYTSIQADLLTPVIAYLKISQNSKYNFLLESVAANERSRYSFIGASPLKVIKSGPNEEITGDPLPALEAELEKYKYVKVDGLDTFTGGAVGYVAYDCVHHFEPKTKRELKDPLGIPESMFMICDTILVFDHIFQKVQVVSHVNVPDNCNEVTIQARYNVAIDKIRQTIELLEDQQIPSVPHQPLIGQSSEAYSNVGKEGYEGFVTSLKEHINKGDIIQAVPSQRLARPTNLHPFNVYRHLRTVNPSPHMFYLDFDGDTPEGVRFVGASPETLCRVENNKVFNHAIAGTVKRGKSKDEDDKLGAELAKSEKDRAEHIMLVDLARNDVNRVCKPETVNVDELMKIEKFSHVIHLTSQISGQLREGKTRFDAFRSIFPAGTVSGAPKVKAMELIGELEGERRGIYAGAAGRFDFADNEMDTCIAIRTMTFKNGVAYLQAGGGIVYDSVEEDEYIETINKLMGNVKCIDQAEDYYRMLNNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAN4</accession>
    <name>I4YAN4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959012.1">
        <property type="nucleotide sequence ID" value="XM_006958950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAN4"/>
    <dbReference type="FunCoup" id="I4YAN4">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAN4"/>
    <dbReference type="GeneID" id="18471601"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32991"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049046_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAN4"/>
    <dbReference type="OMA" id="GDCEVNQ"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="34620" checksum="507606E864EE36CA" modified="2012-09-05" version="1">MSSANWHWKQLDCSKFAKEYFKEKLVGLKVNDELTIEELKECDGDVTLGQRKSKLVTIYDLKIVVEWSVGEQRGRTHVPEVSHEAIDGLDEYVFETTLIKGQADGQFDHIRKEVIPQTLKPIFDQFPVDLREKYGAHVQISQSNTPTPSPAPEAAPAVKKTEKVEVPQQKVSQKGSLNTSTVRLEERYQISADEFFDVLTNKQRVPMWTRAPAEIEPKVGANVVLFGGGVKGKVTDVVPGKKITMDWSLTGGKWPEGHNASLTISLNQGDDSTTAEFILNGVPIGLEEDVQPSLEQYYIKPLKLLFGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAN5</accession>
    <name>I4YAN5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959013.1">
        <property type="nucleotide sequence ID" value="XM_006958951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAN5"/>
    <dbReference type="FunCoup" id="I4YAN5">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAN5"/>
    <dbReference type="GeneID" id="18474097"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60685"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002074_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAN5"/>
    <dbReference type="OMA" id="QNQTGHT"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF28">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="952"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="140718" checksum="50EAD1E5FF232D72" modified="2012-09-05" version="1">MKTFFRSFQHQFRSIVAQGPSAASGSSYSAGGAGAGFHPGRNFYQGYHGYGRAFTQANNNNNPDDEDGRSPSKAYLSRRQSVSNSSRSEVVKAIRDQRRRINTVAKSEKNHTGRPRSNSTASIDNGKSNVEELSDEVESPDKPPPQASHNTQLGNKESDHGNELIARISAAKDSNDFQAVKRIVHSVYTITDPSVELWDTALEALCVTRPDSFTVEDAVSFYNDMIARDLKPTAKTYSNLITILCLRDNYVQKSLQSVNTRKVWDPSLESKAQELESEQNFRIAMSIFNLAIRLNVLPTDVYTYNWLLMSCKFHKDVDSAINVFSVLESLPQVKAQHATYSVMIDLYGSVGDLEGATVIFEDYVNAAKKKMIDSDPAFATLPANKATTVYNSMITANFNCNEALGGVELFQQILEAPMKLRPDTVAAVIEGFVRNGDVSSALEWLKRTAAASAEGSQVPHPPVSSFYFVITSLLRESKIDEAQSVFELLKECQNKFTMEPTGAELSTFSENVIGSLIKNIENVEQVVALASEIFRHQMIEKSSKGVFYPPINDLIYIASVSGRFDLAMGLYIQWAQAGKIQFIDQGLYAERNIWHKFVVTATETLVNTPGISLQQTFDAYRIAYENNVICSFKTLISIIQKVDQARKDCEGDFKLINLTLEQWKLYTNVFLQLAKSQVNLEDSNRSVPLTSATAVDFVSDIRNTFGQNSGDIAKVLHVNDLGFVLSKLIDYDFATEQLARIGYRFNGMECYTSGYVPLDRVNSDQSAPMGYPSFDSSDASSEQTPPTTPETTEANFTIDEGLSEMISRHDYRKNLGVSPEECYAVLMDGITNGLTGNVSSLANLANALGRKSEISKAKKVYTHAYDVIQNLSSLEERSMAWFKLEDAMISGLGHGGDIEGATQHRLRIIQAGGAPSADAYAACINNVKETTDDVTFAQELWDESRSLGVKGNTFLFNSIISKLSKARKAHAALEILDLMIAERVRPSSVTYGAIINACTRIGDEASAVTFFNKMVQQNKFQLRVPPFNTMIQFYTHTKPNRERALYYYGEMLSAKVAPSAHTYKLLLDAYGSIAPVDKDSLNKVFETIVNDPRAAVSGTHWASLIHSAGYVEKDVEAAVKIFESIETHPSNRNKVLPDAIVYEALLNVFVENQRQDLIPKLLDSIKASKVHQTAYISNLLIRGYAQSGDIARSREVFESMVDPPMGAAASGNHAGDSQAINVVYREPSTWSEMIKAELEAKSTENAQKLIARMEERMYPLAVTSKIASLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAN8</accession>
    <name>I4YAN8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_29232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959016.1">
        <property type="nucleotide sequence ID" value="XM_006958954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAN8"/>
    <dbReference type="FunCoup" id="I4YAN8">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAN8"/>
    <dbReference type="GeneID" id="18471091"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29232"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAN8"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="15296" checksum="FFA47F746A3C31E1" modified="2012-09-05" version="1">MQDPTGAITLRTRKFTANPLLQRRQFVLDVLHPTRPNVSKQELRENLAQMYKAQVEAVAVFGFRTHFGGGKSTGFGLVYDSADAAKQFEPKYRLVRFGLAEKVTKPSRKLRKERKNKSKKVRGTAKSKASSDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT4</accession>
    <name>I4YAT4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_69236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958760.1">
        <property type="nucleotide sequence ID" value="XM_006958698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT4"/>
    <dbReference type="FunCoup" id="I4YAT4">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAT4"/>
    <dbReference type="GeneID" id="18475552"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69236"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="InParanoid" id="I4YAT4"/>
    <dbReference type="OMA" id="QAPRYDN"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="124"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="11">
        <location>
            <begin position="329"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="470" mass="53310" checksum="B8AB1F20A3C49878" modified="2012-09-05" version="1">MRVRFAPSPTGNLHIGGLRTALFNYLIARKAGGSFILRIEDTDRKRYQPGAVDTLIRSLKWSGIQYDEGPGIPGSFGPYIQSERLNLYRSAIDQLLEAGQAYRDYSQPGEPVKLLNGRDQDLYKTHVVRLKIPEKDTTFKDTVYGEITIPAPRPPGMGYTNDPILLKSDGFPTYHLANVVDDSHMQISHVLRGEEWLSSMPTHLAIYKALEKPTPEFAHLPLLVNPDGTKLSKRSGDVSVEDYITKGWEPEAFVNYTALMGWNALKTSNSSNPSEYMTMEDLIRRFDLNDVPHKRASMFGGKLQFLNKQHLGRKVEKGDAELIDRFRTLLEKHLFVDGFQYDNEYLGEVLLLIRDRISNLNEAVLMGDYFFIEPDYMSDDAKNAYGSTSVEKIDIVLKSVYEILKNEEDWQVATLNSHLKQQQKSLGLKTNEFMMPLRWALTGKKMGPSVGSTMHLLGKATTVNRLLNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD1</accession>
    <name>I4YBD1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_69137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958626.1">
        <property type="nucleotide sequence ID" value="XM_006958564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD1"/>
    <dbReference type="FunCoup" id="I4YBD1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBD1"/>
    <dbReference type="GeneID" id="18475532"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69137"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033744_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBD1"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="434" mass="49480" checksum="2B1C2003B0436803" modified="2012-09-05" version="1" fragment="single">MSKFRESLRILTYVGVPESVINWKPRLPSRNWCIFLGITGSTTALYAYDRRETKRIMQEYKDRVIHLSQEPIGGPSQLPRRVHVYAALYPEYDEPSAAKFFKFYIKPILNAAAMDYIVEKGHRHGALATTIRERIQAERRETMGLEPPSMPPKAVESQRDREGGVVLIGRHTVKEYLAGLAQGWKSGVISRDLLAELSKVVPSLPKAGEEDTLKEYAELETVIPEIDIPVTGASTGVAKYLTSAPAVIPPQPPVLLVPFVELVGFSKVPEMLMGFFNHRAKARLGGEAAMKLINPNLQKVEPPYAEDDEEGVSYDEPWKQPQVLEFKPQGGTLCGFDVDSEMKIKKTFEDVPKGVARRRKEYYDNLIEKLKKTREQASRELKENERKEKSEEELQQERIAKEKAFREEYEGWALARKNSKVRYEPWMNGLHVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ9</accession>
    <name>I4YBJ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GfaA</name>
        <name evidence="13" type="ORF">WALSEDRAFT_32788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958689.1">
        <property type="nucleotide sequence ID" value="XM_006958627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ9"/>
    <dbReference type="FunCoup" id="I4YBJ9">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBJ9"/>
    <dbReference type="GeneID" id="18471558"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32788"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_0_1"/>
    <dbReference type="InParanoid" id="I4YBJ9"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="367"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="538"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="688" mass="76812" checksum="C552527711A08B5B" modified="2012-09-05" version="1">MCGIFAYCSHNVSKDRKYIIDCLLNGLSRLEYRGYDSAGIAVDGEDDKDTYIFKQVGKVKELRSHIDKASVDFEKQFSSQASMGHTRWATHGEPSPINCHPHRSDTTNEFSVVHNGIITNYKELRLVLEKKGYKFETDTDTEAVAKLAKFIFDSNPKISDFPTLVKSVCKELEGAFAFVFKSIHFPNQLVVARRGSPVLIGVKTDQKLKTDFVDVEIPSEDTIPAAFEDSPGAGLMNNSPNPQLRRSQSRAFLANGSSPEPIEYFIASDASAIVEHTKRVLYLEDDDIAHIQGGELHIHRLNRANDNTPSVRSIETLEIEIAEIMKGSFDHFMQKEIYEQPESVINTMRGRINFDTRQITLGGLKQYLTTIRRCRRIVFVACGTSYHSCLAVRQVFEELTEIPVSVELASDFLDRRTPIFRDDVCVFLSQSGETADTILALRYSMERGALCLGVVNTVGSTISRETHCGIHINAGPEIGVASTKAYTSQYIALLMMAVQLSEDRLSKLERRNQLIDGLHDLPEQIKKVLQSDETLTKLAAGMNDQRSLLLMGRGYQYSTCLEGALKIKEISYMHSEGILAGELKHGPLALIDENMPVLLVMTQDSFYPKVQSALMQITARKGVPIIICNEGDEGLVNNYKTIEVPKTVDALQGLLNVIPLQLLSYHLAIGRGYDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBK6</accession>
    <name>I4YBK6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Man1/Src1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958696.1">
        <property type="nucleotide sequence ID" value="XM_006958634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBK6"/>
    <dbReference type="STRING" id="671144.I4YBK6"/>
    <dbReference type="GeneID" id="18474012"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60539"/>
    <dbReference type="eggNOG" id="ENOG502QVG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065015_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBK6"/>
    <dbReference type="OMA" id="EESMIAM"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="41374" checksum="664B3E029679515B" modified="2012-09-05" version="1">MAGEAFIILLRVTFLTVAIYSILKYKSLSSELGYCDSSSLSNRILDQRVKEYDELANSPDEADAFYSFLPIPMECTPCPQYAICQDGHLRECEAEFLLTDSLLSHIPFSSFFDGIPYFGSVAFPPRCEPDSEKRALAADVGVHVLSTLEKHKGNVICGGIKRRKGLSDQVAFGLKESDVHAFISALKDKSISQTEFDEIWALALKDLADNEELDRLVQENGDSLIIARNAQIGFSCKIRMKLGSIIKKWRLEFFTLIALFFGYTMALSKIRRSSADKKRVKQLVHLTIEQVRERAYRHMEDTSISPFVIPEQVRDEELADVHSSTERQRLWSRVRKIVESNANIQVKQLELEGEITDVFEWRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC19</accession>
    <name>I4YC19_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_64459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958539.1">
        <property type="nucleotide sequence ID" value="XM_006958477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC19"/>
    <dbReference type="FunCoup" id="I4YC19">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC19"/>
    <dbReference type="GeneID" id="18474928"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64459"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041093_1_0_1"/>
    <dbReference type="InParanoid" id="I4YC19"/>
    <dbReference type="OMA" id="GCTADIR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698772" description="L-type lectin-like domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="314" mass="35880" checksum="5E3E56DC271F5B27" modified="2012-09-05" version="1">MKLFALFGLLAGFVTAGTYKDTPGSRDVDVTTKLRTHSISAPYVDQELNNRWWDFGGSTIIDANNHIRLTQDKQSERGWLWSRLPLTVSSYQIEFEFKVGGKNNHLYGDGFAMWLTQGRNKEGEVFGSVNNFKGLGVFFDTYANSRHSYPFPRISAMLGDGETLYDNNKDGDEQSLDGCSIKFRRTEITPKARFSYLKGNYIKLELQTKKWGEWEECFTVEDIELPLHPYLGFSSITGEISDNHDIISVNTNELTKRGTNPRAQAKMNNTKKAKSKSFFRKLVNFVTYTIILALLGVVAKIFHTAYKRRQAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC81</accession>
    <name>I4YC81_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">WALSEDRAFT_60322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958270.1">
        <property type="nucleotide sequence ID" value="XM_006958208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC81"/>
    <dbReference type="FunCoup" id="I4YC81">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC81"/>
    <dbReference type="GeneID" id="18473888"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60322"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="InParanoid" id="I4YC81"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="361"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="629" mass="71483" checksum="61903A61B852AE9D" modified="2012-09-05" version="1">MGRITKKNEKGAVKNYMTRNQAIKKLQISLADFRRLCILKGIFPREPRNKKKANKGSTAPKAFYYTKDIVYLQHEPLLNSLREYKSFAKKISKAVGRGEYAQAKSIEENKKPEYRLDHIIRERYPTFQSTLNDLPDAISLIMLFSHLPANSKIPADIIENCAKLSAQWQLYVMRTKSLRKVFLSIKGVYFEAEVEGRPIRWLVPYLFTQHIPEDVDFRILMTFLELYQTLTGFVFYKLYNDINLVYPPPLDIDKDGTGAGIGAFSLRETTGALTKSGQDDVVESAKISAKDVRKQIDQIGSSGAPPADDQLEEQENNEEVDQEGLPAPEEFVEQPSKNVEASTDIGQSLNTLIENSKFESARANLFAPYTFYLSREVTRPTLEFVIRSFGGQVGWDMTTLGGGSPIPDEKDPRITHMVVDRPQLPERLKELNLKRAYIQPQWIVDSANAGRLLPTEPYAPGETLPPHMSPFEVTEDDAYVPGLEIEEADAEEDDEEEEEDEQIEEEKEEEKPKSTYPTEALLAAAQNPDDEALHDAAELEAEQLGVSHDVFEAELKKAKKSASKKKTSDTKDKEEDDMAHLMMGSKQRKLYNKVKHSQKRQTDERALLESKKKDLKKKQLKEKKKSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG9</accession>
    <name>I4YCG9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_18480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958241.1">
        <property type="nucleotide sequence ID" value="XM_006958179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG9"/>
    <dbReference type="FunCoup" id="I4YCG9">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCG9"/>
    <dbReference type="GeneID" id="18470769"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18480"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="InParanoid" id="I4YCG9"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="153" mass="15734" checksum="E771D290A9DE1F49" modified="2012-09-05" version="1">MSSDHSRDPCPYVILNDFGGAFAMGALGGTVWHGIKGARNSPRGERLPGSLAAIKARAPVLGGNFGVWGGMFSSFDCAVKGIRQKEDSWNAIISGFFTGGCLAIRGGPKAAFGGAVGCGILLGVFEGVGVLLNKAMSDMGKPQMPARMSSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCL9</accession>
    <name>I4YCL9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958395.1">
        <property type="nucleotide sequence ID" value="XM_006958333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCL9"/>
    <dbReference type="STRING" id="671144.I4YCL9"/>
    <dbReference type="GeneID" id="18471524"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32583"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="I4YCL9"/>
    <dbReference type="OMA" id="DYWKVFV"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="457"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="74891" checksum="4E0651FE693618CC" modified="2012-09-05" version="1">MSDIKQSNVDVLVIGAGPAGVIAADWLARFTKYGVKTRVIDKRSHKVFTGQADGLNPRSLEMFQSFNLMGKIGSEANPMNEVSFWAPNENHGGIERSRRIPDTIPGISRYVQSVLHQGRIERHIIDDMLEKSNGTMKIERGVLPESLEINDDLIDEDDAYPVKVGVRQLSEEESRPKLASKHGEVESGLYKSNLIKDEEDDVEFNPNVPVGDKEIINAKYVIGADGAHSWVRRQLGFKMVGEGTDFVWGVVDGVPITNFPDIRCRAAIHSNAGSLMVIPREGKIVRLYIQLNLTVDEGGHVDRSLITPKMLMEQAKAVFHPYTIDIPEIIWYTGYQIGQRLTTEYAKNNRVFIAGDACHTHSPKAGQGMNASMADTYNLCWKIGHVLSGHAPRSILDTYESERRPFAEHLIMNDAQLAKLFSGKPLSSAELNELGIDMKEFETVLEKGISFFLGTSIEYFNSAATANGKDGRLASKQELATKVPVGQRFPSFQVVSQFDGRHFHLVDTMFAEGQFTIVLFAGNMENPVHRQRLETIAQRLDSDDGVVSKHTPNNRERDSIIDIKTVHCGNRVNVEVHDFPQPTVYPPGTYNKLYVDDVSYHAGHGEAYKNYGISEEAGAVVVVRPDHFVGLVTSLDGAGFDDVETYFSNLLKTVPAGERNSAKDIKVIPQPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCQ2</accession>
    <name>I4YCQ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958055.1">
        <property type="nucleotide sequence ID" value="XM_006957993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCQ2"/>
    <dbReference type="STRING" id="671144.I4YCQ2"/>
    <dbReference type="GeneID" id="18472894"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57260"/>
    <dbReference type="HOGENOM" id="CLU_1485525_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCQ2"/>
    <dbReference type="OMA" id="RIEECTA"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="20296" checksum="60B0A55EE87A3F1E" modified="2012-09-05" version="1" fragment="single">MNRSHFLNDRLIYIPDFITQSEENSLIDTLENRITQRQWRYDGGYKHQFIGGQLTKAGKLIQSSTPDHINSIYTRIQDYTSVLPNYSELYVIQPGQGHSGSVKATTATLTLSTHLVVQTELANTPILLEPRSLLIAVDNGPPNVIPGAVDRVTSPPASLLNAEHLTKDKYKRFVISGGQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCQ3</accession>
    <name>I4YCQ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_28462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958056.1">
        <property type="nucleotide sequence ID" value="XM_006957994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCQ3"/>
    <dbReference type="FunCoup" id="I4YCQ3">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCQ3"/>
    <dbReference type="GeneID" id="18471044"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28462"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083737_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCQ3"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="180" mass="20903" checksum="D49DDE9BA6231D3F" modified="2012-09-05" version="1">MSKKLESNPRNIPAAPFVNDVVEYIGGQDAEVDSALKQFQEMAAKYRYMEISLLQKKKSLDVKIPDIKKTLAMVKHLNNNRESSNKTLFELHDTLYAEAELENTDVVYLWLGANTMLSYKIPEAIALLDNKLKLAETSYKNSNEDLEFIREQTTITDVNTARIWNFDVKRRREKREVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV1</accession>
    <name>I4YCV1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_18055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958023.1">
        <property type="nucleotide sequence ID" value="XM_006957961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV1"/>
    <dbReference type="FunCoup" id="I4YCV1">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCV1"/>
    <dbReference type="GeneID" id="18470750"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18055"/>
    <dbReference type="eggNOG" id="ENOG502QUUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_1"/>
    <dbReference type="InParanoid" id="I4YCV1"/>
    <dbReference type="OMA" id="DTWIMRR"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="873" mass="98070" checksum="CE07B6B6D68C6EF6" modified="2012-09-05" version="1">MYRTIIRNINTSKIKISLPKKPLEVHREPAKQFAINPFGYHSDQLSSDLLRNVVTTINNHPDALVLTKVGGFYEAYYDHALELSKLLSFSLGDKSYNKTRFPMSGFPAYQLQKHLRTLVVDHSLFVAINDQFFNHTTGTFDRRVTRVVTPGTLLDESSLNPNTHNFILSVIYQEPTQQVALSWSDISTGDSYAETCKPADLKSYLARLSPSEIVLDIQLTPSQSSTLQRLMGSHDATVTYAPMQESKAKRSKEYTPLENAAISLLQSRIKTSLIENTPEISPMRDLAANKLILDAQTIKGLELKSTIRDNRAAGSLLKAVRRTCTQHGHRMLERWLCEPSSEISKIRSRHDCVDLFKSRFQLRRDLRGFLKDIEDGPRLLQRIVLASSFKPSLLLSVKRVIEKSQEVVNRIQYEHKYEGLHAKSTEWSSLLELTKTLKPLIKFANKVDQVIIEDALRAKDTDELENEGEAEPEETKRSNSSDIYNDDFKRSITPRYSPRIAQLNKKLDKLYKSRDELAKMVRNDFKVTDSSQVLLRSNQKLGHYITARKNGNKDIPSAYQVVASQKSTASYSHPQWTSIKSAIIDTSEELEKAEREALTSLKDELSAQSEAFKHNNNLISQLDVLLSFAELAEEKRWTRPHMTTDRTLDIKTGRHPSVEIALQDSLNSFTPNDTYMDDKAYINAIFGPNMGGKSTYLRQNAIIVVLAQAGSFVPADKAVVGVVDRVFSRIGASDDLSGGRSTFMVEMTEAAEILSTSTPRSLVIMDEIGRGTTSVDGLSLAYAMLIHLATENKSRTLFATHFHELDDMLDGQNLPVRFLSTDLDAGPDGFAFTYTMREGVCKDSHGLIVAKLAGVPDSCIAHAEEASQKIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCY7</accession>
    <name>I4YCY7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958131.1">
        <property type="nucleotide sequence ID" value="XM_006958069.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YCY7">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCY7"/>
    <dbReference type="GeneID" id="18471482"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32400"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="InParanoid" id="I4YCY7"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="467"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="657"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="857"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1433"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1784"/>
            <end position="2151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2164" mass="244356" checksum="CBCE670CC7683C90" modified="2012-09-05" version="1">MSEPPNSPHSNNPRKDPQPIIQAQIVFLVSTITEDNLERNYSEIKSLIEQHGQDNQIYFIRRLLVSYVNQLKGIENNPTQIKLLRLELVRLGATVDQALHVRESIDNEQFDGINLDDLLKKLEIPLVESLFIVAALLDAQSQNLIEQSRFILNNWLIDQTSKQIIVGAGSFIEENNPDLNALLITLLSHDHLDISHIQSLLLALSTRLKTSLPSILAKSVVPDLKFNQSKTLAQLLVDLSSTTELRTSVELLEAAFHKFGWPSAQQQTESLDLRASELFSSLGQLGIMSNNVDISTIMSILNNYPTKPSHQLIIRGFDSPNNPPPTPNILANILLSAPPGQVDDESPLLGLVGTWVNPSLQINAIAGLLSLPNDQFSFAALPSQKIITVDYVNQSSPAIKAMAAAVQSSLWNCIDTVDIIIKLQDHGPEPINVLARELLETGCRTHGEIILLGLVQLPKPWSNYHLELITRLLALFLAGNPSHQLVFLRLWQIDRNFLLGAFKQFYQDNNMNVTRILDVAQDLKILDQVLEIKPVTFAFDLAALASRREYLNMEKWLQNGVTVHGISFFRDSLKFLDSKAKAEAIKLNTGAVNNQLNINVQTVAMFLRVLRANAEVLPLVSDDIEYYKEVRNLCLQYWPRLMNLTPHSEQEPGLSVTTFSPDLDRQVEDYYHRMYSGELRVDEVIVFLEKCKQSSNPRDHELFAAMIHTLFEEYRHYETYPAAELALTGILFGSLIQFQVIDFIPLGIAIRYVLTALQSLPNTNRFRFGVQALSQFQRRLPEWPQVCQALLAIRHLIETIPDLGFYLRLAVEHSNEVRRSQGGSALDGPDIATPTAKLSFNTVKPDALTTDETEDYSVPDEETSDRILFIVNNLAPNNFSTKSDEMKERFKAEYSRWFAHYLVLERVSIEPNNHNLYMQFLESIDESDLLRHVLRETYIKVRELLNDDNTVSNSTDRSHLKNLGSWLGGLTLAKNKPIRHRNIAFKELLLEGFDTNKLIVAIPFVCKVLEQCSNSRIFVPPNPWLMAVLKLLVELYIVADLKLNLKFEIEVLCKSLGIEIKDIEPTNLVKNRPSKDAVPLAAINQTTPGGNVLGSELERLQMAGVPNERVQAALLQQQASAAAQQQQQLQFQQQIASNGNAQQPLAPESPVLQEERTQPSIAPELIAAVPNISQYLVFDSSNPIFANNAHLQRMMHIAIDRAIKEIIAPVVERSVTIASLSTRELIVKDFAMEGDETKMQAAAHLMAQNLAGNLSLVTCKEPLRISVVSHFRHVLHQSGLSEQSVPEQTVYSAVNENLDVACKVIEKLAMQRAIIEVDDQLLEGFVSRRKHRETTNQAYWDNAVISSAHFSNSLPDLLRIKPNGLDAQQLQVYEGFNRNNYAVQQQQQQQQQPEVIESIPPGTQQRVSVDGNGNAGAINPQQSYERFNQLIVEIEKAIVASQVDSSELLPPNSELRPLVQEVSILAFQSQNFEEVSLSFAQRIVQLLYRAETNLGREVHVTILQHLCELSMKAAKEVTAWLVLSDDDRKFNVPVTLYLVKARLIHIEELDLTLSRSIVRDMRQSAIDFAATLIKESIQDQIATRSNFTHCLEALTIAAQNSKTSDAMTKLHQALKQTQPGNVATPVLNRLTKTSNDQETALRQRLALNFADWVRIYGMTQQVEKAFIPYISQLQSQGILKGEETSTLFFRICVELGVESFIKQKNDGVTNISNAFQPIDAFVKLVVLMIKYHMDHTGLNHDQAKQVYLNKIISITSLVIAQSHEDLQENFEQKPFYRLYSSLLIELWSIRQHLGVNAYKGILVTISNSLANLQPAYFPRFAHGWVSLISHRNFLPIILALENHENWIDFHRLMTALLRFVKTFTSKPQFQTSSKQLYRATQRILLLLLHDFSEYLSEYYSGLIDVIPSSCTQLRNLVLSAYPRNAQTNSLPDPFLPSIDIESMPQSQFNPTISSDYMTIIINNGIKDLVEQYTSGEAKEEIVDEIIRKITDTSAAVDYDNDDWKYNVPAINSVVLFIGVEAITHSQTDTESVKFDGGSTNTKLIMSLINRLDAEGRYLVLSAIANQLRFPSSHTYWFNRMCLKILEESSSTNENVVEILTRVLLERLLVTKPHPWGLLLTFFNVFLNPEFKRYQNKFSNLAPEFATIFDSVEKSFGRAATVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD67</accession>
    <name>I4YD67_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_28588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958205.1">
        <property type="nucleotide sequence ID" value="XM_006958143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD67"/>
    <dbReference type="GeneID" id="18471049"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28588"/>
    <dbReference type="eggNOG" id="ENOG502SBXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_869320_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD67"/>
    <dbReference type="OMA" id="KVEAHEH"/>
    <dbReference type="OrthoDB" id="2224399at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="320" mass="34417" checksum="D1334CF7367161C4" modified="2012-09-05" version="1">MLNPRPKLPHTKSTAKAFKPHISLGSVPQTPSSRPFDPRLLLGQTPTSPKLLAALGRLATAIDTAFPKVEAHPHNVWFRYVDLGLSLGFRPIDDYVPAEGEDVENLDFARLILAEVTLYNSHKLQQDPPFPFLPLTIPPPRSASQATTPAVSRSNSVSSNASGKSFVSGDGRWPAPPSLTPVSSSFGSLGGGLAGGLAAGLAGMSTLDSDKPSTPGTPGYEPPRGSVELTETSKLQNFMKTLGDPQESYSEPTPNNDVAHAPRTQVVKNWPRYAIKAQFAAPPESDFSRQMEARWLTVRISDADGFEEDPPEKEIVGVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDA6</accession>
    <name>I4YDA6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957760.1">
        <property type="nucleotide sequence ID" value="XM_006957698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDA6"/>
    <dbReference type="FunCoup" id="I4YDA6">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDA6"/>
    <dbReference type="GeneID" id="18473742"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60103"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002060_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDA6"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="621"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="839" mass="95564" checksum="6C4CFCE1C107EB06" modified="2012-09-05" version="1">MSLVNTFKSHPNVKEHQLRLHKCYKIVDDIFSYEITYNDILIATKNYIKIITVNKGVNETAYQNLSWLESPDSPICHISFSQHFNSFIFISQDGHAYYAHLDSEWKGCCIAKPPTTAVVSSFNEQFSLISIGTSDGKVLNFAIRPNNEAPIQSHTFSENSTIGAVKQLNWTHDGYALAIAYENSWSIRSIYGRILVPTSDDLLSFIPNSSQRIQKFQDRHIWGLKNIFWGTQSLEIYLLIRNADESHQLFVIPLAKSAVTTQHSPDNTRYAFLQMYDKLLVYRGADQSDLSVINPESDVWESIKIPLDYLHTQFPIKYSSISSNGKFVAVAGRNGLAHYSTTSKKWKLFNSEVDEQSFSVSGGMVWFNHILIASVITETNEYQLRLYSRDQDLSTRVVLYIENIPSRILLTSLFENALLVYTADNTIHHYLITPTNDSITLNLANIISFQGVVSNPTRVRGMSWMIPPSQRKLGDPIDDLTVATIIFLIDGKLVLLRPRRIAQDQVKYDMQVLSDGIEYYWTHLNGIGALENSLWGVDGQGIRLWLDALTLTQSEREKARNSQNSNLEIVKESVRIELDFYPLSVLMDKGILIGVDHEASLRGNLPFISYKIHTNTHLFLHHTIRFYLMRGSLKEAVIFANNYSDLVYFPHTLEILLHSVLEEEADADVSNNLLPLVIEFLDHWDCALQVVVGCARKTEMSRWSYLFDVVGAPRELFEKCLKAHQLKTASSYLLVLHHLEQLEGTDDAFKLLHKALVGGDLILSKEIIRFLHSIDPSGVYMQNIMDLIDNLKNTLPEISNNIPVNGLSQLDEEDEYNLTLQRTFSARKREGLGITLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDC3</accession>
    <name>I4YDC3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_28238</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957775.1">
        <property type="nucleotide sequence ID" value="XM_006957713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDC3"/>
    <dbReference type="FunCoup" id="I4YDC3">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDC3"/>
    <dbReference type="GeneID" id="18471031"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28238"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_11_1_1"/>
    <dbReference type="InParanoid" id="I4YDC3"/>
    <dbReference type="OMA" id="EMADQFV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="556"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="598" mass="68230" checksum="C507F9D0076E6E20" modified="2012-09-05" version="1">MDSVIRKRAEEQFRARREYSEDDDLKKVARAPVPPFSRQKQDYKINDLPNLQRTRDPSFEMYGGHVPSTTDSESNSHLYFALVEARQKTDKTRTIFWFNGGPGCSSFDALMMEVGPFNLIKNEKGELGLKEKEYGWHEYANIVFIDQPVGTGYSYAQTDSYVHELDQAADQFITFLNNFYEIFPELKNTDTYISGESYAGQYVPYFANKVIETPDLPLNLKGLMIGNGWIDPISQYPAYAQFAHAEGLIQPGTKADKEMMDLVERCEKSLNSALTREEKTGILQIYISECELIMDQITGSHRKYENGKATCLNTYDYRLRDEYPACGMNWPNELHDVTEYLRKESVTKAFNARARAESWTECNVKVSRELTAIHSTASVRLLPKILKHTKVLLFAGDKDIVCNYQGIENLVDNLEWNGGKGFSGDTPQLWSMHGNPVGEWQAERNLTYVRVYNASHMVPIDAPEPMLDLITRYMEVDLKSVKSSDNYNFESAVGDINEFGEEDSSVSWAGSHKKSGSFALLLIIIGVAVGGFLWIRRRRRQMLVHDYSQLRANTLSQEQEQGIETSDRRSNEQIESERLFDVGSDIDSDEGDSNKHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDN0</accession>
    <name>I4YDN0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957876.1">
        <property type="nucleotide sequence ID" value="XM_006957814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDN0"/>
    <dbReference type="STRING" id="671144.I4YDN0"/>
    <dbReference type="GeneID" id="18474870"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63812"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702493_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDN0"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000270">
        <property type="entry name" value="Nuclear envelope-endoplasmic reticulum network protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="194"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="44183" checksum="D38765A27B2AABC3" modified="2012-09-05" version="1">MNSLKLIDRILTAPLRRTRRRRYANTDIHLQFPEQYPNNRNSIIRANNSSWLFQFIFRLFTKNDGYSHNDSLINDDLHKEKDELDQFLNIEDKSPATKTSHGRPVKRETSQTNYQDLLTNPPKSAKKQDQQYPFAPPFNRRRTTSTDNNLLPNPLPSRNLLAVSGSGASQTTYSPSPSPPLESRSKKLSNKSTGVHLPKTLVLDLDETLIHSTSRAPQRSSNGFSLGLRSVLSGNGIAGGDGGAHMVEVVLGGRSVLYHVYKRPHLDFFLKKVASWYTLVIFTASMQEYADPVIDWIDAGRGILTKRLFRESCTQAPNGSYMKDLDIIDKDLSRVALVDNSPISYNINPANGIPISGWISDPNDEALLDLLPFLDSLRFTTDVRRVLGVRGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE42</accession>
    <name>I4YE42_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957499.1">
        <property type="nucleotide sequence ID" value="XM_006957437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE42"/>
    <dbReference type="FunCoup" id="I4YE42">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE42"/>
    <dbReference type="GeneID" id="18475367"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68236"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="InParanoid" id="I4YE42"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="294" mass="32018" checksum="50DD8919CA97EF02" modified="2012-09-05" version="1">MSGPFEQGYLPEINFQNKPGLEANMPSKPVYDRLPGGPYKAAGKLEGKVALVTGGDSGIGRSTSFLYTLEGASLVFTYLPQEERDAKDTIAIIKERKSDAKVHAISADLRKEEECIRVVEETVSTFGKLDILFNNHGTQTMIYDIKDITTEQWHDTFNTNIHPLFYLSKAALKHMKEHSGATILNNASINAYIGRPDLLDYTATKGAVVSFTRGLANQYINRGIRVNAVAPGPIQAPLRESTMEKPAQEGFSTPMGRPGESIEIATAAVFLVSNDSSFITGQTIHVNGGSFTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE61</accession>
    <name>I4YE61_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_59972</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957517.1">
        <property type="nucleotide sequence ID" value="XM_006957455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE61"/>
    <dbReference type="STRING" id="671144.I4YE61"/>
    <dbReference type="GeneID" id="18473661"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59972"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE61"/>
    <dbReference type="OMA" id="DYHNITP"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697730" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="19"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="710"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM22253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="790" mass="86266" checksum="BD80BF7982634BAD" modified="2012-09-05" version="1">MKFTTLLTLAVGLTVVNSRVVSRQEDEIDASNTRENNDPNVYPPPLANGGKAWADAFKQAEEIVSQMSIEEKAALITSQEGRCVGTSAGAERLGIPQLCMMDGPTGPRPIKGISQFPVGQAAAATWDRDLIYQRSKRMGQEFFDQGIHIALAPVSAGPIGRSPLGGRNWEGSYPDPYANGVYSYLSVLGLQDSHVAATTKHWIGYEQETFRHPYNTSQQDDVFPVLEQEPISSNIDDVTTHEVYMAPFAEAIRAGSAHIMCSYNDVNGTHACNNAYTQNHLLKTELNFQGAVVSDWGGVHHDIESATNGLDFSAPGVGFNGTMGHFWGGLADLVKDGSVPEERVTDAAIRLLTPYYWLGQDSENTPPEIVFNGNKYNLKDENGYRNVRQADTADLIREIGTESVTLLKNTGGLPLNKPERLVALGSDLASNALGPDGCGDDGTECPMGNFNGTLTMGGGSGYTIPPYITTPLEALKQRTQADGTEFSYALKNDDTTIQKIVPRSDATLVFVNNWAKEEADRHDINIVEEQASLIDAAVNSSSNVILVLHTPGVVDIEKWVNNENVTAIVESYYPGQETGSSVVPVLFGDVSPSGKLPFTWGKSLDDYPPNTVVSDAVKEPQADFTEGLLIDYKWFDKHNIEPRYEFGFGLSYTTFGFSDISVEDTYKKDDKEIQATNEPFEGFGEGKSLYDVVKAVTATVSNTGDVEGSEVAQLYVSFPGEGQPPRQLRGFEKVKKLKSGESQQVTFDLRLKDLSVWDTNKQMWVLPSGEYTFFVGSSSRDLPLHATSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED1</accession>
    <name>I4YED1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957578.1">
        <property type="nucleotide sequence ID" value="XM_006957516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED1"/>
    <dbReference type="STRING" id="671144.I4YED1"/>
    <dbReference type="GeneID" id="18473685"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60015"/>
    <dbReference type="eggNOG" id="ENOG502SYGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1612098_0_0_1"/>
    <dbReference type="InParanoid" id="I4YED1"/>
    <dbReference type="OMA" id="HIWKTHA"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19542" checksum="1F5F033D3073F6F7" modified="2012-09-05" version="1">MNFLRNISTNLRTNAVKSMRTYSTQPRISLANLINSGSKPNSQDPLTGTRALTPEEIWAQAHQQRMRTLAQEQPLSLYAGRTVVVGKYDKNSATSQVERAWKRLNGTLARNEVRRDLMLRDRYERPHQMRRRLKSERHRRRFAEYIRQKVSLVHSIRRRNEMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH4</accession>
    <name>I4YEH4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_37163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957620.1">
        <property type="nucleotide sequence ID" value="XM_006957558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH4"/>
    <dbReference type="STRING" id="671144.I4YEH4"/>
    <dbReference type="GeneID" id="18472000"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37163"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052213_3_0_1"/>
    <dbReference type="InParanoid" id="I4YEH4"/>
    <dbReference type="OMA" id="PLCVHWS"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28437" checksum="913227F6B52949DA" modified="2012-09-05" version="1">MTSDCRKLATLGLVGKLVKHTRPENFDKLVRYLSSWSGTDKFFMLIQYISKLVIWSLNKSKKADGLSTRMRSLSALVGDHRVLLRLWGLLPMLQWAESIESERKVSKLALNVERLQALSMIAYYPLEHTWYLAHHGVLPVTPSTSNKISVWSCRFWMLYTVLQLVHNWDDHSTLLKDKERDLSEEKGVNRFAIDKKLKGIVDDTIINLAYLPLTLHWSLPAGIFSNDAWVGLFGSIAAVTQFKVGYTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEM7</accession>
    <name>I4YEM7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957664.1">
        <property type="nucleotide sequence ID" value="XM_006957602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEM7"/>
    <dbReference type="FunCoup" id="I4YEM7">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEM7"/>
    <dbReference type="GeneID" id="18473716"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60063"/>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="InParanoid" id="I4YEM7"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="32"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="34298" checksum="EA47266B4DC2634D" modified="2012-09-05" version="1">MSTTLKALSKKRAASDDEADAPATKKTVQNKQRVLVLSSRGVTERYRHLMSDLQALLPHTKKDSKISSKTSLATLNELADLASCNNIMFFETKHHAQITDLYLWLAKAPNGPSVKFHLQNLHTMDELKMTGNCLKGSRGILSFGEEFDSEPWLQLLKELFTHTFGVPRTSRRVKPFFDHVLSFSYLDGKIWFRSHQIVEKDATTIKAELGNKNKSPATTLVEIGPRFVLTPIRIFEGSFGGPTVFSNPEFLPPTKLRKMEREKKAEKYSNRKDTQSESKQRKKDISNLDKGLAGELERSKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEZ8</accession>
    <name>I4YEZ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957210.1">
        <property type="nucleotide sequence ID" value="XM_006957148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEZ8"/>
    <dbReference type="GeneID" id="18473565"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59817"/>
    <dbReference type="eggNOG" id="ENOG502SCA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEZ8"/>
    <dbReference type="OMA" id="VNINCLP"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013985103" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="10769" checksum="FCAAEFBF6DC08404" modified="2012-09-05" version="1">MIAQTVFAAAIVASVSAGWESKTGSCNTGSIQCCNLSEEKEISTGKNDALISTGDIASQVGVQCDQIPAIIGVAIEDECKNTPVCCEGFDSEELIGLGCDALPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEZ9</accession>
    <name>I4YEZ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957211.1">
        <property type="nucleotide sequence ID" value="XM_006957149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEZ9"/>
    <dbReference type="GeneID" id="18475328"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68011"/>
    <dbReference type="eggNOG" id="ENOG502SCA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEZ9"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013986561" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="10812" checksum="E4D1F671BC267B5D" modified="2012-09-05" version="1">MIAQTVFAAAIVASVSAGWESKTGSCNTGSIQCCNLDEKKETSTGKNDALISTGDIASQVGVQCDQIPLLIGVAIEDECKNTPVCCEGFDDESLIGLGCDALPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF64</accession>
    <name>I4YF64_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_56792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957275.1">
        <property type="nucleotide sequence ID" value="XM_006957213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF64"/>
    <dbReference type="FunCoup" id="I4YF64">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF64"/>
    <dbReference type="GeneID" id="18472856"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56792"/>
    <dbReference type="eggNOG" id="KOG3345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053736_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF64"/>
    <dbReference type="OMA" id="NIKTGGM"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32597" checksum="081D873B30C76A95" modified="2012-09-05" version="1">MFKKRNINKSTRREKSIEESNNVDNDDDSTISDTIEEKHLIRKLKRQAAGIDSEKLVQTTSNSKKPKLDNSQSKEAHGWSASSGGIVDNTEKLKEASNPQDKLVKTSNFTGQSATIDVDKHMMSYIEEQMLKKHQQQGLPTDNLNLGITNERINNPQDELYDIAQKYTYKSRNLDDGSITNSESMLTKIPEVDLGVEAKLRNIQETEKAKQRMRDLEKHTSRKPANTDPDYTQTRFMQPSLARSRIDTTSLEPLKQEDAVNDYRQQGKASDKDHYTRFRSAMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFL3</accession>
    <name>I4YFL3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_31914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957412.1">
        <property type="nucleotide sequence ID" value="XM_006957350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFL3"/>
    <dbReference type="STRING" id="671144.I4YFL3"/>
    <dbReference type="GeneID" id="18471391"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31914"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_0_1"/>
    <dbReference type="InParanoid" id="I4YFL3"/>
    <dbReference type="OMA" id="TSIRHET"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="5">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="25087" checksum="4A920838F5812592" modified="2012-09-05" version="1">MQFFNFIFLKRNWSKDETTLNNQLGSISDDNFTLLLFPEGTTLSNESRPRSIRYTEKIGVKDFDHLLYPRVTGLLASIRALKHNSLVDIIDTTIAYPNIPKDIYGQDYYSLRSIFFNGKFPDIIHMHMNSYSLEDIPIDNDENFTKWLLSRWQEKEKRLELFERSNALDEADDYEDIPITFNKPLMHTLDAFVWFVPMIITWLIYKTIVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFQ8</accession>
    <name>I4YFQ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957454.1">
        <property type="nucleotide sequence ID" value="XM_006957392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFQ8"/>
    <dbReference type="GeneID" id="18473643"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59948"/>
    <dbReference type="HOGENOM" id="CLU_2591607_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFQ8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="9408" checksum="800493807D74C674" modified="2012-09-05" version="1">MFLEHNNNFLVDTLNSQSCNLTFTNVVFTIILRTAFDYVQAGSIVAYTKNKYGPGHYMEEPTHYCCDLKWCFCGLRQRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS4</accession>
    <name>I4YFS4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_62837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956869.1">
        <property type="nucleotide sequence ID" value="XM_006956807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS4"/>
    <dbReference type="STRING" id="671144.I4YFS4"/>
    <dbReference type="GeneID" id="18474794"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62837"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1604028_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFS4"/>
    <dbReference type="OMA" id="AINARWQ"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="166" mass="18948" checksum="F19A27C7E7486A01" modified="2012-09-05" version="1">MKQNHYDTLNISKDASQKDIKLSYRKLALQNHPDRTGKATDEQFREVQEAYSVLSDPMRKREYDLTNGSASIQLILIVTILAMIYLVYKISTFLPILLLCLLTINASKLGRSRALPLTLIILSFTSGWLFLLLWVISIGSNLDDVEWLFWGSLSPGQSNRRGWDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU9</accession>
    <name>I4YFU9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956893.1">
        <property type="nucleotide sequence ID" value="XM_006956831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU9"/>
    <dbReference type="STRING" id="671144.I4YFU9"/>
    <dbReference type="GeneID" id="18471328"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31558"/>
    <dbReference type="eggNOG" id="ENOG502R2RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007074_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFU9"/>
    <dbReference type="OMA" id="TSVWLPW"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697767" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="255"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="496"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="946" mass="103767" checksum="7F7E0DBFC5088EBD" modified="2012-09-05" version="1">MNSLRLLLISTLLYTLSLAQPQSAPFSNCQSGYQQSPDERRINISNVYTQLDKSAISTEHIAVGQNILRTILIGDLNDPLTATNSSTDRLATLLVHSRALSFELYDQPLSLCDHVLGANSSSNEPACPAPEGRIAIGVATPLPDPAKFNNHPYALTTLVNTLRLLDASDPATELACVDVPFTPYYPDGWFYELIFWIPISIAIAFFVVQSIARISTAYRKAKSTKFVRTWAGRQRLETSVIGGISGQMFSTTPGLLRFVSPSVGNIILHTQWCAVLGMIAVNWPSFAYPFFNQFVWSSLLFNVSLTTSDHVDPLATEELSIPSPFDTLLFENSTSPLYLNRDAPNNLLDNGDVSHAAGLDSLAQVIGLKKDDLFGCSVALALAIAAVLIVVSLLLWTIDSMGMLLWKRHANKGREDRSLVNRLSMTNTASDVSVLGNGNFNRHKSEQDLTLPQTNDSSTFKRFQTKYSNNNNNARSGFRRAIWEMRLGGASGGFHWKLLQGNLLRLLLLFHFPVIILSVYQLSLNNDGATKVSLAFAALALVFLGLAFPIYVLIRVSRTPTLKLYDATRTILALGPLYSVFRPGSHLFWAFFFTQNLIEGIVIGAAQASGTAQSVIILVVEAAGLLMMTVWSPWGYGAQMGLLTFLNSVARVITSALLIVLCPAVNINYVAAGWVTYVIFVIQGLVFATALVIILTKILEGLLRLFAGLPFTEDAPTHQSGLMGAISSIGKKKKNIMDRGAANSAVSNTTSTQAMLDRHSELDTPQKPYAKKGTPSDYSLSFNTAPSHMRETDDDYIMSAWRPTTAFEDSNSSDETHGNYLQRAIDSDSEDSHHRVDDEEALRGGDSPDNRTSTPLVPPNLPNSSFITSNDTLHSSQNIQSSQNNEIHSVHSNDTIDTSKRVRTRSFSAVVEVFGEQPKNYQPAEYKNVDENDHHSEVVEGIGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW2</accession>
    <name>I4YFW2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_36069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956904.1">
        <property type="nucleotide sequence ID" value="XM_006956842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW2"/>
    <dbReference type="STRING" id="671144.I4YFW2"/>
    <dbReference type="GeneID" id="18471942"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36069"/>
    <dbReference type="eggNOG" id="ENOG502S6WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120084_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFW2"/>
    <dbReference type="OMA" id="YDHCAWQ"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="11912" checksum="E547CD685A88835C" modified="2012-09-05" version="1">MSYKLIFYCPIKNTSNVLRGIFDKTTAGGIGNYTECYFKTKGVGSFKPSSEANPHIGEANKAEYVEEDKVELLTGGVDNTKKTVEVLKSVHPYEEVAYEVYRIEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW7</accession>
    <name>I4YFW7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956908.1">
        <property type="nucleotide sequence ID" value="XM_006956846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW7"/>
    <dbReference type="STRING" id="671144.I4YFW7"/>
    <dbReference type="GeneID" id="18471331"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31566"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFW7"/>
    <dbReference type="OMA" id="AGVIHMS"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="260" mass="28066" checksum="F1B502B7DF2240EC" modified="2012-09-05" version="1">MPLSLALEGTVIVSGGNRGIGYELSRSVAESGAQVAIIYRSAKDADEVAAKISKEFNVPVKAFQCDVTDQESVKTVVNKVDKEFGPVTGLIANAGVAELRPALELTRADFDKIYNVNVYGVFNTAQAVAQLWVNKKFEKGSIVIISSMSGEIYNTCAPNQALTQVFYNSSKAAVTHLGKCLAGEWAQHKIRVNTVAPGYVNTDQTKDHPEEIKSYQAKNTPLGRFCHPSEQAPSAIFLLSDKASFITGATIINDGGYTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX2</accession>
    <name>I4YFX2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_67754</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956913.1">
        <property type="nucleotide sequence ID" value="XM_006956851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX2"/>
    <dbReference type="FunCoup" id="I4YFX2">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFX2"/>
    <dbReference type="GeneID" id="18475291"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67754"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="I4YFX2"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="27"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="208"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="457"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="565"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="671"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM22864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133109" checksum="DB202E3FAC13CC77" modified="2012-09-05" version="1">MSFNTLERERTFKNPSNKGTNYPVLQELVKPHVDSFNMLFKDSNGGEGLLDKALRDIPSRVIIDDKQRLELTYTQLTIAKPMVLDKDKNSTDRRVFPFEARERLTTYKSRMSVKIQVKVNGEIKSEFIRECGSVPVMVRSERCNLQKMTSAELVQKHEESDEMGGYFIINGNEKLMRLLVVPRRHYVTSIIRPSFANRGPTYTEYGVQIRCVRPDQTAATNTMHYLSNGGATLRFAWRKNEYMIPVVMVLKALSSASDRDIFEGIIQKDYDNTFLTDRVELLLRGFKPFKLYTREQCLHFLGSKFRVVLGCPEDWTDIQVGQYLIDRCILVHLQSPQDKYRMLLYMLQKLYSLVSGESCPDNPDSPQLHEVLMPGFLYGQIIKEKLDECLIAATAQIRQDLRRQVSSANVSDDKYVNKVIQRTNFDIGQKLNYFLATGNLVSPSGLDLQQATGFTIMAEKLNFYRYLAHFRCIHRGAFFAELKTTAVRKLLPEAWGFLCPVHTPDGAPCGLLNHLSRSCKVTTENLEESASNIPSLLSSLGMIQPFVNTVDRRNSVAIQLDGRIIGWASTEDVKHMAEALRIWKTEKLHDVPLNLEIGLVPSSKGGQYPGLYLFTSRARMMRPVKYLANGKLDHLGSFEQVYMDVACVPKEIEKGISTHVEYTPTNVLSVVANMTPFSDFNQSPRNMYQCQMAKQTMGTPSTAIMRRTDNKLYRIQNGQTPIVRPKLHAHYGMDNFPQGANAIVAVLSYTGYDMEDAMIINKSAHERGFGYGTVYKSQIVDLREMRGASKSRSAPTLHFGLGVDAKQEWRETLDDDGIIPSGVKVTSGDPICAYIDETTGRTMVEKYKGDEDAYIDEIRLLGSDGGDTELQKIHFKIRIPRSPVVGDKFSSRHGQKGVMSQRWKKIDLPFSESGLQPDVIINPHAFPSRMTIGMFVESIAGKAGALHGLAQDGTPFNFNEKDTPVEYFGEQLKSAGYNYHGNEPMYSGVTGEEFPADIYIGCVYYQRLRHMVNDKYQVRTLGPVDQLTRQPIKGRKRHGGIRLGEMERDALIAHGTSFLLQDRLMNCSDYSTTWVCRDCGSLISLGYTDERDMAASQLPQGPTGEYCRVCRQAQLEKDQGELDGEVRQVERKGDIILPLSKDLNIGKGGNMDVVAVPYVLRYLASELACMGIRMSVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG31</accession>
    <name>I4YG31_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_36179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956969.1">
        <property type="nucleotide sequence ID" value="XM_006956907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG31"/>
    <dbReference type="FunCoup" id="I4YG31">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG31"/>
    <dbReference type="GeneID" id="18471949"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36179"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG31"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="31179" checksum="A126035A408E3800" modified="2012-09-05" version="1">MAIKKKKTPITKSKKTASKSISSKKTKEIINNFHQLLKRRKTTTNEVEIKDIDRAIDELGGMEAYQHASTIGQSTPRGGDSSHYFVKWLAELGVKKSYVADKEKMSLLEIGALLPDNYHSERSWIETELIDLKSNHPSIKEQDFLQRPLPSKPDDEKDAISSSLVLNFVPTPQERGQFLYRLNSVLKMNGWLFMVLPAPCVVNSRYLTRNHFISILETLGFKLVKEKIGDLQKGSRIAYWLLQKTSKPNKPPIELTKKTVLVDGPKLNNFCILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB6</accession>
    <name>I4YGB6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957047.1">
        <property type="nucleotide sequence ID" value="XM_006956985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB6"/>
    <dbReference type="STRING" id="671144.I4YGB6"/>
    <dbReference type="GeneID" id="18475313"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67882"/>
    <dbReference type="eggNOG" id="ENOG502S95K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185822_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGB6"/>
    <dbReference type="OMA" id="RFRKFWM"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="234" mass="25548" checksum="356B989034DCAE4C" modified="2012-09-05" version="1">MFGFSLSYYQERIMAAPRNTAAANKRIRKRKRRTQLDDSSSSSSSSESSSSEESGNEEEKEEKGEKVEKLALEKSSSDSDSDSDSSDSSSSSDSSSGSSSAPSIRVKGKKKTQHSVTQQQQRQSLSPQPSTANDAFIPTSIFNDSGASLSLDGDKKTENPIRTAFRSHWMATIADSFSGDLEKLSTEPHMNGDKLKLLIGALSTNNTAIQDDEVDLVLSETKNRDQDQDVKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE7</accession>
    <name>I4YGE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_15916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956849.1">
        <property type="nucleotide sequence ID" value="XM_006956787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE7"/>
    <dbReference type="FunCoup" id="I4YGE7">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGE7"/>
    <dbReference type="GeneID" id="18470681"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15916"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="InParanoid" id="I4YGE7"/>
    <dbReference type="OMA" id="TIISAKC"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="26928" checksum="1F5143420AB8D428" modified="2012-09-05" version="1">MPINQPSNQIKLTNVSVVRLKKAGKRFEIACYKNKVGEWRNGSETDIDNVVQISSVFTNVSKGAVCNNDELQKAFGTSDNDEIIKQILKKGELQVGEKERGHDLSNKWREIATIVAERCVDPATGRPVTVSMIEKAMHDVHYSVNANKNAKSQSGEVIKQIQEKGVLPLARAQMRVRITAASKDGKNVKERIKEYVNKAEDEDWSDEWEYICLIDPSSFKALNDLKLNARVEVLENSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH7</accession>
    <name>I4YGH7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957102.1">
        <property type="nucleotide sequence ID" value="XM_006957040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH7"/>
    <dbReference type="FunCoup" id="I4YGH7">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGH7"/>
    <dbReference type="GeneID" id="18473540"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59758"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGH7"/>
    <dbReference type="OMA" id="FWEMFPY"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="350"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="62343" checksum="0ADE0AE9A2A115FA" modified="2012-09-05" version="1">MDKIAGLSEAKGEVTTFENVVLPKILTIAGSDSGGGAGIQADLKSFTALKTYGMSAITAVTSQNTVKVNGVHAIPTDFISSQIHDVVTDIGVDAIKTGMLHSKEVIETVVETLNDLNVKCPIVVDPVMVSTSGHRLLNEDALNMLREKLIPATTIITPNIPEAELIQDGKIGELADMMKIAESLGCKNALIKGGHRPYRDLIGNESIDEALSKMEKLSNVTVVGYGSTAEVLEEYRNAHSGEKSNELVIDVLWESDRKHFTLFVQPYIQSSNTHGTGCTLSAALAAYLGKGMSMSMAVKSAIEFTSLGIESSMPLGSGNGPLNHMHSTKILPLSLPTSTSPAPFTTHLIQSAAEHWDDYIYHPFVKQLADGTLPKESFLHYITQDYVYLVHYARIHSLAGYKSNSFADLEAFANITQHIAKESAMHVEYCNSWGISTSDLLKTVESAHNIAYTRYLTDVGHSGTLLELLVAVASCLLGYGEIGRRLKKSALTGEEFAPGLVCKKENNPYWKWIEDYGSSDFQIAVDEGISTLERKAVEEQPSRERLNHLTDIFTRCCQLESGFWDMGLHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGQ9</accession>
    <name>I4YGQ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956547.1">
        <property type="nucleotide sequence ID" value="XM_006956485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGQ9"/>
    <dbReference type="FunCoup" id="I4YGQ9">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGQ9"/>
    <dbReference type="GeneID" id="18474757"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62528"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGQ9"/>
    <dbReference type="OMA" id="KHNIPIM"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="338" mass="36862" checksum="5EC65B335EAE3146" modified="2012-09-05" version="1">MPEVLNKEVRSIGHGLMGMTWTDTPAPLDTALEVMKRSIEVAKGGNITWNGGEIYGTPEHNSLHLLKQYFTKYPEDVDKVILCIKGGMNAQTHMPDCTYEGLSKSVDNCNAILGGVKKIDQFEPARRDTNLSPTEIVKNLARLEKEGKIGAFSLSEVGEKTIREAAEAAEGLGTKLSSVEVEFSMATTDILHNGVAKVCADHKIPIYAYSPIGRGMLSGKIKSKDDAKGMAKFSPRLQDDNLAQNLKLVAEVDNLATKKGCTPAQIAIAWVKHHSNWNGKLPTIIPIPGASSISRVEENLDDSITLSGEDMNFLQDAINKLDIKGGRYPEHVSHLNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGR5</accession>
    <name>I4YGR5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_67469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956553.1">
        <property type="nucleotide sequence ID" value="XM_006956491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGR5"/>
    <dbReference type="FunCoup" id="I4YGR5">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGR5"/>
    <dbReference type="GeneID" id="18475258"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67469"/>
    <dbReference type="eggNOG" id="KOG2851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028288_3_2_1"/>
    <dbReference type="InParanoid" id="I4YGR5"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="416" mass="48578" checksum="EC872CF8C7F37B1D" modified="2012-09-05" version="1">MVNPDLTHLDDASNPHVTRAYYERLFPFKQMYQFYNGDHIPTRLFTNREFAFTVKDDIYLRYLSFSTWDEWKKETLRLNPTRFEIGAVYTARPRDKKSLGPSAFKTKERELVFDIDMTDYDEIRTCAAGKDICEQCWGFVVAAMRILDTVLRQDFGYKHLLWVFSGRRGIHCWVSDPAARALTDEQRKALVGYIEVVRGSAQQAKKVHISQNLPRGAPWHPSLMRGYEQLYECFEKTVLEDQDAFRDDPAWRTLLSLLPDQDVAKSLSNEWVNKPGLNSREKFKQIRKRMPKSPQWDTALREIVLQYVYPRIDTEVSKHQNHLLKAPFCIHPGTGKVCVPVDVSKAEEFNPSKVPTIGQLLRELEQLPATAGRDVSQDWEQTSLAPYIRMLDKQSEQIMAETRRFKREMNNRSLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE2</accession>
    <name>I4YHE2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956764.1">
        <property type="nucleotide sequence ID" value="XM_006956702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE2"/>
    <dbReference type="STRING" id="671144.I4YHE2"/>
    <dbReference type="GeneID" id="18473439"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59586"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_0_1"/>
    <dbReference type="InParanoid" id="I4YHE2"/>
    <dbReference type="OMA" id="EELRENX"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="108"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="578" mass="65029" checksum="3EF4F44382D0D8C6" modified="2012-09-05" version="1">MRSLTMLQDTPSLTSVSADDTTDDDLKNNQSGYSTPSRFKFDKPSHHHSDRHKSRLAPIHDLKKLLHSHHNSPCTSSSSSSSLHRRTSSHESSTDLGEDHAHLTRKYGKWVKTLGTGAGGTVRLIAKKKHSLSRSSSSLSSLSNTPTIHAVKEFRARKQGETQKEYVKKVTAEFCVGITLKHRNIIQTVDIISEKGHYYEIMEYAPYDLFSVVMSGKMSRGEIYCVFRQIVDGVDYLHNMGLAHRDLKLDNCVLTSDSTVKLIDFGTATVFQYPGKKSTKATGVVGSDPYLAPEVLYSATESAQREGLKEYDPRLADIWSIGIIFICMLLRRFPWKIPEEKSDQSYALFVKAHPELCEPVIEDDNSCVKSTSNTQTQWTEIQTNFDEFDLNNCHANDERCNKDLSDRMFPIPCQEPTSLPASPRESKLEDPRSTTQVRSMTMSNVAVAVENVPKATSKRPDIRHRSASQSTFINGNSDSIFRLLPREARDCLRRMICPEPKRRSTLNDLLRGGEQLLNLTDGLDLHGDLSRPEFGNDVKRTNDLDISDKWLKSIDSCAIKPSLNHSHTVVETVDSKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE3</accession>
    <name>I4YHE3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_67645</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956765.1">
        <property type="nucleotide sequence ID" value="XM_006956703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE3"/>
    <dbReference type="FunCoup" id="I4YHE3">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="GeneID" id="18475277"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67645"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="InParanoid" id="I4YHE3"/>
    <dbReference type="OMA" id="PWLDQPV"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="303"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="583" mass="65278" checksum="C5AF4183A8A9067E" modified="2012-09-05" version="1">MAINKRGEVCIVNYCCTGWKCNNKDLSHQDAAPIYGLVIGLALLGLILSVIALQQTKFYLAKHPQKKKQLPSFIRKISALSRASKYHSFKIRNWYLPHTIALIGIFVLFLWLTVWAFATLPYYSHDFETEKPPLATRAGSLAVALIPFIFTLGSRVNPISLATGISHEKLQTYHQYGSRILLFISLVHGIPMLLQPYYEGYKTGGYAAGRTRLQEAWESNAHFESGTVLIVFLVWINVSSMRVFRRISYEFFVFQHVITTVAFLANLFPHVNVTYMDAWNYLFAAVALVLYSWFGRLAITIYSNKLSTSHAQLENLTEGMTRLSIKTKIKWKPGQHIYIRFPFLKPLQSHPFTITSIPSTDSEHSVIQLLARAKNGMTKVLHDRAQEGNTYLPCFIDGAYGGSIPLDGYTNVLLLSGGTGITCNMPLLLDLIQKMEAGKSACQHIDFIWSIRSKKSLEWFDATFRSLSRLASYQNVRVRVFLTGDKSAPPTSSSIATSISSDSSSSITEKKLYEIITSRPDLEGLLNESARQSAGTSLGLSVCGPKLFNWKVMNKVADIELGIAMEDSCLPTTLYAHSENFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL0</accession>
    <name>I4YHL0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956824.1">
        <property type="nucleotide sequence ID" value="XM_006956762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL0"/>
    <dbReference type="STRING" id="671144.I4YHL0"/>
    <dbReference type="GeneID" id="18472816"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56507"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_1_1"/>
    <dbReference type="InParanoid" id="I4YHL0"/>
    <dbReference type="OMA" id="WEFAPEM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="394" mass="42580" checksum="0FF3EB64B0753AC0" modified="2012-09-05" version="1">MTSVVIIGGGIIGVCTAYFLSKEDGVDVTIIENTDIACGASGKAGGFLAKDWHGSATESLGDLSYDLHKKLSNKYNGEQRWQYRNIQSSNVLLKAIKSTNDNKPKLNVVHDNDEPFRPRPPAKSESNIDWISKPLEDARGIISHEMVSDEDTTSQVDPYLFTTSIFEEATKNGTKFVKGIAKTYKNNVITLESGEELPADKLVLAAGPWTPSVFKMLFPQSEFDLPIDALPGYSLILQPNNLPAPHAAFTTILGSDSICMSGTPELFSRPDGSVYVAGENEGPELPSTAGDVNDVALTQKERWDMLLSAVHELGPSLANANVLKKQLCYRPITHRKRPIVSSLKSVVGDNVFVSSGHGPWGISLAPGTGLVLSQLVLHGKATSADISQLTIENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ8</accession>
    <name>I4YHQ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956178.1">
        <property type="nucleotide sequence ID" value="XM_006956116.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHQ8"/>
    <dbReference type="GeneID" id="18473240"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59237"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_1"/>
    <dbReference type="InParanoid" id="I4YHQ8"/>
    <dbReference type="OMA" id="CIHAGHT"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="801"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1396"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1217"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1353"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1555" mass="172002" checksum="6B5383E86AFE12CB" modified="2012-09-05" version="1">MPGGSRDKHNISQSIHSHTSPARSTSVAVDIDKPYLPSIYTGMNTSTDDDHLSNPDEYDWALFMSAYAAGRWDPFEIPRPPLKTNSATLSVDSRRTYSAHRALDKIDGFTTSRRRSSINESYLPSNPSTFLEPQSPSNSTPVSGQKTRSAPMSHASSVSEDIDDNETSLYPINLSSTQQNLAFGPDLAVQVATHSLIHSDDINKKLFKGTEDATDRPASAPEGSKQRDLKSALPSQTYDDTKHSSTGYMDYVSPTPQSKVAPLNTNDRQFSYESELSTDTSTPTNTRPHFLNREDSDRTVMNDTTPSRQPDQPDLDKLTEAFDHQHIIDPTSPVTSVKALPIEMNSIKDPIPSRLSSDRIQNLAEKQFSELSYLVPPLPLNEDARRKELFKFDLLRGTPDLSLDRILHLVKLVFQTKCVIISLVNGENVVLKAHTGYEEMFETDIRVNEPRKTALSSHAILQQNDEPLVSLDITKDWRFSKNPSFSPKARFYAAAPIRTYNGYNIGALALIDSQPRTEFTPRQRHTLKEFASIVLREMELWRDKCQMRTRDLIQSSMEQFNRDILEMNSAGNTKSSNVSDMQKVYDKAATLIKDTLGVEGALVLDISQFEIAENLGDDNELYMPDPITQSQRETPTRTSSSSNLNALKRENRSQSQWPPINRSGSDDAYARSIPILAAAEDGPIPSNRFQPVSEENSEKLAWFLKRNPDGYIFDYGLIPGVFRQFVGVKEKYGMAIVPIFNLSNDKDGPFALLVAYTGDRKLLLEGYEIQFLRAMGVIILSAVLKERILLADKAKQNFISNISHELRTPLHGILAAAELLQDTELDEVQVEFLDTVKACGRSLSETLNHVLDFTKLSGSNTSAGVERGIKLSKVNLKNLVEEAVESTIIGYRGRFAASSEGLGDIYAPPSSSSSSSPSLTTQKVDQISKSIPVEILVDVQFRSNWNCKCEKAGLRRVLQNLVGNSQKFTKSGYIMVILREAPHSPGSKKLPIEIVVIDTGKGMSKSFLDSQVFQPFSQEDPLQAGTGLGLAIVSSIIKSPSVNGQIDIRSREDVGTEIKMTIPVEMIDNKSEEEEKSLTQENIIEKLGYSSNWKPKVTLHGFDTNSMGGEALINVTSNYIRSWLGLECALSTPQNNVYGDILVINEAQEMLLALIQEREFSKPIVLISSSRADKQLYKAKVEYERLGGIARIIYKPAGPTKFDSVMIALINSLAQRSGHARTEKRSNSNFDFFRNLPMPSPAESSGSNKSDYFSEANQSYNSSSGGTPDDHWREQMSEYLSPSGQRTNSTENLMSIQRRNSDKSTQPSANLPTRPSMTPRSVTYHVSPSTSQLNHNRSVSGTWSTFSGHSKDNNSGTHNGSSPSTPGSTISISGAGAILKTSAENEPVKAHGQPFRVLCVDDNAINLNLLTKFLKKKGCEYVEATDGKQAVDIVNSTGPGYFSVILMDVSMPVMDGLQATSEIREIEHQRRKEMREQKDKFGQKSYLNAKSGEVTPPAKIFALTGLAAKEDRRRAFAAGVDGYLIKPASFKSLDLLLSRIGVSHKAPAPTPPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU5</accession>
    <name>I4YHU5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_62207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956214.1">
        <property type="nucleotide sequence ID" value="XM_006956152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHU5"/>
    <dbReference type="FunCoup" id="I4YHU5">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHU5"/>
    <dbReference type="GeneID" id="18474721"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62207"/>
    <dbReference type="eggNOG" id="KOG1895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008962_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHU5"/>
    <dbReference type="OMA" id="NVRYGIM"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="864"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124114" checksum="C16E136D4A63814C" modified="2012-09-05" version="1">MVDPNELLPPLKQALDNPGLDPIIAVQSLDILIQLFWDKSVDALYKQQVVLCLASAYPHILKFSVQHHGQSQAWFKFQGVKASILPLIDQKTAPLGLRLSAIKFAQRCVALQSRPQNRGSSKDTSIILVHGNHPYIDTTGLEKENTTTLHALLTLIFTPQKLSIVTATINVLGILARQRPQYAAAIAPALATWTPAPLQTMVNNPSQLKSVEKLLYGVLKHLVKVGLTGNSTPTVMESLSKQAHRIEQLSREEQIKKKAMKRSLAEAAPSIKSLDLKRQRTNDQLPHVFGGSSPKIDIDVTKLPLETVVEGLIESLKNVSEQDLEIAIRKSRERIKTEEMKSSTSEQGQPSHTQTISEAGPSRQPQEAMEVDVKPIDPLKVEIDDDELDDDVDGINRNLNDTVAPSGEAQQAIQNQSSAVNTGTKSKAQSLLSAMQKVQNPTSLDNNDRLLVIRNAIARICKSIPQKVLTDSAEEDIRRSTIKFYGRDLWSVVLVRLLTRGLSSISKDTEDEQLQLEKRAKDTLIDFISLDFDRRFSIAILWLNEEWYNYTLRKKDDSEANLDSYNELLTILVERQISQLSNNSSSISSAAFVKFIMDLPVISQDSLNKIKEICLDSESLKAPIGFVILRELVSMRLPVRQQSLEILLMLAVHPDLKTRRAAVNSVRKWVPENEQLSPKVIEFALKSLHSLYQDQEDFLSSLVVKKDDDIEVKKEKEDDRVVKKERSDSSQPMEEDGKEATTPHLEITAEERAKAIDTRVLERSELAFSLCLRSTDILKDVFAVYTKLSLDLKEPFERALTPLIRGLGSSNKSLLSILKTFNQESEPLALRILNVLTDFGKEKPSPELVTFIRELGAERGGEVDPRFVIPILQELTKDEMITELPRIVKLLKDDENKQLIKNVFSSVVEPPQSFGSVNTNVVRVDKDKPDKITPAELLTILHERETEIGLKETMIAIAICFSLTDIFRSDVLAIFMQSMSEVKVLPKLFMRTVIQAVTTYKTLVPFVSTNLFSRLITRKIWLTPVMWEGFVRCARAIAPASFGALLQLPQDTLRDVIKKQPALRSGLHEYILRKAPKSSQILKIFEELPPATATPSQNSRESSAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU6</accession>
    <name>I4YHU6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
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                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
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            <dbReference type="PubMed" id="22326418"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
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        <location>
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        <location>
            <begin position="239"/>
            <end position="310"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60543" checksum="D962D92A79C5EAAA" modified="2012-09-05" version="1">MLPLLQDDLRQTNVLSWSESDVSLWLQHLNYSQHLHMFKENEITGEVLVHLDHEALKDLGIHSVGTRLNILREIYHLKVYFDISLEPEHYVPPSELINETKAKVNEYTNLISKVMIQEDRLNALESDYRRLFKTFEATYDELSSIKHTSLSSTTSVNTNTSNALQSFKSPDYEHQLSPTAITVSPAPNSAPANTNTQVDSAKEEDSEDKPSNGLIRQASLGGLSRAKSYKDQEGKAKSNVKVKLDDSCWKVLPAALRKYKIDDDWTKYALFICYGKTERCLSYDERPLQLFQRLKEQGQQPVFMLRHVKELRSPISIALQKQQAKREANSSLTPPPSSSQQQSSPTTNNVASFRNGKALAEVCDSDDIEGYAIAIYPYTADREDEFDVNVSDQFEIVQRAKGWWVVRRESMNEVGWVPTGCLLEVSNLTSSPNQIQILSNSYGATALMNYQPNSKDECGLQKEDKLRVYKKHNHWCYVVKDSNGERGWAPSWYIGSNKSRDTNSANQAGSSQGNMPLSAAGALTAEIDKETSSPSTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU7</accession>
    <name>I4YHU7_WALMC</name>
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        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
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        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956154.1"/>
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    <dbReference type="GeneID" id="18473250"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59251"/>
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    <dbReference type="OMA" id="ARQGCRW"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="129"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="131" mass="15163" checksum="57C7FD5EFD8D7D7B" modified="2012-09-05" version="1">MNQRFKADNHLRDRASLLGPSAHQQRSDSPFYDHTRATQDMENQNDEHLDGLSSKVRLLKDITLSIGQEARDSAIEMGSMNDSFESTGSLLSGTMSRLKHMSKKQGGRCYIYTIFFLIIFWVFIITWFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW6</accession>
    <name>I4YHW6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
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                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956234.1">
        <property type="nucleotide sequence ID" value="XM_006956172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW6"/>
    <dbReference type="GeneID" id="18475223"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67211"/>
    <dbReference type="HOGENOM" id="CLU_1817297_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHW6"/>
    <dbReference type="OrthoDB" id="4566586at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697816" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="15844" checksum="97CD3218C537B5DD" modified="2012-09-05" version="1">MKFTGLLAIASIIAGTTATWSDGNGDVDDNSFTVIIKDPWKSGLDHANTAAVSVNTKEHTTPFSTHNTFTIYGDHCTQYIGLPARDDLPYQPQIHLGANFCNRKNKDNLWINYANQHLDVTSDTRCIKQYNKTVRCTILKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YID5</accession>
    <name>I4YID5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956392.1">
        <property type="nucleotide sequence ID" value="XM_006956330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YID5"/>
    <dbReference type="GeneID" id="18474746"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62396"/>
    <dbReference type="HOGENOM" id="CLU_534429_0_0_1"/>
    <dbReference type="InParanoid" id="I4YID5"/>
    <dbReference type="OMA" id="FRTTRND"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="57025" checksum="938F015812B9CF29" modified="2012-09-05" version="1">MSLLNRIAGTSTDLRDRLGPAVQQNNKRERPSDATPSSKKFKPLESADKSLEKPAEKVVEKPPAEKVLDKPPSEKLVEKVPETAPESSAKKSDENSTDKSSEQPPQETFVEKYDSLATQLNSLINKNFEVKRIEDETVRTFEEKQTLISLSKDNFFTIPSTNYQSDLSKLDMRLTYLDTSLKSTMKMANIIALNLVSNLIGFAKTTDSPISQMNAESQISSETYNSFRNQTENTIKTIINSNKNNSFKITEVEKLVDSFKGQINEAKSEIFETNKKSYDDFVDYTRDKLKTLDNKIINIGTAHNGLTKDLNSQSSLVTTLSTSTEENKMDITELQDFKQTMEDNYSTLFGMVKEQKEQITRLTNENEKLQQSNRGMQIVVNQHKNQIAAITRNSQNGQNGVARSASVTPSQGTSNAANLASVPHNKGNPASRSNTPAPQQLIQRVSQSPREQQPAQHPHQKARHSMPPHPNTARPPPTGPRQSAPLAQRMQPPSNRNNKPLPPHLQKGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIK9</accession>
    <name>I4YIK9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956464.1">
        <property type="nucleotide sequence ID" value="XM_006956402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIK9"/>
    <dbReference type="FunCoup" id="I4YIK9">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIK9"/>
    <dbReference type="GeneID" id="18473345"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59422"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIK9"/>
    <dbReference type="OMA" id="DRYPPMR"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006215">
        <property type="entry name" value="Glyco_hydro_melibiase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00748">
        <property type="entry name" value="MELIBIASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698971" description="Alpha-galactosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="336"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="47048" checksum="6E276CD5EF883EA1" modified="2012-09-05" version="1">MFLRTLTTTALASLLGSVLALNNGVAVTPQMGWNSWNSFACEIDQDLITQSAQKLVDLGLRDLGYTYVGIDDCWQADARDPETNKLSYNAEKFPDGIKGVADQVHGLNLKLGIYSSAGTLTCGRMPASLGYETEDASSYAEWEVDLLKYDNCFNQGQSGTPKLSYDRYNAMSQALNATGRPIVYAMCNWGEDGPWNFATTIANSWRTTGDITDSFTGEDDRCPCKGNEGLDCKLAGYHCSITNILEKSVSLGQKSFSGAWNDLDGLEVGVGNLTATQSRSHFTMWAFMKSPLMIGANLETIDDESLEILKNKAVIDVNQDAGGDAAFRVWKREVGDGDVQLWLAELSDDNYAIAVLNTSSNEQTTDVQFDELFRGIDFKSGEREATWNITDLWQKDGENWGLNLGSVSGAIGEISVEPFGVVAYKLEKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP0</accession>
    <name>I4YIP0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_66738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955679.1">
        <property type="nucleotide sequence ID" value="XM_006955617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP0"/>
    <dbReference type="STRING" id="671144.I4YIP0"/>
    <dbReference type="GeneID" id="18475139"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66738"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283735_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIP0"/>
    <dbReference type="OMA" id="RYQKYYE"/>
    <dbReference type="OrthoDB" id="3364015at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="318"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="921"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="833"/>
            <end position="846"/>
        </location>
    </feature>
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        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
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        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
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        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
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            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
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        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1097" mass="121098" checksum="2447691C0F9BBB1A" modified="2012-09-05" version="1">MNNEIARLLQQQQFNQLTPQQRQQAIIAGQMNRLQQQQSGLLNQQQQQPQPSAPNNDFNNSPAFQQQIQQAFQSNNLQFLVEAAKSNKLNNENIQRLQKLIRHRQLQQIQLQQQHQQQQQQQQQSQQSQLPQFPNLVPSQIAAAKNLQQKIETIDLQLRNPSLSPQDRDNARKAYEEAKNLQALFIQQLRNSQQKPNPAATTAAPSMVHSQSQPQLGSNYVNENTFSNMMPTNSQSNWPNQQQQAQQSQQPQQPQQPQQQQQQQFPSLSNNINGDNQSNMLGLGLVGASNTPQQQMPASQTPTQPSPQMRPNLSMAAQLQPDNFLKALIELMKKRGTPIEKLPEVDGKGIDLHKLYMTVVHSGGSLEVHRQGKWPLIGAMIGLPLSTQFGESSPRVSNNNAQALANVYREYLAPFEQVWTKALQDQLAQRRAAMMQTQQQQQSQQSPQTRPVTQFPQSTPAPQFPQQATSSAPNKTSTPTQQQQQQQLMASLSTMSDEQLRGLNITPDQILQLRRKIQQPQMSTPVIQPQQMAPTSSIPSAAPMDANILSSASASANAGASASMQANASASEAMQQTLSNNMPTIMMPPKERLAQASQLVQSIKQSIMQQRPPVNSQPNLSPQEQHQIAQVCAEIKPMLISLENILPIFLCLNDPIEPGKIEAVKKISLMTVMYYQQTIMLPQRQFCFNLEDMSRLRIQLARCFMYVKSQVKDVQGIGNIAQGASVTRPASQPPPIPTQSSSQVAPDPTAMLQNALMQQQQQQASQAQSMTGIQRPNDNLKAPPSKRARTSPQIQTQSQPIDLSPSPASQPQQVASQFAQVGATPPKSPYSQRAAALTAARGATGRSRGKPQPRPRNASRGSESNNTPINIDMDSPVTQNQPVMQPTPSQQPPQQQIPQKPTALEDPVAYLENALADFKNNFPASGSTPSTSATPSVSNPEMFNSLGEDSEFKPSLTLEDVHSKPEPEFILSPDDNNEGGELPPNEELDFSLLIDESSFNDVDNGDSGDGPRKVNVETPELINGTNPSPESINEELKSPKDATANGKDVVGKGTNSDTSSTTTQDWFSGRVNNNDQFDNILDNNMSANWLLQDEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT3</accession>
    <name>I4YIT3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_34357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955719.1">
        <property type="nucleotide sequence ID" value="XM_006955657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT3"/>
    <dbReference type="FunCoup" id="I4YIT3">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIT3"/>
    <dbReference type="GeneID" id="18471859"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34357"/>
    <dbReference type="eggNOG" id="ENOG502QQBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIT3"/>
    <dbReference type="OMA" id="CSEEHWA"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="49385" checksum="3938C8E68A3B1622" modified="2012-09-05" version="1">MTSKARNLLGFFKNQKFKQNEFGTLKTLFHPLNESPIPSLRALGERISNKGKCPIEGVGPLKYYCPISGYPTHSSKEAYEKDSHHRNTYATRLREVNEDEHDLRSGREMKEFEMPGLQDIEQTVNLKSWEMLFYTRNFNSVDNLRSQRHLSRLLSYPMTIAGILHELGPYADRAGGRVTPHGERSLLALRYMLHKQPLPYSPPTPPIRIFIPGARAESQLPSSVWMQLAHLFPYARFQIYFVGPEVVADEVVSPYGVKGWQKVVDTQLTLNGIQANWEQIHDTFFPFDPFTDIFFNFHPGLGFPSMLPESIRPSEGLSDSRNELVNYRQYTPQVDAEWAKALDKMLETKCPIILTAFSPSDMKRDFDALLHSEAITQEWESVVEPGDNVFGSQRWEVAEFDTRVMIKSNWGLWGIRGRRFDLQNVSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX3</accession>
    <name>I4YIX3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955756.1">
        <property type="nucleotide sequence ID" value="XM_006955694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX3"/>
    <dbReference type="FunCoup" id="I4YIX3">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIX3"/>
    <dbReference type="GeneID" id="18473119"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59005"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_4_3_1"/>
    <dbReference type="InParanoid" id="I4YIX3"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="37"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="39756" checksum="D7742145873194DE" modified="2012-09-05" version="1">MRRTLLPAFKDARRRLILALESSADDTCAAVVSSHREILSNVVLKQNNIHEQYGGIHPLYAVQGHMMNIPQAINDALRLSNLSLNDMDAIATTQGPGMPGCLQIAIVAAKALAGASNKPLIGVHHMQAHALTCTLTEKTPPEFPFYTLLCSGGHTMIVDSESVHKMSILATSHDDSIGNAFDQAAKLLNIPWSLHPSNAPGAALEVFADQENIKANEVALIKEYRKKLRVPAPGQLLFSYSGLRSAFGRLVEESDKTEMTRKALARAFQAAAVAQLKDKIELALDNAPSKPSSLVVSGGVASNGYLRKSLTELTERQNMSIYFPAPSLCTDNAAMIAWAAHYKLANEDFSNPCTLMSRPKWSLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ14</accession>
    <name>I4YJ14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_59024</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955793.1">
        <property type="nucleotide sequence ID" value="XM_006955731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ14"/>
    <dbReference type="FunCoup" id="I4YJ14">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ14"/>
    <dbReference type="GeneID" id="18473134"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59024"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJ14"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="71"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="471" mass="51098" checksum="3F0465AE59376769" modified="2012-09-05" version="1" fragment="single">MEATGQPSQIPKGNISARDNRVATHSHIRGLGLREDGSAVIGTGSAGWVGQNSAREACGIVSDLIKLRKFSGRALLLAGAPGTGKTALALSISHELGTKVPFCPMVGSEVYSSEVKKTEVLMENFRRAIGLRVKEVKEVYEGEISELTPAEAENPLSGYGKTISHVVISLKTMKGTKQLRLDPSIYESLQKERVTVGDIVYIEANTGAVKRVGRSDAYATSFDLEAEEYVPLPKGEVHKKKEVIQDITLHDLDMANARPQGGQDIMSVMGQLVKGRRTEITDKLRGEINKVVNSYIEQGIAELVPGVLFIDEVHMLDIECFTYLNRALESTISPHVILATNRGLCTVKGTEDSGGEGIVSPHGIPTDLLDRCMIIKTTPYNKDEIKTVLSLRSKVEGLKLGEAALDQLAEKGAQTSLRYVLQTLTPASILSKNSNRAEISPEDVSELDDLFIDAKTSADFTAVCLYSHLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ19</accession>
    <name>I4YJ19_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bud site selection-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_66837</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955798.1">
        <property type="nucleotide sequence ID" value="XM_006955736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ19"/>
    <dbReference type="FunCoup" id="I4YJ19">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ19"/>
    <dbReference type="GeneID" id="18475159"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66837"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJ19"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="14363" checksum="38DAA8E6C6606233" modified="2012-09-05" version="1">MPGPSRRSRTGASKRDIHRASRTRARTKDLDQVQLEDLLPENKAKLENQPLDETLPGLGQHYCIECARYFESDVALKGHTKTKVHRRRLKDLKEPAYTQAEADAAVGLGVDKTQRSLNNDGQAIKIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ44</accession>
    <name>I4YJ44_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_34503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955821.1">
        <property type="nucleotide sequence ID" value="XM_006955759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ44"/>
    <dbReference type="FunCoup" id="I4YJ44">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ44"/>
    <dbReference type="GeneID" id="18471867"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34503"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJ44"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="335" mass="37906" checksum="FDC93612457F27CF" modified="2012-09-05" version="1">MVEKMEIDSHKSDLPWVEKYRPNELDDVVSHTEIIQTINQFIQKQRLPHLLFYGPPGTGKTSTILAIAKKIYGGNWKRNVLELNASDDRGIDVVRDQIKSFAQTRTLFSDGFKLIILDEADLMTQQAQGALRRIIEHYTPTTRFCIICNYVNKITPAIMSRCTRFRFSPLPYAHLDKRLVEVIENEAVQIDDDAKKALLNLTKGDMRRALNILQACHTACMPERISIKDVYNVTAAPQPEAIEYIVNTLLKDEISTCYSKIHQVKRQNGLALQDILTGVYDYIQTIEFPTATKVAILELLAEVEHRLSKGSSETIQLSALIASFKLSLDIAAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ92</accession>
    <name>I4YJ92_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_13720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955653.1">
        <property type="nucleotide sequence ID" value="XM_006955591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ92"/>
    <dbReference type="STRING" id="671144.I4YJ92"/>
    <dbReference type="GeneID" id="18470617"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13720"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="InParanoid" id="I4YJ92"/>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="233"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="37968" checksum="48AF5DDB79DE74C6" modified="2012-09-05" version="1">MSNELSPLGIAFSGALGAVVSNGLVYPLDTFKTRIQARDANNKEDSEDNEDEEDSELSNELQLIPKDSLIKGVIDIFRKEGIAAAYGGFGASMINTFSQQFAYFYWYGAVRTAWIKSTTKNGQPVLLSTASELLIGALAGDLAQIFTIPVNVIATRQQLGKQDSSSDQDSDFVSVGRQIIKEDGITGLWRGLKPSLVLSVNPAITYGAYEKLKSAVIGGYIPLLSSLSNEGRMSPWGNFILGALSKTAATVATYPYIMAKVRVMAGDSVNEDKTIRSEQDKKTLKKNAGALKLLLQIYKKKGMIGWYKGMHAQIVKAVLQQALLFVLRDIFEKYTLMGVLILRGLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJQ7</accession>
    <name>I4YJQ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_34813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956018.1">
        <property type="nucleotide sequence ID" value="XM_006955956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJQ7"/>
    <dbReference type="STRING" id="671144.I4YJQ7"/>
    <dbReference type="GeneID" id="18471885"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34813"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJQ7"/>
    <dbReference type="OMA" id="FQGPIAC"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="178" mass="19796" checksum="B885C248800F0157" modified="2012-09-05" version="1">MPHADAANIDSYRPKQEVYDDILTNLDSLLTGQTNWISNLSNTASILFWTLKEINKINWAGFYIYNKSTKILELGPFHGLPACQIIKAELNKGICADTFCKSQPILVPNVDEYPGKHIACDSTTKSELVLPVFSSSGTCIGVMDFDSLVLNGFDEVDKVNMEKITHLLTEKCDFSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJT6</accession>
    <name>I4YJT6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956046.1">
        <property type="nucleotide sequence ID" value="XM_006955984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJT6"/>
    <dbReference type="FunCoup" id="I4YJT6">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJT6"/>
    <dbReference type="GeneID" id="18473202"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59156"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_46_2_1"/>
    <dbReference type="InParanoid" id="I4YJT6"/>
    <dbReference type="OMA" id="IQIHKSM"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000647">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="508"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="616"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="707" mass="80768" checksum="021E90859E8B287C" modified="2012-09-05" version="1">MKSPPRPKSTKLSETCPPPPETIHDKKRGKSYERHGLLGEGGFARVYEVEDERGYRLAIKTISKSALQSKKNRTKLYAEIKLHKALSHPNIVGFEECFEDDENVYMLMELCKSGNMMDLLRSRKRYTAPETRFFLVQLIGACQYMHEHSVIHRDLKLGNLFLDEFMNVKVGDFGLAALIEREGERKKTICGTPNYIAPEVLFDTSNGHSFEVDVWSIGVIMYTLLVGKPPFQTKDVKEIYKRIKDNLYEFPIDDPIPTEAEDLISCILTPDPNDRPALHEILDHPFFYGITPSSIPTTARISRPDFSSVTSAASRQNMRRLRQQVELDISRPIAAKNGEERTESVSVAEQEREFNKAVAPSSPISTLLSSARQPLIVANSLPSSQPLLRQATTAALAEQQKKQKADIQAANKKYIDNLKESNTDEEKLADQKLRIVSGMVNNDEKNKGKSKAVDENNEVKPKRTSKSSCFVEMHQNLHNAFLSKKEARKFELPEEYKKIDVESASKVFIVSWLDYCNKYGMGYALTDGTVGVYFNDSTSMVLAPIKTRLDYIASKGKSSMAIRKNYTVDSEENALPKELESKMMILRHFEDYMLERLYGSRSYTFVDEQRRKGMTFVQRYYRMKNVIVFKLSNDVVQFNFYDHTKMILSMGGCLISYIDKDYALSRWTLDEIFQQDGDKEDKKKMEGILVKLKYCRDVFATTSGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJZ6</accession>
    <name>I4YJZ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_30975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956100.1">
        <property type="nucleotide sequence ID" value="XM_006956038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJZ6"/>
    <dbReference type="GeneID" id="18471223"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30975"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="InParanoid" id="I4YJZ6"/>
    <dbReference type="OMA" id="FPNLAWA"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="56454" checksum="098C464CCF6359AA" modified="2012-09-05" version="1">MFFDKLKKNQVETQMTEKVDTTELPPIELELVGQELPFNWPFSRKVKSYIIALLINFVSAFNATGNSAARAGVTEEFGVSSSVFLTSSFTYNAALGLGPLFLAPLSEQYGRRPMLVSLLLLIVILFLPQALAPNISSLSISRLFQGTAASIEGPHVAGIISDLFHRDGGRGIAMATFTLVVFTANAIGPLTCNWLASETDWANIYWMQMAMNGVVFIMCAFMLDETRHDLILDKKITKYNKTYGTDLKVQTDAAHSVKKALTTSLARPLIYLTTEPIVIALSIWVGFAWGIVFLSTGTVLHVFEKTYDFTQGQGGTVLICGFIGAFFAWLVGFGQNVLYKKSKDPVTHIAPPEARLYQAALGAVLFGAFELMFAWTARPHIHWIVPCIALVGVNFGIFPIYAGVYTYIGDAYEKYSSSAQAAQALLRNILGSTFPFFGTAMFDHLTFPWASSTIGFIAFGLSIIPFVLILFGGWLRDRSKVCRQILKEQEEEKLRKEEQEFSKPGDKNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y533</accession>
    <name>I4Y533_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PMR-1</name>
        <name evidence="18" type="ORF">WALSEDRAFT_61655</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="JH668262">
        <property type="protein sequence ID" value="EIM19075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960882.1">
        <property type="nucleotide sequence ID" value="XM_006960820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y533"/>
    <dbReference type="FunCoup" id="I4Y533">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y533"/>
    <dbReference type="GeneID" id="18474662"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61655"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="I4Y533"/>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="898"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM19075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1033" mass="112271" checksum="F6CCE90DEC42FCBA" modified="2012-09-05" version="1">MARDRKRTNSGTSDQKPVKPVGSASSTLYNSQPEGLKSYQYPAVVPPTAEEAARLAHQTPPHTQPTTVADAEDMFAYSTTFRKTSIESLAHKPSITHLKPSELPSAFDSAAAEKEEAEERRRMLVHSLESDPAHSSTPSAQYAKLSVEQTIAKLNTHPKNGLSTADVQELRHRYGFNEFSVEAGDSLFKKFFQQIYESPLILLLLGSAVVSALVGNVDDAISISLAVIIVLTVQFVQETRSEKSLQALNKLVPHYCHLIRGGQLSSPLANDLIPGDLITFSTGDRVPADIRIIEAVDLELDESNLTGETKPTKKTTVPSTHMNVGVSDRNCIAHMGTLVRSGHGKGLVVGTGSETEFGVVFTMMQDIEERRTPLQYSMDELAKQLSLISFAVIGVIFVIGIIQSRSWLEMFTIGVSLAVAAIPEGLPVVTTVTLALGVLRMSRRKAIVKKLPSVESLGSVSVICSDKTGTLTKNVMTVTKGFTVPDGPLVLENKLDKISPALERTFLIGNLCNNARKDEHGHNVGQPTDVALINIVEEQGMVDRRTTFVRRHEQAFSSDTKVQFVTGTLASDTDGVPAECNYLKGALERVLERCDTYLAASGHHTVPLDDATRNLIFARAAECADKGLRNIGMAYRISSNVTDFTGGFVFTGFQSMQDPPRPGVAASIASLQRAGIHVVMITGDAERTALAIARELGLCVRPSSPITNSRRDTSECLTGAELDTMSERELMERINSVSVFARTSPKHKMRIIGVLQKLDKVVAMTGDGVNDAPALKMADIGVSMGKGGTDVAKEAADCILVDDNFATLLPAVEEGKSIFYNIQNFLSFQLSTAVAALSLITISTALRMRNPLNAMQILFINVIMDGPPSQSLGVDPVNKSVMKRPPRPKNASVITQRLLTRVLFSASIIITGVLFIYAYEIGDGFSTRDQTMTFTAFVVLDLASALQNRGVTCGFGDNKMLLTTVGVSLFAQMCFVYIPALQAVFQTEALALRDLGVLGMLVLFSIGLHEIRRRWEREQERKDALFSFSNDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y566</accession>
    <name>I4Y566_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960835.1">
        <property type="nucleotide sequence ID" value="XM_006960773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y566"/>
    <dbReference type="FunCoup" id="I4Y566">
        <property type="interactions" value="969"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y566"/>
    <dbReference type="GeneID" id="18474645"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61629"/>
    <dbReference type="eggNOG" id="KOG2948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y566"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="343" mass="39048" checksum="A957ADF6DCAB3E06" modified="2012-09-05" version="1">MVDVSKKVKLDGQSSKVIGTHNGVFHADEALAVFLLRLLPEYTGSAVTRTRDINVLNQMDIVVDVGDVYDHGKLRYDHHFRGFNEVFGHNHNTKLSSAGLIYKHYGKQIISKHLGWSEDEDRTLQIWLKVYKEFIEALDAIDNGVSLYPTVENLPEAAYRNKTDLSSRIGRLNSNWNEEFTEQSQMTRFEEASKLAGSEFLDSVNSYAKVWLPARDLVVEALSKRKEFDESGKILVFKTFCPWIDHYFELEHLPQFEVKKDEEPLYALLPDSNRGWRVRAIPPNSTTFALRKPLPEPWRGVRDEKLAEVSGVPGTIFCHASGFIGGNDTYEGALEMARKAVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5E6</accession>
    <name>I4Y5E6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRO1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960760.1">
        <property type="nucleotide sequence ID" value="XM_006960698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5E6"/>
    <dbReference type="STRING" id="671144.I4Y5E6"/>
    <dbReference type="GeneID" id="18473082"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58874"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007181_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5E6"/>
    <dbReference type="OMA" id="VSHAEEM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="765" mass="86944" checksum="CE103AE96D4B2B71" modified="2012-09-05" version="1">MNQLGIPYKHAKDISKDIVQSFNNYLNSKSIAPEQFEGDINRWTHLRRQSMITHDTSTFMEYYNQINHLLTKLPQDIDLNFEFSTPFPDSSAFSVAENYAQSDINYEKCALLFNIAAWYSQKATHQSRNSTESIKGALQDLQLSSGVFDLLIENLSSLKTPTTTPDLSPNYLKVLSILMLAQAQECYWQKAVLDNLKNGTIAKVSLGVSNLYEEACQLALHSTPTPADALPSIWISHIQVKAHHFAAAAQYRKSLDDLSSSRYGEELSRLNLAAELVKKAMEFSKRNKVFDAVRDDLKGLQDTLTENISRATRDNDLIYLHDVPHPKALPVIQPARMVKGVIPTDLTNGAIPKDALLFSALTPFAVDHACDLWSNRKNYRVREFEQRCAQLDKLQAEALHALGLPGSLQAVDRTSEIPPSLLKKIEELQNDGGLEMLEKLSDEVQLLAFSNENVIDETIDILNQEQDEDEEVRTQQPQLVVPPSSTANTPFLQEVRQLQQTLEAASRSDGIVQEKISASKHDLELLSSDVDYIKTILPKGQSTHSINDENTRKLRGALEQLDDVVDDRRVIVQDVRSIVKRDNIRPKIIKVFQEQQEDKVDMGVFDGLYESEMLKYDQIYQEFESNSNNQESLLSTIRQLYNAFEKRKETDKGYIARQEKLQALDLAYYTYIEIKNNLSEGLQFYNDFSKLAHELKGSVENFLHQRRIEKQVALEKLSKHIESLTLEESRESITNSPLKTFARIPESGTSHQFGAWDESKPIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I1</accession>
    <name>I4Y5I1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960720.1">
        <property type="nucleotide sequence ID" value="XM_006960658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I1"/>
    <dbReference type="STRING" id="671144.I4Y5I1"/>
    <dbReference type="GeneID" id="18475123"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66543"/>
    <dbReference type="eggNOG" id="KOG1994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046724_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5I1"/>
    <dbReference type="OMA" id="DYMNMVI"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="1">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="327" mass="37884" checksum="8BFA68D38E872D5A" modified="2012-09-05" version="1">MDDAFLTQAAEFEKKESKGKHQTYGEMRLQAIKDSEDKNLAGRIASKKQREREKIEEGLERNIIEEAATDDNPVEGSSNKALNMMMKMGFKPGQSLGKRINDDNDDKVDQSNKSIKVDNKTISEPVKPYFLQGRSGIGVQRIVSSKEISEAAAASNALNENQQDFRLRKTYEANARKSEGILKQLRTTIKNADEDLEIKFNVFWINPYDIETYPPFILSEDVQPVQHIYDKQSEAQRLKEQMQNEKLRDEYIDGDEYNDKSIQNIDDVDPEVVQQCKDFLKLDPIIRLKFTQEYAREVHYYCYWCGTKYDSKDDMNENCPGFDEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I7</accession>
    <name>I4Y5I7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_41606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960726.1">
        <property type="nucleotide sequence ID" value="XM_006960664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I7"/>
    <dbReference type="STRING" id="671144.I4Y5I7"/>
    <dbReference type="GeneID" id="18472219"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41606"/>
    <dbReference type="eggNOG" id="ENOG502S4S4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141157_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5I7"/>
    <dbReference type="OMA" id="HRAFMSK"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="83" mass="10153" checksum="59EDB11013B43C18" modified="2012-09-05" version="1">MKEQRYAAIRLYKELHRIGRDYPNPKYEFHRKLRGMFEKNRHLTDPVEIDKKLAFGEYIKKETLSLISLSKYREMKRRYGGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R1</accession>
    <name>I4Y5R1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_61557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960695.1">
        <property type="nucleotide sequence ID" value="XM_006960633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R1"/>
    <dbReference type="FunCoup" id="I4Y5R1">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5R1"/>
    <dbReference type="GeneID" id="18474603"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61557"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5R1"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="252"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="564"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="678"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="838" mass="94645" checksum="8D28270287FF5663" modified="2012-09-05" version="1">MPPKADESLVRLFTSLGLNEAKGVEYAKSKHSKILNESIQEIGLENAKLDEKMATLIASTITVDKQFNGLPLPYKAYIIEKIKNGDLKESNQVTAAVKYLSDKQGDINQDEFNENAGVGIVVPVALIREIAQQSLDPKAKDLPNPWSSHGLLIKSLKEKPELKWSNPLELKNQVDALYTENFGTRDECNKRLKEAAKNAPKPSKESTKKPSQPAVETNIFEQGFLGALHKPGGNPQIKPELRDQHLKATDGKVITRFPPEPNGFLHIGHSKAITVNFGYAANFQGHTYLRYDDTNPEAEEQVYFESILESVRWLGFEPWKITYSSDYFQQLYELAIELIKRGKAYVDHSTGEEMQIQRGGENRGPRVPSPWRERPVEESLQEFENMRLGNYQPGQATLRMKQNIEDGNPQMWDLVAYRVLKAAHHRTGDKWKIYPTYDFTHCLVDSFENISHSLCTTEFVLSRVSYEWLCDALEVYKPRQSEYGRLNMQGTVMSKRKIMKLVKENHVRGWDDPRLYTLIALRRRGVPPSAILSFVKSLGVSTAVSSILTSKFDQSVRDDLESKAPRLMAVIDPIKLVITNVPDDYMVQVKKPFHPKIPEFGEATIPFSKVVYIERSDFRTVDDPNFFRMAPGKLVGLLNAPHPVKCTSFKEENGKVVEITAELVIPNEGEKPTKPKAFIQWVAEHKESNSPVKVNELRIFNQLFKSDNPSAAPDLIADLNPDSEEIIKSAFVDVSLYTLAKNEFQNARKSAYERTSKAKEQTAEIIESEEEKRSPTPKLTAEQLIGNECVRFQALRAGFFALDKDTILNATKEGASAEPHQDDKIVLNRIVSIKAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y605</accession>
    <name>I4Y605_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_34068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960547.1">
        <property type="nucleotide sequence ID" value="XM_006960485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y605"/>
    <dbReference type="FunCoup" id="I4Y605">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y605"/>
    <dbReference type="GeneID" id="18471807"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34068"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y605"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="166" mass="18834" checksum="0C94FC084EAAC761" modified="2012-09-05" version="1">MKELRVEKLVINISVGESGDRLTRAAKVLEQLTGQTPVTSKARYTVRTFGIRRNEKIACHVTVRGPKAEEILERGLKVKEYELKKGNFSETGNFGFGVDEHIDLGIKYDPGIGIFGADFYVVMSRPGYRVAKRKSRTNKIGFQHKVKKEEAQAWFRQRFDGIISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y606</accession>
    <name>I4Y606_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TAFII-31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_49073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960548.1">
        <property type="nucleotide sequence ID" value="XM_006960486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y606"/>
    <dbReference type="FunCoup" id="I4Y606">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y606"/>
    <dbReference type="GeneID" id="18472481"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49073"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y606"/>
    <dbReference type="OMA" id="PHDAQVM"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="14120" checksum="C5BC5139DBDB0DB6" modified="2012-09-05" version="1" fragment="single">MSDVKPVPRTAHLISLILASKGINDAPPATIHMLLDFANRYTHEVLSDSLVYSEYAGRNGYNGVELGDVEMAISVKANHQFSLAPPKEYLLELSQTLNSRPLPPLPESYGPRMPAPRHRLTAPNFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y609</accession>
    <name>I4Y609_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960551.1">
        <property type="nucleotide sequence ID" value="XM_006960489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y609"/>
    <dbReference type="GeneID" id="18475768"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70630"/>
    <dbReference type="HOGENOM" id="CLU_1696874_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y609"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="155" mass="17121" checksum="5B6D96523907A227" modified="2012-09-05" version="1">MLTWCCSGRRNKVKNPDERSRLLDGDRDDDARNLRSTTTSPPTSSYNSPSMNNTPSTGSPNPELSYAYSYPNQEDAASLNNIVSKASEKMVNITNSTSSLKAATSMHSLRDLNSLSTWLESDPIKLDKATEFEQELIKQTANDLSKRRRGEAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y628</accession>
    <name>I4Y628_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960570.1">
        <property type="nucleotide sequence ID" value="XM_006960508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y628"/>
    <dbReference type="FunCoup" id="I4Y628">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y628"/>
    <dbReference type="GeneID" id="18474562"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61493"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y628"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="67"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="458" mass="50231" checksum="F3B5CBDA76C97741" modified="2012-09-05" version="1">MLRVPAVRVAGRRFVQPSKVVSRGLATRSIVNGMSRMNLRSAIAPVALTRAGTTAAGRFYATFQRDKPHLNVGTIGHVDHGKTTLTAAITKHLSEKSGKGQFLDYNQIDKAPEEKARGITISTAHVEYETGNRHYAHVDCPGHADYIKNMITGAAQMDGAIIVVSAADGQMPQTREHLLLAKQVGVKKLVVYINKVDQVDDPEMLELVDMEIRDLLSSYGYDGENTPIVKGSALAALEGRDPEIGTKSIDELMEATDSWLDVPERDLNKPFLMPIEDTFSISGRGTVVTGRVERGTIKKGDEVQILGLGNSFKTTLTGIESFHRELDRGESGDNMGALLRGVKREQIRRGQVIAAVDSIKSYKKFKAQLYILTKEEGGRHSPFFENYRPQLFIRTSDVTVSLTFPEGTAESGEKMVMPGDNVEMVGDLVHDIPLESGSRFTLRESSKTIGTGIVTEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y650</accession>
    <name>I4Y650_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_34013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960474.1">
        <property type="nucleotide sequence ID" value="XM_006960412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y650"/>
    <dbReference type="STRING" id="671144.I4Y650"/>
    <dbReference type="GeneID" id="18471791"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34013"/>
    <dbReference type="eggNOG" id="ENOG502RZZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082172_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y650"/>
    <dbReference type="OMA" id="APWEEYA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31844" checksum="078E946DC70836A0" modified="2012-09-05" version="1">MKTSVTHPLNISIIIPLDCIDYMSSIIKPSLTIVDNPINLDYLSSLCYKFHHDINSLTTDDLTYYNKLYSFNQNKSPHLFRFGNLLMSSAPGKKLRLNQQHEPEGQSDLKSPVYRDLHLDFIRIKKSGCNVIACCLDDNELISLGISWSEYKETATKIGLSILRFPMPEGLHPPDLNEFHDRLSILLNDFTFKGFNILVHCRGGVGRAGIIASAWILKMGLIPNLLLPAINNETEHCLSILKSLINVVRLRRSLKAIETFEQVRFIFNFIVFLRKRAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y674</accession>
    <name>I4Y674_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_30369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960498.1">
        <property type="nucleotide sequence ID" value="XM_006960436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y674"/>
    <dbReference type="FunCoup" id="I4Y674">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y674"/>
    <dbReference type="GeneID" id="18471146"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30369"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y674"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="145" mass="15430" checksum="52937373E1067522" modified="2012-09-05" version="1">MSDAPTITIGHKAHRPTTARTQGEINANARAGGTAGDRKMGQANKGHQGTDHQRIAKLDRENEVAPPPKISLSVGKAIMQGRQATGLTQKDLATRISEKPSVIQEYESSKATPNPQILGKLERILKIKLRGKDIGAPLGGPKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D8</accession>
    <name>I4Y6D8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature viability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960453.1">
        <property type="nucleotide sequence ID" value="XM_006960391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D8"/>
    <dbReference type="FunCoup" id="I4Y6D8">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6D8"/>
    <dbReference type="GeneID" id="18473052"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58696"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D8"/>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="67857" checksum="68ABA27DBE4020F5" modified="2012-09-05" version="1">MAPVSIFKKPGAQKFQLVHKSQSDKDRDPNDDKGVLKQIDKKTVKPGDAANFGIYYDDREYDYTQHLRTIGGQDAFGQELDSVLITAPDPKAEKKSFILRQQQEKDAQDEAIKRAYENQASIPLELQGFNPDMDPALRQTLEALDDEAYLEDLNEEELDEEDDDNEWFDDLLGDGLRGKDEVIDFGPDEEEDPAITARKERERQEYETAKANGEDLSQFHTEDWMQKFREFKLASKDQPSPPASDDLPSDEDEFEEMSDYHSEGADTVGSLRTGIGAARTRRKLRKAGSDASGYSMSSSSMFRNDGLQSLDAQFDRIEEEYNSEEDEDEEEDEEEGFDPTSDLNVHSREDFDSILDEFLDKYEVVGGRVQQKLEGDTPAEKLQTMRLAMADLAPKGDQIKKYEDAASKRITSAYRIATGEEEDDNSNIPMPFDVDAKEDRMDAQTILTTYTNTENHPTKIRSQDLLSGRKKEKKEGPVRHVAFAEKEDVAPVRKVQIVVDPKTGFPMEIGEDGEVEDEESEEEEEAARRPKKQTVSRNRNESKEEKKARKQAAKTDKQNRKVEKKETKEAFANERKSQISKTANAKQSQDVTASMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6L2</accession>
    <name>I4Y6L2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_22174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960402.1">
        <property type="nucleotide sequence ID" value="XM_006960340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6L2"/>
    <dbReference type="STRING" id="671144.I4Y6L2"/>
    <dbReference type="GeneID" id="18470914"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22174"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y6L2"/>
    <dbReference type="OMA" id="RYWDASD"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697439" description="Trehalase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="729" mass="81317" checksum="C516D720BB1FBDF5" modified="2012-09-05" version="1">MVRKLSVALLALSGVLNAQQSNSQSATATVSHIPLSTASPSPALPTDTNIPGDDEEVYPQPWCSSPIYCSGDLLQSVALAELYEDGKTFIDKPTKFSQAQVLDAWSKVNDGDQENATVGQIEQFVQENFGPEGSELVEVLLQNFDTNPEFLNNINDDLVKGFVGTIHSYWSQLIRQVNTTATCDNDSCDTTLLELPDTFVVPGGRFRELYYWDTYFTFLGMLNSGLSEQVRETLNNFIHAIDTYGFIPNGFRSYYLNRSQPPFFALMVEDYVNWTNDTGFLDIALPAIEKELVWWKNNRTTEVKSPWTGKSHNVAKYNVANTAPRPESYLADFEVTNKDVEYTEEEKQELYAELSSAAESGWDFSSRWSKSPRASQGLDDQNPVLRQLNIRQLVPVDLNSILYKVHTAAASLYAISSDSNQEQIDAHNKRAEEIKEAILDLNWDNDQESLIFKDFNTTASDYSSTWSLASYFPYWAGIIPDSVSSSVDTAQSAFAGLRYTLDRFNGSLPTTIIDSGLQWDLNAWAPLQYITIKALEALPDNVTTQALRRPEEGQSTFSLVPSKQLGMDDESQVPIQPLYNISGSTSSKNGFTNEYEGNNWRDTLANEAVQRFISSSFCSWYSTGGSIPNMLDQLPAEKLALYDADSSYTGYMFEKYNSTNLVAAGGGGEYEVVVGFGMSNGVLIDLGSRYGDKLSKPQCPDIEITERQLPRRQIGPLYSGRRTLNYVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6L6</accession>
    <name>I4Y6L6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_10709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960343.1">
        <property type="nucleotide sequence ID" value="XM_006960281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6L6"/>
    <dbReference type="STRING" id="671144.I4Y6L6"/>
    <dbReference type="GeneID" id="18470585"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_10709"/>
    <dbReference type="eggNOG" id="ENOG502RJAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1013969_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6L6"/>
    <dbReference type="OMA" id="YIASMHW"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="32458" checksum="0C24A1AC0ADBAB26" modified="2012-09-05" version="1" fragment="single">QLSDYLGHDKVYLSIYESNSKDNTKVLLQEFNKSLNDLGISHTVITDQSTVKPTLVGNERIGYLAGVRNKTLEPLTKELDEKFKKFKKIVFFNDVFFDWFSVVRLLNTRNGDYDQVCAFDYFKIGVYDTWVTRDTCQRRVKPVWPHFQDKHSINLLRQDKPIPVNSCWNGLTAFDSKWFVEGRQEDITPVRFRILDECVASECLMSSYDIHLQSDKQPDIYMNPQVPTAYERPVFQLRARLVNLSLTRPYLTYRYWFEERLFGWLTAIGRKEETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6V6</accession>
    <name>I4Y6V6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_52591</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960206.1">
        <property type="nucleotide sequence ID" value="XM_006960144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6V6"/>
    <dbReference type="FunCoup" id="I4Y6V6">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6V6"/>
    <dbReference type="GeneID" id="18472588"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52591"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="I4Y6V6"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="14"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="35249" checksum="539881F729D7C962" modified="2012-09-05" version="1">MRLAPRAITYTRNGQPADVLKVKTLNALPNLQSNDVKVKFLLSPLNPADINVIQGVYPAKARTITIDNEEYRLGGNEALAQVTEIGESVKDLSINDWVVMGASQSGTWRSSAVLPSKDLIKVESNALSKVHGATLSINPPTALRMLEDFVNLKSGDYIIQNGSNSAVGTAVIQIAKAMNIHTINLIRERETTEKTNQLVTELKNLGATHVLTNEEISQNSKQARESIKSWTQGKELKLALNCVGGKETTEIVKTLSEGAYLVTYGAMSKQPLTIPPGLHIFKNLQSVGFWMSRWYKDHTMDEKKTLISEIVKLIENGNVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6W8</accession>
    <name>I4Y6W8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_48626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960218.1">
        <property type="nucleotide sequence ID" value="XM_006960156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6W8"/>
    <dbReference type="STRING" id="671144.I4Y6W8"/>
    <dbReference type="GeneID" id="18472460"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48626"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375614_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6W8"/>
    <dbReference type="OMA" id="TEITFHA"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="445"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="664" mass="74254" checksum="AB29DC24784A55B7" modified="2012-09-05" version="1" fragment="single">MSEPQQLKNRLEAKRIEHELEREHQRKVFELEMKRLEDEHKKEEQQLLSSSSCPSSPPPGKHLLPSFIDSRRYSDEFDFEDDDKFPVLIKDIDGKFNTKLSISRPPSTNSKYYDLDFNIPNNPPYPLTSPNPPVNANSRRSLTPNQSQQKTAASQSQPQSQAQSNQKVDHDLNRFIGVKLEDIKGEIYSLCKDQHGCRYLQKKLEDDDAVDEVVDGVQLTSRQLIFNQIYTHFSELMTDPFGNYLCQKMLEFANDQQRDTLCETVSPELVTISLNMHGTRAVQKMIDYLSTRRQINTIIMSLSLNVVTLIKDLNGNHVIQKCLNRLIPNDNQFIYNAVASNCIEVATHRHGCCVLQRCIDHASDQQRIQLVTEITYHALTLIQDPFGNYVVQYVLDLNDNRFSDGVVRQFLGHICALSVQKFSSNVIEKCIRVADASTRSSVIDELNHRPRLEKLLRDAFGNYVVQTALDFAEPVQRIALVEAIRPILPMIRNTPYGKRIQSKLQRASMFIRDSSDPTFGLRPAGPTGVGNPGGFRSASASNFGGSPSPSLLGMGRSVSSHGLDYQSLSTPFLGVDNQSNTALAAAAHHQHAQQLAALANVNVNPAGPVNGDSRLVHPISLRNPVNLGTINAAAANVQAHQHAPQGQPGFDYFFSAAQHPSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X4</accession>
    <name>I4Y6X4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960224.1">
        <property type="nucleotide sequence ID" value="XM_006960162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X4"/>
    <dbReference type="GeneID" id="18475082"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66071"/>
    <dbReference type="HOGENOM" id="CLU_497154_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6X4"/>
    <dbReference type="OMA" id="DQREDEW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="512" mass="58048" checksum="08B510774E0E6B5F" modified="2012-09-05" version="1">MNKSTKSNYKPLTSTGWIKSGALESSSQSSRPTSSENRVSLTRHKSSPPQLESKQNSAWMLDKDSFSKAMKSTKTKLFSKPSESDTKGKKARTKSKIYWDPEEYYKNKDKKEKAKVEKELARQYEEDLEVMPSQSHHDHEIDLPSSPSSLAKELTTDKALSQLARMRKAAGLSPVDEEKRAKDRMTALRERRVDLEMRKAMIANNDANGNYNGHINDNLQAHLTTLANFSKRLNEVTIPSLKSNKNIETNKRRKYTQDDSNLRRPTRLPTIDDLEADQYEDELLFTQNNNNGAYRTFSQILTEKTPQKDKSQDKILVLGTPSPLSKTKLHQTKLKQPTPVRYSQNEPVSNIPVGAIGFPELEQAWEGTRPIVEESSTSKKRKKDKEKDKSQQSLISGWVSQVSGLSEEVPKRKLWSGLDMDSSDRPDVSFDLDSDYDDEDSVLLDLETPQRNRITKSLPLDFLRNDSPSSERAVATIVSPSHSRSQQSSGNILPTPHSNIPGLHQLMRNNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y732</accession>
    <name>I4Y732_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960109.1">
        <property type="nucleotide sequence ID" value="XM_006960047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y732"/>
    <dbReference type="FunCoup" id="I4Y732">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y732"/>
    <dbReference type="GeneID" id="18474435"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61278"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_0_3_1"/>
    <dbReference type="InParanoid" id="I4Y732"/>
    <dbReference type="OMA" id="RMDLGMT"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="19231" checksum="0EDDB1C6B26FC2D6" modified="2012-09-05" version="1">MSSFSSTPPKMLALYLSLPIITFGLGYLLGKPAKLSTKSDFTDESDDEDDQTGLDTVKPGILEPCKLVLVVRTDLGMTKGKIAAQCSHATLACYKALQQSNPTLLRHWERTGQAKITVQAKSEEELLILQAQAQSLNVCARSIQDAGRTQIEAGSTTVLGIGPAPVDLVNMVTSNQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y733</accession>
    <name>I4Y733_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L37ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960110.1">
        <property type="nucleotide sequence ID" value="XM_006960048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y733"/>
    <dbReference type="FunCoup" id="I4Y733">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y733"/>
    <dbReference type="GeneID" id="18474436"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61279"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y733"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="92" mass="10235" checksum="277AB18F2DCFF6EF" modified="2012-09-05" version="1">MVKRTRKVGITGKYGVRYGASLRKQVKKMEISQHARYTCTFCGKDSVKRTATGIWNCKACRKVIAGGAYTLATPAATTVRSTIRRLRDVHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y739</accession>
    <name>I4Y739_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960115.1">
        <property type="nucleotide sequence ID" value="XM_006960053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y739"/>
    <dbReference type="FunCoup" id="I4Y739">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y739"/>
    <dbReference type="GeneID" id="18474437"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61280"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y739"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24367" checksum="10E2C96C264487B4" modified="2012-09-05" version="1">MAIDLKQLDQHLAKNSYVDAYNVSQADVFVYNQLGSAPSSEYQNVTRWYNHISSFKNEFATLGGGAFAASLYGSVEGSTAPAAAAAAAPAAEKADDDEIDLFGSDEEEDPEAERIKAERVAAYNEKKSKKPKAVQKSVVTFDVKPWDNETDMKQLEENMRALEIDGLTWGLSKLVPVGYGVNKLQVTLVVEDDKVSLEELQEQVEADEDHVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C6</accession>
    <name>I4Y7C6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960010.1">
        <property type="nucleotide sequence ID" value="XM_006959948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C6"/>
    <dbReference type="FunCoup" id="I4Y7C6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7C6"/>
    <dbReference type="GeneID" id="18474405"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61229"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018582_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7C6"/>
    <dbReference type="OMA" id="QVHEENA"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="291"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="601" mass="67152" checksum="3B04292CD3214211" modified="2012-09-05" version="1">MAESTKSSKSKLLAQKQSSPSELVPSDILLDRFNAWKTITKNLIAYFEGIADIESNTARELTKLGGVIQVPFKEGSQFMGHGGLQDIFFEVRDKSRSIADHHANLAKTIDGSIVQHLHKLRAEIKAHIRNIANDTSKLATSVAREREYSMRTVSDLQKAITTTKNTPTSITAREDPYLMNSLVAKQLQKQVQEENALQKSIIIMQQNSAQFEEGITSSLQSAWSTFDEWQSRMSFDVQESWKGMGQMFSALEPDAEWLAFADRTDHLLDPETPLRQQELIDYPGRDDPSVLAVHVGWLERKKRFTKSYKEGFYVLTPAGYLHEFNTPDPTSQSTPTLSLFLPNCTLGPPSHSNTAKSHKFHLEANKANKFSRDHSYTFRARSHETMSEWWNDLRMLVSRYLVASETMDRSGPIAAAVRSAGYISESEEEGGSSLEEDEEEEEEEETFSETYENQPTEAEQAQLQKAKEDEEQAKVNLDHEPESEEEEEEEEGEEEEEAAPAYSSPRESSGIQIGKDGYAVDKKPSIKVGRKSSKRSSKGNKPAKLVTGDLDKKESAEPDTGGSPGLLNKFKEAFVKSTDHSAEPQAEKVDVAAPTQTATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V5</accession>
    <name>I4Y7V5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_21377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959976.1">
        <property type="nucleotide sequence ID" value="XM_006959914.1"/>
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        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V5"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
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        <property type="entry name" value="Csn12-like"/>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="63"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="264" mass="30240" checksum="F6DB3015F81BDD68" modified="2012-09-05" version="1">MTDKQRRSSGKESKRWGVYYIIGLVFKTYFEINTLSLCKNILRAVGAMKDLMPLEAYPKAHQVTFKYYTGVLAFLDDRFDKANEDLTFALQKCPVQSRKNQALILTHLIPLRLLQGDLPSQDLLARFPHLEELYRPFVEALKDGNVKHFDEALVRGEKRLVENGTYGIVERVRELCLRGLFKKVWSLNGQQKIIEITKFKRALSVSGVNIDNEEVECLLAGMIFKGYMKGYIAHAQQKVVLSDVLNGKAHPFPNVKTVNVQFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y819</accession>
    <name>I4Y819_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959832.1">
        <property type="nucleotide sequence ID" value="XM_006959770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y819"/>
    <dbReference type="GeneID" id="18475684"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70080"/>
    <dbReference type="HOGENOM" id="CLU_2265796_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y819"/>
    <dbReference type="OMA" id="MEPWERM"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="103" mass="11628" checksum="DDA8387C35A999B0" modified="2012-09-05" version="1">MPTNKVNAPNANSYSFLLWKMRLGMESTWGFAILEPWETALIMSIVIAVASIILFSVLFYAPAQLLRLKSRLAYYLFGSESSQKETIAVLNEWHNVIRGVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y826</accession>
    <name>I4Y826_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PROCN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_65699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959839.1">
        <property type="nucleotide sequence ID" value="XM_006959777.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y826">
        <property type="interactions" value="942"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y826"/>
    <dbReference type="GeneID" id="18475049"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65699"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y826"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2110"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2341" mass="270431" checksum="03BD93831FB31364" modified="2012-09-05" version="1">MSNGPPPGFGSHTSVLSPEDLSVKVKKHHQFSKRRWGLKKPGSAGTSGSEKVELPPEHLRKIIKDHGDMSHMRFRNEKRIHLGALKYVPHAVLKLLENIPMPWEQVHEVPVLYHITGAITFVNQIPRVIEPVYHAQWASMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYSDNILDVEPLESIQLPLDEEEDAPIIDWFYDPKPLEDTVHINGPSYKQWSLDLPQMANLYRIGKTLLSETHDRKNASYLFEDKAFFTSKALNMAIPGGPKFEPLYKDDVDDEDWNEFNDINKVIIRQPIRTEYKIAFPHLYNSRPRAVQIGPYHAPQSQYIRTEDPDMPAFYFDPSINPISSRAVAGAANTPQVSHEDQVFGYGEDEDDDFEMPEDMTAFLEDKPVYSDNTSDAIALWWAPAPYNTRSGVTRRAQDVPLVKDWYMEHCPPGMPVKVRVSYQKLLKVYVLNRLHQRPPKPQNKKRLMQSLKGTKFFQTTTIDWVEAGLQVVRQGYNMLNLLIHRKNLNYLHLDYNMNLKPVKTLTTKERKKSRFGNAFHLLREILRLTKLIVDVHVQFRLGLCDAFQLADGLQYSFAHVGQLTGMYRYKYKIMRQIRMCKDLKHLIYYRFNTGPVGKGPGVGFWAPGWRVWLFFLRGIVPLLERWLGNLLARQFEGRNSRGVAKNVTKQRVESHYDLELRAAVMHDILDMMPESLKQNKAKTILQHLSEAWRCWKANIPWKVPGMPTAIENIILRYVKNKADWWTSVAHYNRERIRRGATVDKAVVKKNLGRLTRLYLKQEQERQHGYLKDGPYISSEEAVALYTSTVHWLESRKFSPIPFPPLSYKHDTKILVLALERLKEAYSVQGRLNQSQREELALIEQAYDNPHECLSRIKRLLLTQRAFKEAGIEFFDTYDKLIPCYDIEPVEKITDAYLDQFLFFEADKRGLFPSWVKPADTEPPPLLTYKWAQGINNLHDVWETSEGECVVMMETQLSRVYEKIDLTLLNRLLRLIMDHNLADYITAKNNTPLTYKDMSHVNSYGLIRGLQFSAFVFQFYGLVLDLLILGLNRASEMAGPPQSPNNFLQYKDTATEVGHPVRLYSRYVDKIHMLFKFDADQSRDLIQRYLSANPDPTNSNIIGYNNKKCWPRDCRMRLIKHDVNLGRAVFWNVKNSLPRSLTTIEWEDTFASVYSKDNPQLLFSMHGFELRILPKIRAQNSEQYRLNDGVWNLTNEATKERTAQAYLRVSDDGINAFNNRIRQVLMSSGSTTFSKIINKWNTTIIGLMTYYREAVLHTNELLDSLVKAENKVQTRVKIGLNSKMPSRFPPVVFYSPKELGGLGMLSMGHVLIPQSDLRWSKQTDTGITHFRSGMTHEDDQLIPNLYRYIQPWEAEFVDSARVWSEYAMKRKEAMSQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDWKQYQLLKHNPFWWTSQRHDGKLWQLNNYRVDVIAALGGVESILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEALQIETVQKETIHPRKSYKMNSSCADILLFSAYKWNIARPSLLNDSKDVLDGTTSNKFWVDVQLRFGDFDSHDIERYTRAKFLDYTSDPSSMYPSPTGCMVGLDLAYNLYTAYGNWFPGLKPLMQQAMAKVMKANPALYVLRERIRKSLQLYSSEPTEPYLNSQNYSELFSNQTIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKLEKFGDLILRATQPQMVLFSLYDDWLKEISSYTAFSRLILILRGLHVNNEKAKIILRPDKNTLTEPHHIWPSLSAEDWIKVESQLRDLIVNDFGKRNSVNTASLTQSEIRDIILGMEISAPSIQRQQMAEVENSAADANQITALQTKTTNVHGDEIQVVTTTNYENQQFASKSDWRARAISSTNLPLRVQHVFVSNDDVKDDSSAFTYVIPKNILRQFIISGDLRTQVAGFMYGVSPPDAPQIKEIKAIAWVPQRGSFNNVELPSNLPEHDYLLNDLEPLGWIKTQSLELNHLSPQDVTTQARVMANNPIWGPSSICLVCSFTPGSVSLSAYSLTVNGFEWGRKNQDLGGQPAGFNPSFSERTQLLLSDRILGMTLVPEGGIWNYALSLSQQWTPTLPYQMALARPTSFWADIHRPLQFSNFTEMSSGADADVENSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8B5</accession>
    <name>I4Y8B5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">WALSEDRAFT_47856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959695.1">
        <property type="nucleotide sequence ID" value="XM_006959633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8B5"/>
    <dbReference type="FunCoup" id="I4Y8B5">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8B5"/>
    <dbReference type="GeneID" id="18472432"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47856"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090154_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8B5"/>
    <dbReference type="OMA" id="WYMDESQ"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="175" mass="20195" checksum="EE5F7CDD2D8CC0AA" modified="2012-09-05" version="1">MRAWYMDDIEGSFTAPHDSGVSVNADYLAKLGIQYTLNPDIEKVAIEQGYKNRDEVGISREALGDEEYKNKLNIFKVEHLHTDIEARLILDGSGYFDVRDRLNNNEKWIRIAVEKGDLIILPPGIFHRFTTDDNGYTRAMRLFTDEPKWQPYNRSNEVEKDPSHLDYLKSIGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E1</accession>
    <name>I4Y8E1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_65587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959721.1">
        <property type="nucleotide sequence ID" value="XM_006959659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E1"/>
    <dbReference type="FunCoup" id="I4Y8E1">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8E1"/>
    <dbReference type="GeneID" id="18475035"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65587"/>
    <dbReference type="eggNOG" id="KOG3984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y8E1"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="325" mass="35199" checksum="F6A2D9E91ADAE24A" modified="2012-09-05" version="1">MITDIENAVKVIKSIVPENLRHPVIGIVCGSGLGTLADDLDQRFELEYNRIPGFAESGVSGHKSKLAFGFLGKETKVPVVCMLGRFHMYEGWSSTQVVFPIRTMAHMGIESIIITNAAGSLNPQIPTGSIVTIHDHIAFPGLSSDNPLKGPLVPIQTEALKRLNPQPPQPPRFLPQSDAHSFDLRLLAHRAAHKIGIARDAIVEGVYCWVTGPTYETPAEGRLLRQAGADVVGMSTIPEVIAAHHAGVKVLVLSLVTNFVVIPDTYPSAKAIVDAEINGTAPPVYKPSEIVSHVEVLEEGQKRAQDMRRLVSEIIESRATAEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8F8</accession>
    <name>I4Y8F8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_33485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959738.1">
        <property type="nucleotide sequence ID" value="XM_006959676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8F8"/>
    <dbReference type="STRING" id="671144.I4Y8F8"/>
    <dbReference type="GeneID" id="18471692"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33485"/>
    <dbReference type="eggNOG" id="ENOG502R9X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076691_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8F8"/>
    <dbReference type="OMA" id="TEITSDW"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="34664" checksum="04D1EDADE7BBC0FC" modified="2012-09-05" version="1">MSSTILIVGATGNTGKGLARTLPELLKNEGGNYRVVALTRSLSSPGAMKISQIGGIEVVEKDWTTIDAEWLKENHVEKAYVAAQNMVQQFTEESKLYLAMLEAGVKYLVRVSTFVHFINPASPVYYGRIHWALETMLSQPEFDSLNWTSLQPNYFGGFISVDAINWIKKHRETGDAGVLNVVFDKDAPVAAIDAEEVGIVAAHLLAADDYKKYNKGKYILNGPEDTNGQKLVEAVERLAGTRVKEVQYNYKDFIDRLPAFGIPENILASMFAGIKLMWSGKGSTSESTTSKEIAELYRPKNTIYDNLKNVLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I4</accession>
    <name>I4Y8I4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959764.1">
        <property type="nucleotide sequence ID" value="XM_006959702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I4"/>
    <dbReference type="GeneID" id="18474325"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61085"/>
    <dbReference type="HOGENOM" id="CLU_1066342_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8I4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697625" evidence="1">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="261" mass="27006" checksum="6AB9422A9A9061D3" modified="2012-09-05" version="1">MFNKLIVAAIAACSVSVSAAPVAKMGDDAFVIKRQDALLSPVAQALGGVKSVAGMKRDGAVEQVTDKLAEPLDSTTTGWLKRQNTLEEILSGLESNQDLQGALSAVQSQSQSQGISPQSVEPEIGKIVEVLKSTTSSIQSADTNSDHSALGLLVSGQLYNIVQKLSPLLDKLGEGLGLEDVIKPLDAELLGLIKSLEPAVANIEQIVGGLLSDLGLGPLGDLLHNALERGVPTLLAGLDHTVLSKLNDVPVVGSLLEGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R6</accession>
    <name>I4Y8R6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_29696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
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            <taxon>Wallemiomycetes</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
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                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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    </evidence>
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</entry>
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                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
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                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="321" mass="35922" checksum="052D16AE3FFC38AC" modified="2012-09-05" version="1">MNEEVHKRVKKYAQEVLVIVRPPPHISNNPMNLQIQLVTPKSNRQSMASDSNLSRSSSLHSSHSLGQASNLSLHSTTSQSQFTAGGRKLIPLYNLQYHNVLTTAITDAGTDAKIAKFTKRGLEILNLIGLESDLLSSDNASTTSKKFTLDGLFKFGKNDSKAPSELLNHDEYSWLIRKLLKSSETLEVTADDLQFTWKKSSESNINSRRSSIPSQPASEISHPPSEIDREDDETPWSFYAISKHFNKIHLGTLHPAPHHPRIVGQLKVPFPLPDIPVPNTNQKLSPEDLKDILSCTCLWLVTKEEFGGLDKRRKGDGWRIT</sequence>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
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                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
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                <person name="Grigoriev I.V."/>
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        </source>
    </evidence>
    <sequence length="937" mass="104992" checksum="136E92C03BD93C7D" modified="2012-09-05" version="1">MKLKNKYTIRLILTRSGKDLVLVNSAEDFEKAKKKSRGYLKCKFRFELEDNQPSTPIQSTSQPRLTTTAKKRLSLNPSFINEAEDPTSPLTKQSRRVLQPRSAIMSKTVETYPDIQDYFAAFVKDTIHDYFNNTLHSNTQSEQSSVASNRNSKPGTLSAMRSTVIYDSDISEAHTNKGNPPIRLHRETTPSEVDQLQSSPHFVEHKEQALQQPRLEGLQEVNEDTMEVASEEDRPGDKEKYKRVEEEQEYGREERQKEPEPIEEQLEEQLEEQIEGQDEGHEGKSEDKHENDGVRSSPIEQFDDDITLTGSQIPPSAQPQLSSPILAPEQGLETVVTPVHPNEEIKQDQQESQQDGQRESQEQEQQEQQDTRQGDLEMQQPEEYVPADTESLPSPFKRPSPVKKDRPANNKNEDILDEELDLAKLFGSSTQGSGRPRRSIQAVLGDEKDDEHNELLMEEEANDEDEVMTDYESDDTIDRERERAKLSKSTQSTRRGSSDDNFEADDDEEPGEDKDKREPAMEAPPVVHSTSQFYIPDSPTASERAVSAQINAHDSLSISVNQSFSRQGDTSLLQNQEDDNEAENGEHQQYIGSEILPPQVHDEQSDSRDAKSEDFLQDEKLAEGEGEEDQPERTPQRDNGETSSIPQSKLSPQPMIESGSTPDLNQTQLSTVSNDTKDRLYQEALGTDNTKDKDAQDTTKDANEGVEATPAVEASKSQDVEKSSNESTDLEKPKPALGKRSREEAPSDEDESIQETKRTKYNDDKVSKEPKGRARHSEGGIYHAQRKIAMPPRLSINFDDLIKQTSKGPRSSSSFLPLSELKKDKSRYAIESPMASPRASPAVESRPRPSVKRVATSDNNDNSSSSDSDNDDSSSDEEEAKRPRRKSAIPAANPRLNQLNRGVDRRASAIPAERRAGASTPGRVTRSRVKAGGLADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y956</accession>
    <name>I4Y956_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_39936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959524.1">
        <property type="nucleotide sequence ID" value="XM_006959462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y956"/>
    <dbReference type="STRING" id="671144.I4Y956"/>
    <dbReference type="GeneID" id="18472144"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39936"/>
    <dbReference type="eggNOG" id="ENOG502S52G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100674_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y956"/>
    <dbReference type="OMA" id="VYRYYPD"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="16713" checksum="80326C665EBC573B" modified="2012-09-05" version="1">MINLVARRNLKNISKSLSVRTYATRPSSATTGDEVDPQLGGYPQFVPQKAIERSPFNKYWDQQGRANFGDTLHEDEDVLGIHAPDVHQYSYAESAKSILYTALAFAAFGYVASGLVPERNVAPRDYPRDGLKEELSGLEENKANEYTEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y970</accession>
    <name>I4Y970_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959538.1">
        <property type="nucleotide sequence ID" value="XM_006959476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y970"/>
    <dbReference type="STRING" id="671144.I4Y970"/>
    <dbReference type="GeneID" id="18474272"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60988"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022390_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y970"/>
    <dbReference type="OMA" id="YISASVH"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54901" checksum="D9A107311B686A67" modified="2012-09-05" version="1">MRTMEQNIQRAEGELARRKDAFKTSLIGLSNSLIEIVEPLPEASNSEDEAIVAFEESFYPQLPKLIETEDENIIDILVETLNPTDSLLEHTESLRAGLEDEKIRREEEIQTVYDQLNPLWDKLDVDESQREQFINTNMGSTLGVIEAYHQELDRMLELKRENMALFVQRIRGDIEKLWDYMQVGSNERSQFTAFTDDSFNDECLAEHENILAVLQEEKNTKGKILTKVHLYNQIVSEEIQLQESANDASRLLGRGPRDPGRLIREEKMRKRVAKKSQIEADLLEMLESWENENARMFLINDEHFAETLKQRIASKAQEKENKRKGKGGGPPPVTRKASNSSLNGSTNSTTTTNKRKPLHAPQESITPAPSAKRMRVGSAESNKGVVNSITKSTHSHNSAIKPKRMVNKQAPPRYPIALSSVAESPANGHDPFGKPAQAQARSKTMPSKKSRRSSFKPETRVASVSSVIDHQYAELEAIAAGEEEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9G1</accession>
    <name>I4Y9G1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959392.1">
        <property type="nucleotide sequence ID" value="XM_006959330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9G1"/>
    <dbReference type="FunCoup" id="I4Y9G1">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9G1"/>
    <dbReference type="GeneID" id="18475004"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65274"/>
    <dbReference type="eggNOG" id="KOG2973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037769_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y9G1"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="44679" checksum="BC238ABA1D4BB813" modified="2012-09-05" version="1">MSEFKELVTFLRNENPTIRQIAIQNLAGFSTTQKQLFDNQSIQEVKLSCRDKPAIAHDAFSILVNISDSVLTSNAIVTNDFMVFLTSYIANPTALLADLACMLLSNLSKLPNVIHTICSQQIPVSLNNGEPSFIASKSESSTVQIEGQQTSFRAVPCLVEAFVQGANKPETAVESAEAQAKRKSNCHFLGSVFANITTTQPGREYFTSPSPSFEALANQTSDKEYPLAKLTAFTEHPNNIRRHGVASTIKNSTFVKDAHRALLAEDKEIIGGCSGVNMLPYVLLPLCGPEEFDIDEQEALPEVCQLLPETKKREIDPSVRKTHIETLLLLCTTLHGREYLRSRNTYVVIKAAHAEEKDQQVIDEMIKLVNLIMRQEGEETKIQELSAKESEMVDEDMMIEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N9</accession>
    <name>I4Y9N9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LUC7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959214.1">
        <property type="nucleotide sequence ID" value="XM_006959152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N9"/>
    <dbReference type="FunCoup" id="I4Y9N9">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9N9"/>
    <dbReference type="GeneID" id="18474169"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60797"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030397_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y9N9"/>
    <dbReference type="OMA" id="CPYDLFQ"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="38027" checksum="0846ABB6FDBD4310" modified="2012-09-05" version="1" fragment="single">MGKIAEVQRKLLQQLMGAEAMGFKSVNLHFTDQQVCRNFLCGLCPHDLFSNTKMDLGPCPKSHSDKLKKEFLEDQLKNASKYAEFHREYENNIRNFLTECDRRIRTAHKRLEKTPEENNKTTALMREVGEIQAAMDQAMIDVEKLGESGLVEESMKELQKVEALKQEKINKEQELTDLTETSGASGHQKLRVCDICGAYLSILDSDRRLADHFGGKMHLGYFELRRIIAEISENRAIQRRKQQEEADQDREYKSQQPERDQQTDDINISSSLYEDKDAPSKLSPPPGEQIDPRARRQDEREARRDARRAERRGSFRNRSRSPTARERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U8</accession>
    <name>I4Y9U8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_69656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959270.1">
        <property type="nucleotide sequence ID" value="XM_006959208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U8"/>
    <dbReference type="FunCoup" id="I4Y9U8">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9U8"/>
    <dbReference type="GeneID" id="18475620"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69656"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9U8"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="824"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="324"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121570" checksum="51DC2EEE8B998299" modified="2012-09-05" version="1">MSRVRQRGYDFETQPEETYGFHQPSRPVDRDKAEAELALNIKKATNTDETAPKQKHVRKCIVYTWDYHSSQSIWSGLRVQPVMSDEVQTYKALIVVHKIIQEGHPITLKEVQQHVNWLDTCSRTVGNFGLGYAPLIQAYVQFIMSKLRFHRHHQEFNGLFEYAEYITLKGVDDPNEGYETVADLMNLQDGIDSFQRLVFMHLRGISNNECRISSLVPLVKESYGIYRFITSMLRAMHRRVDNADEVLQPLVQRYNGQHHQLRKFYYECSNLKYLTSLINVPKLGQDPPNLWQDPEGHAAMAERKAAQKSPAPPPAAPATPSVDIAEQARMLKEYEDQQAKLQAERDAQEAQRQAMMVQQQREFEEQQMLQQQQQEMARQQLLQQQAAQQHMGVAAEMERQLLEMRGQFERDQIMLQQYDQRVKALETELAAINANVGAQMIGKDELIKSLQDQITMWRNKYEALAKLYSQLRTEHLDMLGKFKQMQLKANSAQEAITKYEKMERDVKAKNLELADMIRERDRARFDLDRLKSSQKDELSRLRRDLDFANERAEDATRHRSTETSSMISRYNRQLNELEDSLHVKQTQIDELLHKLDIANGEADRVREEKDQEIAIIQEGMDSTINKLGEMQLTQGESDQALNAQIDLLIVDHDKKLKQIIDSILQACVHKIDDVNYELESSIQTGNQNATPEYTLSMIEKAQSVASEFAVTFTSFIAPKQTAGHVDVIKIANDLSQTICEILLNAKGVSRLAKDDEASDALIKGARKVGDVAARVFLDVQSFRLALVPSEQRALVVARKNSDCRESLNELSDILDSAIPKGRTELSKANGEIGDIVEKEMLAAANAIQAATERIQAMMQADISSRYSGLDKNVHDSILEASLAITNAIARLIQAATESQKEIVAQGRGSTMSAQQFYKRNNRWTEGLISAAKAVAFATNLLIEAADGVLNGSHSLEQLIVASNEVAAATAQLVAASRVKANFMSKTQERLEIAAKAVTEACKALVRQVKAISAKQAQDADANIDWAQVPTHEFKVREMEQQVEILKLEKDLSSARRTLGAMRRAGYRNEDDDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA39</accession>
    <name>I4YA39_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959093.1">
        <property type="nucleotide sequence ID" value="XM_006959031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA39"/>
    <dbReference type="GeneID" id="18474124"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60724"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="InParanoid" id="I4YA39"/>
    <dbReference type="OMA" id="HERWNTI"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="31"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="492" mass="54911" checksum="7329CCC9128E4CB0" modified="2012-09-05" version="1">MPKEDGDVIWVTLEEHENPYKWSKPRKYFTTLALCGFSFLVSGASSGYAAPGAESDLVDKLNTSSTLFELGLGIYVIGYALGPLFLAPFSEIVGRYKVYVVSYFVFMCMFITISLSPTITGVVLGRLISGLAASTGSTLVGGSIADIFDDGSRGIPMSLFSMSALQGAGIFPLCFSWMMDKGLGYQWIEYVELIAAFIWFFFIIFMGETRGSAILNNKAKKLRKKTGDSRYIAKTELNKPTIRELVTVSLTRPLWILCTEPIVIFFSFWMGFAWFIFYSIISSIGHIFQTQRDWSAGSIGLLYITFVLGLGLGGIANFFLQERMYQKKKTPEARLYLAMVGGVCLPIGCFIYAWTSYPHVHWMGQCVGLTIILFAIYIIYNTAFAYMSDAYRLYASSAISAQNVFRNILGGTTPLHITKWYNATGYNWTSCIIAIIAAVLGVVPFILFKYGEKIRQKSQFSQSISAYEEQERTMLGLDETSSFDKPAKLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA48</accession>
    <name>I4YA48_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_33051</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959102.1">
        <property type="nucleotide sequence ID" value="XM_006959040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA48"/>
    <dbReference type="FunCoup" id="I4YA48">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA48"/>
    <dbReference type="GeneID" id="18471613"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33051"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="I4YA48"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="58"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="379"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM20840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="622" mass="69261" checksum="3E0CB2D9F783885C" modified="2012-09-05" version="1">MSNGASKPEDFKNKTELNKPSNEVTTKQQRQMDWNIIKLLIKNVWPKGDNKTKFRVSIALALLVSGKVLNVQVPFFFKSIVDSLNIPVDPSMTVWTVAGAAITGYGLARIGSTTFGELRNAIFANVAQRAIRRVSGNVFRHLLNLDLGFHLSRQTGGLTRAIDRGTKGISFLLTSIVFHIVPTALEISFVCGILSYKFGPSFAGITLATMLAYSWFTIRTTSWRTRFRKEANAADNAGATVAIDSLLNYEAVKHFNNEAYQAKLYDGTLKKYEDASLKVATSLAYLNSGQNFIFSTALTAMMVLTAQNVLAGTMTIGDLVLVNQLLFQLSVPLNFLGTVYRELRQSLTDMETLFNLQSVNVNVKSKEKAPPIDFKGGNIRFENVQFGYHPIRPIFKDVSFNIPAGKKVAIVGPSGGGKSTVFRLLFRFYEPTSGRITIDGQPIDQVDLESLRKIIGVVPQDTPLFHSDVMHNVRYGRLDATDEEVKEAARKAQMIKLIESLPEGWSTSVGERGLMISGGEKQRLAIARVFLKDAPILFFDEATSSLDTETERELLNNIQEALADSPRTSVFVAHRLRTVSDSDHIIVLRDGYVDEEGNHDFLMRKGGTYFKMWQQQQLEQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA94</accession>
    <name>I4YA94_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959145.1">
        <property type="nucleotide sequence ID" value="XM_006959083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA94"/>
    <dbReference type="GeneID" id="18474142"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60753"/>
    <dbReference type="eggNOG" id="KOG4689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190675_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA94"/>
    <dbReference type="OMA" id="TEYTMEL"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="82"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="25626" checksum="67449A96F27688D3" modified="2012-09-05" version="1">MPAYADTYATTTNDGPVILTIDGINEEDCEVDYTMDMDHSLDEEAINVVADVRNNNSIRNDTTMDNLMAVDVQTDSRIFPSSLLVLDTNVLISKLDTLKSLHELLLKQNPAPFGIIIPDIVIRELDAQKDSSRSISKYSRAALSWCVDCARSRTSLVKFERSSLVNAENDDRILGCASDLQTRAVVLLLTNDNSLAIKAESLGIQTMSTSDDEMRHLRGIAGDNSLSASRHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF8</accession>
    <name>I4YAF8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 1 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_57805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958943.1">
        <property type="nucleotide sequence ID" value="XM_006958881.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAF8"/>
    <dbReference type="GeneID" id="18472955"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57805"/>
    <dbReference type="eggNOG" id="KOG1858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001202_3_0_1"/>
    <dbReference type="InParanoid" id="I4YAF8"/>
    <dbReference type="OMA" id="QIDACKE"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="7">
        <location>
            <begin position="1431"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1761" mass="197013" checksum="CDB47DE3EB17471C" modified="2012-09-05" version="1">MIEIENLSSPATNYLNKVNSSPNYPPPPPSIEPGLFKLYQPPLPLPLHRVLNKDYELAWQNSRLIISKNSQIQRILNFDDDHLNISYASFGNLHLSDDTDKPRECLIVFLHSSLNSNSNEYDLDLAISSTANLARLFFMDPGLDYSLPLPFNVSKAWDLGLGWLVERSDARRAGEKVSSWAVLSGIWHPWRPIGGCKGYDAYRSPIRPFDFTPRPKSKIILITPTQANNQSTKDNWPFLISFDSQTKTLSLYRYTRLKKPIKTSPPSPDYGAPSALPNAPIVSSNLRKISTPRPQSSRRRSSLKSKANVNTLENTFDNSDISLTMDRMILAGESASNRTAPGSKPDENQTLSNESDVFIDLLWECKAADIDSSIPSAHAFAQSDSQISIAIHFPGLSSQLTIVNISRDPTLPITSQLKIEKRETAVTQATAVSSLKCTQENTDDLLILDNSKRLQILINDVDEFIPITLDLDNGDQPRSFKDANGSCLSVETTASKIHRYDFSKWPNDNLTKSCVDLIASFLKENEKLEFALSIFKHFTSVSKGLDALIESLAYFLNVSDSTRKSTSTDTLNKLLQSKAHQRALNSSRIFAIPPKIIKAPRVRNDDIDMNIKVHSALPQILLAIHIVAENSLLDTTNRFDNLTSLAPILGWLGRLAGRADYVGWWERWAGEYAPLLYDKEEYSPNVMDALPPPPSIYDDLHSRMHHSISNYPIIPQNQLHGTAALQKVFTLLGDSKCEEAVDELILHGYNKDKIRCTPLHLSVILQEVLRACQIRPKLRWSSEAYQLIGREDLVANADARERQGRTDEAKTMLSIESIKDIVRTKKEEDQTNSTSKGKVISGVEIDNLEIPQLRFSEDHRLREVTRILNSSELTKLRFLNTSGLLEPDFLKEQENVTNAMPERTLSLPFGRGMLTYGTSESVPAGPLNIPDFDFRVKMIPTNATYDLDSSLNPPEFKDWSEFSNGVASALKLGEQLNVDESWIMLNKPTKNVMSPRHSGLMLGLGLNGHLKSMWLGHIQKFLEPKNEFMTIGTMLGVSISYAGDPPERLVGAFSLHIPAILPSHQLEFNLSGLTQAAGLFSLGVLHLGTRQRRQAEMLLGEIGGRDVPTNDGKSNVRGSYSLSAALGFGLVMLAKGKEATSPSETQMITKLRHYIHGDKHRSNETDVEYDALDVNFTSPGASLALGMWFLKSERSDVAPLMDLPCNPTELDWIRPDFLLFRTLSKNLIMWNTIGRDREWVESQIPHFIQIALERKKERFESVDDNIELAYYNIVAGACLAQGLKFAGTAEDDTFKCLLHYMDIFTQAASIKSITYEGKVKRAAIRSGLNTITVAIATVMAGTGELGILKRLRIAHGQFGQASGRNFGSQMAVHMALGMLFLGGGEYTLTNSNEAVGFLLCALYPKWPMSINDQSNHPFAYRHLWVKAVQKRCFIPRDVKTNEAVYVPIKIKAVDELDKQPKSMRMIAPTLVPKYSRLLSLKIDSPRYWPLVIDFNDENSLRNLKASQTFYVKKKAGYLSYASDPKNLKSTASRNKIGLDLVAMMKMDLVPNQRLLRSDNYEEVENSLEFSDSLASLARFARSGGNNNLIDAILLDALTNDKPVGVWYHLSLNRLCNLAQKNTYSLKETMELVLSARELNHLQVAYSGVLKNILGDLPPLLQSSMIVYALKILNNVNVDENVLHDVLAGRTPEWKAGIHLSAYNYPDRGTIITLLDKLSTLDSDEKTLRLIVQLTLSQLSNVSSSKQVVDTIYNAYKRKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAQ2</accession>
    <name>I4YAQ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959030.1">
        <property type="nucleotide sequence ID" value="XM_006958968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAQ2"/>
    <dbReference type="STRING" id="671144.I4YAQ2"/>
    <dbReference type="GeneID" id="18475587"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69465"/>
    <dbReference type="eggNOG" id="ENOG502RZ5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072626_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAQ2"/>
    <dbReference type="OMA" id="GLDICKP"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="22430" checksum="CEBA89A8BE967207" modified="2012-09-05" version="1">MTPISSTTISDAFHKLDPKPSTGGYLPDLHSFTGSQTLSAPVFPIKFVYKDSGTAPLRQHFVDLCPEGHILLLCPPEDSTNACFGGLLATAAAAQSVAGVVANGRVRDLDELEDSGLTIFAKGTSVCGQAPFLAPVSAGETVEITHPNGHKITIKSGDQLFADRNGVIVVDSTRMNEIEAIAAKSEQTDELCRQALAKGDSVKEVFAKYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAU7</accession>
    <name>I4YAU7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958771.1">
        <property type="nucleotide sequence ID" value="XM_006958709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAU7"/>
    <dbReference type="GeneID" id="18474036"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60573"/>
    <dbReference type="eggNOG" id="ENOG502SA67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778910_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAU7"/>
    <dbReference type="OMA" id="ATWYSAR"/>
    <dbReference type="OrthoDB" id="10666384at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="37266" checksum="9206CD71441AADB2" modified="2012-09-05" version="1">MLEKRLTHRHHNHHRRAIFDGILGDSKDSSSSKSGSSSTGSSSTGSGSSSTKSGSSSTESSSKTDSSSSKTSSSSSSETSSSSSDSPSPSSSPTDSSQAQSTTTDPAGSNNGSNDAPTLGTGPIVGIAAGGVAAIIILAIIIGCCVRRKSKRSKKPVVDPFNRHSFKHEAELIPDPIEADYRNPSPRPNMAGMGAATNNYIPPPSLPGLAHVPRVDTPPMMQSRSPFDPYGQHHQLQHPQLMNVGMVPPYKPNSPSYFPAYSDTLIPPHPPNLDRSPSVQSHSADISSPPMYTPPDNPDFLPNPYENKGAPSGKGNDTTTATYRPTSLRPGMQLPQGGNSRGAAPSHNLNDAYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB35</accession>
    <name>I4YB35_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_46633</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958850.1">
        <property type="nucleotide sequence ID" value="XM_006958788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB35"/>
    <dbReference type="FunCoup" id="I4YB35">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB35"/>
    <dbReference type="GeneID" id="18472393"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46633"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_5_1"/>
    <dbReference type="InParanoid" id="I4YB35"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="87"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="277"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="503"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM21177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="581" mass="65465" checksum="05E6CD688BF7C364" modified="2012-09-05" version="1">MDKSELKKIEKKRKRDLKATEKAPAEETAISEKEDTQLPELPETNTDYQDLTPEQCSFSNLDLTDGTRSAIEEMGFSQMTEVQAKTIPPLMAGRDVLGAAHTGSGKTLAFLIPAIEMLSRLHFKPRNGTGAIVISPTRELALQIFGVAKDIMKNHNQTFGIIMGGANRKAEADKLQKGVNLIIATPGRLLDHLQNTKGFVFSNMKSLIIDEADRILEIGFEEEMRQIVKILPTENRQTMLFSATQTTKVTDLARVSLRQGPLYINVHEERSAATNEQLEQGYVVCESDMRFLLLFTFLKKNLKKKVIVFFSSCNSVKYHGELLNYIDIPVLDLHGKQKQQKRTNTFFEFCNAPNGILLCTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARAGKAGKSLLFLLPTELGFLRFLKTAKVPLNEYNFPKEKIANVQTQLEKLINKNYYLHQSAKDGYRSYLQSYASYSLKKIFDVNRLDLKKVAKAFGFSVPPKVNISLGNSLKTSKDTAGKKGKGMDRLDDEELAAIEDAAEQSDDQDEQDKPKKRRSNKTGQYNKQGVDKGAYRQQNNKNGTQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB85</accession>
    <name>I4YB85_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_38564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958584.1">
        <property type="nucleotide sequence ID" value="XM_006958522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB85"/>
    <dbReference type="FunCoup" id="I4YB85">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB85"/>
    <dbReference type="GeneID" id="18472073"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38564"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103054_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB85"/>
    <dbReference type="OMA" id="YGKPQNP"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="18284" checksum="FCD88229D7310EB6" modified="2012-09-05" version="1">MLKSILNKRLLSTTNYLNKDPFKLPFDPSLSSTSQSDDLNQEFYPKPIERVNESIPIKKSRLLYQSRHRGTLESDLILSTFAQKYLSQMDTKELNDFDKLMDEPDWDIYYWSLNRKPLPQRWENNPIIDKLKLHVKNEEKVSKRMPPVQAIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB90</accession>
    <name>I4YB90_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958588.1">
        <property type="nucleotide sequence ID" value="XM_006958526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB90"/>
    <dbReference type="STRING" id="671144.I4YB90"/>
    <dbReference type="GeneID" id="18472928"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57587"/>
    <dbReference type="eggNOG" id="ENOG502SY2E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082209_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB90"/>
    <dbReference type="OMA" id="DKHIATK"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34242" checksum="57C06ABA8E498A25" modified="2012-09-05" version="1">MPDAKRTKLRNNQEEWIKTAKDVANCAGVNIYDLISRTSAILEFSPVPVRPAVEVLLKIFELVSQVKDQFSQSLRLISRAAKLLKGIKDQVDGIEDLILPQRLLMNIQTFERLLFDIQVFIQKQIESGWLKRFIRRYEIQSNLDNFNDLIDQIAQEFGIRSHLSIHARLTEDNLDRKRDNSQIRSMIGDALKNDEVLLHQLQVQQLTIKSLENAFNEHMVSHFEESDDQPRKLTFQNINENVINQRLSQGVSLSAIKPMLRKIPIVVKNGDAYDDELVHRFIEKSLRVLRRVGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBE5</accession>
    <name>I4YBE5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958640.1">
        <property type="nucleotide sequence ID" value="XM_006958578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBE5"/>
    <dbReference type="GeneID" id="18472934"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57617"/>
    <dbReference type="HOGENOM" id="CLU_866548_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBE5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="36828" checksum="1CDAE8021C76FCE6" modified="2012-09-05" version="1">MDVAFRVMNYRHILSLFVTTISLSGMGIEELIKPNIVNVLLSTAIDYDELRYHSLLIFKYSVYSMGAKMAINLSAKDGLFCLWLREIVYLLSGIVEEDIDEETYEARQFAYQVIRHYEQKNAIDLPVKVLHRNLSDEVVNELLKSIKNHVGDTLSQSIDDYAITAISIRENKVNEYGNLRYIKTDQSEDLVDVLTTTNNDEYLSDYPEFFCIVNRKANTTVKATIENNPLLCYDLFFNLQLYLCNHRRPYKQLAPTILLNSDVIFNISLLKTFIVTSDSFSDLQPGDNFINQLLSDTKDTSHTKAINAVKISLLNKSITFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ6</accession>
    <name>I4YBJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958686.1">
        <property type="nucleotide sequence ID" value="XM_006958624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ6"/>
    <dbReference type="STRING" id="671144.I4YBJ6"/>
    <dbReference type="GeneID" id="18471557"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32787"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBJ6"/>
    <dbReference type="OMA" id="WMGNFTA"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="49"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="428" mass="48385" checksum="12BA698564218449" modified="2012-09-05" version="1">MSKTIKQLVKVGAFFCILTVFVQFNTLRLKFTGYNNTTSTTSTDMATGMRNVGYFVNWGIYDRNYNVKDIPAAYLTHLLYAFANVDPNTGAVHLSDPWSDEQKHFDGDSWNDSGDNLYGNFKQLYLLRKQNRHLKLLLSIGGWTYSPNFHNVIIDEGKRATFVNTAVKILNDYGLDGLDIDYEYPQNSNQAWGYVELLRELRIALDHSGAQNRVQNPYELTIAAPCGASTYEQLYVREMDPYLTFWNLMAYDFAGSWDSVAGHQSNLIGYPMSVDAAVSWYKSKGVQSEKLVVGMPLYGRSFTKTKGIGQSYSGVGKGSWEAGNYDYKALPLPDSQEFFDSEKIASYCYSKNSKELVTYDNVDIALRKAEYIKQNGLGGGMYWELSGDNPEVPKSIVINVALNFTRLDGVNNHIEYPQSRFDNVRNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ7</accession>
    <name>I4YBJ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1000-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_38676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958687.1">
        <property type="nucleotide sequence ID" value="XM_006958625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ7"/>
    <dbReference type="GeneID" id="18472076"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38676"/>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_2_1_1"/>
    <dbReference type="InParanoid" id="I4YBJ7"/>
    <dbReference type="OMA" id="DRDNVHG"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="19493" checksum="9185125FC6EF4F6E" modified="2012-09-05" version="1">MADNLYEYIHKSQVTALNVNPEHEVQSIIKEYAERNTVTPHIESWVDDQLIVFIPFTTSVKLKAILLGTDSGDLRPSAVKIYSNHPHCPDFEQLDGTACLQDMSLEATSNESSGDLVKEYPMRVARFTNVFSIVLFFPSSFGGQNTRIYYIGFKGEVLTPNKERSDRVSLADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL9</accession>
    <name>I4YBL9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_19040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958582.1">
        <property type="nucleotide sequence ID" value="XM_006958520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL9"/>
    <dbReference type="FunCoup" id="I4YBL9">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBL9"/>
    <dbReference type="GeneID" id="18470791"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19040"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055356_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBL9"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="27914" checksum="DD19CD8FC4E3F6ED" modified="2012-09-05" version="1" fragment="single">TMSRTPNFAKGVEYWSSTEASYNGVLGGFGLGTLPRVDAQSSRMMILKLLPRLSQTKSIMNPKPSERLESRAMEAGAGVGRVSTDVLLYYSKHVELVEPTPKFTERARQRLAEHPKVTEEGATWTIKEVGLQQWQPDGIYDLIWSQWCLPHLSDDELVEYFKKAAGSLRKYTTGDEFYGQDGLLVVKENVCSDTDYTLFDDEDSSITRSHQAYLDLFQKAGLSIVHQEVQLGFPKELYQVRMYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC74</accession>
    <name>I4YC74_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Plays a central role in virulence and antifungal drug action.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958264.1">
        <property type="nucleotide sequence ID" value="XM_006958202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC74"/>
    <dbReference type="FunCoup" id="I4YC74">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC74"/>
    <dbReference type="GeneID" id="18473885"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60317"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="InParanoid" id="I4YC74"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="175" mass="19593" checksum="4A2A80EBA48B7F47" modified="2012-09-05" version="1">MGQSGSQVLGDLERNSNFTAAELQRLKKRFMKLDRDGSGSIDKDEFLQIPQVANNPLAHRMIAIFDEDGGGTVDFQEFVGGLSAFSNRGGKDEKLKFAFKVYDMDRDGYISNGELYIVLKMMVGNNLRDQQLQQIVDKTIMEGDKDGDGRLSFDEFADMVSATDILKQMTLEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCF5</accession>
    <name>I4YCF5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_18505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958243.1">
        <property type="nucleotide sequence ID" value="XM_006958181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCF5"/>
    <dbReference type="FunCoup" id="I4YCF5">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCF5"/>
    <dbReference type="GeneID" id="18470771"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18505"/>
    <dbReference type="eggNOG" id="KOG0902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000893_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCF5"/>
    <dbReference type="OMA" id="TIEVWQS"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="920"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135786" checksum="82D5342ABE47C288" modified="2012-09-05" version="1">MQTIALKSPSLNFSQTDITSHASIQEKRASLVKLLPKQANDIRYLSSDDVVLLLTVYKLENIRCQHCHPSGILNYFQDDCFSESSSSECIKSIADSLTNTFIQSWAIRSRSQSIDVKLLDEIKALLVGTCHRLEIVRSIAFSFSNRLLTAIPNLVSKQVIIFTILELLSLLHESCTNQLEFEYSFKFNYSSTLAAFEVDLPDNYSLKDSLIKKLTHSLDVWVISALPGANLELSSALSVYLSETSEASPTHYGASLALKYSLKIPSSDSHLASKSQLDEDLAGAFSNRFGLRCKTNGEITGVRLALKKGVNEMHKIPDNEISKEDVRRLKKQTQDLLYGIHNKECDLTLPDLKRLLWRCAGILVASNKLDFELLHYLVSVPFQVFTGDSISTALEVWIWLFHERKDFQTKTIMEICNEWLSTIKARKGLFSTVNSEIDPFHDGIEYSPSNEEEMNNNATVAKKTFLPHLYVIQLLNGFLTSLESHDPVAIFTISKCLYKSTKSGLMSRHPLSRELRFTILNTAFRVIRTASLDSNSESLLRESTLNCALSWFTVKPHWCFGGNRLQIKSDIQCLNVFLLNIKSSGSLSTSMDNTYKERIKLLEVLLDNEVNKLKVWLDPLNDAERGGYLPSLMHNATISEHEWHKYINIAWAHSTELLMGLASRFKSPTITRELKKLARHFTNSFIDIPEALEHFLNGGLQELSSTSLRFLNFWAPVSPSSALAYFQPEYKNDSMILQYAMKCLEHHTVQLTFFYVPQIVQALRDDKLGYVERFIFETAKISQLFCHQIIWNMKANTHRDDNGELADPMKPLLENMINMIVSSLSGDAKDFYEREFTFFDSVTSISGKLKPFVKKSKPEKKEKIDEEMKQIEVDPGVYLPSNPDGVVVDIDKVSGRPLQSHAKAPFMATFKVRKEVVNLESADDGILDNDQEEKKHVFEKWQAAIFKVGDDCRQDVLALQAIAIFKTIFFTSGLALYLNPYRVTATGPGCGVIDVVPNATSRDEMGRAKVNDLAEYFLQTFGSKESMAYQKSRLNFIRSMAAYSLICYILQIKDRHNGNIMIDGEGHIVHIDFGFLFDIGPGGIKFEPNSFKLSHEMVTVMGGKDSDGYKMFQELIVKGFIASRIYANEIVNVVKLMLGTELPSFKGEGTISRLRDRFMLHLDDRAASQYMIGVIRNAHENSRSIAYDEFQSRCLHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCI7</accession>
    <name>I4YCI7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_45948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958366.1">
        <property type="nucleotide sequence ID" value="XM_006958304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCI7"/>
    <dbReference type="FunCoup" id="I4YCI7">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCI7"/>
    <dbReference type="GeneID" id="18472373"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45948"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCI7"/>
    <dbReference type="OMA" id="LAQSCKI"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="543"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="714" mass="79540" checksum="507490DAA1C83598" modified="2012-09-05" version="1">MPPNSKVENEDEEQGLQAIVFADSFNARFKPLTDKKPRCLLPLVNVPMLAWTLESLAAAGIRHVFLFTCTHADQIKEWLKKSHFSSALSTLAVTPIVSTTSVSAGDAIRELDAKQLIRTDFVLISGDVVSTIDIQKIVDEHKERRKTNKDAIMTMVTKRVGASHRLRPPAESPVFVIDPSNNQLHSYTTLAHPSLSSSATHKRVNIPSEALEAAELQIRNDLADCYIDICSVDVLLLFTENFDYQDLRLDFINGILTSDLLGKTIHMHTIEDETGGYAGRVMDGRSYDAISKDIISRWTYPMVPDESMPDSERLHHQRGHRYFGKDNVQIGESASISVCSVIGSQSKLSDKSKIERSVIGQSVQIGESSRISHSYIWNKASIGNSCDISESIIAESARIGDQVIISNGCFVGENVTIASGTKLPPFTRVGTTRWNQEEEDEEDEAEKEERLKILGEESNGYLWPSDKVDMQIDEIDSDDEEDEDFQLSMKYSRMGARPPSPALSTSSSLSTISNGGSDEENDDDEDDINDAVEGLTLENAGKVGAAADFSHECVQSLERAFEEGHTSENAAIELKTLRMASNVQLSQVRKVVIDFCMSRISTTDGQPVKAVEAVFGRWAQLVIEMTKEDQSQAILIAQEYCARHPQSHLSIFLAVLRIFYEYEIASEEAIFAWYKSQPARGESESDMRVLWEKSRRFIEALLEADSESEEEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD17</accession>
    <name>I4YD17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958160.1">
        <property type="nucleotide sequence ID" value="XM_006958098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD17"/>
    <dbReference type="STRING" id="671144.I4YD17"/>
    <dbReference type="GeneID" id="18473857"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60275"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376067_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD17"/>
    <dbReference type="OMA" id="TENEAWQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="738" mass="82980" checksum="312D481606CA9B50" modified="2012-09-05" version="1">MSRVLELDDNILFEILNRLRTVDLVRLSMTCRSFNNIAKRHLSFVGAHWDQFDVQRAPGFPSPSKLQPTINFHKDEDLTTDVEEHIPEIFPPAFGHQSAVQIRSYLYLPYLSVNPSVYVLNLKTRLWDRHFLKVQAPKYAPNQSYQWQPLMAPITAYNDELYLFGGTRHPKVKSDHPTQATTIDERSTGVLSDSIYKINIEDWTIQELGNSRHPEAYLNNFSKRPRKRPSNSSGSHEESIWPPARRGHSIATMRDSLIVFGGICENSIGDNDVFVYDFKQETWKLPDIKGSAPDVRFGHAQTVVGDEIFYFGGAQVDEPVNVIFDNLHKLSYNVIEDSFTWYNYRSPEAYSQARFEKLKVKRQFQQHQRDENMQIDTGIQRRYTGTESDDSLEDLITTTGQPPRERLESTMILVGSHKLAIFAGVTIVPASHDYENYDEYCAYNTTAIDVFDFRHNHWTRLGVSGSGSAINTFIVESCCAFIAPPGYYDHDAYKPHDSEPEAWQFIVVGHRLHWVDFQINKCSTDARTEVLIEDPKKGLNVSKLTSRAPSEIVLDIGKMIGSGEIAPTLADQNAAIHGEGPRLPSNGQTRRPSQEASYIYGPTAGHVKPAAVGTVPKVPDEVTNGGSTVKKSKGDKMGSWMTFYSRDNTVILASTTARKKRIGESPNDSPSTDSSDSMIMIDNPQDKSSTAGEVDEPDDVANSFGPSHLRETGYNTKKGEDAFSLSTVGFVKSLAFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD47</accession>
    <name>I4YD47_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_32436</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958190.1">
        <property type="nucleotide sequence ID" value="XM_006958128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD47"/>
    <dbReference type="FunCoup" id="I4YD47">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD47"/>
    <dbReference type="GeneID" id="18471488"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32436"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_5_1_1"/>
    <dbReference type="InParanoid" id="I4YD47"/>
    <dbReference type="OMA" id="GQANDEK"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="184"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="45296" checksum="A1F0B7967A7A97E3" modified="2012-09-05" version="1">MSSLSVQSYHQDSPPFTGQANDEEIPPLELLHVSDSNRSSPNSSTSAQSEPKNQLRGKAAFSPMYSPRPDGSAQPSPHPMLSDLPSSAANAIASRAVRPSVQRESSQVGIARDRVPKEPMTAPEAINERHDKAPVTPNPFSQTKDFSPPDLDEADLFGEDGYIFPKHKLKGMMEDEEKIPLVIVACGSFSPPTYLHLRMFEMASDQINEKGKYEILGGYYSPVSDAYKKSGLAGAKHRVMMCHLGVECTSDWLMVDPWEANKKEFTRTAHVLDHFDQEINECEEYGVKLRDGSRRKVQIMLLAGGDLIESFGEPGVWSEDDLNHILGKFGCLIVERTGSDVWAFLLSHDLLYKHRRNVIVVKQLIYNDISSTKVRLFVRRGMSIRYLLPSAVAAYILNNKIYASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE5</accession>
    <name>I4YDE5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA supercoiling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_37435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957797.1">
        <property type="nucleotide sequence ID" value="XM_006957735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE5"/>
    <dbReference type="FunCoup" id="I4YDE5">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDE5"/>
    <dbReference type="GeneID" id="18472014"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37435"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="InParanoid" id="I4YDE5"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="234"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="566"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="806" mass="90614" checksum="8E5977948F79F6E6" modified="2012-09-05" version="1">MYRAKTAEPSSSTSSSGSTSALAPPSSILAKPFKVPTLSSDKLRAAAPTRVAKKRVSYKEEESKENRKRGKVDDDYHEDSGVNRELGFDLKTLYPVYEVKPASSVLGQGFKIPPMKDKATGRQVIIPLSGMALGTRIQPPIPPRPLHDPMAEHAIVLYDPTIDDIEEKKEEPAIPKPPVDRRNRSVKDILGIKSREELEKDVKKVPVVIDPILSKVLRPHQVEGVKFLYRCTTGLTAPDAQGCIMADEMGLGKTLQCIALLWTLLKQSPIPGKPTVEKCIIVCPSSLVPNWANEFTKWLGTGAVGCMAVDHKGTKEQLISDVKQWCAASGRSVTQPVMIVSYETLRNLTEVIGRAQVGLMMLDEGHRMKNSESMTFKALTEIHCKRRVILSGTPIQNDLSEYFSLLNFANPDYLGNKNEFRKNFENIILRGRDALATDKEKQMSEEKLKELNMAVSKFIIRRTNDILSKFLPVKYEHVVFTALSPLQLDLYKFFIESPETQALLKGKASQPLKAIGILKKLCNHPNLISPKDDIPGSKVLLPEENIAERLDKKRPANPAWSGKMMVLMRFIERMRKNSDDKIVLVSNYTQTLDLLEKLFAALRWGFMRLDGTMAVKKRGKLVDRFNDPESREFIFLLSSKAGGCGLNLIGANRLILFDPDWNPAADQQALARVWRDGQKKECFVYRFIGTGTLEEQVLMRQAYKQSLSACVVDEAEDADRHFSKDLLRELFKHYPGTDSHMHDTFKCKRCDKATGKQIVKAPALLYGDVSTWNHYSNACLKDIHDDLLRAETGMPDVTKVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDJ3</accession>
    <name>I4YDJ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957841.1">
        <property type="nucleotide sequence ID" value="XM_006957779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDJ3"/>
    <dbReference type="FunCoup" id="I4YDJ3">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDJ3"/>
    <dbReference type="GeneID" id="18473765"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60138"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_0_2_1"/>
    <dbReference type="InParanoid" id="I4YDJ3"/>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="29927" checksum="83A1A46053A4DAE8" modified="2012-09-05" version="1">MSSTSQRGIHVHPAALFSILDHFMRRPMQQERVIGALLGSRSSESDVEVKSAFAVPHSENDEQATVDSEHLQSMLDLHLKVNPREVLVGWYATGSSLNAYSALIQNFFTQQNTQPYNAVHLTVDTQNFNFKDAVKGYLGSSLGPLPKMDNCVFQSLPVDLLVREQEKASLDALAAPPKQTLDDIPALRAALEKLSAQIDEVLAYVEKVVSGEVEGDAVVGKALLSAVQSLSTRFEEGDLNKILDAHIQDTKAVSYLADLIRTQADIASRLSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW6</accession>
    <name>I4YDW6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_17790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957747.1">
        <property type="nucleotide sequence ID" value="XM_006957685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW6"/>
    <dbReference type="FunCoup" id="I4YDW6">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDW6"/>
    <dbReference type="GeneID" id="18470740"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17790"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="I4YDW6"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="421" mass="45858" checksum="7434C844360F0F37" modified="2012-09-05" version="1">MSAHAIDLETKHSAHNYHPLPVVFDSASGAKVWDVEGVEYLDFLSAYSAVNQGHCHPKIIEALTRQASKLTLSSRAFHNSVFGEFAKKLTDLLGYDMVLPMNTGAEAVETALKLARRWAYAKKGVSENDAKILAVEGNFHGRTLAVISMSTDSEATHQYGPFLQGVGTSFDDTRIRYNNIDDLHRVLEKYGHQTAAFLVEPIQGEAGIIVPDHDYLRQAKQLCEKYNVLLICDEIQTGLGRTGKMLCCEHSGVRPDVVTLGKALSGGVYPVSAVLADADIMLTITTGSHGSTYGGNPLGSAVAMAALDVIIDENLVERAEKLGHIFRDAVGKIQSPLIDQVRGKGLLNAVVIDESKSTRGRGAWDICILLKKYGLLAKPTHQNIIRFAPPLVISEDDLLRGVSIIEKALNDLDKVDHISEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE49</accession>
    <name>I4YE49_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_44583</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957505.1">
        <property type="nucleotide sequence ID" value="XM_006957443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE49"/>
    <dbReference type="FunCoup" id="I4YE49">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE49"/>
    <dbReference type="GeneID" id="18472335"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44583"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="InParanoid" id="I4YE49"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="9978" checksum="5734D60F5421AF4F" modified="2012-09-05" version="1">MSFLFGGGGATSNPVAQSEVVQSATTEIEMITDLFSKLVDSCHKKCIEKSYRDIDLTKAEGVCLDRCVGKYFETSKLVTEKLQKLQQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE60</accession>
    <name>I4YE60_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957516.1">
        <property type="nucleotide sequence ID" value="XM_006957454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE60"/>
    <dbReference type="FunCoup" id="I4YE60">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE60"/>
    <dbReference type="GeneID" id="18473660"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59971"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="I4YE60"/>
    <dbReference type="OMA" id="PTQSAYC"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="284" mass="31064" checksum="A3CBA4C08C6ABF60" modified="2012-09-05" version="1">MSQKVFYITGSSSGFGRFLTNELAKRGHKVIATARTISKINDLSNGDNIKVQQLDVTDSPDIIEKKVKEAINFFGRVDVLVNNAGYSQAGCFEELTDEEIRKQFDTNVFGPVKLTKAFLPYFRSTQTESVICAISSAVGITALPLISAYSSSKFALEGFFEGLDGEIRGSDLPIRVSIIEPGMFKTDFISNVQKAQTQIGQYDSLRQQSMTRMVETLSKAGDAAIGAKLIADALLKEGFAANKDIPLRLPIGTDSVETSVSKFKQTSDIFSEWRPFAAESDPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE68</accession>
    <name>I4YE68_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PIG-U-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_36984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957524.1">
        <property type="nucleotide sequence ID" value="XM_006957462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE68"/>
    <dbReference type="FunCoup" id="I4YE68">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE68"/>
    <dbReference type="GeneID" id="18471990"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36984"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE68"/>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="42036" checksum="BD4C069B1E8BA5FD" modified="2012-09-05" version="1">MTTVYFASGFALRAILINYFEFLNFFELSNVFNSAFIVKESAVRGTFDYISPLLLHFDSKVYYYILDVIAICALYRINKQSALFYTYSPLSIVNLLSHSLTTLQNTLTLTSLTLACEGYAYLSILLLSYNSILFFYPVALLIPQILIITKDSTNKVKELTKYTLVYLITTLSLLSLARYISNDWSFLNLYKNLIFAENLTPNTGLFWYLFMEIFSQFRYFFTVVLQLHAFIYVLPISIYLSHRPLLAFTFISGTISIFKSYPSIGDVSVYTSLIFLFPDLYQHARYPKFVATLTIVAAGLLPLFRHLWLRAVTGNANFYYASTLLWTFSNGMLLVELLYAEAKRLFMMTIDKDTDISQYKIKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEA0</accession>
    <name>I4YEA0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_44677</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957549.1">
        <property type="nucleotide sequence ID" value="XM_006957487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEA0"/>
    <dbReference type="FunCoup" id="I4YEA0">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="GeneID" id="18472339"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44677"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEA0"/>
    <dbReference type="OMA" id="KDWQLIW"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="128"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="561" mass="62778" checksum="C804924968DCCA34" modified="2012-09-05" version="1">MSPSVSEKYMNFPDEPYLWKFGPEDDNPEEDDGLHYPEESAKATDKESSGPVWTYRGIMNIGFLAILTAAILMLFAGYPILGYARAAERSKQGGYNIGFINSTGQIAAISGHRGLVDPDTPEEARTRVGYDGKDYELVFSDEFNIDGRTFYPGEDPFWEAGDLHYWGTNNLEWYSPRQVTTEGGALRITLDEVASHDLEYEGGILTSWNKFCFTGGYISASVQLPGSSDVWGLWPAFWTMGNLGRAGYGASLDGMWPYSYDSCDVGTLKNQSLGVYPPESRTNGDWAYDYSVSYLPGQRLSRCTCDDQDHPGPKHEDGTLKGRSAPEIDILEAQVDQSTRMGHLSMSGQFAPFNSFYLYDNTSDLAVLTHPETDEVNGYHGSVFQQSVSGVIRTNQECYQFESGCYDEYGFEYHPGADGDIKWSVSDEVRWSVKAGAIGPDPITEIGQRTIPEEPMYILINQGISNNFGDIDWDELIFPSIMSVDWVRVYQPVGERNVGCDPPDMPTSDYINRHIDAYMNPNLTTWQQYTDELWPLNALEHQNDETCQTALNIAPDNLMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF2</accession>
    <name>I4YEF2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_37125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957599.1">
        <property type="nucleotide sequence ID" value="XM_006957537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF2"/>
    <dbReference type="STRING" id="671144.I4YEF2"/>
    <dbReference type="GeneID" id="18471997"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37125"/>
    <dbReference type="eggNOG" id="KOG4708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126331_2_1_1"/>
    <dbReference type="InParanoid" id="I4YEF2"/>
    <dbReference type="OMA" id="HQIGDYW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11461" checksum="DA27B3BCFF259476" modified="2012-09-05" version="1">MPLYNILCVAAHYPEIAPIRELLKTTTQIINNGGGLIKNVDYWGTQTLPNKMIRHQQIYDKGDYIHMSFLASPPLLKNVNNLLKLDPRVIRWQTTKEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP0</accession>
    <name>I4YEP0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957675.1">
        <property type="nucleotide sequence ID" value="XM_006957613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP0"/>
    <dbReference type="GeneID" id="18475387"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68387"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_2_1_1"/>
    <dbReference type="InParanoid" id="I4YEP0"/>
    <dbReference type="OMA" id="NHGSRKV"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24943" checksum="32A2D9E3CF808F16" modified="2012-09-05" version="1">MEINVGGIKSIIYGLDNLNKQPKRDLAIVFILHGRGESQDGIRQRLIATKCVSVANESDKRTRNLIAVTFDQRNHGSRHLSDLQNQGWPKNPNHLFDMFSIQQGTSRDVSYLIDYLPSFLFPNNEQNVVDFGCVGSSLGGHATWMALRQDERISVGAPLIACADYLSLMQPRARKHNVDLNPPETFKQLIKKYDPMASLASSTDVWKGKKIMALSGSDDKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF13</accession>
    <name>I4YF13_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957225.1">
        <property type="nucleotide sequence ID" value="XM_006957163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF13"/>
    <dbReference type="GeneID" id="18473569"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59824"/>
    <dbReference type="HOGENOM" id="CLU_900799_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF13"/>
    <dbReference type="OMA" id="DIANAHR"/>
    <dbReference type="OrthoDB" id="10415894at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="34189" checksum="DD5E5BED3FC8F359" modified="2012-09-05" version="1">MKSKLWQLGRQLKLAKFARSNPTKSLKGLINPFKAALASPTRVVQSTARQAPRTIHRSAFHPFGQSLLVKSSTRPAFGNFANRTSQAGLGSARTFATGRGAIDVMQNVNVFARCALNQLGEHKLSALQSSSLKRNRKQKNESFERLQDFKDYFVVPEFKTVLAAPISASLSHLLTDKPKGSECGEYALFDEEFVKDLINLKVSSKVHSKRLDVLCASVKPIADTLEITNIPGNDLLILKATFDGITPNEVEAIIQKRLASYSLDEINNAHLMAGWYRLYQVNEDVVLHDIVSQSFCLPDPASSLESSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF78</accession>
    <name>I4YF78_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957286.1">
        <property type="nucleotide sequence ID" value="XM_006957224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF78"/>
    <dbReference type="STRING" id="671144.I4YF78"/>
    <dbReference type="GeneID" id="18473590"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59856"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1950489_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF78"/>
    <dbReference type="OMA" id="AFEMREN"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="134" mass="15012" checksum="AC81AE57FB047ACA" modified="2012-09-05" version="1">MLRNLLPKIQPVVGTRAASTFAKITLCGNIAEPEIKTGKNGKDYARLPLATSVSVAPAEDGQPQEETNWHTVFAFGEQVERIRNLRKGSLLYVEADYSLQKYQQDENSPIYKLPSIRARSIKVLKRSAPKENIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF90</accession>
    <name>I4YF90_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_36655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957298.1">
        <property type="nucleotide sequence ID" value="XM_006957236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF90"/>
    <dbReference type="FunCoup" id="I4YF90">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF90"/>
    <dbReference type="GeneID" id="18471972"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36655"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_2_1"/>
    <dbReference type="InParanoid" id="I4YF90"/>
    <dbReference type="OMA" id="ITHFVYH"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="183" mass="19928" checksum="DFB70527C2A07F64" modified="2012-09-05" version="1">MDKELIKKSLGVHPDFPKKGITFLDIFPILQDPFKFEVLITHLLSHLHSHTIPKLSNGGKIDVVVGLDARGFLLGPVLAMRLGAAFVPVRKGGKLPGQCSKVEYSLEYGKDVFEIQSNSIKQNQNVIVIDDLIATGGSASAAGQLIKQQGGNTLEYLFIVALPFLKGLEKLDAPAYYIVEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF91</accession>
    <name>I4YF91_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-related protein Arp4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957299.1">
        <property type="nucleotide sequence ID" value="XM_006957237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF91"/>
    <dbReference type="FunCoup" id="I4YF91">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF91"/>
    <dbReference type="GeneID" id="18474824"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63267"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="InParanoid" id="I4YF91"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="423" mass="47240" checksum="084FAE39EAC64402" modified="2012-09-05" version="1">MVIYGADQVSALVASAGNSTLSAGYAGEDVPKTVIPTHFSHLNDKSYFGDNGPDVYRPGYQVSNTMKDSLVDDFDKFTNLLEYTFNDDLRVNTEDHPLLLTEPAWNTQKHREKLAEIAFEKFKVPGFYIANESVLSAFAAGKSTALIIDIGSDSTSITPIIDGFVLRKGVIRNNIGGNQLTNAYLESLDENQRQNVLSNLIPHQLIESKTTVELGQSPKFNLRSDTNPTDSWLEYSKSKILKDWREATTAVYENHIWDDLNVLQRPIKSFEFPTGFADNFTTSRYKASEILIDSRNFNPVQFTPNSFEPASINPSDPKSIAELIKESIQSVEHDSRTQLLSNVILVGGVSSTTGLSERIQAEISKFHTNSRVKVHSPANTVERKFAPWLGGSILGSLGTFHQLWISQDEWREFGHPIVSMRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFD0</accession>
    <name>I4YFD0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_53945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957337.1">
        <property type="nucleotide sequence ID" value="XM_006957275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFD0"/>
    <dbReference type="STRING" id="671144.I4YFD0"/>
    <dbReference type="GeneID" id="18472641"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53945"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_3_3_1"/>
    <dbReference type="InParanoid" id="I4YFD0"/>
    <dbReference type="OMA" id="GNWNYTA"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="438"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="554" mass="63793" checksum="124231826EB744FF" modified="2012-09-05" version="1">MSARVLHWFRTDLRLHDAPALVKGLELKPEAFFPVWAWDPYFNFDCPVGPNRYKFLIETMNELDGKLNDMGNKLHVFRADPADLFPALFKQWNITHLVYEKDPAPYAVERDEKIKQIATDAKVEVLDITGHTLYDIDAVIEKNKGEPTTTAQGFKNLVKDMEIPRPTEGPTSMPKADNLKLEAIRKEVKLFKPGHDINAEHRKGRMTVYDSVTGVKDILASPTLEELGYDVKEATTQIPGGEDEALRRLDKWIQDEDATATFRKPQTSPAEYDPPATTQLSPYIKFGALGVREFYWKVVDLMDQYDGETSSEPENLPGQLIFREMYFAAQLAIGKPFGQIRGNKICRLIDWKLCNVYDENGEQIIPRPKGPKEDEEALQKWADGFTGFPWIDAAMRQLKQEGWMHHLARHSVACFLTRGQLYISWERGAEVFDRYLVDRDPASNAGNWMWLSCSCFFHQYYRNYGTTTFPAKYDKTGKLVRKYVPELKDYPDKYIYKPWEAPEDVQKKAGCIIGKDYPKPMVDEKRASSECMAKMKDQYAKKLYGDSELKRKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFD9</accession>
    <name>I4YFD9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957345.1">
        <property type="nucleotide sequence ID" value="XM_006957283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFD9"/>
    <dbReference type="GeneID" id="18472864"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56843"/>
    <dbReference type="HOGENOM" id="CLU_903728_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFD9"/>
    <dbReference type="OMA" id="KTHRPSM"/>
    <dbReference type="OrthoDB" id="3355498at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="33924" checksum="EB8130B2F3A72A11" modified="2012-09-05" version="1">MSSLETRSSSPSDRFIKPHLPPLQHKRPSPPESDESDDDQFTFSPVHSPALNSGTFTSGHRKFVLTPAHEFYYRQKMLSLSRSQFATVSDYSAHVTAIVQKLMAAGVRLTESEATHAYIRGLPDVTAQAVLSSLENNTSFTKVQLLTHAVEEARSSAVMAGQYAAEQATEPVQNNRKTTASHRRVRYRSHSVTTQPTSNHLMTALTSTPQTTTMSRPRSIAFPRAHRPSISNVNDIFDNDKTPQAGTSLPKFTPLSPPSESLLSQTEKLSLCSPTRHKRTVQRSSPYASPTKRSPVKREGPFGLGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFG5</accession>
    <name>I4YFG5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_16511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957161.1">
        <property type="nucleotide sequence ID" value="XM_006957099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFG5"/>
    <dbReference type="FunCoup" id="I4YFG5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFG5"/>
    <dbReference type="GeneID" id="18470696"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16511"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFG5"/>
    <dbReference type="OMA" id="WVGRHEK"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="27205" checksum="C20639744F8E93CF" modified="2012-09-05" version="1">MPSSADIEYLKLLLSDSNLPTGGFVASSGLESFVGHGYLSETKLVDFLAFSSENTSRTTLPFIKAVYAILELETSIDEKIDRLIRLDRIHEAQMLNNVNKRASKAQGIAMLTLYTKSFGNDALIGRFKLLTRKAQTEGHLAICWALMTATLGLPLYDSQQLSLFLQARSVLSAAVRLNIVGPYAAQKVLLHDVRQLVEVAFEAHKLANVDDDEGDDVDDIGPATTWPLIELLSSRHDMLHTRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW3</accession>
    <name>I4YFW3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_31564</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956905.1">
        <property type="nucleotide sequence ID" value="XM_006956843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW3"/>
    <dbReference type="FunCoup" id="I4YFW3">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFW3"/>
    <dbReference type="GeneID" id="18471330"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31564"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFW3"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="27"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="696"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="948"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="976" mass="111199" checksum="A605FFE6005B6645" modified="2012-09-05" version="1">MTPKGDKKDTTKPMASGYNPVAVESAWYDWWEKKGFFKPSLDADGKPIGEVFVVPAPPPNVTGSLHIGHALTISIQDTLVRWNRMQGKTVLWNPGYDHAGISTQSVVEKRLWKSSGQTRHDLGREKFLGKVWDWKEEYQMRISNQLRRLGASYDWDRVRFTMDEKLSKAVIEAFCQLRERGIIYRSNRLVNWCVRMNTALSNLELDSKEISGRTLLNVPGYDEKEKFEFGVLTSFSYQVKGSDEKIIVATTRPETMLGDSAVAVHSSDSRYKHLHGKTLVHPFVDREIPIIVDDICVDPAFGTGAVKITPAHDFNDYEVGKRHNLPFINILNDDGTFNANAGDEFKGVKRFHARRTIVEKLKEIGSYVDTKDNSMVIPICAKSGDVIEPIMKPQWYVNCQDMSREAIERTRAGEMTIQPKHSEGDWYRWLENQQDWCISRQLWWGHRCPAYFVNIEGQEQESSDDKNWVVGRTLEEARERAEKIANGKPYTLEQDEDVLDTWFSSGLWPFSIMGWPDETQDMENFYPNSLLETGWDILFFWVARMVFFGITLTGQMPFKEVFTHAMIRDAHGRKMSKSLGNVIDPIDVIEGCELDALHQQLYDSNLDPREVKKALDGQKKDFPKGIPQCGTDALRFTLCAYTASNRDINLEISKVESNRKFCNKLFNATKFAMLKFPEGWTPAASAKPTGDESLVERWILSKLNYCAKQLDQDLTNRNFMSATQVIYNYWLYELCDVFIEASKPLTAEDADEKSRRSAQNTLYTALDAGLKMMHVFMPYVTEELWQHLPRRPNDNAESISLTEFPKADPAFEFTQEAKDFETAYGAIKATRSLATAYNVQGNNIQAYIETTEEKAPIFKSQLAVLKTLIKGCKVLEVVTTSSEIPVGCAVQSINVDANLHVLVRGLVDIDAELTKLEKKEKAAKMTLEKTIKATQIDGYAEKVSVQVQQNNQEKIQNYEKEIEALTSAMKTFASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW9</accession>
    <name>I4YFW9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956910.1">
        <property type="nucleotide sequence ID" value="XM_006956848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW9"/>
    <dbReference type="STRING" id="671144.I4YFW9"/>
    <dbReference type="GeneID" id="18473478"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59651"/>
    <dbReference type="eggNOG" id="ENOG502S49E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_866549_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFW9"/>
    <dbReference type="OMA" id="KEDTYHE"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35524" checksum="989D2DD6F69CB217" modified="2012-09-05" version="1" fragment="single">MFEEYTIRLKHLFKPKPKLEPPQPNPSEVLMGDSKAEVYQEIPISSNRDTKMSLVTIIIRSCQMISSMLCLIMWAATAGFQAKWDVGPSGLSGLSIAASLLFFILSVILFTIPMLYIKKNMAKNADLFLRERRSAWVLNGVGVFISLLMAAISTGSAFTTAGCKNPDDDPNEGKGDDFKDALPIFCGTKKTASILFWVVFFSWMGSIAEIMLNNKNLIKKSGRKSGTRDPPFQAPDADQEAGYGYAKETYQSDASNRTYDDSSAPLTGRTVNPFEPEPGNPYDRVSDNDDDNNPFSHPAISEPEFVYKPGMYSSSADAYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG39</accession>
    <name>I4YG39_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_6282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956838.1">
        <property type="nucleotide sequence ID" value="XM_006956776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG39"/>
    <dbReference type="STRING" id="671144.I4YG39"/>
    <dbReference type="GeneID" id="18474792"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_6282"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018832_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG39"/>
    <dbReference type="OMA" id="IAFIKHE"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="370" mass="41707" checksum="2BD48DC8CE049F20" modified="2012-09-05" version="1" fragment="single">NETAEQKNERTVFVGNIPAEAAKSKPLSKKLVRHLMEISDLPPTAKYDSIRFRSVAFSVPTSASAKSNADNKRYQTPKQKRKVAFIKQDLHPDAASVNAYVVFGYRRSNDVVLLNNKDKDIPPSEVAQKVVDAANGSTFEGRILRVDRVLNVDKTGTRWHIDKDMAKRTLYVGRLDFGQKDNELGEFIEKLLNEEKGTYKSKDADDKAKSWVRGVRIVRDPDTQLGKGFGYVHLADNDCVEELLLLPDERRRLNKRTLRFAKSKASGKQKPQEDAKEAEKKDKKDAKKSVTAKPGKIVKGDPNLGDKLADMTKEARKKTKAVDAVRQARRLAKKQQAVSKKQTDDKVKLTKTRKKPTDKKPAKNAKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG78</accession>
    <name>I4YG78_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycosyltransferase family 24 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_31631</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957012.1">
        <property type="nucleotide sequence ID" value="XM_006956950.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YG78">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG78"/>
    <dbReference type="GeneID" id="18471340"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31631"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG78"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698893" description="Glycosyltransferase family 24 protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="63"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="276"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="411"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="674"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1168"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1481" mass="169109" checksum="0A048FC9F68951CF" modified="2012-09-05" version="1">MLGRSVFLTALLAFASADIHAPPPISVDVQASWNQPPYCEIAMEIAHKLEPGILNKLLPKVDCSATPEEIYSKTRQQVKKSKQSLFDLHIALESSSPAIVAAYNVAEDAGFYYDPSCPNFVVYQGRKLCDVDEIDRLDQQAWPESDTFYTTGSTLDHVLSEPTSEDPPIIIHYADPTAENFKPFFDYFIKRSKRLQYILRWAPTRDHSFRPQKLSGWGVKMDLKKREYLSHDDRVNAEKINNIQTNVASDMSDEEYGVLQPFLKEAFTKPLQTIETKEDIRSLSGNLIALLQKSDNPLGLLTAITQNLPLLAPQLAETDLDGSNDILKELSYNQEKYIEAGQNAVWLNGRRLYDVDIEPFSLLRQLENENKLIDSISTLGFSKSDAIKLLNHRALYAAQVTRPDSIAEGLVDASDRIEGGDVVRWINDLEKDEQYRNKSWSPYLRSLLSPLGRVARNYINCVLVVDLSKNEAIEMLSRNVRAFIDRGIPVRWGVTPYINSLNDDSLMATKLFYNLIDKRGVKTCLDYFSDIAIRTGTFAERAEAAYLDLPILNDVPLQDEFDTVMEDMAKNKILKKAQKYARRLGVSPGEHEIDFIGEIFVNGRPIMFDDRLILSLQEHISAQTDAITKAVYKAEIDERSDVSLYFYDKPSTLKRRNKYLQPSSKIMNYVHSESDFFETTFVVPDTPERIDVTIWLVSDFNKPESMELIKHALSGMIVSPTFRLGFVHNPSELETPTGSISQTIKGLPERVSPLEFFEALQDRGEIPEDAEGMEGASEWIYETDIEPGESGLIVNGRVIGPIPPNGLEEEDYSHLFQYDYAERVLPIVTALEEIAPHRLKGNVDDVANLLTQLGSQLWKNIQNEQPEGIYEPPHTPRARVLERLHSKHTSIRLGKELSSQYSLDVILDPFSEQGQKWSKILHAIAEAGDTYIRIVFNPNLDSDKIAANRFYRFNMHAKPRFDENGHVIDYATKFSQMPVDALFTLELDPPQAWLTRPVYAPVDLDNLNLATAPYKNLNAIYQLDKLVVDGHARDSRTSLPPRGLQLSLKDTTIDTQVVANLGYLQLAVVPGRWELEIREGRGRDVYELESIGSAGWNSPSVKEGLKDFIVDSFEGVKLYPRFLKKPGMEGIDVLSEQHEDGLLPFVKQSITSLKSFFGLRSKSEHADINIFTVASGLLYERFASIMILSVLKHTDHTVKFWFIENFLSPSFIEFLPHLAKEYNFKYELVTYKWPSWLRPQKERQRMLWAYKILFLDVLFPMSLDKIIFVDADNIVRTDLKELIDVDLHGRAYGYPPIGMDRQEMDGYRFWTRGYWKDYLRGRNYHISALYVVDLKRFRQMAAGDRLRGQYQGLSADPGSLANLDQDLPNNFQTEVPIHSLDKSWLWCQTWNSDESLADAKTIDLCNNPMTKEPKLERARKIPEWTDYDRDIQDFSAKLASEKLIKSLLVTETEDLAQGPKVTWEEKTEEGDIKNNHLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG88</accession>
    <name>I4YG88_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957021.1">
        <property type="nucleotide sequence ID" value="XM_006956959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG88"/>
    <dbReference type="STRING" id="671144.I4YG88"/>
    <dbReference type="GeneID" id="18473510"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59710"/>
    <dbReference type="eggNOG" id="ENOG502RYE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007340_4_3_1"/>
    <dbReference type="InParanoid" id="I4YG88"/>
    <dbReference type="OMA" id="VSSHEMA"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="851" mass="96162" checksum="C6E7FDCA5EC530F0" modified="2012-09-05" version="1">MDNMYQSINDKDKVNQKKRSRQLLSCGECRRLKLKCDRVWPCSSCKKRGCAAICPEGTLKGGTMSRNALVSNTASLLSRIEQLENALKNVGEIVPPPTEPIISSAAYAFNSPPPLQEQSFQEEDFAESFGSLTLGISGQARYVGPSAGSEWLQNEDAISDEDLESERRNESSPNFQDSPNTPPSDFPFPGATNQSVVEEIWRQLPPIETARHLSNKYWDYDSCLYYVVPREIFDEDFEIIYQGLIDVKFAHQLARLYMILAIGLHCDVYAPFGHPDCHKYYCSAKTLLNASDFMTKCSLATAQTLHLMGSYLLNRNRISGADSYWPLLGVQMRIIQAMGLHRDGGRWGFDARQLNERRRTFWECHTIDVFQSICFGRPYSTHARHIDCDFPIDEEARNFHTGGKDEGYGFHTLKFKLVKHLCRISDDIYGVNPPPYETVIHVDRGIREFDKNIPSHLRCKAASLVRNSSNYPIEEEDSNNISDKLALQQHTLALNVNECLLYLNRRYFAHALKTHPEDPLRSSFAQSYIAVMECCRVIVALVRSIHTLLPELSTRYWYFFHHLFSCGVCAAASCMLSPGSSMAAEAWKDLNEIIELCALPTAGKRANAFVPRLTQLREKALDRRKAHLESRVMIGNKEEQENEEDHLVLLGLGSRVVKKGHKPHVTIPSRARSYSTQYNLAGGNAQYNQPGIYSPSSDKGVPAKSFNEYAAISPEDENSRSKSRRRSRFENTSRNDNDAFINSPSFNGNFTFQAPNANDPVYEALLQTSSGTNSTEMFNSLWDFSNNNKPIPDLNSTNDNLNTSLNNVPIDPFFTGMNAVNNNWTETNERNQGDGRHNDADWSNIINSMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGG8</accession>
    <name>I4YGG8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957094.1">
        <property type="nucleotide sequence ID" value="XM_006957032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGG8"/>
    <dbReference type="STRING" id="671144.I4YGG8"/>
    <dbReference type="GeneID" id="18473535"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59753"/>
    <dbReference type="eggNOG" id="ENOG502S6YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148782_1_1_1"/>
    <dbReference type="InParanoid" id="I4YGG8"/>
    <dbReference type="OMA" id="MLWAKQY"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="10352" checksum="18FD74E0F5CD7167" modified="2012-09-05" version="1">MGGGAQFPVPKDVWTPAGGWWTNPRNWKANTAVVFTAIGFLTYGVWNYSASKENRTREPSRWIPSMIWAREFKEGKLGIRKEEYTPAQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGP7</accession>
    <name>I4YGP7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_67453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956538.1">
        <property type="nucleotide sequence ID" value="XM_006956476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGP7"/>
    <dbReference type="GeneID" id="18475257"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67453"/>
    <dbReference type="HOGENOM" id="CLU_642735_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGP7"/>
    <dbReference type="OMA" id="HKEAMIV"/>
    <dbReference type="OrthoDB" id="3204217at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024318">
        <property type="entry name" value="Nro1/ETT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290:SF1">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12753">
        <property type="entry name" value="Nro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="381" mass="41851" checksum="24DEAA5707E98D8F" modified="2012-09-05" version="1">MAPKRPAGLGAASKAKKNKQEEPNKEERSNVVPPTQEDTEDGDDWLDLLELWEKCKTSLNSNEPASSAPLLRGILHETSRLVDLNGTDLSGFKSVSENGEELQVSVSHFRLILASALLELGILISASARFNEKDSLAAEGEPKTGSPFFFRAYSVAKTVEDQVFIEDSELVAGRCAAEYLKERTASGETSNDPDDELKEESNQQLLEIATESISKCNLDTKSPTLLLSLGSLLSTLEEDIINIENPSTALSIFETALKKADNTQTKFELLIGKARVLVSRGGYVIDKLFDEEDPSGKSKVEGYVQQTVNELRVAINSLEEAQNMSDDLEVGESEANELTSLLKEAMIFLANLLPEGEEQEELFKKAGVEDEEEDEEEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGT7</accession>
    <name>I4YGT7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956573.1">
        <property type="nucleotide sequence ID" value="XM_006956511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGT7"/>
    <dbReference type="STRING" id="671144.I4YGT7"/>
    <dbReference type="GeneID" id="18474762"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62552"/>
    <dbReference type="eggNOG" id="ENOG502S9QR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063099_1_2_1"/>
    <dbReference type="InParanoid" id="I4YGT7"/>
    <dbReference type="OMA" id="IIECQPA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698911" evidence="2">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="206" mass="20830" checksum="EADF7F82204E73E9" modified="2012-09-05" version="1">MKYIAATSALLASALAAKITSPPQITQCRNIAIKWTEGEGDIYITVIPAGEVAAEPLEAFPKQSGSTGTYNWKVNVPGGQKISLAVNDESGDVNYSSELTIRDSDDDDCLGKAAESGPANTDDKDSSDDKDDSDDKDDKTSSSSSSSSSTSSSSSSSSAKSSPTSGSNSSSNNADSSAQDDDSGAVSHAVAGSMVAAASLVGALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGW6</accession>
    <name>I4YGW6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_15277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956500.1">
        <property type="nucleotide sequence ID" value="XM_006956438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGW6"/>
    <dbReference type="STRING" id="671144.I4YGW6"/>
    <dbReference type="GeneID" id="18470655"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15277"/>
    <dbReference type="eggNOG" id="ENOG502S7T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105491_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGW6"/>
    <dbReference type="OMA" id="DRISQYM"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="16088" checksum="0966872BD6568242" modified="2012-09-05" version="1">MTKPVDYRGAVVEDLDLQPALTVYANESIDKVLIAAYEREFSQVPVLNDESNKKIIGYIDVEKLLKQDNDHSKSVNDYTIRFASKNKRFRVITPYTPLEELDSFLIDNEFAIVTDQQRKFVLGIATRGDLSNFRKRRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGW9</accession>
    <name>I4YGW9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_67512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956603.1">
        <property type="nucleotide sequence ID" value="XM_006956541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGW9"/>
    <dbReference type="FunCoup" id="I4YGW9">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGW9"/>
    <dbReference type="GeneID" id="18475261"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67512"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141947_2_0_1"/>
    <dbReference type="InParanoid" id="I4YGW9"/>
    <dbReference type="OMA" id="GTNDEAC"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="8">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="103" mass="11439" checksum="3C3778A67F092A06" modified="2012-09-05" version="1">MGFGNPSTSNNIFSITPPARGSFPLDHDGDCTKPMKEYLKCLKSNRNNNGACRELSKSYLKCRMQNGLMENDNFDNLGFTGVSDPTENKTQSKSTHTSTERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGX3</accession>
    <name>I4YGX3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_62589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956607.1">
        <property type="nucleotide sequence ID" value="XM_006956545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGX3"/>
    <dbReference type="GeneID" id="18474764"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62589"/>
    <dbReference type="HOGENOM" id="CLU_1367185_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGX3"/>
    <dbReference type="OMA" id="GNIQCNT"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="200" mass="23358" checksum="5C62FE19756686C9" modified="2012-09-05" version="1">MQRHLGLLVKNLPPHLPSASIKQFFDKYAKVSDIYTFRRSPFGGHTGQSLIHFENAVELNKALKLNGRSLKDYKLIVEPTVEAAHEIDIPIERPVRTKFRSQLLYVTGQPLDSTEEELTRAFRKFGTVRWIEQSHQDRKKFAFAYAFVMYESPDFATKAYENGVYIRDNIKLKISFFKRPIKYPKDGNFSFQDKAGKRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH41</accession>
    <name>I4YH41_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_15609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956514.1">
        <property type="nucleotide sequence ID" value="XM_006956452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH41"/>
    <dbReference type="STRING" id="671144.I4YH41"/>
    <dbReference type="GeneID" id="18470669"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15609"/>
    <dbReference type="eggNOG" id="KOG0080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="I4YH41"/>
    <dbReference type="OMA" id="RVHKMDV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23030" checksum="8CD5A8E51B8CD47E" modified="2012-09-05" version="1">MTDTHSVTSISTRNEPLQAFKLLLIGNSSVGKSSLLLRFTENDFLPEEDANATIGVDFKVKYIQIKDKRYKLSIWCVFATHTHANFNTAGQERFRSLVSSYYRGAQGVILVYDVTNRETFDKLRVWFQELDTYSTDDAVKIVVGNKTDVNHQRAVSIEEAKELAELHNAMFVECSAKTSTGVNHLFYELAQKVSPNYRYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE0</accession>
    <name>I4YHE0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956763.1">
        <property type="nucleotide sequence ID" value="XM_006956701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE0"/>
    <dbReference type="STRING" id="671144.I4YHE0"/>
    <dbReference type="GeneID" id="18473438"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59585"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152503_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHE0"/>
    <dbReference type="OMA" id="AEPHHDH"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23130" checksum="CCECDC0642B234E5" modified="2012-09-05" version="1" fragment="single">MIEINNEELLEVHAQSLASQSFLARSDHFVMGDKIKVLDYGCGSGVVSESLQFNSNSILGVDKNVNLVKEFNQKFQSRGVPIDKLQATTEIPKTSKFDVIVCTQLLHKVKDIDSEINKLSNHLNKEGELLIVDYCDQPFSHSAVLNSTFTGDHIDPPENNVQPHSSAIPSNILQSAIHKAGLIDYSYRPAFLLDYKQNKIPFFIATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE5</accession>
    <name>I4YHE5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_62753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956767.1">
        <property type="nucleotide sequence ID" value="XM_006956705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE5"/>
    <dbReference type="FunCoup" id="I4YHE5">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHE5"/>
    <dbReference type="GeneID" id="18474786"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62753"/>
    <dbReference type="eggNOG" id="KOG4759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042823_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHE5"/>
    <dbReference type="OMA" id="PRIICTR"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="113"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="267" mass="29206" checksum="0685E143CCEFE03C" modified="2012-09-05" version="1">MSLSSRAFKSPIGKSLQTRTISSTTQLLKKKAPKSTPSKSTKSDAALADTTVVLPTKGKKVGKSRDWDEAQVETTHQEDEAEGSFDLSFNDFTNKQKEIVNKTKEDLETLVNRVGRVTPDLLDSVSVEIDKELFNLQSVASVSVKDGSSLIISVFDASMIRDVEKAIFAANLGLTPQKISENVLKCLVPRPAADTKSKLAKDAAGIAENARIALRLRRQALQKIVNKQKTGKSTNDLRTIDKMMDEATITHSKSIDDLLHKAQAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG2</accession>
    <name>I4YHG2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31487</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956781.1">
        <property type="nucleotide sequence ID" value="XM_006956719.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YHG2">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHG2"/>
    <dbReference type="GeneID" id="18471312"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31487"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHG2"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="508"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="932"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="981"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="981"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1036"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1210"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1236"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1460" mass="155711" checksum="8C5309448D296733" modified="2012-09-05" version="1">MPHTSIIRTSTFAWSPFSNGCTIATGTVAGALDENFSNDAQLELWDAFSSETPIVKGSVTTNSRFNRLGWGHVNSSRPNGVIAAGLESGEIAIWDPQLIVNDPTNSLLHSNSSHTGSVKGLDFNQLQSNLFATGASQGEVFIWDLNNPSKPYHPGPKSQKLEDITSTAWNAQVPHVLASSSDSGYTVVWDLRHKKEVVGISYGGGAGTMGGPFGNSSAITQQGRRGISAVAWHPDNATRLVTASEDDTSPVIMLWDLRNARAPEKILTGHDKGVLSLSWCRQDPDLLLSSGKDNKTLAWNPNTGENIGELPTSNNWSFEVEWNHRNPDIFATASFDGTIGIHSIQSQTPSPESIAANVQQAIDPNDIFGAVSAQQEAEQNALRAQQSFSLKQAPKWLRRPTSVGFGYGGKLVTLKNNLVQIHQLSTEPSILERAKILSEAIDSPDGESKLINLCQSQVDKNGGDCDTWKALHSLFEANSRDQLVQLLGFSKEEVAKQVQAAIDAFPKPAEPTVESTQISSITSDAPEKESTVSFVEPESKAEDETAEEPKEEENKPEETKPEESKPEESTPQGEPQESAPGDSLFGDSKPDGDDFFRSVAVASESTPQAENVVVPHTTADESVAATVGSPGPSSIASEAMKANTFKIYPSEESESDRLITKALVLGDFESAVELCLSTERYADAILLAVKGGSELLAKTQKSYFQRQTAHLPYLRLFQSIVSDDLSDIVQNADLNEWQEIFVVLCTFAKSEEFGQLAEQLGQRLDFQYRVADEADKLGAKKYRTNAILCYLAAGKLERVVNIWSDEMLEEESSGVGEHTSKQSQHALALQSFIEKVTIFQKATGYVDQDLNQPTESPTVAASGVRVYKLSTLYDRYHEYAELLASQGLVKDAVKYINLTPVDYKGAAGASSDAQTARERLLIAASDESQKEARKAAAAEQEAQQEAQQQAQAAAQEQMKAQQPVQSTSAYAPASVAQAPLQQAAPSYSSPYAPQTNSNPYAPPAQTQAYNPSAQQQTVQQPQAPTYGGYAPPPQPTMHAPPVATNPYAPVVPAPTTAAATAADTYNPYNAPAGVAPPVSVPEPATSQTLPPPPPQRTAVPASQRRDLSGWNDAPPPPPPKRGTTPSNTGSRASPIVQPLTSPFPNSSPVPTPGIGGPPQAGSLVPPPPKAGTKSMPPPPPAASSIPPPPPKAPPAAGPPMTSPMVSAPAMAPPPATGPPMTAPPAAVPPPPPAGPPAGRMMSPSFGQQAQTPQPPAGPPQVQSFGAMANGIQRPGSVNAGGYRQTPPPPPPHLVQQAMQQQQQQRSVISPPPVSSPPVSNVAAYTVSRPGSVASTRVSEAPAQPSFPPGDRSHIPPADRIIFESLSREIEKAKSRSMAQPQTKRMVDDTQNRLNALFDSLNAQTVESQAVLNNLRNVSQALSAQDYNTAMKITLEIMGSGEADMRWALGLKQLIRLTGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI4</accession>
    <name>I4YHI4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Cmp1p</name>
        <name evidence="17" type="ORF">WALSEDRAFT_59605</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956801.1">
        <property type="nucleotide sequence ID" value="XM_006956739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI4"/>
    <dbReference type="FunCoup" id="I4YHI4">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHI4"/>
    <dbReference type="GeneID" id="18473451"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59605"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_6_1_1"/>
    <dbReference type="InParanoid" id="I4YHI4"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM23426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="660" mass="74057" checksum="190058EA38C86F48" modified="2012-09-05" version="1">MSSQQERIQNALAQMSSKPVPDIDFTVHTNEDGTQVSTQERVIKDVQAPAMQPPTDEQFWSKVDPTKPDIAFLKNHFYREGRLHEHQALYILHQATEILKNEPNLLNVDAPITVCGDIHGQYFDLMKLFEVGGNPVDTRYLFLGDYVDRGYFSIECVLYLWALKIWYPNTLFLLRGNHECRHLTDYFTYKLECKHKYSETIYDACMESFCALPLAAIMNKQFLCIHGGLSPELNTLDDLRRIDRFREPPTHGLMCDILWADPLEDFGNEKSSDAFMHNHVRGCSYFFTYTAACQFLERNGLLSIIRAHEAQDAGYRMYRKTKTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNICSKEELEEEEEEEAAIEAAAIAAANEKVVPEPEIPSVQVQEAETEIKAPPKIVTSNEASQDEMAAATSDLRRQIVKNKIMAVGKMARVFALLREESEKVSELKALHNTNKLPSGQLALGAEGIKEAIENFDDAKKSDIENERLPPDLVDADIDAPASPAFSQPGTPTNIDEPLSYSAANGVGSPMSPQSGPSSPASIGSSPSIGPTIGHGHSQSYAYTPSTPFRRGHHARQQSLGTTSTSPSNRRRSLDQTISLIREAMDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHK9</accession>
    <name>I4YHK9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-dependent phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956823.1">
        <property type="nucleotide sequence ID" value="XM_006956761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHK9"/>
    <dbReference type="STRING" id="671144.I4YHK9"/>
    <dbReference type="GeneID" id="18471320"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31518"/>
    <dbReference type="eggNOG" id="ENOG502QW39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_2_1"/>
    <dbReference type="InParanoid" id="I4YHK9"/>
    <dbReference type="OMA" id="RVYAGCG"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698175" evidence="1">
        <location>
            <begin position="23"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="158"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="391" mass="42693" checksum="B4513CC118477126" modified="2012-09-05" version="1">MFNKLITKAALSLGLGVHTAQASSQVEDLSGPHAISQLVADRGFDTPFYINDDHSPKFQVFDEAFKNILGNNPSIQSIAKSYDPDFNAFHEAPLVRGDRVYFSSNAGDGGSGPDLNNRLFYINLKDIENNGVDTNITVTYVNPSDQIQMINGMQPYLDNSIIIATEGRENAGVAPGLFRYEPETNTTTPLLTSFYGRTFNSLNDLKIHSSNQIIFVDSLYGFLQDFSPFPQLPEMVYTFDINTGKVRPLASDFVHPNGIALSPDESVAYVTDTGAMNGTVNTHLPASIYAYDIINDDGFLTFRNRRLFAHALTGVPDGIHCDDQGNVWSGVGDGVSVWDKRGDLLGLINVGTTSANFVIVGDGLVIVLAETEMFAVRLDSSVNPAKLHYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHN6</accession>
    <name>I4YHN6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase, alpha subcomplex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956157.1">
        <property type="nucleotide sequence ID" value="XM_006956095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHN6"/>
    <dbReference type="STRING" id="671144.I4YHN6"/>
    <dbReference type="GeneID" id="18473231"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59217"/>
    <dbReference type="eggNOG" id="KOG3426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111660_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHN6"/>
    <dbReference type="OMA" id="FWKQTTH"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="14710" checksum="456AFD88B5A1C9F2" modified="2012-09-05" version="1">MTTIPSRLAHVTKSSTSFAEAHARARTLYRDFYRSAPSICALYSLNIPPSQIRAKIRQEFEKNRNLDDLNVIDLVLFKGRQEYQETMNAWKQETHIMRWFALEEAPPRPQTFLEKFYAGRDEDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI45</accession>
    <name>I4YI45_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956305.1">
        <property type="nucleotide sequence ID" value="XM_006956243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI45"/>
    <dbReference type="GeneID" id="18471255"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31127"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="InParanoid" id="I4YI45"/>
    <dbReference type="OMA" id="KWNSMSY"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="511" mass="57955" checksum="8450D6489ACBE238" modified="2012-09-05" version="1">MGCKLKATVGIDDFEIYEREPEVGGTWYINNYPGCANDIPIIVYSFSFAQKDWGNSQWAPQPRIEGYIRDVVKDFNLSDHIHVKRTMLNANWNKEKEYWVVTIKNNETGEIFTRTSNILISAHGGLDVPRPIDTPGIETFKGDILRSQRYDQTVDLTGKNVVVIGNACTATQIIGEIAPKVKTLTQFARGKQWFLPKPVVHLGHPVVRWMLKYIPGLHTALRGLVFGVVDYFMKAMYVKNGEATRKKRMETSKRHVKNLAPAKYHDALIPDFQIGAKRRIFDEDYLKSLNYDHVDLIAERPARITENSVVRQDGTEVPADVIIYAIGFDTTTNKFLENFNNNGLNLRQHFANVGTGAYLGAAVAPLPNFFLLGTASPNCASGHNSVIFTSECTANFIIRVIKPIVYAKKGTVHVTKEAERKYQEWIREKHQEMIWETENVGSFYLDNNTGKNTALYPRSHTHYWWSTLIPKDSDFVYENVSKPWLLQFTSKKAMSAYGTALVAGTATWFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI57</accession>
    <name>I4YI57_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_62316</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956317.1">
        <property type="nucleotide sequence ID" value="XM_006956255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI57"/>
    <dbReference type="FunCoup" id="I4YI57">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI57"/>
    <dbReference type="GeneID" id="18474736"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62316"/>
    <dbReference type="eggNOG" id="ENOG502SCNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118180_3_0_1"/>
    <dbReference type="InParanoid" id="I4YI57"/>
    <dbReference type="OMA" id="MEHASAH"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="9511" checksum="668CAA7BE9896CC5" modified="2012-09-05" version="1">MSDENRVNELETQVLQEYSSIAQTMKRFNQVCKELSHNPNEQLLQQLRQLEQKMGLVLTLYKASVWSVIMDEQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI95</accession>
    <name>I4YI95_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_67313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956353.1">
        <property type="nucleotide sequence ID" value="XM_006956291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI95"/>
    <dbReference type="FunCoup" id="I4YI95">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI95"/>
    <dbReference type="GeneID" id="18475238"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67313"/>
    <dbReference type="eggNOG" id="KOG4080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_0_3_1"/>
    <dbReference type="InParanoid" id="I4YI95"/>
    <dbReference type="OMA" id="ANCYSYI"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="83" mass="9357" checksum="02C1B332AEFDC735" modified="2012-09-05" version="1">MLSLRINNFITGNLLEDLLGSILRAVPKKKVSHSRKAMRSANKGLRDKNNLVHCPASGLPKPAHHLSQELYSQLKRNWKSSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4YII0</accession>
    <name>I4YII0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_31260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956435.1">
        <property type="nucleotide sequence ID" value="XM_006956373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YII0"/>
    <dbReference type="GeneID" id="18471271"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31260"/>
    <dbReference type="HOGENOM" id="CLU_2887543_0_0_1"/>
    <dbReference type="InParanoid" id="I4YII0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="63" mass="7193" checksum="5BA3B1810D5DE4AD" modified="2012-09-05" version="1">MKANLMRFKRYQYSIKHVSIASYLDIICMPCETTVIGCVCIEIENNLELNDAYPHNGSTLNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIW6</accession>
    <name>I4YIW6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_66795</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955749.1">
        <property type="nucleotide sequence ID" value="XM_006955687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIW6"/>
    <dbReference type="FunCoup" id="I4YIW6">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIW6"/>
    <dbReference type="GeneID" id="18475153"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66795"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIW6"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="730"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="983"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118285" checksum="271A3D25DF0104A1" modified="2012-09-05" version="1">MGVKGLWQLLQPVARPVKLEMLGGKRVAIDSSIWLYHFLRAIKDKQGHTLTNAHILGFLRRILKLLFYGLKPVFVFDGGAPRLKKTTISERKNRRQGARQSHALIASRLLSAQLRKAAIQQQQRAVQSKGTAKRSDDSDNDDNVAYLDDLNNVAPKKQTPQKKRRLDPYELPAVPSHPKSNIPDPRLATEDELRDFISTMKPSDFDTSSEAFKQLPPEVQYELIGDMRLKSRSTSFSRLETMLRKSSTAKDFSKAQIQNLMQRNDLTQKLINHSEGMGKDEESPVALRVSTSRNKEYFLMRKSDNEGGGWVLGIQDSRGQPGQKPIEISSDHEDGEEQHISEDTDEDDMDMEEVSIPPAEVSDVPAFNEDGSQIPHVYDTFEENEAQLTGLDAALDESMITKAKEDSLRMFTEMARRHREKEKATDSIENQPDSLKDVRGVSNAQATQKLGQMQPNVTRTITKPPEQPSSQRKATLKHTPARPQEEKREKLKLQDFQSRQSKRLPERKSVTPEDQTPLFLDEDEENDVADMEEVAQIPSVDYQKKNYVSEPIDKATSEKQIDIVKIEKHDTDLNLPQGQGAIFKEPHKAPQKELLDSDVESAYSGWEESPPPQQPPQTTTSASVSQSTSTQNEKQLDELHLKDRSSENKEMSPPIDIDASDNEIEAIEAIENEEKDYIAFSSTVNNKNYDEMLAEADLDIRRLQQSAKKMSGGSDDPTMQMTGEIQKLLRAFGIPYITAPMEAEAQCAKLAQMNLVDAVITDDSDVFLFGAPIVYKNMFNDRQFVECYVSSDIERDLSLSRDRLIELAHILGSDYTNGFPGVGPVMAMELLADFAHENTLVGFRDWWIKVQNGKDTSNDTSTRFRKNFKKKSKNLFLDKEFPDPQVKGAYYGAKTDSSNEEFVWGIPNLDELREYLYNYLGWPAHKVDDTIIPVMKHMRNKKAAPQTSLDRYFDDTVGAGVLGPRPMAAYSSNRLKEVVKAFRGRNNSETPASSGSDSEEADSTKKKKKQPAKPRKRTQKPARVASKRKKDTSEEDEASDWEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ58</accession>
    <name>I4YJ58_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_66873</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955834.1">
        <property type="nucleotide sequence ID" value="XM_006955772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ58"/>
    <dbReference type="STRING" id="671144.I4YJ58"/>
    <dbReference type="GeneID" id="18475169"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66873"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336226_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ58"/>
    <dbReference type="OMA" id="FKEIERW"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="511"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM24000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="848" mass="97240" checksum="8DA8AD5B8534CA53" modified="2012-09-05" version="1">MNDSRDENNKNKKLLSTYHRFKGCSLLDQEYTLADKIGQGTFGVVFKATSKSTKQVVAIKKILIHTAKDGFPTTSIREISFLKLLNHRNIVQLVDMSFSKENSNPMFYMVFPYIDHDLTGLLERQDFNPSTSQIKLYMLQLCEGTAFMHANGVLHRDMKASNILISNDGSLKIADFGLARICHKLQQKNSKSKSRNYTNMVVTRFYRPPELILGEKNSWGDYGPEIDIWGLGCIFGEMFTHKPILQGHTDIDQLKRIFELCGDPTSESWPGWETIKGQYSIDIKTFGYKNGNLKEKFMRYNNFDLSALELLEKLLTMDPKRRISAKDALKLDYFWTKPLPMKKEDVKPLPSSHEYDSRKQMQAKQYTSTQKARPPVNTQMQQPYMSQKMPSSGSQFSSRPLPAYRPPGGQFSARPAPPSGFRGSHQRGPRPPSDNPYGRPSTNQMNTAQNPPINPYSAYSRSSHGRPPVQGRPFGNDRRSQPAQPPPPRFSKPRDDDIVVDYGAPDYGPSDGRKRERREPSPRRSLERPVNRRPDEKKEDRRSDVLPKAENGQPPPPKQLPPKQNIPPPPVEPKDSPARSGSVRDSKVSLVPPDSAGEERMSIDLPSRKENINRPEDPAGTSQTKGIARRPSMTKNSESLNQRRGSKDSRDDRDEYSRYDARNPYDRRDRERDWDRATDYGNNYDYDYDYDYDRGGNYADSGYHRNDRGYRPMNKKPRYDSRAEHRHHPDSEYAYKQQSGQGGFNRERSHYRGAGPRHGGISRTQPYQPYPDHDRTPMDLPSRPTDSGNPDEKAVNESRNHYTHDIQRGKTDNDANNTSHRNDDTYTRPRAHTSHTERHQNEEGEIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ61</accession>
    <name>I4YJ61_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_26731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955837.1">
        <property type="nucleotide sequence ID" value="XM_006955775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ61"/>
    <dbReference type="GeneID" id="18470949"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26731"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="I4YJ61"/>
    <dbReference type="OMA" id="DNEYATC"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="469" mass="52654" checksum="3EA9335F5F058B3F" modified="2012-09-05" version="1">MAFSLIPSSIPSIKLQLSVYILNYIDRNNVPAARHQGLEDDLELGYDNRYETVLSILYAGYIVCQVPSNGIVSLISRPSLYIGGAMAIWGVISCLTGITQNYVGILLTRLFLGFVEAAFLPGAIFLLSKWYKKDELGLRITLLYCGNLLSNAFGNLIAAGIINGMEGKLGHRAWRWLFYIEGALTIFVAVCAVFILPDFPETEYFLSPLERKLAVRRMAEDAGKVDTVMDKHEVLRGMKMALLDYRVWWLALTLFGIVTALSFNIYFPTLTEEMGFEGITALLMCAPPWIFATIVAFPWAVSSDRFQERTFHILVSNLVAIVGYIIAIATQNKAARYFSLFLMTLGYCGLICVYAFTSSSFIRPTSRRSVAIAFVNAFSNIGNIAGSYIWDADKFGPSGYRQSYAICIACTGFSCFLILGFRYILVNLNKKIEKLEEEYPGMDPWDIPEKCDRKLDNALLVKRGFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ71</accession>
    <name>I4YJ71_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_66883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955846.1">
        <property type="nucleotide sequence ID" value="XM_006955784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ71"/>
    <dbReference type="STRING" id="671144.I4YJ71"/>
    <dbReference type="GeneID" id="18475172"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66883"/>
    <dbReference type="eggNOG" id="KOG1378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="InParanoid" id="I4YJ71"/>
    <dbReference type="OMA" id="CKDVFEP"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005136185" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="414"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="486" mass="54620" checksum="F197D41F4CEA9668" modified="2012-09-05" version="1">MFLPLFSLLGATAASSLTYQQRLAYAGDDGVNIAFNTKGNNTLHSTPTVFYGTSKDDLTMQAQGLSSIYQTSLSTTHKVKLRNLNPDTRYFYQTCLDINNECPRSDVLSFKTTVPAGDQREFKFAVLGDMGVMGPLGLSTEAPSKVEDYARLDEGERSTMKALIDNKDKYQFIVHNGDHAYADDAGKEITAGYIEDIPDEPLLQQMSQTYELILETYFNQTSQFASSTPYMVGVGNHEQLLTEGKEYTDPETGEKILIDDIPKGQRNFAFYKDRYFMPGDESGGLDNFWWSIETGPLKYIQINTETDLGEGVKSPDEKQDPAQVNQGEPNQQIKWLEDQLKNVDRDVTPWVVVAGHRPWYGSLDDCEGCADIFDPLFTKYNVDLVLHGHIHLYERLAPISGGKKDNNGLNNPKAPWYIISGAAGHYDGLDEMPDEINENSEKIIQGEFGYDEITIHNRTHLTHAFIASKNDTLFDVQTLYKAHKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJQ9</accession>
    <name>I4YJQ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_30908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956020.1">
        <property type="nucleotide sequence ID" value="XM_006955958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJQ9"/>
    <dbReference type="FunCoup" id="I4YJQ9">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJQ9"/>
    <dbReference type="GeneID" id="18471207"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30908"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJQ9"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="178" mass="19834" checksum="77C14C42DB96D564" modified="2012-09-05" version="1">METLFSESLIPKSVASTLPAGYSIRPLSPSDYDNGHISLLTVLTKAPDPGRQAYMQRFYFLKNIPDTYFTIVITDNSGKVVGCGTVFLERKFLRGLGVVGHIEDIAVDKNQQGKSLGKKIILALTEIAQARGAYKVILDCSKENIPFYEKCGYEHKEYEMVYYTSPDTAYQSTSPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJT5</accession>
    <name>I4YJT5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956045.1">
        <property type="nucleotide sequence ID" value="XM_006955983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJT5"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_91_2_1"/>
    <dbReference type="InParanoid" id="I4YJT5"/>
    <dbReference type="OMA" id="MLTGEGY"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
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        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="359" mass="42184" checksum="46A5355C0E291111" modified="2012-09-05" version="1">MRTHNGEKPFECEICKLRFTREHHLNAHSRTHKSEDEKPFSCDICHKKFWTNQHLQRHLKTHTSSCICEICNKGFPKQFQLRNHMAEEHHPSGTLPFICTHPGCDKSFVSKPKLDRHARVHQSDRYSCGHPECLHLTFSKWTELQAHIKQSHKATCPYPDCRKVFSDRHNLNSHLKLHEQREIEKQIGIEDESAKIRGGIIGRDYKCEVEGCDKAFKSQKSLNVHVNTTHLNIRPFQCDSCEKAFGHKHLLARHMKVHKKEEETVDKTEDKMTVEEFTGVAYQKRTISCPYLKILELDNLPHCPFKYTRRYDLRRHLKAQHGIDFTKQELNYWLDGHVEEDSEEGGDDEVPETHEDIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK28</accession>
    <name>I4YK28_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multi-copper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Wsmco3</name>
        <name evidence="12" type="ORF">WALSEDRAFT_56081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK28"/>
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        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK28"/>
    <dbReference type="GeneID" id="18472768"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56081"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="InParanoid" id="I4YK28"/>
    <dbReference type="OMA" id="CHIQVHT"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697782" evidence="8">
        <location>
            <begin position="25"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="69"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="273"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="504"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="664" mass="74632" checksum="CA214A2B11008670" modified="2012-09-05" version="1">MGGHKYKKALHALAILCLANGVTSQTQQSSWNDWQEDIQTPIHNMRPQGDGKGGNTRHITLDITDQLEALDGGKERLVYAINGRPFNGGEPIFLEEGEEVEIELNNFSDQLNTSTTLHAHGIEQIGSQFNDGVPGVSQNVIKPGESFIYRWRAEEHYGLYWLHSHFAGVYQDGQAVPLYIRPKEDRKNPFDVIADDEDEVKALKRHDQDPQIIMISDYMEINNWEMKEKMEEWQSELLCINTPLLNGRGRVNCATSENLQKWTESNTTTDKGCVDRSLRPGSENITFDEELWYTCTPTDVEVPTYEFDYETGWGIIHFVNAASHWQYMISIDEHELNFFAADGSYVKPVKGDAFTIGIGERIGVAFRLHTPGEYVLRVSAHDEPQVVGQFGIIRYGLDDDDDSVEYSDPDSEDDPGMPSIPLSEPWINYAGQPVSDDVRVMNNSVTALKQFAPAEIPKRGEAADITLHFTLSNSNFLKWSFSEEGKVEYYNSSKEYQEPPILYDMESYMDDSSISTFPSGSVVDIIITNEERYNITGVAHPLHKHFEHYHVLAAGVGNFTYQDVIEAEDAGIEVNWLDPSYRDTVMIPASPAESASYLVLRYVSVQPTASLIHCHIQSHSMSGMAYVLIASDEGGTPDLPDYYSIKAFNTDLTDAANTVKQGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y507</accession>
    <name>I4Y507_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668270">
        <property type="protein sequence ID" value="EIM19049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960905.1">
        <property type="nucleotide sequence ID" value="XM_006960843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y507"/>
    <dbReference type="GeneID" id="18474665"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61661"/>
    <dbReference type="HOGENOM" id="CLU_2177209_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y507"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="110" mass="12411" checksum="86603B93E32A95E5" modified="2012-09-05" version="1">MQVEREFIPLHIPTPHTVFIHSDSLAVLSAIVQLQTTKTGQYLIKQVLDKIERIKRMEGREKTIVQLNWIPGHTAIYGNELADGTANEGMPTCAHHTRIGFALRTSYSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y539</accession>
    <name>I4Y539_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_34286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960865.1">
        <property type="nucleotide sequence ID" value="XM_006960803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y539"/>
    <dbReference type="FunCoup" id="I4Y539">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y539"/>
    <dbReference type="GeneID" id="18471850"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34286"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y539"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="233"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="335" mass="38347" checksum="C6A8329BAE793BC7" modified="2012-09-05" version="1">MEPDDEDHKENIEMDEQGDTFNRLRKNQDSYDPDQDRNLKRSIRKGYRSLIDRAEEHSVDVANVTAKELSAEMIKANDLYDSVRAPQEATLDSHFLIVQSEMSAAKARAMKIDADCFDLDEFLNRMLSVGGGFSIDDDVDNEQTGSGIDWDSIGDIALKHTRRVPVGDFMLGVIPAEEKKKQKRTVQRINKNNEEKTAPTEIREEDIQRAENETTTNVKNISNLLEKVGGDTGINLFKFFINPTNFAQSVENLFYVSFLIRDGHASISQDEETKEVILLACMAPTQEDYKEGLSKEQSVFEFDMETWNLAKEMYDITTSIIPTREYQTDTIKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y540</accession>
    <name>I4Y540_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_34288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960866.1">
        <property type="nucleotide sequence ID" value="XM_006960804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y540"/>
    <dbReference type="STRING" id="671144.I4Y540"/>
    <dbReference type="GeneID" id="18471851"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34288"/>
    <dbReference type="eggNOG" id="KOG0427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_15_1_1"/>
    <dbReference type="InParanoid" id="I4Y540"/>
    <dbReference type="OMA" id="HPICASI"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="17416" checksum="B26DDB210078912B" modified="2012-09-05" version="1">MSQLSTKRLTKELKDLKDKGCPAGITLLESDDLRKWTFELEAYDSIYQGEKFALMFRFSDQYPIDSPAVQFIVNNTKGYLSPVHPHIYSNGHICASILSDGWSPVLNVAAVCLTIQSMLTSCKSKERPPDNDGYVARAPENPKKTRWEFHDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y573</accession>
    <name>I4Y573_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_70861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668259">
        <property type="protein sequence ID" value="EIM19115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960842.1">
        <property type="nucleotide sequence ID" value="XM_006960780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y573"/>
    <dbReference type="FunCoup" id="I4Y573">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y573"/>
    <dbReference type="GeneID" id="18475804"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70861"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017716_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y573"/>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="4">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="57799" checksum="C302BC50C91CE924" modified="2012-09-05" version="1">MDNHHGDIKKLPQRIEILTSKGELSDVRGTIKYSGLVDGAEGDWFGIEWDDISRGKHSGEKEGKQYFETIFPNSATFVRPSKKIYTGQSFLKAFRSRYGYSDSALEFAPNIDRITKKLSQTDQLKIASVDHMGVYGVDDLEKENTKQEAKSIRQLSVAHSLISDMEDVDKLVACLPNLQDLDLSSNRIRITNDDYSHICQLKSMKLNNTLIKYQQITQMHHSLSSLEELELAYNNITSLPASYTLGNLQILSLAHNNINEWNEIEGILINLPNLQTLKLNHNKIGRISYPTSNTANSRLKTLILSHNGIDNWKSIDALSLRFTQLESLSLTDCPLMSTQCDVGILRQSVIARFEKLETLNLSEVSIDERKDAEYFYIRNPPTEEDPKRARYHSLCQKYDYQPSVQPAKKLTHLQLKKLSIDIRMDSKTYPLTTISSITIKKLRLIIKRLFDLPSSDFKLIASMIPPPNMFGVVDEERTEVVLDDDYKDLRWFSVENGDHIVVHSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F7</accession>
    <name>I4Y5F7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_41687</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960771.1">
        <property type="nucleotide sequence ID" value="XM_006960709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F7"/>
    <dbReference type="FunCoup" id="I4Y5F7">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5F7"/>
    <dbReference type="GeneID" id="18472225"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41687"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5F7"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM19199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="401" mass="44404" checksum="8252A6FB16E3C7AF" modified="2012-09-05" version="1">MTAATTEVKPAGGIQNYYTSKIEEAELAIHARTQNLRRLEAQRNALNTKVRLLREELQLLQEPGSYVGEVVKVMGKTKVLVKVQPEGKFIVDFAQDIKIDDLKPSLRVALRSDSYTLHKILPNKVDPLVSLMMVEKVPDSTYENVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCAFIRVSGSELVQKYIGEGSRMVRELFVMARDHAPSIIFMDEIDSIGSSRGESGSGGGDSEVQRTMLELLNQLDGFESSKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPGPEARISILKIHSRKMSLQRGIDFKSLAEKMGNCSGAEVKGICTEAGMYALRERRQHVSNEDFELAVSKVLKRAAETNTSSNKLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R6</accession>
    <name>I4Y5R6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_34174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960700.1">
        <property type="nucleotide sequence ID" value="XM_006960638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R6"/>
    <dbReference type="GeneID" id="18471832"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34174"/>
    <dbReference type="HOGENOM" id="CLU_2428748_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5R6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="91" mass="10201" checksum="DBC7638EC0CF5EE9" modified="2012-09-05" version="1">MTGRFPPDTAFFDQGSDVTCTCRLDLLTNIRQLNTPERFGTLSSESNSSLEGTMQLNLGHKNGTINWIETEAYYSPHYNSTILSVRIQIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5S3</accession>
    <name>I4Y5S3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EEF1-gamma domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960591.1">
        <property type="nucleotide sequence ID" value="XM_006960529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5S3"/>
    <dbReference type="FunCoup" id="I4Y5S3">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5S3"/>
    <dbReference type="GeneID" id="18474570"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61503"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y5S3"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="257"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="421" mass="47016" checksum="A1DCBD0622D1024B" modified="2012-09-05" version="1">MSVGTLYTYPNNHRAIRALAVAAANGLTVDVAKDFQMGVTNKTEEFTASFPAQQVPAFKSADGKLALSQGAAIAYYLASLDDKAGLLGKSPEDAALIQQWVSFTETDLFPGVSLPVYMNLGYIQFNKAVADASIQRAEKALKTLETVLKTRTFLVGERITLADITVASVLLFAFQQVLDKKHRETFPASVRFFETVANNYVLKSTFGDYNYIDTFKLNPPKKDEKKTEKKQEKKADKPKEAPAAEAAAAPAPAPEKPKNPLDLLPKSAFNLEEFKRAYSNLDTRGDDPAKHSLAYFYKNFVPEDYSIVQFAFKYPEDLSMVFMSNNQIGGFFTRMEASRKYVMGSGVVLQNAETQKSEIRGIFIVRGKDYLPVLQVAPDWESYSYDLCDLSKPEDKEFFEGILGWDYEHDGYTVQDGKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y1</accession>
    <name>I4Y5Y1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_49025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960523.1">
        <property type="nucleotide sequence ID" value="XM_006960461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y1"/>
    <dbReference type="FunCoup" id="I4Y5Y1">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Y1"/>
    <dbReference type="GeneID" id="18472479"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49025"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_9_1_1"/>
    <dbReference type="InParanoid" id="I4Y5Y1"/>
    <dbReference type="OMA" id="QEPIMAY"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="610" mass="68580" checksum="DCF3DA305FF24064" modified="2012-09-05" version="1">MPSTASKERKQLSSSQSDFFKQTTLPLVEDVLLKSQNALLFAYGVTNSGKTYSMQGGQGEGQEGIIPRTLDVIFNSIGELKANHDFRPSKVSAVESTRQSPHGSILSGLSGHRNQHAQFFHDVFPGKPSSVSQSEDMSFDLDKNYKYAIWISFAEIYNEKVYDLLESLPSTSNLQPSNSVGSMGTAASKKTTIVVKRKALGLRSDRDADAKYIEGLREVRCDSPEQARALLELGTHNRQVFSTLANRASSRSHSIFNIRVMRVHGAAQRDPNAVSFSRLSLVDLAGSERSKNTGNTGERLREAGNINKSLMVLGQCMETLRTNQRRQESKKPVPVPFRHSKLTEIFQSFFVGDGKAVMLVHCNPFDTSFMETSHVMKFSAVARDVTVSKAPSSMLPKKVNTTIKDTLGAIRERIGHTHHSQPKAIKGSDESLSEKFVNVEVGDQSIAMEDEPDTDSNLTDDDEEGSELDSDDENDPFTEFLFSELQEMKERWLEAEMRCAEIEMETREECLELMREQLTLQEVEFADRLRAESEQSEINTNRKIELVNQLHTASQRRRDQARFDVLGEEEDETLNKSMIDKENINDSLLNTPTINRDGKNTNYDAHQLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y636</accession>
    <name>I4Y636_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960578.1">
        <property type="nucleotide sequence ID" value="XM_006960516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y636"/>
    <dbReference type="STRING" id="671144.I4Y636"/>
    <dbReference type="GeneID" id="18474564"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61495"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063755_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y636"/>
    <dbReference type="OMA" id="MSIWLEY"/>
    <dbReference type="OrthoDB" id="10637568at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="28347" checksum="CBBBFD40D61DCF73" modified="2012-09-05" version="1">MRKRQENSDTSSSSPSSSSSSSSSSSNTSSPTSTSSNSSSNTSSSSSSTSNSSSSPSSSSSSNTPSDSSTSSSSESSSASDRPTTSIVTVTLSNGSSTTSATTIPANDGSSGGGKNIGAIVGGSVGGGVGAILILLLALFFIRRSLKKKKLNNNYDGDIFDPQRFRPENGENFEIDNAPTPYVQHPATSSMAGSSAGGMAGVGAAGAMASIPASSTQPPSAHSGSTNQPIGTANGANNVKRPLQPSQTSAVNVHADAGRYAVQNEDPDNLRSDIPPTYDSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y645</accession>
    <name>I4Y645_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960469.1">
        <property type="nucleotide sequence ID" value="XM_006960407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y645"/>
    <dbReference type="STRING" id="671144.I4Y645"/>
    <dbReference type="GeneID" id="18474535"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61444"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024813_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y645"/>
    <dbReference type="OMA" id="GLPSQWL"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="199"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57812" checksum="34AE1F82E876566D" modified="2012-09-05" version="1">MSLLNQLDNLNLNNDNLLQNNNNWLNTLNNQNTFINGEEIIPNAVVIKNIPFSLPKDQLLNIIHDLNIPTPYAFNYHYDTSNPTSDPAFRGLAFANFRTSHDASAIVAALNGFDVLGRKLRVEYKKVLHPEDKERIEREKALRRMASLGINNNNTSTASPFQSSDNFTDSPNLYDSVLSDRDSQASPPTMRHAELDLNDPSTLEIYSRILVFKEDRMRDDLAFSKNLTISQRRIVHLVAQRLSVYHYSIGQAEERFVVVSRNPPNDGSNPSRNDPIRTLKHSSSTIGRSGRPDLVSNTSFLSPASTGIGMQIPPGLRTKKSMPDMKRLNTTTNSFNTAPGLTTRASNSNLKEAYSTVRSTTDLQHFAPPMLSGRRSATLGPGPPGTGGFASLFSPSPSSVNSPRTFSEAGSFHPSTLPFPLDLSATRNGSATPSEQSLTTSPAQLNAQLTSPPIRQPRGPQTAASQGFSQPSSRGISSPALSPQPSPRLNQQLPIASHLKNPNGISSAAPNSQTFTERTSEIMHFNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y667</accession>
    <name>I4Y667_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_48978</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960491.1">
        <property type="nucleotide sequence ID" value="XM_006960429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y667"/>
    <dbReference type="FunCoup" id="I4Y667">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y667"/>
    <dbReference type="GeneID" id="18472476"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48978"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y667"/>
    <dbReference type="OMA" id="GEACQLM"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="489" mass="55842" checksum="09CA28C852ED07D0" modified="2012-09-05" version="1">MSATDLVKLALTHPLEFRTLLQYKIWYEPKRDITSPEEHATTGFDRESMRTCWDFLDKTSRSFAPVIKELDSVLARVICIFYLVLRGLDTVEDDMTIPLDVKEPILRSFHQKLYEPGWNFTESGPEEKDRHLLVKFHAVIDEFLLLDDECKKVIADITKKMGNGMADYCAAAERGQSGVEDIKDFDLYCHFVAGLVGEGLSGLFAATKLEKPFIADQLELSNSMGLFLQKTNILRDYREDVDLGREFWPMSLVKQQGFNSRADLKEPGNEEKALWVISSMVLDALRHAPDVLDYLALLKNQSVFNFAAIPQVHAIATLEACFMNPDILHKNVKIRKAAAVKILMTIRNPRDVAEKFVFYSRKIHEKLSPADPNFIKLSVALSRIEQWTERRFPSLLQFVAGHIDIKKSDKRYITFAEQEKLVSERNDAEKAARIAKDGSFDPDSTASADQVPWSFFFLIIGVCMSIFFISGALVWFFVMWLSDLGNRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6E9</accession>
    <name>I4Y6E9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_22283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960464.1">
        <property type="nucleotide sequence ID" value="XM_006960402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6E9"/>
    <dbReference type="STRING" id="671144.I4Y6E9"/>
    <dbReference type="GeneID" id="18470917"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22283"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="InParanoid" id="I4Y6E9"/>
    <dbReference type="OMA" id="VMDLYPC"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="535" mass="59926" checksum="2EA412E311207D77" modified="2012-09-05" version="1">MTQEGFVVDWLFKNAVERGDKIAHECYADLDSQPILLTWYEFNKRSNQLARWLVDRGVKLEDRVSLSLPRCPEFYIAMAAIFKAGGCYTSIDPELPEERKKYIAKDSESKVIFTTSENITIFTEAAVDSHDTDLWKQVDAQDSSDINLAKLDSLSYLLYTSGTTGNPKGCLIEHRALYWAMVTFGDYPIPISDPESDKRLAMASLAFDVHISEITQSWHEKLRLVTVPRAQLLGDLREYIVKLHITHLGMVPSMIEALLETPEGLPLKYLISGGEKITQNLLEKWANRPNLILANFYGPTELTIGISARKVLAQDTKENVGKVFPSCDALVVDKEMNIVPLGTPGELVVEGPLVARGYLNLDHLTAKSFVKFPNADSWAYKTGDLVRMTPDNSIEIMGRIDSQVKYRGVRLETEGVSNILRLAANEDEELLATTLITQHPSLNQEVLVSFVAPSNSNISVIERRTTSPTIQYNRGTLITSLKNAVDRELPVYMRPAYIIPTNFIPLTLNGKSDNKVLAQVFKLTPMQSLLKSQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6F3</accession>
    <name>I4Y6F3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_55559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960468.1">
        <property type="nucleotide sequence ID" value="XM_006960406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6F3"/>
    <dbReference type="GeneID" id="18472735"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55559"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y6F3"/>
    <dbReference type="OMA" id="QWHNPSM"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="633" mass="69295" checksum="1424B363353F99CB" modified="2012-09-05" version="1" fragment="single">MKPPAYEDVEDRRDPPALDVNAKDKFGTQAGTMKAIAAKQVSNKGVLVALILFIGLASFMMNVDQYTNVTLLTDAYANISNAQAQYQIAAATAILLAVGKPFFGKMSNVIGRPEALLVTLFFIVLGYVVTSASGYHVSGIAAGQVFWQTGFSGFQIILNIIVADNTNLRWRGLWSAMINVWTFILFACSSLIITSVNTGVGWRLAFGLEAILYLPATLPAIVILFLNQYRAKRAGIINYGDQPLTSGPWKSRIYHFIVEHDIVGLYLLIAVLCYIFLPIVLAGSSALVEWNSAYVPASMVVGGVVIFPAFIYWEMKCASYPVIPYYFIKNVNIAITCLINLFDFICFYLSYQTLSNYMAVSVDWYTVVIDGQPTLSGDSSYFSYTQNISLTFFGILWGIVASILKPNWKWSVVVALCVRLLGVGLMLYARDNRNIGALVMTQILQGAGGGIAAVATQVGAQGSVPQQQMALATAAILLFAEIGNVIGQSASSAINMAFLPKKIAEQFPEWSAIQVNTYVNSPMNAVLLGEVGTDERDRMIQAFSNNQRQLIIPAIVIGCVPIVLSFFLKNFKLDERQDAVEDIDENGHDVIAYDASHRHESSAKDSKSAEKASTHPEEPVHKATSEEIGQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I9</accession>
    <name>I4Y6I9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_48842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960379.1">
        <property type="nucleotide sequence ID" value="XM_006960317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I9"/>
    <dbReference type="FunCoup" id="I4Y6I9">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6I9"/>
    <dbReference type="GeneID" id="18472471"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48842"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6I9"/>
    <dbReference type="OMA" id="TQEMKPR"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="29186" checksum="FA4BA95EAB5EF404" modified="2012-09-05" version="1">MASIVVTKIATGTTDEQIVKFFSFCGKVKSSSFEQDTTHRTAYIEFERESAARTALLLNGGNLEGSLIEVSSKEVSNTSPAASPAATTDKASQAAAMEVDTINDNVAQEDKPRTAILAQYLAHGYHIGDEAIQKAIDLDTKHGISSKFITYIKQLDTGVGKKTGEQPLSSQLYEKAQGLFGKAKEIDNQKGISEKSTSWFGPYYQKALASPYAAKVQNFYTNASKQVLDVHEEALRIAAQKKETFVRDGGDTNATTIAKAPADTDEKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K5</accession>
    <name>I4Y6K5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_22107</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960395.1">
        <property type="nucleotide sequence ID" value="XM_006960333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K5"/>
    <dbReference type="FunCoup" id="I4Y6K5">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6K5"/>
    <dbReference type="GeneID" id="18470911"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22107"/>
    <dbReference type="eggNOG" id="KOG0450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6K5"/>
    <dbReference type="OMA" id="IRIRRHN"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="630"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112849" checksum="D0620EE49840D1A0" modified="2012-09-05" version="1">MLRRSLFNSRLCSRRLLSTSIRVSQDTLKQPPAPFDAFSTTGLDHAFLESAYGEWRKDNNSVHPSFATYFEALENGVDPAEAFVPPPKLAGALADSAASPKHTDLGDHLKAQLLVRAYQVRGHHLASLDPLNLTQTDVNNMVPPELKIDSYGWSERDLDRQISLGPGILPRFAIDGRNKMSLREIIQTCEQIYCGPIGIQYIHIPDKDQCDWLRKRVEIPHPWRYNIEEKSNILDRLLWSTCWEQFIAAKFPNEKRFGLEGAESLIPGMKALIDRAVDHGTKHITIGMPHRGRLNVLSNVIRKPSEAIFNEFTGANDDTQSGGGDVKYHLGANYTRPTPSGKKVNLSLVANPSHLEAENPIVLGKTRALQHIEGDEGKGDSSLGLLLHGDGAFAAQGIVYETLGMVNLPNYGTGGTIHVVVNNQVAFTTDPEDSRSTAYPTDIAKSIDAPIFHCNGDNAEAVTFVFQLAADFRAKFKKDVVINLVCYRKHGHNESDQPSFTQPIMYEAIAKQPTALAKYVKQLQQEEAFTETQMEEHRKAVWSKLESAFKNAPNYKPHGREWLSSSWEGFPSPDDLAARVLPTATTGVKQETLENIGKVISTFPDGFTPHKNLARIIGNRGKMVMEGKGIDWSTAEALAFGSLALEKIHVRLSGQDVERGTFSQRHAILVDQQNESLYMPLNHLGSRQAGVVVCNSSLSEFGTLGYELGYSLVSPDNLTLWEAQFGDFANNAQCIIDQFIASGERKWLQRSGLVMSLPHGYDGQGPEHSSGRIERFLQLADDNPFSVPTEEEMARQHQDCNIQVVYPTTPANYFHVLRRQVHRDFRKPLILFFSKALLRHPMARSTLEEMTGETQFERYIPENSEKMVEPEKVRKHILCSGQVYHTLYKEREERQAYDVAISRLEQISPFPYDLIQSHLDKYPNAEITWCQEEPLNNGAWSYVSQRLLTLVKQTKHHSERWPQYVGRDPSSSVATGSKAVHTTEIKKILDAAFSSEPGNVRFAASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6V3</accession>
    <name>I4Y6V3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960203.1">
        <property type="nucleotide sequence ID" value="XM_006960141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6V3"/>
    <dbReference type="FunCoup" id="I4Y6V3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6V3"/>
    <dbReference type="GeneID" id="18471756"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33837"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="InParanoid" id="I4Y6V3"/>
    <dbReference type="OMA" id="IYVREQI"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="145"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="40238" checksum="E582A4669E22CB0E" modified="2012-09-05" version="1">MSQITLNFGLVGLGGITETFAKDILADPKERGVSDVKHNLVAVGSSSAKKADEFLQRVGAPSSAKGYGSYEGVYTDSNVQIVYIGTPHSHHYHNAKDALSNGKHVIVEKPAVISAPQMRALVDLAHSKRLFLMEAKWTRFFPMLQEISQKLHSGVIGDIKLVQADFGQTFVGLSPEHRIFNINLGGGSIMDLMPYPLIWVFSVLYYHPDNKLVKPEVRGASCIKNKYGVDENTHALLKFPGINADAVCTTNINIGSVSTLTVRGEKGELIIHDLPLSRPQSYEIRLRDVNHPSPDNQARKVEKFNFPIPNHGMHWEADECARLIHRGELQSSVVPWSDSLLSAEILDDIRKKAGINFPESIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6W4</accession>
    <name>I4Y6W4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_48611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="551"/>
            <end position="695"/>
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            <begin position="716"/>
            <end position="762"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="309"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="603"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="635"/>
            <end position="764"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="305"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="523"/>
            <end position="547"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="570"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="596"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="655"/>
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            <begin position="712"/>
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            <begin position="751"/>
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            <dbReference type="ARBA" id="ARBA00005783"/>
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            <dbReference type="EMBL" id="EIM19706.1"/>
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            <dbReference type="Proteomes" id="UP000005242"/>
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    </evidence>
    <sequence length="764" mass="85801" checksum="C36D13E64A196239" modified="2012-09-05" version="1">MPKSKSNRGALLLDNLPQLQGLIKRDPDGYKDEFIQQYNHYQSQMKIFQLQPNSDLDKFSDLVGFIAQVASCYPKETAEFPAQLSSLIIEYHNHLTPDTRKTLVQSLVLLRNRQVIPSIDLLKVLFQLLPITTSATLRSYIRNVILTDIKLANQRSKNHKLNRVVQALLFSMVERGMDAEVQSTKSKAKKSQDSSFATKAGAEAMWAVMLTRELWKKGVWNDAKTVSIVALACFHPTAKVQNAAVHFFLGSDDAIEESEDEGEDIDMKKVQHQALINKSRKSVDKKVAKQKKAAKKQQANKDNASTPNFPALQLLNDPQGFSEKLFESLTKTDKVHSLDHRVLVMQLLTRVMGAHKLCVLSFYSYVIKYLTHHQLRITLILVAIAQSVHELTPPDVLTPVIRKLAHEFVTPGVGSEVVAAGLNAITEICRRQPWAMESDLLEDLIEYRKSADKGVLTASRGLLQLFREVNPGMLKRKERGKLASMGLSSGKEVLKYGQSGEAASGIEGLDLLEKHLADKDNEGEGDEEDEEKAWDDWDVESGDESSESEGWVNVSDDDDDEINLSDSDDEDSKKKKKEKKDSEEQAEKATDEPREESTDDAIQRLSTLATERILTPADFALLNDLKMKAVQDEIDQGGGAAAKRKMAQLKEKRKAQGSGADGDDEGQFVTEAEIIGPRKRAKNDYEARMESINQGREGREKFSSRKGKHKSEKIASKTNEEKKRNKPMMMAIHSKKVKSKSQSKLIDKQKALHKHKEKQRKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y704</accession>
    <name>I4Y704_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_61352</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960254.1">
        <property type="nucleotide sequence ID" value="XM_006960192.1"/>
    </dbReference>
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        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y704"/>
    <dbReference type="GeneID" id="18474478"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61352"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y704"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="382"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="542" mass="61539" checksum="5D3F0B8EF1A9CD22" modified="2012-09-05" version="1">MLLVSQAIVSELVQAQEKGQSVSLNDIRIKQCKKHKISGVPKLVDIIAAIPDEHKKTLLPMLKARPIRSASGIAVVALMCKPHRCPHIAMTGNVCVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQSRGRVEQLKMLGHSVDKVEYIIMGGTFMSMPEDYRNKFVAQMHNALSGYTGTDIDEAVLYSERANTKCVGITIETRPDYCLKPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVRAVSESFHLAKDAGYKVVAHMMPDLPNVGVERDLEQFKEYFENPAFRSDGLKIYPTLVIRGTGLYELWRTGKYKNYTPNALVDIVARILALVPPWTRVYRVQRDIPMPLVSSGVENGNLREMALARMKDFGTECRDVRYREVGIHEIHHKVRPSEVELIRRDYTANGGWETFLSYEDPEKDILVGLLRLRKCSEEGTFRKELIDTNEETGETRYASMVRELHVYGTAIPVHGRDPTKFQHQGFGTLLMEEAARIAKEEHGSHRLAVISGVGTRDYYRRLGYKLDGVYMVKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y777</accession>
    <name>I4Y777_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Gpx1</name>
        <name evidence="8" type="ORF">WALSEDRAFT_33813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960153.1">
        <property type="nucleotide sequence ID" value="XM_006960091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y777"/>
    <dbReference type="FunCoup" id="I4Y777">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y777"/>
    <dbReference type="GeneID" id="18471753"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33813"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y777"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="18149" checksum="C8D8555C151DABC7" modified="2012-09-05" version="1">MSASEFYNLKAEKPNGQEYSFDTLKDKVVLVVNTASKCGFTPQYTGLEELHQKYKDRGLVVLGFPCNQFGGQEPGTDDDIDNFCKINHGVSFQLFKKSDVNGDKTNEVFKYLKDKKSQLGLTRIKWNFEKFLVDKQGNVVNRYSSMAKPSDIGNDVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7N0</accession>
    <name>I4Y7N0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TTL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959903.1">
        <property type="nucleotide sequence ID" value="XM_006959841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7N0"/>
    <dbReference type="FunCoup" id="I4Y7N0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7N0"/>
    <dbReference type="GeneID" id="18475050"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65763"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397003_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7N0"/>
    <dbReference type="OMA" id="NPDEDQS"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="498"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="694" mass="76838" checksum="18197FCF270F463E" modified="2012-09-05" version="1">MTAFVNFPSSYTQSTVERAFRKYLPEVSITTDKPSDRVQIQYADYDLIEFDWLMQDSDNSIGSSYCFRKALTRKNYLHQTIEAYLAKIEHRLSVNAVDASEKANVELLRKAMPKCWTIDVAHSEDLDEVLMDELYDLNQAMNDESDSWFILKPAMADRANGIRLFNSEETLREIFEEFDSDSEDEDEDEGEEDEESTAVSTSQLRHFVIQEYISNPLLIDPTGGKDTFNKFHLRVYVLCVGSIKVYMPTSILALFASQTYKQPDEDQSLLSHLTNSCLQGSNMDRNTFVKSLEELEGCYTATGEQITPQQIEGWLDSASKVIGQAVKGAVESGSVHFQPIPNAFEIYGVDLLVTETNEVKLLEFNGCPDFGQTGDRLAWIVDNVVDASFEKGILELLGKNNISNTVKTIKCLDYEFKRAEDGEAPRAPAPAQAPAQAQAPAAQQQKPRTQQKPRTQQKGAKDSAKDESLPSERAPRGERGAKRSRGAKTPGNPGGQRKGRQFDRQSQTGRTDSNKQKAAWGGEDGQKELATEEAAKKDAEAAETAPGTPAEPKEPEETTKTLDEYLAERASKKLDIGAPEVRKANEGTEGVSGVQLLRDSQEEHYFVAPKAQPKEPKAKSQKSSKVTIEIDGQFAKPESERRPRNTNGRGPSRGRGRGGAAGRGRSGRQGGPQRKENAGANVNLNDEKAFPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7S9</accession>
    <name>I4Y7S9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959951.1">
        <property type="nucleotide sequence ID" value="XM_006959889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7S9"/>
    <dbReference type="GeneID" id="18474381"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61188"/>
    <dbReference type="HOGENOM" id="CLU_409509_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7S9"/>
    <dbReference type="OMA" id="STVECKE"/>
    <dbReference type="OrthoDB" id="10609623at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="671" mass="74122" checksum="CF36F28325875899" modified="2012-09-05" version="1">MDNAPAGSKAAREAHQEQRIRQRGGEIHKSAPLKLNIPKPAIQEPAVSPFAAPPDVNPAFNSLFSQLSATKGSPVFRDSESPATGSPSLGRVSRLSGARKDSSVSLSSRAPDSQPSRRDEQLEHDLFPSEASQSLRKSTAKNTPSSRRSESIRHPDSSHSRRDDSGSIEGRAGSAQSQSSNEQTRLSLQNQIQFGRNVSLEKSTRDSSSVERAQRSSLEKPLPPLPSHEDDFDTIPESAQKMNRLKKKATKSLDRSHKRPRVSAPKVAPPPTPPEELDELALRPKEPAREVPKVRRIKTSEPRPPKPRDIFKRPILPLSRKRQGEQLGQTAKEPSDRKKVPDEIFEYKALIAPPNDGVDELIDEIDAKHKHVAGRAINRSLTIVNELDVVWEIVTDEIEEAIARAQSRTMMHDLRHMMSILEVGFVKKVQSYYHVIGLLARLSAAKTQQKELRAQLLATQTSRSEIAKNMAQKEKEWHSTKKARREMAHLNIWLHDLEESKMEVSGEDDGSVDRIPTKLGDDYMSILSALRLIEPMHTDGGTDRTMEEVNMLYELCEKEGVFDDVEEEDDEEDMESVSSVHTSDIDSSELESLGGDSDGLSDDDRPASSSTRGISSNSQDASIKSHGISLGTGDVSPSTRQDSMSTGDISPSNRDISPSSSVSLSKGDRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y839</accession>
    <name>I4Y839_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_40390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959852.1">
        <property type="nucleotide sequence ID" value="XM_006959790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y839"/>
    <dbReference type="FunCoup" id="I4Y839">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y839"/>
    <dbReference type="GeneID" id="18472170"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40390"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y839"/>
    <dbReference type="OMA" id="RMQQSVR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="163" mass="18210" checksum="235530E1775F1A2A" modified="2012-09-05" version="1">MDLQKLQRMQNASRAGGKNAPRRKQVRKPRSEADDQKIQAALKKINVQHVQGIDEVNMFKEDGNVIHFPKPIVHSAAPANTTAIYGRAQEKELTELVPGILPQLGADSLANLRRLAEQYQQMTQQQQQAALNKAKEQDNGDDDVPDLVENFEDSTNAESKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8A1</accession>
    <name>I4Y8A1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959681.1">
        <property type="nucleotide sequence ID" value="XM_006959619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8A1"/>
    <dbReference type="FunCoup" id="I4Y8A1">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8A1"/>
    <dbReference type="GeneID" id="18474306"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61047"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y8A1"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="39"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="346" mass="37843" checksum="6CCF097783192EDF" modified="2012-09-05" version="1">MHNSKDYIAIGLEGSANKLGAGIVRHNRDGSVDVLSNPRHTYITPPGSGFLPADTARHHKHWLSRIIQKALHDAELTINDIDVIAFTKGPGMGAPLTAVAMVARTLSLLYNKPLIGVNHCIGHIEMGRLITGAQNPIVLYVSGGNTQVIAYSQQRYRIFGETLDIAVGNCLDRFARVIGLPNDPSPGYNIEQAAKSGSQLLKLPYTTKGMDISLSGLLTATSSYTKKPEFGTEFTKEDLCFTLQEVAFAMLVETTERAMAHVGSKEVLIVGGVGCNKRLQEMMSTMAAERGGKVFATDMRFCIDNGLMIAQAGLLQYRMGQTTELKDTVCKQRFRTDQVHVSWRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U3</accession>
    <name>I4Y8U3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate synthase</fullName>
                <shortName evidence="23">DHQS</shortName>
                <ecNumber evidence="23">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="23">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="23">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="23">EPSP synthase</shortName>
                <shortName evidence="23">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate kinase</fullName>
                <shortName evidence="23">SK</shortName>
                <ecNumber evidence="23">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="23">3-dehydroquinase</shortName>
                <ecNumber evidence="23">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="23">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="32" type="ORF">WALSEDRAFT_61030</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22 23 24">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 23 24">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23 24">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23 24">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23 24">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="24">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="23"/>
    <dbReference type="EC" id="2.5.1.19" evidence="23"/>
    <dbReference type="EC" id="2.7.1.71" evidence="23"/>
    <dbReference type="EC" id="4.2.1.10" evidence="23"/>
    <dbReference type="EC" id="1.1.1.25" evidence="23"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959641.1">
        <property type="nucleotide sequence ID" value="XM_006959579.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y8U3">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8U3"/>
    <dbReference type="GeneID" id="18474296"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61030"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8U3"/>
    <dbReference type="OMA" id="SWANMSW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="EIM20385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1530" mass="165371" checksum="6A084AFFFD29310C" modified="2012-09-05" version="1">MFSHRLTRDTVVIALGGGVVGDLTGFLAATYMRGVPFVQIPTTLLAMVDSSVGGKTAIDVPAGKNLVGAFWQPKFIFIDVAMLETLPQREVSNGMAEVIKTAAIWNAEEFTDLENNAAAILSAVSKPSSTAQQKHVGRHISNRSAEQSLILKVISGSIGVKAHVVTVDERETGLRNLVNFGHSIGHAIEAIVAPEVLHGECVSVGMVLEAEVSRALGHLSQVAVGRISRCLKAYNLPTSTSEALFTRLPKSANITVDRLIEIMAVDKKNAGSNKKIVLLGSVGSTVEQKASIVKDDLIRRVLSSAVRVEAGKPPNHFTLSTPGSKSISNRVMVLAALGKGTVKIRNLLHSDDTKVMMSALNDLQGAKFAFEDGGDTLVITGGEGKLSPPDDGKQVYLQNAGTAARFLTTVCTLVKPSSKQQSTIITGNARMKQRPIGPLVDALRSNGSQIEYLESEGALPLHIASKDSGLAGGHIRLAASVSSQYVSSILLCAPYASEAITLELVGGQVISQPYIDMTIAMMKDFGVNVERVKDESGKLLDMYKIPKTSYTNPAEYNVESDASSATYPAAIAALTGTTVTIKNIGSESLQGDAGFAKNVLEPMGCKVIQDKSETTVTGPTDQPLRALGDIDMETMTDAFLTACCVLAVATGEPLSGKKRTGNGTRIYGIANQRQKECERIQAMADELAKFGIKTEQDPDSITVFPRPADELNTEVVVHCYDDHRVALAFSCLAQRVAGTVLDEKRCVEKTWPNWWDDLQNKIGIPVSGVDAHPVAGPPSPKLAPVPAAAPSGAYIPDASIFIVGMRGSGKTTVGKLAAGTLGRNFLDADALLEEETKVTVYNYVQQFGWEEFRKAELKVLKKLIEKHAQGYIISLGGGVVETEEARELLKAYANDKEGGPVVYVERSEDEIVNYLQLEKDRPAYATGDEVKDVIKRRKPWFSECATHRFINHLNLQAQVNELLSGKQVDLSSKLLRSEVREIKRFFNFISGEDLNQIDVDARRTYFLSLTYPDILEALPIMDQLSAGIDALEVRVDLLSEDGKAPTVPSVPSADYVSAQLSALRQCTSLPIIYTVRTHSQGGMIPDEKFEDIAALIELGIALGSEFIDVELNLPDSLIDDVVKRKGNSKIIASMHDFPGNYKWDSTEMSQKYSQGAKYGDVVKLVGRANSLEDNFETSKFLSKLPASPPVLAFNVGVIGQLSRIQNYVLTPVTHELLPSKAAPGQLSFKEIQQALNLTGQLDSKKFYLFGCPIQQSQSPTLHNTGFQQLGLPYVYSLHEREQLDGSVDQILESPDFGGASVTIPHKVGILNKIHTLSMPAKAIGAVNTIVVREDVNGKRELFGDNTDWQAIKSCAQSSVDGSDPITKESAGLVIGAGGTCRAALYALHALGCGTIYLYNRTKENAENVTKDFPTFNIQVLDNLNNVVEKPQIIVSCIPASATTIEEGSGDGIYLPKTIFGRQSGVVIDMSYKPLKTPLLRLSEEANGWVGVPGATILLEQGFAQFKLWTGRQPGRKGVEKAVWQRYLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y907</accession>
    <name>I4Y907_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959475.1">
        <property type="nucleotide sequence ID" value="XM_006959413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y907"/>
    <dbReference type="STRING" id="671144.I4Y907"/>
    <dbReference type="GeneID" id="18475012"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65355"/>
    <dbReference type="HOGENOM" id="CLU_676531_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y907"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46864" checksum="06BA98E9289F0912" modified="2012-09-05" version="1">METWRKLPLELWNYIIELAYQNGDGDWNAARRASQVCRCWRDMLLSIPSIWQNVEMYEHDLNEHDIRLSFALFVKTIRDRSKDRIKNVKVILRETKVPGVAIRTLLDDDKLDKIVVQYTESFNGPFFAPPTCKALEAYSTHTRNDAVIIQNNHFESVRLKNVLPWSVNADDGISNGLKHLSIDLQERSKDKMTAYTISQCKDLETLHLENLNFSLHVPVVLNKLKKLSLVGSETLLKYLEAPSLDVATIYGLRDSSSYLSYLDVRPLRYLRIQVDDISDVTSSAFTNEFENLEVLQIDNNIPVDCPDARDLLKHILLKKATAKLKAIKISSGYHNISPILRAPQNLSKIEEFVVEDADRFTTDASKDLDDIEWLKKNIPKLHHGNYCNYDKKDSYFPITFSFDNVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y946</accession>
    <name>I4Y946_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_39915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959514.1">
        <property type="nucleotide sequence ID" value="XM_006959452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y946"/>
    <dbReference type="FunCoup" id="I4Y946">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y946"/>
    <dbReference type="GeneID" id="18472142"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39915"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="InParanoid" id="I4Y946"/>
    <dbReference type="OMA" id="LGPNWYA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43953" checksum="A31F2D833F47417D" modified="2012-09-05" version="1">MSNVIYDLKKGLRKRVVNITPVWFAMTMGTGILSILLFNCPYQFNGLQTISGVVFGINVVLFVVLLLMTIARYAIWPSMLPLMLVNPVNVFLATLTMGFSTIIVCIVDFLVPRYGYNFALLSYVFWYINVAMSIITCIGIPFIQMSRQTLENSQIFATALLPTVSTIVCASTGAAVATVLPENQAIVTITICYILLGMGVPMSLIVLANYTSRLMLFKIPPAAVISSTFIPIGPCGQSAYAILKLARNLTDIANERGLVPFTSVEDPELAKFAASALQTASIPFALIIWGFGCLWLALAIISFFDTMISKRIPINLSLWGCTFPIGTLALSAQELGKEMNVTGMKVVSVILLITLVIIWLILMALTFYNGVIRDKWFSSPCLSDAGGTPPSMHDVEFNRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9F0</accession>
    <name>I4Y9F0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_39706</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959382.1">
        <property type="nucleotide sequence ID" value="XM_006959320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9F0"/>
    <dbReference type="FunCoup" id="I4Y9F0">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9F0"/>
    <dbReference type="GeneID" id="18472123"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39706"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="InParanoid" id="I4Y9F0"/>
    <dbReference type="OMA" id="AVHIKAD"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="171"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="431"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="693"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="760" mass="84708" checksum="552715641BFEACE1" modified="2012-09-05" version="1">MDDDIVINFTSGGSRQDRSKKGGRWTDRASAKQNAKRSQRFNNKKQKSEPSPQQEEQHPVNPPAKKAKSTPTDSQNAIDNQATQNTQNNQKKHVVSSLFTFNPEIEEIKEDKGPKQPQQAPSNAPLASTSSFEGAKLHPLLIQHLRDKLDIKAPTPIQKLALPTLLQPTEKDSVLSSRDVFIQSQTGSGKTLTYLLPIIQDLLPLGELSFIDRSIGTLAIILAPTRELARQIFDVLENLLHLSLTLKGVPEEDQKRLTRWLVGGLLTGGSTRTHEKARLRKGCPILVSTPGRLLDHLQNTTSFNASKCRWLVLDEADRLMDLGFEETITGIIKGLEGRRKLTKKAIDEGSLSEVGGWDFDVRRRNILCSATIREDIQSFASQQLLNPIVLKESDIKKDVDTNAAEESTKFTPPAQLSQKYVQVPLKLRLVSLLALLRSLATSKENVQGNRIIVFFSCTDSVDLHFQLFGGVSMTDAGNRNVDDKLSVTCPVLPNTKIYRLHGSMSLQNRLSTVREFTDKKTTEPAIMFCTSVASRGLDMPLVRAVIQVDLPTEGGANEYVHRVGRTARAGKGGEAWSFVAPSEHGWVDWLTSQLDSDTKSIKLHPVSVENVLKRGYGGQGTEFESRATDVQTSLERWVIASPDNSQLARQAYLSHIRAYATHPIEERKFFHIKLLHLGHLAKAFALRETPTTASTTKADIAQSKDNQKHQSIEQKMQESVRRIGKSTKRDGEFANNDTSEFQTSLSGYDMKQPKPNKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9P0</accession>
    <name>I4Y9P0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959215.1">
        <property type="nucleotide sequence ID" value="XM_006959153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9P0"/>
    <dbReference type="STRING" id="671144.I4Y9P0"/>
    <dbReference type="GeneID" id="18474170"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60798"/>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171392_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9P0"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="237" mass="27038" checksum="7C1BEB157E12C6F1" modified="2012-09-05" version="1">MNGHINSIPKNNIWLGYTLDYPSDSFSHLEINYVHPLIQPNFDVIASLYSIARHNNIEIRSPALLETYKQSIMGNTTSNYHSTMLNYKIDAITINCIPNNGPHGFLSLGRLLEGYTRSFNNLIERLHASLSFYLFFDNKLIKLSDYIPIIIIASLINIIQAFEKFEISSKDAITITIVGYVTNTFLNPQISIILSTFILRFITNRTSYKLLTTMIMIYTSLYNFYVSLSVALISTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9R7</accession>
    <name>I4Y9R7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_33145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959242.1">
        <property type="nucleotide sequence ID" value="XM_006959180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9R7"/>
    <dbReference type="STRING" id="671144.I4Y9R7"/>
    <dbReference type="GeneID" id="18471626"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33145"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y9R7"/>
    <dbReference type="OMA" id="LTHFRYT"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="344"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="566"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="625" mass="70475" checksum="490678DCA43A511A" modified="2012-09-05" version="1">MFSCIFGRDTENKHTYEKVPIEHLPSFETKLLQTSQTELNDRLEDFRELLTDNKLDYYIVPTTDAHASEYVADADARLAFLSGFTGSSGVAIVGAYDAHLWTDSRYYIQAERELSRAWTLHKDGLPGVPTWTEWLSKYTQSARIGVDPKLMTYKQATSIEDILRDVESQLIYTEHNLIDQIWYERPALPLRPLFVLGMEFTGKHASEKLKDVDNWLGPKRAFIASALDDIAWVLNLRCQDSVPFNPVFYSYLLISQSKKVLFVHKDQLTGVVSDYLSDLNVEIKDYANIDNTLKSVSSNYTTIFASETVSRAVASDSGFSRIRTTTSPITLAKAAKNPVELKGAREAYKRDGLAFVRFLAWLDGQVRAGNPDLTEWNVSAKFDEIRSKLPLFKGLAYENISATGANAALPHYSTSKDNSPKLDLTTPYLNDSGGQYLDGTCDTTRTVHFGKPTKEQKVAFTRVLQGHIAIDSLVFPEGTTGGHIDVLARRPLWLENLDFGHGTGHGIGAYLNVHEGPHGINKGLSFAQFPLRVGCMNSNEPGYYAENKFGMRIESVVTVKESSKKGWLKYERLTKVPIDKRLVDYSLLTQFEKDWLNAHNEDVKQTLLPLLDKSDKLTRKWLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9S8</accession>
    <name>I4Y9S8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MBOAT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959253.1">
        <property type="nucleotide sequence ID" value="XM_006959191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9S8"/>
    <dbReference type="FunCoup" id="I4Y9S8">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9S8"/>
    <dbReference type="GeneID" id="18474181"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60813"/>
    <dbReference type="eggNOG" id="KOG2704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011340_5_2_1"/>
    <dbReference type="InParanoid" id="I4Y9S8"/>
    <dbReference type="OMA" id="WHGTRPG"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="547" mass="62125" checksum="D49C1E6002961C2F" modified="2012-09-05" version="1">MIDDFYSGLSAKVGGIPIDHLKLISCLLLSYPLSHLFLRIPSQYPSLRNAFNLLCSLFFLIGIFDLKYGLLNLLFNSIVSFYLAKSFSAYSWMPWVVMGFAMTHLLLFHIQRLIHVTPSTAIEISGSLMVLIQRTTTYAWNVHDGQLKEEELEDYQKDNRVMKQPPLLGFLAYTLYFPAILVGPAFPYDAYASLVDNSLFETSRPRKLKGRRRAGYRRMVFGLIFMALYAVFGGSTDMGFLIDSEWKKNHGILSRIAFLQKSAVITRCKYYAVWSISEGACIISGLGFNGYNEKNGRTRWDRVRNIDVLGVELAQNVKELLDAWNMNTNVWLRSCVYKRVTTKGKKPGFQSTLITFVTSAFWHGLPMGYYLTFIYGGFLQALGKLVRKNIRPFFIDTSKKPLYDVLSIVTTQMLINFAIIPFMLLGFKNSLKGWYSVGGYGIIVVIVAFNYFKYMGGTDRLQTKLKQRRDDALEELFDGTPTAEMRDKAGLDEELLTRDVDEIMEKLTKHGTLASREAADQIKDLSNEGKTITKGVVKDAVNVSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA17</accession>
    <name>I4YA17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mis18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959073.1">
        <property type="nucleotide sequence ID" value="XM_006959011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA17"/>
    <dbReference type="FunCoup" id="I4YA17">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA17"/>
    <dbReference type="GeneID" id="18474117"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60714"/>
    <dbReference type="eggNOG" id="ENOG502S9R8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1300543_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA17"/>
    <dbReference type="OMA" id="WVISHRE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431:SF1">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="12">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24197" checksum="9793B66B4A2957DB" modified="2012-09-05" version="1">MDISVDPVVFYCSGCHKILGDTLSFIETNDILKSIVLSSVTNSVDISTTINTSNDTLDTGSTFVWLNCSNCQRLIGKKYHSTPDHLAYLSDNFSLNMFNGNVAWYQLGSQKPQSSIRQSFTEQDSDGADLSDLFKIKSVLLHYQQRLDNNDKGQLSLRQKLNEHDKRLDSFDKDQIDLQQDLDDRIQSIDSLQHKLKLLQRRLDHLESKIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA44</accession>
    <name>I4YA44_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF625-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_39318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959098.1">
        <property type="nucleotide sequence ID" value="XM_006959036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA44"/>
    <dbReference type="FunCoup" id="I4YA44">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA44"/>
    <dbReference type="GeneID" id="18472111"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39318"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="InParanoid" id="I4YA44"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="211"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="738"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="874"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="902" mass="103333" checksum="339BD65E8881EFD4" modified="2012-09-05" version="1">MEETEGESNRSTNLDLNEGSNSPDRPPSASLGSPPQNGDQLGESEKHVDEPNEESPREPSSSPPPTDAARRVKIYKLTTQDWVDHGTGFCTGIYDSERDEAMLVVANEDNQDQILLNHFISPADIYSRQQDTLIVWTESDGTDCALSFQEADGCLEMWDFISQVQRHVQKTDDYPYIIDSPVQRRQKQPSQKFNLPPDTPDLGNLEEVYVNIKDCLSRTMQGREKLITWLINNNYIAKLIHVFNQAEDLEALAELHMLSTILHYILSANDSVIFEYVLSDEIFLGMCGILEYDPDYPTLKASYRLDLTTTSRYKEVVPIHDQNLKSKIHQTYRLLYLKDVILARTSDDTTFTLLNSFVYYNQIDIIKHIQNDTDFLDRLFGIFNDPSTDTPDQPPTLRQDAVLFLRDLCTMGKNIQMQTRQELYKALVNRSLLDVCKWSIKRPEPILHSIGSEILMIIIDNEPNVVRHFILTEANSTKEKSKETFTLMQEMCLSLDSSRDLGYKNQISEAIRLLLEPPNAAAEAAWTVAKPRLDPTNDEFLSYFYDTCINSLFKPLLESPDIPLNEGKLMFQFLLISDGNVAPPQLDFNQSTIALSLCDLLSFFVTNHQFRAQYFILQTPISKKLVQLLRVKQKHLRLAALRYLRACVSLNNEFMVRYLDRQDLFKPMLDVALREGRKDNLISASILDLFESIRRINNRVMINSLVGKHEEDVRQLMKYTFIGGVFTKLFERWEQLNEPAQPEASTSTIVDNNSGGFLRERKSSDATAEDDYFNKDDEDEARNYINDDPGGNTTNKTTHHSLSNAPTPTATSLVDYNDEDEEDQKRNSVETRAVVDKDEESTPAEERLTHMEVRLSEKRQREEDDDDQVAQLMHNKKRLSPTNDNDNTMTVINLNNNSNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA96</accession>
    <name>I4YA96_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959147.1">
        <property type="nucleotide sequence ID" value="XM_006959085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA96"/>
    <dbReference type="FunCoup" id="I4YA96">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA96"/>
    <dbReference type="GeneID" id="18474144"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60755"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_2_1_1"/>
    <dbReference type="InParanoid" id="I4YA96"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="65"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="247" mass="28754" checksum="B186797C620D1D39" modified="2012-09-05" version="1">MSTGELKNIKNELYNNKNVKSNLTRAKLLLAQLGLVIPKDSDKNDELADLKDILEYGCHYSIRETDISAFESYLNLLKPIWIHFNTQSPDIISLQLLIQLIQNKISDFHTLLETLPIELLNSHEISIPVKLERFIMEGSYSKLFDYKQHLNQWIWDQLLFTIRNQIALSQETAYQSLPINDAATLLYFKNQSELMEFSKQRGWSVSPSTQHLVFKQYNLDDKQIYTIPSKNMISHSLNYAKELESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC4</accession>
    <name>I4YAC4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Sulfiredoxin</fullName>
            <ecNumber evidence="2 9">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_29138</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2 9"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958914.1">
        <property type="nucleotide sequence ID" value="XM_006958852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC4"/>
    <dbReference type="FunCoup" id="I4YAC4">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAC4"/>
    <dbReference type="GeneID" id="18471080"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29138"/>
    <dbReference type="eggNOG" id="KOG3388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124532_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAC4"/>
    <dbReference type="OMA" id="SQIRRPI"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017267">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="11">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="114" mass="13177" checksum="1857906E7F71640C" modified="2012-09-05" version="1">MTTLPNTSVFQASERSDNVHDEEVPMRVINRPFPPELDEAKVERFMRDYEEGDTFTPIEIWRARNAQGQSFYFSFGGCHRYEAAKRLKRETIRSRIVDVPSTTIRAHLGTSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ4</accession>
    <name>I4YAJ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_46814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958975.1">
        <property type="nucleotide sequence ID" value="XM_006958913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ4"/>
    <dbReference type="STRING" id="671144.I4YAJ4"/>
    <dbReference type="GeneID" id="18472402"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46814"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="I4YAJ4"/>
    <dbReference type="OMA" id="RRMAPIT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="196" mass="21788" checksum="9269D1BAC3B2FC34" modified="2012-09-05" version="1">MASKNIKCVVVGDGAVGKTCLLISYTTNQFPSDYVPTVFDNYQATVLLDGKPVLLGLWDTAGQEDYDRLRPLSYPQTDIFLCCFSIHSPASFENVKYKWWPEISHHAPGVPIILVGTKLDLRSDPQAVNALRARRMEPINYSQGVELSKDINAIKYLECSALTQKGLKGVFDEAIRAVLVPQGRKSKRKQKGCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB05</accession>
    <name>I4YB05_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_38909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958821.1">
        <property type="nucleotide sequence ID" value="XM_006958759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB05"/>
    <dbReference type="FunCoup" id="I4YB05">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB05"/>
    <dbReference type="GeneID" id="18472087"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38909"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_928136_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB05"/>
    <dbReference type="OMA" id="LYWNNFA"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="292" mass="32733" checksum="1A69F338E63AF38D" modified="2012-09-05" version="1">MKEIIENLYLSDILLSGNGHSILKDLNIERIVAAFKGDLPGYSSNIEVYQVAVDDDDEEDILEHIPNVINWIDEGLQQSIPTLVLCQAGVSRSAAIVTAYLMRKKTLSVEDALSYLQSVSPSADPNQNFRHQLKIFELAGYSTSTENPLVRRYKLLRKARTISGYQQDDDGSSLLQLYQQRRSISKSTAIRCKQCRMKLAGYEDIVMYIPSSPFYVEALEWMDLIGGEVSGKLYCPNSKCKSKVGTYDWTGVKDGHLNQYVTPAIMLHQNKSEVYQIGVAANNPLSLLRGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB11</accession>
    <name>I4YB11_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958827.1">
        <property type="nucleotide sequence ID" value="XM_006958765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB11"/>
    <dbReference type="STRING" id="671144.I4YB11"/>
    <dbReference type="GeneID" id="18471576"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32872"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_1_1_1"/>
    <dbReference type="InParanoid" id="I4YB11"/>
    <dbReference type="OMA" id="YHFSHPR"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="171" mass="18931" checksum="271EDD416A738184" modified="2012-09-05" version="1">MMIGQFRLRSLAALARNYRQTRPLSKLIRYPEPSYLEKERSEGLDVEVLPTELMKLTITDSASNQLERISNKEGNTQLALRVAIESGGCHGYQYKLDLLDNFDDSIEKDDYRFSVTDKDNGPSVLVDAVSFQLLKGSTLDFSTELIGSSFKILNNPQAQGSGCGCGVSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC1</accession>
    <name>I4YBC1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_38604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958616.1">
        <property type="nucleotide sequence ID" value="XM_006958554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC1"/>
    <dbReference type="GeneID" id="18472074"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38604"/>
    <dbReference type="eggNOG" id="ENOG502QQWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="InParanoid" id="I4YBC1"/>
    <dbReference type="OMA" id="RSSPHYE"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="464" mass="50427" checksum="F8BE30D5FA0FC9AD" modified="2012-09-05" version="1">MNYNESSILHDFKNFVPGLPIYTTPLSPEFQHSCEFYNRSLTYQPLAVVQPHKAEEISQVVQFCKAKGIPVVIRSGGHDFFGRSLVAGSVLIDMRSMDSIIIEPDRASVRVGGGVISGDLQQVLDSHRLFTPTGQAKSVGYVSWACGGGYGFYVGTYGFGVDQILGARVVVANGDIVDTNEDPELLWALRGAGAGTFGVIVELRVKTYPSPKLYAGLLAFPLSEAANVLAGFEKLLVEGYPDEFSGDAIVARPEMLPIDIAEPCFVFLWCWTAVDGDLAMAKSFLHQMMNLGTVLANTVTETTAAAYGMGKSSSATFFRSRNIDRLQHDIGSILAQGPPSQPLSAVVIHNNHGKGVRDGVADGIGTAFVNRYQHVILGLHGGTNWETVPDSQETVDATVWVKQLENKIDEKNFTLRGGFASFFSPEDIDVVEFFGRKLAERLKHLKNRLDPGNIFCNSLPGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBF0</accession>
    <name>I4YBF0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_57622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958645.1">
        <property type="nucleotide sequence ID" value="XM_006958583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBF0"/>
    <dbReference type="STRING" id="671144.I4YBF0"/>
    <dbReference type="GeneID" id="18472935"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57622"/>
    <dbReference type="eggNOG" id="ENOG502QS1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352033_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBF0"/>
    <dbReference type="OMA" id="VPNKSIM"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="465"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="799" mass="89068" checksum="C5F5053A436DFCBC" modified="2012-09-05" version="1">MQASKTGRHETPVTSLSTSYSNQHPKASSREDSRRIARIHFKQLSEFLETHLRKEAPSSRTSARDKLTRLTRQQFQELSTDVYDELCRRIQGNEGITPRSSKTDSMGAGTTPYLPTKDDFHPKRNQARQKLATLPKTRFKDLASDVYYELVRRYPELLEEQEEQQMQDENREGGEELDKEGEDKSKAEKRNSIQSSRRSSNDLTNNPFNSPLSGGQALLDHNAGTASAPHNRNGSLASTSSLPFTKATPRHSTVSVLQESNDQFDLPPPPAVDRLHHDSLRVDSVDGADGFSSRSISYSSVGNSIPPAPSESQNPFDNQDSRQQSIADFDNSVGDFEPPQSTNPSLTLAPKEGDDHHKTVSSFSNVSLNEFKASLENDMRNEPKRDFSTNLSKRSSDDSLPRETIETREIKDSELAEGTTQPLFYPPPRPAAAASSPLRTTFDNGDTDRLRLEFAQKESRLGRERDELKHQVIQLIEEVKNLGEREEARFAAEEQTRDYIHSLEIQLKELKDKFGFVKSELDRFKRSSGLQPPLPDNNAANISINENGAVAFETLTGLQTAIDDLIVAGRSTSPSLVLNVMKPIVNQVTLIQSDVEAWQNNTDKAESDRVNVLKEKIIATLDNLMTATRNHAMGGGLSPISLLDAAASHVSMTAIEIAKLVGLRQTSSGSVGHRIIDDKSIERSWDDSKNNIEEHSNKVTALIEHVLSSSRQHRNTQLPELSNYLHQIISSTSIITDICHNIKDSEEMFRINTAVDNLHNSNSILSEYSGDEVLEGDTRKKLLSTLISIASNLKDLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBG8</accession>
    <name>I4YBG8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958662.1">
        <property type="nucleotide sequence ID" value="XM_006958600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBG8"/>
    <dbReference type="FunCoup" id="I4YBG8">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBG8"/>
    <dbReference type="GeneID" id="18474002"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60520"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBG8"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="264" mass="29508" checksum="97F7486CDF4CA93F" modified="2012-09-05" version="1">MEQQQKIPVDLKNVVSFLREKSGMKIRNGALSGKRAEYFKGRSAIKALLSPGYAKLKNVPPITTEADANKVLHSIIPFAYFLRVDRGNPIGGKDSPRELKINNQQLFNPDDYYVWLYAGSQLRAMLGSAALVAVIFIGVMFPLWPTSLRIGVWYLSVAVLGLIGVFFIIAIIRLIIYIITMFTASPGVWIFPNLFEDVGFIDSFIPLYEWDYPKKKKTGKKKAKKESKQSTSQENLQPQENVASNNTSAAPSDSDARADSPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBN2</accession>
    <name>I4YBN2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958720.1">
        <property type="nucleotide sequence ID" value="XM_006958658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBN2"/>
    <dbReference type="GeneID" id="18471564"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32811"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_0_1"/>
    <dbReference type="InParanoid" id="I4YBN2"/>
    <dbReference type="OMA" id="APEMRLW"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="39247" checksum="23889B6D1058CB4D" modified="2012-09-05" version="1">MYGQLLCRFFAGFTGATPLSNSGGSVVDVSRPSERNYLFVLFSSSAFIGPVLGPVIGGLLTQYASWEWSYYLTAIWGFVVFLHVGLFVPETYAPVLYREKAKALRRKTGDKRWHSKYDNPDLKETFKIAMVRPFNFLLKEPIVIFFTIYISVVYYLLFGFLESYSVIFGEWYELDVVWIGVAFVPMIIGILLGAVFLIPFCNHYSRIIKEHGSMQPEEHLKPLLVGAVGLPISLFWLGWTTYPDRIPLYAPVSAGVLFGFSLFQVFVGTYQIIMSSYSRYAASALAGFTFVRYNISGGSVMASAPMFRNLTPHWAATLLGIISALLIPVAFVFYKKGPAIRAKSSFAVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS0</accession>
    <name>I4YBS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_57497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958443.1">
        <property type="nucleotide sequence ID" value="XM_006958381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS0"/>
    <dbReference type="STRING" id="671144.I4YBS0"/>
    <dbReference type="GeneID" id="18472920"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57497"/>
    <dbReference type="eggNOG" id="KOG4765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934486_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBS0"/>
    <dbReference type="OMA" id="YECEYCH"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="37298" checksum="CC23E1BF3A96B009" modified="2012-09-05" version="1">MNKRKIEDALTRLDKAFQSEDSVKAESSKRTKKPKIPAELEERLRWFTMTHNLQSRRSKSTDLLKKKEQSDLFSFHNFILRLQSFSLRTYTSKPIELSPPAVALRGWQHDEAHRNRILCSRCKVGFIVDLSGSQANSYQKLIDTYVEAIESKHTSHCPWKYQQCASSTYRIHELSLPPNLAANVIAERARKIDSNLNFSIRVKHPLSNEQVQSLFNAMPEPKPSEDATILAIYGWEYKSTISSSSYLLTSELDVANVSVKPEKVFDVVREHRFYAPQLMPANEGSKNTGVEALLALITRRGRKKEIQESMIVNSVSVGSNTATVSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC28</accession>
    <name>I4YC28_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958547.1">
        <property type="nucleotide sequence ID" value="XM_006958485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC28"/>
    <dbReference type="GeneID" id="18473972"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60476"/>
    <dbReference type="eggNOG" id="ENOG502SADI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2005677_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC28"/>
    <dbReference type="OMA" id="HRIVLMP"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="124" mass="14503" checksum="F94532965D2744EE" modified="2012-09-05" version="1">MGDMITGLISIFQIYLATLLGPPKMVIYRMWFNVVFDILIGLVPWVGAFFDFLFKANLRNLDLIERWLLSSDASARKHKIVLMPQERFLPERSPPDAHIVSDNPPSRTFRREFIDLDDEDYELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC77</accession>
    <name>I4YC77_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FtsJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958266.1">
        <property type="nucleotide sequence ID" value="XM_006958204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC77"/>
    <dbReference type="FunCoup" id="I4YC77">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC77"/>
    <dbReference type="GeneID" id="18473886"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60320"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="226"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="615"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        <location>
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        <location>
            <position position="75"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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            <dbReference type="ARBA" id="ARBA00022552"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="Pfam" id="PF01728"/>
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            <dbReference type="Pfam" id="PF07780"/>
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            <dbReference type="Pfam" id="PF11861"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EIM21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="842" mass="96398" checksum="1A3478B659E62D87" modified="2012-09-05" version="1">MAKDRGYRSRAFFKLAELNKRFNFIEKSRIAVDLGAAPGSWLQNLSSSMPHGSLIIGVDLVPIAPIPRVTTFVADLTTQHCKQLITNEMKGNLADLVVHDGAPNVGSAWLQDAFAQNELVLASLKIAAEILEKGGTFVTKVFRSKDYNNLMWVFNQLFRNVSATKPNSSRLVSAELFVVCQDFIAPQKLDPRFLDPKYVFKDIAALATDTGKGSVHANAHANVFMPEQKRRKREGYEEGNYTQYKEVSAMEFIEGTDPVTLLGTHNAITFKTKEDKKLLKNEDTTKDILANCEDLKVLGKKEFKQLMKWRIIIREEMGLEVRKKDKKEDIDESNIEELPVNPDEQIAEDIERIENEDSARAKKERRRKNEKRTKEVQRMQLKMGAPIDIGLEQDQHLDDDVYIPDQKSKGDIFDLKHTQKHLKGRNIDEIEEDEGSSEEEPEVAKFEDAYEDEEDKLDRLEAQMDGMYETYQEKLGEKDRKHQIKEARRKDKNREAWGGIPRRGDDDEESEESAGEEEEEEEESEGEYGYEAKEKHRMQLDQDSSDEEEVGTSKKPAKKSKVDRKTQDEAAANVWFGNPLFKDVDGIAEESDEEEEEEASVMEEDEDEEEPAEEDEESDGFEVVPQEDDGEMWDVDDEDQDAARQKRIEDTGLITEEAMSLAYRLKNGMTTKSKLLDEGFNKHATNDRENLPEWFTNDERKNYKVHIPITKEAVEALKARQRAIDARPIKKLAEAKAKKKYKAVKAAEKAQAKSETIMENQELTEKEKAMGVQKMINKTKANANKKREVKLVVARGSAKGVKGRPKGVSGRYRMVDRRFKTDIRGMRNAKKRAENNKKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCA8</accession>
    <name>I4YCA8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_51351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958296.1">
        <property type="nucleotide sequence ID" value="XM_006958234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCA8"/>
    <dbReference type="FunCoup" id="I4YCA8">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCA8"/>
    <dbReference type="GeneID" id="18472555"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51351"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCA8"/>
    <dbReference type="OMA" id="VINWGTP"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="259"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="540"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="747" mass="81535" checksum="4DD16F33BFAD15DA" modified="2012-09-05" version="1">MSGKSYSSRVPPPRAPMEGSSAVPSDTLALSNKIFVHPSTFNQDAPAVLVNSKYVFVTAPDPTPEGDPRKVRPGAFGANAVQRQWAQLSLASPVTLTSIVIEDFLESVDIEIGTNKKGYEPANPFNADELQTSFINAYAGLVLSPGQILVMDYHGINLKAVVRNTNVVALMQDTSDPTLSQTGHIMDTTTINFSKEPASLIKLKGSAKRPAANAVISPNFKFEDMGIGGLDDEFGAIFRRAFASRVFPPGLIEKLGIQHVKGILLYGPPGTGKTLMARQIGKMLNAREPKIVNGPEILNKFVGQSEENIRKLFADAEREYREKGDESELHIIIFDELDAICKQRGSTGGGTGVGDSVVNQLLSKMDGVDQLNNILIIGMTNRLDMIDEALVRPGRLEVHMEINLPDEKGRLQILNIQTSKMRENKVMDKDVSLGELSALTKNFSGAEIGGLVKSATSFAFNRHVKVGTMAGISDDIDKLQVNRADFLQALDEVHPAFGVSEEELATVVQNGIIHYSSNIGNILNDGKLYVEQVRNSTRTPLVSVLLHGPPGSGKTALAATIAMRSNFPFIKLVSPEDMVGFNEAQKIAHMNQVFNDSYKSPLSIVVIDQIERLFDYVPIGPRFSNNVLQAILVLLGKRPPKGRRLLILATTSNRPILTDMDALSAFDAQIHVPSISKLRHLDLVLRQVDLFQEEGSQERAIELLKQAQLNESGKLLIGIKRLLAIVEMAKQDPNPAEKFATTLINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCE9</accession>
    <name>I4YCE9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b560 subunit of succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_18482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="8">The heme is bound between the two transmembrane subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958242.1">
        <property type="nucleotide sequence ID" value="XM_006958180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCE9"/>
    <dbReference type="FunCoup" id="I4YCE9">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCE9"/>
    <dbReference type="GeneID" id="18470770"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18482"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_2_1"/>
    <dbReference type="InParanoid" id="I4YCE9"/>
    <dbReference type="OMA" id="MNGIRHL"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000178">
        <property type="entry name" value="SDH_cyt_b560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with second transmembrane subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000178-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="15349" checksum="ECB92C63F6249F9C" modified="2012-09-05" version="1" fragment="single">TEALNESENLALLNRQRNLRPSSPHFTIYQPQLTWLASIGHRVTGVGLSAGIYAFAIGYVTLPFVGAGFDSQSLIELVQSAPVWFKTLVKAPVAAAFSFHSLNGIRHLLWDTGKFLTLKGAYQSGYAVLGLSAISTIGMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCF7</accession>
    <name>I4YCF7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958342.1">
        <property type="nucleotide sequence ID" value="XM_006958280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCF7"/>
    <dbReference type="FunCoup" id="I4YCF7">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCF7"/>
    <dbReference type="GeneID" id="18473912"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60360"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCF7"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="120" mass="13491" checksum="5116A84014225EE3" modified="2012-09-05" version="1">MSYVAKDQKEVEQAPVAQTHKIRITLTSRNVKAIEKFSADLINRAKDKDLRVKGPVRLPTRVLKITTRKAPNGEGSKTWDRYELKIHKRLIDLTATSDIVRQITSISLEPGVDVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ7</accession>
    <name>I4YCJ7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958376.1">
        <property type="nucleotide sequence ID" value="XM_006958314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ7"/>
    <dbReference type="FunCoup" id="I4YCJ7">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCJ7"/>
    <dbReference type="GeneID" id="18471520"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32568"/>
    <dbReference type="eggNOG" id="KOG1317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="InParanoid" id="I4YCJ7"/>
    <dbReference type="OMA" id="AKWRAQT"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="414"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="470" mass="50589" checksum="F7D4DD8029FB5E71" modified="2012-09-05" version="1">MSAISKSEFREEKDTFGPLRVPLDRYWGAQTQRSLQNFEIGGEQARMPVPLTRAFGVLKKAAAAVNMTYGLDERIGKAIMEAADEVATGKLDSHFPLVVFQTGSGTQTNMNSNEVISNRAIEILGGKLGSKDPVHPNDHVNMSQSSNDTFPTAMHVAAVLELNNSLLPNLTTLRNALADKAESWSNIIKIGRTHLQDATPLTLGQEFGGYAQQLTYGIERVEAVIPRLSLLAQGGTAVGTGLNTRKGFDVKIAEEITKITGVQFKTAPNKFEALAAHDAIVEASGALNTLAASLFKIAQDIRFLGSGPRCGLAELSLPENEPGSSIMPGKVNPTQCESLTMLCTQVFGNHTAISFAGSQGNFELNVFKPVLISNLLTSIRLLADGCRSFTNNCVVGIEPNESKIKAIMNESLMLATCLNSELGYDNVAKAAKKAHSEGLTLKDSVLQLGLLTSERFDELVRPELMISPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCL3</accession>
    <name>I4YCL3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958389.1">
        <property type="nucleotide sequence ID" value="XM_006958327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCL3"/>
    <dbReference type="STRING" id="671144.I4YCL3"/>
    <dbReference type="GeneID" id="18471521"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32578"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556478_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCL3"/>
    <dbReference type="OMA" id="IVEMRCE"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19181" checksum="114BC7E896EF380E" modified="2012-09-05" version="1">MCSQESCNTKLISPISCIECSRTFCTYHYHPTTHRCQTSRRLANNGRSAASNNAGLAALKRLGQSNSNTTAKQPPREPQERDTGERKTNKESTSILAKVIPNMERIQAGGPIKTPLASLKHDKRSKSERDSQMRALLDREKKGILSSNDKLRLAEMRALESQSPKARDCKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCM0</accession>
    <name>I4YCM0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="11" type="ORF">WALSEDRAFT_32585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958396.1">
        <property type="nucleotide sequence ID" value="XM_006958334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCM0"/>
    <dbReference type="FunCoup" id="I4YCM0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCM0"/>
    <dbReference type="GeneID" id="18471525"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32585"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_3_1_1"/>
    <dbReference type="InParanoid" id="I4YCM0"/>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="284" mass="32323" checksum="2D7DCC494406DD44" modified="2012-09-05" version="1">MPPKRDAEEAALDNNNDTQKEASSLNKFGLPKKKFYRQRAHANPFSDHQLDVPLHPHHKDWAAHFPAYADELKSRTKGVEMADVGCGFGGLIVSLAPRFPNTLMLGMEIRPQVTQYVHDRITGLRNLAEKGETEMPAKLESQADGKGGYQNASVIRANAMKFLPNFFEKGQLKKIFFLFPDPHFKARKHKARIITQTLLSEYAYVLAPNAMLFNITDVPDLFSWMQMHLEKHPLFERIPDEELSEEDQVALSCVKSETEEGKKVTRNGGGRQWATWRRIPDPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCM1</accession>
    <name>I4YCM1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_64332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958397.1">
        <property type="nucleotide sequence ID" value="XM_006958335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCM1"/>
    <dbReference type="STRING" id="671144.I4YCM1"/>
    <dbReference type="GeneID" id="18474917"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64332"/>
    <dbReference type="eggNOG" id="ENOG502SF37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035134_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCM1"/>
    <dbReference type="OMA" id="DDRTFCI"/>
    <dbReference type="OrthoDB" id="2576477at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29678" checksum="4A8A3225B7DE5091" modified="2012-09-05" version="1">MAENTSQQKLLYLNVGDERTICVLDTPPPPYENNQRASTSATPRVSDEFAPEDAPLLRQHEEYDEEEELVDDDRTVWERYWAGTFSTFQWKALAHLSVISFPLALFAWIFCFVGSVITASLLITLPIGLGFGWVLLVGARAMARLELQIQNYFYPIPNYVIKKRPIFQRIRRVRPFGHVEYETSFYTNSLAMFQDAYSYRSLMYFLLFRPPIALLLLIVSVTVVPLSILLIIPLPVLLRLTTAFGYWQAQYARDVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX1</accession>
    <name>I4YCX1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dihydroxyacetone kinase Dak1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DAK-1</name>
        <name evidence="16" type="ORF">WALSEDRAFT_32383</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958117.1">
        <property type="nucleotide sequence ID" value="XM_006958055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX1"/>
    <dbReference type="FunCoup" id="I4YCX1">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCX1"/>
    <dbReference type="GeneID" id="18471477"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32383"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="InParanoid" id="I4YCX1"/>
    <dbReference type="OMA" id="CGLCLKT"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="11"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="395"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM21813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="591" mass="62477" checksum="1922EB3A29F8853B" modified="2012-09-05" version="1">MSATNKHINDSSETAVLEALHGLCRLNPQLTLDRESKAVYNSNFDKSKVSLIAGGGSGHEPSHSAFVGEGMLNAAVPGTIFASPNTAQILRGIQLASSPLGTLVIVKNYTGDVLHFGLAKEKFAAKNPEAARVTRFIMASDDVSVGREQSGIVGRRGLAGVTLIHKLAGAMAHKGGNIDQVEAIANYVNDHTATLGAGLEHTHVPGTEASQAYLKDNELEIGMGIHNEPGFTKVSPIPPASKLIENMVETLTSTSDPDRSYVNFKNDGTDRVVLMVNNLGGLSELEIAGATGHATSIVQKKGYKVERVLSGAFITSLNMPGFSLTLLKLPADAEKAPATANQLLDLLDLPVNAPGWRWHAAVPPRTEDEYTNDAQTGLTKSSTDTTSPIKTENGDKIVKAIQSAAENLIKAEPEITRLDTIAGDGDCGLTLKAGAEGVLNRIKEGQIGGEDIAKYILEISEVAETDMGGTSGALYSIFFSALAGAIREHKSDIQKASKSALDTLYRYTRARPPSRTLIDPLDAFINAFAGIGDAKKAIEAANQATEEGKKLEAKAGRAAYVGQEGLKEQAVPDPGAVGVTKILEGFFNVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCZ3</accession>
    <name>I4YCZ3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958137.1">
        <property type="nucleotide sequence ID" value="XM_006958075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCZ3"/>
    <dbReference type="STRING" id="671144.I4YCZ3"/>
    <dbReference type="GeneID" id="18473849"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60265"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="InParanoid" id="I4YCZ3"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="24940" checksum="1F4DB8403891A305" modified="2012-09-05" version="1">MTLRLGSQAPNFAANTTHGSLEFHDFIKDSWTMLFSHPDDYTPVCTTELGELAKVEDKFYERGVKLIGLSANDLNSHYGWIKDIDELHNTKLRFPIIADKNREVARLYDMLDALDPTNVDHLGIPLTVRTVFIIDPSKTIRLMMSYPASTGRHFGELLRVIDSLQLGDKYKVTTPANWQQGDRVIVHPSVKNDDLEKTFGTEVEHLKPYLRLTKDPSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD05</accession>
    <name>I4YD05_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_37952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958149.1">
        <property type="nucleotide sequence ID" value="XM_006958087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD05"/>
    <dbReference type="GeneID" id="18472037"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37952"/>
    <dbReference type="eggNOG" id="ENOG502S87A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090067_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD05"/>
    <dbReference type="OMA" id="PGHEHFA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="231" mass="24942" checksum="5963674284605F57" modified="2012-09-05" version="1">MSDANAPLLNSRESTAESPNSVSIDNVALIVALLSALSLVATPAIFILNSGGYGNLGPFVFHPLFQTFGLTVLVIAVLTLQPATAGTRKVRSFERHRKLIGYLALPAFLVGSSAMFYNKHLHGALHFTTWHSTAGLSVGVLLTIQSLVGLGFTMPSKEKPLLPKTLYKYHRLSGYFILLPLLLLTVALGGGHSTWATTQASLTIRVLFVDLPALLIVLSLWARLRKQKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD65</accession>
    <name>I4YD65_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958203.1">
        <property type="nucleotide sequence ID" value="XM_006958141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD65"/>
    <dbReference type="GeneID" id="18475476"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68812"/>
    <dbReference type="HOGENOM" id="CLU_2499614_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD65"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="86" mass="9705" checksum="1D06ABF8FEFE49B5" modified="2012-09-05" version="1">MSAIRRAIVPGLRSYSNKASTSQAKNTPQDQTKGDKVPEKKKSIKEIDDEMISKLKDRDTGQEEIEEGNIEGGLKHHVRAQKFRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD89</accession>
    <name>I4YD89_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_57367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958223.1">
        <property type="nucleotide sequence ID" value="XM_006958161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD89"/>
    <dbReference type="STRING" id="671144.I4YD89"/>
    <dbReference type="GeneID" id="18472907"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57367"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="InParanoid" id="I4YD89"/>
    <dbReference type="OMA" id="DQKSHIE"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="32206" checksum="1B8BF5589390A458" modified="2012-09-05" version="1">MASSNPQVNNNADFRLENLFSTRGKTALVSGGGSGIGLMISQALAVNGAHVYIFSRTQEKLDRVVETYNKGDIDGKITALQGDVSSKESIQKLVEEYSKHESKLDILVNNAGIAGETTTFEAKTAEQLRDNLFNGDSFENWESVYRTNVTSAYFLTAACLPLLNKSTETIKGWSATVLNIISISGSIKISQHHPAYNSSKAAFGYLNKVLANEFALNGFKIRVNGISPGVFHSEMTAGDSSANQKSKVENEKYKKLPSGRVGADKDMAQAVLFAILDQYLNGQSIIVDGGYQITNGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD94</accession>
    <name>I4YD94_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958227.1">
        <property type="nucleotide sequence ID" value="XM_006958165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD94"/>
    <dbReference type="STRING" id="671144.I4YD94"/>
    <dbReference type="GeneID" id="18471495"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32465"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="InParanoid" id="I4YD94"/>
    <dbReference type="OMA" id="TPWHEAF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="20296" checksum="9FA4F09AD8FAA01E" modified="2012-09-05" version="1">MSNRRLVESLQHSTEQVKTQTMQENHPINSTNWWHIYGEAKTAVKDITVDQVADLYINGISGVDFVVVDVRRADLSEMIPGAINLPAQSLPAALPSLVHSLSNIEKFIFHCNSSKGRGPRAAGWFANTLDSHLRSIDPSLSIENRVFVLKGGINAWKDRFGAGSIEDRGRLWDRKTMSTLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD98</accession>
    <name>I4YD98_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958230.1">
        <property type="nucleotide sequence ID" value="XM_006958168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD98"/>
    <dbReference type="STRING" id="671144.I4YD98"/>
    <dbReference type="GeneID" id="18471476"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32377"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_11_2_1"/>
    <dbReference type="InParanoid" id="I4YD98"/>
    <dbReference type="OMA" id="HESECFC"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="126"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="515" mass="59131" checksum="F1E51A7DC0B63B13" modified="2012-09-05" version="1">MVDIEPEFENISLSSSQITATMIPKDNEIDSKLSHNRTRSYSSLQSDKDKDTGLLLRRVDETVHENTQNRQSIERGKQELIHNLEEKEKVKKSSDIDWQFWGEVMANYEEVARTQPHALSKAIQKGIPKELRGMVWQLMSSSKNSELETLYQEYLKLSSVNDKTISKDLSRTFPALEYFQDPDAVNWLFNVAKAYSLYDVECGYTQGLLFVIGPLLLNMPDEEAFCLLVRLMQSYDLRGHYLPEMPGLHLRLFQFDRLLEEILPLLHTHLTRQGVKSSMYASQWYMTLFSYRFPLDIVYRIFDNIFAEGIEAIFRFGIALMKKNEDKILSLQFENILDFLKEGLLEVYRIPQGEGSQRGSEALQAPLLKGQSHSSPHSSMTGSVSPRLATSADSGEWDCDTFVADAFEIRITPFQLDAYASEWAETCYNINKHAHEVDGLRLANRNLSSQIKKLEASLTQINGEHCELVKTLVNLRIEKDEMEESLVNQLVKMQVENAASQDELKKTQEQLSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDI2</accession>
    <name>I4YDI2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial import receptor subunit TOM40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957832.1">
        <property type="nucleotide sequence ID" value="XM_006957770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDI2"/>
    <dbReference type="FunCoup" id="I4YDI2">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDI2"/>
    <dbReference type="GeneID" id="18473762"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60134"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDI2"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="38865" checksum="C0234543AA9014C4" modified="2012-09-05" version="1">MSGYQQVAPGEAAPVLQQNEVAAKLHPEQPKSASESVLSPITSTYNRFMDWRKSLNLGSPGTAEAMGREAKTTLLSNFIFDGARADLTKGISLNPAFQVTHSFSLGSQQAPPNYSFGAVYADAKSFLQGAVDHTGTLTGRANQSFANLGTGKIQAQLSEVPGQSMIQLEHDYQGLDYSINGKAMNPSLVDGTGIYIGSYLQSITPNIALGLETLVQRPQPGISESLTSYLVRLSGSNRDWLATAQINPSGMLEATYHHKLSDKVDAAATLQVINRPQGKEASASLGAKYDFRMASFRGQLDSTGKVSALLEQRFTPAFAFLVAGEIDHLKNASKFGVGIMLESTTMTPEEMNAAMQSVPQPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDS9</accession>
    <name>I4YDS9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957923.1">
        <property type="nucleotide sequence ID" value="XM_006957861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDS9"/>
    <dbReference type="GeneID" id="18474874"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63863"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275105_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDS9"/>
    <dbReference type="OMA" id="QSEIVAM"/>
    <dbReference type="OrthoDB" id="3351349at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124781" checksum="D0478225E5B28FF2" modified="2012-09-05" version="1">MQPRSRQTSFGSNSAKSSSPGPPLQFSAPAATRPSGGRLSGLLKPFTPISGQQNKQGYAPPPGAPPSRRGSVNNTQHPAGLSNLATTPSAVYSSSSSPLSYAPRPRSYTSNPYVSADIRPASPRTSVGQMTPAGERARRRSTAYQDQAPQRKGSLAQAQGLEPLKPRKSFFGAVNGIEQPENPEEDVLGDAIRSFALAWEDLFGTTDVENTLINQLFGCVKGLKDASKELSVILLTSFHAKSIVDKAKVVVALDQFTTVLKNAGQLFYSKYPLTIHAANLNQTLHEIAQDKEFHSIFLSALEPLTVLLEMTTDLRRKLVFVVLDALAGGNQSAHLRSTLLLFRNILQMLTGSQVAPAIYALGEFIIALEQVLTEAPALIRSSIAEPLQEKNTESTDTFSSLLNAAIEARATAEPNVELHSLGYSYIPANCTTRVGIISNRFKPVLSEKLPSNALAYEFGKLTEAIGGNSRIARVKRAIASIRQYAPYGKTLIEIARQATKNFVNVQIDKFEGEDNDFKYAFSNVNLVLSTLVPEDFSLDSHSTISFSQSLSFTPNTGIKASLRGLKFSAKSLKYNYSQKGIVGVSDEGTADLEFTADLVINLNATGQFQGYDVNVHTIKFDVNGGEGIKANIYKTFWPYVQSRVAVTINESVRKYIDSNIKSFKSMFDINAPAGGTPAVQVDGPSDVAKQFFQTPRQRKESIQAAAYASSSINPAYAQHPVGARDAFRAEIEKHPELRGNVMRQLENPFSGPPSIGGSRRNSHSHEEQPTGPRRKSMADSLTQTSMADATLTENIHKPKVDHTSLVGADVEGYENMSSALSAAASVDTTGYNAIRDPIIAPEADAETAQAALLRRGSRASVSAVGESATLSDYPVEAHDNTRPHLNEDYPAMSMSLNKRASMDATQFENIQNPPRAEREDTGYAEAQSMSMRDRALSLSGQEVNPTDKFIPVDRYDYMKYGDSAVEDDEEIERGPGPEKQRMMSQSIPKELTVDNTLVENRVRQQEGKPSANAGIPTEQWKGRRMSAALNDEAKADATLRENIASPPQSRSNSITRRKSRPSMTSIKKASMSEMSLNDEVTKDNTILDPNEKVPKGDRRRLSRPDNDELDGEGRGGPGTGASKTKRRPSMAEMLPEDMKKDQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW7</accession>
    <name>I4YDW7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Cyc8p</name>
        <name evidence="11" type="ORF">WALSEDRAFT_60186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957958.1">
        <property type="nucleotide sequence ID" value="XM_006957896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW7"/>
    <dbReference type="STRING" id="671144.I4YDW7"/>
    <dbReference type="GeneID" id="18473801"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60186"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006762_1_2_1"/>
    <dbReference type="InParanoid" id="I4YDW7"/>
    <dbReference type="OMA" id="ACVYERC"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="856" mass="95288" checksum="8A161C2389688655" modified="2012-09-05" version="1">MQRSWPANYVVQTPILRKLALANEDAWLTAAATAESMNDAERALVSYQNALVHSPYSVPALSAVGAIYRQRENFPKAIEFYQRALNVQQDNGDIWSALGHAYLMIDDLQKAYTAYQQALYHLPAPKLQDPKLWYGIGILYDRYGSLEHAEEAFAGVIKIAPDFEKANEIYFRLGIIYKQQQKFSTSLDCFRYILTSPPKPLSEIDIWFQIGHVYEQQKEYTLAREAYERVLIENPEHAKVLQQLGWLYHQTSATNNNDQELAIQYLTKSLGVDPTDPQSWYLLGRSYMAGQKFNKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWFDLGSLYESCHNQISDAIDAYARAADLDPTNPHIKQRLQLLKNVQANGGSVPAAPVPQDVHPTAYAQPQAVSSSTANSEGQTPYATIESADSVQQQQQRMTQAHGQPQSQVPSVSSVSDVEPTAPNGAAGQPVPFSAGLPGRQLNLPRDAPMPVQRSEQQFVSYTPAHYEDGRPVVDWEGRPVSVQRFHSPVPKEAIKRNSSILSPPPVNSHPPHLSQSFERTGNGTTSRNSRYDPRMDGAPSQPVVSNPHQESPPRLTPKSVKGRKSLAFHAQRMEDSAYTPPPLGQEASSYTLHHKKPTRPRPSIESPASSRRASATTRLAPVAQPSTSSIHNNGRYSQSPQSEDDTNAAAVPPVTRVVDEDYDEGAADALMGLAGAAAASDRQPIPPNIREPLEKENGPNHMIGVKRNTQDGQNDPNKRQREDKNGSLSPENDPAAFPRKHSMNTMNTPPADDTNEDDELEGAEDSKDAVKEAVDAHNGEQQQQPQQQQLQEPQARPVDQEMRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE01</accession>
    <name>I4YE01_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957988.1">
        <property type="nucleotide sequence ID" value="XM_006957926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE01"/>
    <dbReference type="STRING" id="671144.I4YE01"/>
    <dbReference type="GeneID" id="18473808"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60199"/>
    <dbReference type="eggNOG" id="KOG4493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069661_1_1_1"/>
    <dbReference type="InParanoid" id="I4YE01"/>
    <dbReference type="OMA" id="VCWEIWT"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="25389" checksum="3C41025FCA1D0B80" modified="2012-09-05" version="1">MTVTKTLTITVDKAYLEDVCAGILHSMLFQRTLGNFKPKELAVLDVPMPAIESASIGQLVQRYAQELSATSTDRGVLALVLAETQSRRTNHWFGFGEQETTTQVPWETWIVNFNILISKSENHKQILYTNTQNDLQKALLQILAFADERKDHIPPIMTADLTPFPFHIVVNPPEGPPTRSGSPQSLAVAEVNRVLSGEKHQSPNSYFSAPLHSIAKRITSSNNSEENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE91</accession>
    <name>I4YE91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_59992</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957543.1">
        <property type="nucleotide sequence ID" value="XM_006957481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE91"/>
    <dbReference type="FunCoup" id="I4YE91">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE91"/>
    <dbReference type="GeneID" id="18473670"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59992"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023995_4_0_1"/>
    <dbReference type="InParanoid" id="I4YE91"/>
    <dbReference type="OMA" id="IMGVACT"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM22283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="371" mass="41979" checksum="3149DD04EF17C734" modified="2012-09-05" version="1">MTTADNEKNKRNASPLPSPSAFIQRLNSYSKHGFDIPDHIRVKFAPINVPRHRRLQTAAVATWALILPISFSLFLLCLSFPPIWPILIPYLIWAFLIDNAPEDGGRARKWFRDSRIWKFFAEYYPVSMVKEDELPSDKAYVFGYHPHGIIGMGALANFATNATGFSSLFPNINPHLLTLTANFQVPFYRDLLQSMGICSVTKRSCERILRKGPGNAITIVVGGAAESLNAHPGTSDLILKKRLGFIKIAIREGANLVPVFSFGENDIYQQLATEDGSTIHKLQKTFQKIFGFTLPLFHGRGIFNYNLGLMPYRHPIVSVVGKAIEVEQTSNPSQEMLEDVQSRYIDELMRIWDKYKDIYAANRTRELTLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE95</accession>
    <name>I4YE95_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum-derived transport vesicle ERV46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957546.1">
        <property type="nucleotide sequence ID" value="XM_006957484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE95"/>
    <dbReference type="FunCoup" id="I4YE95">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE95"/>
    <dbReference type="GeneID" id="18473671"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59995"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="InParanoid" id="I4YE95"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="407" mass="45622" checksum="1AED779FDC1D651E" modified="2012-09-05" version="1">MPKSGFMGFDAFAKTLEESRIRTNFGAYLTIICAILISFLTFNEFRDYRAVDFKPRIIVDQSRSEKLQLNFNVTFPRVPCYLLSLDLMDVSGEQVRDLRHAIVRTRLSEKGETIDGMKTAGMSGYLNEVAKPRECGSCYGGVPPNEEKCCYTCDDVRESYVKQGWSFVNPDGVKQCLDEHWAERVKEQSSEGCNVAGLVDVNKVVGNFHISPGRSFQSNAHHIHDLVPYLKNANNHHDFGHILHHFSFKSSNEPADTDNLKEMLNINDPLSNTKAHTEVSNYMFQYFLKVVSTDFDFLNGEKLNSHQYSATAYERNLDEKGIYAQDGHGQTILHGVEGFPGVFFNYDISPLRVIYTESRRSFASFLTSTCAIVGGVLTVASIIDAGVFGARQKLTGKTHSSADGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF4</accession>
    <name>I4YEF4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957601.1">
        <property type="nucleotide sequence ID" value="XM_006957539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF4"/>
    <dbReference type="FunCoup" id="I4YEF4">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEF4"/>
    <dbReference type="GeneID" id="18473692"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60027"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_12_2_1"/>
    <dbReference type="InParanoid" id="I4YEF4"/>
    <dbReference type="OMA" id="VYWIDLE"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="648" mass="72422" checksum="9B24FEBE2741EED0" modified="2012-09-05" version="1">MSPNNKQDSHNDQVTPPRSPSSGRSSYRRLNDEERQRQQDIDSVMQLSRARAGSYIQQTPSYSKRPRNETLLNADPQEDDPGLSPNTDKPQFLFPLSSDEEAQIELAKHGGSLDLDNQDLNEKLSPHSSDVAIEQPQIHPPPLSAQPSTELLSAGTRLKPNKFDFALLDAYVAAESTGLEFSEKDHSGLTPPSTPKQPDDNKKQSAHQRHLAIFDSSGAPPPTFPSGSSPPPPPLPAPSNDPYNTTPRPHLPPRVPTTTEKEYRFSFYSNALPATVHARSLGELPSVGQTFRQLFEGKPQASSATLSDPTDSNALELNMGGNNGNEESLDDPEANTWWLDVLSPTDSEMRTLSKVFGIHPLTTEDIQMEEAREKIELFRNYYLVCFRSFDQDPHSPTYLEPLNMYIIVFREGTLSFHFRATPHPHNVRRRIKQLRDYINVTSDWISYALIDDITDAFAPLIQSIEFEVDTIDELVLILKENEQSDMLRRIGTCRKKVMGLLRLMGNKADVVKGLAKRCNENWTVAPKSDIGLYLSDIQDHLITMTQNLNHYEKILSRSHSNYLAQISIEMTEANNQINNVLSKLTALGTVLVPINIVCGLWGMNVSVPGQNAEGLTWFFSILGILVAVCIACGTLTYWLALKPPKPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEM2</accession>
    <name>I4YEM2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957660.1">
        <property type="nucleotide sequence ID" value="XM_006957598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEM2"/>
    <dbReference type="STRING" id="671144.I4YEM2"/>
    <dbReference type="GeneID" id="18474855"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63611"/>
    <dbReference type="eggNOG" id="ENOG502S2FP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550058_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEM2"/>
    <dbReference type="OMA" id="VNDTWFG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="51578" checksum="5E062406DAEDF01D" modified="2012-09-05" version="1">MATPTPYPESYSNKIPVTLPSERNKVRKRTSRNDYRRVNKPAYGDGYFGRLGKRYGAGTAPDNEGYPECDNVSNSVVTCYPDADTSIRSGDYSKLIWNPNLPQFTESGDLDIYLFSADTEQVVQSWKDVPNQRGSQPINPGDDWWSPIDDGWGPYDPENSSQWADTTRDWTYYAVLVPAGQSLSGGEEHQATFTAVQTAPLQNLVASSSSSSMSSASSQSSISSLSTASLASASATQSVVSSVSSVSSASMASLSSISQSNSELYSSMTRSSQSTRSVLSTAATMSAITTTDSNGDRVTSSVRSTPTGVLQDNGDDDRFPAWGIAVIVVLGVLALLGIAGAMYLLARHLRRTHGAAAAAEAGGAAGGANTPTQSEPLMKENQPNDGLLAAGGGAAGGAAGAAVGAAALGARSASSERSSAENDNGDGPITSNEAAAMADAFRQALRSPEFDSGSNSNKLNNSDPNTTESSNQGLTGIQENSVARQPELVNASDGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEY5</accession>
    <name>I4YEY5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_63168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957199.1">
        <property type="nucleotide sequence ID" value="XM_006957137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEY5"/>
    <dbReference type="FunCoup" id="I4YEY5">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEY5"/>
    <dbReference type="GeneID" id="18474815"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63168"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1679323_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEY5"/>
    <dbReference type="OMA" id="ANEMAPQ"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="157" mass="17911" checksum="21FDF6DC94C0846E" modified="2012-09-05" version="1">MSNTANPLAFYQSLYSCQVAADSCVDEADEALRQLRDGLSDVARFKQISEFNRHFILISESEVNNAKSSLAADIEPQIRNLTTRAETALNNLLIRQDQLKHKAIRRQELAYNAKSNLSPEDAGILQKLSLQKERYQVQIADEEAQLRELEEKLQNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF16</accession>
    <name>I4YF16_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Endoplasmic oxidoreductin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59827</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957228.1">
        <property type="nucleotide sequence ID" value="XM_006957166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF16"/>
    <dbReference type="FunCoup" id="I4YF16">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF16"/>
    <dbReference type="GeneID" id="18473571"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59827"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_1_1_1"/>
    <dbReference type="InParanoid" id="I4YF16"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698069" evidence="19">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="141"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="390"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM22558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="518" mass="58714" checksum="1F08DCAB5E124146" modified="2012-09-05" version="1">MRFNSLLSAGLLLNSVYSTPSKQPISKQVKNVLEHQPDSDKYCSPSGQIEDACCLYETIEEATDKVYKPLDQLVRTPFFRYFKVDLYEDCPFWYEDTFCMNRDCGVQSEEDESKIPEKWRANALSSVNDVQEQDDSSHPACSARVSDFCYTPDEASPSAVYVDLARNPERFTGYSGPSAQRVWDTIYKENCFGVAEFFESSGRVKSGVTEVSQAPASMGLLIGPGGSFGSGPTLEPDFEIDNDDENEMCVEKRIFYKLISGLHSSISMHICSEWLNQETGEWGPNLDCFISKLSDYPERVQNIYFLNAVLTRAIARARPLLEAYDTSVGERLADEQTRGYMQDIMNHVDSCDDTFEEGTIFEGGPAKQILKEEFKAHFRNVSRIMDCVGCDKCRLWGKVQVSGIGTALKILFGLDGDDFKEPNTLQRSEVVALFNTFHRISESINNIEVFRELYEERKGQEVIADPIDVPIDFKKVDYMSTLSGILMSLKGRLQTLQDYLRIAYERLLVEYAKATREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF17</accession>
    <name>I4YF17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957229.1">
        <property type="nucleotide sequence ID" value="XM_006957167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF17"/>
    <dbReference type="FunCoup" id="I4YF17">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF17"/>
    <dbReference type="GeneID" id="18473572"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59828"/>
    <dbReference type="eggNOG" id="ENOG502RZNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055179_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF17"/>
    <dbReference type="OMA" id="WEQPHRL"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="398" mass="44971" checksum="236FC669D406B7DC" modified="2012-09-05" version="1">MSGNKKTTRKSEPFVAGDVNQKYNEGDIVLGKIKGYPAWPGKIMNSEAVPPLVKKDKPKNKKNVYAVRFYPTGEYMWANTKEMSALTKQEIENYLNDTSKKREGDLRKGYQVALNPDEWEEEHDRRLADAQAQADDDELEDEETGSKRRRKAPAKGTTKKAKTDASQKKSKSNKADASDAEETEEAKVRSWRHELQRIFLSPEPAKADAMPKADAQIKVIEADDDVSAESITLSKVNKVLKRIIGLETIPEDEKYKIRERSQALYDRFEKILAEASEKDGEKKTNGEEKKENGEKKPEEEQKDDAEVAQATEDTEKKDQTLEKTEGDKKEESDEKSGEGEKKDEEKNEEKKDVEMKEDGKPEAPEEPKEPQEAEQSAVEAPKSGEESAEKPEEKSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF32</accession>
    <name>I4YF32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_59839</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957244.1">
        <property type="nucleotide sequence ID" value="XM_006957182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF32"/>
    <dbReference type="FunCoup" id="I4YF32">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF32"/>
    <dbReference type="GeneID" id="18473580"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59839"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000914_3_1_1"/>
    <dbReference type="InParanoid" id="I4YF32"/>
    <dbReference type="OMA" id="IQERWCC"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="16">
        <location>
            <begin position="223"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="921" mass="105422" checksum="329FF828BAAAC6D4" modified="2012-09-05" version="1">MDINSDVRLVLGVAALDRKARSKPMRSILNRIMKISNIEICIFGDKVILDEDVENWPLCDYLVSFFSDGFPLDKAIDYVNLRKPVCINDLTMQKLLWDRRLVLSILDSIGVVTAERISVDRDGGPNIDPQLAEMLQKDLGLSFPKNPHQPEVKLREDGDAIIIDGLELEKPFVEKPVSGEDHNIHIYFPKSQGGGARKLFRKVGNKSSEFYPEIEEPRYDGSFIYEKFINVDNAEDVKVYTVGPSFVHAETRKSPVVDGIVRRNTDGKEIRYITELTADEKKCATNICKAFKQNICGFDLLRYDDKAFVIDVNGWSFVKGNDYYYDKCAEILSTFCRKTAPKRPITAVHNNSPRDKSSWRLKANATVVRHADRTPKQKIKFSFQASEKWAQPFIRLLRGATEEVILRRAEQLNYITEAADEAVKLGCNELEKLEQLRIVISKKIDLPGTKAQLKPNFNKNDGVTLEKLALVFKWGGEFTHAARYQSRDLGFSFRGDAMIMNKDMLENCKIYSSSERRVLASAEIFAAAFLEDPEKRKEGKEPITHPLIVRKDLLDDSNAGKDMMDFVKKKLKTLLRPGEKEKRPQFQWPKDLKGEPVEVVAEIIELMRYHRDVMRSNFENLEVDKIQTRWCCNEHPLLFKERWEKLFDDFCESTTQEKFDPSRISELYDSLKYDSLHNSVFLNTIFRPDGKQDPNDRRLHSLYGHAKALFDLIAPQEYGIEAEEKEQIGILTSLPLLKKIVQDLQEARDAEKGAFSIYFTKESHIHTLVQLVLCSGLPITMPHVPELDYVAHLTLELYERSIGGAHREKEYSIRLALSGGAHTSNVLDSQLDAKHSLNVQPRRQLTHHLDYDHAIKMLSKHFDKDWVFSTTPLEGDALYGIKDDHIEQIREVRLNGGASTPRKHESFGDDSSTKSGTSQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFC7</accession>
    <name>I4YFC7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957334.1">
        <property type="nucleotide sequence ID" value="XM_006957272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFC7"/>
    <dbReference type="STRING" id="671144.I4YFC7"/>
    <dbReference type="GeneID" id="18471379"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31863"/>
    <dbReference type="eggNOG" id="ENOG502QUAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493645_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFC7"/>
    <dbReference type="OMA" id="QFISHAT"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="289"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="552" mass="60469" checksum="6E49235286E25414" modified="2012-09-05" version="1">MSPGINSNSRATTSSVLPPKLNQRAASSVTVQQRSRENTQSTVDSVAPTSEDSSTKDKAKSPEALRRLTSSIMLTAVDNPAHVPPPTELPSRTSSHKDVTVLGSAAQASQKLSVASPKIYGRQMSRSLTDLSSFQSPEITEGLPTGLHPSVSAGADVSAKGKEKAEPQTPAITIDQAVESSTSTREIAVGTSPPVTPAMGHTVQMEQERLNWKDVVQNTPLSPPPPLTPLSTHGSPSAGRRRMSLPNMTVAPPQYEDVALRETIFGGIRRVIRPREEEGNEKLPTYKCGIHIEGLMPRKMEFTSPGNQARDRTWRRVYAVLHGTVLKVYKADRWDHDRAVLSSEINDLNEADQESAYVHQPPPADAPIPPVPALPQLLAQRPSFQNHINAPPNNIRYAPTLLRSYSLQNAESGLAADYVKRRNVIRVRLLSDKGVKEQFLIQAYDQSSVIDWIEALQAATNVSLDLDSRPMPKLTTLPRRRRRRRVRQEDLSNGNTDAIEAAQTEAAIQASLRNNQNADNISTRSGGLRANIRNSIRRNASQLRSTTSVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG07</accession>
    <name>I4YG07_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_43755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956947.1">
        <property type="nucleotide sequence ID" value="XM_006956885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG07"/>
    <dbReference type="FunCoup" id="I4YG07">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG07"/>
    <dbReference type="GeneID" id="18472303"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43755"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_1_0_1"/>
    <dbReference type="InParanoid" id="I4YG07"/>
    <dbReference type="OMA" id="YFYKYYK"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="103" mass="11575" checksum="0006E1278952D2F1" modified="2012-09-05" version="1">MSAKFEKAVSIVNSLPKEGPVQTSTDQKLRFYALFKQAKEGDVKTSRPGMMDFTGRAKWDAYKSVEGMSQEEAANKYVEALLEILKSNDSEESKKYINEIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG90</accession>
    <name>I4YG90_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_67862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957023.1">
        <property type="nucleotide sequence ID" value="XM_006956961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG90"/>
    <dbReference type="FunCoup" id="I4YG90">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG90"/>
    <dbReference type="GeneID" id="18475309"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67862"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_4_1_1"/>
    <dbReference type="InParanoid" id="I4YG90"/>
    <dbReference type="OMA" id="WKRLRPQ"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="54745" checksum="841AC13BC695448A" modified="2012-09-05" version="1">MQTISLNQPTIEHKKALEALNSKIIKSKRIIIVSGAGISCSSGIPDFRSPEGLYALVKDKFDGKIGKGQDLFDAQLFRNPSTTALFYSFIAQLKLASDNAAPSPTHKFLKTLEIKGRLLHSYTQNIDGLEQRVGLKNLVNLHGSLNEVRCASCSFVGEMSNDYLNVFANGQSPKCPQCASRANERNTRGKRPLAVGCLRPGIVLYNENHWSGDSIAKAQTADSKKKPDLLIVMGTSLKVHGLKQLVKGFARTIHQNNLDINEKSRKMPGNVVFVNATPAAGKEWSSDLDYFVHGTSDDFVNRLVNQWKATRPQDWQVQTKITQTHNVAKSIKPATAKKTLPPSGDSNEDSKNSDGPSEPVIDENQISTGFDSQQQRSCHQPEQHKESPMKSLQEINSLDTLQVSPKSRKRNTVTSSTIKRSVSSTQKSSMDVSILKKNKSEDFAINFDLKIGDGSETEPEEDTVETQPTNLSPVVFEPARRSIRIRNHFTTVTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGG9</accession>
    <name>I4YGG9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957095.1">
        <property type="nucleotide sequence ID" value="XM_006957033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGG9"/>
    <dbReference type="STRING" id="671144.I4YGG9"/>
    <dbReference type="GeneID" id="18472836"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56687"/>
    <dbReference type="eggNOG" id="KOG4444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781194_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGG9"/>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="355" mass="38990" checksum="C668ED85BDB45113" modified="2012-09-05" version="1">MALLPSVDNEIDRAFKVQTITEELKERSKSSTLSSSGVISEKSLAPSSDNDTGSAPAMQTGPLSTDSSALSFNDQSTTASSNGDSSPDLPKSPSKISELKLKSKKDLWEDLKVGTFSQSITIHYAVTLLSLLTHIQLSHLGREAYVAQLRALARSRAPVPFDSVDDNDTYDKTYLSLTWWFIYTGLPRLSQRVKAAVDEIIGPATLRDLVDGDSINVWIDQVRNAIEGGPIEELLEDLFPMTDKSLMVTLDNNHQLNTGELFIDLVQQTRDSLQTADFKKILSECLNKNFSSLSASISQLQEGKLASQLPKIKKLGQSSLQSVPNDLVENVSNCDDLLTLDALIQTNYETSIDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGK4</accession>
    <name>I4YGK4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957129.1">
        <property type="nucleotide sequence ID" value="XM_006957067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGK4"/>
    <dbReference type="GeneID" id="18472839"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56709"/>
    <dbReference type="HOGENOM" id="CLU_814327_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGK4"/>
    <dbReference type="OMA" id="RECEQIH"/>
    <dbReference type="OrthoDB" id="3363186at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="34860" checksum="360F47EF7C856DFE" modified="2012-09-05" version="1">MTPTTTTKKEKSKEHQFVENLEDIPNLIEDESPMQPQTIEQSQPEYHENVNEQIKDNTNSSVLSGTTSKYIRKVNVGKVGGMSSYIDYKSNKDAKKLLNVILNDLDKKWDAKALMFKQVAKAQRSLRKKSEEDYKVLSQKYHRLISDYDLLKKTSEDVSKFMPKDIQVLRLHIHEAEDRLAAHHASIQPLNDELNETKGKNAEYLDTIYHLDGKLNESDGQLAIARNHLESAQNDSSLLRIQMETLREQQRENEAIIASLKASKEVQGLIENFNPITAILVLTVAYLLACVLGLAADPIKIAMISTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGS4</accession>
    <name>I4YGS4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_62542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956562.1">
        <property type="nucleotide sequence ID" value="XM_006956500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGS4"/>
    <dbReference type="FunCoup" id="I4YGS4">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGS4"/>
    <dbReference type="GeneID" id="18474759"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62542"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045732_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGS4"/>
    <dbReference type="OMA" id="NPLHFQW"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="36559" checksum="3D248719715C0F71" modified="2012-09-05" version="1">MTEYDDIDALAVLGVTEEASEAEIRKAYRKRSLKVHPDRNPDNPVAAEEFHKLTIAAEILLDPSKRIQLADVAKAKKAKAERFAKFDTRRQDLQADLDRREKEALEERKLAQKQKRDAQSELERVREEGKRRRMDKTQQLNQDLERESKLNLDKDPEESSPQDKVIRLKWTRKERPNWSGDVIESNRDAIFAILSTFGKVNQVVLPPKKEFTASGKKPKSSSAIVEFDDLVGAFGAVQSSKRGVLDGVSVDWIGGVEPSSIQELRDSGRLHGKSENTSGDTPSFDFTIPVPNSKISYESETLMRMKERERLRQQILEEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ2</accession>
    <name>I4YGZ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">WALSEDRAFT_15285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956501.1">
        <property type="nucleotide sequence ID" value="XM_006956439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ2"/>
    <dbReference type="FunCoup" id="I4YGZ2">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGZ2"/>
    <dbReference type="GeneID" id="18470656"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15285"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGZ2"/>
    <dbReference type="OMA" id="QCHLGAK"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="285" mass="31346" checksum="24256158D6BFC589" modified="2012-09-05" version="1">MSALQMTSEDVSLLLAAHCHMGVKNVEKAMEPYVWRTRKDGINLINLGKTWEKLVFAARVIAAVENPNDVAVISSRPYGQRAVHKFAAQTGAQAIAGRFTPGSFTNYITRSFKEPRLIIVTDPRVDHQAIREAAYVNIPVIALCDTDAALKFVDVAIPTNNKGRHAIGLIWWMLAREVLRLRGSISRQDKWEIMPDMFFYRAPEEVEAEQAALAEAKLLAASGEGRNADAEAEGAQQIPEWDVQAGIQSNDAVDWAADGSLGNTDWAAEATAVQEGQASQQTTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH17</accession>
    <name>I4YH17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_35703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956649.1">
        <property type="nucleotide sequence ID" value="XM_006956587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH17"/>
    <dbReference type="FunCoup" id="I4YH17">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH17"/>
    <dbReference type="GeneID" id="18471926"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35703"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_3_2_1"/>
    <dbReference type="InParanoid" id="I4YH17"/>
    <dbReference type="OMA" id="CTTHFWG"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="117" mass="13308" checksum="751F77402E1DE2C9" modified="2012-09-05" version="1">MSTFSRLLNWSKSPQAREYFFSTHFWGPVANWGLPLAALADLRKDEEIISGTMTATMVVYSTTFSRFAWRVSPRNYLLLACHATNAITQSVQALRFTNYWYFGGREKRGIKTGAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHD5</accession>
    <name>I4YHD5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_67638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956758.1">
        <property type="nucleotide sequence ID" value="XM_006956696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHD5"/>
    <dbReference type="STRING" id="671144.I4YHD5"/>
    <dbReference type="GeneID" id="18475275"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67638"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029481_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHD5"/>
    <dbReference type="OMA" id="NICKSEV"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000585">
        <property type="entry name" value="zinc finger protein 784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="495" mass="56081" checksum="D1DD34869758C3D3" modified="2012-09-05" version="1">MNGLSNGMSTELPVYDEGLALSIMNALSDNKSLKNEDDQGSECSSQYCDDEQHQVDVVCDDDNCVEPVCESEEQFQSFLENCCNNIEFHTNNHQPLDIPQTTQQPQTAPLIKCEWAGCHANFGNMNDLIQHVHQSHLNFVNIDCKWGGGDCHVGPPSTSTNTQTDANAVLKHVLQDHLHMEDNPLAFKKPTENFFNGDLFSTDFSGMDDTSIATAHHDNPELNPYAHHLHATAFPHLHPPSICPAATSISPTPKKHPHPPKPHHHHHYHTPHYHHHPYPRPRSSSMQGPPYKCGWDNCKHADTEFETTEALMNHLSNEHVGSGKAEYACFWKGCDRNSSNCNGRVFSSRQKIMRHLQSHTGHRPFECPVCHRFFSEAATLQQHMRKHTREKPYVCDYEGCGKAFAIAGALTIHKRTHTNERPFKCTYCDRAFSESSNLKKHLRTHTGDRPFECPHPYCDKKFARPDQVTRHLNVHYKQETNKALRNPSPSTSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHG1</accession>
    <name>I4YHG1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_67659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956780.1">
        <property type="nucleotide sequence ID" value="XM_006956718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHG1"/>
    <dbReference type="STRING" id="671144.I4YHG1"/>
    <dbReference type="GeneID" id="18475279"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67659"/>
    <dbReference type="HOGENOM" id="CLU_172736_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHG1"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="7960" checksum="E1548FCC90993649" modified="2012-09-05" version="1">MRDAIQIFGQKVLNEYLALGTIGLTGGIAYLASSGESKPKPAPVAAAGSAEPSKEENEFIQNFVAEFEKSEKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHH4</accession>
    <name>I4YHH4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitochondrial ornithine carrier protein AmcA/Ort1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956793.1">
        <property type="nucleotide sequence ID" value="XM_006956731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHH4"/>
    <dbReference type="STRING" id="671144.I4YHH4"/>
    <dbReference type="GeneID" id="18473448"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59602"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="InParanoid" id="I4YHH4"/>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="310" mass="33073" checksum="1DD4C66BC2A5E3D8" modified="2012-09-05" version="1">MVSSEAGSASALRDIAFGSTAGMIAKVFEHPFDLIKVRLQSQPLDRPARFLGPIDCFKQTLAGEGFLGLYRGLSMPVIGSMVENATLFVVYNQAQDVIRSMSAIKSGESLSLGQLGIAGGVAGGVTSFVLTPIEFIKCRMQVQMLSHMASAQSPHPAKTKVPGAVSLFLDTLKTRGASGLWLGQTGTFIREAGGSVAWFGAYEFLSRSFLPNGSTDKSQLKTWQLVTSGAIAGVSYNVICFPADSVKSALQTSDELGGQVVKKRFFQTGMEIYRSRGLAGLYAGMGVTIARSAPSSAMIFTIYEFLNQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHJ0</accession>
    <name>I4YHJ0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_31503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956807.1">
        <property type="nucleotide sequence ID" value="XM_006956745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHJ0"/>
    <dbReference type="FunCoup" id="I4YHJ0">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHJ0"/>
    <dbReference type="GeneID" id="18471315"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31503"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="InParanoid" id="I4YHJ0"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="24484" checksum="DBA5F4798B292AF0" modified="2012-09-05" version="1">MSTSENLPPNAYRLPRSNQLEGLMTIIRDKNTSRGEFIFYSDRIIRLLVEEGLNHLPTLPKQITTETGEDYDGVGFEGKVCGVSILRAGEAMESALRECLRSVRIGKVLVQRNEETGEARLYYAKLPEDIHERFVLLLDPMLATGGSAIRAIEVLLSKGVKQDKIVFLNVLSAPEGLKVMYEKYPKMKIVTGWVDRKLDERNYIVPGLGDFGDRYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHR1</accession>
    <name>I4YHR1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956180.1">
        <property type="nucleotide sequence ID" value="XM_006956118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHR1"/>
    <dbReference type="STRING" id="671144.I4YHR1"/>
    <dbReference type="GeneID" id="18475215"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67167"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_1"/>
    <dbReference type="InParanoid" id="I4YHR1"/>
    <dbReference type="OMA" id="WFDDNES"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="89" mass="10197" checksum="D6DC5D97E3B509AF" modified="2012-09-05" version="1">MNDNSKIYISNLSWSTNDEDLARAFSPFGQISDYIVMKDRQTGRSRGFGFVTYANDREASSALESMNEVELDGRRIRVNYAHARSSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY2</accession>
    <name>I4YHY2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleoporin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_62244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956249.1">
        <property type="nucleotide sequence ID" value="XM_006956187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY2"/>
    <dbReference type="FunCoup" id="I4YHY2">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHY2"/>
    <dbReference type="GeneID" id="18474727"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62244"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008112_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHY2"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="11">
        <location>
            <begin position="14"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="10">
        <location>
            <begin position="564"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134136" checksum="B916106CCA9B1762" modified="2012-09-05" version="1">MTNIPPGATLARDDHVDLSVYASLPAQVSQALVNTDLYTDAVNSYIDSASGFAYVLTQRECFVWNYAKRALFSPTAYVFPCPSAIHSSGEANLGSSYTLPAAILTSPATSREPGLLLISPNGVYRFWEHVGMALSGVDKFIEGQLNDLSDGETVTGLFESDPSHYILTTSLTNLKHVVLAPSQGRLYPIIRPFPRTRGVFARLFSSGAYSTSEQFAALTLSQPDSFGSRDLFAIGERSVQVWSIGYASAAASSSNASKFVGQYHIRDAIADRIIPGSGFDIHKARLSVSMLDGAVTKDGKLAVLVSYITPNKETNDSDQLQSYALCLLVHTQDPTQPWSVEKIQELNYQAHLDPRPYSIPKLVVYEGGPAFFVVFSDAILISTLVESLKYSMLLPLQYPLNNKFIGFGITNDPTRALASPSNSQVLESTKASIYTFAVYGGIISTQLDLEKLEADIKKQIDPTTRLTSRLKSRLEQAIFYGDKQDNPISFAIPNGHVEGDLQEATKSVSKDILASRSTNMPVILDLRAQINDRAVRCYKLIQFISENGLLGKLAPSTRRQLCDDAEKLVAANELWLHENSEEAGTEGLLLASVEAYMSGSKEVNEDIVRLFFRTKVKDIGVLIDRMNALVIEYLESNPGIEKRSKTIIESNRYILATLSPSFKLRQQQSEIYGLDKSTRGFESWMAKSVMLNVLETTYDRTKKLLRDRSRELGSSIDDNPEDYQNAPNTKTTQKLLTRQSEQEELRQQLCSIAELTIESYEDRIEYLKASSKTEKELAVLLEKFNGNLRPSLIHPLVTIGKADFAFDLAENHRAFSILTELCTDVNVGSMERIKYYLDMYKEQFGFELYKWYVENGKLWTLFQHEQPYGDLLQAFFKQSDNGRFAWMHDLSAGKYIDASQTLIKESSKETELAPKHLILSLGKLSHIAQLDLDTFESTQAQQDIEATDDKLDLISIHGKLLELFGTQLSETGENIDMLDLEEKVAKITDVVASRLNLPNLINHFHNLIRGLYNGKALNAEDLVDLLTLKDNFLEQVTDYASAIDVCVRAKDVPDRRAHSSLKSIWRRVYLRDDWPMLNNTTGMNDNELGDNLRQSALYATIQLASENDHPEALFLSPKKSFNKLSEKDLSARFPSLPQDEVAAILSDLQEENARLESLIKNNNLDNWYKEVLRLHSEDHPKYQVAKDEQEQEMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI37</accession>
    <name>I4YI37_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_31122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956299.1">
        <property type="nucleotide sequence ID" value="XM_006956237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI37"/>
    <dbReference type="FunCoup" id="I4YI37">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI37"/>
    <dbReference type="GeneID" id="18471254"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31122"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="InParanoid" id="I4YI37"/>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="80"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="34634" checksum="15459F098FD3C312" modified="2012-09-05" version="1">MVMVNFVVKLPFTCSKKITDIKELKEWNFDGSSTNQAPGHDSDIYLRPAAFFRDPFRGGDNILVIAECYNSDGTPNKTNYRHYAKKAMDLVKDEDPWFGIEQEYTLFGADGAPYGWPKGGYPAPQGPYYCGVGAGKVFARDLVEAHYRACLYAGINISGINAEVMPSQWEFQVGPCAGIDMGDHLTLARFLLARIAEDWGISISLHPKPFTSGEWNGAGCHTNYSTSKTRAPGVGLQAIEEMIKKLESKHAEHIEAYGDDNELRLTGKHETGNIADFSSGVANRGCSIRIPRHVAHQGYGYFEDRRPASNIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI46</accession>
    <name>I4YI46_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956306.1">
        <property type="nucleotide sequence ID" value="XM_006956244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI46"/>
    <dbReference type="FunCoup" id="I4YI46">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI46"/>
    <dbReference type="GeneID" id="18475230"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67270"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086812_3_0_1"/>
    <dbReference type="InParanoid" id="I4YI46"/>
    <dbReference type="OMA" id="EFKDPMV"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="20329" checksum="0AAA71010ECC6547" modified="2012-09-05" version="1">MSLLKNRPLDIFYALYLIVHLPATLFIDMQSLYPEWLIPDALKNVLHFWISLTNDPILQGGSTDSPLWAWIRSFIALEAVGQVPVFILCSYGLYKGSKSVEIPLLVYGVSAATTTFACLATVLALPVHAPPLPPPLIGSLALTPEQRTILLAVYTPYIIVPIFIACDMAGRLSQRGNMNTKKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIC7</accession>
    <name>I4YIC7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956384.1">
        <property type="nucleotide sequence ID" value="XM_006956322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIC7"/>
    <dbReference type="STRING" id="671144.I4YIC7"/>
    <dbReference type="GeneID" id="18473309"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59359"/>
    <dbReference type="eggNOG" id="ENOG502S10Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026509_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIC7"/>
    <dbReference type="OMA" id="YSSTIWA"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697715" evidence="1">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="242"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="423" mass="47594" checksum="70362DB8F8C422EC" modified="2012-09-05" version="1">MKFNFALVISGLTFASALHVPISFSEEAGLQRQIVDTSRGWLSHYIYGESSESIDKATPLEVSENAWDVLKNDPKKFSKFTTILEKFSPSAVDHIKNEKDYTLFVPTNDAIPDHKEKDKGCASHDETDIPNYLGKLYAEARKSHTFDDEERKKHFSRFVEAVVMYHTVDQKLDVKTLHDFSTVETILTEPNTLNGAGQRLRIEQQFVPPATVINHFAKISTQDIKSSNAVIHALDHVLIPPPSAINALFIFAREFSIFTSALQKVGLAPLLDLSLDGKRGNGHLTINAPLNSAFEKLPPKVLGFLFSPLGTEHLKRLLEYHIVPENSIFIDFQSNKQAKSNENDDLFHKKVKAKTLLKDADPIEYELIKSQTVPYGPYSFDVKVQGKSVSWHDGIARNAAVQVLDELLIPPKEKNQWASIYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE3</accession>
    <name>I4YIE3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956400.1">
        <property type="nucleotide sequence ID" value="XM_006956338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE3"/>
    <dbReference type="FunCoup" id="I4YIE3">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIE3"/>
    <dbReference type="GeneID" id="18471267"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31227"/>
    <dbReference type="eggNOG" id="KOG3501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122140_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIE3"/>
    <dbReference type="OMA" id="REMIQQK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13788" checksum="12FAFCD798210CCA" modified="2012-09-05" version="1">MSVQNDEALQKVLISMQQQAVNAEKALRSVKLQLTSRTREKRLIELTRAELQTVPDDGRGGLYNGVGKMFMAVERPTLMDDLSKQERSISEDIVALEKKGKYMQKELESATANLKDVFQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YII4</accession>
    <name>I4YII4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956439.1">
        <property type="nucleotide sequence ID" value="XM_006956377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YII4"/>
    <dbReference type="STRING" id="671144.I4YII4"/>
    <dbReference type="GeneID" id="18473334"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59406"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_0_1"/>
    <dbReference type="InParanoid" id="I4YII4"/>
    <dbReference type="OMA" id="FLERYMQ"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="137"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="362" mass="40435" checksum="86D1C34B6EEA8D35" modified="2012-09-05" version="1">MSTSNQPLRFGVLGIGRMGIRHALNVVNEPRAQLVAVADPRKDVLEASKEILGENVKRFISEEDVINDPSIQAILVASDTTQHPILALKAIKAGKHLLLEKPIAVNLDDAAPVVAEAKRNPHLKILVGMSRRFDDSYREAFNRIQSGELGDVFHYYGVTNDQYNAEIVDFFVGYSKVSGSILVDCGIHDVDLMRWYMGPNEKVKKVYAAGYNARMHRLKESRDADNSVATIVFESGKLANIYLSRTAIHGHECWAQITGENGMIKVNTDNAMNRVTLADEHGYRKLTTQDYYDRFRGAFANEMREFTSAVLDNTPLPLNIDDAFEASKICVGLQMAFRSDEQIFFDKNGYPIPPKGIAPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ3</accession>
    <name>I4YIJ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_35431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956448.1">
        <property type="nucleotide sequence ID" value="XM_006956386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ3"/>
    <dbReference type="STRING" id="671144.I4YIJ3"/>
    <dbReference type="GeneID" id="18471913"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35431"/>
    <dbReference type="eggNOG" id="KOG2893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037132_4_0_1"/>
    <dbReference type="InParanoid" id="I4YIJ3"/>
    <dbReference type="OMA" id="QAHRHIM"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20218" checksum="64240BB85600B658" modified="2012-09-05" version="1">MGKKRRIENKPWCWYCEREFEDDKVLISHQKAKHFRCSLCPRRLNTANGLAVHVQQVHKLEADRIENALPGRSTFEIEIFGMEGVPAHDKAEYDRRRAEARGIDLNKKNQPAKRKRIFKGVISDADFYVQLQGHRHIMSGGRMPAPPGAVPTQNPQNAPPPGVLPPPVAPGVTPPVPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL4</accession>
    <name>I4YIL4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_59424</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006956407.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000445_50_4_1"/>
    <dbReference type="InParanoid" id="I4YIL4"/>
    <dbReference type="OMA" id="ERVYPIR"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="GAF"/>
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        <property type="entry name" value="GAF-like_dom_sf"/>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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        <property type="entry name" value="Phyto_chromo_attachment"/>
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    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
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    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="641"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1437"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1309"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1263"/>
            <end position="1272"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1315"/>
            <end position="1335"/>
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            <begin position="1341"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
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    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS50046"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    <sequence length="1604" mass="178859" checksum="D81FEA82EC954E67" modified="2012-09-05" version="1">MSEREQYVFPVRSVFNNGNPGLAEITGDIPDAQPGDKEERDGDISSHSRHTSSSIQLDTSDSDTSKVDKPTKSPTTYHANFDRRKGGSEKVSSSVGHDRPAPRGIDRNVHLNDPNQPLPEDEEIDTQPSSSDPSSADYGPTKQEEEKRELDYVQSKMELSEESASTDSESSNLSTRKQPSTAAEAMDLHKDKMNRIKDHNKSDLSLESLPFNSPEDESSISSLADEDEQLPTTRRFKYFEEEGNYFLRTHHQSKMKKCEDEPIGRPGAIQPFGAMIVLQNDDNGNSLVRQASENCPEIIGCSPEFLFSLTCFTTILDNDSRLKMRDVLFDLAVAEDSDSEGSSDEGEKEKAQFFGITGRGDDNVDDQYSESELSAESQHNNVWSCWCAVHKPDLPRPLNSHYPPPEEVFGKQGLFIIELEPVVSLKYPAYVDEVSKLPKEFDNRDARPAESLDLNLSNSDNTPKSGATHGSGSTTAALTSNSGADSKTGTNLSGDTVHAVPSAGGGTFHLETGQQQKQTQKETKQRIMTHEAEFSAHGNDSVSIEDIRRSTTAHNKPLKTLLRIRKADRAHETRQRVATLLEDNNKSDEDDEAANKRRKAHRRSQARAKIQRNMSMPGSLSSLDVVSLLGEINEQLSSADNIQELFDVTVGIVKSLTQFHRIMLYQFDPEYNGKVVAELVEWQRMKDLYYGLHFPASDIPPQARELYKTNKVRQLYNRDQLTARMVVRHKIDLAYPLNMSHCALRAMSPVHLKYLENMDVRASLSISIVAFGQLYGLVACHSGGENGMRVTFPMLQVLKLLSDSISRNVERLAYTRRLQSRKLISTVPSDTNPGGYIASTAFDLLSIFDADYGLLSIGDTMKIMGESDRSREIVAIGEFLRMKGFDQLVYTNNISKNFPELKQSDRKDALAGLLCIPLSNTGSDYICFLRKGQLSSVSWAGNPNKNDNEALRPRASFKKWTENVILSAKQWEDEQLETAGVLAVVYGKFIEIWRQRTEVSRSNQLSRILLSNASHEVRTPLNHIINYVELALEGTLDPETRENLVRSRDASKSLLFTINDLLDLTKVESGQEVLFNEPVNLKHLVVETVQEFHQEAEKRGLTVKVDIEKSSIHVISDHRKLRTIFTSLVSNAIKYNKENGSVGVTVTEMEQESDSRANIALVVQDDGIGIKKKKLEALFTGFERVEQQGTEGGSSDNSDVHLGLGLASCARAIEQLDGQLKCSSEPNKGTTFTVIIPFNLPDKQTMDSASNTESSDRSERSFRIRYKNRMPKKVNAGSESTNQSNISDELDHIGQQVKRMERNELDSFVEALAPSSRTNKTNSKNSKNSYGSGKSAAPNVDVNQQQSTTNGSNYASSKDSAGSSKKKYRKGRFQVQDSAYPIRAGPGQASSIPQSDIHSVSEDIDGLRINDTESVDSRNQSTAKTHSEYIADEKPPRIIYIDDDPINRNILKKKLTKNDRSIVELANNGDAGAQVVIEDEEGFDIVLMDLLMPIKDGYESCKAIRNAEKEGKIKSRIWHELNGRLPIFAVSASISPSHHGVLIESGFDAFFTKPINFDLLSNRLIASLIDKEKYSQSVYNEESRESFERGGFLRNIQTFNDNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP7</accession>
    <name>I4YIP7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955685.1">
        <property type="nucleotide sequence ID" value="XM_006955623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP7"/>
    <dbReference type="FunCoup" id="I4YIP7">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIP7"/>
    <dbReference type="GeneID" id="18474670"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61676"/>
    <dbReference type="eggNOG" id="KOG3499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIP7"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="85" mass="9616" checksum="754BB6449F1CD9F5" modified="2012-09-05" version="1">MPQEIKDIKNFLEIARRKDARSARIKKTKTIGAKGESAQLTKFKIRCSRYLYTLVVSDAEKAEKLKQSLPPTLNVEEIGKAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP8</accession>
    <name>I4YIP8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_55794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955686.1">
        <property type="nucleotide sequence ID" value="XM_006955624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP8"/>
    <dbReference type="STRING" id="671144.I4YIP8"/>
    <dbReference type="GeneID" id="18472741"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55794"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1866694_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIP8"/>
    <dbReference type="OMA" id="STITMFT"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="137" mass="15240" checksum="3009F75E37C6D614" modified="2012-09-05" version="1">MHRTIARLASTKAQVLPPPTIPHFEQKVQLSDGSTISMFTTSPRSVIKSSKDTGNHAVWNPQSVKLTTEDESGRLTRFAKRFGLQADQGPEKGRLERQMAMGGFGDSDLQSITREATDMEKKVQAKPDYKPSPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIV3</accession>
    <name>I4YIV3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reduct</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_66783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955737.1">
        <property type="nucleotide sequence ID" value="XM_006955675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIV3"/>
    <dbReference type="FunCoup" id="I4YIV3">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIV3"/>
    <dbReference type="GeneID" id="18475150"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66783"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_2_1"/>
    <dbReference type="InParanoid" id="I4YIV3"/>
    <dbReference type="OMA" id="AWKEEFY"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="307"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="600" mass="68748" checksum="F431DCAE8DA2F938" modified="2012-09-05" version="1">MKITEKLLAAEREDRLWWSFEFFPPRTAQGMTNLVDRIERMRRLGPEFVDITWHSGGRTAELTTELVKTCQASIGVETCMHLTCTGMPREKVINALEEAKKNGCTNVLALRGDPPRGQTEWYPHPNGFTYAADLVRHIRQEYGDYFEVAVAGFPEGNLQYKHSSDKDNEIQYLKEKVDAGADLIMTQMFYDVDNFIDWCNKVREAGVTVPIVPGIMPIQTWNGFQKAVQMAQTKVPQDWMDQLEAVKEDDAKVREVGTKLVSDMCRKILDANVGIRGLHLYTMNLERGPKMILQELNLIPQTQILNPLPWRPSLTPTRRAENIRPIFWANRQKSYLSRTEMWDEFPNGRWGDSRSPAYGEIDGWGPTINFKLDEAREIWGEPLKYDDVCNLFSRFCLNDLKALPWSDQPPARETSVIDRQLAMMNKIGFFTINSQPAVNGARSDDPVHGWGPKGGYVYQKAYLEFFVSPDNLDKLISRIELNPMMTYYAVNRRGDLRTNTHSEGPNAVTWGVFPGKEIVQPTIVEAVSFMAWKDEAFELGYQWSDIYEKGSTSQQLIKDIMDSHFLVNVVHNDFKNGQDIFKPFLDEIANESAIKDTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ00</accession>
    <name>I4YJ00_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_59020</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955781.1">
        <property type="nucleotide sequence ID" value="XM_006955719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ00"/>
    <dbReference type="FunCoup" id="I4YJ00">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ00"/>
    <dbReference type="GeneID" id="18473130"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59020"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="InParanoid" id="I4YJ00"/>
    <dbReference type="OMA" id="LCDADNI"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="46"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="577"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM23942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="719" mass="77812" checksum="7DC30075A2704710" modified="2012-09-05" version="1">MIGRVLPNFRITRRAFSTTVFRPSQTLVEKIVSNYTVGTSPGYKVRSGDYVMIKPEHIMTHDNTGPVISKFKTIGAKSPANPRQPVFTIDHDVQNKSEKNLEKYSKMEAFAKQHNIDFYPAGRGIGHQILIEEGYAWPQSLVVASDSHSNMYGGVGCLGTPIVRTDAAAIWATERTWWQVPPVVKVELKGKLSPGVTGKDVIVALCGNFNKDEVLNSVIEFVGDGVNLLSIDERLAIANMTTEWGALAGVFPVDDKTITWYESQAKKLELGAFSNFAPSAGHTPGQEHPRINAKRIEHLKENNLKADSDASYAAHLILNLETLVPHVSGPNSVKVSTPLPQLTERKVKIDKAYLVSCTNSRASDIKAAADIVRNKKIADGVEFYIAAASAVVQSDSEQSGDWQTLVNAGAKTLPAGCGPCIGLGTGLLEDGQVGISATNRNYKGRMGSPNALAYLASPAVVAASAVKGYISGPNEIENLHLSTSNKPEYSIEKKEAESTSEKPIIKEDLLPGFPASFEGPLIFAPQDNLTTDGMYPGKYTYQDDITPEKQADVVMENYDPSFAKIIKKLHEKNDKVDTEDNKNGVILASGFNFGTGSSREQAATAIKNAGIPLVLGGSFGDVYRRNAINNGLIVIECPELIKDLTKEYTPTNERGKGGLNGEQTIHSGKNVRISTSDGKIDIINSEGNIIKTYIAARVGTAVQDIWIAGGLEGWVKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ78</accession>
    <name>I4YJ78_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_34554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955853.1">
        <property type="nucleotide sequence ID" value="XM_006955791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ78"/>
    <dbReference type="FunCoup" id="I4YJ78">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ78"/>
    <dbReference type="GeneID" id="18471871"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34554"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_0_1"/>
    <dbReference type="InParanoid" id="I4YJ78"/>
    <dbReference type="OMA" id="PEYYVPR"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="212"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="564" mass="63112" checksum="77E3029EA14021A5" modified="2012-09-05" version="1">MITKYTKILNSLQRIYLSSSSPSHSIESISQLQAYARSLGSDDAVNQKTSEYEQNLRNATAEEVVEPSTSANTVDVEPINLVEKTDEVTPPIEELDKGAIYQPIEPIHIPDSQSSQSSQLIHTPRYTKVPSSRIGRLFHYGGLAAGLTYGTATEYLKGNDRQGQSLFLSEGNVDRLVNKLSTMRGAALKLGQFLSIQDSHLLPPQIETALSRLQNRADYMPNWQLEAVLSKEFGPNWMDNFEEFNKVPIAAASIGQVHSATLSANHPKHPLMKVALKIQFPGVKESINSDLNNLKILVSASGILPRGLYLDSTIKVMRAELADECDYLREAECGEQFALNLENDPEFKCPVVVKDLCTSNILTTEFMSGEPLSRAYEYDQSTKDKIGSAVMRLCIREIFEFKLMQTDPNWSNFLWDKESGKVGINLIDFGASRPYTEDFVDAFGRLLLSAGNGDREECVNSSLRLRYLTGEENDIMINAHIASMLALGEPFRQPTAYSFKNQTITDRVKEQIPTMLKHRLTPPPKETYSLNRKLSGAFLLCSRLGSTVSCRDIWEEVTKGRYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE0</accession>
    <name>I4YJE0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955908.1">
        <property type="nucleotide sequence ID" value="XM_006955846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJE0"/>
    <dbReference type="GeneID" id="18475184"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66942"/>
    <dbReference type="HOGENOM" id="CLU_2374374_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJE0"/>
    <dbReference type="OrthoDB" id="10515171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="9887" checksum="9B180626C928AA4F" modified="2012-09-05" version="1">MAQNFRTDTTDEGGYGVNAYGNAFSRSNQAGLDGTGGTLSANSGIHSKPEDGTPQSTSSTELSGLAKEDTHNSSYPGAAHTLSSQGTVDTESSNTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJG1</accession>
    <name>I4YJG1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955929.1">
        <property type="nucleotide sequence ID" value="XM_006955867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJG1"/>
    <dbReference type="GeneID" id="18473169"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59092"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJG1"/>
    <dbReference type="OMA" id="HIVGETC"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="483" mass="53893" checksum="1F36CF30D426945A" modified="2012-09-05" version="1">MDSSTLNSSDEKNIGLYNQNEDAIRKRLLRRVDWNVVGILVFIYAVNFLDRVAVGQAKLEGMLEDINVSDKQFQIALTVFYISYMVSEIPWNMLTKRIGPQRTIPLMALTWSVVCTLTGIVKNYPGLLAVRWFLGLGEGGIFPGMIFFLSAWYPRKKLAFRISTVYNASQFAGAFGGIFSYALAQLDGVGGLRGWRWIIIIEGLLSFIIAFTSIFCIQDFPQKSKLLNEDEKGVWFRYIEEQQGVAESKNVPFTMGQVTSVLKDRRTYMFSAINYCNGSLFYALATWIPTIIKSLGDFDAAQSHLLTAPVYVCGIIVTFTAAWLSDHFQQRGILCIIGFVVSGIGFIIILSVQAVSGKFFSLFLMVSGTNICNAGLLSWFGATYAPLYKRAFAVGFIVMLGNCGGLVSSFIYPESTAPRFIPGHAYCLALALTGLIVASILRWTIKRENKRRDKVGDKDILMGMSDLDIALLGDKHPQFRYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJS8</accession>
    <name>I4YJS8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_30924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956038.1">
        <property type="nucleotide sequence ID" value="XM_006955976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJS8"/>
    <dbReference type="FunCoup" id="I4YJS8">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJS8"/>
    <dbReference type="GeneID" id="18471211"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30924"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_2_1"/>
    <dbReference type="InParanoid" id="I4YJS8"/>
    <dbReference type="OMA" id="VFRATQT"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="494" mass="55217" checksum="04D91DACA25CB8DE" modified="2012-09-05" version="1">MSSSSNSSIVAVHYRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKSDAPQLRDEYRSYKILANSPGIPQVYYFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSIKTVVMTAKQMITRVQAIHERNLIYRDIKPDNFLIGRPNTKNGATVHVIDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQLTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYDFLRDLFTKVLKNSGQVEDGVYDWMLINNGKGWEVGNSSSHRDHHHRHRERERERADYRRSQAAAAAAAAGANGQSGANGVLPPSPALVRHGSKRGRTNNGNLNASSQMLAPTSPTNAQSPPANSRRQSQQNQLNTAHPYASTTGAIMSPSDLGDRNAATPSPARDLNNRNKGYMNQDSNQGISNQNVDQNGEINQSNNQDRQKNGGASKKLVDFLTCRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK24</accession>
    <name>I4YK24_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_14295</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955667.1">
        <property type="nucleotide sequence ID" value="XM_006955605.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YK24">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YK24"/>
    <dbReference type="GeneID" id="18470631"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14295"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_1_1_1"/>
    <dbReference type="InParanoid" id="I4YK24"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="469"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="715"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1086"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1184"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1219"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM24316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1322" mass="151958" checksum="EB3BFE9605B236DE" modified="2012-09-05" version="1">MPPPKAKKSTSNKRKSAQSDDDDDIDVPEPKSSSSKQKSASETYQKLSQLEHVLKRPDMYIGSCMSHEDKHWVFDEETKALVEKDISIVPGLYKIMDEILVNAADNKTRDPRMDLLKVEIDRESNKIHIHNNGKGIPVEIHSKEKIYIPELIFGSLLTSSNYDDDDKKLTGGRNGFGAKLTNIYSTEFTVETADSEGGKKFKQTFRNNMGDRETPKITSNSRGEEYTKITFKPDLARFGMDKISDDMYALMTKRVYDMAGCLPGVKVYLNGTRLPIRNFKQYVEMYVTSTIDNEGESSTKKPTIIHERVNDRWEVAFALSDGVFREVSFVNSIATTKGGTHVDHVTNQITTKLGEIIKKKNKGANVTAGKMKNQMWVFVNSMIENPAFDSQTKETLTLKATQFGSKCPLSEDFHKKVSKSGIVDNILDWAKFDADRQMAKGDTKTKKSKVSIKDYEEANKAGSREGHKCTLILTEGLSAKTLAMSGSQVVGRDYYGVFPLRGKLLNVRDASHTSIMNNAEITSIKTIIGLAHKKEYKSITELRYGSIMIMTDQDHDGSHIKGLLINYFDHFYPSLLKIPGFLVEFITPIIKLFKRNKEVSFFTIPEFEHWKAENDEGRGWRLKYYKGLGTSSDEEARQYFKALDRHRIPFSATQEGDRELIDMAFNKKRTEDRKEWLRGYNPRTFLDQDIEELSYKDFINKELILFSMADNARSIPSMVDGFKPGQRKILYGTIKRNLKNEIKVAQLGMSVAENTAYHHGETILFQTIVGMAQNFVGSNNLNILSPNGQFGSRREGGKDAAAARYIFTAIPRITRTIFHPDDDPILTYLKEDDEWIEPEWYVPIIPMVLVNGADGIGTGWSTTIPNYNPSDLVANIRRKLNNQDIQPMIPWYRGFTGNIERVSNDRFKNQGIIEQIDDDKVRITELPVRVWTVPYKEEKLKLWVQGSDKQQPLIKDYEEHDTTTTVEFIVTLEKNQMKTALSKGLHEYFKLNSSIATSNIVCFNSDGKIKKYTAPEEILEEFFYIRLKYYQLRKDYQMHELGIAFDRISNQARFIKMIIDRELIISNRKRKDIVDELRAKKFTPYPKQKEKKRPGEVEIIGQDEEEEENVGGAGDYDYLLSMQISSLTMERMEQLLKQRDSKEEELNNLAKLQPQDLWNVDLDKFMEEWEALLEKDIEDAKKVEKGSKNKGATAKRVQKAMKKKRGDDDDDDDDFSAAPKRKKASPVKKKTQPKKEEKDNIDDIEVTSKTTKKAPAKKHKIESDEWVCMYFCRSTLMKTPVIHHQRSVRLPRRLRILKAPKRSQLRNQLKLQLRKPLQRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5D3</accession>
    <name>I4Y5D3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960796.1">
        <property type="nucleotide sequence ID" value="XM_006960734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5D3"/>
    <dbReference type="STRING" id="671144.I4Y5D3"/>
    <dbReference type="GeneID" id="18474637"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61610"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474253_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5D3"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="492" mass="56453" checksum="C77F5C0A5175E099" modified="2012-09-05" version="1">MDQDVDLNSDNAPIEPDEEQKPKEEHEEEEEEEEEEEEGEGGSGETRCVCGSTDEESYGFMIQCETCGCWQHGVCVGLVDEKYAPDTYYCEQCRPELHPIVLPNRPGRKPSRHNQQKKELKQKSPVSSSRRRSSSSNDAQERVRSPKRRSTLNSRDAAYDDAIAASLLSVQNDNLRAQIAEREKQRWVQYGGQVTPSQNDDENGNIEQIEEQTVAEDHDGDKVPENEREREREHEHEQEREPSREKHIDGEADYKPRSRSDPRAAAPRGRGGKRKDNGRNSAAVKARNKEKSVVNDDEEKTDSNRRSGSPNSAPADERERAPSRGYKKRRRETDESNNEESGFTPPTTANGPRRAATSSRKDKNLQSPHKRKTVAREKDKKNSYDDESSLTWGLPDHLQHLSHMLPSETPEMLALRIPHGDTIDIVREMPTRVKFPTKRMPIGEMKRRVRSVLEYTESPAESIQMLDNITRELIRFNERFSTNAKRREEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5E0</accession>
    <name>I4Y5E0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_22924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960754.1">
        <property type="nucleotide sequence ID" value="XM_006960692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5E0"/>
    <dbReference type="GeneID" id="18470938"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22924"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_1_1"/>
    <dbReference type="InParanoid" id="I4Y5E0"/>
    <dbReference type="OMA" id="FASWSWV"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="456" mass="49803" checksum="E33208CA0E3E3D2C" modified="2012-09-05" version="1">MLDKSSRELNNEESSEVIHIKPNWKNWLNLVIFSLAQYIDVFGTYATIIAIPIIGEELSLDSATSSWVIDGYLLVFASFLLVFGKLSDLYSPKLVFVIGLAWMGILHLGAGFCKNAVALVILKALSGWGAAATIPSGIKLIVMEFPDEEYRRIALSIFCLCGGIANVTGTIFGGLLTSVDWQWVLWIISIITIPLSLASFFTIPDVPLKFETDSKMDFVSSFIMVAGLVLLIYSLTAGNTVGWPTAHILVPLILAVLLLVAFFYLQTRMSPRRALIPPRVWRYKGMTVLFCASLTVSGWWTCVLISLANIYQDVWHWDPTKAAVHFLPFGIASAISGSLASTILKYANFKLSILVAYLASLSGVLLISFGDEQSLYWRFAVPGMVIGSAACAFLYTATNVGMVQVSPDNETGLAGSMFQMSQQTGSAIMISIFIAIRGAVNEQSTDIFKGTSAGMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5N1</accession>
    <name>I4Y5N1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Cla4p</name>
        <name evidence="15" type="ORF">WALSEDRAFT_52899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960667.1">
        <property type="nucleotide sequence ID" value="XM_006960605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5N1"/>
    <dbReference type="FunCoup" id="I4Y5N1">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5N1"/>
    <dbReference type="GeneID" id="18472597"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52899"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="InParanoid" id="I4Y5N1"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="299"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="570" mass="63105" checksum="3D450D73531A3ECF" modified="2012-09-05" version="1">MSWLWTKKWIVLNPRTIDIYKNDSAPAPQMAIQLNKIIAVERTDQKPFCVEITTNKVYSLAFKSDDELYAWLDDIYNASPLGVTTPTDFVHQVHVGFDPVSGAFTGLPEQWNKLLQTSAITKEDYAKNPQAVLDVLEFYTDQQRREEVGYSQGQKAGQTNRFPPSGGTTYTPPAANARFGNGTGLAGQNAAAPRAAPPPPAQPVKKEKAPATTTQPAPQATQKAPPPVKPLLTNKKANTPNLTPAQQQAQAKQPQPPSPSNEEPPTPKVAERRISAMNDTQIMEKLRQVVSQGDPNNIYSKIKKVGQGASGSVYVAKILENGQKVAVKQMDLSAQPRKELIVNEILVMQESHHANIVNFLNAFLIKNGELWVVMEYMEGGALTDIIDNNEIEEDQIACICRETCKGLNHLHQQSIIHRDIKSDNVLLDSQGHVKITDFGFCAKLSDQKSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIEQEPPYLDEEPLKALYLIATNGTPTLKKPESLSRELKSFLAVCLCVDVKSRAAADELINHEFMQKSCALSGLAPLLRFRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5N8</accession>
    <name>I4Y5N8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_49257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960674.1">
        <property type="nucleotide sequence ID" value="XM_006960612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5N8"/>
    <dbReference type="FunCoup" id="I4Y5N8">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5N8"/>
    <dbReference type="GeneID" id="18472493"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49257"/>
    <dbReference type="HOGENOM" id="CLU_150144_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5N8"/>
    <dbReference type="OMA" id="YTLWIIV"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="68" mass="7981" checksum="33BCB3F25C2F974A" modified="2012-09-05" version="1">MLASVTIFSYYTIWVFVTVIIQPIYELKYFPDRKWAIRIPIGLLLMGLSIVGIFTSSVLIKEKNRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X3</accession>
    <name>I4Y5X3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_34133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960641.1">
        <property type="nucleotide sequence ID" value="XM_006960579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X3"/>
    <dbReference type="STRING" id="671144.I4Y5X3"/>
    <dbReference type="GeneID" id="18471819"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34133"/>
    <dbReference type="eggNOG" id="KOG4227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030900_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5X3"/>
    <dbReference type="OMA" id="SNIFCLC"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="577" mass="64679" checksum="3924F830ACA84BDE" modified="2012-09-05" version="1">MRLPYRNSDFYKNGLPYSNSFKAHTGCVNAVTFSKTNGNRIMASGGDCTTVYLWDLFRDFDGATPIHAFSGPTKNIFTLEFNCQDDTLYCGSNDAVIYKYDLQSQTKDVFGMKSPVYKDKLEDLPTSPPDVRQTSHASSISQISAHPIHSSLILSASSDDELHITDERVSNYDNVGHFHTTAEWRDVKWHPVSEHLFGCCDSRGGVYLNDIRKGFTGYNITSGSFSESVDPFVDDMSVMQYNAQLTNTHASKRVKLDSSSISFNNTGDLFGVIYQHSFPTIYSLNKSDPLAVLTGDYLPYGARVSPGERTYSTSCTTKHCSFEGDYFATGSDDFRGYVWKIPPISRLLEGRREVSNESLLEGFENGSFGQYRSVFSKSKDEDVCIPTIVNRPAFRLEGHASIVNSAMIHPTLPLVATSGVEKIIKMHTPTPFTNNLEAKETPKSRKMGNETRSSRRDFLMALLTSPYENEEGTVEEDPLTLNFFDSLLRRDQEVDIWNEPDSNDEEDEEVDEHDDIDEDDVADVMMRFARDNSFGDGHEDETDDDDSDGPIVITNNEDEISSDGSEESIDIDEAYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y614</accession>
    <name>I4Y614_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960556.1">
        <property type="nucleotide sequence ID" value="XM_006960494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y614"/>
    <dbReference type="STRING" id="671144.I4Y614"/>
    <dbReference type="GeneID" id="18474559"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61483"/>
    <dbReference type="eggNOG" id="KOG4137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071116_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y614"/>
    <dbReference type="OMA" id="HSKHYCD"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="169" mass="19620" checksum="B04F8F1E9584F52F" modified="2012-09-05" version="1">MPPKKKARQSSVSDSSTPQPPDKVVDYYNYYDTARPFKNPKWSNTKRNKIYKQVMAIEREREKQQLDSIKLDKQKLADIKAGELEASEEEIKELENLPDSLTNFFTIECPPSLLPPAKYCDVTGLRANYTDPRTRLRYNSIQVYDVIKTLQPSSQQQFLSIRKSETVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6B4</accession>
    <name>I4Y6B4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF962-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_41189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960431.1">
        <property type="nucleotide sequence ID" value="XM_006960369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6B4"/>
    <dbReference type="FunCoup" id="I4Y6B4">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="GeneID" id="18472206"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41189"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6B4"/>
    <dbReference type="OMA" id="ETHFAFY"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="18010" checksum="1AF57DB7E3492AF5" modified="2012-09-05" version="1">MKVFDLESQLHFYFRYHKNTTNVNIHRICVPLILWSTFAILAKLSTTYAIILAAIYQTYYFILSISIGFTYLPIMTLMLLSRNYITSVYTLIFIHIISWIAQFYGHAKHEKRAPALLDNVAGAVFLAPLFVHIENLFSLGYYNNLQRNLHNRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6M7</accession>
    <name>I4Y6M7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960282.1">
        <property type="nucleotide sequence ID" value="XM_006960220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6M7"/>
    <dbReference type="FunCoup" id="I4Y6M7">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6M7"/>
    <dbReference type="GeneID" id="18475738"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70433"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_45_3_1"/>
    <dbReference type="InParanoid" id="I4Y6M7"/>
    <dbReference type="OMA" id="VRYYMRL"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="146"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="370" mass="41826" checksum="71459888969BE707" modified="2012-09-05" version="1">MGDTERASEIVQKVTFDLDLFNLLDKPLIALSNGQSRRLKVAEALINQKHLLILEEPFTGLDPPSRLKLSEVLKRLHSHSNPVVLLLLKNSDEIPESTTNILQITDDNYIELGRKDKVLSTITSNNKFSTPSDVGLGKVNQDKILIDLKDINISYRSTPILRNINWTIKPGERWHLQGYNGSGKTTLLSLITGDHPHSFTQNITLFNSPRVKIPTVHLSTLIGSISPEITSAFPKHTTLTAFDVVASGFSGIFCYRPTKLQHEKDRVHHLLKHLTPGLDSNTPFISLTTSQKSCILLARALVNKPPLLLLDEPFQGMSTEDLHRSRHYLQFNLDDEQSVVFITHYDNEVPWRIDQSRYLRLKDGKIDSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Q4</accession>
    <name>I4Y6Q4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960309.1">
        <property type="nucleotide sequence ID" value="XM_006960247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Q4"/>
    <dbReference type="STRING" id="671144.I4Y6Q4"/>
    <dbReference type="GeneID" id="18474490"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61373"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y6Q4"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="10">
        <location>
            <begin position="54"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="448" mass="50843" checksum="B63485A29C0A8CF5" modified="2012-09-05" version="1">MEKLSRRSINLAISSRALTTIKAIDGENGNLYHNLVTNATIPMKGRMIHITDGSLDSQLYSNKGECIYAIDRQKLNNALISEAESIPNVSFKFKSKIRAVNFDERELSYETTEGLQSDNRWDFMIGADGAHSVVRNQLMRVIRMNYAQEYIPHAYLELSIPPGPIDPETGEPSFLLDPNHLHIWPRQSFMLIALPNQDHSFTCTLFAPFEKFTELADNKDNFIQFFRQDFPDALKLMGEESAAEDYINNPKGSLVTIKCSPYHYKDRAVVLGDAAHSMVPFYGQGMNAGFEDVRVLLSLMDSEGVSSSKKVKHESLLNSLNRYSEERERDLKSIVNLAMGNYVEMRSKVINPIYLLRKQIDGVLNKVFRPPSVPSANILARTTFPTAANSGWMSLYELVTFRPDISYADAEEITKKRDKKLKNYTILTAFTVATISTIKIYKLLRDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T6</accession>
    <name>I4Y6T6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960339.1">
        <property type="nucleotide sequence ID" value="XM_006960277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T6"/>
    <dbReference type="STRING" id="671144.I4Y6T6"/>
    <dbReference type="GeneID" id="18473045"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58644"/>
    <dbReference type="HOGENOM" id="CLU_880561_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T6"/>
    <dbReference type="OMA" id="LMSAENC"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31913" checksum="873E8F192464FB1D" modified="2012-09-05" version="1">MSHLYSKPEVSYVRDGLLTSPVERLDGRQSEDFRSIEFERGNLLNSSGSCLVRTKGCEWQTSIKLEIAEGAEVSCIDTQVDFTSSTLNTSRIPENMSAGMLSNLLRNTITLPIEQFRIIDADEKSKWFRLSISSTLATIDDSSYSNIIDTLYLSVFISLLDVRLPHTQPLNYEENQTDSLKIGKQQSKKGIDFELIDSHKGGFSLEGLNDIPLSITINVIKGVHFIDATSLEDSIDDLISVTLMFNQQGQIKGTQLNGKGELEYSQLNGVIQHGSRLIKDLFKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y707</accession>
    <name>I4Y707_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_30189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960257.1">
        <property type="nucleotide sequence ID" value="XM_006960195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y707"/>
    <dbReference type="FunCoup" id="I4Y707">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y707"/>
    <dbReference type="GeneID" id="18471133"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30189"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y707"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="136" mass="15930" checksum="BC90DBCABC3607B3" modified="2012-09-05" version="1">MPKIFKSGKVCVVLSGRYAGKKVVVIKQFDEGTKERPYGHCLVAGVERYPLKVHKQMGAKLIQRRSKVKPFIKSINYNHLMPTRYALELEGLKGIISQETFKEPTQREDAKKQIKKLFEERYQSGKNRWFFHALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y784</accession>
    <name>I4Y784_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor eIF4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960160.1">
        <property type="nucleotide sequence ID" value="XM_006960098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y784"/>
    <dbReference type="STRING" id="671144.I4Y784"/>
    <dbReference type="GeneID" id="18471128"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30114"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_3_3_1"/>
    <dbReference type="InParanoid" id="I4Y784"/>
    <dbReference type="OMA" id="KTHNDSM"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="19865" checksum="9977D2218665EA25" modified="2012-09-05" version="1">MTLALRTPWTVWGIHRPPSSKIVDYEKDLIKVASFDSVESFWNTYSYLNPPSTLPVVTDYQLFRSGVRPVWEDPENIKGGKWILRLKKGIVDQLWEDLVLAIIGGSIAGGTDDICGAVVSIRAAEDIISVWIKREDPLLIDSVKEEIYKALNQTPANLEMQYKSNSGQSSPRRFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7X3</accession>
    <name>I4Y7X3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_52314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959786.1">
        <property type="nucleotide sequence ID" value="XM_006959724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7X3"/>
    <dbReference type="STRING" id="671144.I4Y7X3"/>
    <dbReference type="GeneID" id="18472580"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52314"/>
    <dbReference type="eggNOG" id="ENOG502RZAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7X3"/>
    <dbReference type="OMA" id="IVYTGEM"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697801" evidence="5">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="468" mass="50406" checksum="290CF46D478BDF5E" modified="2012-09-05" version="1">MILKSLSFAAAASHVAFAASVTIDPNLAGCKALEKIGKTQVHYPIDEVVDIINVISEQNVPFALKSGGHAQNVGFSSTEGIQIALKNFNSVEYDPVTNLATIGTGQLWESVYAGLEPHGVSVNGGRVSGVGVGGFVLGGGYSWLTNQIGLTSDRVVEYEIVLYTGEILKVNREYHPDLFFGLKGGGNNFGIVTKVTLEAHQQGQVYGGQIFISKDSLSKANTAISNWDKNKNDPKSSIGVTYGYAPGQGLFAELLLFYDGPTPPKGVFDEILAIPSAKSSVFSRSYTDLVLSVNGSATDGVRGYYRGISLKEYPVVLLESIANYTETLGKEAESHSLASLVVAVEPFLKNINSHDTYGPSAFPHPADGYLSPANFIPTWTDEKEDSYFYDLTKKFSDAITFNADALGQNISHAIIYNNYANADVPHERIYGDNIDKIADIKKRYGVDRVSHLTGGFIVGKSVGKSGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Y7</accession>
    <name>I4Y7Y7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959800.1">
        <property type="nucleotide sequence ID" value="XM_006959738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Y7"/>
    <dbReference type="GeneID" id="18475680"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70057"/>
    <dbReference type="HOGENOM" id="CLU_1679319_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Y7"/>
    <dbReference type="OMA" id="DSSFRCN"/>
    <dbReference type="OrthoDB" id="3360355at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="19534" checksum="FC7523B9E2E6AC6D" modified="2012-09-05" version="1">MYQSTYIRHKVFINYFNGSSFPFYYLTMIFDSRDLDYDISKDYETSNNSSSYNARSGLGLGLSFTFEHNQQNNTSTTNTPNVSPMKLKGVLRSPPPLSFNQSPKLTRKRSVSFGKEHVQAYDKRAPPDHVITNANAGSKIAYKSKTIQTSPNVHATPVSAKELTTRLNAMYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y840</accession>
    <name>I4Y840_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein transport protein SEC24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959853.1">
        <property type="nucleotide sequence ID" value="XM_006959791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y840"/>
    <dbReference type="FunCoup" id="I4Y840">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y840"/>
    <dbReference type="GeneID" id="18474354"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61139"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y840"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="874" mass="97301" checksum="7C416AA1F8825492" modified="2012-09-05" version="1">MSNNLPPGWSAHIDPSTGQEYYVNSLTQQSQWELPTVQNTQKQRRHLTHQQAQKYYSSQPADVPQQPTQLFTPGIGQQQPMQAQQPIQNLTNDFQQFSLSHPQQQRQSANSINLIGQVPDPNALENDPPMISLPPNATFSQSPTANAHHSFKRSTLNVIPTTQSLLNKFKIPLSLVITPYRSVSSTEEQIPVISDSVISRCRRCRTYINPYVTFLEGGTRWKCSICNLSNEVPQMFDWDPITNQPADRFKRAELNHSVVEFVAPSEYMVRPPQPPVYAFLIDVSYTSVQSGMVATVARTILETLDRIPNEDGRTKVCLIAVDHALHFFNLPPGSTDPNMLVVGDLDDPFLPTPNDLLVNLSEARGAIENLLTNLSDMFQTASGPESAMGTALKAAVQLISPFGGKIMVMTGQLPNVGQGALKNREDLKILGTPKESTLLQAAGGGFYKNLAIDCSRSQISVDMFLFGHPYQDVATLQCLPKYTSGQTYFYPGFNASRTEDALKLAHELSTVLSSPIALEAVMRVRATRGVRMSEYHGNFFVRSTDLLAMPTVPIDQSYCCEITIEENLNVPFVVFQTAVLHTTCYGERRIRVITLSLPTSSNPSEIYASADEQAIATLLANKAVERSQSAKLEDARDAVVNKLVDILGQYKSIMTSGGGASAQLMIPENLKNLPLLMLGLLKNVGIRQSSHIPSDLRAYAQCLLTTLPTQSLIPYLYPTLYSLHNMPMEAGTINEQGLVMPPKLNLTIEKFERHGLYLIEDGQHIFLWIGRDAVPQLVLDVFNLPSLQDLRPGKMTLPVLENPMSERLNAIVNKVRESRRGPYRPHLYLVREDGDPSLRSWALSLLVEDRFEMGLSYTQWLSTLRDKINTGSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8B9</accession>
    <name>I4Y8B9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_33458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959699.1">
        <property type="nucleotide sequence ID" value="XM_006959637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8B9"/>
    <dbReference type="STRING" id="671144.I4Y8B9"/>
    <dbReference type="GeneID" id="18471685"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33458"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y8B9"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="119"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="264"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="349" mass="37366" checksum="5BB1CD450966E1E3" modified="2012-09-05" version="1">MEETRKRSRSRSPTPERSSYERPSYKRPHIVKDDNPYLTVRSLIDTRDASIIIGKGGQNIAKIRETSGIKLVVSGSIPNNPERLLTATGQLDAVSKAFGLVVRTINDEDFNQPSLPGSKAVTLKFAIPNMKMGFIIGRAGAKIKEIQEASGAKISTSDYVLPNSTERVLSIDGVADAVHIAIYHVGMILADQTAVPSKERGDRRRVQNQSYGDTSSYGSPAPYAAAPPVYGMLPTYASTVPGPAPAQLGGAPPFGGYPTLPVAETTSQKIYVPNNLVGGLIGKGGSKINQIRYTSQCSIKILEPGEGEQTEGPSIERLVLISGPASGIQIAINMLSEVSNNLKYERVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I9</accession>
    <name>I4Y8I9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_20918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959769.1">
        <property type="nucleotide sequence ID" value="XM_006959707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I9"/>
    <dbReference type="FunCoup" id="I4Y8I9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8I9"/>
    <dbReference type="GeneID" id="18470862"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20918"/>
    <dbReference type="eggNOG" id="ENOG502QSA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_935572_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8I9"/>
    <dbReference type="OMA" id="VTWVYEM"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="32776" checksum="C6C452475345CF8E" modified="2012-09-05" version="1" fragment="single">RPSYLIPLQVDGGVWRMMRALTKSSEGFFALWKGTLTSCIFDIAFSTLQPLALSSLSAIFLPSNTLSFLPIHQLPHPFKPLSVHVLAHTLTSIALSPLDLVRTRMIVQATSTTSSNVSRRAYSGPIDALRKISSQEGGWQSMWTHPNLLFPTIVESSLKSLLQLCGPLIIERLLGVSIDSRPATYAICELLWSIGSMTLSLPLETVRRRLQIQDRSLVKMPQAGKFTPCVETRPIPSAGIVETIYRIVTEETSESTDSRWAGFKSLFRGFTMGTSASSLVFILGMFGGVDAAEGWTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y913</accession>
    <name>I4Y913_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959481.1">
        <property type="nucleotide sequence ID" value="XM_006959419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y913"/>
    <dbReference type="STRING" id="671144.I4Y913"/>
    <dbReference type="GeneID" id="18471651"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33288"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556473_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y913"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19085" checksum="39E1B28D71127EBD" modified="2012-09-05" version="1">MPGTPMIDMDVDSAPFKAIPRSFSAGTSCVQPNMLHNAAMRQQQQLQHSRTIPVSMSTPLTGLHTQYQQQQQRKQPIAPLQPQPPRSTASTYTAMATGLSSHVTSQENANIPANPSSAAAPFAKDEKDRDKPFKCPVPGCNKAYKQQNGLKYHRMKGQCSFKQQEQEEQIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y986</accession>
    <name>I4Y986_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_29467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959325.1">
        <property type="nucleotide sequence ID" value="XM_006959263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y986"/>
    <dbReference type="STRING" id="671144.I4Y986"/>
    <dbReference type="GeneID" id="18471102"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29467"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331815_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y986"/>
    <dbReference type="OMA" id="WIRNDNT"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="863" mass="97689" checksum="BE9BCA309348860A" modified="2012-09-05" version="1">MRGRVRNADIITALDVLQTGTYHGLPVGLRRAFKPEKPLSVTAVIAHLEQLNDVIRFRLRTKEIIPHSMKQIPYTIADGRVFFHVKNLFTCSVTLSGRSDDDIWFLLSVEFDIDSSVYTKKPKFGTRDEILAIANEELASKPPKTSALGDAPLVRLYNLLTNLSLNYKMEILHTQALNMARKTWKNKIDLTLSKDRRNLSIGYWLRPRQQPKPGQSPPPNQKTESGRLNISIATLSSEKQNPVESILNQIEIKSKLKATALADEIIEQCLQVDWTRNDKTEVEDAVLDLNNDNLSIERVVLQALVAHSVALLKRYKKSLCASSSWFNNATVQLQIPEVLGLGVSPTLHIQVFETQKLILSISPTTGRLIVRDPNESGTSAPARIKNLLDRMNEAGGISDNTPLLVEIVNRLRQSIAIEDIEQKCAYLQYKGTRRLKFAKGELNKLKLQARFWMFIHLPFANSSNNLFTMAIAIGESKVHVALIGMKEVNTELHVDYVGWLDTTKILAEETLTDHLLLDMNHIRILYAYSLARSNYIIIERQLKQRSVEFNFATTNTGSRLAGLIPHLTVHSNAFLRDHPSIANIFKPIAIVKVLDWWGASTSGCRIQAVFKPKGRSSILQKLKDKTSENVRYDYKSNVVEVTTTDNENTILEIIGQLTTFVKVTLIANQVSKDTRQFKLIESNLDNITLSYMDNYNVKLSWNSNKKMLYADFSGEGNPHKNVQEDMNRRLKSYVLDSGFFYRFTTLLLNTAKLIDTTKSLTKALILQRSSTHIRVKGMKEVVDIYLVNNRRVVIVDGTRALKNMIEPIIYSRLIHSEITSLDSTKKEILDKFAQQTKIIDSGVVLNNVDIGIKALPCFLLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A8</accession>
    <name>I4Y9A8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dbl-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959344.1">
        <property type="nucleotide sequence ID" value="XM_006959282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A8"/>
    <dbReference type="STRING" id="671144.I4Y9A8"/>
    <dbReference type="GeneID" id="18474210"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60856"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9A8"/>
    <dbReference type="OMA" id="TTEGNPD"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="249"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="473"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="868"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1260" mass="144109" checksum="BF13997A4D34920B" modified="2012-09-05" version="1">MHNAQLQSYVQSRASNVPNNNIINNNKLRRRTMDTSFPGDEYTEAYYDELQYNEIQSGLKGFDPFSIVKPQLIKDLAVQFKDNVPRGTHVKGSVPFETSFTGKDIVSTIRELFPTVVRNSSASRSLAVQVARTLQSQLYFFEVEFNMTLVTDDVQEIFVFPDEVGLQGAGSDEIPTGVFTALTPCYSLMCPGDETCYSYTCPYRAKKALHLVSATEIPHSEDIIDEEFKDWTEQVEPELLVTLDDQERERQSVIQQALESEIQYVEALDVVESLYIEPLRMVKPNIIPVERLESFIEATFDGLLSLRERNRRLVEQFKVRQREQSGLLEAAGDIFLSSFIEWEDCYPDYIGSLPTIESMIREEQGLNDQFSEFLLECERKPEAQGMDLITHLQRPAHRLGRYAVYLNAILKETPEGHPDCGYLVEGMKAVKRLTDLGTLVSWQLSDPNHSHIQGWTDLVEPEVIMNLDKKEIERQNNIFELIRTEMGYVKDLERFTTVFIRPLRDAKDSIIPNHRIDHFIYEVFGNHVDLFELHNTLVKELHKRQREQHPIIDSITDCVLKVALNWDEAYETYMPHYPYAKNAYDEEIMLNERFVEFVAACRRLPECRRQDLSAFLFLPPQRLPRYPLLLGDILKHTKDDHPDKINIDEVIDLIKSKIKEINVNVGVATEKVKLRNYSKIIIHRDGSQNGLDLANDARTLVHEDTVIRHSEGTTSMTTSNSDIKMMLFDHYLVLCKEKRVDKVAGRRVFYIWKRPIPLDLLTLNDFNGSPLKQTSRIRGALGRGANDEESGLIYPFSFIALCRPRLEYTLFTDDPQKRQRWQEKLEEALFLHSQVQEETNKVFEAVPLSIDTFPATRSAGAFEDNPLTGKVTCSVPFKTNDGRRLVAIGCAEGLWIGLRGEPTSLRRVLHLKNVTQCAVLEEFGMFIVLADKILVAYSVEALVPSASTIQNGGSNLSRTPQKLSGTKDVAFFTVGKLHDRTLVIFMKRKGIDSVFRALEPVSERMLAERAPVNAFNRLLTGGKSGWFENYQVFFIPSEATDLLFLRAKLAIICKRGFEIMDLETLKGGSIPDFTNAKNQRDPQISALGKKCDDATALAIFKSGDQEFLLIYQQFGFFVDRHGDPHRLECFTEWEGKPESVSCHPPYILLFDSEFIEVREMETLNLVQVVKGNEIHRTWGGIGLSPHAISPNGWVHSPEALGESRCHFVMRVDSEQRLSQGQRGNSSQRVFELQPIWHYNQADSSQLYQSTAPYRNYVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N4</accession>
    <name>I4Y9N4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959209.1">
        <property type="nucleotide sequence ID" value="XM_006959147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N4"/>
    <dbReference type="GeneID" id="18474168"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60796"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9N4"/>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="28019" checksum="06E99B2B959BDC1D" modified="2012-09-05" version="1">MSQSISDLVVRSITSTITIFSRPFSRYPGVPVGSRSTAIKLEEGENKDKVWVLASSRCDEVVIENIKKLGQVKYLVAPDTAHYLFLKQYIDAFPDAKVIGVDGLQSKASDVKFDYIYGQEPADKKVGYEPEIQVVWFDKFINRDLAFFHQPTKTLVQADLLFNLPGYEQYSNSKESAEPWVPFVQNFRPGTLTHRIAAMAMSKNDAEIKKVYEWDFDRIIPSHGDVIETGGKKAWYDVFSRYLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W3</accession>
    <name>I4Y9W3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_54968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959283.1">
        <property type="nucleotide sequence ID" value="XM_006959221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W3"/>
    <dbReference type="STRING" id="671144.I4Y9W3"/>
    <dbReference type="GeneID" id="18472705"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54968"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="I4Y9W3"/>
    <dbReference type="OMA" id="AKEMWQL"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="287" mass="30875" checksum="8D3CA345B35F6440" modified="2012-09-05" version="1">MASNLQASSLFNIEGWVTVVTGGGSGLGKMMATCLAQNGARVYITGRRFEKLQETASTYTDRIFPVAADSTKKEDIQSIIKYISQREDHVDLLINNSGVSTVKADLDANRSSEAVSKAMFEQSFDDWTSPYAINVAAIYFTTAAFIPLLTATQKHRGESGNVINVTSVSGIIKNSQGGQFSYNASKAGAVSLTNQLALELARPHLGIRVNQLALGYFPSEMSPILPGDNKGEYQSKWNIPFGRPGHAADLSKVILNLATNGYMSGSIEVVDGAYILASDNVDLSKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W6</accession>
    <name>I4Y9W6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959285.1">
        <property type="nucleotide sequence ID" value="XM_006959223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W6"/>
    <dbReference type="FunCoup" id="I4Y9W6">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9W6"/>
    <dbReference type="GeneID" id="18474194"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60832"/>
    <dbReference type="eggNOG" id="ENOG502RAFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376528_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9W6"/>
    <dbReference type="OMA" id="YYGWMKK"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="378"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="686"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="803"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="878" mass="96451" checksum="F73B6E21A909F5E9" modified="2012-09-05" version="1">MPFGTPPNNLDETGFSIYAMFDFDAEVGDEISFKCGQQIRVLETDKEYSDGWWVGVNEDGKEGLFPESYTSWARPIAPGIAPISAATGETKVGKQSQPGNTPSNTPKDDMKATMTEIQDAINEFNVDDPHKGSNNSLNDDSQDKQLLAPIVEQTNSKTSSQITVSTDDNTDDDDDEVNAKARSLLAKKNAQANGSNNAPTSLEFGEDSDEDTTPHTATAPRNELLVPSKDPAEVIPESPLDAMMPRQPVQSKPSGLKNTYTPTGEVDDKQDFKKPSIPSSYPLNAHDPTPTIKPIENNPRDSGSAQWDNKREKHDSRDYKHDSRDYKHDSNSTQKASKPISHSSLPPVNTAIANTQRASQETSKSSNSRNSYENVEQWSVERVIEWAVSKGFDTSIKDKLREHEISGDVLIEMDAASLKEIDIIAFGKRVKIANAIKELRSQAGLDVQHSQPQSASTGRPGSETSSMRNASGGNYTTSVASPVDLNEDMPSRPTSFAQRTGSGLLSHKNSGVLEQTPEEPEREHDQVIAVPEKVPNQTDSPKAGSATASLKRAFSGSTTHSPVMHSPRSSAAKKHTSDTSAFFGVGSKGNPRKPAPRYSGASNDTNSPEEKSRKPFSASRLLGSKRSIRNMNGSGASTRSSLSPQTAQNDSQFVDTISISSDKRRSVVDITNFQEREGTALQKIGRCDCKGWMKKRGDRYGWKMRYFVLKGSQLFYLKNENDKQLKGFIQLNGFRVMNDESNSSRNNFAFKIVHESEKDVHYFASEEKSVSREWMNALMKASIVRDVHAPVVSSCTIPTIPLDQAQTMFPPPRPPSPGSRERVQRANVRDNPDSLSPEDARVLMAGAPDTPNDKRRMTTSSFGNLSSSFGNDDREKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF1</accession>
    <name>I4YAF1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_54784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958937.1">
        <property type="nucleotide sequence ID" value="XM_006958875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF1"/>
    <dbReference type="FunCoup" id="I4YAF1">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAF1"/>
    <dbReference type="GeneID" id="18472694"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54784"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="I4YAF1"/>
    <dbReference type="OMA" id="MCWDIRT"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="32578" checksum="5D82DAE75AC7E0FF" modified="2012-09-05" version="1">MSSSLPPLKTKLTGHNGPVNVVKFNNQAGRYCLSGGRDRSIRLWNPHLGSEVKTYQGHGWEVLGLSITQDNTHFASCGGDKSVFLWDVQAGAVVRRFSGHNSKVNSVAFNHDGSVLASGSYDSTVRLWDMRARQRLPLQILDDAKDSVVDIHIAGDRIFTASVDGYLRTYDLRAGQLRQDFLDYSVTSVTPTADRSAVLVATLDNKVRLIDSATGSLLALFEGHTAESFRARSCLGSGEATVLCTSEDGRLFLWDLLDGKVLSDSKAHEKAVLWVDHHPSRPEILSAGSEGVINFYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAG5</accession>
    <name>I4YAG5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958950.1">
        <property type="nucleotide sequence ID" value="XM_006958888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAG5"/>
    <dbReference type="GeneID" id="18474078"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60658"/>
    <dbReference type="HOGENOM" id="CLU_1994376_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAG5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="14243" checksum="9183CBB0812A1B18" modified="2012-09-05" version="1">MIQGMNLINNVARTTRLPSTTASFRTFRHIHNTAAWRKPNSARADEKATSSWPEGSSSHPHTDYHPVEGREGKTARLIFRIKPSDIPTELLPLFAAVGLAVVGATGYGVYALINDKTLRVHNQPERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAH5</accession>
    <name>I4YAH5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958959.1">
        <property type="nucleotide sequence ID" value="XM_006958897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAH5"/>
    <dbReference type="GeneID" id="18474079"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60659"/>
    <dbReference type="HOGENOM" id="CLU_1305722_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAH5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697550" evidence="1">
        <location>
            <begin position="29"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="211" mass="23633" checksum="6AFF5681829C2489" modified="2012-09-05" version="1">MEYLRWRNVLKTSIVILLMSSMLMFVQAVPDLDDHQRKLESDLVQLSEYPNTVENGYNAVQSGPFNVQWSTIFTYTNYLVSWGGACAAIYSTISKFQSDKADRIAKESCKANKFNALGYGFWIIPDARKCDPGTASKVLETAVSDALHPLRGVSNAVGCVRINDWYDYSAYVVVLPSPDNNSFCEGKGITHRSATSDSSRDIQYETKRNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAI5</accession>
    <name>I4YAI5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_29185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958968.1">
        <property type="nucleotide sequence ID" value="XM_006958906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAI5"/>
    <dbReference type="STRING" id="671144.I4YAI5"/>
    <dbReference type="GeneID" id="18471085"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29185"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="InParanoid" id="I4YAI5"/>
    <dbReference type="OMA" id="VNWEDQF"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="522"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="946"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126748" checksum="60C54C4418B59EFD" modified="2012-09-05" version="1">MIPSNYIQTPPNIWKDVRLAYVPQLKQSAQSSPQETIRVYPPAELLGQAPGASVGAGQMRIQDSFAVVDRRTAGVLGPLMLQRCVRIEGVVKTKDGSPMMLPMRLLLFTRRDLMEKIAHVILQSGISIDAPLMYDPKKHCNAQYQLPAIVSDIKQRKTLNRFGDSPFIPPHSLLNNGSSSLNSYSYRPQFSGNSKTTEINRSVQANEMLGKISVDNELPETEPSDEVKTTLYPHQKAALTFLLETEREPRRKTDLSDKFSFWKQTKDKKKYQHIITHNYLNKEPPGCRGAILADDMGLGKTISVVALIASTRESAHEFASTELEVDSDTTPKREEMPAPPTSQFSNFAIHGMPTSNTGATDALRMEDDDTLEGKTQKMRRQRQERIITRSKATVIVCPLSTLSNWEEQFLDHMAVQPRFYRHDERPKKKNDGALHIYIYHGNGRKREASFLRKFDVILTAFSTVATEFSKQQAAIDKLEKAEEQWDEMLKNGTAYSSTAATTDGFSDDDVTFIKSGSSSIKPTKSTASSASNSSTTKGKGKGKRKKKGEGDEIEGLCPELLAEMRENVVNAASPLQQIEWFRVVLDEAHYIKDPSTMMSKAASEMAANRRLCLTGTPIQNKIEDLYALLRFLHLEPFDQRETWNTYIGLPIKSNLNVGFARIQIIMRHITMRRTKEMKNMDGTPIVTLPDRSDELRSLEFNPRERAIYDNQHGKSKGKYVELRDSDGLSRGGFISILQELLRLRMICDHYCLCPDAVNAFAESPTAQAQAIFQVMRDSETANCIDCYYDFVQSQAPGAQKEEEEDKPLVEDKIFKKPKLESSSNTPQSTGSAMVLPIMNLQCNHLICSSCIKKHVRNWPEFESFQCPDCKEVVSDATQVIQIDNFNETFASVENDLSVFENEVSTSKRKKKIEKPEEFSTKIEALLHDLAEISTTNPHSSNFNTLNFDADIKAVPNKTIVFSQWTSMLDLIEFGLRECQIGFSRLDGSMQRDQRAHSLERLKNDPKCEVMLISLRAGGVGLNLTTANRVYMMDSWWNVAVENQAVDRVCRIGQKRPVQVVRYIIQNTIEEHILEIQERKTRLFKGVLGSGRQRSKEEERKEMLENIAIMFGDSPDSVHKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ3</accession>
    <name>I4YAJ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase subunit beta</fullName>
            <ecNumber evidence="17">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_32961</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="17"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958974.1">
        <property type="nucleotide sequence ID" value="XM_006958912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ3"/>
    <dbReference type="FunCoup" id="I4YAJ3">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAJ3"/>
    <dbReference type="GeneID" id="18471595"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32961"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="InParanoid" id="I4YAJ3"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="198"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="529" mass="56726" checksum="24F05EF4A87BCB6D" modified="2012-09-05" version="1">MLSRNILSRVARSTAAASVRRANAAAFSTARFAPAMAKPTISKVQLKATRGYATETAQVGNIKQVIGAVVDVQFDTEDLPAIFNALEVQHNGPKVVLEVAQHLGENTVRAISMEGTDGLVRGTKVVDTGAPISIPVGPKTLGRIINVTGDPIDERGPVEGVKRSPIHAEPPAFTEQSTAAEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNVAKAHGGYSVFCGVGERTREGNDLYHEMIETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDDEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGAMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGIAELGIYPAVDPLDSKSRMLDPRIIGEEHYNVATQVQRILQDYKSLQDIIAILGMDELSEEDKLTVERARKIQRFMSQPFAVAQVFTGFEGKLVSLADTIRSFKEILTGKYDHLVESSFYMVGTIEEAQAKGEALARESAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ5</accession>
    <name>I4YAJ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_32965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958976.1">
        <property type="nucleotide sequence ID" value="XM_006958914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ5"/>
    <dbReference type="FunCoup" id="I4YAJ5">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAJ5"/>
    <dbReference type="GeneID" id="18471596"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32965"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_1_1"/>
    <dbReference type="InParanoid" id="I4YAJ5"/>
    <dbReference type="OMA" id="ASRFNCT"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="34"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="201"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58634" checksum="5C6C1CF88C743605" modified="2012-09-05" version="1">MISLTNSENHLCEILSGCTAKLRREDASLAALELRIAGGWVRDKLLGKPSDDIDVAITPLTGLPFAEALAEYLQSIEPQQKISIARIDANPNQSKHLETARMKVSGYEVDFVNLRSETYATGSRIPQMSLGTPLEDALRRDITINSLFYNIHTRQVEDFTGKGLEDLKNGLVRTPLEPFQTFSDDPLRVLRCIRFATRYGFTLDNTIIEAAQRDAIRRGVCENVSKERIGTEIDKMLNSQQPLEALTNLSKTKLHDIVFGVSGDGVEGDALEASYALAAGHLLQYALYEPAKLGITERLSQFVTQDKLLIRRLWLGVALIPYFNMQVKEKKKIVTAPAFIASNCLKYGNAERAHIDNLVLGCNFIRENIRGIDLNDRVALASALRHVNVHRSAQGTDWAATVLFTLLQELLEVYYRSGCNDDAFRSDDITSVVGLYNTFVESAVTTLDIPRELESRPILDGKRIISVLHLKPGPQIQEINEKVILWQLRHPTGGEAECEAFLLSEQAEGRIPGPQAVDDAPKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAJ9</accession>
    <name>I4YAJ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958980.1">
        <property type="nucleotide sequence ID" value="XM_006958918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAJ9"/>
    <dbReference type="FunCoup" id="I4YAJ9">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAJ9"/>
    <dbReference type="GeneID" id="18474089"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60672"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="InParanoid" id="I4YAJ9"/>
    <dbReference type="OMA" id="IPKYQES"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="405" mass="44636" checksum="2E820489954C8E53" modified="2012-09-05" version="1">MLRSLVRYTKSALDKLPNKVDFELKPLGRLNKQVTSKRVPHVTQSVGSMFGGNHSLKWTSQPRNVLIVKKSDSECSTRAMEEVIAHLRTNYCDTNIIVENGVKEELKASRELYTTTETDEFTLSSKVDFAITLGGDGTALHTASLFPTGPVPPVLSFSTGTLGFLLPFHINSYKSAIDDVLNSNVSVIKRMRLMCTLHDASGGLIDDLDVTHVLNEVALHRGRYPHLVQIEIYVDGMPLTETVADGLIVSTPTGSSAYSLSAGGPLVHPCVQSIVLTPICPRSLSFRPVILPSDSTVQLRMSTKARSKPDVSLDGREVMQLDSDNYIQISMSPFPLPSINRAAIYDPESRQGTPRLPSEKQLAQSALDRLGRAQDDWVRDINDLLNFNSRFESKGQEIYHGGQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS0</accession>
    <name>I4YAS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958747.1">
        <property type="nucleotide sequence ID" value="XM_006958685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS0"/>
    <dbReference type="FunCoup" id="I4YAS0">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS0"/>
    <dbReference type="GeneID" id="18475549"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69223"/>
    <dbReference type="eggNOG" id="KOG2997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017706_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAS0"/>
    <dbReference type="OMA" id="RWNRLDF"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="402" mass="47136" checksum="ED1BC9D482D0D1D0" modified="2012-09-05" version="1">MTNVNDLETFRREWQSELNKDHSERKEERIYHDTDVAVECYKQAVEAEQVGQLNDSLILYRKAFKLDDQVDKQYGNYIKQKQAREAEEIAIDSVTTVETVKNDIQINEDGKHTYNFSKTIQTGPDAPKQSTYRLDAIDKLIQSLNENLRLEADQEDEECPISTLPDEIILNIYRHLVHKSDLQTLMRFACSSRKLLVLSNDNIIWKDLVKTHLVPPYQIKQSIDVDDIATYKFNGAWRKLWLDIPRIRLDGVYISVCHYLRHGESESAWNTFTQLVTFYRYLRFFNDGLVISWLSTDVPNQSVPTITKDMRSKGLLHGYWKLRGDLILISDLKDPDRVRVPYRFRMKAKLKSSVHGKHNKVDLMEYTSLNNEEEEVSIPLKHQRPFYFSKVRSWTALTPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY7</accession>
    <name>I4YAY7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_4122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958731.1">
        <property type="nucleotide sequence ID" value="XM_006958669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY7"/>
    <dbReference type="STRING" id="671144.I4YAY7"/>
    <dbReference type="GeneID" id="18472208"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4122"/>
    <dbReference type="eggNOG" id="ENOG502S419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2549376_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAY7"/>
    <dbReference type="OMA" id="PGCMKLF"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="83" mass="10378" checksum="507349981254610B" modified="2012-09-05" version="1" fragment="single">PTCLSLFDAYLSCYTLRPQLLSIYRYAEYKKCDRPWDDFKWCFFNNKLDDEQKLKAWIERRADWWARRRLNRSSEDVWDARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB98</accession>
    <name>I4YB98_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958595.1">
        <property type="nucleotide sequence ID" value="XM_006958533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB98"/>
    <dbReference type="FunCoup" id="I4YB98">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB98"/>
    <dbReference type="GeneID" id="18471544"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32706"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_0_1"/>
    <dbReference type="InParanoid" id="I4YB98"/>
    <dbReference type="OMA" id="LWIFSAC"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="300" mass="33319" checksum="1CB3979A79A0A9B1" modified="2012-09-05" version="1">MSDNSSAYNYDTEDGFPTLSATVTFTVFFALFTAAHIIQAGWKKQFWLYGTIVIFGLLEVIGWAARCTHARTGYIIQTSLLVISPCFLTAFIYYDLKHVIHLYGPKYSLLPAKTAGWLFIVIDIICILIQAAGGGIAASASSGNSDDPEESADTMKLGSHIVLAGIILQLVTVFVYSCFLAEFCFRYYTNKAARSTYTTAAVIRLSSREQLKLKLRLGILSTISVLVLWRSAFRVAELNGGWEGELMQNQDAFDANDGVPMLLSLIVCSFLHIGWLNPEKEMIRSKQDSYTSTEDKHELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBH4</accession>
    <name>I4YBH4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958668.1">
        <property type="nucleotide sequence ID" value="XM_006958606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBH4"/>
    <dbReference type="GeneID" id="18474004"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60523"/>
    <dbReference type="HOGENOM" id="CLU_349225_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBH4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="807" mass="93448" checksum="F2D6EDCCF6AA9E56" modified="2012-09-05" version="1">MDNQPFETVLGKLQFIDINDHSYDSIITIKFWFLNLKAAEEGNDLVTENKLDILEVVSDLYPDFALPAMYYVMCIRETFRQRTSRLPVTPEILEIHHDIEAEKLERSRQSSLNWMNNAFINDSQPDLSFVEQLVNDYEGFYRQRPLIPQLPRTFHRTSDRQRKVEVDKRLRFIEQFIEQNEDKVDKVETRHILRNSLEQNENREDLIKSKPALRNSQRNESQEEKKERALKDYMLTNDFSEHHDIIISLKSRSISTEHLNASEYLVHVGKEYADRVRKSYQTQLWQNDSNIILSIDSWKLKDSKHDIMTIHSTPLGTDESRLVHTCMKDGRNDILNSISRPSKANVTTLVVDHSSSFPYVKHSYDILLQDVLSAYNSAFVACLSAAKLDGVVDTLIKLVKTLHKSKLINHVLKKLLEVRKQDLPKKPSHWRYFGVFHSATQVLHVLETILMIGESKSAKVRQIFDNKIGQLLKANLEKFILGLHFITRVFSPFDFGFEMLESPKLRLDQVHTLYCWTIQTMADLMRSQSKLELTWSFDAPLILSAFAENYRWLRTINNVKTSINPPFNTQDIDLHWLALFLNPNMQLSDFQAPFADDLTRSLRGRLSPSSSSNYFFSISEAIKNMYIATHQNISNEDTANVQYTINSDLYRYISKSGEFARSEGTDPFVWWSEPSRSKSPLAFVGAQLLGTRPTTMTAKRYNNTLRWSIDEPSETADSDSICEKLLLREYFNDEENVPDISGDFSTAERTQFIPTTVLDAKVNISKGNGTDYTLEHTSTDFEPSKLLEEVAVELCMNTDYIETFLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBK7</accession>
    <name>I4YBK7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958697.1">
        <property type="nucleotide sequence ID" value="XM_006958635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBK7"/>
    <dbReference type="STRING" id="671144.I4YBK7"/>
    <dbReference type="GeneID" id="18472941"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57655"/>
    <dbReference type="eggNOG" id="ENOG502S6UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047273_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBK7"/>
    <dbReference type="OMA" id="NPFRVQW"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31434" checksum="ACFC17B93132D0B8" modified="2012-09-05" version="1">MDVQDQAARNVKNKHSLRNKGKQSTGDRKPAFKTVLDTPYHVNWPGVPPSTSNAILKDLTAFFSDFVKKKELTHPPLSDEQKRALRKERREAKLKDKGSVTLNPEKGKDRENITTPESTLLGINAVTRDIESGQSSKCKVVIACKHDVNPSRLLAHLPIQISTLNTQHKRSVLLIELPKGSEEALAVSIKLKRVAVVGLTENHILAETIRRRLEDESKYTLKAPWQTEEGDPIYIPTQIKTIETTMPKDLRKAKEEKKKTQAAKKERILAYKQTQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL0</accession>
    <name>I4YBL0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958700.1">
        <property type="nucleotide sequence ID" value="XM_006958638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL0"/>
    <dbReference type="FunCoup" id="I4YBL0">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBL0"/>
    <dbReference type="GeneID" id="18475544"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69195"/>
    <dbReference type="eggNOG" id="KOG3267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_0_2_1"/>
    <dbReference type="InParanoid" id="I4YBL0"/>
    <dbReference type="OMA" id="TWQGIFF"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="15470" checksum="988F79266A02E68C" modified="2012-09-05" version="1">MPYQKTITLNKRSKGCHLVTEEVVNQLRDGISNTQVGLLNLFIKHTSAALTINENFDYTVRTDMDMALDRVVPESLPWEHVDEGPDDSVSHTKTSLIGPSLTIPITNGNLALGTWQGIYLTEFRHLPHTRKICCTIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL4</accession>
    <name>I4YBL4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958704.1">
        <property type="nucleotide sequence ID" value="XM_006958642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL4"/>
    <dbReference type="FunCoup" id="I4YBL4">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBL4"/>
    <dbReference type="GeneID" id="18475546"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69198"/>
    <dbReference type="eggNOG" id="KOG3131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062516_2_1_1"/>
    <dbReference type="InParanoid" id="I4YBL4"/>
    <dbReference type="OMA" id="VVTRKKW"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="28203" checksum="47F972BAB4CFC574" modified="2012-09-05" version="1">MDGFKYKAYKPKSKGGNRRNKNQLPINLEVNSNDKLTGALYHRRNVIKQSDWFKGVQHTFDSVISSDNWPTPAKIIALGLGSFEDNRNAVDQLVLLEYIIEKLQIAPNNVSLYDPVCTETDKDFVKQFGYDYIQDSDSIHTNNNCNTFLYMPHCDKVLYEATLSSYWSADKLSTVVLLGNDLSLYSNRQKDKGNVSLVSKFLTFSESNNLPNPPDDLINSFNELCFQYVPSLRARWLNEEYWNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBP1</accession>
    <name>I4YBP1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="17" type="ORF">WALSEDRAFT_54681</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958728.1">
        <property type="nucleotide sequence ID" value="XM_006958666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBP1"/>
    <dbReference type="FunCoup" id="I4YBP1">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBP1"/>
    <dbReference type="GeneID" id="18472683"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54681"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBP1"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="13">
        <location>
            <begin position="276"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="529"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="16">
        <location>
            <begin position="763"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="637"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114568" checksum="B9DF4C742B5DDEE1" modified="2012-09-05" version="1">MSSVKQLDSRVRSLIENGVKGNHRSFFVLVGDRGRDQIVNLHYFLSQARSSSRPSVLWCYKKDLGFTSHRKKREQKIKRDVKRGIREPNEASPFELFVSVTDIRYTYYKDTPKVLGQTFGMLVLQDFESITPNLLARTIETVEGGGTVVLLLKTMSSLKQLYSMSMDVHQRYRTESQQNPVSRFNERFILSLGANPSCLVLDDELNVLPISKGKDIKPVQAPPKKNAELDIIKEELKSTDIVGSLVKSTKTVDQAKSLLTFVEAIAEKTLSSTVTLTAGRGRGKSAALGLAMAAALAHGYSNVFVTSPTPENLRTLFEFLFKGLDGLGYEEHLDYDIVQSANPDFQKAIVRVNIFKHHRQTIQYIQPQDAHVLGQAELVVIDEAAAIPLPLVRNLIGPYLVFMSSTINGYEGTGRSLSLKLIQQLREQTRPTISKETNDGPTKKKGQPEGATTAGKARTLRELKLEEPIRYSPGDEVEKWLNGLLCLDATVTSKAALKGTPHPSTCQLFYVNRDTLFSYHPASEAFLQRMMGLYVASHYKNSPNDLQLMSDAPGHALFVLLPPLRGDETSLPEPLVVLQVAFEGQISKESILNALSKGQRAGGDLIPWLVSQQFQDENFAQLSGVRIVRVASHPDYSNMGYGSRALEQLNSFFSGELYEGSGEDNADEVFDRSEDSGDLMSDNIKVRDASSMPPLLQRLSERKPEKLDYLGVSYGMTENLLRFWKRRGYVPLYIRQTANELTGEHSCMMIRGLNSSTEETAGWLSAFAQDFRRRFLSLLSYKFREFPSLTALTVLEAAAIGTNDEEGGEELSANELRYFMSPFDMKRLESYASNMLDYHVIVDLLPHIAMFYFTKRFGDEKLSAVQSSILLSLGLQRKQIEDVEAELDVPVSQALALFMKSIRRMTKRLQDVEKQSIGESIPTASTQIVRKTDGGTADWSRVDQDIEEELDEAGREALKTAKRDAIDSLDMKKYALPQNDDDWKDAEVAVDQGKTSVSVKKRKGDDSPEKAAKKSKKRTSKGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBP6</accession>
    <name>I4YBP6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_38335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958422.1">
        <property type="nucleotide sequence ID" value="XM_006958360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBP6"/>
    <dbReference type="FunCoup" id="I4YBP6">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBP6"/>
    <dbReference type="GeneID" id="18472059"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38335"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="InParanoid" id="I4YBP6"/>
    <dbReference type="OMA" id="NGSMEAW"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="44376" checksum="A6B7D416D9F26C2F" modified="2012-09-05" version="1">MATTSEFTEKSFSIADADKNAKFNTKDDIKPILDKLQSQLDVEDVHFSGVSIGVEAAIALSEKLPELKSLRIADFSDIFTGRLITEIPQALKSICDSLLKCPKLEEVNLSDNAFGGRSAEPMVNLLSNHPNLQVLKLNNNGLGIEGGKIVSGALKSLASHPEGSKLRVVVCGRNRLENGSSDSWAEAYSLHKNTLQVVKMPQNGIRPEGITAILGGLTNCNDLRELDLQDNTMTKNGSIALSNAIKSWSNLEVINISDCLTGGRGGIEIAKSLATGVLKELKTLRLQFNEWDERSLSLLSKYINEFGQKLTTLEINGNRADPDEDVIESIREALSKHNHGNALDELDEMEEYDPEDLEEESEGEQSDEEDEGQGESAKVIEEIKEKKQESGDVDDLVNQLAGAKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC30</accession>
    <name>I4YC30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_32684</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958549.1">
        <property type="nucleotide sequence ID" value="XM_006958487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC30"/>
    <dbReference type="FunCoup" id="I4YC30">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC30"/>
    <dbReference type="GeneID" id="18471540"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32684"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="InParanoid" id="I4YC30"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="21">
        <location>
            <begin position="195"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="21">
        <location>
            <begin position="489"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="629" mass="69945" checksum="98DFAC84E50FB6F9" modified="2012-09-05" version="1">MQVNSSSRLRSSQLERSPNTKSAFLYPRPSLPSLSTTSADNLPDARSYLQTKLDVPTKSLLSHDEYGICNNPDFRYTSSHNSRENSTISEVEDPSYFILISTYVSYVLLIVVGHMRDFFGKRMFKKHYKHLMPNNGYAALLSDFDSFYTRRLKLRIDDCFSRPTTGVPGRTIVTLDRDSADYNNTYNYSGTSTRCLNVSSYNYLGFAQARGGCADAVEDCIARYGVSAGGPRHEGGTLDLHHQAENLVAKFLGTEAAMLISMGFATNSTTIPALVNKGCLVISDELNHSSIRFGVRLSGASVRQYKHNDMKELENLLRETISQGQPRTHRPWKKILLIVEGLYSMEGTLVNLPVIMEMKKKYKFYLYIDEAHSIGALGPSGRGVCDYFGIDPRTIDISMGTVTKSFGAAGGYIAGSSDLVNRIRQRSHGMTYAESMSPPVLTQIISSLASITGVKEFIEGGDQVSEEIHPGPITYNTLPSWMTLPRDLLDGSEGKDRLRRLAFNARYLSSALRKMGFIMSGSRDSPIVPLFIFHPAKLPLFSRLMLERLTKDAASIVVVVVAYPATPLISGRVRFCLSSAHTKADIDELLRACDEVGDILQLKLSKRENKWTVEECIDRAVELVESEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC63</accession>
    <name>I4YC63_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_28619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958255.1">
        <property type="nucleotide sequence ID" value="XM_006958193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC63"/>
    <dbReference type="STRING" id="671144.I4YC63"/>
    <dbReference type="GeneID" id="18471052"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28619"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_1_0_1"/>
    <dbReference type="InParanoid" id="I4YC63"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="42145" checksum="D6932EB7D5814E1B" modified="2012-09-05" version="1">MTEIEEKPKKALYEDDSDDDDDIVQSTDIDHTPVAQYLDDEDLEEEDEFEADRQRIGGEEIEDDYENEDGSSEIPSAASSNEEEDIDDVEAQYNSLPLSALAEASSRLDDSNDNEEADKRKSKRAEAIAKAKEELWEKQQSKGKDNKEKERKELQKRANKHAPTEVTSKRPTSRKREVVEVDKIRSRDPRFLSLSGNFSQDLFEKSFSFLKGSLSKEVAEAKEQLKAAQLNIRRARSLPGQSEDKTYLIEEHQAEVDRLTHEIQRMSSQAKTSQKKDIEKEALRKIKKEERDKRGEGKKAYYLKDSEKRKRVEEAQKEVLRAQGGNKAVKKSEERKRKRHEGKEKKSLPWTKTGGRDSVGTKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP3</accession>
    <name>I4YCP3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958046.1">
        <property type="nucleotide sequence ID" value="XM_006957984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP3"/>
    <dbReference type="GeneID" id="18474884"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63968"/>
    <dbReference type="HOGENOM" id="CLU_1662172_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCP3"/>
    <dbReference type="OMA" id="YLCMHAY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="159" mass="17909" checksum="A18C87CD035CE604" modified="2012-09-05" version="1">MAFSKFANVFRGKFSKTKDEDYVGNEHISSPELVYHTNKSMVNLLDVQTPHHNTKSRGKKKARNSLTLESPPRSRAKSMIGSQQITQMGSMSQYCGYHPIQDGEPCGHGIKSEVRSPRKSLHSGFNSKHKPRRRAFTIDDDDIPPVPPLPAIYTNTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD49</accession>
    <name>I4YD49_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958192.1">
        <property type="nucleotide sequence ID" value="XM_006958130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD49"/>
    <dbReference type="GeneID" id="18474904"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64125"/>
    <dbReference type="eggNOG" id="ENOG502SFJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169797_2_0_1"/>
    <dbReference type="InParanoid" id="I4YD49"/>
    <dbReference type="OMA" id="SKKAGHE"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="58" mass="6162" checksum="7BD5B2F8413FF34E" modified="2012-09-05" version="1">MSNEAAQSGGQMDALDKGVDAVANKLGHKQSRSTVEKISDGSVYKKLTGKDVPIQDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD73</accession>
    <name>I4YD73_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_28593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958210.1">
        <property type="nucleotide sequence ID" value="XM_006958148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD73"/>
    <dbReference type="STRING" id="671144.I4YD73"/>
    <dbReference type="GeneID" id="18471050"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28593"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012204_1_0_1"/>
    <dbReference type="InParanoid" id="I4YD73"/>
    <dbReference type="OMA" id="GDILWPG"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="10">
        <location>
            <begin position="768"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="711"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="923" mass="90243" checksum="BC9870ECFB01B11C" modified="2012-09-05" version="1">MDYSRGTKNSSQAPSTAGFGASTSGGFGSAFGASNPAGGTSAFGQSAGTGFGSNQGTGGGLFGASQPQQNTAFGGSSTGGGLFGQTQSQPAAGGGLFGQSNTQSTPFGGGAATGGAFGQQPPKPSLFGSTSTSTPFGGGTSGGSAFGQSNPPASTPFGQSSTGGGFGSNTGTTGGTGFSFGQPSNTSTTTGGFGAPAAQPSTGGGLFGQTAQKPAFGAAPSTTPFGQSSGGFGSGSTGGFGQPQQPSQPAGGGLFGQTQPSQPAAGGGLFGQTNNQQQSGTGFGSGFGGGGFGQQNKPATSGFGGGFGSTNTTGTGTGTGTGTGFGGGFGQNQSSTGATGTAGTTGGGLFGGQQNQQQPPATGGFGSGGSGFSFGQNNQQQQQQQPQQQSSGFSFGGGLGGAQNKPATGGLGGFGSNTATGATGGGGLFGGGLGSSTNNTNTAGTGGSLFGGGTNTNTSSGGGGLFGGGASTAPKPAGGLFGSTGTGGGFGQSTTQPAQTNTGFGGGSLFGQSTQSNPLQQSQPNLSASVDQSPYGVNPLFDLGPNPPIGPHAVAVGGAAAAAASTKKKPVFSASASVRSPARPLNRLRGFAASPGTPLSPSSGNFSASVMPPSSPSMSINGGLRSSQRSLSLSRAGSPAASTNGGVLGGLPSENAMSPNAFMPRSSVKKLVIDRKPIPDSPSGGIQSPGVTPSKAGAKVSFNPHLEKAAQDSLGDSTTISQHENTPLKTSTNSQFVRSTTPSASPAPSTHTLASSVASVEATPQVEDGEYYCIPSLDELNKYSYRELKSVEGLKVGRKGFGEIRFLEPVDLTSLDGLSEVIEGNLISFEHKVVYVYPESVEEGEDNPNNAPIKPAPGQGLNVSAEIELDGCWPKDKSTGEFIKEENHPRLSTHLNRLKKVPGTTFISYESEPGRWKFQVPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDK5</accession>
    <name>I4YDK5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957852.1">
        <property type="nucleotide sequence ID" value="XM_006957790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDK5"/>
    <dbReference type="STRING" id="671144.I4YDK5"/>
    <dbReference type="GeneID" id="18473772"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60147"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517970_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDK5"/>
    <dbReference type="OMA" id="SEPDENW"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="547" mass="60997" checksum="409469EDF2946440" modified="2012-09-05" version="1">MKNKSNKSASSADNSSDWRSKDKSSIDDQIISLYRSSQPSQQIINKRLELIARLSNIISTKYGSNYSVESFGSTCYQVSSSSSDLDLVIIDKDRPHGFDPSVDVYQLPSAYNPNNLAKTLSSNNLKSVQPIFAAVPIVKFTDPVTNLQCDLNANNLFGIRNSLLIKSYLDLSPIARPLVLAIKHWAKLRGLNDSAGQYGPTTLSSYTLILMVISFLQFIGHLPNLQDADQIKAARLPEHRLWVRPPVKRRDSKRDQQKPPVETTTTQGAQAAPAIIPHPPDVRVSFDTTFVKRPLGNFIPTNLSLSTALAGFFYFYSNEPSNSLNEFWGIDEPFNYETSIISMKYGGIIPRDDLFVDIYNRNLDGNINLTTTSVNVQKNTTTVSAQQPLQWREQLLVTQDPFITTRNTSTNVRPQTSRHIIEEFQNGHKAISSGKCYDDICKKRTTPFEGEPGPGSFRKAQRKVTNRRRKGNGKGEKSAKSTATETNKKSTSDSQKSTNKDKSSSESSKPEEKAVKEVKRKRKSRKPANKSTTVVIPKNNQASTAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDM0</accession>
    <name>I4YDM0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_45191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957866.1">
        <property type="nucleotide sequence ID" value="XM_006957804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDM0"/>
    <dbReference type="STRING" id="671144.I4YDM0"/>
    <dbReference type="GeneID" id="18472356"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45191"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418092_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDM0"/>
    <dbReference type="OMA" id="QHSIPID"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="656" mass="74965" checksum="3E65FD99C2FF88FD" modified="2012-09-05" version="1">MEDWLKRRKELKNIKFDDNNVKFNQLHINQKDFIKLKLISKGQFGSIELVKCKLNGSFYALKVMNKGFSKRNIGFSNPTNEKAVHLLAATRNTSNCLPLVSAFQSPDDLFIQLPLAINGNLLELLEQNTRFETKTIKLYSSQLLNALTWLHDDIGWLHRDIKPQNILLSSNDHILLTDFGAAVPLLNNTRKAKKSDSLGLVGTTDYVSPEILLAAEEYLIAEQTGSSIHYDEKSPGLYGPETDWWSFGVVLFELAYGVTPFFAETVGETYNKIRQRSYTLGQDTNGELRHLLDCLFKPQTERLGYYGTKEVRNHAFFRHTDWESMSKRKIQTTYFDKTLDELVEDDSIAVEQPAPQKAFDFSALFQAADSISLEAFNESFQQSNNWNEFNYIPPVQDLFPSYHTRKTPETPFKLSFNNTTSTHKNRNLSEEQAFIEMQQCVGLSAKKRLDYSFNLDTLPRAVSYSSDLSSVDDNTQNDGGGYRESPLKRVESRSSLSRMNSQQSVHQPSLSRMNSQQSIHHPGLSRMNFQQSIHNPSLSRMNSQQYVKQPARPALRKNFKSSPNMRLDSGPRENSLSTRASSSRLARPSRLNVLDDLPENENNNPTTSTPHAPKNLHSRMDNLKKRHDALLKDLNQTSRRHEKLLARSSSRQSLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR5</accession>
    <name>I4YDR5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957909.1">
        <property type="nucleotide sequence ID" value="XM_006957847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR5"/>
    <dbReference type="FunCoup" id="I4YDR5">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDR5"/>
    <dbReference type="GeneID" id="18471449"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32259"/>
    <dbReference type="eggNOG" id="KOG2239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057806_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDR5"/>
    <dbReference type="OMA" id="SQKMIFA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="183" mass="19695" checksum="6AD57B592AA31F86" modified="2012-09-05" version="1">MSIEEIQENVENLNFSEAGPSNAGTQSRAEKKARQALQGLGLKKVQGVTRVVLRRPRNVMLVASNPEVHTAPGSGIHIVFGEFKVEDPSQIQAASQLADQEGQEKTESKKPEEIMAEMDSQAQNISEGKGKDVEEEGEVDETGVDAKDIELVIAQVGCSRAKAVKVLKENNGDLINAIMAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDT3</accession>
    <name>I4YDT3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_68595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957927.1">
        <property type="nucleotide sequence ID" value="XM_006957865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDT3"/>
    <dbReference type="FunCoup" id="I4YDT3">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDT3"/>
    <dbReference type="GeneID" id="18475435"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68595"/>
    <dbReference type="eggNOG" id="KOG4126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="InParanoid" id="I4YDT3"/>
    <dbReference type="OMA" id="RSGMEYP"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698820" description="Alkaline phosphatase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="53990" checksum="164E2092F8CB0060" modified="2012-09-05" version="1">MKLPTSIGLFCALALVSAQPTNKEQKNVILSISDGLGLPGLTMSREYVRNLETNGNFLNYTYQLPLDDDMVGSLRTSSANTYITDSAAAGTAMATGKKTLNNALGVDVDGNAIGSVLEAAKLAGMHTALVTNSYVSDATPGAFNVHSQSRDDYWFIAEQILGFRGALGIPAADIVIGGGYCPFIPKSAEGSCRPDDRDLLQEAQEKGWTVARTIEELNEADSAPLIGVFDEKAMNYTLDLSEDEPSLMQMAEKALEILIKLSNEDGKGFFIMVEEGIIDYAGHDNDPVAHVSSTLNHMNVHVRIKELLKQINGETLVVATSDHDTGQLGLGTSLPTDAELGEYQWKPEVLANAKHSGDYISKRLRELTEITSDVIIDAFKQYSGIEDPTEEEIKRVLDAEGSSSGLSDAFNIAVSNRARVGWTTRAHTAADVPVYCYGSKYCDQFKGSIENTELPQLIEDYLKLDINNVSEMIKDFNTNATEILGRDTNDRDVNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDW3</accession>
    <name>I4YDW3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">WALSEDRAFT_60183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957955.1">
        <property type="nucleotide sequence ID" value="XM_006957893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDW3"/>
    <dbReference type="FunCoup" id="I4YDW3">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDW3"/>
    <dbReference type="GeneID" id="18473798"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60183"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDW3"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="425" mass="49121" checksum="DADCAD07BB819EDA" modified="2012-09-05" version="1">MVAYDLTTRLIPFLDRHLALPLLNYLTDLDIYNQNQLQSAQYELVKGTNMVDYASQINPHESQDDKKKHIVDTQQQYQQKAKEVLEVLTNPDVSNHLTQDKHKNREILQEKFNLQPNSIEVLYDYGHFQFSSGNYVEAAEYLYHFRILSTEPAKVLSSQWGILASNILKGSFDQALEDFNGLRETIDRQHSQDKGTVIQLQQRTWLLHWGLFIFFNHEQGRDVLVDLLSHTAYLNTLQTACPWLLRYYTIAVIATSRQSQRQKSLIRDLIRVVNIETYQYQDPLTKFVEALYTDFDFNVVEAQLKEIDTVFTQDFFLSNEQLKDDFFSSARFYVVEAYCRIHSHVTISEIAQKVGLSEDAFKSWISKEEKFVVDSNAVYIPTETPNVLSTILDKSSALALRSQSIKQAITSIHEDIPQTPSEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ4</accession>
    <name>I4YDZ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_45372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957981.1">
        <property type="nucleotide sequence ID" value="XM_006957919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ4"/>
    <dbReference type="FunCoup" id="I4YDZ4">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDZ4"/>
    <dbReference type="GeneID" id="18472361"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45372"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_0_1"/>
    <dbReference type="InParanoid" id="I4YDZ4"/>
    <dbReference type="OMA" id="EWDDWME"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="7">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="24047" checksum="ECEDAB8F5B105C3C" modified="2012-09-05" version="1">MIPTPDLSHLKASDYDKVYEPAEDTFILLDAIEEDVEEIKRNRPNLCYEIGPGSGCVSAFIASILKSSTLYLSSDINPYAASCTRRTGVQNGHTLDVIQASLYDNIRIPRSVDLLLFNPPYVPTEYEESTLAQQNQDISGAWAGGNIGMDLTNKVLENLDNLLSDNGVMYLVAIRQNNPQDICQNLNSSGSFDAKILISRRAGRETLFVIKCARIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE47</accession>
    <name>I4YE47_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_36945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957503.1">
        <property type="nucleotide sequence ID" value="XM_006957441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE47"/>
    <dbReference type="FunCoup" id="I4YE47">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE47"/>
    <dbReference type="GeneID" id="18471988"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36945"/>
    <dbReference type="eggNOG" id="KOG1969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004894_3_2_1"/>
    <dbReference type="InParanoid" id="I4YE47"/>
    <dbReference type="OMA" id="RWLKGWE"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="154"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="680" mass="76425" checksum="94FBF4F9BB2BC93C" modified="2012-09-05" version="1">MTTTTPLEPFQERKHPSIRLAPVHATSTTGQPLTFGRRKKLDGFSGSKGVNKSSSCLETPVHKLITELNSLPSTSSVPTQKVASSDTRLWTDKYRPHKFTDLMGDDRLNRQVMSWLKEWDQCVFGKKTADSLYKRKRDAEPFAYRDPYNLGRPQERVMLISGPPGLGKTTLAYVIAKQAGYRVFEVNASDDRSARTVDEKLKSALDVNPITFDGKIDKRPTLVLIDEIDGATGEGSGGFVRQLINITNDHVPKKRKNGTTQPRLLLRPIICICNDLYAPSLRSLRPISRIVRYKPPSMLSTVTRLKDICGEEEMYADTKSLNALAEASGGDIRNCLNTLQFMKNNEMDIHQAITNNSKDTSRSVPSVMQQVFKLQKSKTASVQPTVQSIIECGEYDKISQSCFEGYLTARVNDSRWERYINAINALTDADIRTGINDDYTPYHLSKFHLQFANINNGHISAAGSKDYEVYLERTNNLEVAKSFKTSLPNELYRCYDLNNLVVELSPLLTQILSVNIKLTNAQVATEADRQTMQRAVDICVDLNLDLKLDKDEDNKPLIRMEPAIDSLTQLFTSSSLSTFSTKQLLSKEINNEKTRRKTAKVKSDKPSLNEKYAVDNLNPVVTVDDATPKDFFGRKVIPTTENSPETTLETAKEPTVAPHYKYFEGFSNAVRKPIKISQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE56</accession>
    <name>I4YE56_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
            <location evidence="1 5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957512.1">
        <property type="nucleotide sequence ID" value="XM_006957450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE56"/>
    <dbReference type="GeneID" id="18474840"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63458"/>
    <dbReference type="eggNOG" id="ENOG502SCA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105134_3_1_1"/>
    <dbReference type="InParanoid" id="I4YE56"/>
    <dbReference type="OMA" id="SANCKQQ"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013986560" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="10822" checksum="D21D13B76FE43693" modified="2012-09-05" version="1">MIAQTIFTAAIVAAASAGWESKTGSCNTGSIQCCDLNKKVQDSTGKNDALISTGDIASQIGVQCDQIPLLIGIAIEDECKNTPVCCEGFDDESLIGLGCNALPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEN3</accession>
    <name>I4YEN3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative U4/U6.U5 tri-snRNP-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_37239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957670.1">
        <property type="nucleotide sequence ID" value="XM_006957608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEN3"/>
    <dbReference type="FunCoup" id="I4YEN3">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEN3"/>
    <dbReference type="GeneID" id="18472005"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37239"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016848_2_1_1"/>
    <dbReference type="InParanoid" id="I4YEN3"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="128"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="52234" checksum="681A2792CBCA3E26" modified="2012-09-05" version="1">MAKRNIESNLYLDTVNRHLLDFDFEKVCSVTLSNKSIYCCLICGKYYQGRSKTSAAYNHSIDEEHHVYLGLDSKQFYILPENYKVDDNSLADILKVLEPSYESGDLDKLDSDLVGQDLNKNDYLVGYIGLNNMSNNDYANVILNMLTHIRPLRNHFLLLNDCKTELLRRYSLFNKRVWNDKLFKSQVSPHEVLQLITKLSANKFNIQNSSDPVEFLTFLLNQLHKDLGGNKKPNSSIIYQLFQGQLRMTSQKIIQLDENEDINKKFIKEDKVTTINTPFLILSCDLPPKPVFNDNENIIPQVSLGDVLKKYDGVTTQEHLGQSRQYKLTKLPKYLLIHFKRFSKNRFTSEYNQTIVNYPISGVDFKDYVDSTENINTVYDLVGNISHEHQATAGDDNNKSKWKCQLKSPMKNDDGSSKWFQLQDLFVEEIDRRLIFLGETYLQVWQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEQ6</accession>
    <name>I4YEQ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF866-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957689.1">
        <property type="nucleotide sequence ID" value="XM_006957627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEQ6"/>
    <dbReference type="FunCoup" id="I4YEQ6">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="GeneID" id="18473726"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60077"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEQ6"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="166" mass="18781" checksum="32306CC228103321" modified="2012-09-05" version="1">MVKLDLQVLIEGENVSNVQPADFNDHQFWLQIKCTMCHEVHPKTIAIIPSEEDQLPNTKEGNTANLVFKCSFCGKSAHAKVENKGASAVNVEDIENHSYKSWLVLECRNLEPIGFEARDDNYICTSSLSDTKFEDVTLDGEWSDYDEKSGESVAIEGYKFRFVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YET3</accession>
    <name>I4YET3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_44950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957715.1">
        <property type="nucleotide sequence ID" value="XM_006957653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YET3"/>
    <dbReference type="FunCoup" id="I4YET3">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YET3"/>
    <dbReference type="GeneID" id="18472349"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44950"/>
    <dbReference type="eggNOG" id="KOG0784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="I4YET3"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="37"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="367" mass="39734" checksum="122D4F2AEFFAAC21" modified="2012-09-05" version="1">MFRNSVSLQAKKLARGYATGTATTTAREPSKFGGIYNVTLIPGDGVGKELTQSVKEVFESLNAPVQWSEYDVSGATNAGEPQFLEAVESIKRNKVGLKGILYTPLEANAHNSWNVAMRQSLDIYASVVHCKSLPGYPTRHSDVDFAIIRENTEGEYSGLEHQSYPGVVESLKVSTVAKAERIARFAFDFAIKNNRKKVTAVHKANIMKLGDGLFLNTCRRVAKEYEGSGITFNDMIVDNTAMQLVAKPQQFDVMVMPNLYGNIVSNIGAALVGGPGIVPGVNIGADYALFEPGCRHVGMDIMNTNKANPAAMLFSASMLLRHLGVSNQADKIASSVYQVVRDGKVRTADMGGNSNTTDFTQAVIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEX2</accession>
    <name>I4YEX2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957187.1">
        <property type="nucleotide sequence ID" value="XM_006957125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEX2"/>
    <dbReference type="GeneID" id="18473561"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59802"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="InParanoid" id="I4YEX2"/>
    <dbReference type="OMA" id="DIWIAGA"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="172"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="260" mass="27987" checksum="8FFDF3B75363188C" modified="2012-09-05" version="1">MDLNLATAGSIAAFSVDMLVYPLDTIKTRYQSAPKGISLLSISYRNLYAGVGPVVAATLPSAAVFFTTYEQLGGLLRKSTSFSAPITQIIASNIAECASCAVLAPAELIKQNAQVENKENTATLTRRLFRRENIRTLLAGYRALVFRNLPFTTVQWPIYEHFKKLFRSKDFSRGQAAGMAAMIAGTAASTATTPVDVVKTRIMIQNQKSGGVWSTTKDVISSDGVKGLFRGGLLRSSWAALGAGVYLGSFEKAKESLGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF10</accession>
    <name>I4YF10_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_27823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957222.1">
        <property type="nucleotide sequence ID" value="XM_006957160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF10"/>
    <dbReference type="FunCoup" id="I4YF10">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF10"/>
    <dbReference type="GeneID" id="18471012"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27823"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_0_1_1"/>
    <dbReference type="InParanoid" id="I4YF10"/>
    <dbReference type="OMA" id="EIQNMHG"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="11718" checksum="85FCDE2A25860FCC" modified="2012-09-05" version="1">MIINAFRRVAGGRQPTTQISRSIRSYTTEQPLAGEARIRQKLTESFKPIRLQVEDVSGGCGSFYAINIASDSFKGLTTVKQHRLVNETLKEDIAGIHGLQLKTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF33</accession>
    <name>I4YF33_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_68038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957245.1">
        <property type="nucleotide sequence ID" value="XM_006957183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF33"/>
    <dbReference type="GeneID" id="18475335"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68038"/>
    <dbReference type="eggNOG" id="ENOG502QZWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_1_0_1"/>
    <dbReference type="InParanoid" id="I4YF33"/>
    <dbReference type="OMA" id="MPWPTIL"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="353" mass="39744" checksum="EC591756B1D254A2" modified="2012-09-05" version="1">MTNLNSHFEVQIYNGWWQPRAFFLDLVGKLKTAQALTQHPFDFVDIHLTTPGSSWQWAVFSMFGVSGIVTLFLVYFTKRYIRGMWTLAFVVFHISFVAYFVMASGLGWTAIEVQFLHGRGTTFGGTRQINYTRFVQQILASPTYVLILLLGAGANVEMMLFGMFTQIYFWVCLLIASLISDQYKWGLFTMAVVLEFNVWAVLLHQGMHMLPLRGSTTKKGVFYGVTGWYILIYLLYIIAVGVSELGNVITVTAEAVFYGVLDLCIQIVMLFVFIPAFSSYIPGVGSRGAAIEGQALDNPSYALPRKEPPQVQQQQPVEQVTQPAQQAHTQEKVQMPQPQHTAQQGQQQQPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF47</accession>
    <name>I4YF47_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_27852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957258.1">
        <property type="nucleotide sequence ID" value="XM_006957196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF47"/>
    <dbReference type="FunCoup" id="I4YF47">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF47"/>
    <dbReference type="GeneID" id="18471013"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27852"/>
    <dbReference type="eggNOG" id="ENOG502SBII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063266_2_1_1"/>
    <dbReference type="InParanoid" id="I4YF47"/>
    <dbReference type="OMA" id="QKYHREW"/>
    <dbReference type="OrthoDB" id="10470373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="6">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="25630" checksum="D3DDE1E0976C740C" modified="2012-09-05" version="1">MARSKMGDDELENKVVEYLRKRNRPYSATDIAANLGQNVSKLATQKVLNVCAERGLITSKTYEFPGKQSVFVANQNDDNDDISPEEKEALIVDNDTLSKECKSLNEQIGHFDNALEINAMKKLPAFNELPALIEQQQKRIIELDLYINESKDLNNMVSSEELAKVDSEFIKWKTLYRKRLRKYKDVRDALCGDEATKEDIMNLDQELGLEELDDDLKDMLKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE5</accession>
    <name>I4YFE5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957351.1">
        <property type="nucleotide sequence ID" value="XM_006957289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE5"/>
    <dbReference type="GeneID" id="18473612"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59894"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004893_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFE5"/>
    <dbReference type="OMA" id="TTPGKFC"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="172"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="804"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="838" mass="94307" checksum="2FA78F162D3E5364" modified="2012-09-05" version="1">MMDPLSLSVNLSPVVLRTLVRHLIKKRNKEDKREVDDPNDEYAFDQTFKLTRAFLDIAMNHPVEDLQNLGSTYVPPPFWVHNVPVTVPMSICNDAAEHLIKAFGGEEPMRAAVGGTRWWQVRPTAGLPAEWICMKSDRKLATRHNKLKVREQPKDPLTPQFFQDIEGLPRTILYVHGGAYYWGSINTHRYLIWRMARKMRGKAFAVSYRLSPQYGFPCALHDVLSAYLYLLYPPEGAPHKAVDPANLIFAGDSAGGGLLLSLLLIIRDLGLPLPAGSIHISPWCDLSHSFPSVLQNYETDVIPKYGFVHKPSTLWPPPSEDLLQRTREHIKSSTLRSTSPLKGLGTAASHKAEKGRRKEETNAAINAEHGRERMDIPREVPTVDINGKTVELKGQIQMYATNEQVGHPYVSPVLAHLGGLCPLFIMASDGELLRDEAIYVAHKAARPDEFEYKEDAKRRLPSMNGIEGRYGPTKVHLQAYDKMCHDLPLFSMVTPAKYAYRAMAAFCFHVTKDKAAQPSPAIKPAHNGMTMSDFELDNPLEMPPTPSSGLASPTKLPEAKSPRRKFSLLGLRNEGAGSSDMSSPVTSNGSQDNAPSSDAERPIKAGPGTAGHIAVYDEATAFKDGNMIRERVSMGGVTRPMEPPEELEYLRMSVNEVGVFKPDAVKRYIEGMESWNTKFKHAAKNVERQREKSLRESHIHAEKMMKENDDIFDIPEVTWRWQWALENEKPPPASIVARRDTQEARRLVELVDKVDNKHASKTVNLWTLIVHLLSPQKSKYGVNDEDEVGPWTRDIEELKKKYQTDEKGEVIPEEVSADEENNFDNKKEAWMKSQVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN4</accession>
    <name>I4YFN4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957432.1">
        <property type="nucleotide sequence ID" value="XM_006957370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFN4"/>
    <dbReference type="GeneID" id="18471392"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31929"/>
    <dbReference type="HOGENOM" id="CLU_2711842_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFN4"/>
    <dbReference type="OrthoDB" id="10538118at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="73" mass="8609" checksum="AFA9BD8B3DB15E6E" modified="2012-09-05" version="1" fragment="single">MALRESWEADSHIGLSFDERLQRDRLRRQAGEDLLRDIQRKRNESNPPPAYSPRVRTPAYAPPLPPRRTVNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN7</accession>
    <name>I4YFN7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_63408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957434.1">
        <property type="nucleotide sequence ID" value="XM_006957372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFN7"/>
    <dbReference type="FunCoup" id="I4YFN7">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFN7"/>
    <dbReference type="GeneID" id="18474839"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63408"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFN7"/>
    <dbReference type="OMA" id="KVAKRCR"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="633" mass="70205" checksum="D5BFAF3868454C84" modified="2012-09-05" version="1">MAAILGSPLPPVEHAISVSLPTWKDHTDYEEGAPRVVDAMVTGYPRFFIHRKIQQLSSIIITKFGNSDSESCLLFPINKWAEMCRDFIIPSAKSARLAHLTVCDPSPDPAIPSIEVHAVIFNKDFFSLAKQFWQHTGLGVSSRLAERALDCLEASEKISPTALSKSPSSLSKSPTLTSPPTFLRTGSRNRYNSNKSKFSQTSQPPTPGGSDLVAGKLSNNALKQADEDNNQDIFDKDHAVYVEERYGRNLPLASAPLAKRALKRRIAGVVIDPHVDAAVGPTIESERGAGLTEDDVWLTSTGMAAIWLTHQAAMTWKGAETGKSVCFGFPYTDTLKVLQKWGPGAHFMGRGDDADLEHLEEIASKEQLLAVFCEFPGNPLLKSPDLARLRELADKYGFLIVVDETIGSFMNIDILPLADVVVSSLTKAFSGETNVMGGSIILNPEGSHYEELRDHIVNIYEDSYWFEDAIFMERNSRDFCNRVKKVNENTETLCDWFYNLSELNGSNEGVIKEVFYPKYTTTENYNARKREGGGYGGLFSLTFGSKNNSKERNGDIARIFFDNLDLAAGPSLGCNFTLASCYAILAHYTELDWIEEYGVDRNLIRCSIGLEDVNTLLSAYKFAYEKALEFVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFP9</accession>
    <name>I4YFP9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_31940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957445.1">
        <property type="nucleotide sequence ID" value="XM_006957383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFP9"/>
    <dbReference type="FunCoup" id="I4YFP9">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="GeneID" id="18471396"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31940"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="InParanoid" id="I4YFP9"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="32573" checksum="B131A63B469CF955" modified="2012-09-05" version="1">MSSQTTNPKPLPGWSMPLAGAVGGVVEILTMYPTDIAKTRMQLEAGKSQGMVKILSDIARKEGFARLYRGLAAPLTMEAPKRAVKFAANDYWGKTYKYMAGTTEMTQALSLATGCTAGATESFVVTPFELIKIRLQDKTSTFKGPLDVIKRTIQSDGLLGMYAGMEATFWRHFWWNGGYFGVIFQIRSHLPKTETNSGKLLNNFTAGTIGGLCGTVLNTPFDVVKSRIQGTVKVPGVVPKYNWTYPSLILVAREEGIKSLFKGFIPKATRLGPGGGILLLVVDFTINQMRKIMGPPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV8</accession>
    <name>I4YFV8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_67742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956901.1">
        <property type="nucleotide sequence ID" value="XM_006956839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFV8"/>
    <dbReference type="FunCoup" id="I4YFV8">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFV8"/>
    <dbReference type="GeneID" id="18475289"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67742"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_4_1"/>
    <dbReference type="InParanoid" id="I4YFV8"/>
    <dbReference type="OMA" id="WIHFAES"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="221" mass="24666" checksum="21AAD120F0C9F042" modified="2012-09-05" version="1">MIKLHHLENSRSVRILWVLEELGIEYELKTYKRLPSGLAPPELKAVDPLGHAPILEDDGHTVAESGAIIEYLVEKYGGGKYTNSDDAFWKHYIEGSLMPFCVFKLVLSKGIESIPWYLRSVLAVVPRAILSQWVDPNLNNAVEIVDKQLKGKQGWAVGGDVDGNPTIADFMLGFTIDVLAFGGRLEHVGEGIKSYAERLQSYPSYKKAIEKSGNYRYKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX3</accession>
    <name>I4YFX3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_59654</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956914.1">
        <property type="nucleotide sequence ID" value="XM_006956852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX3"/>
    <dbReference type="FunCoup" id="I4YFX3">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFX3"/>
    <dbReference type="GeneID" id="18473479"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59654"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFX3"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="234"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="475" mass="52678" checksum="959AC30F3D7ED2B8" modified="2012-09-05" version="1" fragment="single">MRIAILHPDLGIGGAERLIVDAAYSLQSRGHTVDIFTSYHDPNHAFNETKDGTLRVHVLGDWFPRTLWGYLHIVCAIIRQIHLAIMLAISISLSKIIAPSLAFHAWHRPTQRYDVILVDQLSAAIPLLRVWLGIPVVFYCHFPDKLLASGSVAPVSGDGKIVYPARMSKLKQLYRIPMDLYEEFSTADADALIANSEFTSNVIQNTFREVEQTPIVIYPSVDTSDLVGSAGELQSRIFLSINRFEPKKNATLAVEAYAKLVEGLEQSERDSLALVLAGGYDARLPSNVDCVQNLETLCKNHSLSYEFIDDTQSISSKQPKDVYFMLNINTQTKKTLLNSPSTLALLYTPTNEHFGIVPVEAMACGKLVLATNTGGPVESIKDGETGYLLTSDPFKWSQRMKILLLPSNQEKIIASCKARVDELFTLHKAGEKFEQVLGGVVGHGLSNHGERGMLIQGTVFMFLAMTFIIYIVGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG91</accession>
    <name>I4YG91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957024.1">
        <property type="nucleotide sequence ID" value="XM_006956962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG91"/>
    <dbReference type="STRING" id="671144.I4YG91"/>
    <dbReference type="GeneID" id="18475310"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67863"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2279635_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG91"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="A1CC8E455ABC2A9C" modified="2012-09-05" version="1">MVCQQLRHMPGSKNINATTRRISKTSTHSAEEMGRFWQTKHKINVPFAFDRKEAKKRGEGGNIIGAQFKGKVFVLEDVITGGTLIRHSINLIKNTGKRMIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB2</accession>
    <name>I4YGB2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957043.1">
        <property type="nucleotide sequence ID" value="XM_006956981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB2"/>
    <dbReference type="FunCoup" id="I4YGB2">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGB2"/>
    <dbReference type="GeneID" id="18471347"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31655"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="InParanoid" id="I4YGB2"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="161" mass="17713" checksum="97A6B351ED5577F9" modified="2012-09-05" version="1">MTFTFNLLRNIPRASQVGRVQLRGATSQFAAFRGLATKRFTKQHEYVIYDDETNIGTIGITNHAQESLGDVVFVELPAPGSVVKQGEQIGAVESVKAASDIYAPLAGHVEAVNDELSEQPNLLNKSPEEDGWLCKVRVTAPEQFNELLNEETYTSLFAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD7</accession>
    <name>I4YGD7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957066.1">
        <property type="nucleotide sequence ID" value="XM_006957004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD7"/>
    <dbReference type="FunCoup" id="I4YGD7">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGD7"/>
    <dbReference type="GeneID" id="18473526"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59738"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="I4YGD7"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="22127" checksum="C7304FD84C25E12E" modified="2012-09-05" version="1">MESQLALTGKDYTLIVSDTNAAMSIIRMKDDEDKMKQLGEHLVMAYNGEAGDTIQFAEYVERNLRLHSLRHDIELQPKASASWIRRQLADSLRSRKPYAVNLLLGGWDVPKGTPELYWIDYLGTLAHVPYACHGYAAFFATSTFDRYHRPDMSLEEGLELMKRATNEVEKRLIVNPGGWKARIITQDGVREVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH1</accession>
    <name>I4YGH1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_27737</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957096.1">
        <property type="nucleotide sequence ID" value="XM_006957034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH1"/>
    <dbReference type="FunCoup" id="I4YGH1">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGH1"/>
    <dbReference type="GeneID" id="18471008"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27737"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGH1"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="21">
        <location>
            <begin position="36"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="20">
        <location>
            <begin position="156"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="22">
        <location>
            <begin position="574"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="19">
        <location>
            <begin position="1109"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="784"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="917"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM23063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1188" mass="129956" checksum="57C7F38C88738C8C" modified="2012-09-05" version="1">MNPAFASEFRESSSVPSTPGPTSIHDIRQKSGQPLTGKRLLVANRGEIAVRIIRSVHELSMQTVSIYSHEDRLSSHRYKSDEAYQVGAGKPPVSAYLDQDDIVRIAKEHKVDLIHPGYGFLSENAEFARKCAENGITFVGPTPEAIDGLGDKTKARKLAMESNVPVVPGTKGAIDSYDQANAFIEEYGFPVIIKAAMGGGGRGMRVVRSQGEFEEAFGRAVSEAKSAFGDGTVFVERFLDHPRHIEVQLLADSHGNVIHLFERDCSVQRRHQKVVEIAPAPNLSDEVRNSILNDAKTLAKAIGYRNAGTAEFLVDQMGRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIACGASLAQLGLTQDKITKRGSAIQCRITTEDPSVGFAPDTGRIEVYRSAGGNGIRLDASNGYAGAVITPHYDSLLVKVSVRGQSYDLARRKMLRALVEFRIRGVKTNIPFLFRLLTHEVFVAGNTWTTFIDDSPELFKLVTSQNRAQKLLTYLGDVVVNGSSIKGQVGEPGLKSEIVVPKLPSRDGSADAHDTSKPCTSGWRNVILEKGPEGFAKAIRDYKGCLIMDTTWRDAHQSLLATRLRTVDMANIAKETSHALANAYSLECWGGATFDVAMRFLYEDPWQRLRTLRQLVPNIPFQALVRGANGVGYTSYPDNVIYDFSKKAVENGLDIFRVFDSLNYIENMKLGIDAAKKAGGVVEATVCYTGDVASPNEKKYTLEYYVNFVQELVDCGIHVLGIKDMAGLLKPHAATLLIGAIRQRFPELPIHVHSHDTAGISAASMLACAQAGADVVDVAIDSMSGLTSQPSMGAVVSALEQTGLGAGIRHEDIQALNLYWTQCRILYQCFEANVRSSDSGVFDHEMPGGQYTNLMFQAQQLGLGTQWTEIKQKYIEANELCGNIVKVTPSSKVVGDLAQFMVSNQLSKKDVEERADKLDFPNSVIEFFQGYLGQPVGGFPEPLRTKIIRDKPRIDGRPGIGMTPVDLKQVKKDLVQRFGKHITDADVSSYCLYPKVFEEYQNFVEKHGDLSAVPTRVFLAPPQIGEEVNVTIDQGKTLLIKLLAVGALDQQKGVRDVFFELNGEVRAVSILDNSAAVDHVQREKATREPGSVGAPMGGVIIELRVHEGQEVKEGDPLAVISAMKMENSISAPASGKIARVVVHESDSLSAGDLICEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGN0</accession>
    <name>I4YGN0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_50149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956523.1">
        <property type="nucleotide sequence ID" value="XM_006956461.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YGN0">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGN0"/>
    <dbReference type="GeneID" id="18472517"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50149"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000691_1_1_1"/>
    <dbReference type="InParanoid" id="I4YGN0"/>
    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="680"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1786" mass="200922" checksum="AAD22C2FFD8DE784" modified="2012-09-05" version="1">MNGTEVEDKRDRLEINRDNPQIDNNNLESTSIDDPRSSPAASSPPPAQKLAHQSNTSLTSLGVNPSTMLLSSSLDTLANTRDGKKSPLNDAINKAKDSIASEEPDLLTIFEPLRLGCYHKSTLATSVDAISKLVGSSLFRNVDLQGQNNSKSSLADKITMTVCDCYSNNSSLDDQIILQIVKALLAIVLYNNPTGLIHHSTLLSAIRTVHDIFKYSKDQGNQMIAQAGLTQMVNAVFSRLRTAYPAHSQSSSTRGTPSINTQAMAEPTLSIQDEHSKSLEEEVTHEDTHESLDDELAEQEVDEDGKPSLPTETEQMTLSTFEGRRSFDATPANQSTDPLNAPDEEISDEELLTKDAFLVFRALCKLNMKSLHKDSEKEIHSPEFRSRLLSLHLIKTILNTHISVLLDKRIILHSSSNNEPTQLFDAVKQYLCLSLSRNAPSAIPQLFELCCQIFSRVLESMRMRMKREIEVILREIFLPILELKENSSNKQKTILCSTILKKLCQNPQAIVELYLNYDCDKNSLENIYEHLMNALSKIASAHLPPGPKEASGTSTTEALTSFFRPSKNELPPSLNTDSLMPAPDANLLAATFSNQAAVQAHILDVAVKRQALDLIRSVLASLVSWAERGALPVATVAEENHQSVEGSPVVGVAEYSSGHSTPEISNAFDFSNVNSDDPTQFESAKARKNILIEGIKRFNYKPKRGVAFLLEHGFIKSSEPKDIARFLLTTDGLNKAQIGEYLGEGEEENIAIMHAFVDAMNFNEMSFVTALRAFLQAFRLPGESQKIDRYMLKFAERYVQHNPSTLFANADTAYVMAYSVILLNTDAYNPQNKRRMTKEEFIKNNRGINDGSDLPEDYLIGVYDDIHSDEIRMKDEMYLQNAPPPPNSNIVNVLSGADRNYQKQQNNIRSEGMANKTEALFKSMLRAQRRSGMKNSETYFSASHYEHVKPMFEVAWMAILSAMSGPLQESDDNEIVLLCLQGFANAIKISCLFDLELERNAFVTMLAKFTHLNNLAEMKPKHVDAVKVILEVAMHEGNYLKGSWKEILGCVSQLERFHLISNGVDLSSETGNIGGRQRSGSTTRKSSTVPRHLVPDESIAADGRALQVTGRGDMVFSATQMLTGDAMVDFSQALAEVSWAEIQQSGKQQHPRLFSLQKLVDICYYNMNRIRLEWSKIWLILGDHFNKVCCHPNPSVSFFAIDALRQLAMRFLEKEELAHFKFQKDFLKPFEHTMIHNPNLDAKDIVLRCLQQMLQARSVNIRSGWRTLFAVFSAAAKSSNERIVSHAFDIVNSIEKEHLGYLIKYGSFSDLAVCITDFCKVPYQRVSLQAMELLRSSINSMLVAPECPLSRGEVGVVQSQDNQQQPPVDDPMVRFWFPILFSFYDIIMNGEDLEVRNIALDSLFATLKIHGSSFRVDFWDTVCQKVLFPIFSVLKSPVDLSRFNTHEDMTVWLSTTMVQALRNLVDLYSHYFEILESKLEGLLELLRACICQENDTLARIGSSCLQSLIESNAEKISDERWETLTSVFTTLFQNTLASELFNESLRQDLDSAEQTPADPSQSGFVLPLPLTSTTIEEGTVLRSNERRTLFKQIITKCVLQLLLIDAVRELLFNDKVYLAIPPQQLLRFVHLLDESYRFANAFNNNQDLRMGLWKVGFMKQLPNLLKQESSSASTLITLLIKMYKDTRQQHVDRREDISEALIPFGLSVIDGFNELDFETKHRNIAAWTPVVAEIISGVCFFEDEDFEKYLSTVYKPITDILTKDMGSEVRESLCKFFTRVGKMKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGU6</accession>
    <name>I4YGU6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_67493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956582.1">
        <property type="nucleotide sequence ID" value="XM_006956520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGU6"/>
    <dbReference type="FunCoup" id="I4YGU6">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGU6"/>
    <dbReference type="GeneID" id="18475259"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67493"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="I4YGU6"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="331" mass="37050" checksum="1A9839B56F4D942E" modified="2012-09-05" version="1">MSKSANYEVPWVEKYRPRVLSDIVGNQDTVKRLEVIAQDGNMPHMIMSGTPGIGKTTAVLALAHTLLGPDVFKEAVLELNASDERGIDVVRNRIKSFAQKKIALPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFAFACNQSNKIIEPIQSRCAILRFSKLRDIELLQRLRQIAEKENADVTDEGYEALIFTSEGDMRQAVNNLQSTHTGLGLVTPDAVFKVCDQPHPLLVQNLLESCHKADIEDALSKLDELWTHGYAAIDIIQTLFRVARNTQSLEESLKLEYIKEIGWTHMRILEGVATIVQLSGLVARLCKMSIDPKVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHD6</accession>
    <name>I4YHD6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_59582</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956759.1">
        <property type="nucleotide sequence ID" value="XM_006956697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHD6"/>
    <dbReference type="FunCoup" id="I4YHD6">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHD6"/>
    <dbReference type="GeneID" id="18473436"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59582"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="I4YHD6"/>
    <dbReference type="OMA" id="GTCINWG"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="30"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="387"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="68"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="499" mass="54492" checksum="A7DA502F55D75FD9" modified="2012-09-05" version="1">MSYLRSATRNLHTTIKREMPPVNKPSEGLYDIVVIGGGSGGLGAARRSAQYGAKAAIIEAQPKLGGTCVNVGCVPKKIMWHAADLAHHINHARYYELSKDVSDAYTPHKPRFNWADFKKKRDAYIERLNGIYDRNVAKDGVEYHHGWGSISNKDGTSVKVARDDGTTYEIPTKNVVVAVGGRPRIPTEIPGAELGITSDGFFDLEEQPRRVAVVGAGYIAIELAGIFNSLGSETSLLIRQDKVLRNFDTIIQDTVTNEAERQGVDIKKHTNVTKVEKTSDGLLVHLDNGEPLTVDCLLWAVGRVPETEGAGAKIAGIQTDERDHIKVDKYQAAQLADNKYSKNIYAIGDVQGKAELTPVALAAGRRLGNRLYGPSQFKDDHLDYNTIPSVIFSHPPAGSVGLSETDARKQFGDDVKIYTSKFTNMYNSMFPQEEKEPSAFKLIVVGENEKVVGLHLVGQGSDEMLQGFAVAIKMGATKKDFDNTVAIHPTAAEEVVTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF1</accession>
    <name>I4YHF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_31481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956773.1">
        <property type="nucleotide sequence ID" value="XM_006956711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF1"/>
    <dbReference type="FunCoup" id="I4YHF1">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHF1"/>
    <dbReference type="GeneID" id="18471311"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31481"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005230_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHF1"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="849" mass="96657" checksum="15A123CEA9CA9552" modified="2012-09-05" version="1">MEMPPALFRSEDMSLVQFYVPTEIAHDSVLHLGDLGLVQFRDLNPDLNPFQRSFTNEIRRIDEMERRLRFFIGQIYRDNVKIREIESQLDFDLDQSIELDRPHHGPQLIDDIDDKLIDHEGRLTQLNKSFEKLSVDCYKLEEARQALKETASFFNNVNGYRDEIRSSFDDVSMHDDSRPLLDNDNQSETSHFANFELDFVVGTIDRSKLATFERILWRVLRGNLYMNHTDMQEITLPYGASSEENPKKSVFIIFADGQELLNKIRKVGEGMGAATFPVSSNSERRTEALSGLNQQIEDIHTVLYHTAQSRRSELAAIATDVATWSSIVRKEKTVYATLNLFHYDDRHRTLLAEGWVPSHEIIAVQQALRRASSNVGSNVPPIVDEIKAKRMPPTYHRTNKFTQGFQNIVDAYGIATYQEVNPGLYTIITFPFLFAVMFGDIGHGILVFLTALGMVYFEKKLMKKKLDEMTETIFGGRYIILLMGAFSIYTGLLYNDMFSRSLHIFTSSFEFPAPSPDQGSVIAEKVRDPYIFGLDPAWHGSENSLVFTNSMKMKMSIVIGVIHMSFAICLNIPNYLREKKPQYILAEWLPQILFLNSIFGYLVLCIIIKWCTDWNNSSNGPPGLLNMLIYMFLSPGKLDPKDQLFKGQGFIQLVLLLVAFVCVPWMLVAKPYLEWKEHQRTKGAGYGTVVNDDHRLSLDEDAGHDLRSSAASESGDVDGHDEHEFELGDVAIHQIIHTIEFVLGCISNTASYLRLWALSLAHAQLSEVLWNMILEPALDSSGLTGIIALALSGTFWFILTVAILCMMEGMSAFLHALRLHWVEANGKHYKAEGYAFEPLKFEPIDLENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHJ8</accession>
    <name>I4YHJ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_35956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956814.1">
        <property type="nucleotide sequence ID" value="XM_006956752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHJ8"/>
    <dbReference type="FunCoup" id="I4YHJ8">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHJ8"/>
    <dbReference type="GeneID" id="18471937"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35956"/>
    <dbReference type="eggNOG" id="ENOG502RXRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107213_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHJ8"/>
    <dbReference type="OMA" id="KYWQNEP"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="17131" checksum="660CD787E5B95C51" modified="2012-09-05" version="1">MLPHNTCSIIQNASRAAIPKVPLQYTNQNFHLSRLLLDQGFITNVTLGSPSSNNPSTFLPTDEQHRRIWIELKYRSNRPVLNNMSVISKPSKRVWMEKDEVKRWVNGARIKGVSGLKLGEVGYLKTHGYGWLEARDAARRNLSGQAMVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL1</accession>
    <name>I4YHL1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956825.1">
        <property type="nucleotide sequence ID" value="XM_006956763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL1"/>
    <dbReference type="FunCoup" id="I4YHL1">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHL1"/>
    <dbReference type="GeneID" id="18473457"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59618"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="InParanoid" id="I4YHL1"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68331" checksum="1988B5B1327806AB" modified="2012-09-05" version="1">MPSKFAERLSNWNETVNDRIADSWFGRYFRLDGSGHKKARAGAKFTQEIRAGITTFVAMAYIISVNSNVLQSCGGTCRCDHYEGGCEDPDYLDCTREFRRDIITATSAISCIGSFLMGVMANLPVAIGPALGPNAYFANTVVGINNSGRTNYETALGAVFLEGVIFVVLAMFGVRAWLARLVPRSVALAAGAGIGFFVAFTGLSPSGLNVLGKHPSNIIGLSGCPDGAMECPDAQIMRSPTMWLGIFCGGVITVYLMLYRVKGAIFFGIILVSIISWPRPTPVTTFPYTDEGNQDFDFFKKVVTFRPIKQSAGVLNFDYSDGHTWIALISFLYVDLLDATGTLYSMARFSGVMNERTLDFENSTMAYTADGLSILIGSTMGSSPAVTFIESAAGIAEGGRTGITAITCSFLFFISIFFGPIFASFPAWATGSTLVIVGSLMAKNIVDINWGYLGDAIPAFLTVIMMPLSYNIAYGLIAGILSYVVINTIPAIIRKLTKNKISPPDYDRKDVYWDTQRAYFVPPWMRRLAKGDKKFWKGDEHDDESYYDDEYEHEMEAESITSSMRRERLRSSAGTSRFDEKSFVDDDDSEDNHKPHQNVHSIPLESPNIQTIENEVHYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL9</accession>
    <name>I4YHL9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_43599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956832.1">
        <property type="nucleotide sequence ID" value="XM_006956770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL9"/>
    <dbReference type="STRING" id="671144.I4YHL9"/>
    <dbReference type="GeneID" id="18472297"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43599"/>
    <dbReference type="eggNOG" id="KOG4115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113002_1_1_1"/>
    <dbReference type="InParanoid" id="I4YHL9"/>
    <dbReference type="OMA" id="DDIRFMR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="116" mass="12967" checksum="38F55E8523F1E99E" modified="2012-09-05" version="1">MAVADQKAFYRTVMAESAEGLRRLQDCKPVKGTLILDRADARIIESQGNIFEGDQGKKYARACRNIITAITDNLNDIDQSESEDIKLIRVRNKKHEIILTSNGNYLLICVQDPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHR0</accession>
    <name>I4YHR0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_14707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956138.1">
        <property type="nucleotide sequence ID" value="XM_006956076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHR0"/>
    <dbReference type="FunCoup" id="I4YHR0">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHR0"/>
    <dbReference type="GeneID" id="18470640"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14707"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="I4YHR0"/>
    <dbReference type="OMA" id="VCKGLIY"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF6">
        <property type="entry name" value="MAP KINASE KINASE MKK1_SSP32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="407" mass="45823" checksum="36225610F754AF90" modified="2012-09-05" version="1">MDNQQKPSLSLAIPSDTSSSSAPSSSTVDNDRTVYVSGRTPSAPPRPPKPQDLDLSNSDIQESDLIIIDKLGEGAGGSVVKVKHKSSGLIMAKKSMSTSPDPAIHKQLLRELQFLKQCQHETIIKYYGAFLTNENTEVDVCMEYAEGGSLDRIYKHIRRRQGRTGEKPLGNIAGSVLRGLEYLHSMKIIHRDIKPSNIVITRNGQVKLCDFGVSGVLEGSVAETFTGTQFYMAPERMDAKGQGYRVNSDVWSLGLTLLEVALNRYPYQEVNEEPVGPIELINMITLSKPPELSDEPEIGLKWSSGIKGFIKKCLDRDPSTRPSPSELLQDNWVKKTCYKFPADRLSVWLAQVWEWEMPSIPRQAKPIKRRQPLPHQIQQPVRQQQPHKVQSQQQQQQQQTFYNLNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU4</accession>
    <name>I4YHU4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956213.1">
        <property type="nucleotide sequence ID" value="XM_006956151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHU4"/>
    <dbReference type="STRING" id="671144.I4YHU4"/>
    <dbReference type="GeneID" id="18475220"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67192"/>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097960_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHU4"/>
    <dbReference type="OMA" id="RACCREL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="25155" checksum="CB22C9F09FDA8982" modified="2012-09-05" version="1">MIPLRSSSHKALSGDYDSSSRRYDENEFYAKPPIRALKQRLVRDANRFVGQQRINCLLEGGWFKNAKESRNRLGAYKFLRLSPNRRHLHYLDTSESYEISQGFDNLPDFIDLDTITTIQSKLGTSTTSVASTVNSLTLLSKQGVIAELIPLSPSQYSEWYDGLRYVLDESSSLTGQSNDLVNTLTDLGVKIKLLDLAGENVDIPNNIPTPMPPRDTQFFFADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHV7</accession>
    <name>I4YHV7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cation-transporting ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_14923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956143.1">
        <property type="nucleotide sequence ID" value="XM_006956081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHV7"/>
    <dbReference type="FunCoup" id="I4YHV7">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHV7"/>
    <dbReference type="GeneID" id="18470645"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14923"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="InParanoid" id="I4YHV7"/>
    <dbReference type="OMA" id="WYYSLFN"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="244"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1202" mass="134679" checksum="AFA12E862C425E69" modified="2012-09-05" version="1">MTHKISSQSISSISLHNSLPLFFRIYFIWFGFYPFLINAYYFEYDKYLQSEEYTFMACLFVFGGQALSWLGGRWGMGWRTLTECTNARSLQTASLVRVNPIEHRGEAELVKLDNKAGVYSFIYQSDKYVFNGEEFTRLPFPCDTKPQLKSFKHSAGLSSGDVDTLVEKYGKNIYNIPVPTFMSLFAEHAVAPFFVFQMFCVALWCMDEYFWYSLFTGFMLVVFECTVVWQRLRTLNEFRTMSITPYTMPVYRNGNWSDLISDELVPGDIVSIDRTGENLALPCDLLMLRGSAIVNEAMLSGESTPLLKESIEARGDEEVSDVDGNDRNLHVLFGGTKVLQTNPPSPEDVAAHDGLLTPDGKALAIVLKTGFGTSQGQLIRTMLFSSEKVSANNFESFLFIGFLLIFAIAASAYVWIKGNERGLKKSKLILDCILIITSVVPPELPMELSLAVNASLVALSKFAIFCTEPFRIPFAGRVDVCCFDKTGTITGEDLVVEGVAGIASNPRDLMPLQVTPKETTLTLASSHALVLLDEGDVVGDPMEKTTLEALDWKLGKGDTVAPANKTSKHKHIINIRRKFQFSSALKRMSTVSNIVDGQGQKRTFVSVKGAPETIKNMLKDLPEGYEETYKWFTRKGSRVLALAWKDIKANNTEIPNLHRNDVESDLHFAGFLVFHCPLKPDAVATLKMLNDSSHRCIMITGDNPLTALHVANDVEIVDRDALILDVAEDAKDETDLVFRSVDEKTIIPIDPTKPIDKTILRDHDICMTGAALRQIEKNTENWHALIQHTWVYARVSPTQKETILTTFKTLGYTTLMAGDGTNDVGALKQARIGVALLQGTEDDLRKIAEHAKIERFKKVYEQQLKFSQRFNQPPPPVPKAIAHLYPDMVEAQRTAAAQHSVSRQTQTQPQQFNMSAITEKMADMEDDNEPPQIKLGDASCAAPFTSKLSNVSAIANIIRQGRCTLVATTQMYKILALNCLITAYTLSVQYLDGIKAGDYQLTISGMLMSVCFLCISKAKPIEKLSKERPLTNIFNFYILLSVLLQFAIHIFFMVYITDLSNTLEDRGPIDLDAEFKPSLLNTAIYLLGLSQQVSTFAINYQGRPFRESLRENPPLMYGLMGASAVSFCGATDFLPELNRWLQIVEMSYGFQFKLCGSMILDFVLCYAVEIGCKNLFANLNPPELVTRGSERREKRRENKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY6</accession>
    <name>I4YHY6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_31078</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956252.1">
        <property type="nucleotide sequence ID" value="XM_006956190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY6"/>
    <dbReference type="FunCoup" id="I4YHY6">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHY6"/>
    <dbReference type="GeneID" id="18471244"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31078"/>
    <dbReference type="eggNOG" id="ENOG502QQBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="InParanoid" id="I4YHY6"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="52"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="241"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="390" mass="43250" checksum="D68B77AA7D6AC2AA" modified="2012-09-05" version="1">MIARQALRAASRQTRAISTINRAAPAVAQRVAIPAATRGIKDIVFAKEGGVERVYERSDYQGSKLQEILGNETLAMIGYGSQGHGQALNARDQGIKVIVGVRKDGQSWKEAIEDGFVPGESLFPIEEAIDRGTIIMNLLSDAAQSQTWKDIAPLIKPGKTLYFSHGFSVVYKEDTGVIPPKDVDVILVAPKGSGRTVRTLFKEGRGINSSIAVFQDVTGKAFEKAKALGIAVGSGYLYETTFEKEVYSDLYGERGVLMGGIQGMFLAQYEVLRKNGHSPSEAFNETVEEATQSLFPLIGKYGMDYMYNACSTTARRGALDWAPRFYEANKPVFEALYESVRDGTETRRSLEFNGRSTYREDLQKELEIINNQEVWRAGKEVRKLRPDYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI15</accession>
    <name>I4YI15_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_62276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956278.1">
        <property type="nucleotide sequence ID" value="XM_006956216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI15"/>
    <dbReference type="FunCoup" id="I4YI15">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI15"/>
    <dbReference type="GeneID" id="18474733"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62276"/>
    <dbReference type="eggNOG" id="KOG0346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_17_1_1"/>
    <dbReference type="InParanoid" id="I4YI15"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="605" mass="68637" checksum="B50396692A3B6C97" modified="2012-09-05" version="1">MSDIRESEESFAKFDHLLDKRLLRALADLGFARPTLVQAKAVPLALNGKDILARAKTGSGKTLAYLLPIAQKVLAEKDDGDSKPETRALILVPTRELSEQVSSHLKSLLKYSQKEVSQVNLAGSGTDNKFQRLLLSDKPDIVISTPSRLIGHLQSKSLSLSTLKTLAIDEADLILSYGHADDVKALLSGGYLPKIYQSFLMSATMTQDVEKLRGMVLRNPAILTLEDNEDDSSNLKQYYVKCPENDKYLLTYVLLKLKLIKGKVIMFVNNVERGFKLRLFLEAFGIRAVVLNRELPINSRFHIVQEFNKGVYDYMIATDEAGAFDQEEEEEESESESDGNSSSEDEDEDVDKEIEEVLSSAGEEDVPEVEIPAAESKKRKRKDKGKQKEQDNKKTKMSKKGEKEFGISRGIDFVDVACVINFDLPKNSSSYTHRVGRTARAGRSGISLTFVVNGETKKSKRNEEKIWKKISKRQERRGGSQNWEFDWKQVEGFKYRVNDALKMVTPNAVKEARVKELKNEILNNDKLKAHFEDNPVDYEFLKHDKPLHPMRQQSHLKHVPGYLMPRIAGVKQPHQLELNPDKIGFKKRSNNKKKKSDPLKKFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI19</accession>
    <name>I4YI19_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_62280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956282.1">
        <property type="nucleotide sequence ID" value="XM_006956220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI19"/>
    <dbReference type="STRING" id="671144.I4YI19"/>
    <dbReference type="GeneID" id="18474734"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62280"/>
    <dbReference type="eggNOG" id="ENOG502S24A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461666_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI19"/>
    <dbReference type="OMA" id="SKPCTYT"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="591" mass="66040" checksum="B3E4E2257A505FF9" modified="2012-09-05" version="1">MDIHTKKRKRLTKACDNCHKNKRRCDGFLPCSNCDFSGKQCSYSDNNGHAIPPPKSRSEKEHESHLKLKTEYNLFTSDSHGENSRALLNDPILKKELVILFLDHMYPFNLMFHKPSLLYALEKDRLSPMLLNSIFGLSARLSPHPKFQQIEAWRTGVDFAAIARRILLVPNELGSCALDEPKLEVIQTAVLLAAHDFGVGFFNRAYTYLGMAISQLKTLGLNHDDFVLPAPEDTREKWIGREERRRTAWCVIMLDSIAAAINGRAKPFEEHDLKVFLPADDVAFELAVGNTSNREFINSTPSNDQSTTEFGYLIRIVNIFSNVMGYIYFHEKERMANSSDRSTMSSKTNTESPYSSQACKHALAQWSQSLPHHLELSSINLNLAVMSMQAGANSSGWCYALMHAFAECSVFYLHSTAESNTTEEAVRSSADRQNQSVGNMRAIIDALTITGRKSPLLIYFVYVISKWQLHVQGALDASIADIWDDEIADLWHIDKSILTGGNPPPVLEEVASEDSDNIEEQPAPANTMDTIANILENATNTTVNLNTSVNPLDLDLLPSRDTFLSPSFPDIFVPPINGSEQDKPTLGLGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA4</accession>
    <name>I4YIA4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_67321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956362.1">
        <property type="nucleotide sequence ID" value="XM_006956300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA4"/>
    <dbReference type="FunCoup" id="I4YIA4">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIA4"/>
    <dbReference type="GeneID" id="18475240"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67321"/>
    <dbReference type="HOGENOM" id="CLU_110781_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIA4"/>
    <dbReference type="OMA" id="MKANFEW"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="117" mass="13291" checksum="E9C90D3E6BCE8A91" modified="2012-09-05" version="1">MNSANNVQFNEEEKREPIYTDNQLKNNRELFVIRSTLSMFLGGVAGVLGLTNLYGLIFYLLLAPSLPLLIITLKTQSTQYQSYYKDGLSEIVIPTSDSLFGFILVWTMAYGLVHLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I4YID9</accession>
    <name>I4YID9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Myosin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_59367</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956396.1">
        <property type="nucleotide sequence ID" value="XM_006956334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YID9"/>
    <dbReference type="FunCoup" id="I4YID9">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YID9"/>
    <dbReference type="GeneID" id="18473317"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59367"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="InParanoid" id="I4YID9"/>
    <dbReference type="OMA" id="PPEEYQM"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="1"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="20">
        <location>
            <begin position="733"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="1019"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="919"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1074"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1078"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM23731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125456" checksum="CE1AC856B288CD1A" modified="2012-09-05" version="1">MTLLTTISNDSINDNLKKRFQVGEIYTYIGHVLISINPFRDLGIYTDQILRSYKGKNRLEMTPHVYAIAESMYYNMSAYRENQCVIISGESGAGKTEAAKRIMQYIAEVSGGQDSSIQGIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIMFNHAGEPVGARITNYLLEKGRVVGQITDERDFHIFYQLTKGASQAQRQAFGLQGPDAYLYTSRAGCLDVGGINDVHDFSETINAMNTIGLCGDEQNEIFRMLASILWLGNIVFVENDDGNAQPDDSDTLDFIAYLLQVSRPSLEKAVTCRVMETQRGGRRGSVYEVPLNPAQATSVRDAFSKAIYNNLFEWIVDRINRSLAPTQASDYVIGILDIYGFEIFEDNSFEQLCINYVNEKLQQIFIELTLKKEQEEYSMEQIQWQPIKFFNNKIVCDLIEEKRPPGIFAALNDACATAHADPAAADNSFSQRLNMVSSNPHFNLRGSKFIIKHYAGDVTYNIQQMTDKNKDALLKDLLNLIDESSNPFLQGLFPERPDPNSKKRPPTAGDRIKVSANLLVDKLMASQPSYIRTIKPNQNRSSSEYDDAAILHQIKYLGLQENIRVRRAGFAYRNTFEKMIERFYLLSPSTSYAGDYIWQGDARSGCAQMLTDTGIAKDEWQLGITKAFIKNPETLFALETMRDKYWHNMASRIQRSWRAYLRRRQESAQKIQRFWMSKKEGIAYEKIRTYGHQLLANRKERRRFSLVSQRRFMGDYLDVNGDSPTGQMLSRVCGISKAEPVSFSSRAEILVSRLGRTSKPSPRFVVLTNKALYIVVTTKEGTNVERKILVGAIKGASLSNLQDDFVVLNLGPTEEGDPILVVKFKTEFVTQINRIAGGTVTVNAGPTIDYTKKKDKRAQIKAVKGDISASKPQERINGATYKSHTITIAGGEPASSVSRPPVPRKPRPAKLAAKRGAPRSTAAPRSVPLPGGGGKPALNTPVPTPAARTTPPVPSVHASNPVVAPRAVPPAPAAPPAPVRPARPPSPEKEMWKSIHQFDTQESGELPLEKDEEVEVLNQDASGWWLVKNGSGVEGWCPSTYLNKVPPKPKQPAAPQPPVQRSIPAPPAPVPAPSNEGQASSCSKTKTKTSLKRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ6</accession>
    <name>I4YIJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1365-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956451.1">
        <property type="nucleotide sequence ID" value="XM_006956389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ6"/>
    <dbReference type="GeneID" id="18473339"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59412"/>
    <dbReference type="eggNOG" id="ENOG502S3VD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533405_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIJ6"/>
    <dbReference type="OMA" id="FRESRRM"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698198" description="DUF1365-domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="59956" checksum="8AAA0E261D9227C9" modified="2012-09-05" version="1">MIETMAILLSLLAVTSFFLDFSPMQKAYYVHYRAPHRRMHPFKGTFEPRFYHSLIKLSKESNAGRLLRESSNRFSTLFRIVPTDYLTNQYSKNMSIYDNLIQTLKDRGFDTGKRAKTIYFSTLPLVFLEGSSINNISHYYCYNDKDEIEIVLWEVHNSSGDRHIYILDHRSDQVSRKSISSEYTYCATVPRSFYISAVDNRKGFYRFSYTLPIHKTEEGTKEIQSPRSKVTLFDERMQALTTTRLIPESEPIPITFQSTIAMIFKRPLQDLSILLTLLRQVYFITIVQKVRINRNVPQGITLNRKHGMPTQSSNEAGVLGWTDEDMLASHARRVFEKALARALNESHRDLKVVIKYTDKHIPGTHLETPESKTELTLLVRSWEFYKQIIVAPNADYIYNVLMERCEDLVRASDGRRFYELLRDLKTDSHSWMYTRIREWFVKLTCIKDSENNSKVNFSLSVNKNYLDDSWKTIFVAFCIFLEYKVLQLFYLIVGITPAETQVPWRPIKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM9</accession>
    <name>I4YIM9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Wsmco2</name>
        <name evidence="11" type="ORF">WALSEDRAFT_59433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956484.1">
        <property type="nucleotide sequence ID" value="XM_006956422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM9"/>
    <dbReference type="FunCoup" id="I4YIM9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIM9"/>
    <dbReference type="GeneID" id="18473353"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59433"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="InParanoid" id="I4YIM9"/>
    <dbReference type="OMA" id="AYWYHAH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698202" evidence="7">
        <location>
            <begin position="18"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="241"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="479"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="633" mass="70721" checksum="4A18736DDEDDE03F" modified="2012-09-05" version="1">MLLKGALLALFNKEVLAGVLDDLIGNSHQDISSYNHKFTLNVTEVLTTLDGGKLRNMFAINGKPFYGAQPLVIDEDDVVEIEYINNASSNTTLHAHGIVQQGTMYSDGVPGVSQIPIQPGQNFTYKWKASDQYGLYWLHSHYKDVYQDGQALPLYIRPKNGREKPFNLLTKDDTELASLENQDKDPQIIMISEYASINGTHEIDLSESWNSELLCYDSILINSSGRKNCPSMDKLKSYADENMNALIASDFVTAKGCPDVVKSTPAVSDDTILDPDLWYNCEETNTDVPKFEFDYVQGSDGEQWGVFHMVSASSKWSYIVSIDEHPVYLYSQDGNYHKPMQADAFELVIGESIGIGFKLHTPGEYTMRISNLDMPQILGTHAIIRYGMEGDAKYEVQYEKEEGLPALPKSKPTINYGGGIIDKDATFVQSTHLKNFDAPDVPLKNMAADKTLIMTIQYDGTLYWGLSDNGTEVQRYDMSKMDADTPALFNLERYINSASSTAHYHAHSVVDVVFIVNGTSPQPPHPMHFHGLHRFLLAVGTGPWDYSDVGEFDEKNPGVINWDDPAYLHTFNTAPSTPDAPSYLVTRFHAGAAEPTLLHCHVGSHKAQGMEYLLIAEGEQQDIPDYYRMKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIW0</accession>
    <name>I4YIW0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransferase ChoActase/COT/CPT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955744.1">
        <property type="nucleotide sequence ID" value="XM_006955682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIW0"/>
    <dbReference type="STRING" id="671144.I4YIW0"/>
    <dbReference type="GeneID" id="18473115"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58999"/>
    <dbReference type="eggNOG" id="KOG3716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_0_1"/>
    <dbReference type="InParanoid" id="I4YIW0"/>
    <dbReference type="OMA" id="FIKQQKC"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="611" mass="69685" checksum="874E896ED397F3AD" modified="2012-09-05" version="1">MSRLAPRLPIPGLESSLEKYLKSLEPFIEDDNHTRLHLRTLADDFREGLGKKLQARLKDVEKASPTNWLDDRWWIKVAYHTDRSPLLINSNWWLLYKDDPSIPDSVKKNKNERGFTNWQILRAAWLTRGLLHIKSVLDNGEQLPDLSKAARWFGPRANRLFGMTRIPQYDCDELTHVPLPNLTKHIVVFAKSQTFKVDVIDSKGAIQGWENIAKSFQSITDNLGNNLDADVGVMTSDDRDRWTKNREHLKLLSQQNETNLALIESALFAVCLDDYTLPPRRKEHDELDGHMVNIAGGINGNNRWFDKSMSLIVENNGRAGMNGEHSFVEALVPSIVADYTLYENLPKKDSLDIPQKACDFERLRWVLDGALVREAEGANERAKRLLDDSEPSELLFDEYGIDWMKNVAGLAPDAFIQMALQLTWFRNQGYATATYETASTRIFDNGRTETLRTLTSESKRFVESMMSKDVDSDVRYENLLEATKVHSRSMREASTGKAFDRHLLGLRLLLRPGEGHEFFNNKYFKLSSEWKLSTSGLSAGPRFNGTGFGAVYPDGYGINYMAGPHELKFGIESKVSCPKTSTYDFKKDLLKSLREMRAVCESRQTHLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX8</accession>
    <name>I4YIX8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955761.1">
        <property type="nucleotide sequence ID" value="XM_006955699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX8"/>
    <dbReference type="FunCoup" id="I4YIX8">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIX8"/>
    <dbReference type="GeneID" id="18473122"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59009"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018320_2_1_1"/>
    <dbReference type="InParanoid" id="I4YIX8"/>
    <dbReference type="OMA" id="ERCLYHS"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="559" mass="64783" checksum="665049D12645E670" modified="2012-09-05" version="1">METTAEIKQRLRQSTRDCTERGLIFASIWSAEMASCIKTPIESKSASGFLTSTPARSNVGDTSFNPRNLSFDPDEDLNDEDDAYELAKSYYNSREFERCASVLSSCKSDKSVFLNLYARYLDSERRIQEATEPVMGPTDTRRENTNAEIPQLLSHLKEPKDAFLLYLKGILLHRSSKRIEAMDVLIKSLNAYPWNWSAWLMLGVCIQDIDDLNTVEGYLPQGVMLRLFSVHMLIELHAVTEKLHNALDELDEIFPNSTHCQSQRAFVYYNMHQMEEAETVFDKLYERDPHRTQDLDLYSNIIYVMGNQTKLAALAHAVVKHNRSDPQVCCLIGNYFSIRGEHEKAIMYFRRALRLDRAYLSAWTLMGHEYIELKNSHAAVEAYRRAIDANAKDYRAWYGLAQAYELLGMYNYSLYFYQRATALRPYDQRMWHALSSNYEYLKRFDDAIKCQQRYMELTTEGVDPKMHIKLSKLYKEAHKEQESSLELRKVYDMVESSGGELRVTDFINVYRELAIWELNQGNTALAQSYLMKVVETNAPEREEAMAILRSIQVKELGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIY2</accession>
    <name>I4YIY2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1692-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_13971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955659.1">
        <property type="nucleotide sequence ID" value="XM_006955597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIY2"/>
    <dbReference type="FunCoup" id="I4YIY2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIY2"/>
    <dbReference type="GeneID" id="18470623"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13971"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_2_0_1"/>
    <dbReference type="InParanoid" id="I4YIY2"/>
    <dbReference type="OMA" id="MTNHYLR"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="161"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="396" mass="44559" checksum="96EBA4242AE0DEB7" modified="2012-09-05" version="1">MSSVMSMPPLREFDAFPKTQASYKIRSKQGGIATVIVIFALVLLVFHEIGDWLYGHNEYQFSVDTTTETEMQLNVDLTVAMPCHYLNVDIRDAVGDRLKLSDSIQKDGTTFEPEKYRQIGSAKQSTLSRIVKDSKKGRKWFRPTSTRNRFPKTKKLIKDGPACRIYGSVETKKVNGNMHITTLGHGYSSLEHTDHKLMNLSHTIDEFSFGQHFPYISQPLDKSVEITDNHFPVYQYFMHVVPTTYVDASGHSLSTNQYSAREDIKFIHNHQRGIPGLFFRYELEPIHLSLSATTMSFTKLLIRLTALIGGVWCCSGFAVRTLDKILPKRLKPHPNKHGDMHIPITSPNVNMPSPKLSPNLFGAASLLSTSPPPPYTVNNGMLSPGVANSNQGPFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ32</accession>
    <name>I4YJ32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955809.1">
        <property type="nucleotide sequence ID" value="XM_006955747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ32"/>
    <dbReference type="STRING" id="671144.I4YJ32"/>
    <dbReference type="GeneID" id="18474684"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61801"/>
    <dbReference type="HOGENOM" id="CLU_1476246_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ32"/>
    <dbReference type="OMA" id="SMERRIH"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="3">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="158" mass="18509" checksum="805526D7FCBC9563" modified="2012-09-05" version="1">MRYTPNKDLLPASTTIEQIQSNPDALRPSPFQFRQSKSTGKWHPPRYSRRQQADLVKEARIEGLLHLLPTSIKSSVDDINLNNSEKPFNWQEKAAFDVQAKSPRAVAEKKFRGSLWERNQPKRQAAIEENMESMQQKIEFWKLDKEQRKKKHTPPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ37</accession>
    <name>I4YJ37_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rad1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955814.1">
        <property type="nucleotide sequence ID" value="XM_006955752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ37"/>
    <dbReference type="FunCoup" id="I4YJ37">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ37"/>
    <dbReference type="GeneID" id="18473141"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59040"/>
    <dbReference type="eggNOG" id="KOG3194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035332_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJ37"/>
    <dbReference type="OMA" id="WSQAYKF"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33586" checksum="5445EDEBE96DAB5B" modified="2012-09-05" version="1">MTLLTAHASEIRSLHAVLKSIGFSKTAILHIREAGLQLSVEVGLEMVANAYIPSSYFDEYTYNSDEESISMEISISSLIETMNIYGTATFTSDLHSSEQGGLIGTTQLKLSYEGYGYPLVLDIITPPLDQQDGSIWAPMTTVELKTYDRDDRDILPFDHENLQMKVIMHSGWLLDALSALDPHVQVLTLTSPADASRNAAALRLSAISETASLEFDFPETEMAATREDGPIDSISRWIDGIVSEKYKASHLMHALKAIQASHKTSLRINDDGVLSLQAMVLDAHKKQAFVDFVCRPVEADEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ39</accession>
    <name>I4YJ39_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">WALSEDRAFT_30772</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955816.1">
        <property type="nucleotide sequence ID" value="XM_006955754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ39"/>
    <dbReference type="STRING" id="671144.I4YJ39"/>
    <dbReference type="GeneID" id="18471176"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30772"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009484_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJ39"/>
    <dbReference type="OMA" id="QPYRFST"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="31">
        <location>
            <begin position="557"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="32">
        <location>
            <begin position="734"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="EIM23981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="869" mass="94884" checksum="4D06247E3B50C791" modified="2012-09-05" version="1">MSSTKKYRFSTECVTIDNPNAGKDQYNSSSVPIYQSATFKGMNGEYDYSRSGNPTRTHLEHHLAKISSAKHAFAVSSGMAALDIIARILKPGDEVIAGDDLYGGTNRLLGYLKSNAGVIVHHIDTCTPSTVEQYLNKDTTRLVLLETPTNPLIKICDVKDVADRVKASCPDAIIVVDNTMMSPYLQRPLDFGADIVYDSATKYLSGHHDLMAGVVVCNRDDLAKHMGFTINSVGNGLSPFDSFLLLRGLKTLAIRMDRQQATARIVASFLNKLGFVVHYPGLSNHPGHDTHFKLARGAGAVLSFETKDIKTSERIVGSAKLWGISVSFGAVNSLISMPCLMSHASIPAHLRAERGLPEDLIRLCVGIEDYEDLIDDLENSLVQSGAIRTRFTPAEENWSSEIGSLERIGEERAMAWEKCSMFEEQPTVKAASTAETKKEGGNIVVSAPGKVILFGEHAVVYGVTAIASSLDLRCYGCLSPRSDNSLSISFPDLDTDVTLEIEALPWKAVKNAHDDILDIDHELVAALENHFPAEKFNSKARGAIISFFHHYMSICYNDRRAVSFSARSDIPIGAGLGSSAAYSTCVSTALLILAKKVAIEHTHNATHISHDGRRFINDDIAKYVNKWSFVSEKILHGTPSGIDNSVSVFGGAISYSRVRDQAMINLNGFKSMKLLLTNSNVDRDAKKLIAGVAKLKQEEPEVVKGVMDGIQGIVDEAVRCFNDKDLNRNVLLNGLSELVRTNHGHLDRLGVSHPTLEIIISKLQAYNLKTKLTGAGGGGCTVTLIPDDYDEKELGDALQKLQQAGFDTYLTTVGGSGLGYLIEEYNLEKNTQSTNEEESVGPFTSVFSKDFPTNELNSKLRESGHWVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ75</accession>
    <name>I4YJ75_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955850.1">
        <property type="nucleotide sequence ID" value="XM_006955788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ75"/>
    <dbReference type="STRING" id="671144.I4YJ75"/>
    <dbReference type="GeneID" id="18473148"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59055"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1103499_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ75"/>
    <dbReference type="OMA" id="MYRWIST"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="252" mass="28750" checksum="0480F22832CA3265" modified="2012-09-05" version="1">MSAKEVAMESEEEEEEVDELASEEPSELGSQDEEEVEEEDEDEEMEDDFDDDDEDSKKPAARRGRPPGSTNKRAKGKTGQKSRISGRTSTRTRQRSRSEEIDEISSGNEELADEDDSTSASTSKKDKEEQRLTARQRAALNDGSSETPELMSLDIGRQHKIILTEEEQALKRAELLRRRRHQSDQRLENEKTETINRLLTKTASKRRGRKEKEKEDDDDENASTQPLSEEKPEVLLAYRWVSNKSGTTFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ84</accession>
    <name>I4YJ84_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_26749</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955859.1">
        <property type="nucleotide sequence ID" value="XM_006955797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ84"/>
    <dbReference type="STRING" id="671144.I4YJ84"/>
    <dbReference type="GeneID" id="18470950"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26749"/>
    <dbReference type="HOGENOM" id="CLU_776601_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ84"/>
    <dbReference type="OMA" id="QFLAPNI"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM24026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="330" mass="36110" checksum="39630DE044527600" modified="2012-09-05" version="1">MSSQKSQMVSPDLIRAAQASEPIAIKDVDSHDLTCGRGASVQHQDHPVKIDAGSKLQIQWSDDWKHTVGPIMTYLAECRENNCEESDVTTLDWFKIDEKAADLEGDWWQSHLGDERVYIPIPSTLKDGKYIVRHEVIVIDQDPVLFFPACAALDIQNGGDEFPSSNYTVQIPGAYSATDKGLQTVEESFDPYNYVFPGPSVWKPTDVVESASFDGFYSAAEMDVHMTGDAYQVQFLAPNVTSSSTSSVDYVSSTATTLYPSQTMSMAASKSSTTSSSKPTSTANFYHAQLAPLPSDSTASPSSTPSPSISSTEWDDGSWNKQKYDDGKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB9</accession>
    <name>I4YJB9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_34611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955889.1">
        <property type="nucleotide sequence ID" value="XM_006955827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB9"/>
    <dbReference type="FunCoup" id="I4YJB9">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJB9"/>
    <dbReference type="GeneID" id="18471874"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34611"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_7_0_1"/>
    <dbReference type="InParanoid" id="I4YJB9"/>
    <dbReference type="OMA" id="IAMESEH"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="41290" checksum="E51A5BA9AC9D8BF1" modified="2012-09-05" version="1">MNYNEIKNQVKTKGLGTYLNSLFNDNNINIKDLVNTLDNNINLENKSNLQIKKLLKSRLFLIKRENVITSKDLNDAIKLIEKSSKIVVVSGAGISVNCGIPDFRSKGGLYDSINSLKLTEISDPQEIFSYYVFTNHPKLFYSIVKSILPSNFSPGRAHSFIKALQDNDKLLRNYTQNIDTLERKAGITNLLECHGSFAFLECLRCERIYNSDDFSEMITNGEIPVCTENCKREYKRRRRKRKSDQTSTDTTLDITDEAIINFFDTKNEVIPFLKPTITFFGEDVHPDYEQNVLEDSQIVDLVLVLGTSMAVAPISELLAHIPHKVPVIVINNTPIKAIEPDVFLQGDIDKIVNDISSNLNLNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJJ6</accession>
    <name>I4YJJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955963.1">
        <property type="nucleotide sequence ID" value="XM_006955901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJJ6"/>
    <dbReference type="FunCoup" id="I4YJJ6">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="GeneID" id="18471199"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30861"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJJ6"/>
    <dbReference type="OMA" id="WRKGGYQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34824" checksum="3AA12106DA1B3BFE" modified="2012-09-05" version="1">MVIACIYNILWTYSLSEITGNVSQVDRVWTVLPLLYTAIPTFDLAIKTYLQAPQSTSLVDVLKITVNQRALLLLALQFIWSSRLTFNTARRGLMAFASEDYRWPILKKKLNWWQFKLLNLFFIAIAQNILHLLTGLPAFVLTKTPQYDINRNDYFLFTLGVMNIFGEFIADNQQYAYQSWKHAESTIVAYNNGTLTKEEKKKYTDGFNTSGLFAVSRHPNFAFEQTNWWIWALLVVLGSKQPAEEILSTFISPISMSLLFECSTRFTESITSSKYPNYKNYKKKVAMFIPQFTLLKNICNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK8</accession>
    <name>I4YJK8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_14150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955662.1">
        <property type="nucleotide sequence ID" value="XM_006955600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK8"/>
    <dbReference type="FunCoup" id="I4YJK8">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJK8"/>
    <dbReference type="GeneID" id="18470626"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14150"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJK8"/>
    <dbReference type="OMA" id="GAVHLHQ"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="183"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="402"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="910" mass="103390" checksum="0B0DD63D5A43C6CB" modified="2012-09-05" version="1">MDVYGTQPTSSDDTESTKQVLILEFTDVRSIYSRNAIKQDVQLSRAPTLSRSDTLKLIERRNDRFKVAVNELLQATKETGDDPVQLVISAAHHHLPSKPLLNPSVKNSLAQQSLPTQRPSIEQVLEEFRYQDWYKDQSIFHKTIPARQALYSDWDLVIPEPIRRGLRSTLYVESLFAHQAQAIQSLNEGNNVIVSTSTASGKSLIYTLPFLMSFYQDRESTAFFIFPTKALAQDQNTKLKDLLRSIEGMENVIVDTFDGDTPTDRRDDLRDNASLLFTNFDTLHHTILPKEDKWRRYLANLRFVVVDELHYYSGVQGTHVAFVMRRLRRLCAALGNVNIKFISTSATIGNPVRHFQTLFGVEKVTLVDVDGAPSGQKEFLIWKPALIDELMPNGPRNNPMHEVSQLMRYLISRGVRTIAFCKHRKSCEMLMKHIRHELIAEGRMDLVSRIVSYRGGYNQDERRRIEKDLFSGYLLGAVATNALELGIDVGALDAVLCLGFPYSLSSLRQQMGRAGRARRDSLAILIAESLPLDNYYSNYPEEIFTRPPTDLQVDIDNDAIFEPHLQCASDELPVSLVGDRVYFGKDQLERVAARSLDRDDQGWYHCDPRLRPYPSRFIKLRGNEESIYKVYNVYKNSESLIEQVEESRAVFELYEGGIFFNAGLSYQIYEVSHDTKICRANQVNVNFNTKPRDYTDVDPIETCRMRAIKGSTMRAFYGRIKVSTYVFGYLKLRDFKVLDIVDLDTPPYVRLTNGFWLDVPANAMHIMNIKSINPAEAIQAAQHALMSLTPLYTMSAEGDIQTDEKKSVKEYQQKESKRKRPGRLILYDAVGKASGISQKAFERISELLYHTLDNILKCECSNGCLSCVQGEVKDGQASTSKLGAIVVLSSLIGKQLSMDDIPDQVCFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL1</accession>
    <name>I4YJL1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955977.1">
        <property type="nucleotide sequence ID" value="XM_006955915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL1"/>
    <dbReference type="STRING" id="671144.I4YJL1"/>
    <dbReference type="GeneID" id="18475197"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67005"/>
    <dbReference type="eggNOG" id="KOG3040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_4_0_1"/>
    <dbReference type="InParanoid" id="I4YJL1"/>
    <dbReference type="OMA" id="HKAKYIQ"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="255" mass="27917" checksum="CA3432B67B9A8862" modified="2012-09-05" version="1">MKGILIDISGTLVTSNGVARSTINAINKLKLKGIPFRICSNASKESHNKVISDLSTKLDGIDLNPNHVITAISSSKSYVTHSNLNPLLLLSNSAKDDFKDYSSDKTDYDSVLIGLSAESLNYPNLNNAFRILNQPGSQLIATHASKYFADKDNQLSLGPGGFVKALEYVTDKKAIICGKPSDEFFISCLKSLNLRESDWKDVAIIGDDALSDLGTSLPLRKVLVRTGKYRRGDEDKVKDLYGIYDTFADFVDSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL7</accession>
    <name>I4YJL7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_26860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955981.1">
        <property type="nucleotide sequence ID" value="XM_006955919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL7"/>
    <dbReference type="FunCoup" id="I4YJL7">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJL7"/>
    <dbReference type="GeneID" id="18470959"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26860"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJL7"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000141">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="336" mass="36285" checksum="062373A39426BC0E" modified="2012-09-05" version="1">MSQSPTPVKYGPDLSVKLICPECQIPNPNVVEEFSSGDLVCGDCGLVLGDKVVDTRSEWRTFANDEGDDPSRVGAANNPLLDGVDEFETMISSRDGNTGISRELQRATAKSSHGRSERGLLNAFRDISSMADQISLPRSIADIAKQLYKRVDEEKLLRGKSTDAIIAACIFIACRQAGVPRTFKEVWGLTRVPKKVIGQCFKVLERAFGSNSPSMTPGVDTPTLNNIQSGPEDLMARYCNHLNLPVWLQSGAVDVAIAAREHGVLAGRSPITVAATCIYFASALFGHPKSASEIGNIAGVGDSTIRSAYKILFNEKQPVLASIHDKRANVMNLPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW3</accession>
    <name>I4YJW3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_30951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956071.1">
        <property type="nucleotide sequence ID" value="XM_006956009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW3"/>
    <dbReference type="FunCoup" id="I4YJW3">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJW3"/>
    <dbReference type="GeneID" id="18471217"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30951"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJW3"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="21098" checksum="EC582E7000A0F72D" modified="2012-09-05" version="1">MNANKLKQYGEDQWRAKPDKLNAELFVMTYGALVMQLVQDYEDYSAVNKELDKMGYNIGTRLIEEFLSKNPEVKCKNFNDTGEAIAKVGFKTFLNITPEVVHNGSNEFTLVIEDNPLNQFVVLPDTAIREGLLYSNVLAGCIRGCLEMINISTTVDFLSDELLGQESTAIKVKLIKYLEEQVPSDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y504</accession>
    <name>I4Y504_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668276">
        <property type="protein sequence ID" value="EIM19046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960909.1">
        <property type="nucleotide sequence ID" value="XM_006960847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y504"/>
    <dbReference type="GeneID" id="18475138"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66729"/>
    <dbReference type="HOGENOM" id="CLU_2980855_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y504"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="58" mass="6875" checksum="5C834DEFCFA47BF6" modified="2012-09-05" version="1">MDKQSKTNDQQAPRPGTDGRTSYKLIRFTYEREKWNKKPSILETDRRGSTSVFPWNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y596</accession>
    <name>I4Y596_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_34245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960800.1">
        <property type="nucleotide sequence ID" value="XM_006960738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y596"/>
    <dbReference type="STRING" id="671144.I4Y596"/>
    <dbReference type="GeneID" id="18471841"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34245"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_5_2_1"/>
    <dbReference type="InParanoid" id="I4Y596"/>
    <dbReference type="OMA" id="ETEWSYS"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40976" checksum="17803AF5D76D61A4" modified="2012-09-05" version="1">MQQSPSLYYYNQYKAATEPTSTAAQQSFPYNPEYQLRPIDTGYRQTTLNNDNEIEKLNGRHPIDLAQVAYDDKVYVIPQGESENLRLNREHELFKFIIGGLWWGPLSEVVSRTTRAGKKGVIGDWGAGTGIWAMELAQQFPGADTHGNDIQCITPIRGRQVPRNCFYRCVDITKDLTLAYQPESFDAIQIRCLYAAIQDYPALLRDSLPLLRPGGLLLLMEPKWTTVSRSKTAGPCCRTLATWIEQLFVEKGLDPGLDGNKLESYVRASGEFDEVKSKVFHARIGAWPAYSGVDLPNRHVAHLFADDLLNLFRSFIPIFLKRGYYEPDINNIIARAAKETTLTKYRIVEELHYTYAIKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G2</accession>
    <name>I4Y5G2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960776.1">
        <property type="nucleotide sequence ID" value="XM_006960714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G2"/>
    <dbReference type="GeneID" id="18474631"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61599"/>
    <dbReference type="HOGENOM" id="CLU_1220507_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5G2"/>
    <dbReference type="OMA" id="PDISHKR"/>
    <dbReference type="OrthoDB" id="10509519at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="23270" checksum="B61EDF78522D7CA8" modified="2012-09-05" version="1">MTMFKLPEWSSRRSDAVVALSTQSTNNFDNINKHTEERRMSAAESLLMLSPNVRPTTSSSKSMSQSIPQANTMHKARSNSIIGSLPPSPPWSPAPATPIAFPSPRVIPLRKSSRDNSSPGSSLNDDPLDLDADAPFELDQVDEEDVDEEKEQAESPVVFNMDSFKVPGHAQPMTKTSSKTSSRSSSRGRRSSKAPDDERGRSRHKNSSKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G8</accession>
    <name>I4Y5G8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960707.1">
        <property type="nucleotide sequence ID" value="XM_006960645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G8"/>
    <dbReference type="FunCoup" id="I4Y5G8">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5G8"/>
    <dbReference type="GeneID" id="18473074"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58838"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5G8"/>
    <dbReference type="OMA" id="IDLYQPC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="36941" checksum="65BDEB1C8D58578E" modified="2012-09-05" version="1">MPNILDKDVRGIGHGLMGMTWTDTPTPIDTALEVMKKSIEVAKGHPVTWNGGEFYGPPEHNSLHLLKAYFTRYPEDVDKVILCIKGGMNLQTFKPDGSYEGLSASVDKCNAILDGVKKIDQFEQARRDPNVSPTEIIENLARLEEEGKIGALSLSEVGEKTIREAAEAAKELGTKISSVEVEFSMASTDILHNGVARACADYNIPIYAYSPIGRGLLSGKIRSKEDARGIAKVSPRLQDENIAENLKLVAEVEKLATKKDCTPAQIAIGWVKHHSNWNGLPAIIPIPGASSVKRVEENLNDSITLSDEDMNHLQDVINKIEIQGGRYPESHSAYNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H9</accession>
    <name>I4Y5H9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960718.1">
        <property type="nucleotide sequence ID" value="XM_006960656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H9"/>
    <dbReference type="STRING" id="671144.I4Y5H9"/>
    <dbReference type="GeneID" id="18473075"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58848"/>
    <dbReference type="HOGENOM" id="CLU_795010_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5H9"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="349" mass="39111" checksum="7BD61005FAFEA2F2" modified="2012-09-05" version="1">MFTLPPRYDDLEAQKSRSIIMNKNASQISTNSGLAREEETKRCWFYLDPRGIEHGPWSSKTMQNWYTSKRFLSNLPIRHQKMRYHKTLTELISQFGAEKPFIIALGSIIQQSPANSLKSLDPPTPLLPPISLISDPSLPQKGPQNVYLVARRNLPTMLVDQVGRSIVRGSGIHWDYNNVDTHGDIKQFEMISTSDDGSKAAIVAIRDSSFEVLDIADALLSTPSEREKALPGWEANMSREGRRLPYVHRLRSTSLPPKSAHKRAFSSTTHLSERHNGNKKVDLRGGLQDNSTVSVPDLAKINSDDNNNDTTTSQIIYVGKEKDNETVYFLESYNDGSTGISVVSVHYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J6</accession>
    <name>I4Y5J6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_49331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960735.1">
        <property type="nucleotide sequence ID" value="XM_006960673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J6"/>
    <dbReference type="FunCoup" id="I4Y5J6">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5J6"/>
    <dbReference type="GeneID" id="18472495"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49331"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003364_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y5J6"/>
    <dbReference type="OMA" id="WMWEWHT"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="144"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127149" checksum="465C261ABD243F31" modified="2012-09-05" version="1">MVKGMAKHGDSSYSCKPLLDAVNDLPGKPSLRDVIIKYSHFTSLSESFAAVSVLTRAAASAGNVPLIEELASIHAELEKSMNGVEEENASLPDEAASEAVQGEEDIMGVLSPSTSETPYNLYSLRQSLKPLGHTSKTLAGDPAARQRLLEESAYETAKARFEHEMNELEKAGVSTALSGHPLQKLMWDWWKKVSVDIQAKLQKSMETTNPKTKEEKFMNEITPFLSLLSSEKMSLITVLEILRLSGTGGIAEGMKTTRALLSVGKAVENEHHAEILKQKHGISLKGVEADAKQVKRKLRYFDHRKAEKELDLKSPEFTGLIDDAMGTSEQSPEAHSHDIASERAKARVVEERMNKAWTPNWSQIIRIKVGSFLVDSLMECATITRTAKHPESGEEMTEAQPAFSQSYQYVRGKKLGVIKVNTAVADRLDKDPLGSTIHPRHLPMLVKPKPWLRYDSGGYLFHKNSAMRFKDSNEQQSYILKASSEGTMEPVLAGLDVLGATPWNINRKVFNVVKEAWNTGEGLAKIPPATTKTPDPVKPANYAIDPKERSNYLQSMKAVVNERRNNHSIRCDTNYKLEIARAFLNETFYFPHTLDFRGRAYPIPPHLNHIGDDLSRGLLIFAEKRPLGEKGMRWLKIHLANVYGYDKASFNEREQFADEHMEEIYDSADNPLNGRKWWLKADDPWQCLAACYEIQAAMLSPNPLAYESALPVHQDGTCNGLQHYAALGGDPMGAKQVNLEQGDRPSDVYTAVADLVIEDIKKDALESDNEFAKILEGKITRKVVKQTVMTTVYGVTFIGARDQIDKQLQDRGDIPQDKVYTTASYLAKKVLRSIGDLFAGANAIQKWLSMSARYIAKSIPPERLIRALEPLEAKRKNSPANKGNVSTRTAKEQMTSVIWTTPLGLPIVQPYRKAKKKQVATLLQSVYLADPNIPTEVNPIKQASAFPPNFIHSLDATHMVLTALQCSQIGITYASVHDSYWTHASTVDHMSEIIRDTFVKLHCEEILKRLRDEVIERYKGYRIPISSLGAKIDKENPKIAPLLPKRSKKVAKKEAEREEEEEEESEDLMNITSEDLEAIETIKAKTNDDLNLITKDDEISDFIKSKYIKLEDVLPDLPKKGPFDVRGVVNSPYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5T4</accession>
    <name>I4Y5T4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CRCB-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_70669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960602.1">
        <property type="nucleotide sequence ID" value="XM_006960540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5T4"/>
    <dbReference type="FunCoup" id="I4Y5T4">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5T4"/>
    <dbReference type="GeneID" id="18475772"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70669"/>
    <dbReference type="eggNOG" id="ENOG502QT5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030507_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5T4"/>
    <dbReference type="OMA" id="ADGYCGC"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="34655" checksum="0B43415EB047EA5E" modified="2012-09-05" version="1">MPRPSTSLIANELRGLGLIIPASMLGVLTRLALSSLTNYPSPLLPPVIYSQAIGSLVIGLANGLKPSLEFILTDLTLAIATGYCGSLTTFSTFMLDLWKSYTYVNTPNYASRNAKGAAFDFLSYILSTSCISIASAQFGLALGKRIQERINLSKESYQHKSKISLGAAIALGVVSYVITLALALTESTHRLRTWTYALLFAPAGAYMRHKLAGYFNKPGVYIPYGTLMSNVLGTVFTCLGFGLFHLSGASQSSQVRCNVLQALQDGLGGSLSTVSSMAMELNAMGVSRRCFLYSATSILLGQAICIIITGGMKWSSQGFGDSCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y604</accession>
    <name>I4Y604_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960546.1">
        <property type="nucleotide sequence ID" value="XM_006960484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y604"/>
    <dbReference type="FunCoup" id="I4Y604">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y604"/>
    <dbReference type="GeneID" id="18474556"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61480"/>
    <dbReference type="eggNOG" id="KOG4592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012622_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y604"/>
    <dbReference type="OMA" id="CRHVIYP"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="619" mass="69286" checksum="4EF304B6E076A0D3" modified="2012-09-05" version="1">MKDDALPTVSFTDTLKMHTPDILDSPQIDFSSALEPSLEQSLDRTHISQPAVVPPPMPVQQMQQVQQMQQLHHMQHIQQLQQQQMQQPDVVFPALPTQMESIPTNHSETMEKIIRDQELQDLKRRRKAIKISAMSNFNHLMTPSDKSYILRMQLSSLATADPYTDDFYAQIYSILMRKNQGVLNVGGMALSVAAGSNQSGMGAGAAKKLRDQIDKIVRSKREKQEDNTNKQSQEDYLVGALGKTSSKTNSRAPRQVLQVPSNESTKASAKDVLSSLEKGGFASSLLNGPQPALTRRQSLIASEKLYDYVLNLENLRRNQPQPIQPTEENPNPEQPYEEMSRWEQEYNFNVDELWKGLRVMEPLELSNPHPFISLIAITKTSKLLPRAIRHLDQQQVLTINTLIIACFSQYLRFNQDSNLVEAFLSGIVPQFMSMITGVSLRLVAGMLALFVERNDVVQVAQSKPGLAFLTILLSRAEILKQIPMGIENAPNPEEISQWDQIFSLFFSKLLPCLPSLFPSQRHKTARAFGMGAAMPSGSLEESILLDSEDESVWRFLAAIALNSDNIQQSTLVQEVRDVVQENVIAAQQAWVPPQSATKKIGNVNVFLHALGLDVSQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y683</accession>
    <name>I4Y683_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960507.1">
        <property type="nucleotide sequence ID" value="XM_006960445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y683"/>
    <dbReference type="STRING" id="671144.I4Y683"/>
    <dbReference type="GeneID" id="18474546"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61464"/>
    <dbReference type="eggNOG" id="KOG4719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264287_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y683"/>
    <dbReference type="OMA" id="KEPAHNT"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1202" mass="125840" checksum="36B5558C4BEDB5AB" modified="2012-09-05" version="1">MSGRDEGLSTSLGPQRRASRNTPSKPYERPAVQATPTRQPSTAGLMNSVRSLVAKPFSWLTGSKNTPQDEENAQPIDSPWNKSTTQARTLQPPPRAQQRPHTFYNDLPSSFVKSNHLTIPGSNNRESQTLSASYTPRLASSYNGRSRSPFTPVRHLMPGSPTASPRRSLLGSGRNASPLVPRTRYRAPTIGKRSPAPDSSVRSILSAAEDDDGDFNPYAHSRTGDKRSSFIEATPDRPSKRRATDAKKMVYNREADEFMSLEEAQARKHVPPAPKNEAERILLALEKMRTPLTDARKSNPLSARAPLPASQQSHSPLPAVSVPVPNLTNSKAKNNKLAPVNKKTEAMISPYARSKSRREEERRQRERDMKTSKLQEKLPKVQRPKNKIAVPSDDEDEETSGESKKSASVDVSKTSSQASSSTPPVATTSAAKLFAPISKDEFKPGERGQSATERARSSLRARTMTSSRQHSSAARKPGRAEESGEVDEEEEERKRQEEREALKSVPVVNFNFGNQATQTEAPKLNFKLPDEKKDEEQKPSTPKPAAFSFGESTTPKVPPPSSNLFAGLNKDNEKKLEESKPAAPATLSFSFGAPKAEKSEKEKDEEEKSKKAAAEKPNPFALFEANKKTPSEKDSSDSDKAAPSFSFNKPAETPKPAFSFGGAPEKKEEEPKKEDKPAAATTPSFGGFSFSKPAEEEPKKAPTFGFGGVSKPVEEKKDVPPQPSLFDRLGGKPEEPKTQPSLFGKPAETPKKDTEAPKPAFGGFGGAFGSKPDEDKSKATSPFSFGGTPFGASKPEDKPAEGEKKEDEKAPTAGGFSFGKPDEQKSTIGSSGSGFTFGAPKPVENGTSPFAFGQAKPVEEKKETPAFGQPAKAADEKPAFSFGAAPAGDANAEKPKVSSPFTFGTPTAPSGAAEAPKPAFGQPPSEPTKPSFGFGTPAATSTGETSKPPFAFGGSQSTLFGGASAAASPSTDNKPGFSFGAPSAGASADKTPFAFGAGSGSTSAPAAESKPSTFAFGSANAGTNSPSTFQFGSGAGATGTAFGGPKPDQGAGGDSMEESPTRPAEPAPLFGAPAAAPSPSPFGAAPASSGFTFGASQPAAPAAPAAPSPAFGFGGGNTGASNGAPSFGGFGAAPTAPSSANTTAPTSPFAFGAPNPSAAAPNPSTPQQQPGSPNLFNMGSGSPAPGTPNSSRPVKPLRRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6C6</accession>
    <name>I4Y6C6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960443.1">
        <property type="nucleotide sequence ID" value="XM_006960381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6C6"/>
    <dbReference type="FunCoup" id="I4Y6C6">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6C6"/>
    <dbReference type="GeneID" id="18474528"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61425"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6C6"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="498" mass="55838" checksum="3969BA071442340F" modified="2012-09-05" version="1">MFKQTLKKSIQNSSTRLSKPANYGQPIAHTHPYLMKDSDLTPGISVREYEQRRKKLIGHLNPGDTVVCVSGKVKMMSQGIFYSFRQATDFNYLTGFQEPDSAVILERDDTLARGYKMILFVRPKDPHIELWDGARTGLDAAVNIFKADESKPMSTLASYLKSTLRAHKTVYASHPDLPDKLKRRVSFNSSTSHAKALVDYLSTALRGQGNTESDSVLSTLGLPNVKPLAPIVQGLRSVKSLAERNLMRQSGRIAGNAFRDVMAFAKPGMNEHQIAARFEYKCALSGAERPAYVPVVASGANGLAVHYTANTMQVEPNEMILMDAGCEYHGYNSDITRTWPVNGRFTQPQRDLYQAVLNVEKACIKLCTEQKRVSLNYIHRESVRLLGQELKQIGFDSLRYGDLERILYPHYISHPLGMDLHDTPSFDRSQTLVEGNVVTIEPGCYVFPHDRFPKWFHNIGIRVEDDVLIGKDEPTILTQEAPKDIEDIESACNVVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6G2</accession>
    <name>I4Y6G2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nas2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960352.1">
        <property type="nucleotide sequence ID" value="XM_006960290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6G2"/>
    <dbReference type="FunCoup" id="I4Y6G2">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6G2"/>
    <dbReference type="GeneID" id="18475092"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66190"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073146_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y6G2"/>
    <dbReference type="OMA" id="ARHTIIC"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="20265" checksum="A4D601D634699DFE" modified="2012-09-05" version="1">MSDLINKREDINNELNIIFSYFKDNNIKKSTPLLDKEGFPRNDLDIVTITQYRQRLTVLQNDLERINQDIYKFLEQQPKTAASSDRKPIKHSTPWSIVKSIKPSSIADNAGLLKDDLIIQFGPFSHLTLDNFEKLPGFIQENRGNDVRVIILRDNQEITYTFNLNGSPLGLHIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6L5</accession>
    <name>I4Y6L5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein rhoA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960405.1">
        <property type="nucleotide sequence ID" value="XM_006960343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6L5"/>
    <dbReference type="FunCoup" id="I4Y6L5">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6L5"/>
    <dbReference type="GeneID" id="18471784"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33965"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="I4Y6L5"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21802" checksum="B47144638BF59286" modified="2012-09-05" version="1">MSSEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVMHFCQGLPTILVGCKKDLRNDPKTLEELRKTQQRPVQESDGRGVAQKIGAKHYLECSARSGEGVKEVFQTATRAALLTKSGNRSKKSKCVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6P2</accession>
    <name>I4Y6P2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960297.1">
        <property type="nucleotide sequence ID" value="XM_006960235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6P2"/>
    <dbReference type="FunCoup" id="I4Y6P2">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6P2"/>
    <dbReference type="GeneID" id="18474486"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61367"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y6P2"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="654" mass="70652" checksum="C223E5BCCD38551B" modified="2012-09-05" version="1">MLPRTLRSTAFNRIPRAVPKLATRFQSNGRATGPVCGIDLGTTNSCVSIMEGQTPRVLENAEGGRTTPSVVAFSKDGERLVGVPAKRQAVVNPENTLFATKRLIGRKFTDKEVQKDLNQVPFKIVPHSNGDAWVEARGQKFSPSQIGAFVVEKMKETASNYLGKSVKHAVITVPAYFNDSQRQATKDAGTIAGLEVMRVINEPTAAALAYGLEKEDSGVIAVYDLGGGTFDISILEMQKGVFEVKSTNGDTHLGGEDFDIALVNHIIGEFKNSDGVDLTKDRLAVQRVREAAEKAKIELSSASQTEVSLPYITADASGPKHLNLKLNRSQFEKIVGDLIERTISPCKKALGDAGVKSSEINDVILVGGMTRMPKVTETVKGTFGRDPSKGVNPDEAVAIGASIQGGVLAGNVTDILLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADGQSAIEVKIYQGERELVRDNKMLGNFQLVGIPPAPKGVPQIEITFDIDADGIVHVTAKDRATNKDQSMTISSSSGLSEKEISSMVEESEKYAEADKERKNVIEMANKAESIATDTDKALGEFASQINEEEANKVKESVAKLRELGAKGQSGEEITSEEIKTQIDETQQASLKLFEQVYKNRQSNEGEQKPEGEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Q7</accession>
    <name>I4Y6Q7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960312.1">
        <property type="nucleotide sequence ID" value="XM_006960250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Q7"/>
    <dbReference type="GeneID" id="18474491"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61374"/>
    <dbReference type="HOGENOM" id="CLU_1807712_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Q7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="15719" checksum="E3E420EBD9FB5C97" modified="2012-09-05" version="1">MTIAISSVLAFDIHGTPEVCCDTKYYTLASEAKQLVKDLKAGKVDGEHHWFENGDTIWESSGATFSGKERADRLQKIIDKCTTDDGISVAGHDCLYDSNASTNSMCLYKGPQAGCDFGNNCLDLHWNKSKCHFPISQGFIMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R9</accession>
    <name>I4Y6R9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960323.1">
        <property type="nucleotide sequence ID" value="XM_006960261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R9"/>
    <dbReference type="STRING" id="671144.I4Y6R9"/>
    <dbReference type="GeneID" id="18474494"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61377"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378207_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6R9"/>
    <dbReference type="OMA" id="MYLESEP"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="166"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="731" mass="82020" checksum="C62CF0860A41D229" modified="2012-09-05" version="1">MFALEVAHSTSKCEMEFDFQSAFHPATPPYTDSSGAEFDEAISSLLEQSPQEQHVDISDTNELQNWLQSQPIFNAYEDPFQSLQAGLLNTDSVGVDPRGGLMLPDLQAMENVQPQEASKPVNQPKATKRKAGDSSNITKKQKSEAQKQRFPKPPQPVPPAPSHGGPKNPSHNAVERRYRNNINTRMLSLRCTVPALVAQPPPQTSSRRKPPPLYVEGVAVPNKINKQTVLIGATDYIRRLRGREQRLMREVELLRATLPPAEKISWEKEWGAVDDRDLYDTIEDFVPPDNTFVDLVDEPISSTSDEQQSQQSPSSDGSSAPRYLLGMFLSFGLLQKPYQKQQHLFRRRFEEGTILSSSLPSNATDEQFQWRQHIIPDLYHPHVHDIIQTILICLTLAVLLYPLLPSVKSNPLVKGVEIGWMSLQRLFSFKRGETTDVTIKHAQRQIYSSKDYSKIDKLHTYMTLASSRQIKESPLALATAALHSSSNKHWKAAQAMKTLENEPRYVQLALERDLNDALQLCKMGDNTSELNVLQKISTNVSILALEELWSLIFTQIVEEKASASDVQLINKAITQLMISSKDLPFVSTMSTLSAAMWALFQGKTSIAFHLASNVSREASSLKCLRVFSMLTNTSINLEDDDEDVTDKQFARCDDLATVTMLYFSLKISLQGVKEGDENKEQARSLYGLTLRLRSLLGSLDKEDSKLLDNDTFDAAVDCLQVTGYKLMGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6S5</accession>
    <name>I4Y6S5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_13355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960275.1">
        <property type="nucleotide sequence ID" value="XM_006960213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6S5"/>
    <dbReference type="STRING" id="671144.I4Y6S5"/>
    <dbReference type="GeneID" id="18470613"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13355"/>
    <dbReference type="eggNOG" id="ENOG502SYK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204930_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6S5"/>
    <dbReference type="OMA" id="GKGMERM"/>
    <dbReference type="OrthoDB" id="412006at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8618" checksum="60646B26D4FA20FE" modified="2012-09-05" version="1" fragment="single">LINVANSSLHLGHYPKCFKEATCIVIPKPNKKSYREASSYRPISLLNHLSKLIETVITKRLQYELDTRKLIPSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T1</accession>
    <name>I4Y6T1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960334.1">
        <property type="nucleotide sequence ID" value="XM_006960272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T1"/>
    <dbReference type="FunCoup" id="I4Y6T1">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6T1"/>
    <dbReference type="GeneID" id="18474495"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61379"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009539_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T1"/>
    <dbReference type="OMA" id="RANHEES"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="585" mass="67398" checksum="BE1366DAF5FA4D88" modified="2012-09-05" version="1">MGNRQSTSTLSSDDDDSKDFYQLLCISEDASQDDIKKSFRKLALIHHPDKNPGNVEAANQKFSKLQEAYETLSDEQERAWYDQNKNAAEEAGEEDDAAAFEEMLNGQGARKTRLTKDPGITTRQLIRFFNPKLWNGYDSSSKGFYTIMGALYARLAEEEATAAPYDFEEDNGPCPAYPGFGDENTPFESTPRDFYALFGGFSSRKCFAWRDLWDLRDAQDRRVRRIMEKENKAARDEARKEYNETIRQLTFFIRKRDPRYRNYAKKQAQYASPEAAQQRRSEANEVRKKERNAAAATFVEQSWQQVSSYDMAVEEAEELEEMDKLHCFACDKNFNSEKAFENHEKSKKHNQMVKILRKHLEKEERELIKNGGGQRLNESSLQEHDYVQDAASSMCETPGESTPTLSTTVEAKVDNLIHETEIEHDIERQLDLNQVANNESESHTETETTHTSDLGSVDYEEKKINEEIDEQIVSQLDNLKVDGVEVENNRDPSPVPVKKPLYIPDEKPQRTKKEKRRAREAAKRALENAVPITLYCNVCHEPFSSRTKLFNHIRDTGHALAGPDDHKYKRNKKKGKRNTKNTKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X9</accession>
    <name>I4Y6X9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960229.1">
        <property type="nucleotide sequence ID" value="XM_006960167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X9"/>
    <dbReference type="GeneID" id="18474468"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61333"/>
    <dbReference type="HOGENOM" id="CLU_2943620_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6X9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="60" mass="7128" checksum="4DD33AB125ED6B2A" modified="2012-09-05" version="1">MELVVKKLFLSRLCLLINTKYVAHRQKIFILRSLHLCKADKRAGSFARLLKVTRVYMVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y722</accession>
    <name>I4Y722_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960272.1">
        <property type="nucleotide sequence ID" value="XM_006960210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y722"/>
    <dbReference type="STRING" id="671144.I4Y722"/>
    <dbReference type="GeneID" id="18474481"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61357"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="InParanoid" id="I4Y722"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="308"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="603" mass="66258" checksum="CE7EC289B123E82B" modified="2012-09-05" version="1">MTAEYFIGIDVGTGSARSALVNITGDILAESTYNTKTWRDANDANIFEQSSANIWQCISQSVKDVVRQAQIPKEAVKGIAFDATCSLAVTDYEGNPIAVTKGDSLGKEGERNIILWADHRAEKEATFINSTGAMPLQFVGGTVSLEMEIPKTLWLKNNMKPEDFKKCMFFDLPDWLSYRATRSTARSNNSLGSKFTYVTPSIKGAYPSGWDPKFLEQVGLGDLVQQDFVPLGGSPDKNGLVLTGGLPIGNGLTKEAAEELGLAEGTAVGSSVIDAYAGWIGTVAARSAKKGEELPKEAVAFEECATRLAACAGTSTCHIVQSPEGVFVKGVWGPYKNAVFPGWWMNEGGQSSTGQLIDFVLKTHIAYPELERVANERQTNIFEILEELLQKAKEEEGVDSINQINKHMHFYPDLHGNRSPLADSRMRGMITGLGLDGTLGDLARKFQLTLEAIALQTRHIIEEMNEAGHKVNSIYMSGGQVKNRALMQLMADVCQMPLILPASASGPVVAGCAMLGRYAYELSQKKDYTEIVKQQQAEQVGECNKRRLWQLMTEMTKPGERIEPNCSKKDSTLLNAKYKIFRESIDIQRKWRKEVEDALEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y769</accession>
    <name>I4Y769_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_61292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960145.1">
        <property type="nucleotide sequence ID" value="XM_006960083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y769"/>
    <dbReference type="STRING" id="671144.I4Y769"/>
    <dbReference type="GeneID" id="18474444"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61292"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066250_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y769"/>
    <dbReference type="OMA" id="AHGYGNS"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="228" mass="25433" checksum="CBF1C9FEA360E6F1" modified="2012-09-05" version="1" fragment="single">MKSSRSSNQTPLRRVSSGALTQSHNSSVNQKNIVQHPLEFLTPALSDLSDELDGILSSTHQMVELDKALADFNHGFGSLLWALKLNAYCVNWPEAPTDESFNRVEELNARLQQSLAPPREPTPPPAEPEHNPADETYRTQQEEEVVPQPPPKIQPKTKPKVVSVQLRKKREAFVDSVIESLPLEYRGSQPALRSAMSSVLHALMRHQCTTPEDNGIRVPDVVKQPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y782</accession>
    <name>I4Y782_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960158.1">
        <property type="nucleotide sequence ID" value="XM_006960096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y782"/>
    <dbReference type="GeneID" id="18475077"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66012"/>
    <dbReference type="HOGENOM" id="CLU_1696873_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y782"/>
    <dbReference type="OMA" id="RIRNCIT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="155" mass="17641" checksum="C240C83FD1A416E8" modified="2012-09-05" version="1">MRNALKLLEQFKPKVKILSFGYAVNLGSLGDRGMYTFQHSYFTLKILPPSKTESLVRTKLDSLPFPHNDFGLRYWLYLDAIGRQDGYGFKRVNVAELPLVVITPIAYTSKKAVIRNRLRKRIRKCVTSVIEQSMVTTRGGADDLILRGMSKFPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y783</accession>
    <name>I4Y783_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_66014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960159.1">
        <property type="nucleotide sequence ID" value="XM_006960097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y783"/>
    <dbReference type="FunCoup" id="I4Y783">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y783"/>
    <dbReference type="GeneID" id="18475078"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66014"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y783"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="707" mass="80003" checksum="5235C08962026A4F" modified="2012-09-05" version="1">MHLITLATSLNQWALDFQGNYERILESIKIAKSRGASLRVGPELEITGYGCLDHHLEGDTILHSWEILAKLLKDKETHGIISDIGMPVRHKNVNYNCRVIVNDGKIVLIRPKMWMANDGNYREMRHFTPWLKHRQTEDFFLPRIIQSTTGQTTVPIGDVVMSTLDTCVGVELCEELFTPGAPHVNMGLDGVEIFTNSSGSHHELRKLNRRFEPIKEATLKLGGIYLYANQRGCDGDRLYYDGCAMILMNGEVIAQGPQFALTDVDVVTATVDIEDVRSSRTSISRNLQAAQSQPMPRVHVPKALSYGIGENFLAADPSRPTELRIHQPEEEIALGPACWLWDYLRRSRTQGYFLALSGGIDSCATATIVSSMCRLVVKACQNKEQQVLDDVRRITGEPEGSTYVPDDHRELCNRIFYTSYMGTENSSAETRQRAKDLAEDIGSYHVDINIDTIIAAITDLFGVATGLKPKFKVHGGSYAENIALQNIQARLRMLLSYLFAQLLPWVRGRVGGLLVLASSNVDECLRGYLTKYDCSSADLNPIGSISKTDLKRFIGWAQTEFDLPILEHFLNATPTAELEPITQNYVQSDEADMGMTYDQLSVFGRLRKVDKCGPYSMFTKLLAEWKDTMSPTEIAEKVKKFWFEYSRNRHKMTTMTPSYHAESYSPDDNRFDLRPFLYNARFPYQFDKIDATVKRVEEINEQQPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y795</accession>
    <name>I4Y795_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_40862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960171.1">
        <property type="nucleotide sequence ID" value="XM_006960109.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y795">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y795"/>
    <dbReference type="GeneID" id="18472194"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40862"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000459_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y795"/>
    <dbReference type="OMA" id="TYRFFNV"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1578"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="969"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1445"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1819"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1909"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1445"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1925"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1948"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1967"/>
            <end position="1976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1987" mass="225826" checksum="54DC99C5FA51F7BE" modified="2012-09-05" version="1">MATPVEQILRNARAKPLTNEEVNNVIVPVSQYLFENGRENDQNQPNWFSDKYDGDGTLTEATAFLIRLFAYSPPKEELLIYKKHLTFQLFSNPKTVYDWQLCKLQARHVYLRNFKADKLNKFFALVHQWEVEAYSEHLKAAMSPLITLDNLDQSLYHISMLNPDIFFRKEVMSVVIQKLEGSSGFVEYLPPPPTILALTASVDDTVNKWANRMIDDYEWRPVTKENAKMYLILIENILQRIVDRENGNLESDDEWPFKEDTTALWTTLGKTLSVMEPSAIEVISRSSPNLLRDVQRHLCDAKTKNYIPLLRCFVALISVRQGYWSEDSHKASQMNKSDEHSVLLLRLMNSILDNPFYKPLMKVPIKFHKNDDEEWPLNWWSNLIKNVENVHELHDSALKSLSRRGFESTKDGDVNIKYKYYNNIISIFEKCFVDYENNERKLQLLFDVLRIYNTNLLETALTAQMGDPTKDQSIYAARRLLQLCMKKDCIRIIRGLNDFMSKFASWKDYERQVKRKKSAKEPDVTLDTKKIIIASDIWESIYKVIGVTNNIDDIFAWSLLLSNISLISHLRPLDEKTYDESAVPTHMKSTMATFKTSFNNAINTIQSPFQRTVDDYLHESASSNRLQALSNLVESTGVPSALIQLFLSPNDEINVSIINLLKTVSDEDSRNDAIQWLLDKYPQQFLEGITAQCKNFKYVADRHLEATTLAHRISSQNEEFLPMITSPSNHFLVTYARNPGIKQALLVYWVELCQFISTILTSATKWHKYFDNSFMVKWMRDSISLAGVLLDSEKDLERHITSTPSKMLDPLNKILIQSVGWLKATDMTVLEFTFRFIDSTLTAFKQSGCLPAPQALDKLSDYSRQASQGSVKKLSHLSLSKLKQHLATFNDESDDDDVQIIEKKPGLAKLNRVLTSEKKPSPAQFLEAKKKDDEAKEKLKQMALNKHSLVKKTTGKPLLTGLTAKKDQARKPYVAPQKLTYGGNKKEESESSEEEVDRGGLKDMDLDPEQAKLKMQAVKDKRSGVRALDPLVGSSTKSVVSKADKQRDESFLRRQRLDPDIGDLQKYLLNVDYNDPKMRIGSEAPIERIPSDFKDYKHYYDIMRPLLFDETSEQLKQARAAAQEEENVTVVVAGKTFVNDYAEIVLNVKCEAPYQFSLSDSELITLTKIDSITPGGQRIGSLTQDHPSKDLIAKVQNFRRRGQDIIVTVWLPTLRSSVFQDKQHWKLSKFYSLNTLYREFGALKGLQHYGSILSKILKPEVKPKQNLDSILVKNTMRTLELNESQALAVLSSLIGPADGAFSLIQGPPGTGKSKTILALVAKFLSMRAKPLVGRTNPNAAENYVPPKILICAPSNAAIDEVVNRLKVPIRGTDGQIMEVNVIRIGADSSMSISAKERSLEELVDQRVNQDQSDQGSGTESSMQVNEFRDQLTACRNKINEIRNEINRKQQKKETVTPAETEELRKLSDKRNEISTKLDKARDNQKSTAKARDASRRTHRRAVMMEADVVCSTLSGAGKGDLAELPVEFETVIIDEAAQAVEVSALIPFKYGCKRPILIGDQHQLPPTVMSTEASKKGYSRSLFVRLMESNQGRVHLLNEQYRMHPDISKLPSAVFYNGHLKDGPMMAEKTKAPWHSNDLFGTYKFFDFAGGERRVDHSYQNPDEASVVISLYERLRKQYGGEFSLDYRVAIIATYKQQVRYIRNELKKRFWNVDKDILSKVDVNTVDGFQGQEKTIIILSTVRSTKFEDDGIYKERGGGPIGFLKDIRRMNVALTRAQSSLFIVGHADKLKYDQTWQHIVDDAEQRDLLQKINRNHFSQPSNFVATKLKHPTSQEKDAQNKKKNKTKEREQPPIPDNLVPTGNSPVKRKAEPESGASLAKKMKAAEDGRNGVTTKVVENDVVEEIVSDIPGIGRTPSTQPLNAPSIESNSMDISSSNVSSNLPGGPNVMQNNNKSAEQQKQAIQEGYNKRKQEAKKNSMFMKKKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B1</accession>
    <name>I4Y7B1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960187.1">
        <property type="nucleotide sequence ID" value="XM_006960125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B1"/>
    <dbReference type="STRING" id="671144.I4Y7B1"/>
    <dbReference type="GeneID" id="18474455"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61312"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2039879_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7B1"/>
    <dbReference type="OMA" id="WRITYET"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="2">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="121" mass="12881" checksum="94E5130D8E4EEF47" modified="2012-09-05" version="1">MGSKVNKVVRAMPNSPCKIRADMMVVSALPCEWTSESDLILAISRSIGRCRFLGGKHFDACTALCRSIPTFAVTVLEATANGGVIMGLPRVEAVELPAQSLQGMARLILETSVHPATLNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V4</accession>
    <name>I4Y7V4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959975.1">
        <property type="nucleotide sequence ID" value="XM_006959913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V4"/>
    <dbReference type="GeneID" id="18474393"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61207"/>
    <dbReference type="eggNOG" id="ENOG502QWKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394939_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7V4"/>
    <dbReference type="OMA" id="FFAGHSD"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="698" mass="80142" checksum="76E33E47C326BB24" modified="2012-09-05" version="1">MYNSHFKLFIRAFQLTPKLSLSPSRMSSFSMSSRDNISTPPSSPPSFLHSPHKSTHRGSHGVASNYYTTLQATQSIIESSRYPTLDDDRLEFLKLEHSNLAYKVKLHTQRLLTELKVRDAMQVLGKLDQLDITQSSNKIDEVEKNLSRQRSRLLDVQTDLLHHNAGILAKYINNQKLLQPQSHHSQSHFDGRHFHANNDRAILPSNTSGSANKKSPLYEQRIQHLTTELDGERELNQATLAANESLQEQIETLKSQIYDGKNTTAETSQELMLASEKLNSALKETSKYQQLLQEAQSSNSRQVEHSNSLQNRLQSLLEDFSQIVTTRDGITSSIENLCNLLDTYKISYTKSSQNPLETFNSAISSIETQLMVVKEHSGMSEQMEYLTNEKHVMRQRFEYYENQVQQLSDVVANQKIDTEKQKQDFSSVIGEQKEKIAALEEQLGEANLRSKQLESDLSYYKDNNASYERELKLKEENKHNSGVSESEEKLSVQTLRALWKILPTSTQRDGNERLIESNSATLSQGDVDKLKQVLSRSKERTFEHFDLKTFVQRVKTLIDDNRLFLERILNNAETANLYKSNAEKAHKLALDFKTALEAYKRQVLDLQNNLSQASKRDAEIRKERESLREKISEMERNLSKQQQGSELDKLRKSLVNRDDEIQAFKQLQMDKSLGMLDELNSLQIEVADLRQKLRQKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Z6</accession>
    <name>I4Y7Z6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA/RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959809.1">
        <property type="nucleotide sequence ID" value="XM_006959747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Z6"/>
    <dbReference type="STRING" id="671144.I4Y7Z6"/>
    <dbReference type="GeneID" id="18473008"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58331"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580324_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Z6"/>
    <dbReference type="OMA" id="SCHRSID"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="471" mass="53684" checksum="E8DFE65561EAB5E3" modified="2012-09-05" version="1">MTIISIDFDAFYVACHRSRDKTLLNIPFAVQQKHILCTVSYEARARGVKKLSSLSDARRICPEIRTVNGEDLTLYRTISRDVFAFLVDYLGADTPIQKLGLDEFFIDISNLPGQPRESSQTHLVYQDNELTEDQLNDIAITADIRRQIYNRFKLTSSAGISNSIMLSKLVGNLHKPDQQTLLNVNNETELQNLLDAFHLRKIHGFGRVVVERIQKLTGLSDDETTVYNTRSRLQEDALINEFGEKLGTKLYKNLHGVDDEQVRQSSVYPKQISIEDSSGNIDTIDDAYKMLHSVTQRLVKRLDEEYLNIDKNGRKYFVMHPTKMRISTRRLSSIPNTRIASHFPESASCDIGVALFQIERNTVVERASRLCRDYLETSLTRLYRAGIAAGANKLRVVNVAFTDFVEGQPMKPIDDFMRGRKEIINLSSDSESENEGHISENNDDEIRCPTCNAQLMPFTVESHLRFHELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y806</accession>
    <name>I4Y806_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959819.1">
        <property type="nucleotide sequence ID" value="XM_006959757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y806"/>
    <dbReference type="GeneID" id="18474343"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61122"/>
    <dbReference type="HOGENOM" id="CLU_2147809_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y806"/>
    <dbReference type="OMA" id="CKAYDYG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="112" mass="12585" checksum="BF88167EAA213584" modified="2012-09-05" version="1">MYTKVHPGVCFVRQPTTSGFYLQNSELIANNTKLLHECRNGCETLDYGNKAWVVDSMKDVNVLIDECQNGTVSQATYMDTTLETSDGMIQRPKFTTLSALFIILLLIEFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y820</accession>
    <name>I4Y820_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959833.1">
        <property type="nucleotide sequence ID" value="XM_006959771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y820"/>
    <dbReference type="FunCoup" id="I4Y820">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y820"/>
    <dbReference type="GeneID" id="18474349"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61128"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y820"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="514"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="779" mass="87168" checksum="5A26D806AC70FF56" modified="2012-09-05" version="1">MPLEDPQEWENIGNVYYALTTLYKYHWNISSFEPYEIVTSGYSSTMAIYRNYSKLVPTTITNLPENTSNQPFIHIYSADGLHLSTISCTSPPIAVGFSSADELIVVLDDCQYKIYNYSGKIPTASTHRIAINSTGIADARITDDTIVVLTNEMEFYEMTLTSRPTKLSTMEIRDIPSDWTVIPSKYSQTSLTTIIAATEGDIQLSDSLSCMTHPFGTPHAQIKLSPNAKFIALLTPTLQLSIMTSDMARLLTTFDLSTIDSYTPDDIDWCGSNAVAVVYNEPSPHIWLIGPGGEHVLFPYHNATSIKAYSTPSSMLAITPEALDVIQKVPECVQDVLGATSSSPGRMLLSAFEELERGSSKSDDIIRDIGHDLLEAVDRVIGAAVELYTPEIQRRLLKAAQFGWQYLSNYNSDEFIKVASTLRVLNAYRDVGIPLSKAQCDKLEHVALIQLLLPRRKWAMAINISKHLQTPSDVVLVHWANAKIYASDHTIPDEELSVSIAERIASVTNTFVGWSDIAKVAYEVGRVSLATKMLDREPRASEVVPQLKRMKEDRLALLKAIQSSDPDLVIDVLLHLRSRLTLGDFFRVLEDGGSVYQLAKSLLVVYAKDKDRDMLRNFYFQDDRRVESAKLDLSEAEQLSGDAKVSKVKSAMKFFSEDKNCAFESKACDEYQKLLTITNGATSVNDAIRELLNKDDIKGAEKLKTDFKVSDKRWWYLRLHHLIGKSDYDGLEELASSKKSPIGYEPFVKALKKAGNKKLAGEYIKKCEPKRREELLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C5</accession>
    <name>I4Y8C5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_21012</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959705.1">
        <property type="nucleotide sequence ID" value="XM_006959643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C5"/>
    <dbReference type="STRING" id="671144.I4Y8C5"/>
    <dbReference type="GeneID" id="18470866"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21012"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8C5"/>
    <dbReference type="OMA" id="YERGYAM"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697487" description="Probable beta-glucosidase G" evidence="18">
        <location>
            <begin position="19"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="697"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="777" mass="85092" checksum="4152CD2B893F9BFA" modified="2012-09-05" version="1">MKLTQLLTLAVALTVVNARAVLNRQEKNPNNDNSIYPSPNANGGKAWSEAFKKAEDIVSQMSIEEKASLITSHEGRCVGTSPGVERLGIPQLCLMDGPTGPRPMKGVSQYPAGQTAAATWDKELIYERSKQMGQEFFDQGVHIALAPVASGPLGRSPLGGRNWEGSYPDPYANGVYSYLSVLGLQDSNVAATIKHWIGYEQETARHPYRTESTSDQNSIDSIIDDVTTHEVYMHPFAEAVRAGSAHVMCSYNRLNGTQACNNAYTQNHLLKTELNFQGSIISDWGGVHDSVDSALNGLDFSAPGVGFNGSMGTFWGELAELVNNGSVPEERLTDSAIRVLTPYFHFGQDSENIPPEVVFNGNSYFDAENVYKNVRADNTAELIRRLGSESATLLKNTGGLPLKNPEQIFALGSDLGDNALGVDGCGDAGTSCPEGNFNGTLTDAGGSGYAYAPYIITPLDALKQRTINGNIRLSYALTHDDELINEVAPSADATLVFINNWAQENRDRDDLQITIEQSNMLDAAVNASSNVIVVLHTPAVIDIEKWADNENVTAIVEAYLPGQESGNAIIPLLFGDENFSGKLPYTWGKTLDDYPPNGIVRDNDQSPQVEFTEGLFVDYKWFDKQEIEPRYEFGFGLSYTNFEFSDISVVDNYKEDDKEVQATNEPFEGFEEGKSLYDVIKTVTATVSNTGDVDGSEVAQLYVSIPGDEQPIRQLRGFEKVKNLKSGDSQEVSFDLRLKDLSVWDVTRQMWILPSGEYTFHVGNSSRNLPLSVTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E0</accession>
    <name>I4Y8E0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_20975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959720.1">
        <property type="nucleotide sequence ID" value="XM_006959658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E0"/>
    <dbReference type="STRING" id="671144.I4Y8E0"/>
    <dbReference type="GeneID" id="18470864"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20975"/>
    <dbReference type="eggNOG" id="ENOG502S4WM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095425_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8E0"/>
    <dbReference type="OMA" id="IDWTRIQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11774" checksum="C86228DCA2868159" modified="2012-09-05" version="1" fragment="single">VYFLSHILLIGSGCGVFLKKGAKILAFFIGAAFVFLQYMRSQGLIVVKWDNISRRYNASLKRKVGDNSTSDGVAVARVWNRLVDFLTADFQSRATFIAGLGLGLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8H6</accession>
    <name>I4Y8H6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_29800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959756.1">
        <property type="nucleotide sequence ID" value="XM_006959694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8H6"/>
    <dbReference type="FunCoup" id="I4Y8H6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8H6"/>
    <dbReference type="GeneID" id="18471115"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29800"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251308_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8H6"/>
    <dbReference type="OMA" id="CAVWIAD"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="197" mass="22242" checksum="1BAADAD88D426106" modified="2012-09-05" version="1">MADYWKSTAKYHCKYCDITINDDAPSRAQHENGLKHKGNKDKFIRNIYKRSQQDQKDRAFEERELRRLEGIGGAASSKETATGLKSSANKPPTNKRVTTNRDPYANYSTAKSLGYEDVPVTQEPTTAQQEAIVGGWEEVVIAPAVHKRPPSPPPNVEKEPDLNSVRGTPTSDIYIPGDNKNKEDKTEIKFKKRRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J5</accession>
    <name>I4Y8J5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_21043</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959775.1">
        <property type="nucleotide sequence ID" value="XM_006959713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J5"/>
    <dbReference type="FunCoup" id="I4Y8J5">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8J5"/>
    <dbReference type="GeneID" id="18470870"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21043"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8J5"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM20287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="40185" checksum="45CDCC69C13A1EBE" modified="2012-09-05" version="1">MSEKQIARERFQAVFSKISDECLQYLRDNQMPAEAVKWFDDNLQYNTPGGKLNRGMSVVDTYAILKGGELSDAEYEKAAILGWCIELLQAYFLVADDMMDGSITRRGQPCWYRQPQVGNIAINDAFMLEAAIYHILKLHFKKESYYGDLLELFHDITFKTELGQLVDLITADEEHVDLSKFSLEKHHYIVVYKTAFYSFYLPVALAMYMAGLSDEKQHQNALDVLIPLGEYFQVQDDYLDAFGKPEQIGKIGTDIEDNKCSWCVCIALQLANQDQRKTLDDNYGRKNPDQASKIKELYAELAIEDKFKSYEKDAHDRIVDLIEKIDESSGMRKQVYYAFLYKVFGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K0</accession>
    <name>I4Y8K0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_65644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959780.1">
        <property type="nucleotide sequence ID" value="XM_006959718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K0"/>
    <dbReference type="FunCoup" id="I4Y8K0">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8K0"/>
    <dbReference type="GeneID" id="18475041"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65644"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8K0"/>
    <dbReference type="OMA" id="DQERITH"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697495" evidence="6">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="40318" checksum="36B4C61D07E7EBB0" modified="2012-09-05" version="1">MKAVLSLLAVGASVQFTVAKEPWDNFKHIKAPLFADIVSFAHLKHQHCLLDKSEKFDIAVNGLPLDTSVSYRTGARFGPSGIRQGSRRQDPENAWSHYWKQNPYKRGIKVIDCGDVPVIAVDNNMAYKSIEAAHDTLLNRQPASKQLKHPMLLTFGGDHSVELPILRSLKKVYGPIALIQIDSHIDTWSSGKKYGFSDNHNEAPVSHGNMLWHAHEEGLLSSSIQAGIRTRFTNELDIEDNEKFGIEMLTIDAVDEMGTKGISERIKERIGDKPAYITFDIDSLDPAFAPATGTPEPGGLTTREAKAILRGLEGLNLVGADIVEVSPAYDTSAELTQMVAAEVAYELLNLLTTSPLMKTSVHHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L6</accession>
    <name>I4Y8L6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Formin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_29657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959565.1">
        <property type="nucleotide sequence ID" value="XM_006959503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L6"/>
    <dbReference type="FunCoup" id="I4Y8L6">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L6"/>
    <dbReference type="GeneID" id="18471106"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29657"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005825_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8L6"/>
    <dbReference type="OMA" id="RDEIFQD"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="77145" checksum="97B8122DA1808098" modified="2012-09-05" version="1">MSDSPAASHWTEHKATNGKIYWHNRVTKASSWVKPNEIKTRFDHAVDASEWGLNTVNDKIYWYNKTTKQSRWDMPEDLAQLKATFDAEDKAEAERKEAERIAEEKRIEEENRIAEEQRKKEELKASAQSPMLQIGYNGSQSGTPMLEGTGTPLAIGGPAAAPGLAAEVTPYEAKLALMDLFKQKGVAPDWTWEATIRELITSPVWKLEPSLSLKKDYFSEYIRKVVEDERAEKARRMDKLRPQFRDMLARTGRVHPYTKWSTLRAVIMTDPKLLKERSWQNCRDDNERKMLFDEYLKHIQKKEEDDERELRKNNIDKIMKYIETNKVAMDTKWPEFKRDLKSSREWRDDPDLQRVDMLDVLNIYEDNLVMAEKAWEARKKKMKTERKRDQRRKREAFTGLLKDLVKDGKIKHNTKWNDIIVDIKDDPRLFQIAGNSGSTALELFWDTVDEFQIHAEIVGQRVEDAFSMSNTKLSEEVSLNEFKRMVESNNVEIDWEGWSIEDIHNVITQKYLSQKREEKHQSERKRRIMIDDLRSAMRYLEPSLTVEDKFEDVLPRLKDLPEGKWLKDDDEACKIAFERFVKRLKDRSRDHGDSDHSRRRRDRRESVSQRERERERDERRAERRRSKSPHEEQREAKKPRKEEVEEGEMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N4</accession>
    <name>I4Y8N4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959583.1">
        <property type="nucleotide sequence ID" value="XM_006959521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N4"/>
    <dbReference type="GeneID" id="18472993"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58199"/>
    <dbReference type="eggNOG" id="ENOG502SBNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342307_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N4"/>
    <dbReference type="OMA" id="FEEEDCE"/>
    <dbReference type="OrthoDB" id="10655332at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="7">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="828" mass="93454" checksum="537A3F7A35D68E6D" modified="2012-09-05" version="1">MDSLSSWIVDWFKKYYKEYTWTGLQIENYPTKPKKLQLVEYRKLSRAGKPIEDNTDSSEFWWAIASDKRDKIPCYFTKSALENFETEAELRFTQLSGSIVFLRKWHAEIAIIEQQVEGGIKRKPHLYLIVDSFTYEGCLGEPVFGDPKDVMAEQLIVDFVRNQLRSGSSSLSAASLLRKSSIMRSRSETAQLSRNATQDEIEGSKSDEKPALEEKVKLEENKTSKEERIVHNPNKTLFRHSQWPLDFTLDEERCWMSEDQQQELARKGVFDPDAVREVNQSKVKPMGYEAYFTSQSISRTHAKSSHDAQAREEKMDIDSTGSTSEVAKPEVVHTSQSVPVSSLLLSNEPQISEKQPPKIPEEVFTRPQIATIRNNKEEHSRRDILPSSDNRSNLDKTPAPVLQSVSPGFFLPSAGDKSRESLQRVDTANQQSKQFNGSDTSMVTEEHSQAEVTRNLTKQNQEMEEQQPEPVSSTTMYAHWKESQLKMRRQAQVRTRSQSELKIVSQRAQQPEAEVVPQSDSYSKSQPGSQINSQPSQPSQLSLVSSEQPLPTPIPLHTSSSVVIEEDEDMEIRKPGKGVRMRHKSEQYKNIRKAPLKFSDDFDDELEHDEAFALDNTQSSNITNLPMSGHISSPYSSIPISGDNQTSNRIHSQGDIPPSSYSVVSIGSSIPNVVRDGSQMEPPNVSQIDPPIVSQEVSFRLSQSQFPPIAGDDGNDTAFFKATQEVADISHVPDSQEVINSRSNTNSNSNKSNNSNNSVSYPTPSQYKHQNRQILEDVFEHSQFKSQSVVLSPPLAQKLQKETIIFDQLPSCKHNRKAASERMLLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Y8</accession>
    <name>I4Y8Y8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding TFAR19-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959456.1">
        <property type="nucleotide sequence ID" value="XM_006959394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Y8"/>
    <dbReference type="FunCoup" id="I4Y8Y8">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Y8"/>
    <dbReference type="GeneID" id="18474246"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60915"/>
    <dbReference type="eggNOG" id="KOG3431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8Y8"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="122" mass="13572" checksum="FD02353F59280EE3" modified="2012-09-05" version="1">MADAELEAIRQARLQQLKQNQGGGDEKEGGVDEGKRMDLARILSAEARERLSRIALVKPEHADRVQDMLLKMAKSGQIRSQVTEQQLVGLLDQVSTVISGASTTKVTFNRKQNYDSDDDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y917</accession>
    <name>I4Y917_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_39869</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959485.1">
        <property type="nucleotide sequence ID" value="XM_006959423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y917"/>
    <dbReference type="FunCoup" id="I4Y917">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y917"/>
    <dbReference type="GeneID" id="18472134"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39869"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="InParanoid" id="I4Y917"/>
    <dbReference type="OMA" id="TPSEHIH"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="15">
        <location>
            <begin position="7"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="16">
        <location>
            <begin position="318"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 13">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="614" mass="68591" checksum="0498361A750C243B" modified="2012-09-05" version="1">MTTFKDSQIARVLGEKSFNRISSAKILIVGAGGIGCELLKNVVLTGFKNVHIIDLDTIDLSNLNRQFLFQARHIKRSKSEVAKETASKFNPDVDIVAHHDNIKAPQYDIRWFSQFDIVLGALDNLDARRHVNKMCLASNTPLIESGTTGYSGNVQVIIKDKFECYDCQVKPTPKTFPVCTIRSTPSAPIHTIVWSKSYLLPQVFGQAEEDDSELDKAADEGENADEINTLKEEQHAFKKVRQAVRTEGGAKVLFDKIFNSDVKRLLEMEDMWKNRQKPRPLEFDDCVNSSDFTTEGGTTDSAIVDQRKMTLGDNVKLFIDATERLSARARETDDPIEFDKDDRDTLDFVSAASNLRSIVYSIVPKTVFEVKEMAGNIIPAIATTNAIIAGVQLLKAVNVLNDEMDLCKPAVYLGSQLIAAPFEPPNPFCTACRDTYISLPVDESKLTLGEFITTLRMLFKVYEDDRELSIFEKERLLYDPDFEDNINKPLKDLGCQSNTFITVVDEDGEFDNVAVVLTPLPEDASESCILPSQDSFKQPGKRVKKPEPVEPEPEPVSRKRAREEEYTETADGVVCIDDSEDEAPPAKANNATITLDDSDDEVEVVPPSKKTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y918</accession>
    <name>I4Y918_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959486.1">
        <property type="nucleotide sequence ID" value="XM_006959424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y918"/>
    <dbReference type="STRING" id="671144.I4Y918"/>
    <dbReference type="GeneID" id="18474257"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60928"/>
    <dbReference type="eggNOG" id="ENOG502SN7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1289841_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y918"/>
    <dbReference type="OMA" id="RTAMICE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="214" mass="24231" checksum="0204481B03D658D6" modified="2012-09-05" version="1">MILRSGTLSRAMSCISQTNLSQLRCIHSKGEISNRDHRLQVGRAIRTLRLTLPRFFDDGLSDRVYGGEEEIYAPNVALYLPNFHTLHPPPLKGRAVYLRSASLLRLAFVALHSDAAVTLKSTHYYEGDLRISLMVSSINRLTRELSEWDVLFRYTFDNAGLIDVHEVLRINPPPTSSAIEGLRAVWMRLQHKPEEAVIFDGSGSNEDFHSKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A0</accession>
    <name>I4Y9A0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_20245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959312.1">
        <property type="nucleotide sequence ID" value="XM_006959250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A0"/>
    <dbReference type="FunCoup" id="I4Y9A0">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9A0"/>
    <dbReference type="GeneID" id="18470829"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20245"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="InParanoid" id="I4Y9A0"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="333"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="412" mass="46345" checksum="075B65A84FAFFE82" modified="2012-09-05" version="1">MSRYADINKVLEKPGPSTDEYFQAGDDVKKFLREQCKVLIIGAGGLGCEIVANLALTGFSDLHIIDMDTIDVSNLNRQFLFRSSDVGKSKAKAAAEFIMKRIPNVKVTAHHNKIQDFGEDFYMQFNIVVCGLDSVEARRWINATLYNMVDDDNPESLKPLIDGGTEGFKGQSRVILPTISSCYECSLDMLTPPTTFPICTIANTPRLPEHCIEWASVLEWPKVFPSKKLDNDDPEHIEWLLSKSLSRAKEFNIEGVNWSLVQGVVKNIIPSVASTNAIIAASCCNEAFKIATTTAPYLNNYMMFIGNEGVFTYTFEHQKRENCVVCGGESVDLEVKDEMIVEDLIDILKQRQDFQVRKPSLSNDQGNIYLQYPPQLEEYTRQNLTKPLSEYKGQTILVTDANLPFKLSLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A4</accession>
    <name>I4Y9A4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959340.1">
        <property type="nucleotide sequence ID" value="XM_006959278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A4"/>
    <dbReference type="GeneID" id="18472980"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58059"/>
    <dbReference type="eggNOG" id="ENOG502SDCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1994383_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9A4"/>
    <dbReference type="OMA" id="MHSPYKA"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="14352" checksum="634D9983DBA87BD8" modified="2012-09-05" version="1">MQSPYKARVRHYTDSGTGSPSNQRKDIENRKIADLEISNKALLAINHQLEQTRLKHVKQIKELKRLVEQLQLDRRSPSPQSMIDNVEEDDIEECLENDNQFNKIRWSIQDLIAQGKDALAAGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I3</accession>
    <name>I4Y9I3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_20327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959316.1">
        <property type="nucleotide sequence ID" value="XM_006959254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I3"/>
    <dbReference type="FunCoup" id="I4Y9I3">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9I3"/>
    <dbReference type="GeneID" id="18470833"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20327"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="InParanoid" id="I4Y9I3"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="477" mass="51438" checksum="293855BC22330D9E" modified="2012-09-05" version="1">MTESYTKEELNTIFKQFKSDKSNKVCFDCPAKNPTWASATYGIYICLDCSSIHRNMGVHLSFVRSINLDSWNTNQLRTMRCGGNQSAKDFFNKHSSGHLLSNSDVKAKYNSDVAKLYREELAKRVQKDQSDLPGKIYVPGSQSAPIDDTKAEDGDDFFANWDKPSSPATAPPAEPIAPPVIGMTTSQLSTPSVPSESTSPAPQSPAPSATPAAAAPRTISSASLRQSSSSSRPSKPSSKLGASKFGVKKAATPFNYDEAEKKAQLEVERLKTLELEAQKRAEEERAKQAAEAEANAAAAAIAAQNAEKARREAKAANAPVEKLEPRMAKLGFGQTVSFGANKSAATAAPTCLISYRSSYAAQVDDAPTTAREKFGGQKAISSDMYFERGNYDADERDAAQSRLKEFNGQSAISSDAYFGRERNSLDEDEDADEGLMGNGDTIQQLENTARDWAQRVAANPDVQQLGEGIRAGALKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W9</accession>
    <name>I4Y9W9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_20081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959176.1">
        <property type="nucleotide sequence ID" value="XM_006959114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W9"/>
    <dbReference type="FunCoup" id="I4Y9W9">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9W9"/>
    <dbReference type="GeneID" id="18470822"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20081"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080024_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9W9"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="250" mass="28728" checksum="FC552F344460A1A2" modified="2012-09-05" version="1" fragment="single">VGVDIRRHHVKTGKRTAPKSEDPYLLLLVRLFRFLARRTDSQFNKVVLRRLFMSKMNKPPLSISKLAYLSKNYPQAKQGATIVNVGPVTDDNRLLEVPKMSIAALRFTKTARARIEAAGGECLTLDQLALRAPTGSNVVLLRGKKTAREANRHFGFGPHKHKKPYTISKGRKFENARGRRKSRAFKVCSQLLLPALFLIKFFRYKLRFGYSTYGFFCTVDLQILKHPSFISFVPFREQERALLISYYHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB12</accession>
    <name>I4YB12_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_19471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958742.1">
        <property type="nucleotide sequence ID" value="XM_006958680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB12"/>
    <dbReference type="STRING" id="671144.I4YB12"/>
    <dbReference type="GeneID" id="18470800"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19471"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_1"/>
    <dbReference type="InParanoid" id="I4YB12"/>
    <dbReference type="OMA" id="YFSQAGQ"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="11618" checksum="AAFBA761C1685B98" modified="2012-09-05" version="1" fragment="single">MSEVEKQTTQNVESNAEPTVSQNLKVFVGNLPFSVKDDGLKDLCKDHGEITDAQIIRFGSRSKGFGFVDYATKEQAETAVKALNGQDYQGRTLVVEIARPKEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBP0</accession>
    <name>I4YBP0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_69219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958727.1">
        <property type="nucleotide sequence ID" value="XM_006958665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBP0"/>
    <dbReference type="FunCoup" id="I4YBP0">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBP0"/>
    <dbReference type="GeneID" id="18475548"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69219"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBP0"/>
    <dbReference type="OMA" id="NAYSMLR"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="943" mass="104409" checksum="20D3F1405B9F4E1D" modified="2012-09-05" version="1">MPSSTHTKKRLTYVLKENNNKTLLGIPDASARINRTFPLYSRLEEAMETSMTTLDKDDHPRHSLGVTTLALDTATQLSGKPGPEGILYTSGKDGLVASWQLGIQTRQRNRRYGTESPVEHFSEKFEIEREPQSAPIFRQCVQTHTDHCNDILLAMQNQVLISASSDRTVKAWRPHGDAQVPTVVGTHADFVKVLSHARDRHWIASGGLDRFARIWDLNQGGEVVRLPAQHSVYALTTNHSAGLLLTGTPSRAVNVWDPRSAKLVHNLDGHTDNIRSLLLSEDSTKALSASSDSTIKLWDLRNMSTIKTFEHHHDSVWSLFSQSPSLETFYSGDRQGRICKVVGEDVKDVATARHGITKLVASDDKLVVSASASSSSVSIWNDVDQKEQDDEEVDHDATPKLKTRAPSISSRISTRNDPLAVIRGRHGIIRALMLNNRRHVLTLNTQRHVSLWDIVTCVCVGQYTDEAVDAILGADEGADALTLTSQEVLERVRDKIEGQAVTNAWNSIDCQTGSLAVHLDESRCFDGEAYLDELGLAIENRETDQRVNLAKLVLTNLLRHFIDYEKKHIGDERPKPSPETNDKAYINQNAGTPTVGTPSGTPQIGVSRQLATPPATPALPPPALADPPPSERTTSSHSRGDYIAFEKKNEQQSGEKSAFLEASQNRPALVLRSPDNESVAETSSKKNETPDGSSSPALASPLLSSSPSNSRLGGLMGRMLISNSRRDKKESIKREESKESSPVITPIQMPESTNTMDSVKSRFKPATDDVTSIILNDNIPIGVSEETHDSEAFVSIYRGLVGTTGELGDVKHLEKSLPEWVLEMVLCNNVYKDPRTPKATFWLERHPDEKDLGGLPESGNRLTASRFLRARKLMNYVRDKLPADKTVSNEIPVEEQLELYCNNVKLDVTLTLGAIKSYIWQARRNDEPDDDSLIDPVIYYKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ9</accession>
    <name>I4YBQ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DWNN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_46009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958433.1">
        <property type="nucleotide sequence ID" value="XM_006958371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBQ9"/>
    <dbReference type="FunCoup" id="I4YBQ9">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBQ9"/>
    <dbReference type="GeneID" id="18472375"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46009"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBQ9"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="557" mass="62120" checksum="84A75BA846577285" modified="2012-09-05" version="1" fragment="single">MGSIYYKFKSSKNSSRVNIDGTSLSVFDLKREILLSNRMAINKGNDFDLVLLRDTPGQEEYHDDNEMIPRSTSVIVKRSPPKIANRGTAAKYIADAPLLSANESNPLSNIPKPPLASMSKRFDGKDDSRPQQQLMQSVSAFELNLFTPQPLQSENNNQGSEQDAISAMFAASEQQWEETQQHMSMATPVYNVRPPVRRPAPASTSNGDNTTSNPSSVPTQQLQSQAQMSSFTSTMPTPPGYVCYRCGEKGHWIQDCPTNGDPNYENKPRFKRTTGIPKSFLKTVDATTAASITNNGSNAAGVMITPDGSHVIATPDIATWEKSRAIKPVALTVNDIRESEPSDANLKCDLSGKLISNPIILPCCKKSYSEEYINQYLIENDFFCPNCHSNVGSLVNLSPNPPLKEKVVEYISQQLSLDRQKKDEEAKKNNQTDTKDEVEHTNKKGLFEDEINKINKLISDCQFAIMAIVEALNNKDLDDKLKFRFQTQLVQLNQILNLHQGQVMMMMNGMDPKVFGMPLLPELGRVDQNQQINIDEPLTNKKRSSADDDYNNSRPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBY7</accession>
    <name>I4YBY7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958508.1">
        <property type="nucleotide sequence ID" value="XM_006958446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBY7"/>
    <dbReference type="FunCoup" id="I4YBY7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBY7"/>
    <dbReference type="GeneID" id="18473953"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60453"/>
    <dbReference type="eggNOG" id="KOG4046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078577_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBY7"/>
    <dbReference type="OMA" id="IPKSECV"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="180" mass="20712" checksum="60B2906CB196E0D0" modified="2012-09-05" version="1" fragment="single">MSAAEKLLEERLNMNKEDASKIYSSKLENTTIMLENPLKSSKRKPTKSKLRRQTIRHSIKRTKMSYDVAKKLNRMWNEYINDLIDGDSMSIQSKMLKADLCGSAIKVIKSNNPTLINMEGICILETEQSFLIITPSSSQKSLPKNGGVFELKSDVFSLNLYADNFKYRNVDRLNKKFKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC94</accession>
    <name>I4YC94_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958283.1">
        <property type="nucleotide sequence ID" value="XM_006958221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC94"/>
    <dbReference type="FunCoup" id="I4YC94">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC94"/>
    <dbReference type="GeneID" id="18473892"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60333"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030437_1_0_1"/>
    <dbReference type="InParanoid" id="I4YC94"/>
    <dbReference type="OMA" id="VEYAYYK"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="371" mass="41287" checksum="FDC42A614752F685" modified="2012-09-05" version="1">MFIASRELPIIKPGRVPSINELVGAINNLRALYTSTVAGIKVSNPTQGVEGWSSITANDDGKNVYAHDIPVEYEVESDDDTFERRWSSNWLTRFIAISEEWMAEVEGTEEFNTRERVVEMAAAALACVAGMSAAGPIDRTFSFISRDRFDIVMHDKTINGHQDVGAQTWGAAVHLSRLICRHPEYFGIKSGARLLEVGAGTGLVGIVAAKVIEQLGYIDTTEIILSDYLDDIIENLRKNVHNNGSETKTSVIHLDWTEPDKGLGKFDTMYGADVCYDLNHAYLLHKAASELLSKEGTFHILIALRRTHIGMKESVQDAFSGKFVQPDGDALCIDKEDYFDVEKGLGRADETGYVRFEIRWKSKIFTSQNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ4</accession>
    <name>I4YCJ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958373.1">
        <property type="nucleotide sequence ID" value="XM_006958311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ4"/>
    <dbReference type="GeneID" id="18475495"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68940"/>
    <dbReference type="HOGENOM" id="CLU_1714726_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCJ4"/>
    <dbReference type="OMA" id="FRTLGVY"/>
    <dbReference type="OrthoDB" id="10403592at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="153" mass="16720" checksum="D6B144FAACFE531F" modified="2012-09-05" version="1">MAIIALFFPPLPAYIQTILLLCRYLAFSVTFPIVFLMLLDASAYVVFRTLGIYARRVRVVDKAGKSVAVDMIPPLSSTSNTPPKQKGTLKASFLDGINNESLNRRSINQNCLKTLANNLKLNSNELTAHQAANVPLPADADKGLNHRRPLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCM8</accession>
    <name>I4YCM8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_68966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958403.1">
        <property type="nucleotide sequence ID" value="XM_006958341.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YCM8">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCM8"/>
    <dbReference type="GeneID" id="18475502"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68966"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_1_1"/>
    <dbReference type="InParanoid" id="I4YCM8"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1375"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1644" mass="184476" checksum="3E37BC0362A8FF42" modified="2012-09-05" version="1">MATSSIHEIDVGRCTRLLKSLKAEINNFKNGVSHPPPADDPIYTPPSIEGLEILNHTFTIISQSSRDDNQFISALTDVKKSLPKPSSDAHVIDFGRVYLQPAGLYKGKDQMPARVRVAGKFKDASEGFIASLPTQIDDDEKDWLKANGFGYIKSDEESSIVRRVNGWVNATVALSTLSQSQSVADVVASARLITTPAPSNSIDNVDFQVVVTIKVFLKQKLLEQSPNDSLRLLLMRYSPPPQPSPNTPIRLSTQYFYSILKPANTPPNSVHTKALRTPLKQFQRKSIAFMQNREDNPDDIPEPGWMRLTDYWLYNAISGRLIEGTQPPNTSLKGSMLCEEMGLGKTVEILALVAKNAGRAKEWSKSQSSNYQRSVRTSLIVTPDHLLQQWIDEARDHTPGLRLLVYHGYKHMDTLLTAAKAANIASRLVGGGGAMSPSPSRSQSPPLPPPPPPKGEEQKVAQPTKSKARKKDDDDFVPQFSEHQLELFNSTGSRAQRDFLADGTRVERKTVTGATKRKAPRHTFDKFKELKECKHHALDFIDDIEGLFSFMDNHDDFDYETKSVLTNRQIVQDFFDEFDLIISTYSTLSKDLAVAHERQPRARRSGVEYRNDYIPMSPLVSCKFYRVAQDEIQLSGVKKSADMTALIPRQTSVACSGTPITGSIEQLLPILQYLGLHVDGRLIDKKSFASFATHGLSRDFARLIQSICIRTTKDHVKRQLQIPPLRRYIVPLHMGAAEQAYIDEQYKQALSEIGLTERGDFLDRSVTSVDITKLRTWITKLRQLTTHPQTSSATREGMGKTFRTVDQVLERMIEASSSHIVTEQRSALTSTVRIARLKLLMTPPERDEAKALLRRTVDEAVTVLASTQAQVDEHRIRKPKNVIEDVVAHTGAVVAIREKSDDIAETAEEAQARRDWQSHLTNLLGRHRDMLLVLHQAHLILGDIGHQQENQEEEDSNYAAADADRAKYLSHAIEIYNKRVDALSANLKRRIEPKKNDLHINYVGNTELGLDPSKVENARPSGEKKKEKPKKYAEVQEDEGEDEVEVDPEEKVTTTLLDLDILITKLNESTKFILDKRQKVLEGVLKSIDKVEASTEAYGEDAELQANLEIYLEAFESSIKDRREVLGLVDVSDDTGKGGKRRANANAKAREQLLLENAIEVEQDQHIDTEQDILRRQLQFERQGMRITKKDQSFRKLTSELKTWSTRIPKRNIKAFKELQSNLHDVYDKQRDLTRTLNLEKDDFLGTFNSRVLYFKQLQTLSDSVAPLDVESQEEGGKNIPQEIEESERLEAVSTRGIQSNRAKLNYLYHIRNASDESSNECAICTMSFTNGVITSCGHIFCQSCLNRWCQSRPECPHCRTHLSSSSLHKIKVNKPSDSKAEAKSEIGDDPGGNIVENTVDKRIRPQYNVISSEEMDDIEEQKIFTGGHGVKIDTLCKHILTLRAQNVKSVVFSSWQSGMQIVQRAFEKNDIAYTLGSDVKKLESFKKTNDVDVVLLNGERQSSGLNLTVASVVIFIDPIANFPLELQAIGRVDRMGQHQSVKVYTYTSLDTIDDAILDLAALKGQSLYVKDQDSASLSTNDMESLEKAQTKGDFIAKKDDLLSLLLPDVHIPSFTPSAKSRSESATASAFDSGSNVKIEEVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU7</accession>
    <name>I4YCU7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA/pantothenate metabolism flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_9733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958016.1">
        <property type="nucleotide sequence ID" value="XM_006957954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU7"/>
    <dbReference type="FunCoup" id="I4YCU7">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCU7"/>
    <dbReference type="GeneID" id="18475853"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9733"/>
    <dbReference type="eggNOG" id="KOG2728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042326_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCU7"/>
    <dbReference type="OMA" id="NTIRRCN"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="164"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="31494" checksum="24E7E2BF0390EC51" modified="2012-09-05" version="1" fragment="single">FSAQTYFDTQPEPHGHSQKISSVASFIDRQIKLKRRVALVTSGGTTVPLEKNTVRFLDNFSAGTRGATSAEYLLNDDRYSVIFMHRQHSLQPYTKHFSHTTNPFLDLLNLPNKPEDDITVNKSKTPEMFKILKRHNEVYEQDRLFSLPFVTVQEYLFLLRDVSKLMKKLGKNALYYLAAAVSDFFIPTQKIFEHKIQSQKGSLQIEMDQTPKILGSLVKDWTPEGYIVSFKLETDQSLLIPKAIAALEKYEHHLVIANDLKDRKYKVTLVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD83</accession>
    <name>I4YD83_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DExH box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958217.1">
        <property type="nucleotide sequence ID" value="XM_006958155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD83"/>
    <dbReference type="STRING" id="671144.I4YD83"/>
    <dbReference type="GeneID" id="18473874"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60304"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_1_1"/>
    <dbReference type="InParanoid" id="I4YD83"/>
    <dbReference type="OMA" id="WLQSDKH"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001714">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="284"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="939"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112473" checksum="443BB86C039459ED" modified="2012-09-05" version="1">MSKDLEFYNTNQQFDKIRQQRGSLPIFTQAEEVVTSINDNMITVLMAATGSGKTTQMPQLILDDAIQHGRGAKCNILCTQPRRIAAISVAQRVASERGEKLGKRVGYQVRFESKKPEPHGSITFCTTGVFLRRMQSALEESAGDSTEGKDKYGMLDDITHVVVDEVHERDVDTDLTLVVLKRLIADRKARGKPLKVILMSATIDSDLFQNYFASVNNDVPAPVADIPGRSFPVTKYFLDDYLEEMKTLPEKEGGWVFKEKNVMEYMKNEFKDEMGGDELEIPYPLVALTIAHVARLSRNEDGHILIFLPGWDEIKAVQTILEEQKLYGVDFNDRGKYSIHVLHSSVPVQEQQKIFEPCEEGIRRIILSTNVAETSVTIPDVVYVVDAARVKEKRYDAEKHMSQLVSAWVGKSNLNQRAGRAGRHREGEYYGVLSKRRYESLAAHQTVEMKRVDLSEVVLRVKALNFPGLEVEDVLAQAIEPPAPERVKLALDRLYLIGAINKKKELTSLGKVLLQLPIEAPIGKLILYATFFRCLDPALSLAAILTNRDPFVAPLDLRAEANAAKQKWSQREYKSDPFTILNAYETWWGLHSAGKHSQAWDFVNENFLSRATLLQIRQVKEHLYKSLESLKLTEFLTSDPALNKAKVGSQDKAKNLRKGELVIPDYLNVNAHSKPMLAALIAMSCSPNFALRTGDRNHRTAAEKSVFIHSSSVLHPRNEKDEVSYSKQLQYVNKHIVSFQEKTKNVSNLSAGPPGREPQVMLRMCTKLDLMVYALFGAAEIKQDGDQVIIDDWVVLFGQKKELESLRKLKMMLHSCMLRVFEGVHAGSALEQAEMYNDEEIYKLDNLLVLQSEEEAEQVNEEKLSPKEQVELDLMANNVVFLLNQWAKDANDYEDKVFGRKQINVTKKGNGAVNKKYASNPSSGTTTPNNQVKAILKRPASQTGSNSSAYGSNQSIHASKNTSLQSSRTNSAFPSRSNSSQNLTNSRSKNDKGMESSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB9</accession>
    <name>I4YDB9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_37391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957773.1">
        <property type="nucleotide sequence ID" value="XM_006957711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB9"/>
    <dbReference type="STRING" id="671144.I4YDB9"/>
    <dbReference type="GeneID" id="18472013"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37391"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005289_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDB9"/>
    <dbReference type="OMA" id="KGPYQLL"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121933" checksum="33401683FB6EBF1D" modified="2012-09-05" version="1">MNIEIAKQFKDLLEPFDRLVSNSVEASNTNDTSSSSSPSRKETVEERLDALFRKSNHNSSTQSLGPPPQIVTTRSSAGSSFKETTQASDRSAIKIKTISWNMADSLVNGDLEVLLGHVPPYTPPPSTTDKLPQLDREDAHPYHLVVVAGQECPTTANILPRGFSLALRDTNPKRETYNESSTDLLQQSQSPNLSTISQTNNNDPSSIQSGWSGILEQWFCHGAGTCQSPNIPPTPTEPIVNESLLSPPPMGDRKLSSTSVGSSTGMQPSSSANSATSQSQQAARPPMIKRHLSKSSRFEKDLSKQTNFNSGPYELLLKERLMGIYIAVFVFKGCRHLVENSSTAVVPAGLLGGRLGNKGAVGASVKIADTRLLFINSHLAAHEHRLAARLENMQKIQRSLAVDTFLPPDDPRNNKEDVTERFDFTWIMGDLNMRVDITRKHADWLIMNKDYKAALEFDQLRSVMKDGKGFNGFNEAEITFPPTFKYDVAKRSRTLRRRSWDNRSMNRTSTPDMSRPSLDSTAEFVEINDDDISSITSTSRSGNSSNVAKSPSMASSHLTSDVEDDSEGEDDEALRIAAINASQLEESKLFAGVDVDKAVDKAVENVKDAFRSLVKPISATSNDDKIRHRRSLESKRSSSRLSVDFSRRNASVFSDFDSRRNSFGGSHDQQHSVSKRRSSSSVTQESNLGRKPRNLSLDVNNLGVAQNGGPLSAGASPFSRSSFSRKLKQSLIRRSSQSSGSKHEDDLRNSAIDETASNDPDEDLKSTYDSSPKQRVPSWCDRILWRSTITPDAENLDRMRTKKFSKLGNAISHVLRRRSSSKGSLKEIGNSLSISNIAHHNRNNSNNSNSNNQTSQSHVQQLPVAETQIIEDNEAPRPKLHMSRSVEELSKVSPTTKVSFFTSSPMSTVKSEKKYREKDDKKKFLARFRSNSLGSPKDDDMLDASQVQKHMKSRKSFSWLETSAGRSSSDLLSPTEVIGSPSISPKTLSMTTNLNESSTSNSGKPKQEGSSQGNDGMQVSKWFVNSFPSLFGSRNPSNLLLDTGMNKTNSDTSTAANNQTPEVELAKQRGQVDCINYSSLTDQEMRKLEGRSDHRPVLGSFLAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDI3</accession>
    <name>I4YDI3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957833.1">
        <property type="nucleotide sequence ID" value="XM_006957771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDI3"/>
    <dbReference type="FunCoup" id="I4YDI3">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDI3"/>
    <dbReference type="GeneID" id="18475414"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68509"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="InParanoid" id="I4YDI3"/>
    <dbReference type="OMA" id="KQIMRAM"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="163" mass="17451" checksum="B5FCA9548F8E5039" modified="2012-09-05" version="1">MAACTKFVRSVLDNSLKNKGHDWSVYGALNGAHSVVSATPGYVHLKFHVDKHNLNRQGTLNGGCISSLIDSAGSLAVSSHGLFFTGVSTDITTTFVKPIPYNEVVDIFARTASMGRTMAFTRVDFCSPESGKLLAYGSHTKYIANSQGKDGNVTFSNDGENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL5</accession>
    <name>I4YDL5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_37543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957861.1">
        <property type="nucleotide sequence ID" value="XM_006957799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL5"/>
    <dbReference type="STRING" id="671144.I4YDL5"/>
    <dbReference type="GeneID" id="18472022"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37543"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_4_2_1"/>
    <dbReference type="InParanoid" id="I4YDL5"/>
    <dbReference type="OMA" id="KICRLDP"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="218" mass="24311" checksum="68918885DC185258" modified="2012-09-05" version="1">MSTSQTLIKSGQSLDDFLSTFWTSHLHQIEDEVTDFKKHELPLARIKKVMKSDPGVKMISAEAPILFSRACEIFISELTCRSWLVAESNKRRTLQKSDVSGAVELSDQFDFLIDIVPRSDESKKKGKNNAVESGNIQHQTYADDEAPVNDLQEVDQDEVSEGHFQQPLNYNEQQTNPANAAYLPYESDFLLNMIGSSPSHNQKPDNASEGSASDDASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDQ4</accession>
    <name>I4YDQ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957899.1">
        <property type="nucleotide sequence ID" value="XM_006957837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDQ4"/>
    <dbReference type="FunCoup" id="I4YDQ4">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDQ4"/>
    <dbReference type="GeneID" id="18473785"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60166"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072379_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDQ4"/>
    <dbReference type="OMA" id="AMNLKWA"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="71"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="239" mass="27751" checksum="CCF1A74715C6FC7B" modified="2012-09-05" version="1">MIKNLRLFSSSCRTQAVLGPKTSKKEVYRWESSKPDDNILPKLEIESKRRWLAYMRMEEFELPKLEKYRKEFKPPAKDEVVKVRTLDYLNQEPHPASVKSVVTVKVSDLPLADASSKHKLKLLAGPRWSGPESRIVDGKLVEDVDGEIKISSEQFPYRAQNMRWCSDKLQLLLKESNDKSYNFDDIPLDTRHVTRRIRKSRRGGHRLENLAGAQQGRRPTKFDMPESWIEEAKSALSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU6</accession>
    <name>I4YDU6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957938.1">
        <property type="nucleotide sequence ID" value="XM_006957876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU6"/>
    <dbReference type="GeneID" id="18473794"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60177"/>
    <dbReference type="HOGENOM" id="CLU_1846689_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDU6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="15574" checksum="D47C90DE1D1F3E3E" modified="2012-09-05" version="1">MMNEAIHRRSIMLAWTLDPAAQTALEYYITTLAMPHDLVHIVNVDTKGTGNLELELKERINQLETQVAEGIQVISHTLSGETSSALVEFADKYSPDMVVLGRRNLGHWKRIASDEGFSLSSHLATHIESPVVIVKFYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY8</accession>
    <name>I4YDY8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_37712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957977.1">
        <property type="nucleotide sequence ID" value="XM_006957915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY8"/>
    <dbReference type="STRING" id="671144.I4YDY8"/>
    <dbReference type="GeneID" id="18472031"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37712"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDY8"/>
    <dbReference type="OMA" id="FTVWFAP"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="498" mass="54116" checksum="F93195BDFA86781A" modified="2012-09-05" version="1">MKEYDAEKSSIYTEDSNKFKRHFNHFVDKSSKFGLEVRGIQPVTLEERTHGIGALLNIASIWLSANSTVLTLSTGGLGPSSFYLSARDSCLTILFFNLLGNLLPSYLGTFGPKLGMRQMCITRYSFGYYPVILVCLLNLIGMIGFCSLNAVSGGQVLSAVSNGSLNWNVGIVIIAVIALIVSFAGFKFLHTFERYAWMVITVMFIFVAGCAGRHLDAIYSVPFDPATPGAILSFGAVVLGYGMTWAPLASDFSAYLPPETKSWKVFLCNYIGLNLPLISLQCFGAIVQVGAMAIPEWTDGYEQNGLGGLLDAIMTPLKGFRKFVLVVLALGISSNNAPTIYSCSLTLQTFLPILLYVPRFLLSTLATGVYLPIAIVIATRFQEALNNFLSCLGYWTALFGSILIVDHLLFRKGNFASYDISQWDNPRGLPMGIAALIAGLIGCGIVVVSMAQIWWTGPLASAIDGGGDLATELGFVVSGLAYIPLKYIELLIEKRINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY9</accession>
    <name>I4YDY9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957978.1">
        <property type="nucleotide sequence ID" value="XM_006957916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY9"/>
    <dbReference type="STRING" id="671144.I4YDY9"/>
    <dbReference type="GeneID" id="18473805"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60196"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDY9"/>
    <dbReference type="OMA" id="ITYSEYD"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="186" mass="20592" checksum="A1343CD05D2DBDCF" modified="2012-09-05" version="1">MNPAILNLVVSLGLMQVARKIPFEDENVLLAVRIGYVASMAISFLVYQWIASKIRAKNDTTVLKYTEPASPMSQEEPQLITTTNRDYDLQETSKLIKGLFTSLAMMAFLHGYLKYTQPLFIQGILGVKNVFDSKPAKVWIFGNEAKGDLKRPWKAANPFGMGDDVKSDAASVKQAEKSIGSSNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE23</accession>
    <name>I4YE23_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_45420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958010.1">
        <property type="nucleotide sequence ID" value="XM_006957948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE23"/>
    <dbReference type="FunCoup" id="I4YE23">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE23"/>
    <dbReference type="GeneID" id="18472362"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45420"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="InParanoid" id="I4YE23"/>
    <dbReference type="OMA" id="LGGCQGT"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="467" mass="51552" checksum="191B4DFE8FA2AC19" modified="2012-09-05" version="1">MSFDPPDRPVSQLASLVPNQSITHFDTFKLESGIELKNVPVAYKTWGKLNDKKDNVMVICHALSGSADVEDWWGPLMGAGKAFDPSRYFIYCGNVIGSPYGTVSPVTANPDTGDLYGPEFPLSTIRDDVRLHKRVLDGMGVQAISSVIGGSMGGMQTLEWGMTFGYPYIRSIIPIATSVRHSAWCISWGEAQRQSIYSDPAYFDGFYYEHPDEKERAGPISGLGAARMAAMLTYRSRDSFEARFGRKPQLGQTGKKISSPFNDETQSNGSNSTSRPSSPAEEARDAHNDGNLRSRSSSSIPRPKNLFTAQSYLRYQGDKFTSRFDANCYIHLTRKMDTHDIAAEFDTNEPGVKVRSNGLSIDEALKLLPSNLLVIGIESDGLFTPFEQHQIGSAPSAELVMIPSPDGHDGFLLEFEAINEYVTKFLQNKLPEIYSSAPLLDLDEIKSFDTQKTSVFGEAEANDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE58</accession>
    <name>I4YE58_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_44591</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957514.1">
        <property type="nucleotide sequence ID" value="XM_006957452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE58"/>
    <dbReference type="FunCoup" id="I4YE58">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE58"/>
    <dbReference type="GeneID" id="18472336"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44591"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023050_1_0_1"/>
    <dbReference type="InParanoid" id="I4YE58"/>
    <dbReference type="OMA" id="CYQRKNE"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042325247" description="S-adenosylmethionine decarboxylase beta chain" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042325248" description="S-adenosylmethionine decarboxylase alpha chain" evidence="17">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="14">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="14">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="16">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="15">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="305" mass="34847" checksum="E5C8AD3D34854D36" modified="2012-09-05" version="1">MLDLVNCQVLSVINGQSNDAYLLSESSLFIAPHRLILKTCGTTTLLLGLERILEIAREVAHLDHVEQVFYSRKTFMFPERQRGPHRDWHQEVDVLNKYFDNGSAYTVGKMNGDHWLLYMSSKEEAIKPPPDSSPDTTLEILMTQLHPESCKDFYSVDGESGHLAGQKLSDKLGISKLFPDISLDAFLFQPCGYSSNATWTDGDNNDRYFTIHVTPEDGISYASFETNASYKNSAQLRDLVQRVVKIFNPGKLSSTLFVGTNDEEELDFRPSNEFSNRLLDNYKRTDRINYEFSGYELAYACYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE90</accession>
    <name>I4YE90_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_9562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957461.1">
        <property type="nucleotide sequence ID" value="XM_006957399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE90"/>
    <dbReference type="FunCoup" id="I4YE90">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE90"/>
    <dbReference type="GeneID" id="18475848"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9562"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2326320_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE90"/>
    <dbReference type="OMA" id="VECTYIR"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="12355" checksum="60796A3E327922DD" modified="2012-09-05" version="1" fragment="single">LVGLPVFLPNITFRLMRNHTPAGKEYNPYFATFRIPRSLTKQDIRSYLLAVYGVRSTWIHTDLYQPRLVRGMNMRWKRKGRGDATTGRGFYKRALVGLEEPFYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEJ5</accession>
    <name>I4YEJ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Rpd3p</name>
        <name evidence="16" type="ORF">WALSEDRAFT_60044</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957637.1">
        <property type="nucleotide sequence ID" value="XM_006957575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEJ5"/>
    <dbReference type="FunCoup" id="I4YEJ5">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEJ5"/>
    <dbReference type="GeneID" id="18473704"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60044"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="I4YEJ5"/>
    <dbReference type="OMA" id="GKIMEWY"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="379"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM22387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="448" mass="50859" checksum="025D04B73286A4F0" modified="2012-09-05" version="1">MFTPLENTRNKRVCYFHDTDIGHYHYGPGHPMKPTRVKMCHSLVMNYGLYKKMEIFRAKPATRKEMTQFHTDEYVDFLNRISPDNMDSYAKEQAKFNVGDDCPVFDGLFEYCSISAGGSMEGAARLSRNKTDIAINWAGGLHHAKKAEASGFCYINDIVLGILELLRYHDRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKFGEYFPGTGDLRDIGFGKGRKYSLNVPLRDGITDDNYKSIFEPVIGKVVEWYKPSAIVLQCGSDSLSGDKLGCFNLSMRGHANCVSFVKQFNLPLLMLGGGGYTIRNVSRAWAYETGLAAGQELSPTLPTTEYIDYFGPSYKLDVPSSNMEDLNTSAYLSNLKSAIFENLRDKDFAPSVQMQPIPRMNHDDDDDNKREDLDDPNERRPQRLWDKTIQRDDEFSDSEDEGEGGRRNEQSYAKAQPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEK1</accession>
    <name>I4YEK1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957642.1">
        <property type="nucleotide sequence ID" value="XM_006957580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEK1"/>
    <dbReference type="FunCoup" id="I4YEK1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEK1"/>
    <dbReference type="GeneID" id="18473707"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60047"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013516_3_0_1"/>
    <dbReference type="InParanoid" id="I4YEK1"/>
    <dbReference type="OMA" id="WEEQFKQ"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="608" mass="67472" checksum="A10479B8B194BCBB" modified="2012-09-05" version="1">MFGGGAECSTNSFNPLNNVLKNADVDRSVMKERPGLGTSSLSAFPKSSTSLREGDRLQHFGNSSPVAHHTGPFGMEAMRTEVGRLAPAASSSSSAWAHEFSGNQHHDIQRDLLERSFNQQHRNLSKSNWNEEYSQQQRGVSPGTSASPASLSHAASPSSSMYMQSPYMPISPSFAGTTQQTAPVNEAEENAKWDEQFDKMNEEISKKAAAVSEQSTATKEEDIQEQFKQTLRDEGLDVDNNQDYLAEFENVWNTQYAPHEDASNKNLASWEKQFNMEMNNARESIENDLIENQATSNPNQSVQTYQFETTNQYMESADPFAEGQRLLKEGGPLSEPALAFEAAARQSPHNAKAWLWLGYTHAMDEKEEAAIKALERCLNEDANELEAMIPLAISYTNEGDDNAATLTLEKWITRKYPSTLTPDTGTSTASNWPWATHQRVIDSFLNIARTQFSSTDKLDPDVQVGLGVLSYATSNYDQAQDCFKTALSMRPDDWLLWNRLGATLANGGNSESAIEAYTKALELRPTFTRAIHNLGVSCLNIGCYKEAVDHLLSAIALQQASNDRSINESQSLWQTLRRSLFAMDRHDLAAIAQPGTPVHKFKDHGFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF34</accession>
    <name>I4YF34_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957246.1">
        <property type="nucleotide sequence ID" value="XM_006957184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF34"/>
    <dbReference type="GeneID" id="18473581"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59840"/>
    <dbReference type="HOGENOM" id="CLU_1273135_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF34"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="25161" checksum="12201F90E32F3628" modified="2012-09-05" version="1">METNDFNDKLQLPVKTLYEDHNKNDWDMKVSQMAKTVSYSAMIFLVYYVINTLLTYLVYSYSKRKVAEIDYARDPSDMKALKSMKEPILYESTVSKIKKIIWLCFIIMVVSYLTSITYHPNSFLPDKRALNLKQAIWKEVSSVVLIFWISNTGWCAAATFCQILQYHLITGISMVGIISSMPFMNQCDKQRVENPDTPDHLYAVENLQHEQLIITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF63</accession>
    <name>I4YF63_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_68059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957274.1">
        <property type="nucleotide sequence ID" value="XM_006957212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF63"/>
    <dbReference type="STRING" id="671144.I4YF63"/>
    <dbReference type="GeneID" id="18475341"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68059"/>
    <dbReference type="eggNOG" id="ENOG502SCA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797941_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF63"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16111" checksum="3408781C001D461B" modified="2012-09-05" version="1">MSTPGVKEESEQYSLPPLNVLDSLQAMPQTVEPGMGMNPSIAPMPAQIPAGNQKARVRNLSANGPTVASQADDEKYILKFRDMKKKTKGLMTENDKLYLKLLKTQWDIKRAKMYKAILYERLQAAKEAQEAHEAQEGEEMSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF76</accession>
    <name>I4YF76_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957284.1">
        <property type="nucleotide sequence ID" value="XM_006957222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF76"/>
    <dbReference type="FunCoup" id="I4YF76">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF76"/>
    <dbReference type="GeneID" id="18473588"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59853"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="InParanoid" id="I4YF76"/>
    <dbReference type="OMA" id="NWYAVLP"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31798" checksum="A3B4DDE5740FEAB0" modified="2012-09-05" version="1">MAYFLGCQSKIDWNNQVVFLTGGSNGLGKSLVKELLVMRPKLIINVDIADNDITHERLQTINCDIADSTQLQSVCKTVIKEHGTPTVVILNAGAFDAKSLVDSTTRDFRNTLDVNFTSHLEILSAFLPGFIERNSGHIVSIASILGELHAAQAATYCASKAAVISLFQCLRVDLKHLHNARNVKTSLVLPGLIQTQLFGNVKHSKSSRLPSWLTDLALPSINPNDLARRIIVDLNTRRTGDIRSPYFVHGASWYYHLPQFVLDILEYVFMIILITSKPQSRKSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF86</accession>
    <name>I4YF86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_56808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957294.1">
        <property type="nucleotide sequence ID" value="XM_006957232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF86"/>
    <dbReference type="FunCoup" id="I4YF86">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF86"/>
    <dbReference type="GeneID" id="18472859"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56808"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_3_0_1"/>
    <dbReference type="InParanoid" id="I4YF86"/>
    <dbReference type="OMA" id="VCLKALW"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42359" checksum="623D137F215A63AE" modified="2012-09-05" version="1">MNYSFATDSSYEEHIQEIVGFLSRQLAENDKNNFIEIYQNKLIDLNQDKKVEILDSLLLDIKGLGLGSWSEIEGFFNLVGYLIVDLFEKSKVETTYKELINKLAITNSIDKKLLLYKVIYNLINNLSQEYSELRLESYKQLLELSIKNNDLQFVLQDYNLVSDLNDPHFFLTISNYYDQSNLNKESLDYLIKYLSFNENDNNQSKLLIKKVLEDKENFSLAQLLELKAIINVEQSTEFNLLSSIIKLNDDQFKKSIDQLDIDKEVVNHKYLLIKLNNYCSNFIGKDIAYDDISTNFRIEINRVELLLIELIKSGLTIARLNQSTKTFKVSHSNKLMIEQQDWLNIKTNLINIKSNLNKILNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFG0</accession>
    <name>I4YFG0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_63333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957365.1">
        <property type="nucleotide sequence ID" value="XM_006957303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFG0"/>
    <dbReference type="FunCoup" id="I4YFG0">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFG0"/>
    <dbReference type="GeneID" id="18474832"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63333"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFG0"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="17516" checksum="B876977C8465C69E" modified="2012-09-05" version="1">MPKIRTQRTKQPPEGFEAIEQILDDYSRKMRDVEAESIDGKRKNETLWPIMRISHTRSRYIYDLYYKRKQISKELYDWLLKQGYADANLIAKWKKQGYEKLCCTRCIQSRDMNYEGSTCICRVPKAHLKEGQTFECVHCGCRGCSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFP6</accession>
    <name>I4YFP6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957442.1">
        <property type="nucleotide sequence ID" value="XM_006957380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFP6"/>
    <dbReference type="STRING" id="671144.I4YFP6"/>
    <dbReference type="GeneID" id="18471394"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31938"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824399_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFP6"/>
    <dbReference type="OMA" id="DTHIRNS"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="39333" checksum="BC99EDF899C27ACC" modified="2012-09-05" version="1">MLPLYSYKHPSSYTTNGMRSPALAYTQSVQEANELIQALRGHVGFDMEWKVDFRKSAKQRRTAIVQLCDDKLILVLHLHHMSEIPNELIKLLTDKQRYKIGVNVSNDGRKFYNDFKIQLNSLLELTYLAKSIHSAELGSNRVLISLDKLTEFLLQERLDKGTERVGDWENKLNWKQIEYAANDVYASYQMFDKLSSQSTETNFDKFLVDKDYDKSSSALKEIPNNDKIISNSGKVIYNRVIRSLTKDNVTLTYLQPRHIKTLKWYFENQRSLDQTRNELRPEKPLARITVILYATEILLLSKKGYSDAMLVKLQNDIEKYLDVSIKKSWYEDYGCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFW5</accession>
    <name>I4YFW5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956906.1">
        <property type="nucleotide sequence ID" value="XM_006956844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFW5"/>
    <dbReference type="FunCoup" id="I4YFW5">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFW5"/>
    <dbReference type="GeneID" id="18473476"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59648"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="InParanoid" id="I4YFW5"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697672" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="210" mass="24335" checksum="29F4F18120AB7691" modified="2012-09-05" version="1">MRYLAAFLVIISTLSVVLSSALTTTIEAAERSCFYANVDKKGEKIGFYFAVQSGGNFDIDWEVIDPEGNVVVHGEKERQGDFIFTGNHYGEYKFCFYNRLSSMEEKLVDFDILVESEPRHELPKKTKYLQDSTQSLEDSLYKIQGQVSTLQRNQRYFRTRENRNISTVNSTKRRLKSYAIFETLAVILMSCAQVWIVKNFFNMSSTRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG59</accession>
    <name>I4YG59_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_56619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956996.1">
        <property type="nucleotide sequence ID" value="XM_006956934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG59"/>
    <dbReference type="STRING" id="671144.I4YG59"/>
    <dbReference type="GeneID" id="18472833"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56619"/>
    <dbReference type="HOGENOM" id="CLU_1009026_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG59"/>
    <dbReference type="OMA" id="ATGEHIN"/>
    <dbReference type="OrthoDB" id="10607997at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="276" mass="30295" checksum="7BC38026FD2A7FCC" modified="2012-09-05" version="1">MSDENTSSLLDKWIKDDNMIVTSKMLSREIGSRPNIAKNHLLAYYNSNENTVHPVIAISGRTNSASLQTHLTANLDRLEETKKMFIDISSIYLHAISASKITDLTMIVNYEKEYFQHSAPAPSNLPKKAKPAAAPAKKTAPSAVKKEIPKKEEKDAVKPKAKPANGKRRIIESDDEDDITISSPADAPPLAQTHTQAPERMDKKRKVTKSVTKMNEKGYMVTEDVDEWVTDDEAPPPKKTAAAGNASTKPKSKPAASAQAKPKAGQSSLNSFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD2</accession>
    <name>I4YGD2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_9207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956839.1">
        <property type="nucleotide sequence ID" value="XM_006956777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD2"/>
    <dbReference type="GeneID" id="18475847"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9207"/>
    <dbReference type="eggNOG" id="ENOG502QQMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2729389_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGD2"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="72" mass="7845" checksum="7491D931F614368E" modified="2012-09-05" version="1" fragment="single">FGHLVHAQTTQGLAKRLDDPRPGDVLVLRHAEFKGRKALGNYKASFGAHGPQVAFVTEYDLKKGKVTAIQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE3</accession>
    <name>I4YGE3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957072.1">
        <property type="nucleotide sequence ID" value="XM_006957010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE3"/>
    <dbReference type="FunCoup" id="I4YGE3">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGE3"/>
    <dbReference type="GeneID" id="18473528"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59741"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="I4YGE3"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="39665" checksum="A338EE71D0698819" modified="2012-09-05" version="1">MTLQQCQYKTGEVLGSGSYSSVKLAVHIKTGEKYAVKVINKKMMEGREDLIRNEIAVLKRASTGHHNIVRLIDYFETMNNLYLVMDLCTGGELFDEICQRGHFFEKDAKDIIAVIADSVSYLHSTGIVHRDLKPENLLFRNDKATPNDLCVADFGLSKIIESGKFTQLYQICGTVGYMAPEVFMRVGHGFPVDIWAIGVITFFLLSGTTPFDRGNQKEEINAILDGNYKFEPAEYWNAVSETAKDFIKGCMNTDPAKRLTAKQVLEHPWLKGLGEKDEDLLPNVRRAFDAKRSFRAAVRSVQWINRLRSLDSSEEEKEEYRQQVFALQQEAEKEVLGPESEVTMHAIPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGF4</accession>
    <name>I4YGF4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957082.1">
        <property type="nucleotide sequence ID" value="XM_006957020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGF4"/>
    <dbReference type="GeneID" id="18473531"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59747"/>
    <dbReference type="HOGENOM" id="CLU_1300545_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGF4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24247" checksum="21CFE28A9DAF7CB5" modified="2012-09-05" version="1">MLKNNLLGVILENTTISDLNLDILNDKLNLNNKYFTADVDIRVANVEEYMDIDYTDLDALLVVFRSFDNLSVDFLKKVKEIQIDSKLALCLDNNSNDDELDNHFINYDVEYITSNERLLDALSSVGWQSLQLKSDDRNKGDAEDTIQDTNEDSTNDSYESFDQLLSKLNYYKSQLSQIDNIEQRHEYASILAQDMASFIGDDDGADIDDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGQ3</accession>
    <name>I4YGQ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956543.1">
        <property type="nucleotide sequence ID" value="XM_006956481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGQ3"/>
    <dbReference type="STRING" id="671144.I4YGQ3"/>
    <dbReference type="GeneID" id="18472798"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56330"/>
    <dbReference type="eggNOG" id="ENOG502QWKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002951_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGQ3"/>
    <dbReference type="OMA" id="HIRVQVE"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132618" checksum="66DC43F8B5C78762" modified="2012-09-05" version="1">MSVNWQNKLRQAEIDSHQSWLDDLEELFVNAHQRFSDISWSTQNEDEEIVHAHKAILYARAPSQFLSAYLPKQPNTLDTQDNSSSLNVAVASTLQRSPSPTPNSLILPKSTSPAILSSALKFLYTANDGESFDFLFDQPLVDRQNQDERQAKMRSDLVYMWRSTLFSDVKITLVDDTGEALKKHDSDDDDVDDGEAIFSAHRALLASRSTYFANILSPTTGFIESLQNADSGPRSVTLHQPPFTPASLHFALGYIYSGTVAFSNRTLDLSTAFEVYEAAEYLDLTPLKAQIVGKISEMVNYFDFPFTANRQLLIKRIPRILEFTLRPTINEPELEASVFELCVKGFGDIWGKDIAELPYPTRKQLVSSVNLGISSHTLIPALKAVIAIQNRLKNEMRFAKWVNELTNMVNAVDKHIRRCLDANLGEVLDSDKFWDLVDGVGFSNDAFEKLLEMIIESLNDENCIFSYQSFTSKILRNENENRVLTPSMREWCDEIRKKIVKSVRSRWMNVKSLGLFEKLEKWCLQELSEELGVGVDELLPPKQTTRRFVKKSTSSVRKEDDGTDLRTNVLRNTGRRATSTMNARPPRAQTQSTSVATTSHQTPPKAVIPPRRAGSLNTTMSAASTTPTTVRSGRSPAQSGSPNSRYPGGRRPIAQSSSASISPSMRSAASAASRASSTTTYSKNNAETQNSPSVVRSKPKTGSQIPKPSSTPRTTTPSISSNRSANINRRMSTPSPSPSLIPTHTMRMRRISTPSKTTRGDGDMMKQQLSDKEKGKDNVKKKAEGSVKESQEKDISGNTKNEPEDSSVIGLRKEKLPSHIQKTNQGGPRLRPRPHSQSGNSVRSLAAKFESNSGDSKLGPRPSSVTPIVEQDTKKDMVEDSKESNKEDAKEGGKEVAPEVTQSEKSDKENTNLSSLETPQKKPKSTVGRLRSGTLRQHENPLEDANATPRAVLQSESGNKSPTNSEHRLSNLSLVGGLGEGESDPESVAPSRIPSLSLTERSLTTQKSMMSLVEHDPDQGKEQQCTTQETAPKMVIKEQKTVEPHGVALTVGIPCIVACKPKRRKSGASIRFRALVRYLGTIANEFGPWVGVEIPSEEITEEKFNSVSGWNDGMLHEKRYFSLQGEKWNAMEPRRSLTIPSEVGGKSRVPKRSISSSTRAVSGMSSLSETSPIEEDKKTQPHKALFVRPANVVWVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGT2</accession>
    <name>I4YGT2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="10">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIM1</name>
        <name evidence="15" type="ORF">WALSEDRAFT_43166</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="10"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956568.1">
        <property type="nucleotide sequence ID" value="XM_006956506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGT2"/>
    <dbReference type="FunCoup" id="I4YGT2">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGT2"/>
    <dbReference type="GeneID" id="18472274"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43166"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGT2"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000184">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="120"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="921"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="770"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="833"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1009"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1052"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="557"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125070" checksum="CFE22AAF082A7CF2" modified="2012-09-05" version="1">MLRLTTRRILRRSHSTLYKAIPNSRPLSTTPHLGPRWINDKPRARLSTQRRGGAPESSALEKKAELSADDAKSNDAASSSNAGATSGGNSGGNDNEDDNSSSNKSTSLTKNTPPSYFPRVLALPINRRPLFPGFYKAVVIKNPQVVSAIKEMMQRGQPYLGAFLHKDPDSESDVINSMDECEDVGVFAQITSAFPTRTSKSDDDKESGNNNNNNNNDQEESLTAVLYPHRRIRIDELYAPGVKPPKPRLPSVEDARDQLPQEVKEASPEEEKQLEEAHKERRKAEQSHPLQTAFLEPFNISLVDVTHLKIPPATKPHSQTTKALMSELINVFKDIAQLNPLFRDQIANFSVSQSASNIFEEPDKLADFAAAVSQGEISELQAVLEAENVEDRLGKALVVLKRELINAQLQSKISRDVESKIQKRQREFYLMEQLKGIKRELGLESDGKDKMLEKFKSKSSSLAIPEPVRKVIDEEISKLSTLEQASSEFAVTRNYLDWLTSIPWGQHSTENFSLPHATKVLDEDHYGLKDVKDRILEFLAVGKLRGSVEGKIICLVGPPGVGKTSIGKSVARALGRQFFRFSVGGLTDVAEIKGHRRTYVGAMPGKIVQALKKVQTENPLVLIDEIDKVGKGYNGDPSSALLEMLDPEQNNQFLDHYLDVPLDLSKVLFVSTANVLDTVPAPLLDRMEVIEVSGYVADEKAAIAERYLAPQAKESSGLKDADVTLSPEAIETLIRSYARESGVRNLKKHIEKIYRKAALGIVKDLGEESLPEDKAQDLEKTTTIPSETPKPNEVQATSSSSTTATEPTSSTSSSQQSLQKTSKNILSNFFSSSAEPAKVSAKSNNESKSQLEDNKTPEVSNNDQSRSKESTPEEGETTRVSSQPRKPLEIPSTVSLKITPDNLSDYVGPAIYQKDRLYSQLPPAGVSTGLGYLGNGSGAVMPIESRLYSGKGSLQLTGKLGEVIRESAQIALSFIKSNANQLGLDKDVFKDRDLHLHMPEGAIGKDGPSAGTAITTALVSLLTGLKVDPDLAMTGEITLVGQICAVGGLREKLLAAKRAGVKRVLIPQACKADVDANVPQSVKEGLDLVFVEEYNEVLKYAFGSSHHLAKHWEDNGLMVDRNVRHIHTSTPPPSTSNEIRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGY9</accession>
    <name>I4YGY9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956623.1">
        <property type="nucleotide sequence ID" value="XM_006956561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGY9"/>
    <dbReference type="STRING" id="671144.I4YGY9"/>
    <dbReference type="GeneID" id="18473394"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59508"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050705_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGY9"/>
    <dbReference type="OMA" id="RIVCSFH"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="284" mass="31057" checksum="5066699D32393C72" modified="2012-09-05" version="1">MTSEIHSNTLVFTNLPTNIFQSRILNILKQAIESYAISSENKLYSWVALPSFSRAIAIFWDAGDAALCKDRLDRLAIGKQHNHNRDNGPRLPKRQRARSDCPPLASDWNTGFLLRVFSLPPTPITGKELDNLHLSVPGIEKNFLISPPGSPPVGWEPIVEDPPNTETLAEDLVAALESIKHDETAGEADSGDNIKTEQLPGLTPQFLLTPQRDVPGVSIANYTDTSSLTKDNETSSSLPTKATSESMAGRKRTHSRTPSLCVPSDSEDIMRSPTTITPTARPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH40</accession>
    <name>I4YH40_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956672.1">
        <property type="nucleotide sequence ID" value="XM_006956610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH40"/>
    <dbReference type="FunCoup" id="I4YH40">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH40"/>
    <dbReference type="GeneID" id="18473415"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59538"/>
    <dbReference type="eggNOG" id="KOG1504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_0_1"/>
    <dbReference type="InParanoid" id="I4YH40"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="173"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="36793" checksum="1F0109FCA9467EEA" modified="2012-09-05" version="1">MKFTGRLTKQLPHLLSTGDLSKQQLNTLLKHSAELKDAFKKNAIPPAKLSIPKSLDAKTVAVLFNKRSTRTRVAAETSLQALGGHPLFLSPSDIQLGVNESLEDTARVVSSMTDGIFARVGAHSEIETLAKYSSVPVINALSDLYHPTQILADLLTISEVYGVNYSSEAPLSGLTFSWVGDANNIINDTLLSLPRLGAIVKVGCPQGYEIDNIIIKQLEEQGILDKVLFTSSPLEAVKDADVIVTDTWISMGQEDEKTKRLNDFKGFQVTEELARKGGAKDNWIFMHCLPRKTEEVDDHVFYGARSKVFQEAENRKWTIMSIFDKILGEYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH48</accession>
    <name>I4YH48_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_43352</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956678.1">
        <property type="nucleotide sequence ID" value="XM_006956616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH48"/>
    <dbReference type="FunCoup" id="I4YH48">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="18472281"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43352"/>
    <dbReference type="eggNOG" id="ENOG502QS0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007861_1_0_1"/>
    <dbReference type="InParanoid" id="I4YH48"/>
    <dbReference type="OMA" id="WTPEQAW"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="785" mass="87925" checksum="0AD881D4942B149F" modified="2012-09-05" version="1">MRRLFSTAVGESNKIYVSSIFPIRYGRFDPRYAYSLMREHSILDYLRSRMNESGVQVKSIDSRLREGGAFVTVEDNASLSARTLRNRLIDNGSLRKVTLLNSAIFPVLGCPFNEDMDRYPSSQLKVDFEGEDVSQEDIYGLFRGYGRIVEIESIKNGAIITYQATSASTAARSCLHGVMTSGTRLRISYQARVSKHFYKDWIVSHPRIIAPLLVFLLGAISYVIFDPVREYAIKSKIMQTFSLDSFKRKLLMFGDGSIKSGNENIIGSDIQDRKEASELASVWLNESPSTFITVTGARGSGKSSLLKHITHDRQVLQIDCATICKAENDTQLVTALAMQTGYWPIFGFLSSVSNLLDLASVGLIGTKAGFATPLEEQLKQILTLTTKAIEKASNSKFSTSKSEHDYLVSGLRKQAENEVRSNTSSFKHDGRLDCLAGNGVMSELGVGLENDEIDDRVFSLALSRLENISNKDYDEEKEKVKSIPVVFVKNFDYKGADKDILFEVISSWAANLITSKTAHVIFVSDNVSVNKRLNKALPNKPLNSISLSDADKKNSLKFVTNRLTNINLNNDDRKLIELIGGRVEDLEDLVRKVRSGLSVHEAINQLVTISASELRQNILVKNEHGWSPEEAWLLITELSKGEKVSYASTLIDWPFKGNEAALQALEQHDLIAITHKNGRPADIVPGKPIYRTAFKQLVNDAPYRALQDVTSNKLKREYKEGQIRKWENELLDLKNIGLSDSSFLSSFKSPQATQLRAEYLMRQIHSAQLTVNKLEKDSDKLKKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH80</accession>
    <name>I4YH80_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956708.1">
        <property type="nucleotide sequence ID" value="XM_006956646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH80"/>
    <dbReference type="GeneID" id="18475269"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67593"/>
    <dbReference type="HOGENOM" id="CLU_1016367_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH80"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="31520" checksum="BFABA73C42A4AB9A" modified="2012-09-05" version="1">MQNEDVIDWGDDIDESADVISLTGYEGEDNTNTTEIAGESAKATTSKSTATDINLIAFDGPRLDNKWILRISSVGEPYFYNSIDKMSVWRCPGFTQPATESAEKKRKLQSQQSLQRDDSVASQKAPLEDKRTQQQEAQKVQKVQQPPPQRPQPQTRPQPVQAQKQPKQTYQVATDKDQHEQRSEAGQRYYSNRSSNPNSRRLPEKPQTYGEKLSNRISNNRAQDKQPGYYNRGYAPDNRRYQQRRADEGSGGYYHNDNYDREKELRQQIKNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE4</accession>
    <name>I4YHE4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31478</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956766.1">
        <property type="nucleotide sequence ID" value="XM_006956704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE4"/>
    <dbReference type="FunCoup" id="I4YHE4">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="GeneID" id="18471310"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31478"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="InParanoid" id="I4YHE4"/>
    <dbReference type="OMA" id="LVFYIRH"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="304"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="588" mass="67230" checksum="34E127E52092CF13" modified="2012-09-05" version="1">MAVCVKEFVSHCPSSSERKTLTANTDSWYKAPKWALGVAMCFTAILIVVMIIQAIKYISLSSRRLMKGGSLSIFNRTAAISRALHYHRFRVRSYLLPYTFPLILVTFMFVWTTIWCFATLPYYRAGTEWGSPPLGVRAGYIGTALVPLVFALGARNNPITFFTGIPSEKLQIYHQYGARIILFFSIVHTIPFIVQPYQQGLQLGGSREVARYFLKYYYDQTEQFWNGIPPFVALIWIVLSSMGYFRRFSYEFFVIQHVLSILFFLAWMFVHCQVSLMDAWYYLFVSVGVLIWSWFGRVLWSFWANDFNINQATLVPLSEDVTRIRIITPLRWKPAQHVYIRFPTMFVFQSHPFTITSIPSLDVHNNSNIMQLLIRGKGGITKRLHEKARNGITSIPCFIDGPYGGMLAPLDNYTNVLLLSGGTGVNAVSGILLDLMRKMERGETLIQHIDFIWTIRSISSIEWFNETFKALSMYSCFSNVNIVVHVTGSDPQESITLEKDESRHSSESGMYDEKLYNFTKGRPNLQDIVRKSANASQGRDLGVVVCGPPQSMFNYEVMNECAAIELKIAAGDETLPRRLFAHSEAFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE6</accession>
    <name>I4YHE6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_43481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956768.1">
        <property type="nucleotide sequence ID" value="XM_006956706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE6"/>
    <dbReference type="FunCoup" id="I4YHE6">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHE6"/>
    <dbReference type="GeneID" id="18472292"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43481"/>
    <dbReference type="eggNOG" id="ENOG502SBZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144297_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHE6"/>
    <dbReference type="OMA" id="FMKWRRK"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="11286" checksum="B85E0AC3A1B4A4DD" modified="2012-09-05" version="1">MYRNIIQRRLLSTTRVSFDAPKSSCIAGTPLPGLQILKDDPEKVAREDEAYPDWLWTILEPRDLSTQGDQTFNAAQERKNINKQHKIDIKAKNFLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHI9</accession>
    <name>I4YHI9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956806.1">
        <property type="nucleotide sequence ID" value="XM_006956744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHI9"/>
    <dbReference type="FunCoup" id="I4YHI9">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHI9"/>
    <dbReference type="MEROPS" id="M67.A13"/>
    <dbReference type="GeneID" id="18473452"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59607"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053034_0_2_1"/>
    <dbReference type="InParanoid" id="I4YHI9"/>
    <dbReference type="OMA" id="VKMKLFQ"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="348" mass="39216" checksum="741ABCFB6F997F79" modified="2012-09-05" version="1">MDSSVAMKTFDLENDVEEVDLIYTYDEDAQRDINNKRPWKQDPHYFKRVKISTVALIKMVLHARSGVPYEVMGLMQGKLEGDTMIIMDAFALPVQGTETRVNASSEANEFMVNWLNGSKSVNKPENALGWYHSHPGYGCWLSGIDVTTQSTNQQFQDPWVAVVIDPNRTISAGRVDIGAFRTYPQGYMPPKSTSIDQNIPQSKIEDFGVHANAYYQLEVSIFKSSLDKKLLDLLWNKYWVNTLSQSKLITNRAYLTDQISDLQDKLKEAEMGLYGRGNAEKSDDDSGLVKAVRLSNRIAVEGQLGLISQMAKDALFNRSGCTHNHDKLRASADTVSRLNTEQTEPMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL3</accession>
    <name>I4YHL3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_35981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956827.1">
        <property type="nucleotide sequence ID" value="XM_006956765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL3"/>
    <dbReference type="FunCoup" id="I4YHL3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHL3"/>
    <dbReference type="GeneID" id="18471938"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35981"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014848_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHL3"/>
    <dbReference type="OMA" id="GHVMFRT"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="49"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="42204" checksum="24DE64C3A39AF528" modified="2012-09-05" version="1">MLSLKEMDRIEKWRDMLQPKHRDIGSNVRLWRLKAKLNETTLAKRLVKGVPDRWRAAAWESILLRNIEKEGEFPRPLYSQNVSGSSDKMSMKSGFRPASTRSISTIGEETNESLSSSEQINKSTMDRLTKEYFDKQSEPSSYDIQIDLDVPRTISGHFLFHNRYGLGQRNLFHVLHAFSLQDNGYCQGMGPIAATLLCYYEPEKAYAMITLLDRHYGMHEVFKHGFPGLLEHLHVQDEIVKLTMPKVYEKLDQENVPPTSYATKWYITLFANTVPFKTQLRFWDMLMFYGPDAIVAFSISILWSLRHNIIEKNSNFETILTSLSNFFIPEDEDTLMSVCSSILNDAQIRTEMDRSRENYRSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHL7</accession>
    <name>I4YHL7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial cytochrome c oxidase subunit VIa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956830.1">
        <property type="nucleotide sequence ID" value="XM_006956768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHL7"/>
    <dbReference type="FunCoup" id="I4YHL7">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHL7"/>
    <dbReference type="GeneID" id="18473458"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59620"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_2_1"/>
    <dbReference type="InParanoid" id="I4YHL7"/>
    <dbReference type="OMA" id="KLPWMVD"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14790" checksum="085956047E3BC5F6" modified="2012-09-05" version="1">MFARRALRLPVQAQRRHASSSASRGADGIVVPMEGQSEFITKRAATTEHAHESSELWRKISLYVALPGCLLGGLWTKNLEEAHEAHHHHIVEQNGGEEPEKIPYPYLRKLEKKFPWGDGEKPLFNTLLGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ6</accession>
    <name>I4YHQ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_59236</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956176.1">
        <property type="nucleotide sequence ID" value="XM_006956114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ6"/>
    <dbReference type="FunCoup" id="I4YHQ6">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHQ6"/>
    <dbReference type="GeneID" id="18473239"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59236"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHQ6"/>
    <dbReference type="OMA" id="HFVNFQR"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="181"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM23498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="649" mass="73321" checksum="262D22F9085B6D6C" modified="2012-09-05" version="1">MSNRVAHSFDKAKLEAVCLRRFFFAPAFEIYGGCAGLYDYGPPGSALQANILDAWRKHFIIEEEMLEVDTTAVTLGEVLKTSGHVDKFTDWMTRDTKTGDIFRADHLIEAVLEARLKGDKEARGVQQTEQPKEDEKKKKKKVKSTAVKLDDAVVQQYETILAQIDNFDGEGLADLIAKHTIKSPETQNDLTKPVEFNLMFESSIGPTGQVKGYLRPETAQGHFVNFARLLEFNNGRVPFASAQIGKSFRNEISPKQGLLRVREFLMAEIEHYVDPLKKDHPRFSEVENVELQILPKEVQVEGKTDLTTITVGEAVKKGIIDNQTLGYFVARINLFLQKIGINKDRLRFRQHMSNEMAHYASDCWDAEIHTSYGWIECVGCADRSAYDLTVHAVRTGQPLVVREPLPEIKIEEKWAPEINKKKFGPTFRANQKIVESTIFALDQPRLECIKKEFDEQGKSDVQAADGNKYELTPELLTIEKKTFKETKREFTPNVIEPSFGIGRILYALLEHSFYAREQDESRTVLGFPPLVAPIKALVVPISNSKEFEPIIKDISLQLRKNGVASRVDDSSATIGKRYARNDELGTPYGITVDFATVKNKTITLRERDTTEQKIGTIDQVIDTLVKLSKSEIEWSQVDLPAYSGVQDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHR6</accession>
    <name>I4YHR6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956185.1">
        <property type="nucleotide sequence ID" value="XM_006956123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHR6"/>
    <dbReference type="GeneID" id="18473242"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59241"/>
    <dbReference type="HOGENOM" id="CLU_2442547_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHR6"/>
    <dbReference type="OMA" id="PHENAQD"/>
    <dbReference type="OrthoDB" id="3353756at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="9689" checksum="B18E8B6AE475D1DE" modified="2012-09-05" version="1">MLNRGVFRNTARLCNANKDKFVESLKAGSVLEEPTSGISPHEKAQDAREAKDTEQPGPTLADLEKLSAEDLGGGEIGERALGEKGEHKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT2</accession>
    <name>I4YHT2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_35095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956201.1">
        <property type="nucleotide sequence ID" value="XM_006956139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT2"/>
    <dbReference type="FunCoup" id="I4YHT2">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHT2"/>
    <dbReference type="GeneID" id="18471901"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35095"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHT2"/>
    <dbReference type="OMA" id="TKLMPQC"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="16942" checksum="1DAA6B039F5FEF53" modified="2012-09-05" version="1">MMFNLLRNSASTRAAKLLQPVYTPSTLTRLNNFRQLSTESRKLIDQAVNAHPIVLFMKGKPSAPLCGFSRAVVQILDVQGADPEKIRAYDCLEDDELRNGIKEYSDWPTIPQVYVNGEFVGGCDILLSMHQSGELSQLLKDKNLLLEFANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHZ6</accession>
    <name>I4YHZ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956261.1">
        <property type="nucleotide sequence ID" value="XM_006956199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHZ6"/>
    <dbReference type="GeneID" id="18471245"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31090"/>
    <dbReference type="HOGENOM" id="CLU_047639_6_0_1"/>
    <dbReference type="InParanoid" id="I4YHZ6"/>
    <dbReference type="OMA" id="CGNHADN"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697708" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13627" checksum="EFB89BDD5EAF7F0C" modified="2012-09-05" version="1">MFSKTLIVAAIASLVAAAPTPAGAPASKRSNDSYGNMATYYDAETGAAGACGNMLSNNDRFVAVGFNSPLECGQWLGFNVNGKTSYGYVADKCAACADNHYDMSPTLFNEFADQSAGVVNNIWAWELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI28</accession>
    <name>I4YI28_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956290.1">
        <property type="nucleotide sequence ID" value="XM_006956228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI28"/>
    <dbReference type="STRING" id="671144.I4YI28"/>
    <dbReference type="GeneID" id="18471252"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31112"/>
    <dbReference type="eggNOG" id="ENOG502S5E6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078557_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI28"/>
    <dbReference type="OMA" id="PREYCCC"/>
    <dbReference type="OrthoDB" id="2552042at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="32186" checksum="5892C4ACA6380CFD" modified="2012-09-05" version="1">MKLWSSDLCCCAIPMVNFGIYAQLFEFIAVGLAAGIVALASQRVLGAESIPEWPSYILGVLCLLVVIIQPIGFVGVAKEKFRLFRRFHFLNTLLTLCAFMCALAIIIACAAKHSDATTKCQSDYYPPDPDATFTLSQYSGTICNILGWVDIGVMGLLWVLLILVQGYFLWIQRKFSSGQRSDHQKYESVYHSNNGDDYMMSTHRDNAWDARNSYDAYAHDSSSNSYTQGYDNSSSYQQQPYAYNNQTHYQQPYEQDDVYNYNYSPQYKDSPYTKAHLPYGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI78</accession>
    <name>I4YI78_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indole-3-acetaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_31145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956336.1">
        <property type="nucleotide sequence ID" value="XM_006956274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI78"/>
    <dbReference type="STRING" id="671144.I4YI78"/>
    <dbReference type="GeneID" id="18471257"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31145"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="I4YI78"/>
    <dbReference type="OMA" id="GQLIMQY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="498" mass="54017" checksum="CD02A5C593991731" modified="2012-09-05" version="1">MTTFQYDFAANHKNSAFQGKVDFPTGVFINNEFSSGSTGKSIDVINPTTSNTVTKISEGTAEDVDRAVAAAHDAFENSWGLNVHGTERGRLLVRLADLMEKHADELAALESLDNGKPFKFARGFDIPEAAANFRYFGGWADKIQGSTIEVGSELMAHTRKEPIGVCGSIIPWNFPLLMFSWKIAPAIATGNTIVIKPSEITPLTALRMASLIKEAGFPAGVINIVVGYGQTVGNAITDHSGIEKVAFTGSTAVGKLVMKAAANNVKKVTLELGGKSPAIVYADANLENAIQSTAFGIWFNSAQCCCAGSRIYVEESVYDDFVKGFKQHTDQLKSGDPFDDVFFGPVVSETQQSRVNKLIESGKRDAKVIECGEESKLNGYFVRPRIFLDAPAECEIQRTEIFGPAVTITKFSKDTDIVKIANDTEYGLAASVFTENINKAHKTAHAIKAGTVWINQHNTLTKNVPFGGYKQSGVGREMGSEVLNNYLQCKSVFTKFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIB1</accession>
    <name>I4YIB1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956369.1">
        <property type="nucleotide sequence ID" value="XM_006956307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIB1"/>
    <dbReference type="STRING" id="671144.I4YIB1"/>
    <dbReference type="GeneID" id="18471262"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31185"/>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419911_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIB1"/>
    <dbReference type="OMA" id="CESHPIA"/>
    <dbReference type="OrthoDB" id="3350428at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="291"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="354"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="653" mass="72561" checksum="73517894847D533F" modified="2012-09-05" version="1">MKCNVIVQRTQVASLPPPPAQPVPAQPEEQPNQPLQRKGSNKLKKNPKNRESNRFSFLNVLTAAKEPPRSNSYDNLKYYDTNSNQKDPIKQPDGLLPPSEQFLRPPSPQQHPQHPQHRSLPQLHSQPSNGYLGPDVTQQPLTPAPTIPSKAPSTPWYTNLETRLETKNELKTLMEGFLNKLSVTMNSFEQDAHLESLANLTKSQTSLAMHEAVCDGCNNRIQGVRMKCTTCRDYDLCVGCFSVGTHDHETFHRICDPSKPLPSVPKSIDTNTPLLSTNTSVRSSHSKPNAHHSANCDMCKSGIIGTRHKCTICPDYDVCDNCFGRTHEEHPLHEFADLTDPKLIRVPEELQVVHPGVICDGCQNNVVGYRFKCSHPECFDLDLCGNCESSPVAKHDKSHIMLKIRQPILEAQALNQAFAGGFNQDSVPYLEQAQQMKVNRQKSATNLTTISERSVETAKYDVHGTPEFDVPPLHEVINQNDVASYIKANQNNPKSKMVEDFNGGEEREKDTVLKMAGGTQFSHIFEFNSSSKISASNLSRLSPQATFGNSLTISQPNSHLIRVDGFRAPEESGIHSETWSYIDNTIEKTFKLVLFVEDLTNASGDTLPSSALMIPAKAQSSQGASDFREFETDFGTESAAADDYDFELAKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM4</accession>
    <name>I4YIM4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_31291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956479.1">
        <property type="nucleotide sequence ID" value="XM_006956417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM4"/>
    <dbReference type="FunCoup" id="I4YIM4">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="GeneID" id="18471277"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31291"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIM4"/>
    <dbReference type="OMA" id="NSTVLWH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="80"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="358" mass="39891" checksum="39FC3975CE65050D" modified="2012-09-05" version="1">MTTITTLQSASAYQPKTQDYPNVGSANDDPNYPYNHLKPAYPDLKWEPYSETPFEHHNKGHLADKNKKDLFSVTSKIDNIEPAIGTEVTFQEGKNLFTLNEAQLNDLALLAAERGILIFRNQPVDPKKALEFGRYFSPVLHKHPVSPQARAAAEDPDLENLHIIYADKYKKPNTGAFTPTENFHSDITYELQPPTATFLQVITAPPTGGDTVFSSAYAAYDSFSPSLQAYLETLYAVHSGVNQAKGAEAAGHPIRRPPVEHIHPLVRVHPVTGWKALYVQPGFSRALLAKQGDNFVSLPKHENDHVLNLLYRQVADQVDAQVRVRWGSGDVVIFENSVTAHSAIFNSFPNQRHAFRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIS1</accession>
    <name>I4YIS1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955707.1">
        <property type="nucleotide sequence ID" value="XM_006955645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIS1"/>
    <dbReference type="GeneID" id="18471163"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30700"/>
    <dbReference type="HOGENOM" id="CLU_534427_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIS1"/>
    <dbReference type="OMA" id="CSTTCAR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="55827" checksum="93F55C89519A0FA1" modified="2012-09-05" version="1">MYNKTNFGQRNQCLCGRILSSETWDPDSIYCSITCARADALAALTAPEDLTYTRASHYRRVSSKQELQTKAKEASIADVENDNQSYSSQKSASRQSHWKKARQILFGSPGSSDESNPDEKKSKGRVLRRKSKSYSSLNPSKQTKSPPKPLGQPKLKLKQATRQQSESSDEELKPPPLPPKPAKIPLGARHKRVPAIIKIPGRDVEFAHSRNGSTASEAQTTASSATTTTTFQTETTATTAPSSLILDTPVLSSKKASLKDRESLASRITYQQSPETTPIPAKVDTTPIATEAPAISLNTSDNTLMRSPSSSNTIALNRARSKAMRDRAKRLSLAKSSNNLLQVASNQSLTKSLHQSQSCSTFKPATTSTSRQTFESAFDGTNPADYSPSPTWEYDDIYNSNSNLRQTEENENTRGLLPLQPINEVVSPLVDYDLNWFMQHSASYKSIKLAGTGGAPSESPSIPQAMHHNDTVTKRNVSNSHSVTDQNELEDLDDSVKQALLMADDVLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT1</accession>
    <name>I4YIT1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor, CC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955717.1">
        <property type="nucleotide sequence ID" value="XM_006955655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT1"/>
    <dbReference type="FunCoup" id="I4YIT1">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIT1"/>
    <dbReference type="GeneID" id="18473106"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58987"/>
    <dbReference type="eggNOG" id="KOG0147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020551_4_0_1"/>
    <dbReference type="InParanoid" id="I4YIT1"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="225"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="382"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="459" mass="53698" checksum="880B5636500F0439" modified="2012-09-05" version="1">MSAGDRYSPRLSPEDVREDYDYDRERDIRSRDRSRERHDRRRSNYDDRRDRDDRREDRSHRRRRSRSRQRGRYERPRRERSPEIPIEDNVDSLESEQRSVFVSQLSTRTNSSDLRRFFQDRLGERSIVDARIVMDKNSRRSKGIGYVEVKTASLIDKALELTGELLNGIPMIVTQSEADKNRQAKASSSLQTQSVQAEEVRRSTKSRDYDNRSSTINPANDPTLYKVYVGSLSYTLKEYDVRSVFEPFGEIEDVELSVDDQNRSKGYAYVKYKRMEDSRMACEQMNRFELAGRTLKVQLVNYYGDPVRMPEQSIENEGLNLNSVSRHELMKTLMRSHDPNAQFEQELAAREKEKKVQERMKTKGVLLKYMFKASEETEAGWEKELAEDVKTECENKYGKVQEIGVDKESEEGEIVVKFYTIESAEDAINGLNGRWFGGRQVKAVNIADKFLEMKLSVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIU3</accession>
    <name>I4YIU3_WALMC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955729.1">
        <property type="nucleotide sequence ID" value="XM_006955667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIU3"/>
    <dbReference type="GeneID" id="18474673"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61717"/>
    <dbReference type="HOGENOM" id="CLU_1095000_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIU3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="254" mass="29068" checksum="9C89A76AF5C5FAC9" modified="2012-09-05" version="1">MPIDHISHIHSGLHIPEENTDHVEQTRQKRGKGWPERITIAAETQVLEGPFDDPFHKKSRQYRQSIIGDEAFKLPNLQQVAYIYGVDRQDYCDLRTRMRRLVDKNISTGVIKPTEEDGNYQPSGIWDTIRAQMLLELAQDSRNRIICNRLPWLYNQIWYGVLKSQCSKPGRAPKGTGKMPKTPLVSNKQVTSREKPTVFGGLSKNSKKLIRSPSPIAVADYIGLSNPKKRKADSMTVRYTSRNDYDESDDLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ68</accession>
    <name>I4YJ68_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955844.1">
        <property type="nucleotide sequence ID" value="XM_006955782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ68"/>
    <dbReference type="STRING" id="671144.I4YJ68"/>
    <dbReference type="GeneID" id="18471183"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30789"/>
    <dbReference type="eggNOG" id="ENOG502S325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078033_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJ68"/>
    <dbReference type="OMA" id="VEAMQCL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="211" mass="23477" checksum="7F8A774620A9055E" modified="2012-09-05" version="1">MYRFSAITRNLSRSITTRQFNRPLITKPLFGYRWASTSGASSTVDPAESEAFEEMEEGTRLLNEGDLEKAKEHYERSLNIRTTAMGLFNLGVTQFYSKDIPAAIQTWEQSIKLYPSNADAHTNIASAHILSSPSNPEKALHHLQRAKHLSPEDGEIVFNLAVVSEASGHLESALENYQKAKSLGVERAEENVRNVGAKIISEKAKSADEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJI4</accession>
    <name>I4YJI4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_66981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955952.1">
        <property type="nucleotide sequence ID" value="XM_006955890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJI4"/>
    <dbReference type="GeneID" id="18475193"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66981"/>
    <dbReference type="HOGENOM" id="CLU_610032_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJI4"/>
    <dbReference type="OMA" id="LMANMVN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="415" mass="49251" checksum="2C2EE15C63CF0E54" modified="2012-09-05" version="1">MKWLKSKQEGYLDKWIEESTEENLRVLKQQLTEDNISNLMKAIRLKLKLNYRKLEFLILEFVENEVFYSQLNNTKNISFLIDYNELFIKLYLRLKPTNHLIVDAFEHKYQPVLDIVDGYIKHKYTQQQLSFLDTQRDTQLALDLFNNSLIYNKISSKDFAKSYKKCLDFQSKYKPQLEFYHFQSIQSRQNRNEDIKFSVECYKIAGILDDYSDTFTPDELIYQQLNTLLNEIENSFKEYEQLSLHIQQDEELQYVTQQSINDTKFDRSLHLEIPTKRSYDETASSSLSADLSSKQSFDYRRVAYDSQIPDNLLDNKMSNHIPIAFDYANRGESIIPERSPDDEINRIPDYQTEVITEKSLQKRKIDEDLPSYQHQSLTSQDEEVIDYDLSESEEYIDCNPYAGIIETTTPTRTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL8</accession>
    <name>I4YJL8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GCS light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955982.1">
        <property type="nucleotide sequence ID" value="XM_006955920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL8"/>
    <dbReference type="FunCoup" id="I4YJL8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJL8"/>
    <dbReference type="GeneID" id="18473184"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59121"/>
    <dbReference type="eggNOG" id="KOG3023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1039008_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJL8"/>
    <dbReference type="OMA" id="AHEWIPL"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29799" checksum="EA5489E4C8D6A3A7" modified="2012-09-05" version="1">MKKSEVKIVYINCDNVNLNPISISSSKACNNTELLEALNDTLASSDSLNVDDKVKIPSQRRRSPSLSERRSNYEVTAKLFITEKEYNNWSIAKIKDAIDCLNRTTSLSSVDSLILSFNGISDDIYHDNNRLDAAASIWQSLAPEFPTTQLAVADFGPLELENFLNKLTNKARLPQSTQISLSNCCDPPTDLVQQAKKHDIQLTAHPDLHDILSSSELARALKNNDTLLPNRNVPEDGLTVDWVLKYTIIAHGRGVVADKGYIIRASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJZ8</accession>
    <name>I4YJZ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_30976</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956102.1">
        <property type="nucleotide sequence ID" value="XM_006956040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJZ8"/>
    <dbReference type="FunCoup" id="I4YJZ8">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJZ8"/>
    <dbReference type="GeneID" id="18471224"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30976"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJZ8"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="334"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM24290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="726" mass="83490" checksum="8DD48E58B1F5AA7A" modified="2012-09-05" version="1">MNHPEQTNNAPVKQQQPKKEKKDKKAANANKQPVEMTPPPAYLQERLEIWDKLKAAADAELAAKPRQPITITLPDGKQQQGTSYETTPMEIVKSIASSLADRTVISKVNGNLWDLERPFEEDSKVEFLDFNTEEGQQVFWHSSAHVLGEACERHYGSHLAVGPPTDDGFFYEMAIEDRMVYADDYSPLEQIANSAIKDKQPFERLMVSKEKLLELFAYNKYKQHIISSKIPDGTSTTIYRCGPMIDLCRGPHIPHTGKIKAFSVNKHSASYFLGDAKNDSLQRVYGISFPDKKQMVEYKHFVAEAAKRDHRKIGREQELFFFHELSPGSCFFLPNGTRIYNTLLEFLKKEYHARGYQEVITPNMYNTKLWETSGHWQNYAENMFSMDIEKEKFALKPMNCPGHCLLFDMRDRSYKELPFRVADFGVLHRNEASGALTGLTRVRRFQQDDAHIFCRKDQIEDEISDLFDFLEKVYGICGFNFKLKLSTRPEKFLGKIEDWDKAEKNLQNALDKFMPGKWELNPGDGAFYGPKIDITISDALRRNHQCATIQLDFQLPERFKLRYRTGNDEDYIKHEDGSIEKGFDRPVIIHRAILGSLERFIAIVTEHFGGKWPFWLSPRQVIIIPVAHKYDEYANSLQKQLWDNGIIAEVDAGENTLPKKIRNAEIGQHNFIFVVGQEEVDGSSVNVRNRDDAGSKAKTPTVPFSDVLAQMIRLRDEKRLENKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y599</accession>
    <name>I4Y599_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960803.1">
        <property type="nucleotide sequence ID" value="XM_006960741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y599"/>
    <dbReference type="FunCoup" id="I4Y599">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y599"/>
    <dbReference type="GeneID" id="18474639"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61613"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y599"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697719" description="Zinc/iron permease" evidence="8">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31121" checksum="1E70DE574CB50A28" modified="2012-09-05" version="1">MTSRSLNLLLICICITIGSLISALSPQIFKVKQENTMKLATLGAGLLVGSALGIVIPEGIESIYETNQGNSSIVGLLMSAGFVLMLLIDTLIAPHNSHVEEGKVHTSPATHTQQPQIPHRMRSYTPLRPIEDNTHSPAKALSKTAGLTIHSFCDGIALGAASLSNSSNSLSIVVFLAVAIHKAPASLGLSTSLLSLRPQLKTSLYRLCILIFSLSAPISAFLTFFLLRLMNFNNSDSSIPGYALLFSGGTFLFVAAQATSEQLEESTNKKQFIALFLTGIITPILLSLVISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J2</accession>
    <name>I4Y5J2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_41615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960731.1">
        <property type="nucleotide sequence ID" value="XM_006960669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J2"/>
    <dbReference type="STRING" id="671144.I4Y5J2"/>
    <dbReference type="GeneID" id="18472220"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41615"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_1"/>
    <dbReference type="InParanoid" id="I4Y5J2"/>
    <dbReference type="OMA" id="DNPPSWG"/>
    <dbReference type="OrthoDB" id="19448at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698563" description="Peptidase S8/S53 domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="138"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="403" mass="42294" checksum="2D7C2D4223C053A2" modified="2012-09-05" version="1">MKFTGLTLGILASAVYALPTLSDLDDGNFIVTLNDDTDLDDHLNQLGGLLGGSDSVTRKYDNVFKGYAGSFSKTLFQSLSGVLDGHIANIEKDGISYALDLESAAPWGLERISQREKLPEDSDVRALNYDYNYPQPSGAGVDVYVIDTGIRISHEDFEGRASYGFWGGYPDANDDNEHGTHVAGTIGGKTYGVAKSVDLLAVKVLNGTGQGTNSDIIAGINYVVQNSKSTGKPSIASLSLGGDVSPALDKAVQLAIQTGVHFVVAAGNENKNAGDSSPARVEEAITVGASTIYDQRAEFSNYGSVVDIFAPGMNITSTSNKDDTSSLSLSGTSMATPHVSGALASLLSQVGQMSPADASQKLKDIATKGVLGNVEPPCGLFCLAKKSFRRQSGVSNNLLYNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5R7</accession>
    <name>I4Y5R7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_52906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960701.1">
        <property type="nucleotide sequence ID" value="XM_006960639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5R7"/>
    <dbReference type="GeneID" id="18472599"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52906"/>
    <dbReference type="HOGENOM" id="CLU_1511761_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5R7"/>
    <dbReference type="OMA" id="SITFMAS"/>
    <dbReference type="OrthoDB" id="10560643at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697650" evidence="2">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="178" mass="18360" checksum="8CE210AE1994761B" modified="2012-09-05" version="1">MKYSALLIAATAAVVTANPNLFVREAEFNDDAAQECLQNQCQSLNSKINQDCLPIIGGVDSDTDLGNQQAISYYSCICDAMSSASSDCKSCLSSAGEDIDQEMGSVCDEVKTMTTSTPAGTSVTTNTQTTDSNTSPSPSQSANQNSGDSDDDDSSSLQAIPSFAVIASLLAIAGSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5T8</accession>
    <name>I4Y5T8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione synthase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_61512</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960606.1">
        <property type="nucleotide sequence ID" value="XM_006960544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5T8"/>
    <dbReference type="FunCoup" id="I4Y5T8">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5T8"/>
    <dbReference type="GeneID" id="18474575"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61512"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5T8"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="411"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="476"/>
            <end position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="489" mass="55293" checksum="0CAC82C32AD9C39C" modified="2012-09-05" version="1" fragment="single">MEFPPKIEESFEKELIENLRAFCLGNGLVLLPPIKAGETTVSSSEGVQAPVSLFPTPFPRKLYNQALSIQPVFNELYANVARDVEFLDKVMSDVSRFDTFQASLWDQWKSIRDSIVQPNQLLVARSDYLCNTSVSSKGDVKGLSQVEFNTIAASFGALSNQVHQLHDYLSKDVRYSGLHPLLKNDIAENNTLNGLIDGFEAAHKIYKSGYLRSKHSPYILFVVQDNERNVFDQRLLEFELSRRGIRTIRRTLTQLTQQASLSDENALKVNGIEISVVYYRSGYSPDDYTSKKEWDVRKLIELSLAIKCPTLALQLAGCKKVQQVLVDENTLSKYLNPSQVRKIKTYFVEILPFDESDRGKLAHSIVNNVEKCRDFVLKPQREGGGNNIYKEQIKDFVKGVKKEELSQYILMELIKPPANLNNYLVRYTDDRVIPSDVVSELGIYGTVIFNNHTITRNETAGHLLRTKSKESDEGGVAVGISVIDELLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5W4</accession>
    <name>I4Y5W4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_49208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960632.1">
        <property type="nucleotide sequence ID" value="XM_006960570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5W4"/>
    <dbReference type="FunCoup" id="I4Y5W4">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="GeneID" id="18472488"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49208"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5W4"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="261" mass="29892" checksum="CBA4FE54416D0950" modified="2012-09-05" version="1">MVSRSTFSIASGWISLMSWVVVYTPQIYENYRLKSGEGLSLFFVLVMLLGDLTNLIGGVMINLLPPMLLLALYYTSCDVILLYQMYIYRLKPDQETDERVHLLPKRDVSPEELHNQHKRQRFVNFLCTGLVIATGFIAFIININKPYNGPHEQHSDWKGQAIGWTSALLYTTSRIPQIRKNNVTKCEGLSIPLFCFALSGNISYVLQVIFESTDFNYILINSSWLTGTVGTIILDLVVLGQYIYYQHWEASRLTSIDRENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X1</accession>
    <name>I4Y5X1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960639.1">
        <property type="nucleotide sequence ID" value="XM_006960577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X1"/>
    <dbReference type="FunCoup" id="I4Y5X1">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5X1"/>
    <dbReference type="GeneID" id="18474590"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61535"/>
    <dbReference type="eggNOG" id="KOG2477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y5X1"/>
    <dbReference type="OMA" id="FMKCLTR"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="487"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="621"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="83787" checksum="7AF1CA6B75B9C4DE" modified="2012-09-05" version="1">MEIHDDDPPRQEYFDDNLSGTNPSVTNIPTKSDLNLKSNVNSTNNAELPSRIDPTSLPYPSDYTDEVTEGAPPGVAGSLINEDFFSSKMGTAKPKKEDNKPDPNKLQVSSKEINQQFKQGVHVDSYKDETKKTARAGDAGSSWRMMKLKRCYEHAEEEGKHVDELGVDRFGSIDAWRDAQEERRILDERDSKRFNRRESGGSSYRGSPRPNNSPRNMYTSPATSDYGSSRPSSRASFKRPSDTRTPTRSTQPPKQADRINDLKGESKPSTPTVPKVFTPTSSKPSVGRPKSPDSLNKLQAQIMKARLMNKPNLKDLEKEYEIEMEKSKQFIQTGGDVGHGLMNVDLRDKTGLEPVEDRQKTKIEVLPTLDGHGRLYDVGQGRKDESLPTGNKRKKIKNQESIDERTGEITRYNIDDDDQSLAELVRQERFAGGSADQKNYDAEFANAITTDHLYEHGDTDQVDDNAAKYARKKMKSDSQKRQFAIGDFKRTKRVLDSCRFCFGDDGDLPPRCGTIISSGTRVYLALPETEQLVNGHCIIVPIQHCLSTLEADDDVWEEIRNYMKCLMQAFASQNRGVVFYETVMSVKAQLHTVIEAVPVPVDIFEVLPGYFHESILSIESEWTQHKKLIDFSEREFRRALVPNLPYFAILWNYKGNAGFGHVIEGVDKANEEDDSEAKYMDNSQSFPKYFAAEVIGNVLELEPRLWRRPKKLHKQDKEKMVEKFKKFYLEFDWTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6B2</accession>
    <name>I4Y6B2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_48884</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006960367.1"/>
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        <property type="interactions" value="687"/>
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    <dbReference type="STRING" id="671144.I4Y6B2"/>
    <dbReference type="GeneID" id="18472475"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48884"/>
    <dbReference type="eggNOG" id="KOG0862">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_054453_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y6B2"/>
    <dbReference type="OMA" id="FIYWRFF"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:SNAP receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="15">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="206" mass="24285" checksum="EF18412A1B7D6C1C" modified="2012-09-05" version="1">MISTLITRVSDQLPLCASIDDDDLELKEQKQQSKLIIRRLNSQSEPKCTISSGNYNLHYLLVDDICILTITEKSYPQKLIFNYLDELKKEFFNLHANQFINKPYQFQSFELFIQKTTRLFEQPRQFTQLNSELQDVTQIMNKNISDLLWRGDNLDRMSSLSSNLRDESLKYKRAAKKVNFDALIRKYTPIGVIVLLLFIIIYYKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6F0</accession>
    <name>I4Y6F0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_58704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006960403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6F0"/>
    <dbReference type="FunCoup" id="I4Y6F0">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6F0"/>
    <dbReference type="GeneID" id="18473053"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58704"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004007_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6F0"/>
    <dbReference type="OMA" id="ATESNIW"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120283" checksum="586970E8FBD96B40" modified="2012-09-05" version="1">MNRSGYNNKKAQLAQAYQSLTTDLTSPVLRTIGNYTLGRTLGSGSYGIVRLSTHRLVKGARVAVKSVSKTHNQLSALVRELHHYRRLSHPHIAQLLEIVATEKDIHLVTELCDGGELFDYLVDKGRLSDTETRRVFGQLMLALHYLHSNGVVHRDLKLENILLDKDGNVKLGDFGFAREFDDGPGNLMSTWCGTTAYASPEMLRGEKYSGKETDIWSAGIILYALLTGGLPFDDDDEDVMKELVLKGEYYNPSDFLSPDACDLISSILQQKPSDRLTIEQILAHPFFTRFPSQQFPLTTLHEKLEEHNNSYDEKQVADALEEEEFELDLDPNDEPPRRLVPASKSVESLLSIKRRSNGSFKQRSSMNRTFSNEKESGASTPPIQRTPSRTKRRSVSSTMTELPNLTPVASRIPSTTSLRDHFKAGLASASTEELDMYPQEPNYLELCKAVLAQPFEEEWERVLLQSLSEIGFDTGQIKHSVINHACDAAGGLWWLIRKQNIERREQLSRIEEEGALERRDSEAEYLMMKDTRKQKENVRMNEQRADFSKKSLLDLSESSHTGQSSSNTAPTVQVEASTSSLQLPNTSAPSSPSKTKSRSSSISMLQRATTALSGGVLPRKKSEDHSLNDETVTPPPNHQSLTADPRTSSSSLNQSSPVKTLNESKNESKDSFVSSPNKSASKDNNKKNLFNTFRTWFTDDKREKRKSKTTKQHPKGASSLSDASYVQVRRSASHKSNTKNRKPRPQSYRRRESTSSTHSLKSPQITAMTSASKSRRSSSIHSRRSSVSVQIDLSSSPSATPMNRRSSGNNISSGVRGKANHSKSPSMSSVGSNRSTGGRPNPAYGRRHRRGSSSSLPRVRHIRAPSSPLPLTSKKHSRSISATSSMEEDKQVLGLGLKDSDTIVSQKTYFLASKRTAAFAPPPPINVKSPVMKSFGNLKASKFDYSKASPTKISTNFNPTESTLEDALEWVDEDDFAGGIGQGEASAFIGEFEAGIQEDDDFLTEHSDNDNEIEGVKKLRKKSKGKRKNDDKSDNNTETLSEFKFPSSTPPTSAQGPNQSNTNHQKWRPSVTTAAVIEEDEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6N4</accession>
    <name>I4Y6N4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_22100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960289.1">
        <property type="nucleotide sequence ID" value="XM_006960227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6N4"/>
    <dbReference type="FunCoup" id="I4Y6N4">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6N4"/>
    <dbReference type="GeneID" id="18470910"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22100"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y6N4"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="284"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="359"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="426"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="704" mass="81560" checksum="C3563C762868051A" modified="2012-09-05" version="1">MPTKEELKPHITPLIYTFISALTRLIWINYEPSVVWDEAHFGKFGSYYLKRTFYFDVHPPLGKMLVGLAGALSGYNGNFEFKSGEPYPNDLHYGIFRGYLAIFGVLIVPLAWYTSEELRLSKRSCHLVTLMVLFDTALATISRFILLDSMLLFFTFTTVFFLTKFHNERHDQFGFDWWMWLVFTGLSIGCVCSVKWVGLFVTAVVGIYTITDLWDKFGDLKLPKQTYAYHWVARIGCLILIPIIVYVASFKAHFAILNRSGSGDSQMSSLFQANLKGNKFYKSPLEVAYGSKITLKQMGYAGGLLHSHVQNFPLGSLEGQVTCYHYQDDNNQFNVLPTLQEEKANELKVLNEGDNADNVTFLHDGDVIRLEHVPYSRYIHAHDIPAPLSKLDYEVAAFGQSTEDDTNDNWIVEVVDDVYRGRLSKEDKIHSLTTRLRFKNKNLGCYLRAANKNLPEWGFKQIEVTCTKENDPRDDHTYWNVESHWNDKLPAGKKSLYKTSFLKDFWHLNIAMMMSNNALIPNPDKQDILASKPTDWPFLRLGLRMNGWGDHNTKYYLIGNPVVWWTSSLALFVFVAISLYHTIRERRRVRDVTKNEIDYFTYVGMIAFGGWVFHYIPFLIMGRVTYLHHYLPALYFAILVMGLVLDHLIFKRQIPERFKWFVFGLLAVNTIVTFYHFNGVVFGMVGPISKHKHLKWRNSWNIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6R4</accession>
    <name>I4Y6R4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_33913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960318.1">
        <property type="nucleotide sequence ID" value="XM_006960256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6R4"/>
    <dbReference type="STRING" id="671144.I4Y6R4"/>
    <dbReference type="GeneID" id="18471773"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33913"/>
    <dbReference type="eggNOG" id="ENOG502S1PI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622876_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6R4"/>
    <dbReference type="OMA" id="ARTNFIN"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="440" mass="48744" checksum="942C32B6DE54329E" modified="2012-09-05" version="1">MLGYEPAPLMPTAAVPGILIVSASGRDVACALPNNLSDAMASAKERWSIPNDLVFRLGVKKKDAPGYLANTAQGDLIILGDDAVYQLVKMGKSVLRTEIQVYASKEVKPKEEKPPPPPPEPVPIKITVENSKGKMFRLDTKALPDINMDWSQSQGGQSMVGSFLGQLTIKPQTDPEGRITFSGKEIPNDLNFSTFTNNKNEMKTVQFRKSSSKPFIQIFSPIEQFLTLELSLSGSWQCKSTWPASEIKKEKEKQLVGFFLRVGPGTTIEDVVSGCKTAGLSWEAVPNAGCPRLSPDDKTPFDPANPDLVDYNGVLLSAKDCPARLDKILAEQFKIDPLVRTNFMADITPHLFRYPNIAFRFLPQDFYEPAATLAIRPTPEVTGRIFLLWQGVTDADKWKASKKRDKMPINWAEIVGFNTESLTNDSLFRCIEVGWMEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6S9</accession>
    <name>I4Y6S9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_66173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960332.1">
        <property type="nucleotide sequence ID" value="XM_006960270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6S9"/>
    <dbReference type="FunCoup" id="I4Y6S9">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6S9"/>
    <dbReference type="GeneID" id="18475090"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66173"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="InParanoid" id="I4Y6S9"/>
    <dbReference type="OMA" id="GPDEVMW"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="416" mass="44499" checksum="B9BA9701F7D6F146" modified="2012-09-05" version="1">MSDPQQENIEEQDGQDLYLNKDEMLEEDLEDTGEPMEDDDDEGELEPELDEEQQANIDMINAKDDSIQGFFGHKEPVYAIAIHPNNPEIIVSAGGDDKAHVWNITDGEHAIASLEGHTDSVTSVAFSKDGQFVATGGMDGFVKIWDTSDWSLKVDLQLGDECTWIDWHPRGTVLLTGCADTTIWMWKLPKGDNMNVFSGHTEMVTCGRFTPDGKAIVSSSSDGSLIMWSPTEGTAVTKITANDARFNLDGGITAMAVNPAGTIVVAGGAAGGVRAVNLSNGQVVGSFECHKEGESIEAVAFLPEGAAGQGPAGVVVTAGTDGVLNVIDLTTMRVRNTMNIEEPITVLEFQHQSPFFAVGCVDHKVRMFDARTGSQVKEFEGHSEPVLSVAVSKDGSRIITGSDDGTALVFDGSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6V8</accession>
    <name>I4Y6V8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960208.1">
        <property type="nucleotide sequence ID" value="XM_006960146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6V8"/>
    <dbReference type="GeneID" id="18474462"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61322"/>
    <dbReference type="HOGENOM" id="CLU_1636733_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6V8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="162" mass="18725" checksum="4824636C9FDED932" modified="2012-09-05" version="1">MSSELFKEKGSFGFSFVQDGDVDLVDDSVPIQQEVIPPAIQVDKNQFIPNNRQFHLNIGSSQQQHRDTGPRRLEAISSVEGAYYMLPYLNLSKDDEPTRLREPRGWLEMPVEAPFTANEEPDQAEQRWENLKADLTFNYKRRAREAQKSKRRRNNLTADDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Z8</accession>
    <name>I4Y6Z8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960248.1">
        <property type="nucleotide sequence ID" value="XM_006960186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Z8"/>
    <dbReference type="STRING" id="671144.I4Y6Z8"/>
    <dbReference type="GeneID" id="18471764"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33871"/>
    <dbReference type="eggNOG" id="KOG4682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006358_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Z8"/>
    <dbReference type="OMA" id="CWLEMQD"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="873" mass="96496" checksum="E9114DEF2DA463D5" modified="2012-09-05" version="1">MAKSKNKGIRFIPFTSKSSMSSTSSSLHVPKVSSTPPHVPSTDFTFQHKQPQRQPSQQQKQPTLPPDHQVLATLHSHIYFQGFLLGVGSDVKVKVPKWGRLYRLHKIILTQSTFFNSLFQGAFLETNNNEITLTFDDPNITRSSFEYCLGYLYGKSSNLVLDSKFKPTPQYPLTPSYPTFEQPQSNSSNTQLATPEFCVSLIATAIYLGCPSIANKALNFILASISPINVSFFLKFALGEGLGAHRHWYPGEQEAAVGMEEIGLVMEKCLDTHIETSESEATPSGVATPISASHENNLDKLSTIDIASKTEDYSVDSDTEDYIPSFHYGAASDKIGEACVCWLSRWALEIIEIEDILVNDDGEITHPSGCIPFATWSLEGIPAKWIRAVISSDSLFVPGGEWQRYKLASRIVELRRRQNKGALSYSDECEFDRMFADGIYYTHMTFEQLSIIQREMSPTTGRPYVPIRILQQALWSHSELQNRIEVSSKTSAENSDLSLTFNSWEIREKLRSKDGKAWSEKRFFPVGKDSTERLGDATSMYHSDDDLNKFVSPPTGHRQNEDDASGLAGSTHDPLVGVSSSSHRRPHTEAQLFGVQKSHKTGLEISKLIEADHSPTTDVGDTISIASSSPTAKRAKEDRWTLIEPLRFSVEYWIKSELEPREKKFSHAVFYAGSFINTYIQINEQKHKHGNQLGIYVHRQSMDEPLPYASSPPNAANSSGNVVSPLLNNNNTSSAVPLSPASTMDTILRVNSAGSDDSQGSNSNNQPAPQSPPSDTAKVGPGKHSGSQNVPFAPYKDTRKTMRAFFAVQCSSGNGTAFTKFSSAPDNFTTSQSWGWKSSVQRSSEYLANHNVGPSEQLGVLNSLRAVVSVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B9</accession>
    <name>I4Y7B9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_70219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960003.1">
        <property type="nucleotide sequence ID" value="XM_006959941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B9"/>
    <dbReference type="STRING" id="671144.I4Y7B9"/>
    <dbReference type="GeneID" id="18475700"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70219"/>
    <dbReference type="HOGENOM" id="CLU_071900_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7B9"/>
    <dbReference type="OMA" id="PLAYQPY"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="35303" checksum="16BA5492463D3307" modified="2012-09-05" version="1">MSEVIKTEDNSNDQHVIDDVYDGVEEDKNNEQTRAPVAEEATPAAPPKEEKKEDEDKATMEKVAAMSVMFPSIDKEIILSVLKSSSTQERAVETLLQMSDPSTQSQTQKPSRQFDDDEALARRLQEMDFERNGRASSTPYDDLGYEPRKPRRQQKPPPEQFENLEPGFNFSDITNAFSELATTSKKHLNDFWSSLTEGYNTVQNTAEEHLGEHRPAKRSTQIDDPYAHHYDPQIHRRAQKHNRQSIIQMKDNSTDKNTTHQTQPSDLSGLGFLPRREIDLSQHKRNTNTSENEEDDDYTHNPFNERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7G8</accession>
    <name>I4Y7G8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960051.1">
        <property type="nucleotide sequence ID" value="XM_006959989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7G8"/>
    <dbReference type="STRING" id="671144.I4Y7G8"/>
    <dbReference type="GeneID" id="18474417"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61249"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_1_1"/>
    <dbReference type="InParanoid" id="I4Y7G8"/>
    <dbReference type="OMA" id="WGERAYY"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="36151" checksum="FC175CE462FA5537" modified="2012-09-05" version="1">MTKVFITGATGYIGGSILSRYLEHYPDFTFRALVRSAEKADKLNEIKNVEAVIGDNNSDAVIQEEAKNADIVVHTSMSADDLPSTKSIVNGILKGKGRNAIYIHVSGTGALVDDARGAHDQIASYDDADSTHINTLPASNIHRDVDTYLLEQSDKIQLHLVYPSTIWGQNYGHQLAKRGISNPISMQIPDLTKAAIALKQAKTVGAGKNIWPNVNIEELVDLFVLVLDNALAGKITSDKNGSYFFGATDHYYFKDAVKIIAESLSKHGLSKNTVEPFTDEEAKKYVGGFYLGSNGRATASRGKSIGWSPTKGTKEFFQDIPSLVDDLVKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7M0</accession>
    <name>I4Y7M0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_30034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960100.1">
        <property type="nucleotide sequence ID" value="XM_006960038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7M0"/>
    <dbReference type="STRING" id="671144.I4Y7M0"/>
    <dbReference type="GeneID" id="18471126"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30034"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_10_6_1"/>
    <dbReference type="InParanoid" id="I4Y7M0"/>
    <dbReference type="OMA" id="ENIMHEY"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="235"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="329"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="333"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="52018" checksum="1A2287BD7F1B5477" modified="2012-09-05" version="1">MASRLQINNSRRLNATRTKTADENNLSQQLRSKQAGMPLRTAKSSNSLSVNSNKRSAFGDLSNQEKRPTNSKTTNTKRASSFSEVSSIPQTKLRIVQPTSKLQVYNEDDQMSDDEVDDGPPDIDLTDEEDEVVSPEEAEEVLGDDDEQDIMEEDQIEDEDWVTKHVEVPSLIEEVNRVQSNYKEDFDFWDTTMVAEYAPEIFSYMCEQEIETMANPNYMEFQSEIEWSMRSTLIDWLLQVHLRYHMLPETLWIAINIIDRFLSVRVVSLVKLQLVGVTAMFIAAKYEEILAPSVDEFVYMTENGYTREEILKGERIILQTLNFSISSYSSPYTWVRRISKADNYDIQTRTLSKFIMEVALLDNRFIRARPSLIAAVGMYASRVMLGGDWNEDFVYYSGFSESQLETPMDFIIEKLIQPDFDQQFCYKKYSNRKFLKASIFARDWALRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R1</accession>
    <name>I4Y7R1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959933.1">
        <property type="nucleotide sequence ID" value="XM_006959871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R1"/>
    <dbReference type="GeneID" id="18471121"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29941"/>
    <dbReference type="HOGENOM" id="CLU_1653516_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7R1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697601" evidence="2">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="18106" checksum="7768268BA55099FE" modified="2012-09-05" version="1">MQIKFLGIAALVAAVSAGPVVRDNDVESYTNIRPNQLWKRDVGEESYTSPPPNQTYKRVNEEGLVNPPPNQTYKRVTEEGLVNPPPNQTYKRNDEEGLVNPPPNQTYKRVNEEGLVNPPPNQTYKRGGNSEESYTNLRPNQTWKRVDEEGLVNQGPNQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W5</accession>
    <name>I4Y7W5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959986.1">
        <property type="nucleotide sequence ID" value="XM_006959924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W5"/>
    <dbReference type="GeneID" id="18474400"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61220"/>
    <dbReference type="HOGENOM" id="CLU_2428745_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7W5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="91" mass="10431" checksum="3D3F8DB0EC10027A" modified="2012-09-05" version="1">MLRSRPGIHHQRCSKHPREAHHVSARTLKDRLRRWRAQNDRQRFRMCTCVFAMYSSLTSLVVQSVPAAPGTEQRCKTASSMPCATCPRTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y815</accession>
    <name>I4Y815_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_21269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959828.1">
        <property type="nucleotide sequence ID" value="XM_006959766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y815"/>
    <dbReference type="STRING" id="671144.I4Y815"/>
    <dbReference type="GeneID" id="18470880"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21269"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_43_1"/>
    <dbReference type="InParanoid" id="I4Y815"/>
    <dbReference type="OMA" id="HFILLRC"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="397" mass="45519" checksum="008E1CA236D15E47" modified="2012-09-05" version="1">MGGICCKPQVIDFDGPVDLWHFSLLRAVGKGAFGKVRVVQHKQTKKLYALKYINKDKCVKMRAVDNIIQERRLLEEIDCPYVVNLRYAFQDDENLFMVIDLMLGGDLRFHLERNGAFDEQTVKIYVAEIALALDYLHKRRIVHRDVKPDNILLDEQGHAHLTDFNIACFLGKRALTGVAGSMAYMAPEVLEKRGYFTTVDWWSLGIVAFELLFNKRPFRARTNSSLTNAITKQELIFPDNAYDLVSKDGISAINGLLTRDPDLRLGCSEYGGFEELMKHPWFSNLDWDALSKKQLPPTFVPDSKKANFDATHELEELLLEDNPLKAKKRDPKRDISTLEPVFVKMEEKFGVYDYTRMRRKSYFRANGDTNMTISTQQQPLVPLEEQPNQSASVTNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y880</accession>
    <name>I4Y880_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959660.1">
        <property type="nucleotide sequence ID" value="XM_006959598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y880"/>
    <dbReference type="GeneID" id="18475029"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65530"/>
    <dbReference type="HOGENOM" id="CLU_1961292_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y880"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="14625" checksum="7DDC07D59281F3B2" modified="2012-09-05" version="1">MLASDSSPLAEQFNEALLEAAEQIGRHVTNNLNEYLYKKHGLCDQIKQTLRDIKEEIVTLDDSHTASKYTDKASRVSPVVSSNKDITNIPYQGDTIKPIISETEKISEEMKRFIEERITSAFNYQIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D7</accession>
    <name>I4Y8D7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959717.1">
        <property type="nucleotide sequence ID" value="XM_006959655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D7"/>
    <dbReference type="FunCoup" id="I4Y8D7">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="GeneID" id="18474317"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61065"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8D7"/>
    <dbReference type="OMA" id="PRIHLGV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="282" mass="32098" checksum="A33B03342E7EF10C" modified="2012-09-05" version="1">MAFTLTSRVGLQNGKDIPVLGFGTYESSTEEAYTSVKQALEAGYRHIDTAEWYENEEACGRAINDFMKESNTPRNEIFYTTKLMANNGLEHARKAIRESVRLSGLGYLDLYLIHGPYPSKEARLASWKAIEEAIDEGLIKSAGVSNYGVRHLEELYETSPRYPVTVNQLDLHPFMQRSEDVEYNKRRGIVLEAWGPLARAMRFNNPVLKRISESHSKSPAQVLLRWSIQKGYVPLPKSVKKERLAANKEIFDFELSNDDMNNLDQLDEYLVTDWDPIGDASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I5</accession>
    <name>I4Y8I5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959765.1">
        <property type="nucleotide sequence ID" value="XM_006959703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I5"/>
    <dbReference type="STRING" id="671144.I4Y8I5"/>
    <dbReference type="GeneID" id="18474326"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61086"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025002_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8I5"/>
    <dbReference type="OMA" id="GPMSEVI"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="432" mass="48675" checksum="F70D85D3FF07BA5F" modified="2012-09-05" version="1">MTIDDDDVNGFKNTLIGKRILTKKEKKMKKKGQLPPPGPSWDDDYDPYKPTDYSEYKQFAAYLKEERIARKAEELSRRQYSSSEYSDSDDDKADESDRGKNKMFAPPSVYDNDEPTVINKEETGDEVFQRRLAMSSASAQKARMDNSGNDTPVVIEVKEEEYKEVSQPPKLQLQEQQQPPPPAPTTIENLPNTTKESTPSQSQPTMEERLKASQAAAASIAEKFSKLVPKKPTPTQTPPQNTELPSVKNEVDDFLSTIEDSTVSKEEQDRGEHKAKFAERFMAMHGWKQGEGLGANKSGIKEALTLERSESGAGEIISKEEARLDREARDLYGEPSKTIILRNMVSIDEVDNELSQEIAEECNKNGIVERVVIHTPREYNDPIDAVKILVKFSGLVGAYKNVRELNGRFFGGSQVKARYYPDNAFDRGNYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L7</accession>
    <name>I4Y8L7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_33373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959566.1">
        <property type="nucleotide sequence ID" value="XM_006959504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L7"/>
    <dbReference type="FunCoup" id="I4Y8L7">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L7"/>
    <dbReference type="GeneID" id="18471664"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33373"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004312_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L7"/>
    <dbReference type="OMA" id="NSNMKER"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="125"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="552" mass="63828" checksum="BDD0A8EECB518E53" modified="2012-09-05" version="1">MQIDTQWKDAEMRSFEPPPSPPVSLNEQISKKSSSDYLHPSSAAKSSNIKQKSLNSLVSTQPQSSQPAISATPNVDDDIAFRQAQLKQERAEKARAVQQAHEQQESQAIRKRQSSDQPLVGNLIGEDHANYVLMYNMLTGIRIGVSRCQAKLRRPLTDADFKAKHKFSFDIVGNELTPSAKYDFKFKDYAPWVFRSLRDDYFHLDPADYLLSLTAKYILTELGSPGKSGSFFYFSRDFKYIIKTVSHTEHKFLLSILKDYYEHVKSNPHTLLSRFYGLHRVKLPRGRKIHFVIMNNLFPPHRDIHETYDLKGSAIGREYPEEMIKEKPGAVLKDLNWVHRHRRLELGPEKRALFLTQLNRDTQLLQRLGIMDYSLLLGIHDMTRGNSEGRRKDTLKVYQPQLEGSVPEDQPLNTGSTSIQRRVSSAIHRGESRNVRMSIRRTEPKNLDKDPSRALNNADIAERRHFWFYQDEGGYRATDDQNDDLDIIYYLGVIDICTPYNLVKRIEHRWKSLTHDTQMISAIPAQQYGERFIQFMKSTVRGADISQRPKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8P4</accession>
    <name>I4Y8P4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_47705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959593.1">
        <property type="nucleotide sequence ID" value="XM_006959531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8P4"/>
    <dbReference type="STRING" id="671144.I4Y8P4"/>
    <dbReference type="GeneID" id="18472425"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47705"/>
    <dbReference type="eggNOG" id="KOG4120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042829_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y8P4"/>
    <dbReference type="OMA" id="RSYTEFE"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="4">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="27408" checksum="85619A05DE58CD68" modified="2012-09-05" version="1">MEDTSTVKKRKHGYEPPESFAHLEGVPDYILEGSDLMIVGINPGRTSSIRGHHFAHPSNSFYACLYESGLTSRKLRPDEDYTLPEFGYSITNLNSRPTVMQSQLSKAESRASVPELVKKILRCKPKLVAFIGKAIWEDCEWVFKDAIKGFDSKAIKRTKTSKEKTGDCDESAGFLLQNYKIVHDDGSQSLFFTLPSTSGLVASYQKPAKVRAFTRCRETLEKLKCSYLDTTKMFTIDVEKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8S8</accession>
    <name>I4Y8S8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959627.1">
        <property type="nucleotide sequence ID" value="XM_006959565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8S8"/>
    <dbReference type="FunCoup" id="I4Y8S8">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="GeneID" id="18474290"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61024"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="InParanoid" id="I4Y8S8"/>
    <dbReference type="OMA" id="FIMLARE"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="482" mass="53387" checksum="63877ADD5A5031D0" modified="2012-09-05" version="1">MSDKDITTFDKDTEKNSELFLVDSLEGDSPKLWPAWKRWSLTVFVGIIAIASAMASAGTTGVAEDIMAEFDFTDEIEATLCLSVYMLGYVLGPIWGPASEAFGRKYTLIFCLWVLTLFNIADAVSSTPEALYVCRFFAGFFGGCMIIVVGPCIGDMFTAKDKQVALAIYACCPYLGPSIAPIVSGFIHDSGTSWRWMFGVLAIFSGSCAILALFILPETYEPVLLVWKAKKLRKETQDKRYVAPKELQTKGMSGVMNDIFTKPFVMLAYEPMLAALSFYSAFVYGVQYLLFEAFQFVYSAEKGGHDMSNGVRGLCFIPLSLGSVIAAMVTALFFNRRYIKRMNETGEKPPPEIRLEGACLGGIFGIIFFFWFGWTSYPWISPWSPIIASTLWGAAQCMVYLAQVSYINDCYTISAASALSGLVMCRSLFAFAFPLFANKMYEGIGPRWACTILGIVQIVLAIVPWVLIYKGPAFRARSKFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U8</accession>
    <name>I4Y8U8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959646.1">
        <property type="nucleotide sequence ID" value="XM_006959584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U8"/>
    <dbReference type="GeneID" id="18475664"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69940"/>
    <dbReference type="eggNOG" id="ENOG502QPIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014633_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y8U8"/>
    <dbReference type="OMA" id="KHGRKMN"/>
    <dbReference type="OrthoDB" id="76038at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="575" mass="66146" checksum="3DD3A8ECA7ECEB88" modified="2012-09-05" version="1">MVNQKIEAVKTEVNDVIVIGAGPHSLAICSRMLEKNPSAIYTDLEHARLSWLNKYKRLNYKPKGFKRKLVNNPNDMDGLSVRVFDKHVNQGWMPHWYCMFENLEIRSLRSPMFFHSSPRDVDALLAYAYSNGRQNELQDIPGVVGKELSKHAKKRLVKTGKRPSYEDPVNERNRQDFRTPGSKCFFDFCREDIQQYYGIDSLVQQADIVNLEYDYFDENIPDKIFRLTGKDGRQTLSKTVVMAIGNNTIVNLPSYLADKVKPTTEHGVEGDGWCHTSSFARPGYDFPNKHLRAKSDARLLVVGGGLTSAQIIDKAYRNGITNITLICRSHLKMKPFDFDTEWVDKFQNLSKMIFWREDCRQMRHSMISKARNGGSVNAPYYKLLKDLENKGVLKILTCTEITEAKYNDSRWDVKATTKTAMRSRRTSKDSSFGDMKMENHQLMFDYIVSATGSKIDINEVDFLKKFMKENPIETTNGLPHITEDLQWTSDIPLFVMGGFASLELGPSSFNLGGSRDGAERIANRMNEILVKHNKEYEIRQSKHSEYNDDDLRYKWMERLALNNGGYFDLLTESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9D1</accession>
    <name>I4Y9D1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959365.1">
        <property type="nucleotide sequence ID" value="XM_006959303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9D1"/>
    <dbReference type="STRING" id="671144.I4Y9D1"/>
    <dbReference type="GeneID" id="18475629"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69725"/>
    <dbReference type="eggNOG" id="ENOG502S8PK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903727_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9D1"/>
    <dbReference type="OMA" id="AHENRPM"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="308" mass="33840" checksum="70A0EAA7C4C8DDCC" modified="2012-09-05" version="1">MLVGDYGSSDEEDERVEQTNSGTKATLFSALPEPRTKEKKKAPVQIRSDSVKSSKQEEDDDVAALVGESSKKSVSETPKTGGNGLSGLLGILPQPKQQQQQQQQHQSKHLDKNTDVEESTSSSSRSNKRSAPIDIFSLGASSSKKLHKEEKQPQSTFSTSVAPELPEYTPPDPSPYDPYPGYYQMPTGEWQAYDSAFYKSKVRQWQIESGVDVEAAEEEERKRKLGLSGKDVVDVSAKDIQKQVRPTQIGPEKPEQPIEVKGPQGRGARARGQLSSLISEAVNNRTELEEKIAQGKANRGTSSKVYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N2</accession>
    <name>I4Y9N2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_20182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959181.1">
        <property type="nucleotide sequence ID" value="XM_006959119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N2"/>
    <dbReference type="FunCoup" id="I4Y9N2">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9N2"/>
    <dbReference type="GeneID" id="18470827"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20182"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y9N2"/>
    <dbReference type="OMA" id="WKRIMKK"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="15138" checksum="A931999C42A5BBB6" modified="2012-09-05" version="1">MKRKGHNPNPRDMNTIVPIHNAVNERAWMEIKKWEDGKSDCEIYLHSFKGRPQDRSPKAWIKTALGYTPPFDRHDWIIDRCGQRVRYVIDFYSGSNKMGLNTPSFYLDVRPALDDFDSLTQRLWKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9X3</accession>
    <name>I4Y9X3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_47261</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959291.1">
        <property type="nucleotide sequence ID" value="XM_006959229.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9X3"/>
    <dbReference type="GeneID" id="18472413"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47261"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9X3"/>
    <dbReference type="OMA" id="PTMRGSE"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1196"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1591"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1620"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1646"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="18">
        <location>
            <begin position="12"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="19">
        <location>
            <begin position="1844"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1820"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1822"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1903" mass="214789" checksum="A371A383FFD3164B" modified="2012-09-05" version="1">MAEITNLNSLIKLNDNRDTLLYPNTDDIISLLQSRFRLDLPFIKLGSSSFITINPLKHLQSYNAESQREYKDLTYDPSTSILQPHPYDLSSRILLSLKRKSVSQAVIYNGLTGSGKSFNRSLITNQLLFLTNTSLESSQLIEKIQALDVIINSFGNAKTSLSSNASRHSILHELQFTKSGKLIGSKSLPFNLDKSRLSLLGPDERSFHVFYQFLAGAPPNLQQLYELQDPSSYAMLASSGCFKLPFGPFSDDHAGYNSLYDAFITLGFKQKHIDAIWSLIVAILTLSNIEFSDAETRDTSAAVSTTHELEIASHLLGIEPDELEVLLVNRSVYIKKDISTHLLDAKGASLQRDHLIQDLYAILFAYVIESGNHKLVSERSALQVLQFDIPGFSNRSPTNSVMSRQSYPLINSTTSGYHDFNINYTAEILNSYLLRRVFDDSSAYNGMQTNDGLQLPNKGIANSETLHLLRGSSTYPSTHPPPGKPLGVLGLLNQSGKQIKSGTLLEKNADDAFINSIGGAFHTHKAFVFTPPTYGNSASSQFTINHYAGHVSYDAHDFIQRDQDRLDPLTVSTLRSSNSSFIGKLFSGPSLFTKMHPVDEETIADSQISSMPLRDVSPITNPIDAGLSQATSKQNLSSYEIHPISSQIDVSLADMLNAVDKCQLWSVISLRPNDSLSPNAIDKRRLRYQLDALSIADTIARKRAEYVSHYTFEDFCMRYISGEPVDDSDVAKQAAQTYLTEHELGNGLDYELGNEYVWLSYAAWKILEDDIRDINEEEHSEGEDSYGELPKEMTVDRPDMTRASTNFVPMTTTPYNESDDGYGFPQTVTKNYEPVDDETPSYTKKDFNDDDESGLEYGWTDKDAISEKSRSQSFIAQRQQDVQKAPRSTSRRLWVKLVWAFTWFIPSFLLSTIGRMKRPDVRFAWREKLTLCMLIALFCGIVLFYIIGFGKILCPRYNKAWSEGQLGEYTADDNFWVGIRGSVYDISDFWRSQHSDIDSRPVSSDLMHQLAGLDLTDYFPPPLEWACEGLTDGDVPTFNAQKQLEVPTADHTSGRQYQGAESTALESSNWYADTFLPKMKPMLKGSMVIQKSDVEKDGFDNNKQKAIYDNGVYDLTTYLSTLDYYQSTNDKVEYMDKSVTDLFKKNAGQDITKDLNNVLNGMDSTRANQHKQCLKRAHFLGEVDFRDTPRCQVQNYILLSFTVFLCCILLVKFLSALQLGSKRKPELQDKFIICQVPAYTEGEESLKKTIDSLAGLEYDDKRKLILVICDGNIIGGGNDRTTPRIVLDIFGVDPQIDPEPLLFKSLGEGGKQMNYGKVYSGLYEFEGHVVPFMVVAKVGKPTERSKPGNRGKRDSQILVMRFLNRVHFNSPMYPLELEMMHQMKNIIGIDPSFYEYLFMVDADTSVTPEAANRLVANCVDDSAIIGICGETRLDNEEDSWWTMIQVYEYFISHHLAKAFESLFGTVTCLPGCFSMYRLRTEDKGKPLIISTRVIEDYSENNVDTLHKKNLLSLGEDRYLTTIMLKYFASFKLKFTADAIAHTAAPETWSILMSQRRRWINSTVHNFTELINLPDICGFLCFSMRFIVIIDLISTILLPAVLIYLIYLITIVAIGQGPFPIITIIMLAATYGFQIVIFLLKREWQYVGWMLIYLISYPLWSFYLPLYSFWHFDDFGWGSTRVVIGEKGHTKIVATDEEPFDESQLPLKTFDDYEQELYTKTNGSNPFSDARGMSSTISDFQFPPPQANMNMPRPYSTYTLATNNLMPNNPYAPTPSPYNPPGLAPSRMSRMSFNPYASMYGMSEQQLLPQSHSQSQFGFGMPTPQSDVQTASRPASAAYSTSLSDPTDDNILMSLRQYLATTPLMQVTKRTAREHIAERYPEVDIENKKDFINSSIDAILEGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA81</accession>
    <name>I4YA81_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959133.1">
        <property type="nucleotide sequence ID" value="XM_006959071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA81"/>
    <dbReference type="GeneID" id="18472965"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57924"/>
    <dbReference type="HOGENOM" id="CLU_477517_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA81"/>
    <dbReference type="OMA" id="ENSRTFC"/>
    <dbReference type="OrthoDB" id="10634428at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="609" mass="67280" checksum="48A3A20E29A02D40" modified="2012-09-05" version="1">MTSIHTFLSISTEEENDEYVEFTDYFGSHAFLSHVWTRELSDKDTNKQLSHLPPFRVTDDDVIEFQTQKRVNGSTFVPTGKYCSWNKLSELNPGVVKPQPRPEQFKVRSDDHTSTTSQFNKSSSPRKDNKESDIHVSPTKSSGASRWATSTKTQTVGQMPKDIPNGAARETPKQPSLISRLNNDQLGNTPEKSTTRRRSNGQTNIQKAAPPHLTQSTATMDNHNRVPELQKRAQLPHPQIPSQLNPDASQFNFGSVQNRRSSLGSRRNRQNEQQGDKNSDILKIKKESIPKTTPDTNTSLWAPKPASTSLHAPNPSVEAAETKVSTSRPPKLPPTGPRKSNTDRKSSLNKTGKPKHNDIGMGNAHGSANTSTTNGPDNGQVNAHANSKTNGHSRGHTRQSSVNELLLRLRAATLATDQDGASGSVTEQSQSQLEPIKVVPPRKPSQSRQPSTVPPNKTSQLSPPSKPSQLSEPRKQAHIPSSKPFFPPQKPRRQSYQKEAAVLSTTASMHAPRDQLNTRKPSYDGKPTPFRFAEPPKAPRSMRKGNVLQPQAKPFTPAQRPIQTAESSRPVKHQHKDPNLRHKTSLTSNISWADADDGMDLPDISALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA83</accession>
    <name>I4YA83_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959135.1">
        <property type="nucleotide sequence ID" value="XM_006959073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA83"/>
    <dbReference type="GeneID" id="18474984"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65034"/>
    <dbReference type="HOGENOM" id="CLU_858438_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA83"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="38053" checksum="68AC8E7EB4009E21" modified="2012-09-05" version="1">MNLGDNESRVAQFHDHIRAAIADAVANERAIRAEVVANERAANETRIRVLQEELERLRSNFEVTQQAKEDAYRAFWQETIRKLEETRKETPLNDKVGDGKLKIKEPPTFAGGVDTLKIIVWVDQLNAYFKYVRDTEERKTEYAAGLLTGHARYWYVQYRKTQGEYTPPWEEFEQELINTFGNQAKEDAYRAFWQETIRKLEETRKETPLNDKVGDGKLKIKEPPTFAGGVDTLKIIVWVDQLNAYFKYVRDTEERKTEYAAGLLTGHARYWYVQYRKTQGEYTPPWEEFEQELINTFGNQVEQRNLCKRLTLCDVKTCTKGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAD1</accession>
    <name>I4YAD1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_60641</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958921.1">
        <property type="nucleotide sequence ID" value="XM_006958859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAD1"/>
    <dbReference type="FunCoup" id="I4YAD1">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAD1"/>
    <dbReference type="GeneID" id="18474070"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60641"/>
    <dbReference type="eggNOG" id="KOG1131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAD1"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="739"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="776" mass="87545" checksum="9287C48F17750E8B" modified="2012-09-05" version="1">MPSGTGKTVSLLSLIVAYQQHYDADRKLVYCSRTVPEIEKALAELKRLMAYRADQGYAAKDSGYIGLGLSSRKNLCLHPSISQERRGKAVDARCRDLTSAHAVQKGRSDPGSHELCSYHEGLSEVAPGEIVPPGIWTIEDVKKFGQQKGYCPYFSVRRMVPFCNTIIYSFHYLLDPKVAEMVSREMSKDAIVVFDEAHNIDNVCIESLSIDLTRPMLESASRSVDKLSEKIAEVKENDAQRLQDEYAKLVEGMQDADQPPPAANDEMAMIRRQDEDVLSNPVLPADLLKEAIPGNIRKAEHFVSFLKRFVEYLKTRMRVLHVVAETPLSFLQHLRDITYIERKPLRFCSDRLSNLIKTLELERLDEYSALQSVAAFATLVSTYEKGFLLILEPFESETATIPNPIFHLTCQDASIAIAPVFERFSSVIITSGTISPLDMYPKMLNFNAIVQESYPMTLSRNCFIPMVITRGSDQVAVSSRFEVRNDPAVVRNYGQMLIEYSKVIPDGIVAFFPSYLYMESIVSAWNEMQILDEVWKHKLIFVETPDAPETSIALENFRKACDNGRGAVMLSVARGKVSEGIDFDHHFGRAVIMFGVPYQYTESRILKARLEYLRDNHRIRESDFLTFDAMRHAAQCVGRVLRGKSDYGLMIFADKRFARSDKRAKLPRWINQYISETSSNLSTDMAISLAKRFVRTMAQPFDHSQTGVSLWTMDHVLERQRLDKESDLAAIANNENDYIPMEVDGDGSGGDSDDDDIDGGINDNALMDIPMPVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAG4</accession>
    <name>I4YAG4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958949.1">
        <property type="nucleotide sequence ID" value="XM_006958887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAG4"/>
    <dbReference type="GeneID" id="18471084"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29170"/>
    <dbReference type="HOGENOM" id="CLU_2135466_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAG4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="113" mass="12932" checksum="003BCE6D4DA39F3A" modified="2012-09-05" version="1">MANSPEKMFRKLSGDDVKVMRSSVPLYLVTAGINAYLQYYNQAFLLEHQVTRWMLEIIGCVLTVIIFKGVMKVLGVFRPETSLINPLSWRLTDDYGIKKPAEPGKPKELKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB60</accession>
    <name>I4YB60_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_29118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958874.1">
        <property type="nucleotide sequence ID" value="XM_006958812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB60"/>
    <dbReference type="STRING" id="671144.I4YB60"/>
    <dbReference type="GeneID" id="18471076"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29118"/>
    <dbReference type="HOGENOM" id="CLU_759113_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB60"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="196"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="365" mass="40824" checksum="B8C2F5D42ED1B2A4" modified="2012-09-05" version="1">MRDFTNAKNHWLNQTQFRKQKVLERAQVWVNEQFELWMNQQLDDVTKTPTHKSIPSSSIQSSGLLTPPSTATKAKMKAPMSPTSPTAQSPYPKDFLKSLTSTPTKLLPNLPSKSRPKTPSDALKRMASYNSSQSLLRTAPVKRSRVKSPSPPPKSIKRAKTLNDEDDVFKTPSKPTHTKEAPQSLTMAERKKNLEASIRAKQDLKLKARGDQLYGNDKESHAIKSQEFQRRSRLSRLPAVAEAVYLWVSFLSNIDIPNKPRLFAPNVSSVASSPSASLPTPTSRKRRARPLQEVASVIVKSSKVAMSAAEAVDSLKMLCNLCPDYLFMRVVDKVEYLEMPTNITEKGYAAMFSKIAKIALKRNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB81</accession>
    <name>I4YB81_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958895.1">
        <property type="nucleotide sequence ID" value="XM_006958833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB81"/>
    <dbReference type="GeneID" id="18474069"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60636"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="I4YB81"/>
    <dbReference type="OMA" id="QVENAEC"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="30499" checksum="5A39CF0F201EB7C9" modified="2012-09-05" version="1">MSKTLQMLDGYQHPIIGLGTYLLKDPDAISTAIKSGYRCLDTACYYHNHREFGLGVKKSGVPRSELFLTSKVDPWTGAVHNARQSILRALNEAQLEYWDLVLIHSPSGGKNTRLNAYEELSSLVDEGKIRSLGVSNYGAGHIEELLASKPKYGPVVNQVEVHTMHSNDKVVRYCQEKGIIVEGYCPLGRKQFFNNRALIEIAKKYNCSVPQLMLSWLIGRGIVPLPKSSDDARQRENLESTNVTLREADMTEINKLDEQMDVDGQYIIQDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC4</accession>
    <name>I4YBC4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_46271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958619.1">
        <property type="nucleotide sequence ID" value="XM_006958557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC4"/>
    <dbReference type="FunCoup" id="I4YBC4">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBC4"/>
    <dbReference type="GeneID" id="18472380"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46271"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_1_1"/>
    <dbReference type="InParanoid" id="I4YBC4"/>
    <dbReference type="OMA" id="RYSWQTA"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="48"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="327" mass="35667" checksum="9A0A8B985DB8F57D" modified="2012-09-05" version="1">MVKRTRKDSKLDDDEEVHALPPSMNAGEPLVSSYSYHSDVPETLLNNKVMMGVDEAGRGPVLGPLVYGIAYCNLDYEDTLKDVGFADSKALTAESRQTLLDKLISLSDQLAWSVRVMSPQDISAGMLKKVPYNLNAQSHDATFSLINDVIAKGVQLEHVYVDTVGPAKSYQAKLEAAFPSIGFTVASKADSLFPIVSAASIAAKVTRDAIIDNWSFLEPISNAISSSKKLKNEDSSVDVSEQQPEKMKLGSGYPGDPNTVAWLKNNLDDVFGLPQLARFSWSTVKNLLESNAHQVTWMDEDENVYKSQLSDAPPSLKKLGVQPISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBM7</accession>
    <name>I4YBM7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1690-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_3898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958570.1">
        <property type="nucleotide sequence ID" value="XM_006958508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBM7"/>
    <dbReference type="FunCoup" id="I4YBM7">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBM7"/>
    <dbReference type="GeneID" id="18472090"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_3898"/>
    <dbReference type="eggNOG" id="ENOG502S4WP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBM7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13425" checksum="B44D26550FF80276" modified="2012-09-05" version="1" fragment="single">PTDQVTLDEQIRNRINSELKRLRNDEYAVRQQIEQELAKENTDKDNSLISSDNVANTIKDIKQKVDRHNSKRDLNNFPAIKSSQSELVSCLTTNKDRPLDCHVQMDGFKQAVADAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBS5</accession>
    <name>I4YBS5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_32616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958448.1">
        <property type="nucleotide sequence ID" value="XM_006958386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBS5"/>
    <dbReference type="GeneID" id="18471530"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32616"/>
    <dbReference type="HOGENOM" id="CLU_2741988_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBS5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="71" mass="8076" checksum="61087AB8F135A9D5" modified="2012-09-05" version="1">MFFHHDVQQVHNNLVKATASIDNRSKGERVNLLHDRARAEHITLDVNRLHGPDDVQGLDLRLELADMVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBU5</accession>
    <name>I4YBU5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958467.1">
        <property type="nucleotide sequence ID" value="XM_006958405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBU5"/>
    <dbReference type="GeneID" id="18475509"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69012"/>
    <dbReference type="HOGENOM" id="CLU_2122966_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBU5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="115" mass="12879" checksum="3B86131AB8FD8BCB" modified="2012-09-05" version="1">MLDHRFTRLIGIALVVIYKVYKSLFVYHQIVTAINLIMYNLLVVESIAVLAFSLDIAYLQELSETSSDLVEGDLESKAGLTVVEKITEKSSSVQTPLNVTEIETQRQMSINTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCC9</accession>
    <name>I4YCC9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">WALSEDRAFT_60350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958316.1">
        <property type="nucleotide sequence ID" value="XM_006958254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCC9"/>
    <dbReference type="FunCoup" id="I4YCC9">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCC9"/>
    <dbReference type="GeneID" id="18473904"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60350"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="InParanoid" id="I4YCC9"/>
    <dbReference type="OMA" id="SKCSDCA"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="22971" checksum="B8D4B5E79343BD2B" modified="2012-09-05" version="1">MYRQGWVTGTGGGISIRDELKAYIAPSGVQKERIKPEDMFVLTVKDRKIIRAPGRGLKESACTPLFFNAFNIRGALSCIHTHSQNCVMATLLWGKEFRISHQEMIKGVRKAGMTDALTYLDTLVLPIIENTPNEEDLMEGMAEAMRKYPDAPGVLVRRHGIYVWGPTWEKAKAQTECIDYLCELGVKMRLAGMRTVPDEGEVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD7</accession>
    <name>I4YCD7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958324.1">
        <property type="nucleotide sequence ID" value="XM_006958262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD7"/>
    <dbReference type="FunCoup" id="I4YCD7">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCD7"/>
    <dbReference type="GeneID" id="18475485"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68895"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543157_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCD7"/>
    <dbReference type="OMA" id="DAVEWCF"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="386"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="502" mass="58460" checksum="2EFC00A871188C4F" modified="2012-09-05" version="1">MQIFSNLFSSIALILVVIYALLSRFIKFLLSPSKQQLPKIRDWDDHSKYKDELITPDVKYYANQSGFDIVDQIITTDDGYHLLVNKVINPKPKFDNLYPILILHGLFQSSGSFITSEERSLAFWLADNGPFQVYLGNTRGVFNMGHQHLKKNDSKFWNYTIEDLANNDLPSLIKHVLLDSNSEHLSFIGHSQGNSIGFMTLSLGYQPQLSKHISSFIALAPAVYAGPLTTGFPFTLINRLNWNRWRFLFGELDFIPLMTWSFNYTPKRAFALLGYQMFAFLFSWTDKNWLNRRKAKMFRFTPSPVSSRSVFWWAGKDGFSTRGCTLDVKQEKWFSSGYQEDNQPKFPPLSLYVGTDDKLVLVEPLLERLKTHESIKLNRLDYYENDHNDIKQFTIDYMNNFDDKPKTRNDNSDKMEDDGFTLVERGGKHGKAANVSGVQVSSKLFNPAENTKKSKFNKPLDDFYRWQRRESKRQEIAGLRLKFQKDKLRIDNFKSNKRYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ8</accession>
    <name>I4YCJ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin nucleotide-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958377.1">
        <property type="nucleotide sequence ID" value="XM_006958315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ8"/>
    <dbReference type="FunCoup" id="I4YCJ8">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCJ8"/>
    <dbReference type="GeneID" id="18473921"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60377"/>
    <dbReference type="eggNOG" id="KOG2530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022511_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCJ8"/>
    <dbReference type="OMA" id="FVGSHIW"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="7">
        <location>
            <begin position="122"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="515" mass="58819" checksum="7C3758447023BCEC" modified="2012-09-05" version="1">MHEIVHLSFGNSSAYSTVQYFNQQEFYFSQEDADQQPIDHDVSYRVGEGYDGSETYVPRLLLYDLKSNFGSIKRVNELYEQDRERDSTFDSISGQQIEYHQQPIGQKSRYQEQLDKGEDPAAPTNDEVRSWTDFNRSYFHPRSIHQIPSFVQSGSTLMEDTGGLVGFDGFKLGQDVYKDYEREHYSFDEDLRHFAEECDLLQGFHVNADISDAWSGFSSAYLEEVRETYAKTPIMVFGHERDHLAPWKASRKYEDIEDDVKHPLSSVLRMNEMLALSRLEAVCDMVIPLSCPTTWRNDYNLKLDSLFVSSSILNPHIDATSLPLKLFNGGTNIQQLSSQLNWRGGTKIVSLCGAVGGTLDAFDYSGINSSKENDVFAQMDVVRPPYKPNQEKLEEKLDSRTKLRHPLISRYWIDKPAYALHPSHSKDIYKDDDLSTLSTLLTSDAVRSKVEEHGKLAESFPFKYGGLGSGLSRDEMIELAEQFWRIHSSYNSDPQFGELDLSDSLGSEGEYELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCK8</accession>
    <name>I4YCK8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958384.1">
        <property type="nucleotide sequence ID" value="XM_006958322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCK8"/>
    <dbReference type="GeneID" id="18475498"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68952"/>
    <dbReference type="eggNOG" id="ENOG502S1UM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067896_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCK8"/>
    <dbReference type="OMA" id="QIGDHEY"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22448" checksum="6D08EB37B8B3E546" modified="2012-09-05" version="1">MRKNYEQGVDNYYKQVHNSYRNPHFYGITKTLNKFLSTFPKPSSIVDLSCGSGEATEIITNFYKRRNEESPSIIATDPFTMSAYTQRTGRTCLPLSFQDIAQGKLEGEFELVIISFALHLISDNSALYSFLTQLSYQSKYLCILSPHKKPEIKQSWGFERLNPLTLEVDQSDTEELYIERVRLRLFKSYNYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP1</accession>
    <name>I4YCP1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958044.1">
        <property type="nucleotide sequence ID" value="XM_006957982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP1"/>
    <dbReference type="FunCoup" id="I4YCP1">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCP1"/>
    <dbReference type="GeneID" id="18473818"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60218"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="InParanoid" id="I4YCP1"/>
    <dbReference type="OMA" id="FRVEQNT"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="96"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="371" mass="42850" checksum="8756C7E71942A791" modified="2012-09-05" version="1">MMTVEEVNGDNNLENNKESTSNKVHPIYHDSSQHRHWRYTPTELADKRRIANEKAIALTRTGWDKEKELNPNSEMSTSITPPSVEEENDLIVYYLSQVKPICNLFQFPEIVEATAVSYIKRFYLFNSVIDLHPKRVMLTSLFLSTKTVNTPISISDFAHYIGKGKISKESILDIEFLISQNLRFEYATHPAHRAVWGIYLDMQTMPSRQNQQVLDGIFAEARQTARLSRLTNAEFIYTPSQIALGCYVMVNKTLVEEYIEWKKQEFHAEAPSFDAIDGVVALINIQKSKGGLKKETVQDIDKRLKLWQDPSKVEGTAMYKRKQEEADKEDLEKRNKRQLEAEKSKYESESVFGEPLETLKRSRTDDGEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCS7</accession>
    <name>I4YCS7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="4">EF-Ts</shortName>
            <shortName evidence="4">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TSF1</name>
        <name evidence="6" type="ORF">WALSEDRAFT_32352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958077.1">
        <property type="nucleotide sequence ID" value="XM_006958015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCS7"/>
    <dbReference type="FunCoup" id="I4YCS7">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCS7"/>
    <dbReference type="GeneID" id="18471472"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32352"/>
    <dbReference type="eggNOG" id="KOG1071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_4_0_1"/>
    <dbReference type="InParanoid" id="I4YCS7"/>
    <dbReference type="OMA" id="QGWISQC"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="5">
        <location>
            <begin position="91"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="290" mass="31267" checksum="FC40693427F737FC" modified="2012-09-05" version="1">MSSKTELVKLLRNTYNCSITQAMAALKDGNYDLTSSKKAIETILERDSTKKAEKALNRGVGSEGLIGTIILNNGFPITTGVPALNRARGGILQVNCETDFVARTTNFKQLVQDVSHTLAFLNESNGFKDIDLNGDILSAPLIQSNPDSTPSTSSNTSIKDAITQTIANVGENITLQRFSGFSLNPATDKSSPFRLLGQFTHNKLQNESNSPVELGTLAGLIDLEVSNTSNESTASSLAKKIARQSVAIPSETLEDFNSQELLGGAEGESVLDHLKSMDAKILDFKRWSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT9</accession>
    <name>I4YCT9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958088.1">
        <property type="nucleotide sequence ID" value="XM_006958026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT9"/>
    <dbReference type="FunCoup" id="I4YCT9">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCT9"/>
    <dbReference type="GeneID" id="18473832"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60242"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="I4YCT9"/>
    <dbReference type="OMA" id="WVPKEET"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="332"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="399" mass="45112" checksum="187C270EA85BD8D9" modified="2012-09-05" version="1">MKSDFIQQSRSQDTNILKPSKPGFRRTYSSNSIKTKQVEVTPASFQKIKLLGKGDVGKVYLVREKKSANLYAMKVLNKREMVKRNKIKRALAEQEILSTSNHPFIVTLHHSFQSINYLYFCMEYCMGGEFFRALQSRPGRCLSESDARFYAAEVIAALEYLHLMGYVYRDLKPENILLHSSGHLMLSDFDLSKQGKEPGGGAPTVKTGTNGIPMLDTRSCVADFRTNSFVGTEEYIAPEVIRGHGHTSAVDWWTLGILIYEMIFATTPFKGTNRNATFSNVLKTQVNFPDSYHHICSSNGRSLIRKLLIKDENKRLGSTSGASEVKQHRWFNSINWGLLRNLKPPIIPNQGNEIDAVNFRNLRESKSIDFDSQVTPTTSKSQITDPFEDFASVTRLTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU2</accession>
    <name>I4YCU2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_54366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958090.1">
        <property type="nucleotide sequence ID" value="XM_006958028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU2"/>
    <dbReference type="FunCoup" id="I4YCU2">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCU2"/>
    <dbReference type="GeneID" id="18472666"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54366"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014033_1_2_1"/>
    <dbReference type="InParanoid" id="I4YCU2"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="581" mass="65039" checksum="6C12AE71820FE046" modified="2012-09-05" version="1">MMGFSGFGKKKTEKKSAISERLDNTKRSADTQDESVKKEENTENVTIESTQGAAPEIPQESVEIPLEIDRKPKVETEKDTNEGDKDDEDEEYETDRDPIPSSHEVVLQDHSKAATAIDLDPAGSRLASGSHDYDIKLWDFAAMNTAFRPFRSFEGCETNHIHDLKYSINGDSILAASGQAIPRLFTRDGDEIYKWSKGDQYIKDQRQTKGHIGEINNCAWHPFDYNLFITCSADSTVRIWDVTEPREQKHVLVFKSKERGTKTKVTACAYSPDGKFIVAVGYDGAMHLWSTAGNYARPNAMNDAAHTKHSWTSSVCFTPDSKYIVTRGGDDTVKLWDVKNIKRPVHVASNLPSLYQEVNATFSPDGKYVLTGVAGVRGESKAFVVVLLTETLAEVKRIPIGKDKGGCVIRTLWHSRINQIIATHSDGGIYVLYDPMSSIRGALMPLDRAPKRARDVEDVLASTDPDRDLRVPIITPDAMEEDERTQKRMRMKKESDARKPQPPLVGSGRGGRVGASATQAMVQRLFGESTIGQDPREELLKYADVDNDPKWTGAWKESGRVYDGETEEQMKERKRKEKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCY3</accession>
    <name>I4YCY3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958127.1">
        <property type="nucleotide sequence ID" value="XM_006958065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCY3"/>
    <dbReference type="GeneID" id="18475462"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68743"/>
    <dbReference type="HOGENOM" id="CLU_2591608_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCY3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="9051" checksum="25CB6CDB2260CFA3" modified="2012-09-05" version="1">MSQKFTLEDKKRFNGTAEHVEDADEKSNSKQKFVDVDEKVLMAEGEDKFTPYIIFVCSTAAVAGFMFGMKLVLLEVLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD30</accession>
    <name>I4YD30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_45627</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958173.1">
        <property type="nucleotide sequence ID" value="XM_006958111.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YD30">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD30"/>
    <dbReference type="GeneID" id="18472366"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45627"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_2_8_1"/>
    <dbReference type="InParanoid" id="I4YD30"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="16">
        <location>
            <begin position="963"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="15">
        <location>
            <begin position="1661"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="17">
        <location>
            <begin position="1998"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2030" mass="230475" checksum="34D6CF293B82F435" modified="2012-09-05" version="1">MKHSDAVDLAALDIQEVFWAKCVAQSAVNSPSHEMLAEGIGLLPPAVAGTLMTQKDNPNKPPQCSFSDVAFPDLLSTSAVSHNVTIALAEESLQVIKRNERTTYLLLVSLRRILIHSGLQAANENWSDSSICQFILVSLNDKSRKVRLAAGRAAHAIIIAQEAALSKKLKGLTHFKQNILFDRFDQLLQMKDPQVAETVLVSVTLIGRSIPIERIYRCLICLFTMLGNMNPLLRSLAYIQLNTLAEHNSTTMYKVCSPHLPQLAVFLVMNMLTAPHMLTDAMSLLGFPDPKAFLHQTLRYTLPSLIAESKKNILLAIARTLGQPVQPLCLEYVEHILAHLYLREGPERDLGIQLFLDEFQGSKKKINLSSVIISCGPSLLASLVMALGDPNEAIARTALDSIDSIEETIAEAENRRSKSKRQKHPDTINGSFLRNHILGIMSIISDNLNDVQGRRSPEEKAKIITSLGVLIQKIGPGVVSVSPQIMALLQGFLEIDNLRSVTLDSLRAFITTLTFKDLGPYIGRTVASFVGNWSAYTPVEAEKAKEILDYMIENARDMSDNAAEMLDMKHIPDLVEQQKKLHSLRSHWTFKDYLENILQRASNENSRVRLHSLIELKEFIKNNKPRFKDLTTGDVFDPIVGNLLRVTLAAADRSGDLQHQIQNAAFDCVGTLGAVDPDRIELQQEEKTMIIDNNFENYDENVKFVMSLMTNELVGAYRSTSDSRAQQDLAYAIQELLKFCGFKPELLQREDNSLPAKVKQRWASFPGQVLETLSTLLTDGRYIAREPKRRPLEYPIYTKCQSYSEWLRLWTTDLIWKTRGKQASAIFSVFKPVVRNQDVGVARYILPYLVLNVLITGEDSDRKEMSLEITEILSDQIKGKDDSTFQDKRLLSAQTIFDLMDHLGKWTRKQRINMQPFQKLATRQRPQRGGTATLTTHQQSQLDMYTHNLNQVNPLIQSIDADLLAHAALRCRSYARALLTFEKRIFEIRPKGDEDNLQLYYEHLHEIYASLDEPDGMEGVSTQIIAPSLEHQIREHESTGRWTAAQSCWEVELQKRPDNLDLHAGLLRCLRNLGHYDTLGTHIRGVLSSHPEWREALGSFQTEGAWIVGDWQTVRENVRNGLAKYSPEYALAKVLLAMHDNDLQRFPAILHDARQHLGTPIIAAGRDGYRRAYDSALHLHMVHELEMIAQTITHFSKLTVSNQPETAQMVAARLTTMLDERLGVTMPTFKSREPLLSLRRSAIGTSAQSQVWAKNEVGALWLSSAKTARKANHFQTAYSASLQADQLGTPFSFIQAAKLIRANGEQDKALRELDAGLSYQVPKLMLKESLKESTNDSKFIDLTNEDDNSTTQSDFNVKYTNLKAKGLLLKARWISEGDRMDFNDVVSHFTDAIKVSKTREQPYYELGHYYDKTAKEDASSDQVYATAIGFTIRHYSQALYYGTKYIYQTMPRMLTLWMDFGERPDILLSDESLAKPSKNDKKHSIWTMFVHIHGQMQKNLERLPSYAWYIAFAQIVSRIGHKNKSVLSILDKIMMKVLKEHPQQALWAIVGMYNSTKANRSERCKKIVATVQKHNETPENRNIIREALTLVNEMLSLCNKSVNQDEWTIHLNKSFPKMVNLAPMNFILPLQSSMTVTLPATNKHSNSHQPFPDKPVRIYKFVDEVELMRSLVKPRKVTIIGDNGIEYNFLCKPDDDLRKDARLMDFNSMINKFLKSNSEARKRSLGIRTYTVIPLNERCGLIEWVKDTRTFRSILIERYEYRGIKWYSPDIGNMLERGRTNGPEQTIHMFAQVLKRYPKVFHEWFIEMFPEPSEWLKARMTYSRTLAVMSITGFVLGLGDRHCENILLDKNNGAVQHVDFNCLFEKGSQFEVPERVPFRLTHNLVDGLGVTGTEGIFRKAAEVTMEILRANRDSLGSVVESFLHDPLVDWEDEKRRNDRLRAMEKSGRRPVGTSRKATGFDQDVDGQAYIKQLAMSALGPIERKLQGLQTEHDKANKTVMSTSAQVEKLIREAASPYNLGAMYVGWAPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD95</accession>
    <name>I4YD95_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate resistance ArsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_17998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958022.1">
        <property type="nucleotide sequence ID" value="XM_006957960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD95"/>
    <dbReference type="GeneID" id="18470749"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17998"/>
    <dbReference type="eggNOG" id="ENOG502QQY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_0_1_1"/>
    <dbReference type="InParanoid" id="I4YD95"/>
    <dbReference type="OMA" id="RPMPTHR"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="220" mass="24906" checksum="F73DC297B526178D" modified="2012-09-05" version="1">MLATLPQKLNVLILYGSLRQRSYSQLVSFEVARILDHMGADVKIFNPSGLPLKDDTTDNHPKVKELRELIAWSDSNFWVSPEQHGQITGVMKTQIDHVPLSLGSVRPTQGKILAVAQVNGGSQSFNAVNTLRLLGRWMRMHTIANQSSLPKAWTAFSPDGRFLPSSNRDRLVDVCEEFIKVSCLFYGKTDLFASRWSERKEKEAKGRLLSQEEKEVKKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDA3</accession>
    <name>I4YDA3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_54193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957757.1">
        <property type="nucleotide sequence ID" value="XM_006957695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDA3"/>
    <dbReference type="FunCoup" id="I4YDA3">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDA3"/>
    <dbReference type="GeneID" id="18472653"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54193"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="InParanoid" id="I4YDA3"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115040" checksum="58FF253FB0E56E68" modified="2012-09-05" version="1">MSKKFADKDSTRNVRNLCIAGHVDHGKTAYADSLLAANNIISSRMAGKLRFLDSREDEQQRGITMESSAVSLGFKLLRQGEDGQAKAEDYMINMIDTPGHVDFSSEVSTAARLCDGVLIMVDVVEGVCTQTISVLQQAYADRLRPILVINKMDRLITELKLAPSEAYHHLVQLIEAVNAVIGSFFASDKLADDYRWRELSEQQRGAFVERDDQDLYFSPEKGNVLFASAADGWAFRVSKFAQIYAGKLGCKEDVLRKCLWGDFYFDPKTKRLIGKKAVGNRPLKPLFVQFVLDNIWAAYDAIHMNHDMEKVNKIINALNIRVHPRELKTRDTKTLLFAIFTAWLPLASATFSAVVDVIPQPSQAQSLRLPKMLYPLEHHPSSIAKNDVERAIYGSISDNAPVVSYVSKMFAVPANELPENRRRGLTAEEMRERGRESREKAMAVSAALGATGMSGADELSLEEAAKREQEKDTQNDEKGEGQEEQIEESMIGFARIYSGNIRVNDTLKCLLPKYNSEVPPNNAHNLKHVQDITIKSLYMMMGRDLVPVSEVPAGNVFAIGGLDGVVLRNATLITPDNDNCFINLASVVNQVAPIVRVALEPGSATDMGKLVNGMKLLNQADPCVEVLQQETGEHVILTAGELHLERCLKDLRERFAKCSITPSKPIVPFRETAVKGQEMQPPKTKDAVRGTIHASSFNNIVTFTVRSAPLPKQITDYLIANQFSIKRMLGVSLDRKQDDDEITVEDNTSSLEAQDTYKPPNVIWEELENLFSNSGYDWKNVVDNIVAFGPKRVGANILVDKCANRSLRNKTQIDDRWQKMVDESIENGFQTATNQGPLCAEPMVGMAYFLEKVEIEDKEGLEFNTSQTTGSLISSSRDAIRNSMLDWSPRLMLAEYSCEIQASTEVLGRVYAVVSRRRGRIIAEEMKEGTTFFTVKSRLPVVESFGFADEIRKRTSGAASPQLIFSGFEIFDIDPFWVPSTEEELEDLGVLAERENAAKKYVDLVRERKGMFVERKIVAEAEKQRTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE0</accession>
    <name>I4YDE0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding domain of Mlu1-box binding protein MBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957792.1">
        <property type="nucleotide sequence ID" value="XM_006957730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE0"/>
    <dbReference type="STRING" id="671144.I4YDE0"/>
    <dbReference type="GeneID" id="18475407"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68479"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066298_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDE0"/>
    <dbReference type="OMA" id="GEYVENS"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="32218" checksum="6BD83AC8F1BA0C39" modified="2012-09-05" version="1">MTNKVQELWWEENKTRVWQVEVDNGNYVARRQDNDQINGTKLLNITKITRGKRDGILKNEKSRQVVKTGTITLKGVWIPFERAIILARQFNIEQQLYPLFETNLGDYVENSIGSHQIKRKSLNNLMDSLTTNRELVSKRRSTVSTYNPATSAYVSPYGFSPQHCYQTEFEDMNQHSGEIQSGRPRNTSSASDWMTNWSTSSSSPVIPATPNTFSPVMNTFQSLALHSPPIPIPNYYYDSSSSYFPSYHQKQQQQQVQMQMQMHTTASIGGDRQSNEYIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDN3</accession>
    <name>I4YDN3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_54263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957879.1">
        <property type="nucleotide sequence ID" value="XM_006957817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDN3"/>
    <dbReference type="STRING" id="671144.I4YDN3"/>
    <dbReference type="GeneID" id="18472661"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54263"/>
    <dbReference type="HOGENOM" id="CLU_1120846_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDN3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="28629" checksum="641B259C26A1263D" modified="2012-09-05" version="1">MSPKRVRFGPREPQLNSPAGAGSPALPMSPLLLFPEPDEGPAPTPPPPPPANDDNQKPNGKKKGKGKGVQRKPVPKAETGGNKDSETPKDDAMPLSPLALPMANAEDEPIIEDLFHEIERDTKILKEEQERSKEKEKDDTKEENKEEKNDLSMNAPSAGETSASEPERRRRAVETNQRRRQRKKRLINPQNQIRYRQHQTHHLRLRKMNSRWQKAILFLNHQSRPSYHRCLNRLRKNYLRRRPRIRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP5</accession>
    <name>I4YDP5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957891.1">
        <property type="nucleotide sequence ID" value="XM_006957829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP5"/>
    <dbReference type="STRING" id="671144.I4YDP5"/>
    <dbReference type="GeneID" id="18473781"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60162"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005387_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDP5"/>
    <dbReference type="OMA" id="RDQHPLI"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="274"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="498"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="671"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118183" checksum="AD2E0E6F92CE17DA" modified="2012-09-05" version="1">MSYYGESDTTPNTPNIHPSTSRLNYRRSFRHPQPTPPPVPARPHQYASTSAINEEFTTSVLKRNVQPLRVNKKDSNRPQPVTPISPMISDNYPSDNASLSPASVVRRPTSHSRTSSVYSMESRVEPFYGRHTDDEHDAMFNQLTIEEQEQQDLSQAIEMSKSEVSQPFSVDDNDQSTVSSHLHSAGSSIGESRQTYNTPDTTAYNTSDEHHNGVPSDVTWNQDESTFVKKERMRQHVENHNLKKWQSDMEDVTSEWHNLVSDDTLKAFGKVEIARQSVLFEFMRTEKMYYNDLHFLEEVFVPPIRDSNMIPEERRAQFVKDAVFNLSNLVANHKRGLMRIFERQNEEHPLIESVADLILRACIIWQDDYEAYIKHWPIQEATLKAEMRNNKKFADHCEACSRHPKAQRQSIIPLLQRPVFRLPRYPLLLNRMLDNTPEDHSDRENLPVAARAISDIAKSTQPGIEQSNNKVKFWEMASSLDFRLGELHDVDLLDDIRTLQHDGILFKRERSATDLHGWHAKKVFVMDNYVLITEPSQKKKTDAIRYSLTSRPIPLELCHIEEVNPSPTHRTNCLLSDERRSDGSRILFTHIEPEREVHGMVLKHVGNGKEYKLYASTASERDTWKFKISEAIAIRRTFIEANKLIVSKTLTNSIFQQSVLSQADKYEKSGSNRINSASMFKWGSRNYVSLATSSGVYIGYEDDKESYRKVIGLKGVEGVTVLSQYSLMILLVEGQLYGYDLEEICPTSSRGPKRKFGRIRLCSSSEKVTYYKVGSTIGKSAIITYVSHKVLHKSTAQFFEPLPVNARLQAYQDVNRVKKPKREVWIREVMPALSLQTTGIATVLFPFPSSKHVAVIDEGVLRVLDPTNSNRMLTLPRLHGHNYQVFKDRHQARQYQLNIANISDQISRGKLKPIELFTVKSGEYIMIFDTLGLYVNEKGVPLKSANVLRWNGTVNNAAIEGNLLLLFCETFIEIRDKRTGKLSQIIRLHKDVRLASQNSLRGEDMVVVERYARSHKPYGLFDHAFKLTCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU4</accession>
    <name>I4YDU4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_68602</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957936.1">
        <property type="nucleotide sequence ID" value="XM_006957874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU4"/>
    <dbReference type="STRING" id="671144.I4YDU4"/>
    <dbReference type="GeneID" id="18475436"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68602"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDU4"/>
    <dbReference type="OMA" id="WPADHQG"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698821" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="29036" checksum="078D87672B0FCB90" modified="2012-09-05" version="1">MKFSSFLALAATVAGISAHGVPQSFTINGQGYPAYDPQVDPWQPHAPKVNRPMSDDGPLYSKDDPMLTCNKVGTQTPAEMTADAAPGSPFIIQWDRWPSDHKGPVLTYAKFCGPGHDDCNNVQDIVNGWFKIDEAGYDANTGQWASDQLVAQGASWTLNLPPAENIQQGSYLIRHEIIALHSQGAPQFYPHCIQVYINGGTGSLQGQSVSIPGNVYSNAGDDGTLFGSIYSADVSSMSIPGPTLANGAISNAYQKREEPVARRRHHAGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEG8</accession>
    <name>I4YEG8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_37154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957614.1">
        <property type="nucleotide sequence ID" value="XM_006957552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEG8"/>
    <dbReference type="FunCoup" id="I4YEG8">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEG8"/>
    <dbReference type="GeneID" id="18471999"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37154"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEG8"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="250"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="454" mass="51358" checksum="A7A1BA9BFEE27027" modified="2012-09-05" version="1">MGRELITLQAGQAGNAIGHSFWQQLCQEHGISQDGTLEDYAQDAGFDRKDVFFYQADDDHYIPRSILVDLEPRVINNILSSPFANLYNPENIYVSQDGGGAANNWAMGYHAAERIYDEVFDMIDREADGSDSLEGFMLLHSIAGGTGSGLGSFLLERLNDRFPKKLIQTYSVFPNNQETSDVVVQPYNSILALKRLVNHADSVVVLDNAALSRIAADRLHVQNPSFSQTNQLVSTVMSASTTTLRYPGYMNNDLSSIIASLIPTPRCHFLMTSFTPFTSDQIEKAKSIRKTTVLDVMRRLLQPKNRMVSAPTSKTSCYISLLNIIQGDVDPTDVHKSLLRIRERQLANFIPWGPASIQVALTRKSPYVPSSHRVNGLMLANHTSIASLFKRVRDQYDRLMKRNAFLEPYKRERMFSNNMDEFHDSREVVQDMIDEYQASERPDYTEYHAHQDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP9</accession>
    <name>I4YEP9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957683.1">
        <property type="nucleotide sequence ID" value="XM_006957621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP9"/>
    <dbReference type="GeneID" id="18471425"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32133"/>
    <dbReference type="eggNOG" id="ENOG502RZN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1866696_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEP9"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="137" mass="16402" checksum="40EB8EEC46E626FE" modified="2012-09-05" version="1">MDKYFEADYDPATDINLPDNATDQDFDSWNVMLDNVRERNKLKQQREAELWEEEKRKERERENIKLGREKAKIAKLLGPDAEKEYQKRKKEAKRARKEETKEMIKSQVISSIDNESTLMSMQYNKRGTTREWDVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEQ5</accession>
    <name>I4YEQ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Chromatin elongation factor SPT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957688.1">
        <property type="nucleotide sequence ID" value="XM_006957626.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YEQ5">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEQ5"/>
    <dbReference type="GeneID" id="18471426"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32137"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="InParanoid" id="I4YEQ5"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1345"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1433" mass="161574" checksum="4AEF7436B2B30CE2" modified="2012-09-05" version="1">MFNEDANRAMEDDDDDDLGNFIEEDEEDPRNAYAGGDDRRKKKKKQKARKNQRGILSEQAGVDQETMDEIYEVFGDGTEYGWAMEVDEEEEFEEHRGDTKMADVFEPSEIKARLMTDEDEIIRYTDLPERMQLLTPGIAISNVIRDHYATDTEYAHRLPDKDKSAAWIAPRLSEASKNMFLDPLAPHYNLKDEFIRAVTVAVDSIQNGMEVPFIHIHRRDLVSHFDPAKTSVPLAPEELRHEYPAGTSAVWRNRHQMSLLSRSDLWKIYELYRKYVSLHIRLSGITELAEKAHIVDNYFTGTLVPLAQDEMEVTNDLHEWLLGMYPHEIKILQDEQRSMSERQFKRPTKASAYERAKKMPSSELIKKVVPTVAEVAQNLRSEVGKLFTPPTPSLGPFDLAETFTVGSINSQMMLSMAKLIFITELGRDPLIKKHVRDRLTSEGIVSVLPTDKGLNKVDDQHPYNRFLYLKNKPIDKLSEDSTQFLSILAAEKEDLITVSIGFHPDVQEEIIDRIFEATKGEDTGEVSEAWNTFIRDAIFEAFEQSLLISARKYAREWLREKQEDYLAQRLTDRVSQRIDVAPFTAPGWEKGETPSVLSVSAGQGDPRKDAILLVYLDEDGRLREQQKIDNLVDETTMEIFSDILKRREPQVVVVGGMGTQTHGLYQRVLELVKTQTGEQIDPNSQVDEWGEPMVTDEGQQPTINPESGTPVIFVNDDIARIYQHSKRAELEFGELPLTGKYCVGLARYAQSPLNEFAALGEDVTAIAIDPDQRLLTNVKFLQAMEKAFINTVNHIGVDINIAVRDTHYQHLLQFVAGLGPRKAQALVRRIAARGGYITNRSELAHPDLMYLKEFTNAVAFIKITQEFDSKVGDELPDVLDQTRIHPEDYELARKMASDALELDEEDLEGQHESAVVKQLIDDKQNESKLDELNLDDYALNLLQFRGDYKRSTLNLIRDELLNPFGEDRDDFKTPENKDIFTALTGETDQTLSPGTVVPAVVKATKPQFAYFRLDSGVDAFVSSVYATDEGDPDRRMDSIFPKATTVQGMVLNIDYDTFQVELSTRPQDLAMAPEYRKIVAEDEYYDTIKAMEDRESAQRRKQSKANRAPRVVDHPNFHNFSAEQAEQLLEGVPRGEVVIRPSSKGSDHLVVTWKVDEDLYQHIDVLEIDKANEWSLGRLLRIGNATYTDLDEMLVMHVQPMVRKVEELINHEKYHGPTEDDMAKYLHDFVKANIDRSNYAFCLDRKDPGSFVLGFMASAKSALNRWSVQVTPGMYVLNGAQLPTVADLCRAFKLQYADILKNPRSRLANGGKTPFAGGRTPATGARTPARGTWSATPAQGKASAWGGGNRTPAAGWGGGRTPHHGGRTPAINHGGRTPAQAVQAANANWNNNSSWEAPGSEGWNNSAPTQGDSWNTSGDASTASWDNSRGWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV8</accession>
    <name>I4YEV8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957174.1">
        <property type="nucleotide sequence ID" value="XM_006957112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV8"/>
    <dbReference type="GeneID" id="18473557"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59794"/>
    <dbReference type="HOGENOM" id="CLU_1391215_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEV8"/>
    <dbReference type="OMA" id="RIHTHRI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="196" mass="22277" checksum="EE15D8C674469B82" modified="2012-09-05" version="1">MRPRGIVGLKYAKPFDSVLVEMSNEHLARQIDLINSRFAVEQTLANYVRRVDERAAVELSELFTEDSVTQLYVNENGTDVAFRPPLIGRQGVISAVHKQMNKQWKGKWGHHSTSNILIDIDLETRTAKIDAQLVVLKSLQAPPPENVEEGSILFLGTVENVNSGYYKSRLREIEPGVWKFYEHGVVLDLSPHYTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF38</accession>
    <name>I4YF38_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_56779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957250.1">
        <property type="nucleotide sequence ID" value="XM_006957188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF38"/>
    <dbReference type="GeneID" id="18472850"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56779"/>
    <dbReference type="HOGENOM" id="CLU_539912_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF38"/>
    <dbReference type="OMA" id="DICLEYN"/>
    <dbReference type="OrthoDB" id="10466074at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="58611" checksum="8CEC2D4DC92762F7" modified="2012-09-05" version="1">MEVTIKPSLGDMNPDILMQIIDSAHEIGIYDIGHTLAQVNRYLASIVKLYSRSFSALTLEVRNNIARTLRKFHFNQMRSNSNNIDRLKLDVFSNTGFTQLYNTGLFSLINDSRPLKNLSLIGLCQDFRPHIPVEAEEISIDNTWDNSLVPQYAVICLYSRNTRSCKRLSLKNVTIERDTYDVITNCKNLKLEYTDKCPRGFNSQHFRANRSGLSGTVLAVTSLFNNLKSFTIINSTDQMFFSTCTYQVRGFPVSTMDELEELHLVRVNTFICKIRTCKLKKLKLEGCTDLENQFRKLNPRLRFLSLAHSRFGRITRLVRYDLLRCVELQTLDLSYADDEFVDIFVKDKKYLRGLKELVNINFSGTNVEGQDVLSCVRRHYPDFEQLKAINCPNITIEEQLELIENVPLCQVDINQHVNRELVFENPHPSAYLYKRSRWLYIGHHGSYYRQAQYTEIEFPQVMPPPPNEIHDTPTEELARYEWRRCTPPSPPVTYNSIVDENTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE2</accession>
    <name>I4YFE2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957348.1">
        <property type="nucleotide sequence ID" value="XM_006957286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE2"/>
    <dbReference type="STRING" id="671144.I4YFE2"/>
    <dbReference type="GeneID" id="18475351"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68127"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012487_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFE2"/>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11610">
        <property type="entry name" value="eIF2D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048247">
        <property type="entry name" value="eIF2D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="483"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="569" mass="63070" checksum="BA56D9DE4E53975B" modified="2012-09-05" version="1">MSFKKAFSAKPQTTLKNSDRKKLRSKIQERFQLNDDDAKLLVPDVVSSMKIKTYNDENGLVYSAQNNDPLWYTVGKSEDELIPSVYTLFKKPSLLPVITTWSFVIDKISTGADLMAPGIALKSNPSQLPDVKEGELVAIAEHGPNLAPVCVGKTAIPTSRMTLDATGKAVLISHSINDALWLAGSQPKDIPEGGRQDGHFDDSEDEADGPVETLTPQVDNLDVKDDRDYQNVQLSVKEVDDILKNALVHAITTSLKDAELPMQASTLLSAHVLPSRSSRVDPGLTDLKSSSFKKATKFLKAMEKDDLLSFKEQKSNVIITRLNNTHPLVKGWRGHKTLAVAEKQVEKRSKQESLPSETRTGYLVEDVYLAKGVVRDWLAHAGVDPDEYYTSSELRAASNDFIESHNLIHPADHAYVLGKQNDILASALYAKPANQKKGKITYDDVDFVPRQEVTGRLVQHMQPFTRLTNGTNSRLIKGHINNFALQIKQRQGRKVTSHLSGPFKEFELKLDDLANELKVICASSTTTGPMQNNPKELEVIVQGDKIKIIIDLLKSKGIPSRLIEIVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFH5</accession>
    <name>I4YFH5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_44397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957378.1">
        <property type="nucleotide sequence ID" value="XM_006957316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFH5"/>
    <dbReference type="FunCoup" id="I4YFH5">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFH5"/>
    <dbReference type="GeneID" id="18472328"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44397"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367695_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFH5"/>
    <dbReference type="OMA" id="ASANTHK"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="41"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="600"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="868" mass="96763" checksum="F6D1C49C18965A91" modified="2012-09-05" version="1">MAYMRPDYIPHSQLVDSKHAMTYGLYLYRDRAWNLNNDISPNGVPVLFIPGNAGSYKQGRSIAAELAKQYYSSYGIPNSYLESQAGAPPDFWTVDTNEELSAFHAGTIRRQAEYILAAIDYILNQYTHQNQPPESIIVVAHSMGGIVVNELFNLPEYRTGLVDLVISLSTPHAMPPTPFSRNMASLYDQRYNASVNIAVSGGSADSLLPADVTYAPIGHNSLSILSTSIPGVWAPISHQAIVWCDQLRRKLARAVLLSIDSNKSTKLKPKESVLNIWQKSLTGIVYENTLNDTFDVDINASMSSGTFTAVNITRNSAAWSLGKPPPKWVTGDVAPTIRLLTDISPEPAYKEFEEGEPPITILGCKNVRPLHSCRHLSIKDSAVMPYLPRDEKWLPVRHGADEEQSLYMLDADSDTLRDDESVVVLKTNNNRKGSWMTSQFAPTNEETRVDASFARLLFSSVPLISQTSGMLALRRNYRVVNAPATSLLVYKIEAEQSPCVSTQFNKKELFQPLLKHVVESTKGLELTYHPSLNGKIMLESHLSHSPYLTSGRASNDAGLSLEIFADTFNTESCFPFQKLTIGVDILASIAKWGTRYRSALIGFALGIWCVAFRRQLKALDSSGTSENFIKSLTMVFRREMIVFSFVLVISILVSSSYSSLTLYFIGLHDIRLWFIAPLLLLASYGLVSGASVVISILSMVFSLARIRLPQFASSRKVEIVLVILNITIVLVIPQQVMLSFIGILSLFAGNSNPIAMSIKVLIILLSPFYIPMTIVWIKDPLISLFGLDYEDHNPLLAIPFSLMVYFLITNKQVNRLESSQSQRKTWLENIAFFLLSVSALIFSGRHAYIVNEMICILIFIVIYTRFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFH9</accession>
    <name>I4YFH9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_59907</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957382.1">
        <property type="nucleotide sequence ID" value="XM_006957320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFH9"/>
    <dbReference type="FunCoup" id="I4YFH9">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFH9"/>
    <dbReference type="GeneID" id="18473620"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59907"/>
    <dbReference type="eggNOG" id="KOG2173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006200_3_0_1"/>
    <dbReference type="InParanoid" id="I4YFH9"/>
    <dbReference type="OMA" id="IPTGECV"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM22721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="705" mass="81185" checksum="9603AE15E9C83FD7" modified="2012-09-05" version="1">MDFSTPILNMLMNSRRSHYDPIDDQEQDIQETVELNPRHTDDDDGPPASILVEGEQRNSLDDNPPIKYTHSQQDTPLPLHQHRPVSRGMSPYQLAMWKWVNVQNLDKFLQDAYSYYLNKGIYCIVLTKALNLATVGFVFLFSTFLFGCIDYSAISHDGSLSDIVIPHCASSFSFITWIWLLAFGIFYIYQVLTFILSLKPLVDMYRFYTHILRIPNTDVKTISWEEIVSRISHIRQSNPLTAISSVGVSHGPVAKLDVLDVANRIMRQENYLIALFNKDLLNLDLPIRNKLLKKVLSFATSNGLTKTLEWNLSFALLGHVFDEKGQVKAHILQSSSRGRNVQELRKRFAILAFVNALLAPILVIFLLFYSFFRYFEEYHKNPSSIGSRSYTELAQWKFREFNELQHLFQKRLSLSYDDAQKYIVQFPNSEIAIIARFVAFVAGSFAAVFILASVIDPDMFLHFEITPQRTTVFYIGVFGTILAVARGMIPADNEVNDPERLLRRACAFTHHLPKEWEGQMHSKKVHAEFSRLFELKIAIFLQEILSVLFTPIILYYSLPKSSPAIIDFISQSTVHVDQLGYICSFAHFDFLRHGNKRFGAPKDAQNVKLMSEDGKLEKSVLNFKAANPKWMPNDQAGSIFVNKMSESIMPSKRTMKSPEMGLGEVYEDEREWDNNERRESDQGVLKMFQQFSFSRTRTNNFPRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ4</accession>
    <name>I4YFJ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957395.1">
        <property type="nucleotide sequence ID" value="XM_006957333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ4"/>
    <dbReference type="FunCoup" id="I4YFJ4">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFJ4"/>
    <dbReference type="GeneID" id="18473624"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59913"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="InParanoid" id="I4YFJ4"/>
    <dbReference type="OMA" id="DYGQQNI"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697764" evidence="7">
        <location>
            <begin position="17"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="839" mass="92209" checksum="58E6CC72F9E55C4A" modified="2012-09-05" version="1">MRVSIILLAIVASVYAAILSLDLGSDSIKIGLIGSGNLDVVLDKDSSRKLQSTVGFKNTERLFGKQALQNSNRNPESSFSNLKLLLGKSEHSDSFSRWNSIWSAAKWSPTDRGTLALHTPTDSFTVEELLAMQFQYAKQLAENEAGEAIKDVVLALPPYYSSYERQAILDAVNLSSLQPIALINDGTAVAVNYAMTRAFDATPSSYIIYDAGASSLSATLLEISSVAPPKKRFGNNQNTTVINVIGTAYDSGVGGVDLDHRLREILANAFEKQHKLDKSWRENKRAWNKLLVEAGRVKHILSANTEAQSTIEGLHDELDFKTKVSRDEFKAAISEYEHRWSAPIGEVLKKTGRDINSVNSVILTGGASRIPVIQSHVRSDVGDEKISTSVNADESAVLGAAFYGATFSKSFRTKPFVVNDASDFSMEALENGSTTPLWIEGDSLPVNKTLVLPPKDTEVIVQYTANSVPADQKAPYMQLTLKGVEEALQDINLSYDEAIASQVRAELTVEQTAFSLVFPVGADLVVPAPASSEGLTGKLKEWFSGNANATTEQASPPEEKRIKLDISSLPVSLHPMTVDAKGASIEKLTKLNYAEKLKALREESFNGLESRLYVLKDVLANDEEKFGAFHNVTQAHELEELKKAHSEALEWVDSEGWSATLEQIQEVASKISSLETPIKERLKKQQVKAAALGDLQKALFAGRTFLQQARKNLTTTDESRYTFKEIDDFEAHLFKTENWLRPLMRKDEAAKPWEEGAYNASELEKAGRSVQDIFMELTNRKPAKKTSTESASSTPTSSATEKSTTSESATSSSTEEEKTSTKEAEKGEETHDKHRHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ6</accession>
    <name>I4YFJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_68167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957397.1">
        <property type="nucleotide sequence ID" value="XM_006957335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ6"/>
    <dbReference type="FunCoup" id="I4YFJ6">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFJ6"/>
    <dbReference type="GeneID" id="18475357"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68167"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFJ6"/>
    <dbReference type="OMA" id="CHKNIVE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="30189" checksum="835347516FDAE74A" modified="2012-09-05" version="1">MSANHLSLVADIKNKNLNLNVIKQLLVFINAHLSNSDLNSASIHINTSILLDTQEDDIGFGDISERFIRYVNNYYVGCRNDVSTASSTLASTLAQSLCHVNRKIVQESKSTFRILVVAASDDVPPEYVSLMNSIFAAQKSKIVIDVVQIYNCNTIFLQQAAHLTGGNFIQATDPESLVQYLIMAFLPSQPLRARLVQPRSDKVDFRAACFCHKRIVDIAYICSVCLSIFCQPPQRCSTCNSVFPAKTLQKFTGSLQTHSHAPFQPSSLRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFM9</accession>
    <name>I4YFM9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_27998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957428.1">
        <property type="nucleotide sequence ID" value="XM_006957366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFM9"/>
    <dbReference type="GeneID" id="18471020"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27998"/>
    <dbReference type="eggNOG" id="ENOG502QTP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471892_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFM9"/>
    <dbReference type="OMA" id="SHAECEP"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="235"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="578" mass="64337" checksum="FCD6F6D2051FEEB8" modified="2012-09-05" version="1">MNLQQSPTKVVKAPTPPPVNIKSIDEIVKMHAPLLKVETQASKDAERLAHTRITSDNSSVNRTLASSPSPSHSPSMTDARSELDADRPTIKSIHDIIKEHSHSLSSKHSEGFDYDDSDNDDEQDIQIDIEGFQPRDEKRNGIYKPSYTHSSYSVHSNNKSPSSSTRTPSINKTPVIDKPYEDEFDIDTVPSLASKSWIAQYLRSPRLTRLIKLRRFPHNGLQVSLADVGKKDGNPVLVFLGLGCTRHLISLYSDLANTLNLRLICVDRWGLGRTDPSTSDKRGLIEWANVIVEILDVLAIKRVALLAHSAGTPYALALAYTAPNRILEPVQLLAPWVQPSASPKGNWKWLKHVPNGVLKAAQAAEWRVAGWSIGKPPQLKYEGVENKQSDEEVIDEFAYLDQADGFDESVFERSHSQPNVQTLSATQAPQRSSSTQNLKRSRKVSLNSSTRSGQESTSDEKQVSVGSALLAASHAESQSGGGTAHDLMLILNRGNKPWGFDYRDITARVHIYWGDRDDRISYEAVKWMEDNMVSCKLQHLPGKNHSLLTDPIVIADVLENLAEKYNNRIKDQQKKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFQ4</accession>
    <name>I4YFQ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_28015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957450.1">
        <property type="nucleotide sequence ID" value="XM_006957388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFQ4"/>
    <dbReference type="FunCoup" id="I4YFQ4">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFQ4"/>
    <dbReference type="GeneID" id="18471021"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28015"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="InParanoid" id="I4YFQ4"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="377"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="589" mass="66204" checksum="B806F1DFBAD8812D" modified="2012-09-05" version="1">MCGIFGVNGLKNPAEYRSKCIECAKAIRHRGPDWSGVHQGKDFIVAHERLAIVGVDTGAQPIVSEDEKIILAVNGEIYNHKQLRQGLKNQDALFKTHSDCEVIIHLYREHGIQAPALLDGMFSWTLFDTNYPETRVIAARDPIGITTLYQGWNSSKPGAVYFASELKSLHTECDKIIAFPPGHVYDSLTGKTERYYNPPWWNGDNEDAPAPTQPADLKILRESLENAVRKRLMSEVPYGVLLSGGLDSSLIAAIAARETEKVQKAQYEARKARLEGTTGPSKYPEQDEERTLAAWPTLHSFSIGLPGSPDLLAARKAAAFLGTTHHEFTFTVQDGIDALKDVIYHLETYDVTTVRASTPMYLMSRKIKAIGVKMVLSGEGSDEIFGGYLYFHAAPSREAFHQELVKRIKNLHTADCLRANKSTMAWGLEARVPFLDKSFLNEAMAVDPQEKMFNKDTLKNLDAEGRSRMEKYIIRKAFDIEVDGKPYLPESILWRQKEQFSDGVGYSWIDGIKDFTAEQVSDEKFEKRAERFPHDTPDTKEAYWIRETFESLFPSKTAAETAVRWIPKGEWGCSADPSGRSVSIHEKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU7</accession>
    <name>I4YFU7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A1pp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_43658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956891.1">
        <property type="nucleotide sequence ID" value="XM_006956829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU7"/>
    <dbReference type="STRING" id="671144.I4YFU7"/>
    <dbReference type="GeneID" id="18472300"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43658"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_1"/>
    <dbReference type="InParanoid" id="I4YFU7"/>
    <dbReference type="OMA" id="AKWVIHT"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="171" mass="18474" checksum="135CD06672BA47A2" modified="2012-09-05" version="1">MSVIGRISLLRADITKLGDVEAIVNAANESLLGGGGVDGQIHKIAGPQLLEECRTLSGCKTGDAKLTKGYNLPAKYVIHTVGPRFTNSNREELLRSAYRRSLEVAHQNGIKSLAFPSISTGVFGYPIEQASVVAIKTVKDFLDAHKEIEKVTFVLFSEGDLSVYKDNLNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX7</accession>
    <name>I4YFX7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956918.1">
        <property type="nucleotide sequence ID" value="XM_006956856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX7"/>
    <dbReference type="GeneID" id="18475293"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67758"/>
    <dbReference type="HOGENOM" id="CLU_863828_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFX7"/>
    <dbReference type="OMA" id="SHANSPW"/>
    <dbReference type="OrthoDB" id="3355242at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="322" mass="34403" checksum="B41C2416CCF4A29D" modified="2012-09-05" version="1">MITRITKVNTRYLSTSIRALANKPEDVESHTNSPWQTSIKEGQATKEYPGVKPSNEADKQALGSAAADQVGGQPNGHTSAGETHDVPEPGLKDKFKKALGMSTETESKKGRTYTTLARQFSSTSAANKAPNEPKEETNNEQSGHINHRRASDSQPLHGADATGKPARYSDAIANEEGLHGPARGGYVHALPSAEAESQGKSSAYPSNDSVVTENYPAADLDRVKPSGAAPGSSTVSHQIPESVRESVTRTTDPDALGSSNRLRHGQAPGKDFDGEGSLMNDVPRERVEPNTELGKRGVTLPPPPRTQEELDKLHPGRKNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG56</accession>
    <name>I4YG56_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DCP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_50472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956993.1">
        <property type="nucleotide sequence ID" value="XM_006956931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG56"/>
    <dbReference type="STRING" id="671144.I4YG56"/>
    <dbReference type="GeneID" id="18472528"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50472"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008108_3_0_1"/>
    <dbReference type="InParanoid" id="I4YG56"/>
    <dbReference type="OMA" id="PIRLCFQ"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="220" mass="26199" checksum="82C58C091DFC2A32" modified="2012-09-05" version="1">MEEIFLNLSTKFIINLPLEEQQSLERLCFQVEAAHWYYEDFIRECQPELPSYHLKQFSQQFFKYCPLLSKNYHLHEKAFADFIRYKTRVPVCGAIILNPQYTHCLLVKGWKQSSAWSFPKGKINLDEQHHLCAIREVLEETGYDCTSKLIETDFIDVAIKDQKIRLYLIQNVDMNTEFKTQTRKEISKIQWFKLTDLPSWNKNTKHISTSKFYLITPFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB3</accession>
    <name>I4YGB3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_27695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957044.1">
        <property type="nucleotide sequence ID" value="XM_006956982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB3"/>
    <dbReference type="STRING" id="671144.I4YGB3"/>
    <dbReference type="GeneID" id="18471006"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27695"/>
    <dbReference type="eggNOG" id="ENOG502QUVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039338_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGB3"/>
    <dbReference type="OMA" id="CTIARYN"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47242" checksum="80BBE336F0463CD7" modified="2012-09-05" version="1">MSVSNVQKQRRSSIDPSLLQPMHRQLNMLSFESLPGPKFNLLFIGSGNINFGTDEGPWNHSKRAEMKWGTRLNVVGIVDPNSARADLELGKKRASFVAPAYSDTKWFPNVDAAKEGLTADEQPHAIIVGAPPQFRGGLAPPANLELALLEAFPETALFLEKPVTTGDAEDAKEVGKRIAAKGNVVSVGYMLRYSRAVQTMIKIIEEKDLTVMCTSARYICAYEKIAKEDWWDKARSCGPIVEQATHFCDLSRYFGGDVALDSVQAHSVEWNEEPGKLSKMPIEESKIPAEQRIPRFTTSSWKYSNGAVGSLVHGVALQDTDYYTELTVFADGYQLRLVDPYNNPTLYIRAPGSDAEVMQTFANDDPFFSELSNFGDLIERDSEHNKEKPLNTTVLSSYEDAVQTYQLSWAIRLSSEKGRKFPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGF1</accession>
    <name>I4YGF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_31681</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957079.1">
        <property type="nucleotide sequence ID" value="XM_006957017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGF1"/>
    <dbReference type="FunCoup" id="I4YGF1">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGF1"/>
    <dbReference type="GeneID" id="18471352"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31681"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003662_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGF1"/>
    <dbReference type="OMA" id="WEIPELE"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000033">
        <property type="entry name" value="Sulfite reductase (NADPH) flavoprotein alpha-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="611"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="999" mass="109707" checksum="A3FFAB32BC68CEEB" modified="2012-09-05" version="1">MPGSLNPPISSEGPSAIAQPISQQRDKFEKMPSIVDSGIGTPVSSEQSLSPQNSNKAGQSILKSALNAVEYNVSANSNSIFLYDSARYDGFGQDLSDDRVQLMQDRPGSGAAVSGYSRASQVATISVLINSQSLKNFIPTLKTYKEKSKLVLQVNTYERDSELNLKSGFTSILDAANQLENYTILLSATAQDIVNNSQLAYEIPGNVIHAFDGIYAAREKSALDQVKPPSTAVTFHSASPVTKALVVPASDISNALLSSLDSSYGLVVIHKLRPLSMKALSDSIPSSIENLLVYNEEKAQGVLLNDVVSAVFNAQRKIKVNAFSDITPFLSSQEATSKSCVFVEQPDQVSADLVGSLFSQNKQLSTKIQTAYDHFIGQTGLALSHIKIGKEVQESALTLPTESSVDFLNVNISSLKATNVFEYVKKGGIVLLDGPLQSPEEVPAKLPYADKKTIIEKGIRVWAVDSAAISEEHQSVATLIAFLLLFTSSVPRLPESIKSLVRAFLPDVTNLDSIIENTEESLYEAIVDESSWLALQPGKEIKPDNRLVGISFNGLSQTAVGTKEEQLNDKVKAIKGSWVEPAWQLLFNESFTTGEDVYERPLATLKPSLPEDTYLVTVKETRRLTPDDYDRNVFHISFDTNGTDLKYEIGEALGVYGHNDINEVKDFLSWYGLPENGVINVQHDNGKVETRSVLQVFQQDIDIFGKPPKSFLASLEEYATSREEQRALRFISSAEGSSTFKKLSEIDTLTYADVLRKFPTAKPPVEELIHLIGEIHPRHYSIASANAVVGNQVDLLIVTVEWATPSGSPRYGQCTRYLAGLEVGTKVAVSIKPSVMKLPERDDAPIIMAGLGTGAAPFRAFIQYRAWQREQGIDVGPLVYYFGSRYRSAEYLYGEELEAYLSAGVLTHMGLAFSRDGKGKVYIQHKMMEDKKILHKMLSRKSEGGDEGSFFLCGPTWPVPDVYEALCGSYIEAGGKTREDAENSIEDMKEDERYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGI9</accession>
    <name>I4YGI9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_36411</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957114.1">
        <property type="nucleotide sequence ID" value="XM_006957052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGI9"/>
    <dbReference type="FunCoup" id="I4YGI9">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGI9"/>
    <dbReference type="GeneID" id="18471961"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36411"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="InParanoid" id="I4YGI9"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="627" mass="70825" checksum="2572C9BB6B97EC91" modified="2012-09-05" version="1">MPTISVDKAELFKRLGREYTTKEFDELCFEFGIELDEDTTEEVLELQKQGQQTEAPQLKIEIPANRYDLLCIEGIARALNVFLGRADPPAYKPADTQNRRQLKITGETKDVRPYAAAAILRGVKFTEESYASFIDLQDKLHNNLCRKRQFVAIGTHDYDTVASDGPFTYEGRKPENIHFVPLNKDKEVDGNGVMELYSQDKHIGKFLHLIDKSPVYPTIYDSNGTLLSLPPLINGDHSKIKISTTNVFIECTATDATKLDMVLDIMCAMFSEYTEKPFEIEQVEVINPDNSKRLTPVLDKRLMKARSTYINSCTGLSSSAADLTKLLTKMGLPSKPSGETEYDLLVEIPITRPDILHECDIMEDAAIAFGFNKLPRTFPTAYTVAAPLPINKLSDIIRKETAMAGWTEVLPLILCSRDENCQYLNKDESELKKAVHLENPKTLEYQVVRTSLLPGLLKTIRENKHHALPIKVFETSDIAFVDTSLERKSKNQRRVAAIYNDKKGSFEVAHGLLDRLLNMLGIEFLPSTTRRGAEKGYYIVESDDKTYFPGRAASIVYRPPPTHKEPESTFDNLKSKLTEALPDGLKDLVESRDRVIGTLGILHPEVLEKFEIKNPCSAFEFNLEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGJ4</accession>
    <name>I4YGJ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957119.1">
        <property type="nucleotide sequence ID" value="XM_006957057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGJ4"/>
    <dbReference type="FunCoup" id="I4YGJ4">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGJ4"/>
    <dbReference type="GeneID" id="18473547"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59770"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGJ4"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="615" mass="67684" checksum="719D929B4663C04A" modified="2012-09-05" version="1">MPMLQDPSTKYKKFTPTIKLDDRTWPSKTLEKAPIWLSTDLRDGNQSLANPMSIEAKTRFWKMLVKIGVKQIEAAFPAASDTDFNFVRSVIETPGLTPDDVWVQVLTPARADLIKRSFESIAGAKRAVIHMYNATSPLFRDVVFRNSREETIKLAREHSELVRSLADEYSSKYGTIFAFEYSPETFTQTETEFAVEICQVVKSIWKPTAEVPIIFNLPATVEVGTPNTYADQIEYFCRHIGEREKVHVSLHPHNDRGSGVAAAELGQLAGADRVEGCVFGNGERTGNVDLVTLAMNLYSQGINPGLQFNDMLSVIDTVTQCTGLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEAQQKRKENGDHIWSMPYLPIDPADIGSSYEAVIRVNSQSGKGGIAYLIKQILGMDLPRRMQISFYQVIQQFSDATGTEISVDDIITTFKKQYYLEEFSTKGRLALRNFTLEDARAGPGEKTPSGIEENSRTFKGRIAVDGEPRVVEGAGNGAITALLDGLKEQFGAKLNVKSYEEHAIGKGSYVQAASYVNLTDQSEREYWGVGIDPDAAASGLKAVLSAASQACQDDVFPEVKPLATTDAIKNAAAGLVENVKQTVNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGS1</accession>
    <name>I4YGS1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956559.1">
        <property type="nucleotide sequence ID" value="XM_006956497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGS1"/>
    <dbReference type="FunCoup" id="I4YGS1">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGS1"/>
    <dbReference type="GeneID" id="18473371"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59472"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGS1"/>
    <dbReference type="OMA" id="YENGQHC"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697692" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="400"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="518" mass="58013" checksum="B9C798F53BECEB8B" modified="2012-09-05" version="1">MTLPRLVGILIALSLVGSVECIKGVDPSIEHLYKPIDGRFKCINSDVSIPYSALNDDYCDCPDGTDEPGTSACSSYHHTPQFYCHNEGFFPDKIHLSKVNDGICEEECCDGTDEPAGICPDTCKQRGKQYKVELEHSERIRDKALITKSKYIDSAKKELNRLSSVQQDKTRAIIKAGERELAAKAEVDRLEALSKDALSAKLASPLYKHLLDARSALDDLKKENEAVEADLSHLLDILESLKNSYNPNYQDMGVLAAVKDYNAYIDTRKKRSASNELLSKLQNEDLVNLIVSLDQSSGDKKDDIDSMLFNIEAYLPPTMVDNYRAFKETFVGWLVKFSIIPEPSTQGNASYIQNARKEHKKANDALQKARNGLAKTDAEVAELKSGIRWGPQGEWNALNKECVSQNIAEYTYELCFFDKVTQRQQGRKSGGTSLGKFHSWNEDAGPGSEDFYNLQVYTKGQRCWNGPERSADVEIVCGEYNALIEVEELEKCAYKLLASSPAACHENTRRVHIRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGY3</accession>
    <name>I4YGY3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956617.1">
        <property type="nucleotide sequence ID" value="XM_006956555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGY3"/>
    <dbReference type="STRING" id="671144.I4YGY3"/>
    <dbReference type="GeneID" id="18471291"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31375"/>
    <dbReference type="HOGENOM" id="CLU_1289837_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGY3"/>
    <dbReference type="OMA" id="NHPQPNY"/>
    <dbReference type="OrthoDB" id="2593559at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="73"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="22197" checksum="336567249C2C46F5" modified="2012-09-05" version="1">MSTTSNIFQPPEPYSYTSAMYSAVPAPPAGLHPQQAHLRQTHRMPIRGSFHIATGAAFHTAENDTEAALQGPSARFETNDGYVDVRVWVSGGSGIATVEASSKSGRVKVEVVDCPSRLPLRLQAKSQKGPVEVLLPPCFSGLLIADAQQINLSEGAQKRATQVVGFDNRFLIAGLDGSTRGGSEVKIDAHNADAKIAFARENNQLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH89</accession>
    <name>I4YH89_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956716.1">
        <property type="nucleotide sequence ID" value="XM_006956654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH89"/>
    <dbReference type="FunCoup" id="I4YH89">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH89"/>
    <dbReference type="GeneID" id="18471304"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31449"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="InParanoid" id="I4YH89"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="477" mass="52767" checksum="1995C3FE5FE103E6" modified="2012-09-05" version="1">MLQRIANSRLGMISRQLSTSRTSSISTKSLVNESVKDSPITFTERVGLKTFSLNRPKALNALNQEMMILIKNRIKEWDSNPSTGVILSSGVGKAYCAGGDVKSIALNPNKDDALNILKDEFELDHQLAVLTKPYVALMDGYTMGGGAGISLPAPIRVSTDNTVFAFPETRLGYAPDVGASYYLSRLDGQLGAYLSLTGNNVSGSDLYHLGLSTHHVSPSLFPALVGRLSDLSSSPVTGSDVNSVIDEFTTQPLPKLSETLMGAHRQAIDDAFGQSSVEEIIQVLENFKENRPEVGKWAAETLETLYDRPPTSLKVALEAVRRGVKMHNVAQALQQELTFANQFIYNSDDFRAGVTAVLVNKTTEVPQWQPNNLKDIRKNDVIGSYFTTTENTSDKLEIRNEKKPLYDFFHFALPTEREIEDYIRGSHPASGNNAVRRNEALTFFKTQDNAKYGVTEKVNEVIDRCTIEEKGGYLKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHD0</accession>
    <name>I4YHD0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_43451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956753.1">
        <property type="nucleotide sequence ID" value="XM_006956691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHD0"/>
    <dbReference type="FunCoup" id="I4YHD0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHD0"/>
    <dbReference type="GeneID" id="18472291"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43451"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHD0"/>
    <dbReference type="OMA" id="RIWYSVG"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="927" mass="105602" checksum="814E4641728B1855" modified="2012-09-05" version="1">MGKTPDGTLFNVPPTSDVISSLFHPKYPKTHVDIVTLTILGLHVFGFFVLPFEVSQKLYLGLFMFWRLAYNVGLGIVLSKQSKHHFIVNWVKKNGFLDANKRPKVRTWVENQIKTKMGPEYKFDECPVEFNTWIFFRHAVDIILLSDFVAYCCFAWSHCRLPDGHGVFWHALRWFAGWTMILFNLWVKMDAHRVIHDYAWYWGDVFFQQIQSLKFDGVFELAPHPMYSIGYAGFYGLSLVVGSYTVLFGSLLAHALQFGFLLAFENPHIERTYGQKKPLAARVPLPLPEDVPDEDSHSNDELEDIAAKRKSSSASINRVEGYPNAPSNLHDLEHRYFSRDLIIFKNFDIFRSNDFSTALLVFYAIVASFLPNFKPTTSLVLHVLHAAAWRIFHSFALGCLLKAQSENKYLVKHYLKYYAHVHADDAKRSAFDAWKRVYNLSLVMVYVSFVGLAYKTYDLPVQWTVGTELLKHTVGALLIALQVWCALESHEVLGNFGWFFGNFFLEDYPSRLEYTGIYRYVNDPERSMGGAALFGIALISGSPITFAVAVFSYILHWWFLSFVENPHTQKLYGKAVRKTGGAARTIKNAVKSGRRRSSLFNAATENKIDKVAKDVQGHVNKVYDETVDVVEEFIKNAKPSVNKVVQDTRVLLHQSREKLVITRVDKDLSAYDLSKYSINLKPSISPRQPMSYHLGESIQVEWTAPVNHSRKDWIGVYRVGANKDHLVTRISSQGKWQAIHEEEFDGARPVPERPHVENASGSSSQDLQKGIVTFRSNSLPWNVGRYEFRYHHAGKHNVMASCGPIEIFVDKPTDPDGFEPVRNNLSRSVAFALDCEPTLVPSASWHHLPEDTPLDEARKMQDEDDMVIMNDTQAKRIALAIKEAHDVDFTPAVIIADANLSRLTQRVLDTRRVLGIVEHRTPAVTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF2</accession>
    <name>I4YHF2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956774.1">
        <property type="nucleotide sequence ID" value="XM_006956712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF2"/>
    <dbReference type="STRING" id="671144.I4YHF2"/>
    <dbReference type="GeneID" id="18473441"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59589"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_797417_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHF2"/>
    <dbReference type="OMA" id="MNADIYD"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39672" checksum="E14588423EE54E7E" modified="2012-09-05" version="1">MLMNADLYDSYIDSQGVYNMENALYSAISLIERCTTIEESRIGYLYLTLHAPRVGEWNVMLVNTLKKDLESESDARILLAVTFLIHKPFMEVIPAVNLTLLQLLSHNRRFVRLRVANAISQLIAISDDGGLFDSDALMKFVKEDTSECLQNIKLDLMDKVNKYQNNDSTFHDVDIQQLETLIEGSEDVILRRPVYVLKILRNISVNATTLGNTSISNILVKLLRQVRETSSPYKHAIGLEILKHAREIPTEVRSYIENLINNKTANTPNYRYAILAQLLVIPGDVANKILGEKESLYVMDTLENQDVTLRKKALQLLGHIDMNTLKQYHQMLLQVGSQLASECEEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF3</accession>
    <name>I4YHF3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_50337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956775.1">
        <property type="nucleotide sequence ID" value="XM_006956713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF3"/>
    <dbReference type="FunCoup" id="I4YHF3">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHF3"/>
    <dbReference type="GeneID" id="18472521"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50337"/>
    <dbReference type="eggNOG" id="KOG4473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHF3"/>
    <dbReference type="OMA" id="MNFHHTL"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="325" mass="34594" checksum="9444A8A400E027BA" modified="2012-09-05" version="1">MVCQNPENCCGGSCLSNKLPKPTSSDEETYAESSSPGKCDKHARGVCCRELKGDDERNLIDPDFVKDAIIGLSDGLAVPPALVAGLAGLGDSKLVILGGLSEIVAGAISMGLGGYLAAEAEMNHFKYLRRVTRQRVARSCAGEMEREVHDVLGSVGLSEEISNEVTTSLTKLEPPAPAQAPSSFLRSLIEKFAKKPTQLHTPEEGDLRWSDEFGLTAFLLKYGEGVEEVPTSKLIKSAITVGMGYAIGGMWPLLPFFFISEAHEAFKISILVTSFVLFTFGILKQYYTGGTGGFGGYLYGGISMLVVGALAAGSAYGLVKAFDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHK6</accession>
    <name>I4YHK6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_15406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956507.1">
        <property type="nucleotide sequence ID" value="XM_006956445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHK6"/>
    <dbReference type="STRING" id="671144.I4YHK6"/>
    <dbReference type="GeneID" id="18470662"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15406"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHK6"/>
    <dbReference type="OMA" id="VYATLIW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="201" mass="22578" checksum="C33BF16FBE13555E" modified="2012-09-05" version="1">MTSLTHLDLTYVLYTGDSHLSFLLALVTLLPFAILSGYVTLVYFNRDAVILNAFAGQLANEALNWLLKRIFKQPRPFIGTGYGMPSSHAQFVAYTAIFITFHQIQRNGYPGMESKLAFLVAIMIAYSRHHLSYHTTTQIIVGFVIGMVFGAVYFTLTELSCTLRFSKKTLIGKICWLLRQTRSLIVNNLSLNDQTLAARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHM1</accession>
    <name>I4YHM1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_43603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956834.1">
        <property type="nucleotide sequence ID" value="XM_006956772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHM1"/>
    <dbReference type="FunCoup" id="I4YHM1">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHM1"/>
    <dbReference type="GeneID" id="18472298"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43603"/>
    <dbReference type="eggNOG" id="ENOG502QRMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006124_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHM1"/>
    <dbReference type="OMA" id="WSQVMYW"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="267"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="816" mass="91542" checksum="01CD04F234C523AC" modified="2012-09-05" version="1">MLECVLGPLGRRWVDVDLNDNEGSPMIVLAAASVWLDGVSLLIKTGADVNASDSQSWTALHWATINSQSQPDISSQIIGLLLQNGASPLVKSNKGRTAKDIAPASNDIVELLEVAQEQAFITQSNSDLFSLSQASATPSQSGRSKQRAKDKKAAYENSVLRNAAKELDFECSLILKEGELDEAAEEDGEELTDSLSKTFDWNTCLPHQMLIINSDQVKQSIDALLSLSPHPKPLSYESSPASALFLWQRYAFYVGDPSGELSSIIFDHAVENIEQTLFNNPENLPLLAFWLHNVTLWLYFINSDASMSEECKDMQDILSDFTNEIYVFIVRLVERKMDRVIEPFILDFNSMPEFDDIRFDGEWRIMRALTKRKGSVRSPNKKPPGHRRNGGGSLSSSIFGKTGGSTSSFSDIFSSSNADNNIETLKSPSMNSFDDEMRNRPLASDGGIAPSASLASLSNTNDGEDIISEKFSKVNIDDVNNNSPKKVTQLLNSTLIVLELYNVNEALIIQIFSQIFYWTACEIFNRMITNKKYYSRSRASMIRLNLSAIEDWVNINKLPSSIFTYHFATVSQMLRWLGCLSAMSDFSALISTLQTLRQLNPKQLFKLQKEYRHEAGPTIESRMSSECVEYLEQFVNAWDSRKKTSETREDSSEVPQKTQNHIDNIYPENQSSSSAYDTSIGLGLGLQPLPSNSNVLKDVYVPPPLPENFNEQVDSRYMLPFELPTNHEHLQWRRKHSFTYRHISAFDTPKISSPGLLSDDDHLSILNSRPPSRASSCHSTGVYGQFTVTPDVPEDILEFVDRFVHESLDTLKNERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHM2</accession>
    <name>I4YHM2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956835.1">
        <property type="nucleotide sequence ID" value="XM_006956773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHM2"/>
    <dbReference type="GeneID" id="18473461"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59624"/>
    <dbReference type="HOGENOM" id="CLU_2962658_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHM2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="59" mass="7323" checksum="539AF54D7C85232D" modified="2012-09-05" version="1">MVFTLKGIFYQHIDWSPKYFYDPNKKVQIRWYLKCQREFTWTESILLLAYTSNHLMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP1</accession>
    <name>I4YHP1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956161.1">
        <property type="nucleotide sequence ID" value="XM_006956099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP1"/>
    <dbReference type="GeneID" id="18474713"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62153"/>
    <dbReference type="HOGENOM" id="CLU_1129823_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHP1"/>
    <dbReference type="OMA" id="EMNRSER"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="2">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="28736" checksum="C2BFC4E4BD8EC9AD" modified="2012-09-05" version="1">MFIKALAKFTALCASNSTKVIALANLAPFGSLFGSSPELLKRTLFTTATQLRERERDPALQPPAKPKSPYLRFMHHLIQKEKRGKPLLKIDTIKFGQQVAAPSWESLFESDKKPFEQAYQHDYKLYKPKERDWWMSKTHSDISLINEERRLYGMKPLSFPKEYMKEIRENERQARQAEKSLKPKGIANSRIRFMKEVIPSLSRELGNSQEAMKAASKQWNELTDDEKEPYQQAYLKERVEKELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHZ8</accession>
    <name>I4YHZ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_42757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956263.1">
        <property type="nucleotide sequence ID" value="XM_006956201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHZ8"/>
    <dbReference type="STRING" id="671144.I4YHZ8"/>
    <dbReference type="GeneID" id="18472264"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42757"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="InParanoid" id="I4YHZ8"/>
    <dbReference type="OMA" id="KPASCEI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698025" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="15016" checksum="FBE850854153EE52" modified="2012-09-05" version="1">MVKISALVLGVIGAVAATTKTPPSSLQIGIKEKADPCVATAQNGDNLTMHYSGYLFDDGSQFDSSRNPGRQPFTFKLGAGQVISGWEKGVLGMCVGERRKVTIPPSLGYGSRAIGPIPAESTLVFDIELLDGASGPGKAVHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI01</accession>
    <name>I4YI01_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956265.1">
        <property type="nucleotide sequence ID" value="XM_006956203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI01"/>
    <dbReference type="GeneID" id="18474730"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62262"/>
    <dbReference type="HOGENOM" id="CLU_3108205_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI01"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="6078" checksum="2FA5A1C7CDD5CD61" modified="2012-09-05" version="1">MTSERQNKDKVTKYNDPCADAAKKSFECLEDNYYQKDNCREAFENYRSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI90</accession>
    <name>I4YI90_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_35285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956348.1">
        <property type="nucleotide sequence ID" value="XM_006956286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI90"/>
    <dbReference type="FunCoup" id="I4YI90">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI90"/>
    <dbReference type="GeneID" id="18471909"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35285"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="InParanoid" id="I4YI90"/>
    <dbReference type="OMA" id="MYVLDKD"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="65" mass="7551" checksum="8C1D1BD4AE77A035" modified="2012-09-05" version="1">MHLMFSSDEQGKRVYSLKKVTDNGVITKSAHPARFSPDDKYSRQRVTIKKRFGILPTQLPRNRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE5</accession>
    <name>I4YIE5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956402.1">
        <property type="nucleotide sequence ID" value="XM_006956340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE5"/>
    <dbReference type="FunCoup" id="I4YIE5">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIE5"/>
    <dbReference type="GeneID" id="18473319"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59371"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIE5"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="670"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="812"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="951" mass="107037" checksum="E751C83D52DC1343" modified="2012-09-05" version="1">MEVPSYTLINYEITEIPTTQELRQGLEKGSDQIKLDTLKKIILLTLNGQSQPDLLMPIIQSILPNKNKHLKKLLHFYWEICPKYDEQNKLKQEMILVCNAIRNDLQHPNEFIRGSTLRFLQKITDYELLEPLLPTVRTCLEHRHSYVRKNAVFAIWSIYNKFEYLVPDAAELLQAFLVAESDNNCKRNAFVALANISTPIALEYLENFRDNLLSFDELLQLSLIELIRNDKDINANRALYLNFISQLLESSHYSVKYDAAITLTVLTNNSLAVKSAAAAFINIILNVSDNNVKLIVLARLSEMLSTNPNLLDTLVLDILNVLSAPDLQVKKKVIKIILEMINSRNVDQIVDYLKNELLKTTSSQDFERNVEYRQLLIQSIHTISIKYSQVASSVVDTLMRFLGDSNNPSAVDVISFVRQVVEKFPSLRQTIIKRLFETFSDVKSGKVFRGALWIIGEYCEQTDDIKMAFEKVRLVIGSIPILAAEQKAYDEQDYQNTNEENGQEQLITTTKVLADGTYATETKVSSAEDASRLAAVKAASKPPLRGLILNGDFYTASVLASTLTKLVMRLSTNQNLEANELNSIKAEAMLIMTSIIRVGQSKFVSTQIDEDSAERILSCVQALADEAASNSFKDIFLNDTKAAYSKMIHIEEEKVKEKNIKDSKVVKVQPDDLIAFRQFKKKTVDLDTKEFELDLTRATGADELKDDFMSKLQRIVQLTGFSDTIYAEAYVNIHQFDIILDVLIVNQTGNTMQNLNIEFATLGDLKLVERPSTLTLGPHAFHNVKATVKVSSTETGVIFGNIGYDGPGAAESTNIVLNDIHVDIMDYIKPAYCNEAQFRSMWSEFEWENKVHVNTSISDLRLYLKHIMKSTNMSCLTPEASMSGECGFLSANMYARSVFGEDALANISLEKNEEGVNDGVIQGHVRIRSKTQGIALSLGDKISLAQKSPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ7</accession>
    <name>I4YIJ7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956452.1">
        <property type="nucleotide sequence ID" value="XM_006956390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ7"/>
    <dbReference type="STRING" id="671144.I4YIJ7"/>
    <dbReference type="GeneID" id="18475248"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67401"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_1_2_1"/>
    <dbReference type="InParanoid" id="I4YIJ7"/>
    <dbReference type="OMA" id="GPYWPAE"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="271" mass="30288" checksum="1385606BB3F8CBD0" modified="2012-09-05" version="1">MSQFAAKAFSSSNYAAARPRYTEDLLNKIFEYHKSGSALSVDLGCGPGTITSYLSERSNHVLGVDPSSNMLNEAKKQLDGLKNVELHQGLANELPSLLSEPADLIVSAQAAHWFHSPPNNTSNCGLWKDIGASLRSGGSLVYLVYGDIEVLNYPNLSAFQRVKDILQPYWQQPGRRFLVNLLRDVEFPEWGVNTQRQFFDKETGYVLKNSTSISAFSEYISTWSSYSKYLEQSNANTQLIEQLNKDIKEEVGGDKPLEIAFPVALFMCQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM2</accession>
    <name>I4YIM2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_53486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956477.1">
        <property type="nucleotide sequence ID" value="XM_006956415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM2"/>
    <dbReference type="GeneID" id="18472616"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53486"/>
    <dbReference type="HOGENOM" id="CLU_1705625_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIM2"/>
    <dbReference type="OMA" id="WYEDYSI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="18825" checksum="90A7004DD7468223" modified="2012-09-05" version="1">MRLKLKTSQTRLADILKNTTLREQFIDYLQNKEKSIENLDFVLWYEDYNRRFPKTPLDQQRVEVDNILQTYFDGKSLSELNLDEDVKLTTLKNVKLSFDNSTTIDPLTFKHAYDICFHLIESSSIPTFTSLHRKRPSLRNFFNLRRSSSGQSHSSRTSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT9</accession>
    <name>I4YIT9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_58990</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955725.1">
        <property type="nucleotide sequence ID" value="XM_006955663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT9"/>
    <dbReference type="FunCoup" id="I4YIT9">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIT9"/>
    <dbReference type="GeneID" id="18473109"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58990"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_5_0_1"/>
    <dbReference type="InParanoid" id="I4YIT9"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="23792" checksum="EFD8B577BB085435" modified="2012-09-05" version="1">MPKPTKSNLREFKDHQGHFSLVRNFHLADLFTIMNGVCGVSSIFSSAHYLLDNNNKEAIYLALLLPACGFIFDALDGKVARWRKSSSMLGQELDSLADLISFGVAPAFLAFTIGMRSTVDMIMLTGFVCSGLARLARFNATVANLPKDAGGKSKYFEGLPIPSSLALVSLMAYLVKTDRIHQDIPFGVYFNSIHPISLIFGLWAAAMVSKTLRVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIW9</accession>
    <name>I4YIW9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_55832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955752.1">
        <property type="nucleotide sequence ID" value="XM_006955690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIW9"/>
    <dbReference type="STRING" id="671144.I4YIW9"/>
    <dbReference type="GeneID" id="18472745"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55832"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013363_2_0_1"/>
    <dbReference type="InParanoid" id="I4YIW9"/>
    <dbReference type="OMA" id="ACENTIF"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="1">
        <location>
            <begin position="210"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="62358" checksum="212AF2F8661617CE" modified="2012-09-05" version="1">MNVYEELRNRITNKSPWDTEVTFLRQSLRKRLQSDLLMGSDNDVSANLHNIWHETTHNLIIEYRRRLKNIDSSSKPNKVWLERRRVLQNFIDFMKKDEVFYRSIIARTITLFGLDEYTHLLAQIEPNKNVVNSDDTSSDDGRADVSLDYSNQVAEEGTFDKNTRVYIIYRCLIFLGDIARYKELYNQEGGRPKAGVQYEQNSRHRQYANALLCYELAQSVMPSEGMHFNSLATLASYRDDFIAVVYNYYRGLTLSSPQHSKWQQLARNNLKQVLTKVLDEENNVNDDLRIFTVQLLKIHGMLFLNRTDYQTVSKLINSSLRQFQKLLDSGTLRNDVILKIVTINISLHYHLRVYRDIESIPNKMSLENRRNTAHKYLIRVVTILMKHVRASLAEVELEESAQDDIKLASLLTTSMRRCLPTLRLFMHWLTSNIDHHNKIKASSKSNSIPQFWEEFEQFKQALSSSFENLKIDRCEYSLEEDEEFQQFNPIKRCPMRGMSKMESNELRRQRHPNDEQLERGIIIIRLGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIZ8</accession>
    <name>I4YIZ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955779.1">
        <property type="nucleotide sequence ID" value="XM_006955717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIZ8"/>
    <dbReference type="FunCoup" id="I4YIZ8">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIZ8"/>
    <dbReference type="GeneID" id="18473129"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59019"/>
    <dbReference type="eggNOG" id="KOG0183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="InParanoid" id="I4YIZ8"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="259" mass="29033" checksum="3435E5BDEBE1554C" modified="2012-09-05" version="1">MSRSYDRALTVFSPDGHLFQVEYALEAVRKGTCAVGLAGKDIVILGVEKKSTLQLQDPRSIKKVVNLDDHVSLAFSGLTADGRILVDKARVECQSHRLTVEDPVTVEYITRHIAQIQQRYTQSGGVRPFGLSCLLIGYDPYDNIPKLYMTEPSGIYTAWKSIAIGKSSKTVREFLEKNYQDDLNDDDAIKLTIKSLLEVVQTGAKNIEISIMKKGEKVKQLDNQTIEDIVNTIEQENKALDEQRKSRLQQQLDAQSAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC6</accession>
    <name>I4YJC6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nramp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_30820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955895.1">
        <property type="nucleotide sequence ID" value="XM_006955833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC6"/>
    <dbReference type="FunCoup" id="I4YJC6">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJC6"/>
    <dbReference type="GeneID" id="18471192"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30820"/>
    <dbReference type="eggNOG" id="KOG1291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_4_2_1"/>
    <dbReference type="InParanoid" id="I4YJC6"/>
    <dbReference type="OMA" id="AQNCKKH"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="596" mass="65498" checksum="7663D99FF1AA947A" modified="2012-09-05" version="1">MDSDVQRPFLSREDTDDAEEHINNRQSFKYVRPVERRSFLKTVKQNITDHFKFVGAGIIAAVSYFDPGNWGTDLAAGSQYGYSLLGVVLLASLGAILYQILSCRLGIVTGLDLAQHIRLQLHNREKNPMIWRWMVLYPLYVLAEFSLVATDLSELLGSAIALNLIFPFMPLWVGVSLTALDVLIILAMYNPSGSSRSMHIFEGIIGVMTIAVFASFAVLVIKVHPEWSEVMRGFLPNKLAFEPGATYISIGIIGATIMPHSMFLGSKLATADRLASASSVNSSRTSSNEDRFSLSNIEETSRNPLEYVAKAMKQDPDYEPSPRIGDADVYEGGPGRLPSILKHLKHGSWDIALSLLTIAVPVNAAILIVASATFFNNPNRDSEGVADLFDAHDLILKYIGKPFAFIFAFALLCAGQSASITATQASQAVSEGFINWKSPPILRRLITRLLGILPSLIIAVIAGRSGVDQLLNASQVVLSIMLPFAIGPLIYLSGREDVMRVWNPTDEGQSTSTTNLLDPSRLGPSHAHRRRQSENVTIDGGYQQFQLADQLQLNTTGQWVDLRPSKYILIISWIIFVGLCLSNGFVVVQVCRGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL2</accession>
    <name>I4YJL2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_42318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955978.1">
        <property type="nucleotide sequence ID" value="XM_006955916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL2"/>
    <dbReference type="FunCoup" id="I4YJL2">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJL2"/>
    <dbReference type="GeneID" id="18472246"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42318"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJL2"/>
    <dbReference type="OMA" id="DHHGNVG"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="111"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="216" mass="24195" checksum="1427B3832E533AA1" modified="2012-09-05" version="1">MFFIRQLPTQARQFTASSLRLKHTLPPLPYAYNALEPYINEDIMTTHHSKHHATYVNGLNAAEESYVKAQSANDVKSLIALQPALKFNGGGHINHTLFWKNLTPESGKTKPTGALADQINKDFGSFDTLKTKLNTATAGIQGSGWGWLGYNKEAKRLEIATTANQDPLTHLVPLLGIDIWEHAFYLQYKNVKPDYLNAIWNVMNLEEAGQRFDAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJQ6</accession>
    <name>I4YJQ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_34808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956017.1">
        <property type="nucleotide sequence ID" value="XM_006955955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJQ6"/>
    <dbReference type="GeneID" id="18471884"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34808"/>
    <dbReference type="eggNOG" id="ENOG502QU4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033925_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJQ6"/>
    <dbReference type="OMA" id="LWTRGNW"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF82">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53583" checksum="B8C786786F1B2445" modified="2012-09-05" version="1">MSSHDEADLSGDVDKLTSNTSSAELPNTSDETAINQAKTGSQVGSFFIGLVIILIASIMNSIGLNIVQKDHLSNQSLPKDQQKRDLRRPLWFLGMSLYILSQLLGSTLALQYMRAEFVAPLGSTNLIFNFLIANYMLNIPITKRDIQGTLLIVVGVIGIVGFGSVNDGISDFLDINVLIELWGRLAWLLWFFILLISTFSIYVIGLDLEKISRRRADESGYATPTTDQQPTNSRIKVFLSKFTFIFTAIRAKMFKTLENIVGNIDDPSLKKVVGLVWAIEGGIMASECLILAKATVKLVSTQFSHNEAANQFAHPLFILTILLLATTAIGQIICLNKALALFDTTMVVPIFYGLYTSIGFINTLIFMNQLMAFRAWVLWCIGFSTILLLSGVYLLSAKKPSQEEINEEQTNDEIPLNVRSSNRDVEASHDNENKDDYDDDDDVVWDIGEASDEDNHDEQTDVRKPLRKQQPENETEPNPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJS4</accession>
    <name>I4YJS4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956034.1">
        <property type="nucleotide sequence ID" value="XM_006955972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJS4"/>
    <dbReference type="FunCoup" id="I4YJS4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJS4"/>
    <dbReference type="GeneID" id="18473197"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59148"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041474_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJS4"/>
    <dbReference type="OMA" id="NCTECAR"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="355" mass="38612" checksum="AAD7CD45BE8D6A4D" modified="2012-09-05" version="1">MEFDGNWNALSEQMGNLNNLLASSAGTTSHNSPCTSYLDDKEMSTYGSFPMSSLNDLDDGLKVVNCTECLRPVQKSALEEHSISCSIMKQINQSQPKSSNNRKSKLKREEASSTPTPVPSSADLTANPSKKRRLSDASQHSQTSSNSPQKKSRKLDAESLKIKSKSSSSTGSTSKARKEDGPVDLDSQCGVLNAKGVQCSRSLTCKTHSMGAKRAVIGRSKPYDVLTYEFEVKRKPELADKPVPKAVTQFEADRAAAKKRTTPVQTPTPTPPVKPKVLPKVPAIEEKAIGVTSWESQLPAPDEELLPTTGLELDIEISKIRAITAAHTPKALGGPTNRMSGLIRKRTMMRRCLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJX7</accession>
    <name>I4YJX7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DsRNA-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_13165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955649.1">
        <property type="nucleotide sequence ID" value="XM_006955587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJX7"/>
    <dbReference type="STRING" id="671144.I4YJX7"/>
    <dbReference type="GeneID" id="18470610"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13165"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100405_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJX7"/>
    <dbReference type="OMA" id="NEESRRY"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="137" mass="15124" checksum="DBAC4AECC89CDDF5" modified="2012-09-05" version="1" fragment="single">LTKRLAPECISQRPGGGNSKVCYIEGHQAIALTNSIFGYDGWSSQIMDTKIVYIEQSPNHKWHCTAQALARVTVLSTGAFHEDVGFGDMANSPTRGAAIDKCMKEAVTDAVKRCLRYFGNSTGNCLYDNNYTREIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJZ3</accession>
    <name>I4YJZ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_14367</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955670.1">
        <property type="nucleotide sequence ID" value="XM_006955608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJZ3"/>
    <dbReference type="FunCoup" id="I4YJZ3">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJZ3"/>
    <dbReference type="GeneID" id="18470634"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14367"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJZ3"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="17">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="18">
        <location>
            <begin position="137"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM24285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="31758" checksum="C471BB650CA20543" modified="2012-09-05" version="1">MANSRFGYVRDFEEYEKLVPYSFTVVRIDGQSFHRFSDIHQFEKPNDKRALECMNSAAKFVLEEIQDVILAFGESDEFSFLLRPQTTLYDRRKAKILTKVVSAFTSAFVYNWGRYFSTPLAYPPGFDGRTVTYPHPKHVRDYFAWRQVDTHINNLYNTTFWAIVQQGGKTEREAHKILQGTVSAEKHDILFKEYGINYNTLDDLYKKGSILVRIPPPMPEIPADGSYKDKKKIEKIRKDGIDGTRGPIEILHLDIIKDTFWNDRPWLLSQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK05</accession>
    <name>I4YK05_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956109.1">
        <property type="nucleotide sequence ID" value="XM_006956047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK05"/>
    <dbReference type="STRING" id="671144.I4YK05"/>
    <dbReference type="GeneID" id="18475212"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67117"/>
    <dbReference type="eggNOG" id="KOG2288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070399_0_0_1"/>
    <dbReference type="InParanoid" id="I4YK05"/>
    <dbReference type="OMA" id="SIARWYI"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29514" checksum="C9D597D69D3323FD" modified="2012-09-05" version="1">MSFARSLSMSDDCETESEPPPYTPPIEIRHNYSDTLLTRLTHESQQSQNTLRLQRETTPISLTLIYQLLQLTSLLPALTGVLYLLIRTASPQRTLPNPSRIEYLASTPWAILTAVHSFQIISSMLHRWKHYYHPISVIIRLLSIQAASFPWIRVTLWVTSEPEKPLIAWIIVAYTTAISSTLARWYISNLSKSSKANQSRHLDINRLVTRTILPITTLSVLSLLFVLYDLYTTRLALTSNFGSNNNAIHISNLASLKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5B9</accession>
    <name>I4Y5B9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_70816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960783.1">
        <property type="nucleotide sequence ID" value="XM_006960721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5B9"/>
    <dbReference type="GeneID" id="18475790"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70816"/>
    <dbReference type="HOGENOM" id="CLU_1190673_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5B9"/>
    <dbReference type="OMA" id="KHGDWLA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698548" description="Protein BIG1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25821" checksum="F39CEA48F6A82633" modified="2012-09-05" version="1">MRLDLSIVAAGLLASTCQAGSPFFIASTEASSGIDRMRNPISSNDIKQLSKNDLCDLDTVVVIEQPTLQESDLQRFTSQFAFYESSYSISDALSQPSDVAQLISRTCKSKVHNYKENDSVSSDKKSVINVKGTAKTLDGLSESKRKEYINKLLHKLPLSTIQTRFPNHALIITSPAIGFNYFTTPLLSALFISFGILTPILIFAIKALLAISPTPKQSNTTLAQMPPSSLTEKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5S4</accession>
    <name>I4Y5S4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960592.1">
        <property type="nucleotide sequence ID" value="XM_006960530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5S4"/>
    <dbReference type="STRING" id="671144.I4Y5S4"/>
    <dbReference type="GeneID" id="18473064"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58784"/>
    <dbReference type="eggNOG" id="ENOG502S4QJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053753_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5S4"/>
    <dbReference type="OMA" id="WKEWKRG"/>
    <dbReference type="OrthoDB" id="5582002at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25900" checksum="332C7BB36F63A5D6" modified="2012-09-05" version="1">MGPEWQEDEIKDMSKSHRRKEANWDRKHNVKSWFRGQRKCFGITRKTAVFISFGVIIALILLLYFLIPRAPTFTFRSTPLLTDDPDSASFLTYPTTNFSYDGSVAISLDTTTSWIPIKIKNIDATVYDGETNNEVGTGGFKSTQSYSKSDNIHVNVPIHFAYQASDQNDQTWVNWHDACRYRFAGEGSSTTLSIKLKLDMKVEGLTKTSTVSQTSDNTVACPFTLPSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y625</accession>
    <name>I4Y625_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960567.1">
        <property type="nucleotide sequence ID" value="XM_006960505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y625"/>
    <dbReference type="FunCoup" id="I4Y625">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y625"/>
    <dbReference type="GeneID" id="18474561"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61490"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y625"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="163"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31420" checksum="D2368F3A9B72FFFB" modified="2012-09-05" version="1">MTRILKPRQLSELKNFIALDASWHMPNSDRNPEQEYLQKHLPKARRWNLDKIAAPHPNAFVGHMLPTPEIFAQACSNFGIERNSQILLYDTIGVFSAPRAAFTFRAMGHPHVAVLDGGLPAYEREGLPLESGEVAVEPTEYPVPTLQENYIKDHIDILNTIKGDNKATILDARPKPRFTGEAPEPRPGLSSGHMPGAFSLAFPQLLTQQGQFKSADEIKAVFENTLGRDQLESILAGRQNVITSCGSGMTAAIVGLALEIIGGHSAIYDESWTGYAQRGNSPIVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y692</accession>
    <name>I4Y692_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_49013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960516.1">
        <property type="nucleotide sequence ID" value="XM_006960454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y692"/>
    <dbReference type="STRING" id="671144.I4Y692"/>
    <dbReference type="GeneID" id="18472477"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49013"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303780_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y692"/>
    <dbReference type="OMA" id="TEWQPHD"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="300"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="929"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="980" mass="113200" checksum="E16039C8E5969D34" modified="2012-09-05" version="1" fragment="single">MSLKGLGWLEGLDKQRLFGRYPLPPSNPLQLPAFHSKLLDVAVCQPYTAILTPTKLIVVSLKPSPTTIYRVINEKPSDHTTGTLAWNNNTLVFNWSNTVYKVNLDDQITHSSRVYDRKIMSSHWIDSNLILLRSPTTFDLVEPASLEILESQPYDTSHLPNTPSSFQVLRKKCFFLTENHLSVAFLLNYKDRLGSLAKDGKYIEALQLAVAYFKGEGGHRLTTHLPDSTMERQPLVQPFLSSLLKSSTTYLEKTITAQSKEALRYLAKHMIEAAYLIDNLDWLFNEIFDIYQNNKLEYPFLVELEPLVRYGKLPVIPPNMSQLLLRLYDPKDHPGRYEELVLNLDATQLDLNGVIKSTKIHKLWKAFIYVHLTALGDFLTPTLELINSIRNDQQEGDKVTLFDYLGYTLSGLLYPSQKALESIDDDYSEEGLSFRGKTSIYQLLFNGKLHSDDINTSDNYSYPYVRFLLALDSRLFFAVLNRGFEEGYFNDEGTSRPLSRQTIVNLLLEMIYTQDLPIGTITQIEVFVSTNLSKYPQFLMLPSSTILQLIMGLSEMQDDSEGNQDISGASQNERELAVESLLSTFTPNSLNKILDQLIEVFERAKFYKILKSSYRTKKEWRNLIRITLEDIYDEGLFENLNQTFKWSRDDVELFDVFETFVDTLIRLDADELVMLVDKHSNDSDEVHTNIVQWCQEKRHIVEYLAAALRIRNGELSDPLKDIYITALATYKKEEVYGAIKAYDFNHELVDRLCVEGNIIDARLYHLNAEGLHKEAFDYLRHSTSESADEDTLKRAFKVGMKIAIDYAHNGSEEANNMWFIVLSSSMTAVRKYNWSNDILDEILNAVVLHTDLNKMTFSTLFRKLVDHFMVEPKGEDKPYDQLRSVLMCFMDSIRSRQEIFSVARRIMDRDAASIINEYSEKRRSGWSASEKYRNELDELRKYNEESRKLSEIAEELEQQGVDYREIFEIPPVKQRVVKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6F5</accession>
    <name>I4Y6F5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_22126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960345.1">
        <property type="nucleotide sequence ID" value="XM_006960283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6F5"/>
    <dbReference type="GeneID" id="18470913"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22126"/>
    <dbReference type="HOGENOM" id="CLU_2352438_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6F5"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="97" mass="10749" checksum="A585F88E48D435BD" modified="2012-09-05" version="1" fragment="single">LEAIFGSLSNEVAHLDTKMLLSEPGYFRTSFPNSTVFIDAGISIGDYEAISKPSEDMFKATHGNQPGDHKEGSKRIIKLLTGTGLVKDKEMLFERSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I0</accession>
    <name>I4Y6I0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_61394</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960370.1">
        <property type="nucleotide sequence ID" value="XM_006960308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I0"/>
    <dbReference type="FunCoup" id="I4Y6I0">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6I0"/>
    <dbReference type="GeneID" id="18474507"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61394"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y6I0"/>
    <dbReference type="OMA" id="YSHFAIH"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF123">
        <property type="entry name" value="RIBOSOMAL PROTEIN ARGININE N-METHYLTRANSFERASE RMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="13">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="14">
        <location>
            <begin position="312"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="14">
        <location>
            <begin position="427"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="497" mass="56400" checksum="50367791AFFCD432" modified="2012-09-05" version="1">MSSSSESSVEEDYEGWLSDDVESKKTIGLTLNKEFDTPAAALEFDKQNGLDLLELIKKLDLDYYNQIRLINFIRKNGKDAVSSVKPTDEFFKNDEYLIPVIEADPLLFQLDNQDDWSDDEKPVDNTEERITKLQQQLNQSATFINNNLLNDNFVDNEYFESYDYNEIHETMIKDHVRTASYAEWILNNKDLIKDKTIMDVGCGTGILSLLAAKAGAKKVYAIDASNIVDKARENVANNDLSGTIEVIRGKVEEIKLEGVTVDVIISEWMGYFLLFEAMLDSVIVARDSYLKPEGVMAPSHMRIVLGAASTHSWWNERVAFWDNIYGFKMSGMPKTIFRSAQVESFDDDSLISDSVGLLDINTKTQKAKALNFSSPFSLTIKKDETMHGLLGWFDTFFTDSKQQETPKDCNSQDPPSIDAILKDTGENHKDVSFTTGPHGTETHWKQTLFPFQKPLHVKEGDKISGTFTSKKSDRGLEMEVVWKHNDNEEIKSCYKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6T5</accession>
    <name>I4Y6T5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin Pls1 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_22087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960338.1">
        <property type="nucleotide sequence ID" value="XM_006960276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6T5"/>
    <dbReference type="STRING" id="671144.I4Y6T5"/>
    <dbReference type="GeneID" id="18470908"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22087"/>
    <dbReference type="eggNOG" id="ENOG502S3E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066479_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y6T5"/>
    <dbReference type="OMA" id="LGQCPLT"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24718" checksum="B8E50D1C5B3EB785" modified="2012-09-05" version="1">MPTKTLFSVWSLFDICLLVAGSVTISVSVSWASPDLLRDLVLNESERKAGLSLGIYIIIVVAYSVFAILRRRAIYLKIFNLLLITLTLFAIIVASSLWILSLKQHKFMRSVWTDLSTETQVNIQNELHCCGFQNTTTSGLFDSNANTGFCADLDSKDGCMRPLISYSNDYLNQTFSTIYGFVVILICLFLATVCIINERAKEDRFRRIDAKRNVNKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y718</accession>
    <name>I4Y718_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960268.1">
        <property type="nucleotide sequence ID" value="XM_006960206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y718"/>
    <dbReference type="FunCoup" id="I4Y718">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y718"/>
    <dbReference type="GeneID" id="18473036"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58603"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301143_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y718"/>
    <dbReference type="OMA" id="PEIFASH"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="863"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="993" mass="114070" checksum="34FC86941309A4B8" modified="2012-09-05" version="1">MDTASVDEKNKSKIRQWDSSDDNYLKLLSNDSRLYNSISKSSLKQPSVDNYKLSKPKYQWFERPEKDPPLALDSKVKLLYPKDTNNLVDQIRNKLSISPPIRFQKFHYKDAAQVNEELVPIRLDFDQDYLRLKEVFCYNLKEPHITPKLLAISLCHDFGLNEYTAAHHIEKAIIDQLDEWKSNVHEYLNMHGPSTSTNVGLLDQSELNWWNSIKNDSIPDDINVKEELDTNIDQELEEDIRILIKLDIVHPPNHLIDQFEWPLSTSLQEDAPELFATNFALELGLPGEFITSISHNIREQSSFYLKSLSKLNHPIDEKDSLLKIPDEDFRKSFLPQLIDHQLERTPRDAAEFTPKLEPVSSEDLITYEKDLEKDNRRRKRLQKNRKTNSSILTQDREPIKTFRTLPQFPETYISVPHSFLKDQPVVGGNNQNNQQLPTNYPRRAAAAKASLNISTSAQAELADIDNNPEDEDYGGEDSHFDNFNSTMQFNEEENRYVQKPLQIQPFDQSKMAITKRPRFIQEVPTKIDYNPIPRLREGAKMFTTGNNKAMKYGHGIAFKKDLSPGVEVKKLSAATINIYSYFSTENQHENIINGIWHCSNCGVPEMYAIGRRKGPMGDKSLCGECGKYLHKMRKNKPVVYNNDPEYHKGLREQMERENEERNQLQKANAQRYRKEMKASRQAQKVAKEAEQLDFYSNSHKRKQDLDFSDEDDTFEYKRGKRKSIDDDEDDDDYNEGEEEKGLPQTRSQRHRQVQLPPQPSPTSSQSEAFGDTSKTRQSQSTPTWLSEAAKQLRLKYPNDQFIIVEKPSQAGEVQEWRIKCLDCPGKMYTPGPGMTVENFEKHLKNRQHKQKLMARLGITDGLSPLNGPSTSLSPMSHPHQQGLNPLSRPSSSHQTPMQVAMSQAPSQQTDILAAAMQHASSQHDQPAPQQSQGPSQLYNQEQFINIPHDLPSDLSNDLPGDLPNSLDISNIDMDMIGLPSFDFNSQNDDQSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y789</accession>
    <name>I4Y789_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">WALSEDRAFT_58541</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 29">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960165.1">
        <property type="nucleotide sequence ID" value="XM_006960103.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y789">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y789"/>
    <dbReference type="GeneID" id="18473029"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58541"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y789"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="700"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="919"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1407"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EIM19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1504" mass="171541" checksum="4F9909374B7225F9" modified="2012-09-05" version="1">MKIRITNLDYNLFKPINYFDDNLSSFSDLPLANSPILRVFGRLDTGQMACAHVHGVYPYFYIEYKHSVTPEKVRDYIHQLGLSINQSLSLSLRRNMNDKQSTTQFLRAIVICKGTPFYGYNVGTRPFLKIIMNDPKHIPRLVQLMESGQLMNTTFQAYESHAPYLLQFFTDYNLYGCDWMQVSQAKFRLPLPDPPITDWDNESAQDSTVNSFSINEGDTHTVPRDTNCLVEFDIRASWIENRYQIAPRYIHNTSIEELVPDDKLLPSLRELWVNEEKRREAAGLESSIKIQGSVKGGRNDSKTYPRWDALEEILDSFHERIIDQDKDDDFLSHFTEEHKLMTIFESTEALYRPSERRKVPQNEDSSLYLDISSSQPNKDIEPIVSQQLASQKTEFMEMDIDDMAYDSFAQNNVFNGVPRRDLAIRESTVLSENRESIRQLSLMDSMFKSSTDPPLKREPTLEVIPDSQESEEPERKRSRSDSSELLASQEYDAILASLSQREIMPGVTIGMVQEKIEKASPQKDVVLSGQLTTIPHRSQPHESDCGVLYEYKIPPPTTDEAMRSFRDNTLPSKVYRDPYYSEPTDVPERPREYAGRVFVLKGDEIPSWDAKYDTVSTQGIRHFEYAPLPPSKRDVISAYGREAASTQRAIHTQIEGPPSRQKFGLDASTASGEKNHIPREHDIQTQITMMIVEVFAKNIGNKVPNPEHNPVEAIFWVFQSSDDEVESGMVVVEGETKYKLNETNMEIAINEADLIFTLIDKVQEFDPDILAGWDTELGSWGYLVDRARIEIGLELSEETSRVKSRTMRNITGGQKWAEMKTTTFTSPGRHVFNVWRLARSELSLPQTTFEHVSHSVLKKRLPKYTSETLTRWWTSGNVSSYARVLELFSLRVKMIGDILNSMETITKTAEFARTIGVDFYSVITRGSQFKVEALMFRIAKPENYVLISPSRNQVSGQQAAEALPLVMEPQSAFYKDPIIVLDFQSLYPSIMLAYNYCYSTCLGRVKPYEGHYKLGITEHTTSSKVLDSLKDDINFAPNGMMYVKPHVRKSLLSKMLAELLDTRIMIKQSMQENREDKYLRKLQHARQLSLKLMANVTYGYTSASFSGRMPCVELADSIVQTGRETLERAIRFIDNNKEWGADVVYGDTDSLFVRLKGKTQQEAFETGADIAEAVTKSNPHPVKLKLEKMYLPSVLLAKKRYTGNMFERVTDEVGIFEAKGIETVRRDGIPAQSKMVETALKVLYKTSDLSQVKSYCVKQFNKVIQGRVSIKDFTFAKEVRLGSYAPHAVPIPGVMVATKSLTDDPRATAHYGERVPYVITEGNSDRQVDRAVKPEEMLSNSNLHLDAKYYIEKVLIPPLERIFNLMGADVHSWYATMSRKFKPEARKPFAITRKGGVIGNYVRSGTCETCGEISKEPVCTDCLGDSNVSDTMYKLLSKKYRTTLKMRDIQTICSSCAHVHPSQDVPCVNLDCEVLYKRSQNQCDIDELEGLDELLSNFDHKLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7L5</accession>
    <name>I4Y7L5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960095.1">
        <property type="nucleotide sequence ID" value="XM_006960033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7L5"/>
    <dbReference type="GeneID" id="18474433"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61274"/>
    <dbReference type="HOGENOM" id="CLU_832102_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7L5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="334" mass="36795" checksum="79E6FC13D0F2CF38" modified="2012-09-05" version="1">MLVLKLQDIYSGILVIALLTLAQITYAFHVTSSNGLSSPPKANVGDTYSSFGSEATNGISDKKMWPGALNALPMTNGTRTSVDKRANQRPAAFVSWVRTSTDLTFSVVYAVSAPCVKNVWSLADVYYNTGLPGNAILNWFEESLTAGEGSDSWLNPVTWPDVLQGETADAINYYSIHEDGNVIMSVSKVTIEVNDNTWFDPEGIGSFIWSVAESMGLGTNVYSNWVPTNEEQAPPGGWRREEGDNEQDYHSIAYLYAANDNVSSEELEFVFKAIGDNEVSDIVDEMQHNKSSIKRASTYNCQSLDGRQCYSGITPYVSTHHQSTCYGYHEGFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7N2</accession>
    <name>I4Y7N2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein family 31/32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_40479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959905.1">
        <property type="nucleotide sequence ID" value="XM_006959843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7N2"/>
    <dbReference type="FunCoup" id="I4Y7N2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7N2"/>
    <dbReference type="GeneID" id="18472175"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40479"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y7N2"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="605" mass="69304" checksum="0674461FE9E0F1A3" modified="2012-09-05" version="1">MYYLSSYIGRNIYRRIHPNTLPSSKLLVSQTYRLRSQPQLHTHSIKHQSKQPNDNRKYSPFFRSLIRDLPHPHRPTKDELLALANGFFQRLRIRWKWWTIRGFRKFNADDLSAFISWLLLGHIFWILVGTTTFFSAIFATANSLRLQNYIAGAISNYLTQATGVTVAFESAILPKWKDSRISFKNVHVSRHSGGETLPPVQPDSSSVRRKIIWDDNAHDHDEDNELALRIAPPPPQETWTMFDLNIDSVDVELSLWRWLDGKGLVKDASIKGIRGVLDRRGVKWDYDNPLEPKDFRHAHHPGDFELESFTIEDLLITVYQPSDFRPYNVSIFKGELGTLRKQWLCHDFLAAHAMTGQFDNSLFSLHKPQSISRTHNYDVDRVSRFRIDGVAVDHLQAAAGMTGPTAWITHGKMDAVVDITFPFQQDEDLFNAIMEGLNNLGAVVQDENRRIPGQAQLTKPALTSPDQTQQQDEISYSKERVKVDIDLRFRDVKASVPYYTSDLTYTNNALVRPIVAFINANRTLIPILSHVEMAIDEFDGSWTIWETGLMSAVSERIYDALAHHVTSTEANNQRVKYVTLWSLQLSARGAIQTLRNILGQSRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R9</accession>
    <name>I4Y7R9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959941.1">
        <property type="nucleotide sequence ID" value="XM_006959879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R9"/>
    <dbReference type="FunCoup" id="I4Y7R9">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7R9"/>
    <dbReference type="GeneID" id="18474376"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61182"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_12_3_1"/>
    <dbReference type="InParanoid" id="I4Y7R9"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="188" mass="21495" checksum="8DDB861494749CE1" modified="2012-09-05" version="1">MRFLFLGLDNAGKTTIMKRINGEDIKSISPTLGFNIKTFVHRGYTLNVWDVGGQRTLRPYWRNYFEQNDGIVWVVDSSDRLRMEDCRAELFDLLSEDRLAGATVLIFANKQDVNGAMTQDEIKDTLQLDSIKTHTWKIQSCSAVTGEHLLEGLDWAVADCSKRLYYSSEPDFTTKKDLPKLFNDEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7S5</accession>
    <name>I4Y7S5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor prp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959947.1">
        <property type="nucleotide sequence ID" value="XM_006959885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7S5"/>
    <dbReference type="FunCoup" id="I4Y7S5">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7S5"/>
    <dbReference type="GeneID" id="18474379"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61185"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7S5"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000384">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="934" mass="103441" checksum="C59701BD08AF0085" modified="2012-09-05" version="1">MSRTNPLKNNASKFAFLSMQAPPGYVAGLGRGASGFTTRSDIGPAREAGTMEEAVSDLQSKEIEPDQFQDPENETGLFAGTVYDKDDEEADKIYDMIDQRMDEKGRARREASEKKAQEAYLAANPKIQTQFSDLKRSLATVSEEEWGALPEAGNITGKRRKNNTRNDGKTYVVPDSVLAGARDRNDVNTSIDDEKGVATPASSGTVTDFREIGQARDKSLSLRLDQLGGAASSTSNATPSPSSTNTASSSASTSGTSGTSTSVDPKGYLTGLNSVQLKTDAEIGDIKKARALLESVIKTNPKHAPGWIAAGRVEEVAGRMAVARKVIAAGCDNCPKSEDVWLEAARLNIPQDARVILANAVSHLPQSVKIWLKAVDLENDPKSKRRVLRKAIEYIPNSVRLWKEAVNMEDDPQDALILLARATELIPSSVELWLALARLETPDNAKKIINKARKTIPTSHEIWIAASRLQEQIGASSNDIDKLMNNGVGSLRSAGALLSREQWLKEAEKVEEEGSPLTCAAIVKATVYQEIEEEDRYAVWMDDADALEDRGSIETARAVIAFALKVFPERSKLWRRAAELEKQHGDRKSLTEILKTATQYCPKAEVLWLMLAKEHWLGGDVNAARQVLGDAFNANPSSEAVWLAAVKLEAENKEIKNARMLLNKARLQSGTERIWMKSAVFERQHGDKAKALEYVNQAIEKYPKFDKLYMIKVGLIDQSQHKEIRDTFTTGLKLCPHSVPLWILASQFEERMGVIIRSRALLEKARLTIKNSDILWAEAIKVEERANAANQAKALLSKALQECPNSGILWSIAIWMEPRPSRKTKSVDALRKVTDDPTIIVTVARTLWMEGKKDKARSWLSKSCKADPDNGDHWAWWYKFELQDGTKENAQAVLDNAKQSEPHHGQIWQSVIKDDQNLSKPFEQLLRITASKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7U9</accession>
    <name>I4Y7U9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_40560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959970.1">
        <property type="nucleotide sequence ID" value="XM_006959908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7U9"/>
    <dbReference type="STRING" id="671144.I4Y7U9"/>
    <dbReference type="GeneID" id="18472178"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40560"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_15_0_1"/>
    <dbReference type="InParanoid" id="I4Y7U9"/>
    <dbReference type="OMA" id="HIEQPDP"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="514" mass="58375" checksum="3439382860BB1E5A" modified="2012-09-05" version="1">MLQNLALLLISIACIIPINVLWQLLPKKNTSAPPLVFHWLPFIGSALDYAIDPLEFYRRNQERYGDVFTFILLGRPMTVVLGTKGNKALFASSATKLSASEAYTNLTSPVFGSGVVYDCSHSTFMSQKKFIRSGLSVTQFRAYVSMIVDEVELFMKNNLNGLSEGKIPAFETLAQLTLLTSAKTLQGHEVRKAFDEKLLSCLYHDLDKGFTPINMILPGLPLPVNRRRDVANKAVSDMFVRIIQARRKNPLPEEEYDMISTLNEKQYKDGTLLPDNHIAHLLISLLMAGQHTSSSVLSFAMLELGRRPDIWDALLKEQKENLSIHSTDDDINGNGCQLKPLEYEDFEKLPLLGAVLKETHRLHGPVHSVIRRALTDFEYIDDNDRAFIIPKGHNVVASPLYTQRSPEFWKNATDFDPYRWFKNDVYKESEEDIKVDYGFGMTSDPKESPYIPFGAGSHRCIGEQFATLQLMVILSTFVRKLEIKTEGEMPNHNYRTMIISPLSPDNIIYRTRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W2</accession>
    <name>I4Y7W2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959983.1">
        <property type="nucleotide sequence ID" value="XM_006959921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W2"/>
    <dbReference type="GeneID" id="18474398"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61215"/>
    <dbReference type="HOGENOM" id="CLU_171296_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7W2"/>
    <dbReference type="OMA" id="MRASFTI"/>
    <dbReference type="OrthoDB" id="4932133at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045992">
        <property type="entry name" value="DUF5948"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19373">
        <property type="entry name" value="DUF5948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698636" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11778" checksum="65C2FAF98A1ED71B" modified="2012-09-05" version="1">MLPRDTLSSTMFKVLFFAPLLALVAAGGSEVCLNKKAGCVEAQITKDCCAAVKQSAYFSEVSSTCVPYAANGINTGDMVDCCESRGAGSHGGETVTDMSNRKICLDPLDGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y859</accession>
    <name>I4Y859_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_21126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959872.1">
        <property type="nucleotide sequence ID" value="XM_006959810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y859"/>
    <dbReference type="FunCoup" id="I4Y859">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y859"/>
    <dbReference type="GeneID" id="18470875"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21126"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="InParanoid" id="I4Y859"/>
    <dbReference type="OMA" id="CKQHITL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="269"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="626" mass="70271" checksum="09BAB24720979346" modified="2012-09-05" version="1">MSKRQIPNEYDILISPNQPPQKSTKVGDSELRITLLGAGQEVGRSCCLIEYKGKRIVCDAGVHPAYTGLAALPFIDELDWSTVDALLITHFHLDHAAALTYIMEKTNFKEGKGKVYMTSPTKAVYRFMMQDFVRISTTSAEDQLFTESEMIASWRSIQVSDFNQEIVPASGVRFTPYPAGHVLGAAMFLIEIAGLKVLYTGDYSREEDRHLHAAEIPKEQTDVLIVESTYGVQTLENRPEKEKRFTELVHNIIRRGGRVLMPSFALGRAQELLLILDEYWQRNPDLHSIPIYYASNLARKCMAVYQAYIRTMNKNINRRFDSGENPFQFKFISELGDLRKWQDKGPCVMLASPGMLQSGTSRELLERWAPDPKNGLIICGYSVEGTMAHSIVNEPDEITGINGNKIPRKLSVDYISFSAHVDFTQNTQFIDEIKPQHVVLVHGALTNMSRLAAALRSRYADRGLDIKVHMPKNAEPLKLEFKPEMTAKAIGKLAEKQPAEGEIVQGLLVNKDFTYTLLDRSDLKDFAGLATNTIIQQQKVNIGVSWELIRWHLEGMYGSINEGIDNDGVPTMRIMETVDVKQAPENNLLLEWKAGAMNDAIADSVLALTLSIETSPVSVKSELPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y884</accession>
    <name>I4Y884_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_65534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959664.1">
        <property type="nucleotide sequence ID" value="XM_006959602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y884"/>
    <dbReference type="STRING" id="671144.I4Y884"/>
    <dbReference type="GeneID" id="18475030"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65534"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003590_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y884"/>
    <dbReference type="OMA" id="NMYDATY"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="216"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="542"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="870" mass="99574" checksum="C484DB5B2D7189D6" modified="2012-09-05" version="1">MINNLIGRPSEQWRRTQVVLVILFWLWRLLKGDRNGLRFWYIKSINRRLKRFTPYQIIVATLTTLYAIRHFDALLGLQAPEPLAHLYSRSYYRATWLSNALDAGFATAMSIRKPKWLKDLAGPVFGLYYLFWTAEADEKLMKFRATCTVEFLRTTGEKLSNPYIRAVTFLGRPRCRIVREVLLPRPKSSKYTKPISCLMFFDGTQEELEACTELVMDFPGGAFVFMTPRDHEERLRWWAKEGNKKVILSVNYGKSPEYPFPWAIDEAFDLYNILLETNGRLLGIQSDNLNILLAGDSAGGNIVTVVMFKILESEVPLKHPVGIVLTYPALDFNFTSWMSDENLEVLRTEQSSVDLASLFESKDHLAHKSPLSVTCDVPEKNIPRRKSWSNQLSHWASSNSLSNLGSVSPKAPYSAGAQIASATVMQAPSKSTSSLRYDSNSPKRRRLLSFVDDPPKFDFEVNEQDVLNIDTTDTSESDKGSEFTSDSQKPLYERVIAEPNEHVRRELQKELQKEHMKANERIRSKKKEPIGTRLTMTSRSGFFNDRIIPPSVMRACALLYIGPKNRPDFKTDYYISPILAPSHLLEQFPTTLIICGERDPFVDDSLIFAGRLRKAKLARQAAAMNEQNNFNSSNEMMTPTDGLGLNIPQPKGDHLEDHIVHEDEDDWVHLRIIEGMSHGFLQMTGVFKESLLIVKKMNQWIEESFLHALEKENAENAENAEKERLEREKKDVSENLPNQSRKGSEHEYEEPLVFSTKKAATLSTVFSEPPTQIHTPNNDQLSQLRVPPRAHSKPHQKRTQSTPPPLVIKTQSSDRRKSFEKEKKKEEMNNLLLTEAEVLRRRRLEAVMGMGETRSANISSDEEDMNSNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J9</accession>
    <name>I4Y8J9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_47981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959779.1">
        <property type="nucleotide sequence ID" value="XM_006959717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J9"/>
    <dbReference type="GeneID" id="18472434"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47981"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8J9"/>
    <dbReference type="OMA" id="SWWNPKG"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="570" mass="64941" checksum="D31E29E883C762A0" modified="2012-09-05" version="1">MATESTPLMANDFVQDSVVHTVAYDPESDTDKKSLDDKLEDVPPLSRDPVQRTGILSLFQRKKDKTDPNNIATQPSVFDTADAKYFEPSPEYENKHRFDPLFRWTWGEQTKVTRKADFRILPWCMLLFFALDIDRSNITNATADNFLDDLGLSQSDYNLGQTLSKIGFLVAELPSQLVSKRVGPDRWIPTQIVIFSIISGAQFWLRGRTSFFATRFLIAFFQGGFIPDTILYLSYYYTKTELPIRIALFYTINPIADLVTAFLSVGLLEMRGILGYEGWRWMYLIEALITLVIGIAAFFYLPAGPTQTKIFNEKEEKIITNKILRDDPGKASMHNRQLLTPRMLLKSLLDWDQFPLLLLGFTFNLPSYPVKNYLQQSFKSLGFSTVMSNLLTIPYIAVSIITVVAAACLSELVDDRGFISTIQQIWMLPCFVALLVLKSPGPWSYFAISTVLLGYPNVQPIMISWCSANSGDVSNRTVSASLFNMFVQVSAIAGSNVYQKDDVNYTKANSGLIGVLCVNILLFPATKLYYHLRNRYKEKKWSELTVDERIEYIRTTKDKANKRLDFRFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8P7</accession>
    <name>I4Y8P7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_20706</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959596.1">
        <property type="nucleotide sequence ID" value="XM_006959534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8P7"/>
    <dbReference type="FunCoup" id="I4Y8P7">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8P7"/>
    <dbReference type="GeneID" id="18470852"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20706"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8P7"/>
    <dbReference type="OMA" id="HQTLYSE"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="159" mass="17045" checksum="BAA1F27567B84AFE" modified="2012-09-05" version="1">MLSRAFRGAVQVPRIASRAYASEAGAADKLKLKFALPHETLYQDKEVIQVSVPAETGEMGILSHHVPSVEALKSGVVEVIEAAGQSKKYFISSGFASVHPNNTLTINAVEAFELSAFDKSAIKQGIQDAQKLKASGSEVEKAEAEIELDVYSELEAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U1</accession>
    <name>I4Y8U1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_47781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959639.1">
        <property type="nucleotide sequence ID" value="XM_006959577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U1"/>
    <dbReference type="FunCoup" id="I4Y8U1">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8U1"/>
    <dbReference type="GeneID" id="18472427"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47781"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008679_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8U1"/>
    <dbReference type="OMA" id="HKAGPPF"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="225"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="587" mass="66139" checksum="A7E04FD1061F505F" modified="2012-09-05" version="1">MSFDLNQISKRNNRYGIHDIRDLVLHLAADGQKKNWMNVIHHSNIQHTVVLMVSGITSESLGINKPAINATHPFSLSAEDAEANKLPIINQLYSHGLPVRAPGDSQRLYSPAQHILNSPIPPPEKLRQQKVAQEKAGVNLSNPGKLSPPVFLIDIDQMRENAYPMPSWLGDDVRALPDYPLPLNDGIEDPQPLDNLPVEHRTTIQEDGWLETPKLDIYPRSNNPQVYGLDCEMVMTDQGSELARVTLIDYATSQKVLDELVKPAGNVVDYLSKYSGITREILDGAVLNHEEAQRKFADFITPSTILLGHSLESDFKAIKLRHPWVIDTALVYEHPRRMPFKPSLKWLMKKWCDKDIQSGNDGHDPEEDAKSCLELLRKKIQYGRNFGSLPNDMESIFARIARVKQSHLADTNEDHKVGACVDYGNPAQFHGMKAKTSISCKNDDEVIDGIIKTAQDHDLVYGRLTELQIALGWSNTSNDKETTRGDSDNTIQSAPLDSAYQALNERIKRLHDALKPNTALVIISPHSDPRPSLELNQRRLAFQDLYKAANTDVSKIDKDKIYTREDDERLLHEAEIAKSGMTFFRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Y0</accession>
    <name>I4Y8Y0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959448.1">
        <property type="nucleotide sequence ID" value="XM_006959386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Y0"/>
    <dbReference type="STRING" id="671144.I4Y8Y0"/>
    <dbReference type="GeneID" id="18474241"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60909"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077196_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Y0"/>
    <dbReference type="OMA" id="GTIMKFD"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="20081" checksum="B71088F1985751E3" modified="2012-09-05" version="1">MISRVLLRGRSAASYPSITRAYSTKNTVPQKTTHDENIKEHKASGLTTPHPPKDVLTAEVISGAPETLQRRQVRIYKPTKNTMQSGTYNTHQWRVDFDILQGGGRWEHPLMGWSSSADYMQGTHVKFQSKEAAIHFCEKQGWDYFVSKPRSPKFKTKQYAANYYHSAGKVRLAHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y904</accession>
    <name>I4Y904_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959472.1">
        <property type="nucleotide sequence ID" value="XM_006959410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y904"/>
    <dbReference type="GeneID" id="18474252"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60922"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_4_1"/>
    <dbReference type="InParanoid" id="I4Y904"/>
    <dbReference type="OMA" id="VYRESGW"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="33310" checksum="16EC63AED5F27F76" modified="2012-09-05" version="1">MSSTSDQGSELRSFFAGIGSGLTKMVVGHPFDTIKTRLQCSPPGVFKGPIDCLRQTLLKENILALYKGGLAPAISWGCSDALLMGSLHNYRILILENKLKFFTEPMPGSSDKTRLSLAGQALAGMGAGWTNGVVAHPAELVKVRLQNQMERNKSERKYSGPWPIAKEVYQQHGIRGLYRGYAATLLFRSNMAVLFSSFELCMRGFKKYEVNVSVGTASFISGGIGATFFWICALPFDNVKNRLLFDDLNKPQLKGVIDTATKIYKTGGLRNFFKGFTTVFVRAFPTNAAALGTWTYIMHAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y982</accession>
    <name>I4Y982_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_65409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959550.1">
        <property type="nucleotide sequence ID" value="XM_006959488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y982"/>
    <dbReference type="FunCoup" id="I4Y982">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y982"/>
    <dbReference type="GeneID" id="18475015"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65409"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y982"/>
    <dbReference type="OMA" id="CTFVDAA"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="323"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="826" mass="94145" checksum="E7BB4125FD603191" modified="2012-09-05" version="1">MPKIKCDGPSKAEQGLKCTNCNNNNFTCTYVEAAKRKGPPKGYIESLENRNRRFEMLFKKMLPDYDYNSEVGAPIDRDSFETGCEADTSRWNKEKMELPTIEKAFHPTKEIDDQSDDELEERMQQISLSAQCEDNTRYLGKSSSMYLMATLDQYKPPDEPLITREYIEQDRRPEFWMDSEWIMEENKDFPSISYSVEELPPPDLLDHLVKIFFERFNVYFPVLHRATFEADLHKRKHDVRFGGLILLLCAAASRYSDDPRVVPKDDKDEFGNVKNWRFAGAEFFAKFKMHCHNFILTAARLEDLQSIILMVVYLQGGPFSHACWALNSVGLVLAQDIGFHRKRVWGDPIQNELRKRAFWSFYVMDKRLSAVLGRPCTLNDENFDVELPSVLPDEVETEMQVSIAQFNKLIELTAILGEVLRTSYVVNKRKRPNNANIPEPKRTLMDVAALDSKLHKWLESIPPELAWDPNCKDNLKFTFMCMLQTTYYLVQIYIHRPFISTPKRPSPLGYPSLSICTNAARSCIHVLSHLQERNRSVKIMDSWIGIGSFTSSVILIVSACEGRRNSTDPSAPIPEMKEINMGIQVVKELEARHLHAGRAHDILRKLVNSIGQISTEESPNTTSRATSNFSASSSLSIDSNLFLGGTARNTSRPQQRRKIAKKPSHTRKDTYNLESLPMSTNDLATHIFYPDMVNDTATTENTTTSLTEMANLVDQGVFPSGNFDFTAPTSSEVMPQSTFVQPPTSQMPKGYNDVNMAGINTLTDYDMLGNSNPLTNMFTSSPEDDTKPSVTQDAVPQQDLWSLLPDSTYNTQSEDWTNFFRFTQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9D3</accession>
    <name>I4Y9D3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_20300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959315.1">
        <property type="nucleotide sequence ID" value="XM_006959253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9D3"/>
    <dbReference type="FunCoup" id="I4Y9D3">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9D3"/>
    <dbReference type="GeneID" id="18470832"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20300"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_7_2_1"/>
    <dbReference type="InParanoid" id="I4Y9D3"/>
    <dbReference type="OMA" id="GQELRWQ"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000088">
        <property type="entry name" value="Histone H3-like centromeric protein CSE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="108" mass="12760" checksum="ACCA9AA00701F6D2" modified="2012-09-05" version="1" fragment="single">GVKSKKRYKPGTAALREIRKYQKSTDLLLAKLPFSRLVREIHEDFLDSAYRYDYHPSRWQSSALMCLQEAAEAYLVHLFEDSYLCTLHAKRVTLMQQDIRLARRIRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H9</accession>
    <name>I4Y9H9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959407.1">
        <property type="nucleotide sequence ID" value="XM_006959345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H9"/>
    <dbReference type="FunCoup" id="I4Y9H9">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9H9"/>
    <dbReference type="GeneID" id="18471643"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33242"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="InParanoid" id="I4Y9H9"/>
    <dbReference type="OMA" id="CRNAAMR"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="39797" checksum="308183F7288199DD" modified="2012-09-05" version="1">MAFAAGQAVIFYTLRYILNSNDPLKSKRQGTKSKSAQILDRLGRNDITLNEYEEIIACEIVLPEEINTTFEDIGGLQHIVSNLKENVIYPLKLPSLFSGSQNLLSPPKGVLLYGPPGCGKTMLAKALAKESNATFINMHVSTLTDKWFGESNKLVAGLFSLAKKCQPSIIFIDEIDSFLRERGRGDHEVTNMMKAEFMTFWDGLSSESNDRILVLGATNRPNDIDQAILRRMPKRYPVKVPNDEQRKNILNLILRDTTLAQNFDVNQLVDITNGLTGSDLHELCRNAAMIPMRELMRKHDPSTLEHDISKIKPRPLTITDFMTASNEDEDDMPTYDPTIDGKIRQIRDNLGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I4</accession>
    <name>I4Y9I4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959410.1">
        <property type="nucleotide sequence ID" value="XM_006959348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I4"/>
    <dbReference type="FunCoup" id="I4Y9I4">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9I4"/>
    <dbReference type="GeneID" id="18474230"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60892"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y9I4"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="117" mass="13143" checksum="745BDFDBF67B41B0" modified="2012-09-05" version="1">MATIQNFSKDDPFAVDEDFGGGSESAKNVGNQQNYIHIRIQQRNGRKTLTTLQGIPKEYDLKKILKAFKKEFACNGTIVDDEELGQVIQLQGDQRFKIQEFLITEGVPKATIKMHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9M7</accession>
    <name>I4Y9M7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959203.1">
        <property type="nucleotide sequence ID" value="XM_006959141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9M7"/>
    <dbReference type="STRING" id="671144.I4Y9M7"/>
    <dbReference type="GeneID" id="18474165"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60791"/>
    <dbReference type="eggNOG" id="ENOG502QRPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020600_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9M7"/>
    <dbReference type="OMA" id="GDECTIV"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="225"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="435" mass="48911" checksum="EE0F35E86268BDD2" modified="2012-09-05" version="1">MVDEIEGVKHGNMTDNYRDTSRVSSSSSDESDDNESEVEIVKHRHPAERKRRLSSLRRLKFTRASRRPSSSKNDNDRSSSPPLEPLRDGTSASETESAPESSFRPKNNAFDDADDEVSDEDLFDNSQVDSDDEDLFNYDEELYYNTEANAQFIIDKPLYLPPADDQHLLDEGPNITKPLHDTPHKRSNNLDLNLTGPKFEKNRCTITIRQGDPDQALITNNRRRKRYILASDLSHESKYAVEWAIGTVLRDGDELFIATVQETDTKLDGRDGKKADKTKSQRERAAFSQYLTKHAISLLQRTKLHVIVTCQAVHAKNSRHMLIDMIDFIEPTLAIVGSRGRSDITGILLGSTSHYLVQKSSVPVMVARKRIKHPPRKRGNADLQNRRHVPLTSAAIDSVAARDESKLQAQEDEFASESGDGDAGDEDEDGKELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9P7</accession>
    <name>I4Y9P7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959222.1">
        <property type="nucleotide sequence ID" value="XM_006959160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9P7"/>
    <dbReference type="STRING" id="671144.I4Y9P7"/>
    <dbReference type="GeneID" id="18472970"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57984"/>
    <dbReference type="eggNOG" id="KOG2009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452840_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9P7"/>
    <dbReference type="OMA" id="EDQHAKE"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="443"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="603" mass="67057" checksum="10606FA3D50464B7" modified="2012-09-05" version="1">MSGRINKGTTKFQAKVGNRKPRKVAQQPTPASTQENVTAGENSELNKTSADTLNNRKDVPPTPPVTQENNKRAAVENTEEAAPAQKKQAVAIGIATPEPSQQSKQSQQKNAPLPVMPGRSAQPLSFNQRFQQSQQSHQPLNTRASQSAPTARPLTTRAAHAPLQTRASQAVASTSAEASTPAAPANPEEKHVKEKNDKGDSPEGEGVDQLSTPGGSPQNKKLSARQLRTQKLKMKRRPIEEIWSEDPTAEPIDTSTFKMADLIHDPGVGRLSSRVIDVAKKHAEMKLRRREQKAKLKYMTEEELNLDGGDDGTGRRRTAEDEERIKKEQEEAKRKKKEDRKAEKKRLKEQKKAEEGVEEGAEEVEGDQEEESSSSDDDDDDEKEQQGPQMRVVDGQLVVDEQSLLYDRSANSRNDTSGYEVTDELDSDRFVNTNTWRGRGRGSHDRWTRLETEMFYDALSRFGTDFEMIATLFKGRTRRVIKAKFTREEKYNSDLITYALKNRKPFDMIEYGKFIGVDFSGPPPEIRVPEPVTDSAVKKDEVVDGEEEVVNPDEEHRGRRPSLSGASAKRKQSRGPGGRDPENEEGAEVVGIVDEGGLVTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9R6</accession>
    <name>I4Y9R6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959241.1">
        <property type="nucleotide sequence ID" value="XM_006959179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9R6"/>
    <dbReference type="GeneID" id="18474178"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60810"/>
    <dbReference type="eggNOG" id="ENOG502R1WK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452134_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9R6"/>
    <dbReference type="OMA" id="QAFMIGA"/>
    <dbReference type="OrthoDB" id="2549326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="608" mass="64069" checksum="B25033F07012CB0E" modified="2012-09-05" version="1">MTAVDDSSMKSDNRSQSNKSSVSVQTNNRNDIAIQTSPALYDNNEASQNGLLAPSTTSLAPTAHNGVYGNNSNIRSRSVSFASTAAPSRVGVNDPYAAFRSKSTISLALPTGDAIEIEDEPDQLPTDQKPGQRTPSPQQPSTKMQIFRRMCIINLVAFSFGIDSTLWLPSVYNFILTLRPNDADRYLAVTQAVSALAQFIVSLSIGVFAAKVHSLKWTIVVCIALSFAGNFLYSCAGVGALNNVGAIIGGRILCGIASGSSGLAMGFIAISTANVDRLEALSQYRTYAGIALVLGPALNALFGLIDIKIGNYTINENNAPTYCSSFIMALLAILLGLFLSNKTKPAPNPIVPAIEFFRRGHYGPSLIILCSMLSSSYVSALILYVLPDRLSSFWGFSTGVQAGLQTAVYAAGLIGSLLSSYIRDGLGRLVLSITSWKNGVDKVTLLERAKADGGVSAGAPLYTGIGLEILLGIVSFLWVSLGLIAMMISFGLDFVYSSSQASTAAGFLIGCAVVMVGYNIQAAVLPTLFSKSLPNDLRVALTPWYGATVAMGKILAPLITEAITKATPTGGRTGGNQIGGYALALGVSVIGVITTFWVKYHLSHATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA27</accession>
    <name>I4YA27_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mis12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_29279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959081.1">
        <property type="nucleotide sequence ID" value="XM_006959019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA27"/>
    <dbReference type="GeneID" id="18471093"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29279"/>
    <dbReference type="eggNOG" id="ENOG502S72R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023795_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA27"/>
    <dbReference type="OMA" id="HAIDHTM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="31524" checksum="F494D0CC8958506E" modified="2012-09-05" version="1">MPVPEHYKNEFLTGHFGYTPLALVDDYVNHFNEPVGQIMDAIEDFFVAILAEQGLDIDSDGKFQNQIRQGIHRLQTLLEHLIDKNVDKMEIYLLRNILTIPDELECIPTAFLPQYCDLEIPSDLPQSEEEEQAEIDQLNAKRKELQQRQLEKLNRKLRSECRQKENAIEKQRREAKERETIIENITTLADKHITLTANLKSLHNNLIALKEVDPFQVTLPNTKSGDDLAIWQIGRIGYINWQSNRLIKDESVSKITSEFNSIANIDDLNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAB3</accession>
    <name>I4YAB3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_54907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959164.1">
        <property type="nucleotide sequence ID" value="XM_006959102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAB3"/>
    <dbReference type="GeneID" id="18472699"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54907"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="I4YAB3"/>
    <dbReference type="OMA" id="ARTMIQL"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="66"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="586" mass="63933" checksum="EE4973C8A57F715F" modified="2012-09-05" version="1">MNTPGEKHLEEKHNVSNTAPSSASTVTFNSKNISKDNLSDVAVKEERTDGLQDQTNLLPRKQVIIVFFGVCSALFCSILDQTVVSTAIPSIGAYFQAADKSSWVATSYLLTTTAAMPVHGRLSDLFGRKYALFGCLTFFFLGSLACAVSQTIEQLIIFRAIAGIGNGGIKTHVHVIISDIVPLKERGKYQGILTAWTCLANGIGPLLGGVFSETIGWRWCFWINLPLVGIALAVLQFLVPFKKVTGDWRAKMKRIDYAGSIIMFTSAVLILISLNWGGNKYAWDSAPVLVCLIIGLLLMVVFVLVENCKRIVNLPIIPMYLFRNVSVSASYICTFFGGMGYFGALFYLPQYLQVVHSYSGTVSGALMLALMVTQTIVSFLAGLVVSKTGHYISIIRTGFSIYAVGCGLYISLTYNSSLAKFIGYSIIAGIGAGNTFQTTLISVQAAVKRQDMAVATGGRNFLRMLGGVMSLAFCDTILRNTLQKGLSKMGQTDELIAAITSNPIDIKNIVSEDQVIATLGMYCNGVHNIFAMLTATSGCAFLLSFLIKQYSLERDDEKQLKEEGKKFVEELERKRKKPKTSSIQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC1</accession>
    <name>I4YAC1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958911.1">
        <property type="nucleotide sequence ID" value="XM_006958849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC1"/>
    <dbReference type="STRING" id="671144.I4YAC1"/>
    <dbReference type="GeneID" id="18471587"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32918"/>
    <dbReference type="eggNOG" id="KOG2237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_2_1"/>
    <dbReference type="InParanoid" id="I4YAC1"/>
    <dbReference type="OMA" id="LDPWFSH"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="423"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="628" mass="70295" checksum="436729BCA91AAECA" modified="2012-09-05" version="1">MASLTGLKMLVCSHMQSYDHLSNLVVMRATLATAAFSKTAKYFGYGISRSGSDWCTLYVRPSDSPFTEKSGSHETDKERFSDEIRYVKFSSIGWLGDSGFFYQRYDVTEGAHGAAHEDVAGLETDANENAKLYYHKVNTPQSEDKLVLEDPQNPTHMWSASTTDDGRFLVVTVAKDTSRRNLLKVADLNDSRNAEISSNMCWLDIISDFKHEYDVIDNDDSKLYIHTNEEADNYKIKTFDIASNVWSELVSEEDGVLVEAQIVNSDKLVAVYTRDVKSELIVRSLRDGSHLYRPFDKFTGSINQVTGERDHTKIYLSTTSYTTPGEVLCFDFEELEKRKCIDQASTVFRSAEVNGLDPKEFTTEQHFAQSPDGTKIPVFITRHKDTPKDAPFFLYGYGGFSISLLPFFSPSALTFVKHFRAGLAVANIRGGGEYGERWHQAGTKERKQNCFDDFLASANYLVDNGFARKGSIIANGGSNGGLLAAVVAQQDKMDLIGVSIVDVGVLDMLKFHLWTIGRAWCSDYGNAEEANDFDYLYEYSPLHQAALAQEKIYPSMLLTSAAHDDRVVSCHTTKMIAQLQHTQSEKIKLARLETKAGHGAGKSTEMRIAEATDKYTFAAHELGLKWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAM0</accession>
    <name>I4YAM0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_29215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958998.1">
        <property type="nucleotide sequence ID" value="XM_006958936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAM0"/>
    <dbReference type="STRING" id="671144.I4YAM0"/>
    <dbReference type="GeneID" id="18471088"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29215"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590802_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAM0"/>
    <dbReference type="OMA" id="EECTETM"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51186" checksum="2D734E53E99775A7" modified="2012-09-05" version="1">MEDQLQYLDQLGQFNVPGSRCHSCSKVFLVDSDLRNHLATSDECSKEIPLSEIDYLRAASNDIASSNNLINWYGEDLKRYPEDKKPVNTFSVHTSPSHHLLNEVTDLNGSEEDAAYDEDGAGDDSMSALPPAMRPTAAPMFQDQTLGFRKIESPDSHMKGESLMARRANYPAYDETKYNTAEEAMAHALSQVPDQSDPRPFKCPNPECSKTWKNRNGLKYHINHGNCNGVLKTLSRDEAAVSERPYACPVPGCNKRWKNANGFRYHMDHSGAHGRSARRLHEASGGFAGKSNLQSITSPQTTTKTPKGTRRSSRRSSRRIQYDEDEEDGDAELEEEDDYGDEEDDDDDDDDVEEEDDAYGDVDDAAALHPTGGSTSALPAAATDQLQFSVQGSQFPTGPNGKSFEINDGRSFEVNPVNSVDPIDPINPVDSAQPPVIGQTEPLEFTKIEHNDSITDPPQEQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAU4</accession>
    <name>I4YAU4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_19458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958741.1">
        <property type="nucleotide sequence ID" value="XM_006958679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAU4"/>
    <dbReference type="STRING" id="671144.I4YAU4"/>
    <dbReference type="GeneID" id="18470799"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19458"/>
    <dbReference type="eggNOG" id="ENOG502SCUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188578_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAU4"/>
    <dbReference type="OMA" id="YENNPRT"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="71" mass="8475" checksum="9B844D98AD3969D8" modified="2012-09-05" version="1" fragment="single">IYRSIDPLLGVFTGFLSFYLNETHPKTYREEPDRLISLIKWKLDQRRLSTQNDDNNDSDLNDLIQQFNNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAX8</accession>
    <name>I4YAX8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958797.1">
        <property type="nucleotide sequence ID" value="XM_006958735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAX8"/>
    <dbReference type="FunCoup" id="I4YAX8">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAX8"/>
    <dbReference type="GeneID" id="18475561"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69274"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_2_1_1"/>
    <dbReference type="InParanoid" id="I4YAX8"/>
    <dbReference type="OMA" id="NATKIHR"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="16993" checksum="6DC4EA6E6E829457" modified="2012-09-05" version="1">MPDPNTTLYLRNLPDKINKQELRSQLYFRFQSYGRILDVVALKTDKLRGQAWIVFDVLSSATSAMRAENGSRFYNKAINIDYAKTTSKAYQQYIGNSESLFSDAQKAAQGGIQRMVVSNASEASLGLKRAREAEELARSSENDKRIRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ1</accession>
    <name>I4YAZ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958808.1">
        <property type="nucleotide sequence ID" value="XM_006958746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ1"/>
    <dbReference type="GeneID" id="18475564"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69286"/>
    <dbReference type="eggNOG" id="ENOG502S598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654187_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAZ1"/>
    <dbReference type="OMA" id="SHDCHAR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="420" mass="48284" checksum="53E0E5519B275174" modified="2012-09-05" version="1">MNVFQLDQKHELYKFNNNLQSLPRTHINHLKISLLRLRSFYLYLLDDVDYSTLEDAITTVRHWELSVGIPAVDFNFSDKKYTSKSLNAHLELLDEIQILVDNYSNIHSVSIPAFNRTRSNGNTTGSSTGTTNNRTSTTNNSNSASQAAQTAQQQRNDSYVVINLSTIIPLILPLLFLVLKCFLMLYIFCRHGTWPRKLILATLTIGYSIWEATRFVHIRRHTISPQAQRQENNNNNNNGVNQENQANQANNENAYDALNRAAQMALNNPSNHIQTISLNPFERLLDYLAHMNLEYEARRLRIPGPVASSQPLPPLPQTRSGHGSRPQRQPLWYTRIVIPVSICILTLVPEIERRRSRALKWRYNAFKNIKATERERRERERVNGDENGGLRSPQMSTSPVTADNEDERVAEDTQVDHWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB93</accession>
    <name>I4YB93_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pex19 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_9082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958574.1">
        <property type="nucleotide sequence ID" value="XM_006958512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB93"/>
    <dbReference type="STRING" id="671144.I4YB93"/>
    <dbReference type="GeneID" id="18475845"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9082"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2596806_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB93"/>
    <dbReference type="OMA" id="VIRYEAQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="80" mass="9260" checksum="FC199FA1DE929DC4" modified="2012-09-05" version="1" fragment="single">DDDDDDDNLDSILESVMTELLSKDILYEPLKELSTKYPDYLDNNKPPKLSQEDYDNFKKQHGYVNDVLAIFESDSPNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBB7</accession>
    <name>I4YBB7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_64524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958613.1">
        <property type="nucleotide sequence ID" value="XM_006958551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBB7"/>
    <dbReference type="GeneID" id="18474936"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64524"/>
    <dbReference type="eggNOG" id="ENOG502T0HR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2656348_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBB7"/>
    <dbReference type="OMA" id="NWDMHEK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="76" mass="8044" checksum="EEA2675A2CB3EF6F" modified="2012-09-05" version="1">MSGSPFGIAANAEGGYAVGGKQNLPLGKATVWDKILGNLDYFLATVTRSSDQKQLAKLRKYGGKKAVIGEARSPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBC0</accession>
    <name>I4YBC0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_28903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958615.1">
        <property type="nucleotide sequence ID" value="XM_006958553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBC0"/>
    <dbReference type="GeneID" id="18471065"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28903"/>
    <dbReference type="HOGENOM" id="CLU_1020150_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBC0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="31769" checksum="5F89D7D44CD11315" modified="2012-09-05" version="1">MIDTLSYVITEQKSNVGFICGNLLFGYVVLVMSFWSIIIISTFVVYSDIILQRLVFSSIWFLRGLVTEGIYLKGHKRYRTYNQWISSDIISLKATEKSGMVFVHGSLFWARLFDYETLQYLQAFNVSRLIDDIKTTSIPTEATNQDANSNITRVVKQDSKILVNDIARSKLNTLSERYYTHYLQDLEHYSNNTQDIHRYFDQMVNDNATRIPQEYIYTSHTPQTLSQNILQYFTESLIGYQISSPQATRIPQEIHLRKPYTTNAESKHTAILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL7</accession>
    <name>I4YBL7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958707.1">
        <property type="nucleotide sequence ID" value="XM_006958645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL7"/>
    <dbReference type="GeneID" id="18474016"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60544"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_0_2_1"/>
    <dbReference type="InParanoid" id="I4YBL7"/>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="404" mass="43938" checksum="34CED30399DB632A" modified="2012-09-05" version="1">MAEFDILVIGATGFTAQLVIKHLLEHHKDVKIALAARSLSKLDDVRQKLGVPSDVKSLTVPDLSTDSPELEEIVKTAKVVLSMAGPYALYGMSVATACVRAGVHFVDINGEGPSYYINLVKQLTYKASQTGSILVPSTGLDSLPSDIAVYKSVKGLRDNGIYSDINYSHTSFSGLIKGASGGTISSLLTMYDKTPKDQLRENRRDVWSLAPEVNSERAKLQNGEKLISYDNAVGKWGTPWLLGPHNIRVVYRSAALLPQLYSKTFKYTETLSHESFFRALLRGVMMALGGFLFATFPWFRALLQKVAPKSGTGPTPEQDAACSLVLDNTTKTVDGHEMHTRVTGKGHAGYSLTGIMSSEVALLLAKETPKKEGGVYTPASALGDVLIQELEKYGDFKFTTKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBM1</accession>
    <name>I4YBM1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958710.1">
        <property type="nucleotide sequence ID" value="XM_006958648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBM1"/>
    <dbReference type="GeneID" id="18474019"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60547"/>
    <dbReference type="HOGENOM" id="CLU_1107819_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBM1"/>
    <dbReference type="OMA" id="PFNIDRR"/>
    <dbReference type="OrthoDB" id="3356867at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="27184" checksum="0E32F6A73A173346" modified="2012-09-05" version="1" fragment="single">MILRNLTRNLRYNKPDKLNKVIKLKNNANYSTKLRPAADEEEVILVQRPARFSPKILWACVGTLSLYAVVCAEACYHYESFTPKSDKKEEEDTKTAYWKRILASTSVAFIGLGAGGLLLFNASREVIRLSHFPKSDLLRLHTSLNLPLTVGRGKKLAKLNEGIFVNAKEVSLREPKQSGQRRTLSAVPLALDTPRLPFSIDKRFPWRINVVPPQKPDGFYMDTKSLAGLFKSEWNNLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBR7</accession>
    <name>I4YBR7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958440.1">
        <property type="nucleotide sequence ID" value="XM_006958378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBR7"/>
    <dbReference type="FunCoup" id="I4YBR7">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBR7"/>
    <dbReference type="GeneID" id="18473930"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60411"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="I4YBR7"/>
    <dbReference type="OMA" id="ILFQFPV"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="448" mass="50012" checksum="7299D3D779B76699" modified="2012-09-05" version="1">MPLLFVSYGLQFFDKAAFGNAAVFGLLEDMDLTSERYSNATSVFYWGYITSLLFHPFALQKLPIGKYLSVSILVWGALTVVTIAVHSYPGIMVQRLILGIVEAVVSPGFVILSSMWYKKSEQPIRLAIWYSSTGIFTIFSGALNYGIGSAASKPSSTIEPWKAIYIFAGSWTMLHALIMLFLLPDNPLKARLLTHEERLVAVARIRDNMTGIESKRWKWSHVWECFRDPQVYAYFLLSTAIYMVNGPVTAFGAQIIKSFGYSSLKTILMTMPGGATTALSIWITAWIAMKCRNTRLVLLIISCLPVIVGAAIIWRASWNSRGVPLFGYYLLPIFGAPYVMMLATNTSNVAGATKKKVTASIIFIGYNVGNIASPYLVDTTTASSHYPKAWIGVIVAMCIAILVAALLLVYFILENRRRDQADISEKSINELAFRDMTDIQNRNFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBU3</accession>
    <name>I4YBU3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958465.1">
        <property type="nucleotide sequence ID" value="XM_006958403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBU3"/>
    <dbReference type="GeneID" id="18473941"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60428"/>
    <dbReference type="eggNOG" id="KOG3695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004953_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBU3"/>
    <dbReference type="OMA" id="DHAQEFH"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="639"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="979" mass="110471" checksum="967671AEEA8C6331" modified="2012-09-05" version="1">MELNWQAIQDTLNRPDERQLLRGIQSTEVPKRLSRIVDTLVLETGKYQDIEESPPALDWFLSQDILSKLVNLSAADRPVGIKTEVLKAVSNLCVTMQSHFFVQAPVHKPLVQLLKICTGDNTPNIETSRVLGAASTAATSQPSEYEEHLVDLLCILCNKIKSSPSLLHIFFMDRSWIRYPTRNRRESHEDRPTSPTSMSTVTSRGALSNKSDSEFLLFTYLLRWVHREGRTGDLARAAILLLFEVSTSDNINETEASNIELSSSVDIKAAVAEFIVDGDLAEVLAAGLGAVYGILPTNLAVIPTDPQDKEQKSRSNIVNRLGLVASVELSTSIAFQNQLWVFMSVFEFTAEIIKRGLRSNNKYGIAIAENILASVNDTFFGSVLYPSILECSSMDYSAVAVTTYLEVMLASLNSGPLSEALLDYLLADDDDNKAKEVSDEKPTKKHERRRSTALVLLQSENAAKAKGSSEYFSSLGRFTLKDLITINLRSTNDATAVSTVKLFSQLAYSFDEICLPKLMSIIPKKDATAFPYFHQLHNLMKDYRKREINGKQEGFNEDLLPIPPPMRNVEVNEDELTNYLMLIGSIDAHTTQEMLSTGYERYLDDAQAVIMLHPQYKLATDTENDEPFQAQHKFDLNDKTMNLILDSLRNFFVQSLEMNVSLSGALASLASNPRRSLEGFMTKDWVDEDDPDYDESHPRPDNSLPIVLTIIQDLVDQIDDYRLQAKNNITSQDFDFCLRERRRGMLFKENLEDALALLGDVEPAQRNELVKQFEEGVGRGVLKSRNKRRNQQKKKDYGEIGRISHKRYQDSIDTEFEKRVERNNSWGISNLTAKADKFINKPKTRSATSSLAALFTSNRKKSQSNEVHQQKRQVSAFEGPATPFYDHYRQTEQCLIIPKVTGSTNSKLEDDHMDSIPEDDDKENRADSRDTLLEKVKEIKPVTLSHLLENVVILEEMLKDIVAIIQIRRSIGIDLVCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBX7</accession>
    <name>I4YBX7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958498.1">
        <property type="nucleotide sequence ID" value="XM_006958436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBX7"/>
    <dbReference type="FunCoup" id="I4YBX7">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBX7"/>
    <dbReference type="GeneID" id="18473952"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60450"/>
    <dbReference type="eggNOG" id="KOG2729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112942_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBX7"/>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="136" mass="15810" checksum="33412E1C5ADFDFF9" modified="2012-09-05" version="1">MGLEAWLYLFSVLASAGLLFTMVFFIIMFSDLECDYINPIDLCNKLNNFVLPEAAFHGFLTILFLICGQWLTFIINAPLLGFNIRKTINNNNFYDATEIFRTLSVHKKESFLKLAFYLISFFFYLYKLIVALIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC05</accession>
    <name>I4YC05_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_57547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958526.1">
        <property type="nucleotide sequence ID" value="XM_006958464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC05"/>
    <dbReference type="FunCoup" id="I4YC05">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC05"/>
    <dbReference type="GeneID" id="18472926"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57547"/>
    <dbReference type="eggNOG" id="KOG0481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="I4YC05"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="325"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="728" mass="80750" checksum="89151942DE4AB079" modified="2012-09-05" version="1">MSGFDKGAIYTTAVLPADANSSDRAPSSLERDFSSFINNFRLGDDFIYRDNLRSSLLAKVYALEVSINHLLLYNEDLGYLLSQKPADLLPILEVAVTRIAKTLVNPLQSDTDSIHIPTIQISLKSQSNLVHFRDLNADTVSKLVRIPGIVISASTLSSRAINLHIMCRSCRSTKNLNVSGGWGTINLPRKCDAEVPAGQPKECPIDPYTIVHDKCKYIDQQTVKLQEAPDMVPVGELPRHLLLNLDRYLTAKVVPGSRVIATGIYSTFQASKQKGQAPALRQPYIRVVGLEVDSAHATSGAGGRGKSFTPEEEEEFSKLSQFPNLYERFASSIAPSIYGNLDIKKAVACLLFGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDTVSRDFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPIFGRYDDMKSPGENIDFQTTILSRFDMIFIVKDEHNESRDRTIAKHVMNLHAGRQNEESSAGSEIDLDKMKRYVMFCKSRCAPRLSNEASEKLSSHFVSLRKEVQQVEKDNDERSSIPITVRQLEAIIRISESLAKMRLSTQVHEHDVEEAIRLFKFSTMDAVSAGNVEGMTRGELMDEVHKIEREVRRRLPIGWSTSYSTLVREFCSQQGFSQHALERTLFILDKKEVIRFSNQKKVVIRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC36</accession>
    <name>I4YC36_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_32687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958553.1">
        <property type="nucleotide sequence ID" value="XM_006958491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC36"/>
    <dbReference type="FunCoup" id="I4YC36">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC36"/>
    <dbReference type="GeneID" id="18471541"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32687"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_1"/>
    <dbReference type="InParanoid" id="I4YC36"/>
    <dbReference type="OMA" id="WPMPLPE"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="280"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="447" mass="48769" checksum="9F8EEFF2397C2FCB" modified="2012-09-05" version="1">MSSIIEFQKASANKLKLFYEAPLKIINNLTNVTPETIKTAAGNSVKELQKHDEINTAKVDASQFPHQAAIGANLANFSYSLKKTQRSKLDIKPLEDNPSAEPLNWNTGEIYANAQNLARELMEMPPNYCTPTYFAERAAKEFEGIENIKLQVFDKDWAQSMKMNTFLSVAQGSTEPCKFLQIEYNGSANKEDKPLALVGKGITMDTGGISIKGGAGMDLMRGDCGGACTLLATTQAIAKLKLPINVVFVAPLTENMPSGTATKPGDIITSMSGLTVNVLNTDAEGRLVLADALYYVSTKFDPHTVIDCATLTGAMMIALGEAYSGIFSTTDDLWKLLEDAGLAENDKFWRMPFDDFYLKQINNTAADLANTGGRPAGACTAAIFLKQFVDGINFNAEEGEKPRRQYAHIDIAGSMECTKPESYNTKGMSGRPTRALIEYARRLAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCA0</accession>
    <name>I4YCA0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_64213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958289.1">
        <property type="nucleotide sequence ID" value="XM_006958227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCA0"/>
    <dbReference type="FunCoup" id="I4YCA0">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCA0"/>
    <dbReference type="GeneID" id="18474908"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64213"/>
    <dbReference type="eggNOG" id="KOG1273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032142_2_1_1"/>
    <dbReference type="InParanoid" id="I4YCA0"/>
    <dbReference type="OMA" id="DYEDDIM"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="434" mass="49209" checksum="03477CF5E6F36793" modified="2012-09-05" version="1">MHLPFLSSFHELIIVKYPFANDRPETLEHTLDAGATCIAYNRGGKYTGALLASGRFDGFVNVWDMLTLAPLRVFEGHVKAVSTVSWSKNSRFLLSASRDWNCIVWDMETSERAATIKFDAPIQEAFFHPFTSKFILVTLSTQQTFLVDLTTSKHVKTEIGQLWEEDDEGNTIQRSQMTTARFSTDGQYIFGGTAQGRVIVFELPSLNVVSETGVCNGAIKQISISNSDRLLACTSRDRTVRVAQVSEDKDVQPVFRFVDEIDKTQWNAVCFSNDNEYIIGGSGHKATHYIYIWESTSGALIKVVEGPRDPLHDVIWHPSKPNMASIDSHGQILTWTTNNKQRWAAFAPGFEELEANIQYKEKEDEFDIYVDQDNKPVKEPLEEGLIDIDTIPEEFRVQEVVTPEFIETHFKDEEDNDINFFPSPPDLSDVEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCB8</accession>
    <name>I4YCB8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_57405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958305.1">
        <property type="nucleotide sequence ID" value="XM_006958243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCB8"/>
    <dbReference type="FunCoup" id="I4YCB8">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCB8"/>
    <dbReference type="GeneID" id="18472909"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57405"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019224_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCB8"/>
    <dbReference type="OMA" id="FARAQPQ"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="387" mass="44540" checksum="3B17C1DD7DD9DF91" modified="2012-09-05" version="1">MVVSLLEIVKCNLESKLAGNRTLDVKTLISNFTQIKQQLFPFDNSISNPDIKKILIAFTESETLSSAIEVHLYKLEDKVILYVSKVDSTGFGKTPSPISIAVESIIEWSKLSFKLDIWLHIFARAQNAYIFPNSEKNGKKRVLTDTQLQRWWKRTLDDLKPKSKWLFLPGYTQDEAAGIIKCDNNWIYGNPHQSITDLKDRKLSSLIPYFDDDPKSRFLDELANSTEALDGRALKKPRKENTQEENADYKRNALDRTSIEEFWERLGFRQECASGRVTGFFFLHFKSDDQDTSNENKKDDDYGISIELFHRIHDLLTNSDFISLDSAKVATTSWNDNINSLIDNPKLYISHQVIVNNPEKLKVKENVEAVKPQVLTVRKKKRPASEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCC7</accession>
    <name>I4YCC7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958314.1">
        <property type="nucleotide sequence ID" value="XM_006958252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCC7"/>
    <dbReference type="FunCoup" id="I4YCC7">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCC7"/>
    <dbReference type="GeneID" id="18473903"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60349"/>
    <dbReference type="eggNOG" id="KOG1691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="InParanoid" id="I4YCC7"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697607" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="24747" checksum="921915E810BA5062" modified="2012-09-05" version="1">MRYNLVISFILLSIGFINAVKFDLVATQYPETKCIWHYANANTLVVVTANVNSGSKQRVDIEILDGSNEKYTYLNKKDIKGETRLAITTHQHADIGVCFKNYLTDHVQSHSPIKEASTIDLDIDVGAEAIDYNAIANQEHLSTIETDMRKLEQMTREIVTDMNYLKKREERMRDTNESTNARVKNFGLITLAVLFVLGVWQVIHLRSYFRRKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD2</accession>
    <name>I4YCD2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_54474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958319.1">
        <property type="nucleotide sequence ID" value="XM_006958257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD2"/>
    <dbReference type="FunCoup" id="I4YCD2">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCD2"/>
    <dbReference type="GeneID" id="18472674"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54474"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCD2"/>
    <dbReference type="OMA" id="CNHSSER"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25635" checksum="1C93636962166F32" modified="2012-09-05" version="1">MNLLVEYRSPIPTSPTTTTAPTANIPNTKPLFLCQPFVKAALVKGSFKTIVVLPKHVDVNEWVAINLFDFFHNLNSFYGVISETVTIESNPTMSAGHNFDYTWIDQSRKLVKLPAPTYIDYVMVWVQSLLNDESVFPTKQGNYFPPTFPSSAKHLYKQLFRVFAHLYWSHFTSFVHLSLEGHLNSLFAHFVAFGREFDLIDQRDVVGSGVGELMKVWRDQGTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD15</accession>
    <name>I4YD15_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958159.1">
        <property type="nucleotide sequence ID" value="XM_006958097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD15"/>
    <dbReference type="FunCoup" id="I4YD15">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD15"/>
    <dbReference type="GeneID" id="18473856"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60274"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_1_0_1"/>
    <dbReference type="InParanoid" id="I4YD15"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="6">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="396" mass="44558" checksum="D133F4E95AFAAFD1" modified="2012-09-05" version="1">MTMINIRRDVEDKFYRYKMPQLTIKIEGKGNGIKTVLPNISDISKALSRPPNYPTKFFGFELGAQTTLDEKNDRYILNGAHQVERLREILDSFIAKFVLCGSCKNPETDLQMSKNDDIIKDCKACGKRSSVDMRHRLTTYIQKNPPPKKKKGQGAHAEAANKATEEVEQMENDTQAQDELTARINAEIKDIPVADQRADNEWSVDTSEAAVQARVNQLAEGVTTILGQDGPGSDDDGNDAPESQLALWIEEKHADDENIKPIDIYNKAKDLGIENKHKALQVVVQSAFTENAFKELDAMIPVLSKMSQNGQEKHQKSLLGGLERLVGLNYPELLPQLPKILMKIYQADLLEEAVIQHWGTHVSKKYVDKDVSKKVRVSAKPFLKWLEEAESEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD57</accession>
    <name>I4YD57_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Rck2p</name>
        <name evidence="11" type="ORF">WALSEDRAFT_51287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958197.1">
        <property type="nucleotide sequence ID" value="XM_006958135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD57"/>
    <dbReference type="FunCoup" id="I4YD57">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD57"/>
    <dbReference type="GeneID" id="18472552"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51287"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006421_1_1_1"/>
    <dbReference type="InParanoid" id="I4YD57"/>
    <dbReference type="OMA" id="KQYYYIV"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="67"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="527" mass="60004" checksum="0121C7C000014E65" modified="2012-09-05" version="1">MNDMLSHVPKRLSREEEERKKHAIAQQQKEQREKNRAEEYAREAEMIVEQERKERAKMPSYPGLEQYEIIEKMGDGAFSNVYKALDTKTHRKVAIKVVRKYELSSHQRSNILKEVQIMRAVRHENIIKLITFIDAEKYFHLVLELSEGGELFHQIVKLTYFSEELARHVITQVAEGIRYLHNEAGVVHRDIKPENILFDRIEIFPSKVPQKKPFDEDKVDEGEFRPGIGGGEIGKVKIADFGLSKVVWDQQTMTPCGTVGYTAPEIVKDERYSQSVDMWALGCVLYTILCGFPPFYDESIQVLTEKVAKAQFTFLSPWWDAISDSSKDLISHLLTIDPRKRYTIDEFFAHPWMKGSSTGTAKDKEPTAAPQPTSLDSPMLRDMGGNRKAMASPGVAQLKEAFDVTYAVHRAEEEGRRKGKSSGGGFLGSLNEEDEEEDIQPMSGQISNHRKIAAVNAARQKEAIKKTQNKEAEREKKHVEKLGDNAGKQEKAPKKNFELDLSQATLIDKRRKKGVPQSRSESPMKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD60</accession>
    <name>I4YD60_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PLP-dependent transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958200.1">
        <property type="nucleotide sequence ID" value="XM_006958138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD60"/>
    <dbReference type="STRING" id="671144.I4YD60"/>
    <dbReference type="GeneID" id="18473869"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60297"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="InParanoid" id="I4YD60"/>
    <dbReference type="OMA" id="NPGFNWS"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53638" checksum="460D456FA6B4B7EF" modified="2012-09-05" version="1">MDLEEFRKHGYDAVDRIYNYYKQLQENPGEIAVQPKVKPGYLSTLGDVPPQHGIPFDSIQNEFKDVVLKGLNHWQHPSTFHYFPSNTSFESMITEMTIASINNPGFSWHSNPSSELELVVMDWIAGLFGFSETFYHSKNTSGGGIIQPSSSEGILVAIIAARERILRAENTRDQSKLIIYASTQTHSSAAKAARVFNLQLRILDVDEDLSLRGETVMKAINEDRQNGLVPFVVIATIGTTSTGAIDKIDEIGRVCQSESLYLHIDSAWAGTHLACPELRDELMLDGINEFADSINIGMHKMGLVSMSTVVMFVRDIKSVTDALTITPAYLRNQMTDSGAVLDMKDCGIGLGRHFSSPKLYFMLKSYGVEGFRAHIRKSIGLGERFRRYIEADEVFEVLYKPRLSLTVFRLGGTGDLNSLNRTFYNNLSIHSDKLSLTHTVVNGLYCVRFVTGCPQTREVHVDDAYKIISDVARLTLSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD72</accession>
    <name>I4YD72_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_38039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958209.1">
        <property type="nucleotide sequence ID" value="XM_006958147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD72"/>
    <dbReference type="STRING" id="671144.I4YD72"/>
    <dbReference type="GeneID" id="18472043"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38039"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013818_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD72"/>
    <dbReference type="OMA" id="TCLTHRE"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="117"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="713" mass="78436" checksum="D3CEAC9DDF76CDC9" modified="2012-09-05" version="1">MNELDKYEFPNKSSNHHLDNSPPSPGTSPRQSTQQIPLRSAISSSDRAFLRATGQQPSTSTTKVIPACFNNLNIYDYTDSRRKSVDVGGLARSNKNSKDGLSELIGDLFKKSTHLNEEDEFHFDPSVEIPNKSFLVDKLSTWSFQPLSLTNDDLFNCAIIIVESALTLPSLSQLNLSQFIPFLVAVRKSYSAPNAYHNYTHAIDVLQATYSFLVLLQVAPPISNLNSHEPWQRSQTGLASTLLSDWDVLSLLISAIGHDVGHPGLNNTFMNNAQTPLSEIYQSKSVLENMHCFLLVQLLRKHNLGFLIGASSVSSLSPFDVIDITDDHYDSVETNQLKRASAKAESEVTAMATATPNSPTTPTTSAAPKENKTTHDARKFRNLMSKTVLATDMSLHFDFMKMLTDMRERRLNGKECDEDLDRTLLLQALIKCADISNPARPYHVCEHWSKALLEEWAKQAALETQLSLPVTVFSSADPVSQAKSQVSFIDMFVQPLFQTLSDFLPGMKGVLEHCKKNKERWLSKTEKSESQKTSPPQATQSSPLVMSRNVSISSQGGTISGINSHRSSLSGAAPHHMFSASCCAGSTPLMSPSAEINLQFSRRSSTAKPIAIPSRRSSSISTDDSGIMRQTEAKQFINDVSKPSSTAPASNASVTAFDPRFRQLFPLSLPQALSVNANDGDELGGQLRSVSPGHRQSRYRVSWPASPYSCGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDD2</accession>
    <name>I4YDD2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957784.1">
        <property type="nucleotide sequence ID" value="XM_006957722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDD2"/>
    <dbReference type="STRING" id="671144.I4YDD2"/>
    <dbReference type="GeneID" id="18473747"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60110"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040578_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDD2"/>
    <dbReference type="OMA" id="ENEPMGR"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="112"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="321" mass="35549" checksum="DCF4D5690B9CC957" modified="2012-09-05" version="1">MTILRHLRRMSTRDNYYNNEPEVQPFNDIQGESIPPPAYTPYEQQQHSQQNLYTSPTQTSFPVASIPTSSGYAPPDHPPPRGNSLGGDWLHDARKGLEGRSEDPLLFLSRFDTCFLVDDSGSMAGGLWRSMLSALAGLLEIAINYDPDGIDVYFLNNPATAQNVQNVNNLKSLFDSVQPCGSTPTGTRLEEILLDYLNEYERVTSSGGKMRPLNIIVVTDGTAEDDVETVILNAARRLDGLRAPISQVGIQFIQIGDDPEATVWLHELDNEIHNRDGGCRDIVDTTPAIDIVDGDFDAKYLLKAMLGGINKRYDRANNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL1</accession>
    <name>I4YDL1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_51066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957857.1">
        <property type="nucleotide sequence ID" value="XM_006957795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL1"/>
    <dbReference type="FunCoup" id="I4YDL1">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDL1"/>
    <dbReference type="GeneID" id="18472543"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51066"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_4_1_1"/>
    <dbReference type="InParanoid" id="I4YDL1"/>
    <dbReference type="OMA" id="LCRLCML"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="100"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="342" mass="41676" checksum="2479ADDEEA5E24BA" modified="2012-09-05" version="1">MKWMVHPITSFKMIVITVIAYFNWRKFTPGAFNPFEPLLLLSNPVPRHPEDPEGTVRYAKSYKDILFVLFYVVVFSFTRQFITIYLLRPLAYKLGVRKEAKVLRFLEQAYTFIYFSFSGAIGIWVMYQEPTWWYKTEHFWLGYPHWDMKPHIKLYYLLQTSYWLQQMLVLILGLEKPRKDFNELIMHHIVTLWLVLWSYLINLSMIGNAIFVTMDVSDIFLALAKCFNYVRPGHWVGNFIFGFFILVWSYMRHWLNLRILWSVWYEFDLIPSEARRWWTPDGVWMVDWMKYQIFLPILALQLLNLFWYFLIWRILIRALLYNHLADERSDDEEEEEENDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL2</accession>
    <name>I4YDL2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957858.1">
        <property type="nucleotide sequence ID" value="XM_006957796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL2"/>
    <dbReference type="FunCoup" id="I4YDL2">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDL2"/>
    <dbReference type="GeneID" id="18474867"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63796"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013994_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDL2"/>
    <dbReference type="OMA" id="YGPEFSI"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="110"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="632" mass="71291" checksum="3D2986B4706774C5" modified="2012-09-05" version="1">MVKRAANDRKENASKRTKSTFKKEEEVPSKRKAPITSAAPANEEDSEEDEGYEEVPNESDVEEEVEPSDNNDKAASNKKVHAEQKEKAALRKAQKPHSELVARAKIHWEKVRQNKSMTREERQQHLDPLMEVVTGHVKDVIFKHDASRIIQSIVKWGSRKEREIVAQELEGTYLQLAQDKYANFLLTKLIRYCPTHRSKILASFHGHVPRLLLHKYASGVIEDAFALYANAEDRQALVRDFYGKEFALFNDDESKKGKVLKDLLANESQSKREMMMDNVRNTLQSIFEHSDKGAVSHSIVHRALWEYMSSLEFVYGEVEADKKRKSLLEDCDELLPEIVHTRDGSRAAREFIATLTAKERKVILRTIKPHIEKMATDDQAQFVLFTVLDAVDDTKALSQSVIAPMTKAAEELAFDKNGRRSLHYLTTPRSTKHFTPAFIATIAETDESLKKTSKKDANIRRTEIQKASSADLLKIVEEIPRKLIMDAGGSLILSDIMLYTVGDKCKALDALAGLIETSSDVLDFAPASRVYKTILQGGKFDKNTKKVEVSDPEMAKQAAEKIWKALQAHAVKLAKTSGTFILAELAETAAVHNLSAIKEELLNEFDSPQREEIKNSDAKGNTLLLEKLDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR1</accession>
    <name>I4YDR1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957905.1">
        <property type="nucleotide sequence ID" value="XM_006957843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR1"/>
    <dbReference type="STRING" id="671144.I4YDR1"/>
    <dbReference type="GeneID" id="18475427"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68574"/>
    <dbReference type="eggNOG" id="ENOG502SSBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419327_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDR1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="76188" checksum="6D80E75B18ECB3CF" modified="2012-09-05" version="1">MKLLFNNQLIHNLSKLKNPQRSIESKKVLNDILINKNHKLKPSIYWDLHNLAFKDNVDNQFIKYTLFYISKSDNQNLDFKLNFIRNNFLSIKSELPSIPINIHHEFNNLEINLSLIKWLLTLNDQPSLDLAYNLFKNLNSNNDISLTYKSISIYCHLIAINFGKGRLSIDFLNLLLKQNLSDDTLKLSLIDNLINKFTFDGNQQSMRYLIDYLIKNDFTGFNFDKLFQQLVELNDNVYLLKLYLYSINKYKLEDEKALLQLSNYLTEGNQTSKHKAFILNLFEKDQLSSLSSKVNSKILINLTKLNQLDLITLLFNHLIDKKKFNFLKDSKMISSIVRVFTKSQSVENINFANLVFDYHLNNTKPSDFNHVQLTTLARICLHLNNPTAALEIFRHMLSRNILPDIKDINVVLLLASQDSPKVALNLLNHAISRGLNPSSETYGTLLNAAFQSNDYQLIDNLLVDLESRKIDILPFTQVIVRYFSKIGKNFNHLLLNLDKSDKYRPSKSLLFDLIDDSLEKRVNPHQTSFLLNLMAKYNYLTSSKRHSILLKLIHQYNLFDKFNHHYHRSLLSLIDDQSKFKIPDENSHNMITFIATFSYLNDKVKLFNIFNRLNNLPLSINNIIEILDDMKITVPKSALNVLASNLEQFNRNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR8</accession>
    <name>I4YDR8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_37620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957912.1">
        <property type="nucleotide sequence ID" value="XM_006957850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR8"/>
    <dbReference type="GeneID" id="18472026"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37620"/>
    <dbReference type="eggNOG" id="ENOG502S01H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069193_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDR8"/>
    <dbReference type="OMA" id="HVIRECC"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31436" checksum="6A50CADD1B261DBD" modified="2012-09-05" version="1">MSAFILRGINNKNRSLSQYTKSLIKDTDHRRQLKPPNDFSNLIEKVSKPPIGYTFDQSRRYAPVVLLTAAIETLNSPIGLSKLYEHYISSYDLQNEVDLKKAVHLTQVMRESTLKTITLNGVAKAINCLSALREATPQIIKDNIPQLPSRQLNSNNLEDFRNNGRELWDSIYDPFHDKLIDILNSNHPDMANYILDHHYSALLAAPTKDNPVGRVETSLIAIACLRAQGGVNSQLLSHAFGLEKAGQENYGWLASDIGAKWAIESTDSIVQEFNKSYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU8</accession>
    <name>I4YDU8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957940.1">
        <property type="nucleotide sequence ID" value="XM_006957878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU8"/>
    <dbReference type="FunCoup" id="I4YDU8">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDU8"/>
    <dbReference type="GeneID" id="18471453"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32273"/>
    <dbReference type="eggNOG" id="KOG4672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1144975_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDU8"/>
    <dbReference type="OMA" id="INPMEAY"/>
    <dbReference type="OrthoDB" id="205569at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="27028" checksum="AB6546323C7B9A78" modified="2012-09-05" version="1" fragment="single">GKEAKSSNKSNQLAYTDTFLLEIEIKSLQERSQKEELDKNLSAHFTQLKEEFERIKKAKEEFVEEHPEKKAEIYKHLSAPSAQAQAALARRRDEKPQKPKQLLDKKGMPINPTKSVYYDPVYNPTGVAPPGMPYAEKESDESEEDDDIPMPSALRPDDTNDSVDEDSDLDDIPMPADPPPSTRQPVSASKVAAGPKITQTAEITEADKKQAAASATISSAPQLRDLQKESAIMMPAQLLRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDV9</accession>
    <name>I4YDV9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957951.1">
        <property type="nucleotide sequence ID" value="XM_006957889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDV9"/>
    <dbReference type="FunCoup" id="I4YDV9">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDV9"/>
    <dbReference type="GeneID" id="18473796"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60180"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDV9"/>
    <dbReference type="OMA" id="VKIVNVH"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="337" mass="36752" checksum="997CF9C912D863AE" modified="2012-09-05" version="1">MLVLTKSDVSKVIDEFLNTDDLIDNQRNALISFSKGKVQNPLRSTIKSGNHNLLYMPSSVDHQAIGMKVVAVPLPTASVKVKSDGLPGATIVHDESTGLVEGLVNATELTALRTASSSLLGTSLFVPKSANPRKMVIFSTGKQAYNHAALFYRFYKESIDEITYWNHSSTSLDILNSSMFDFVDTEIIQSVIASSEGKRVDEKLSTADIVICCTPSLVPLFRSDKVKEGAHITLIGSYKPEMQEIDTRLIHDAGDSIIVDSRSDCAEEAGEFIRAGTDLSKVHTLGDLLQDGSSYLKRNGRVSIYKGVGIGIQDSSIARLILDKAKRNDIGTHIDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDX1</accession>
    <name>I4YDX1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957962.1">
        <property type="nucleotide sequence ID" value="XM_006957900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDX1"/>
    <dbReference type="GeneID" id="18473802"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60188"/>
    <dbReference type="HOGENOM" id="CLU_740110_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDX1"/>
    <dbReference type="OMA" id="RHSLNTK"/>
    <dbReference type="OrthoDB" id="3366514at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="374" mass="41476" checksum="C729AB6AD76E347A" modified="2012-09-05" version="1">MSTGSSPLSEPPVRSSTPGQESEASSLLSASEDEMDVDTAKTTKKRPRVVGSSDNEEEEDERGTSKSTGNTNIPLQPKVRTTETSQAKNSKVKVSTSTKFASKEPQRAEEQPKKEVDQAKKLPDIVQERKERQAQVDRQQKEKERQQRKEKEKADSSARAKADRAERNEISKGSTGKTSQDTQEHSVSEAGTPTSKQKSDAPMMKTDSSNADGQQKSSPAVPPASLNTKKDMPSFKKMKPSPSTSGATTPRKPQPKGPMDIGALFNMTEKATDVKGTLAARKEKDEKAKAEEKEIRKKKEEYLKSLDITLEDSSIHSFMDDRDTMTDWEKSLNHKSIPYPFPNNLGMYSIDWIKHGPADFSVDAIKRFNKESPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY1</accession>
    <name>I4YDY1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_57216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957971.1">
        <property type="nucleotide sequence ID" value="XM_006957909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY1"/>
    <dbReference type="FunCoup" id="I4YDY1">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDY1"/>
    <dbReference type="GeneID" id="18472889"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57216"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDY1"/>
    <dbReference type="OMA" id="CTEFKDT"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018026">
        <property type="entry name" value="DNA_repair_Rad4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00605">
        <property type="entry name" value="rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="474"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="526"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="596"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="907" mass="103082" checksum="58FDBAAD50C0C4C3" modified="2012-09-05" version="1">MSSEDDDFEMEEVEVPKASGNDVLVDRIPTNNTVTSSANNATDDDDDEQWEEVDLPGQPTTSTQAPETGIQITITDKSAEKGREKDSETKSRRAGPSPEERAARLASHKIHAVALIANAKHRNKLLNDELLHARMLSLLPLHYQLAFSSLTPSNIPDPIERSRKFDNALKRLIDWWRISFEVDYNLKTLLTTPFADVQEDLKKKRYKGKGKERDKGEMETSNNYEVIRSEKSLQKRALQMRGSRDMSAQLFTALCRALNVPARLVTSVQAVPYRVQSQTASKPVISIDDSSDDPDNGLSKKEKFMTWQQRQKSGFKGDDDAFIRGEAVVANKAPPQIKLTSHYRKSNKRRTNNSSDFSTSSPPVFWTEVFSRPDCRWIVVDPIRNMIRTKARNMMDPQSLYKYNKMTYVVAFEEDGYGKDVTPRYAKQFATRTVKQRPPSKNFDWWDTIVRKIERPYRLARDDTEDAELHQAQFSEPMPQSMQGFKDHPVYVLERHLKREEVVNPPREIGRFKGEIVYPRANVQLLKTSENWLRQGRVVVEGAQPLKRVKQRAVTINKRRVQEAAALAGEEEIMQALYARNQTELYKAPPVVNGMVPKNKFGNVDLYVPSMLPEGAAHLPHKGIAKIAKKLGVDYGEAVTGFEFRQRRANPVISGIVVDASHKDTILDAFDEWQSEQAEKEHDKQLKEVYKQWQKLVQGLRIRERLKEYRGADQQPHERIEEDSENQLQGDSSHYQPGIYEQSLDTITKAKKALPYSRLNEAQDELPTPNGSTTNEGIIDANLEEVPIDDTDENKMDINVPAKIGQPVSLDVLIEQQEQAKQSSSNIRVANGEGYPTRHSKRAREPSSDVATPGTKRVTRSRISNSARDAARKENEEAVKSALGITDEIEDDDDEEEDEVVDISSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE08</accession>
    <name>I4YE08_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_28427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957995.1">
        <property type="nucleotide sequence ID" value="XM_006957933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE08"/>
    <dbReference type="FunCoup" id="I4YE08">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE08"/>
    <dbReference type="GeneID" id="18471041"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28427"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE08"/>
    <dbReference type="OMA" id="MNVKRLM"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="134" mass="15066" checksum="E7AABAB784D35734" modified="2012-09-05" version="1">MVYLLGVNLPDNKLVKIALTRFYGIGLPTSERICAYLSIHDKAKIGQLPEHQMTSLSSFLSAPPALPTTHYLHDFKIEADLRREVRSNIEHHRQIGSYKGRRHGQGLPVRGQNTHSNARTARRVNRLGGRGFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE55</accession>
    <name>I4YE55_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957511.1">
        <property type="nucleotide sequence ID" value="XM_006957449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE55"/>
    <dbReference type="FunCoup" id="I4YE55">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE55"/>
    <dbReference type="GeneID" id="18473658"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59969"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_3_1_1"/>
    <dbReference type="InParanoid" id="I4YE55"/>
    <dbReference type="OMA" id="RHLFHYG"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="142"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="27069" checksum="0D1C16A890A69464" modified="2012-09-05" version="1">MVLRLQTLSRSFRRMKYLTQTEAQNLDKDLMGEEGGFTLQQLMELAGLACAQTVQNLYPAHTHNKVLVAAGSGNQGGDGLVAARHLALFGYKPTLFYPKPSKNEFNQQLETQLKHFNVPRITPEEFDKGVASNDVILDAIFGFSFKGEPRAPFDAPIETLKQTNKPIVSVDIPSAWDVEKGNIDNKSFTPAALISLTAPKLGVKQFTGVHYLGGRFVPPYIAEKYALHLPVYPGGDQVVEIPPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEC1</accession>
    <name>I4YEC1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60009</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957569.1">
        <property type="nucleotide sequence ID" value="XM_006957507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEC1"/>
    <dbReference type="FunCoup" id="I4YEC1">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="18473679"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60009"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_3_1_1"/>
    <dbReference type="InParanoid" id="I4YEC1"/>
    <dbReference type="OMA" id="HFARKEG"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="30"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="695" mass="77067" checksum="CEDDBB3CC6D4B8CB" modified="2012-09-05" version="1">MGGLHNFHPFEISTPHLAYAILGAYVAVFMMFSLFIKERLYIGEAVTSTVFGIIIGPYVGNGLDFRTWGSNDGQADEEITNEIILEVTRIVLALGVFAIGVELPKQYMRKHWKSIFMLIIPIMSFGWVISAAFIYALIPDLTYVSSLTIAATLTPTDPILAAAVIGGKFAQKHVPSHARHLLFAESGCNDGAAFPFLYIGIFLLLSPSDVPYAVEEWFLVTWLYEVALGIFLGALIGYCARKLMKFCEGRNLIDRQSFVAQYVSLTLLTIGIGLILGSDDLLAAFSCGTAFAWDGFFNKATEESHFSSILDLLFNCACFIFIGALAPFDAFNDPSLGGITNWRLVILGLCILLCRRLPIMLALYKWIPDVKTFREACFAGWFGPMGVGAVFIATLAATELPFPEGEPQNQAELVAVTIQPIVWFMVLVSTFIHGLSIPFFSLGRRVNTIRQTTSFGNTLSRASLTEGNDWLHRMRQVVPGQDIVINRDDEAEKGSLTQSSSTQRKESELEGKAAEAQKVLDETSDDPRVQSWIEGNDLVIERPRSDNEDDTEATVFQNVVSDDMREQGRHSIVASVALEIEKEIKDKLLIPISEQAHKSQDIQEGNRKYYAVNHKPGTKESIASKLFQHRKTPPAKPEQSYRPPSSKDSFNDSIDKQTGQSIASPESNSNSAGIRFIDEEDPNRDEPHIHPADKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH8</accession>
    <name>I4YEH8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_37169</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957623.1">
        <property type="nucleotide sequence ID" value="XM_006957561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH8"/>
    <dbReference type="STRING" id="671144.I4YEH8"/>
    <dbReference type="GeneID" id="18472001"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37169"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003540_6_0_1"/>
    <dbReference type="InParanoid" id="I4YEH8"/>
    <dbReference type="OMA" id="SVYYTVC"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="21">
        <location>
            <begin position="190"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM22370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="463" mass="52730" checksum="1363C5DD7CD10F90" modified="2012-09-05" version="1" fragment="single">MEEESDSHSRCPKCPSIDNDQDIADVDDIWIGCEACDNWYHCACVNVDDPEDIEIWYCATCIQNNSNLAIKKKPEPRKSKRSKLKHDYAALNDGITPSYLHVERLPFLQTENYEFKRMKGEDLTIDWLETDPNSLSEPIVVPDPAGLDMKMPASNTSIDHIAKAVGIDKPVEVIDCATQNLSKYPWTLGEWANHYYKRRQAPEIEKTLNVISLEVSDTEFAKEIIPPKFVRDLDWVGNFWPQHKKKDAPRVLLYVLMSLKGSFTDWHVDFAGSSVFYHVLRGSKTFYLSRPNSYNLQQYKMWSESADQGSQWFGDLADTTYKVTLEAGNTLIIPTGWIHAVHTPTDSLVIGGNFVHSYGIEGQQKIVQIEIDTKVPLKFRFPGYQTLCWYVANHYKNTLKDGKKVHERVLSGLTVLGDFLGSLALRIDNPVNENGVADEKALKIAKTYKERFPADDIEIGPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF37</accession>
    <name>I4YF37_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocation protein sec66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957249.1">
        <property type="nucleotide sequence ID" value="XM_006957187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF37"/>
    <dbReference type="FunCoup" id="I4YF37">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF37"/>
    <dbReference type="GeneID" id="18475336"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68040"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_0_1_1"/>
    <dbReference type="InParanoid" id="I4YF37"/>
    <dbReference type="OMA" id="AMSENWG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18803" checksum="48E5EB93A34F3ED2" modified="2012-09-05" version="1">MNSILIPIIYLVLLIVPLSLFSKIYRNSKVKSSIDLISDSWFEPHIERSVYITLLQQENTEEIVLKCALIRRAVEDVKRIWKMRDDKVALVTLIQRGQVGDQLLQQIQAAEKELESEIVEVVSEANTFRMGWGQGIFQSASEIAQHDKMKSTHKSIDSFVLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF70</accession>
    <name>I4YF70_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_68066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957279.1">
        <property type="nucleotide sequence ID" value="XM_006957217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF70"/>
    <dbReference type="FunCoup" id="I4YF70">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF70"/>
    <dbReference type="GeneID" id="18475342"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68066"/>
    <dbReference type="eggNOG" id="KOG1188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037323_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF70"/>
    <dbReference type="OMA" id="YHEKTDK"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="364" mass="40307" checksum="112C1032C8800A55" modified="2012-09-05" version="1">MTLIESSSIKTHGQPTSIQKPHSTSYLTAIQPLETSLAVSSQQNVLLLDRTTFKPRSVIPHQTRVSKLTGCSHDLNAVASADFDGNVWIWDQRMNGEEATSITVKSTKGKKAPIQALDLDTSNHALAAGTELVGEDASVVIWDIRNTSQHMRRYDELHSDDISALKFLPNKHLLTAGTDGLLMYVDPKIEDDNDASLGCVNVGASIANAGQFSDGSIFAFTDMQTAGIYTLDSESELTLQMDLGDIRQRSIENRWESDYIINMSEINNEAVLFAGKTSGEFSMIRDMQTDAMKLERIMKGGHTELVRAVTYDNQLNAIVSVAEDAKIAVWNVQDASDGFRLERPRDDDDEDIEMEENSFKKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFB5</accession>
    <name>I4YFB5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_44299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957322.1">
        <property type="nucleotide sequence ID" value="XM_006957260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFB5"/>
    <dbReference type="FunCoup" id="I4YFB5">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFB5"/>
    <dbReference type="GeneID" id="18472325"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44299"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFB5"/>
    <dbReference type="OMA" id="MQARWPA"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="203"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="549" mass="62466" checksum="109AFB2FC17C9556" modified="2012-09-05" version="1">MQLQYGFRSLKDFKLIENYSNLFELPAEVKVFKYSSCGKYLAYALTDSVVIANSDGSQLAQLDVKQCQDLEFSRKSTYLQTWTRPVRLENNDYSENVEIFTLDGTKVFSTTVKQLESWTINFASDDKWAVKQQSNELLVYDTQNWSKGFTNKLKLEGLVTYTLSPGRNPHLATFIAEKKGAPASLRLYSLLGLSSNSKPVSQKTFFKADRVSMKWNNLGTTLLFQTQTDFDKTNKNYYGESNLYLLSTVGGGYDARITLDKPGPIHDFNWSPNSKEFIVIYGYMPAKATLFDQRGNQTFDFGVNPRNFALFNPQARFILIAGFGNLAGQVDIWDRRTLSKVCQIDCSNTSHCEWSPDGRYILTATCSPRLRVDNGVKLWHLTGKLIHIHPIEELYQVHWKPVDVKSFPEFRNEIEPAPKPHDSVKIYQKPSETKPKITGAYKPPHARGTPSSSGASTPRTRTIPGAAPSPKPPQQRKQKSQDQQQQPEPQAQNDQLTPIDKKVRNLTKKLKAIEELKEKQKRGEKLEKTQLAKLDSEQEINKEIAQLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFD7</accession>
    <name>I4YFD7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_16561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957167.1">
        <property type="nucleotide sequence ID" value="XM_006957105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFD7"/>
    <dbReference type="STRING" id="671144.I4YFD7"/>
    <dbReference type="GeneID" id="18470702"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16561"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_15_7_1"/>
    <dbReference type="InParanoid" id="I4YFD7"/>
    <dbReference type="OMA" id="PAKGCRV"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF64">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="22100" checksum="E4A09C856AF1BF7C" modified="2012-09-05" version="1" fragment="single">MNTPGAGIGASGRDGRTHLFVGNLPYRVRWQDLKDLFRKAGTVLRADVALGLDNRSKGYGNVLMGSEIDAAKAIELYNGYVWQTRTLEVRPDRLPPEYDLPGPQSQPHNQTIRPARTLRALGSSPPANLATASTPSLTNRNIFVGNLPYNMQWQELKDTFRAAGNVIRAEVATNHDGTSKGYGIITFADESEAIQGVQMFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFI7</accession>
    <name>I4YFI7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957390.1">
        <property type="nucleotide sequence ID" value="XM_006957328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFI7"/>
    <dbReference type="GeneID" id="18473622"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59911"/>
    <dbReference type="HOGENOM" id="CLU_1422454_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFI7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="191" mass="21762" checksum="F7C25C5D4572A877" modified="2012-09-05" version="1">MERRQSQGEYPQLVPFEAEWEVIYSNNMETAYRDHACLASNNLAAMYIPRSTLLPISVEQSPTTSSFSDLSWPAFTNSQSSLTNMSQLSSTSASKETPAEQLIQAQKERHRSKINERERISRQGKQSLMQEIKSYLPARGTKRRRITDKEALEWCRDLVVCVNKHDDGCPCKFEPRDGDNAKNDRSSAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFT6</accession>
    <name>I4YFT6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_27553</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956880.1">
        <property type="nucleotide sequence ID" value="XM_006956818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFT6"/>
    <dbReference type="FunCoup" id="I4YFT6">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFT6"/>
    <dbReference type="GeneID" id="18470999"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27553"/>
    <dbReference type="eggNOG" id="ENOG502SGV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080749_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFT6"/>
    <dbReference type="OMA" id="HALHIIT"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="256" mass="29455" checksum="1804D20D638D9C4F" modified="2012-09-05" version="1">MQLVAILKKTLLLALLIFLHLLHLSVQLFKSLKAALRLRKSYNVQAPRTLAVVLILNEYKGLWKRDKQLQWLIDSAKNATRWCENHGVQQLTIYEHTGTLKKYYNDVDVEDTSTDTPPLSPPPTPTLTPQSLGNINKSTVSVRLLSGDEATERFFKVAADVQNEEFSSHTQRIAFTDSLMKRWYKHDDPELIVVHHLQPSFISKCLQVKGFPPWQLRVGEIYHEKYRLPFSRGALSEDVLTRALYSYGKVEQRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFY0</accession>
    <name>I4YFY0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mis6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_56558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956921.1">
        <property type="nucleotide sequence ID" value="XM_006956859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFY0"/>
    <dbReference type="STRING" id="671144.I4YFY0"/>
    <dbReference type="GeneID" id="18472822"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56558"/>
    <dbReference type="eggNOG" id="ENOG502QU9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337139_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFY0"/>
    <dbReference type="OMA" id="RVFKNYY"/>
    <dbReference type="OrthoDB" id="3354477at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="742" mass="85071" checksum="619E284D333BFD87" modified="2012-09-05" version="1">MSSPRDENLDSIYPLLEDLRRHGSSATKEKRDSIKVTFEALESRIGREGCSPEDLTDAIELALSGDLLSGYSIKLFTMLYPLNEVPCRPVQLIVGSLGVQPGKPVDTRVQAAALKWLIIVMDWLDDQARRSLNNLYNALWARLSVESLRPHLPHLIALLTRREHVRPYRVSAVLTLQTRFPLDPSLPGLIQKFRTFYPVRIPPGIGLAAGKRSYRIDEDWKRKAQAIRDGRLEEHEQLVEEEKQRKAGETALPIRERLQIGRKKQRLAYEIPSTTTFDNHSNVITLADCPTVQSVGRNLDRLTLPIQNAALFQSKHMTWAFLANTTDDAIERVEEWLTDLFETIFFDTLITPESYSAGQEILQRVIEFFRYTKELLPIMEDILLLVIKYWDIGLYQNEIFELLSFFPPRTFEAFAKYIIMPLETKSLSAPIDFRIRLVQCYNTIMMRWSAYDWRSMRARRSGIGEIIAEVPDDVNWLSVASQFVDYVENYNTKLLMEYPDNIEIKHLILDSLEASTTFVANVSEFNLRLPDISLIFELLLGGDAGITSRTSGQICYWREVMTIHNELHADGYVGPYPADFLDGFNHMVVNAVEMLYRMKGFTVSDYGEWMGIEDYSIEKIAQEVESVPWKKYKLSLRAVCDIAFSPKFIALTQRFLIELQDVMDIPKKDRYVGPLTNTAIKGSILDNPKLNIRATFLDWLAKKSVTGLPLLLFTSVNSLQYLSQQSGMGSSFYLSQSQSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFZ9</accession>
    <name>I4YFZ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_12231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956841.1">
        <property type="nucleotide sequence ID" value="XM_006956779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFZ9"/>
    <dbReference type="STRING" id="671144.I4YFZ9"/>
    <dbReference type="GeneID" id="18470602"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_12231"/>
    <dbReference type="eggNOG" id="KOG2759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025709_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFZ9"/>
    <dbReference type="OMA" id="QTNELEW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16695" checksum="55032EE09CADB398" modified="2012-09-05" version="1" fragment="single">NLSSRRWNDAELQTDLDTITEQLQSSFASISNWDEYSSELESGLLRWSPVHTDEDFWKNQSGALLKDNNWGLNRLFSLLDSEDQQILHITLYDISQCLKFIHHAKTYVDSSSKQKIMELLQHPDPKIKYQALITTQLLISQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG22</accession>
    <name>I4YG22_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956960.1">
        <property type="nucleotide sequence ID" value="XM_006956898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG22"/>
    <dbReference type="STRING" id="671144.I4YG22"/>
    <dbReference type="GeneID" id="18475300"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67801"/>
    <dbReference type="eggNOG" id="KOG1873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424009_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG22"/>
    <dbReference type="OMA" id="AHEFMRI"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="22"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="756" mass="85358" checksum="917CCADB66E15781" modified="2012-09-05" version="1">MTLENNKNDINNNLKSANDRPVGMRNLTNTCFMNSLLQSIYTLNLLRDVVLRDPNSSAEQDSDLGSNSNNSKSPSQSSSGSPPTFSGVLDTPAIRIWREEGYNDKLRLTCHFFNTLRDFWESKKSPLVPVDILKAMASKFDLYNDFGQQDSHEFLRQLFDAMRMEELDVIYEKHPEYKDAKNKIKKLRPYHYQSVGPTTFVDLLCEGMIVNVIICATCKQIYHVYEPFLDISLALQDENKHPKRRGFRQSVRESILGRPDIKSEELTVEDVVLSDTEDDAQEKESTEQNAEPKKRFSFRNSFSVGSTSRNSQRRTSVLGPLPNSPSPSPHQTHSQLAPSPTGSMFTRRLSKRGKNRRFSRSSAGATSVEDSDESGVRRSKRTIEDKVYTQKLFGDLTTPSTPQSTHSASMTELANEQTMTSPSSTPSSFRDGQSIQAANSQSSVLAALRQPPPPQSNDSSLPSSAPMSATPSSNIPKTGIEDAFERYAGIETLQNENEFHCHGCWKQQNEVQVEMIRRFKDSKRKESHKSVLGVTGMTPLKDEVKEPDTYQAESDVDEDSDAEDDDDITEKDWNAFYGDTVAYVPRKQQVLGSKALRRTLIAIAPPILVLHLKRFGSVGGFALSKIFDNINFPLDLDIGPYIAPEKPKEGRNDDLSGDDVDPTTTEDYKRLAEMAFPTASTKYRLRSTVNHCGRTMISGHYTAFTSREVQVEDEKIQLQWYWASDETIKPKTEEQFLHESFKNDDQNAYVLVYERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG46</accession>
    <name>I4YG46_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956983.1">
        <property type="nucleotide sequence ID" value="XM_006956921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG46"/>
    <dbReference type="GeneID" id="18471338"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31617"/>
    <dbReference type="HOGENOM" id="CLU_1504607_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG46"/>
    <dbReference type="OMA" id="WELNADM"/>
    <dbReference type="OrthoDB" id="3356802at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012949139" evidence="1">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="19022" checksum="1F1A5F934CA8540F" modified="2012-09-05" version="1">MKFSAIAMLAAVASAAPILKRDVPIVSFEDAVASNKNINLVTSDATLPIGWNNDVLTTDQEPITVNFIPASSTFMKYTSDDNTKYGHIVDTATDLHLTVSSPGKASGQTIYSSEGSSSDDSGQMLQFWALDVNSQQVRFLGAPQGADFGEGPFYPESQNEGNGLEVVLTTDQVANLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG55</accession>
    <name>I4YG55_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956992.1">
        <property type="nucleotide sequence ID" value="XM_006956930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG55"/>
    <dbReference type="FunCoup" id="I4YG55">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="GeneID" id="18475305"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67831"/>
    <dbReference type="HOGENOM" id="CLU_1416175_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG55"/>
    <dbReference type="OMA" id="FTHIDPP"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21926" checksum="5EAB65A4E177B658" modified="2012-09-05" version="1">MSLIRQRKDYLNKLYKNLLEQQNLLFLQFNNFNVKELNQLRSRLGELDSNLTVIRSGVFRGLTEDIKLKNLLNGNICLISFNELNPANLKKVLTQVDTIKSNSRFKAMPLTNQSTDTVAVNPKLTLLGGHINNQTVDIFTIRQLANLPTLEQIHAQIYSLITTPSSRIHSHIQHPSQHLSLLLKSHSNHQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG84</accession>
    <name>I4YG84_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial NAD transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_53776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957017.1">
        <property type="nucleotide sequence ID" value="XM_006956955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG84"/>
    <dbReference type="FunCoup" id="I4YG84">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG84"/>
    <dbReference type="GeneID" id="18472630"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53776"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="I4YG84"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="296" mass="32932" checksum="352924E26ED6F876" modified="2012-09-05" version="1" fragment="single">MASSWRLHDSTIAGGVAGVVASVVTCPLDVIKTKLQAQKKFKGRTLDGVIGTIKRISKEQGFKGFYKGLGPTIFGYLPTWAIYFTVYDEVKAVLSKSGDPNGVNWSTHMIASATAGATGATLSNPLWVVKTRFMTQDMESIPYKHTFHALKCIYKVEGLKALYKGLIPSLVGVSHVVIQFPLYERLKFKMKSNDNNELTTLQLLSCSSISKMMASISTYPHEVVRTRLQIDRNRDKHHLNSSEILKVIRAIMNESGLKGLYKGLSVTLLRTVPNSAMTLLAYEVIMSDLTRRRIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGD6</accession>
    <name>I4YGD6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957065.1">
        <property type="nucleotide sequence ID" value="XM_006957003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGD6"/>
    <dbReference type="STRING" id="671144.I4YGD6"/>
    <dbReference type="GeneID" id="18471349"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31669"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_8_2_1"/>
    <dbReference type="InParanoid" id="I4YGD6"/>
    <dbReference type="OMA" id="PTKFCVG"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF162">
        <property type="entry name" value="RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="145" mass="15783" checksum="6E739422605ED219" modified="2012-09-05" version="1">MIALEEANKAPIAQGAFSVGCVLTHQNEILSTGYSRELEGNTHAEANAIAKVQDKSILSQVELYTTLEPCTVRTSGLRACTDTIIEYGIKKVFIGVEEPPDFVNCQGVSKLKEAGVDVIFLSSEEYTRQTGRNLSEDCLIAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGJ2</accession>
    <name>I4YGJ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_67946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957117.1">
        <property type="nucleotide sequence ID" value="XM_006957055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGJ2"/>
    <dbReference type="STRING" id="671144.I4YGJ2"/>
    <dbReference type="GeneID" id="18475320"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67946"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_9_1"/>
    <dbReference type="InParanoid" id="I4YGJ2"/>
    <dbReference type="OMA" id="HEDASQN"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16635" checksum="73EB89AAD0ACF66A" modified="2012-09-05" version="1">MSSIFCNQPKDFGFPIEFLIEEAAPKKHINSTLSTHKPHLDLLEYENSYEARLNLAGYKKEELDISIHSHKITVKATHPTEENQDNKFSYLINECRSSPTVSRTWKIPEHVTEDNVHASYTDGLLTLRYSRHAPESEPKRININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM6</accession>
    <name>I4YGM6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956519.1">
        <property type="nucleotide sequence ID" value="XM_006956457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM6"/>
    <dbReference type="STRING" id="671144.I4YGM6"/>
    <dbReference type="GeneID" id="18473355"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59436"/>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_1"/>
    <dbReference type="InParanoid" id="I4YGM6"/>
    <dbReference type="OMA" id="CSQPEVI"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="341" mass="37273" checksum="4C7022B08A465A57" modified="2012-09-05" version="1">MPELEILDGGGATQLETYNLDLTGSLWSASALNDNPDLVEQMHRDYLEAGADIIETCTYQVSLEGFKTKEATSSAVQKGVQIANNAINTHNEVDHSSQKQLAYALGPFAVATADGAEYTGEYSVDYSLSQGSLYSENLKQFHLGRLKVLNTQAKVDILLFETVPLLSEVRAIRAAVEEYRAYVKSSVPLYISLVFPDGSLPGSKILSEGPSGIKDIIETIFGGNSAEVDAIGINCTKPHYLRRLVSDIVDHLSSYELNRKPKLMIYPDGGLVWDGKERVWRQPEHSHHADSSWAETVADAASIVANDAFSPFSGVIVGGYCKSGPKEIKQLRSICQTRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGP1</accession>
    <name>I4YGP1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_15161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956495.1">
        <property type="nucleotide sequence ID" value="XM_006956433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGP1"/>
    <dbReference type="FunCoup" id="I4YGP1">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGP1"/>
    <dbReference type="GeneID" id="18470650"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15161"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010392_1_0_1"/>
    <dbReference type="InParanoid" id="I4YGP1"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="637" mass="70024" checksum="48DC0A462BC14BB5" modified="2012-09-05" version="1">MNYIYQLTQAATTAVLEKSGRNLPFTIGKATGKHSIWDTFDGVKRDDNSSLTIFVYNKQINQRYTQLANNALRKLRTLRHPQILKYVDAIETDTMIYIATERATPLSTFLPSDDTIWLTWGLQNISQALSFLHTLTNSIHGAVSSDSIFISESGEWKLGGFELATSQSELSNGILEGNYDRKTAAPEARQGFDAISSNPVSSLDSYSFALLISQLYNPTKPLPLDLTSAPPPSSKGMIPTSLFNAYKKLLHPSPKSRLSVDGFLQLGNNSQDTQNGAFFTQNPLIELCQGLEVFSLMRQAERVVFLKNLSQLLNYDNSSGNILGERKVSIPNSLAIHRILPTLVHSVEFMTAGDSAPSLVPLIVRIGMRLDTEDERSKAISKPLLRLWMSPDRGTRMALLEDLERYIDVLSNKIVVNELWPQLITGFNDTAAVLREATIKAVPLISSKLSDRILNNELLKQLAKAQLDPEPSIRTNTCILIGKLTPKLALATRKKVLVSACARAMKDSFAPARAAGLRTLLATVDDQEENDLATRVLPTICPCLLDKEKSVRDQAFDVLRSIIARVESIASKMPETAIKADSEIDYSYSGTAGKSFLGDDQLGNAASAIAGWAFGTSTTTKKVSSNDITFTKANEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGV4</accession>
    <name>I4YGV4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956590.1">
        <property type="nucleotide sequence ID" value="XM_006956528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGV4"/>
    <dbReference type="STRING" id="671144.I4YGV4"/>
    <dbReference type="GeneID" id="18473381"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59485"/>
    <dbReference type="eggNOG" id="ENOG502SE84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720035_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGV4"/>
    <dbReference type="OMA" id="WCEDRSS"/>
    <dbReference type="OrthoDB" id="2595549at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="384" mass="43873" checksum="E4BF86286CE6E740" modified="2012-09-05" version="1">MATSHSRRKGNDSAKRCIDLIESLPNMLPPKITDIYRPVKRNRLTNDTPKSSNNSFTSNASTPRIEINKKDSNRKWSNQDYKETSSLYKERGRNIKHWGDRHYQLSTKATGDESDYLRVLAACELLDAVLMYAYAFWCEDRINGTLLQNWNSLEPLAKFSRSKCDSLTVNSLVNRTLIDQLQGLALMLYGLVLFQISTIESTQSYHKSLKLQKAPSSDVNEMQQRTNELLVRNIENHKRKDKAAEMLDKSRLKFPSYNLRVKFPRTWARAVGGMIETENDDDSEEYEELENDAQRASELGVSSHLVQRVKIGTVDGERLDPDNILGPGGSSGGGFAWPLLEGGFSHDWWPHIVVFSRSILDEFGQIVRLHDFHTGDKRGYDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH59</accession>
    <name>I4YH59_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rsm22-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956688.1">
        <property type="nucleotide sequence ID" value="XM_006956626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH59"/>
    <dbReference type="FunCoup" id="I4YH59">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH59"/>
    <dbReference type="GeneID" id="18473419"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59550"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019579_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH59"/>
    <dbReference type="OMA" id="IMRMTIP"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="673" mass="77073" checksum="3050BA4053525E94" modified="2012-09-05" version="1">MLRRSCLRIESSKRFIHSTRQINLINQEDELKKLSKDIELHMNSPTNDLSNVVHPGLWENAERIDTNSPAYKFGKFAAGQIVIPASVDSRLTDKLNKIDKAELRQQARSIYKLLEPKKNLPPKKIPRFIAYTRPDQPLAYALAIGPGVYAAVYSVMREIRRRASSEVDGWLPHRVIELGSGAGVSAWATMDAFKFGSNSSSLHSEEFEGNDETSITNENDEDELSSLHSVLTYDAFDPSEEMNEFNKQLWKDANRSTQLNVSRKFISSRFKSEDPIESSKTLALSTFTLSELGSLADRRELIHRLWKSNAEIIVIIDRGTKEGYERVMEARQQLLDLGAVSDTKSHVLAPCPHDGQCPLLQTKDFCHFSQRLQRPAYQRYIKKAKLGTEDQKYSFVVVRRGSRPKSDNDKTLNQLSKYSASELIKLQSLEGRKNLEVIDKIENDHQVTDRTDEIECTDEAIDRNLNDNVITTTQSPYSTNQLDIQSNLIDSPQYDNRELLLRDSFNWSRVIYQPLKRKGHVIFDTCSNRERIERFIITKRDGDSAYRDSRKAKWGDLFPHEPNGNIQIKSNGIKRTSSIQPDIIDSDGSMDNKVNNDAAYMDSNNKLIINPYDHDQAHKDRTIKRRVRGIGSARKLRKGKGARMADLMEKKMVDEKLDKIAREATDEIMKNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP2</accession>
    <name>I4YHP2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_42623</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956162.1">
        <property type="nucleotide sequence ID" value="XM_006956100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP2"/>
    <dbReference type="FunCoup" id="I4YHP2">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP2"/>
    <dbReference type="GeneID" id="18472256"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42623"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHP2"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="263" mass="29404" checksum="2BEA946E3DAC9435" modified="2012-09-05" version="1">MVAKQHPFIRGLSELVPHPSPLLSVSQDKPEDWFDFKQPSLWIVIASIVFNPLFWNIVARQEYHNKLLTKLAGGRPYLGCYLLAVTIFSLGILRDHLFQSALAEQPNLAPHPYYPTAHVYIALALFLSGQILVITSMLALGVTGTYLGDYFGILMSHRVTSFPFNVVEDPMYIGSTLCFFGTSIWYRSPAGIAISVFVFIVYQIALRYEGPFTAMIYSAKDKKTEEASPKAAPVKAPVEPVESSPNNSPAYRTRSRARKVIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS9</accession>
    <name>I4YHS9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_67179</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956198.1">
        <property type="nucleotide sequence ID" value="XM_006956136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS9"/>
    <dbReference type="FunCoup" id="I4YHS9">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHS9"/>
    <dbReference type="GeneID" id="18475217"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67179"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021971_0_2_1"/>
    <dbReference type="InParanoid" id="I4YHS9"/>
    <dbReference type="OMA" id="EMNNGEG"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="253"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="489"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="531" mass="60036" checksum="0C7E10786C8DDA2D" modified="2012-09-05" version="1">MSTNNLKREASNQAAKPNNKRAKNSRQRSDKRATKQPGQPLDDRREWTREWAGLPKSSDITQSGPKLPKRKCAVIIGFCGTGYNGMQIQPHGNVKTIEGDIFVAMIKAGVISPDNSTDPGKVNLQRAARTDASVHAAFNVISLKMIVDLPDTPDIVEKINEHLPNHIRIWGFVRTQNSFDARTSCDSRSYEYLLPSYVFIPPSPWSNLGKRLKSSHPFWEGVDETEDIASMMTRKRAYRIDSDTLDRARETLAQFEGSHNFWSYTIGKGFRDRSSQRFMKKLTIQDPFLVEGNEWISVRFYGQSFMLHQIRKMIFMLVNVVRTGTPASLIPTTYTDLPIVVPKAPGLGLLLEKPHFNVYNSRVKENNEHIDQNAGERINKAVEKVHKQKGKDAEAGKTDVEYPSDEQIKSETTKQINGDRRELIDFVPYEEKVEAFKHEYIYKRLRKEEVLGNVYSRWVGMIDSHEGQQLDYLNPEGVITESAIKAGKKGVKGGQNAQLDGADNSGVKATLESDDEDNYDKKALKSGELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT7</accession>
    <name>I4YHT7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_42693</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956206.1">
        <property type="nucleotide sequence ID" value="XM_006956144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT7"/>
    <dbReference type="FunCoup" id="I4YHT7">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHT7"/>
    <dbReference type="GeneID" id="18472259"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42693"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="InParanoid" id="I4YHT7"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="38"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="47374" checksum="4EEB6D271BFDC52A" modified="2012-09-05" version="1">MPDQSEFQVVENQTNLTQKNANNPYAGVDSFLSNVSNFQIIESTLREGEQFANAFFDTETKIKIAKALDAFGVDYIELTSPTASEQSRKDCEAICKLGLKSKILTHIRCHMDDARVAVETGVDGVDVVIGTSSFLREFSHGKDMAYITKSAIEVIEFVKSKGIEIRFSSEDSFRSDIVDLLSIYRTVDRIGVNRVGVADTVGCASPRQVYDLVRTLRGVVSCDIETHFHNDTGCAIANAYAALEAGATHIDTSVLGIGERNGITPLGGLMARMYASDPEYVKAKYNLPALREIENLVAKEVEVNIPFNNYITGFSAFTHKAGIHAKAILNNPTTYEILKPEDFGMTRYVSIGHRLTGWNAVKSRVDQLNLPLSDDQVKDATQKIKQLADVKSQMSMDDVDNILRVYHASIEAGEPGQSPEFQKLLERAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI63</accession>
    <name>I4YI63_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_42838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956323.1">
        <property type="nucleotide sequence ID" value="XM_006956261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI63"/>
    <dbReference type="STRING" id="671144.I4YI63"/>
    <dbReference type="GeneID" id="18472268"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42838"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="InParanoid" id="I4YI63"/>
    <dbReference type="OMA" id="MCVNGFM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="624" mass="70170" checksum="1E2806662AF50F27" modified="2012-09-05" version="1">MREKHKLSWSDLGFKTNGKKSKTILSEQNGTIYSGEMMAVLGPSGAGKSTFLDVISKKAKGSPGTIISFNDDPKFDMRELAQYVEQDDALIGVLSVRETIEFAAKLSLPTNITRGELLKRVDVTMKSLGISEIANNRIGTPIQRGISGGQKRRVTIACAVVSHPRILFLDEPTSGLDSQTSQEVMQSIKQLAVEQGIIVLCTIHQPKWEIFQMFDQCLLLASGKTMYQAPTIELINYFDYLGKPCPAYTNPADHAISLVNTDFSNKNPGFDSEKYLTGLSQKWKSYSRNGSGSTAELKDDYTDMKTPRTPAESLFTNKSNSPSTMIMRSRTSDFYNWCYKVTVLCHRSQLNSQRNLLAYTARMAMYIMMGLLIATVWLHLGTSSDKINERLSIHSFGVTFIAFMSVSGIPSFLEERMVYVRERANGLYGPSAFLISSTLITIPFVFVCCSLFLLIVYWAVDLKPGADTWFRFLAYYFLTSFVAECQSVLIAALIPDNVAAISLGSFINGFWMCVQGYFIRTPNLPKFYYYFVHWISFQTYGFVLNTKNDLEDVLFSCTQSSEGQCQCSYPSSLQQKGICALPGEDILEYLEIKDKNKVLFAFAMLIIAVVYRLLFYLVIRMTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIB6</accession>
    <name>I4YIB6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_62375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956373.1">
        <property type="nucleotide sequence ID" value="XM_006956311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIB6"/>
    <dbReference type="STRING" id="671144.I4YIB6"/>
    <dbReference type="GeneID" id="18474743"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62375"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_1_2_1"/>
    <dbReference type="InParanoid" id="I4YIB6"/>
    <dbReference type="OMA" id="VKTWSSY"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="271" mass="30550" checksum="0254BF7B8F899028" modified="2012-09-05" version="1">MSRFSHANFNAKNYAEARPTYVPKIYDLISNFHKGARDAVVDVGSGPGNGTQGLLDLDFGKVYAVEPSTVMIEEGKNRPRGTEIDWFTGSGENLSQILPNKVDMITSFEAAHWMDHEKTWKECYEVLTPGGTVAHVMYGHTELLGNEKASEIVLDFARNKLKAYYMPQHDIAFGLMDAIDPPSWATRVERHKFLTKSKDGENQCIMTRETTLRGLQAQIYSWSPTDQYVEEHPGEDPVGDIMKVIMELYNAKDLDHPITMAWSLAVFLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIF3</accession>
    <name>I4YIF3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956410.1">
        <property type="nucleotide sequence ID" value="XM_006956348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIF3"/>
    <dbReference type="GeneID" id="18473322"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59379"/>
    <dbReference type="HOGENOM" id="CLU_1961293_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIF3"/>
    <dbReference type="OMA" id="HMSNSYI"/>
    <dbReference type="OrthoDB" id="10559600at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="128" mass="14031" checksum="6707B9ADE14F230D" modified="2012-09-05" version="1">MPGVTKRASEINLRRKSKSSLNQRRRLKAAASSERINDENNGELATGSNAKKSKLNGGRRALLEIAWWTVTPNLSDYLENNNNNASNSYILYSSGSSPSDNNNIDNQQPAKGGLAPPRPTPSRMSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL3</accession>
    <name>I4YIL3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956468.1">
        <property type="nucleotide sequence ID" value="XM_006956406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIL3"/>
    <dbReference type="GeneID" id="18473346"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59423"/>
    <dbReference type="eggNOG" id="ENOG502S5UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043860_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIL3"/>
    <dbReference type="OMA" id="IMELDFN"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="316" mass="35549" checksum="D955AB32D9589957" modified="2012-09-05" version="1">MADLVNIIKEYTPVLLSISKYAVVALIALNMNSFPLVWHFRTFGCVYWHKWFGNHERSVGIDPFKTVSTRKYIATIDDCDAFGFHLSNSSYAKNLDSARLDAWVELNYRLFKEAQVWTPLGASSYYFVKEIPFGKKYEIRTSIGAFEQDKWFYYVSKFVSKKSKKSKGSTSTPANLATAGSHATAPDTVSGTATPIAKDESPNSLIAQAYNELSPDEELNCIAITQYCFKSGRLTVPPPIALGLAGLGKNGEKNHEIFKKLVKEHKLKAYLRGGYKKDNPDFADVELNINDLEITNSTRFEPYRAFTNALTSFKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ57</accession>
    <name>I4YJ57_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_30783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955833.1">
        <property type="nucleotide sequence ID" value="XM_006955771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ57"/>
    <dbReference type="FunCoup" id="I4YJ57">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ57"/>
    <dbReference type="GeneID" id="18471180"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30783"/>
    <dbReference type="eggNOG" id="KOG0173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="InParanoid" id="I4YJ57"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="11">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="29644" checksum="0165B970197EDB6E" modified="2012-09-05" version="1">MVAEFDFSNFNRNNELASKNPSNLPKATSTGTTIVGCIYNNGLVLGADTRATEGEIIADKNCEKIHYLTDDIRCCGAGTAADTEAVTALISSNLELHSLSTNRKPRVVTAMTMLKQMLFQYQGHIGAALVLGGIDSTGPNLFTVAPHGSTDKLPYVTMGSGSLAAMAVFEAEWKPQMTESEAKDLVIKAISAGIFNDLGSGSNCDVCVIDQDKPTEMIRNIKPELNARSIKERNYKFRKGTTAFTKQSIRDFVQEEEVIEFNKQPEEMDLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA5</accession>
    <name>I4YJA5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L33-A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_30811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955877.1">
        <property type="nucleotide sequence ID" value="XM_006955815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA5"/>
    <dbReference type="FunCoup" id="I4YJA5">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJA5"/>
    <dbReference type="GeneID" id="18471191"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30811"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJA5"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="104" mass="11651" checksum="EA8420A80928E68C" modified="2012-09-05" version="1">MTRLYARGRVLSHQRGKRITHPKTSLIQIEGAQKIEDAKFYLGKRIAYVYKGKKAVNGSKVRVIWGKCTRTHGNSGAVRAKFASNLPPRTFGASCRIMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL0</accession>
    <name>I4YJL0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955976.1">
        <property type="nucleotide sequence ID" value="XM_006955914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL0"/>
    <dbReference type="FunCoup" id="I4YJL0">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJL0"/>
    <dbReference type="GeneID" id="18473183"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59119"/>
    <dbReference type="eggNOG" id="KOG2393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547690_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJL0"/>
    <dbReference type="OMA" id="VTCGKTM"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="498" mass="57960" checksum="B6A59E7778BFD86F" modified="2012-09-05" version="1">MRLNSNSSVDPANFSRPVKLNRKDPNHLLRPVPDIDPNTGKVKLDEQDRPILIDPQTNQVIPPINDKNKRFFKRKTKQVFMADEDAMQLRRTERLPWILEDSDGSQKWHGQLDGKPSDQSYIMLVFNENHGLDFKVQPTNRFYKFNQQPKYDTLSMEEADQAYSKGVDDVWFMRNRSRPVASTSNQSDPEIDNKQSIHQRLEGMMNQQPAQSRQANRRMQVDRGAVKEETFDGLFDEMEYDEEFQDDDEQVIQDNQDDDELKELEDRIKKEMHQANIGHVEQTTNLDDFEEDIKPFKQKSTSEKEMKKFLRRYDKSNADAYESDNSDDDDDEEEEERKKQEQDREQQRREREKKEQQDKDQATNLAKSIKREQSPASLAAHEVARRATSPYAKQRSSSPSTKRSRTDLEDKPDNKKLKVKRESSSPSATPPNSADGQVLQDDEIIAFLRGKSVTTNELIQHFKKRFKAQPKNRETIGGVLKKVASRTPDGKLQLKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL9</accession>
    <name>I4YJL9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955983.1">
        <property type="nucleotide sequence ID" value="XM_006955921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL9"/>
    <dbReference type="STRING" id="671144.I4YJL9"/>
    <dbReference type="GeneID" id="18473185"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59123"/>
    <dbReference type="HOGENOM" id="CLU_991113_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJL9"/>
    <dbReference type="OrthoDB" id="4670611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698091" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32690" checksum="77B6197E6EEFD96A" modified="2012-09-05" version="1">MLKKVLLVSAALTGTVVNATTYATFYSDPECKNDASVDFSVNNPGCFSAGGNEYVKYHGTNAQCFSLVKSPSPSCPCQFDCITGPNSVGSTISGCGPPIIPDSGCHHIGQAESLRFIGGTCGLSNCPDRSSRSIPVLEEYQDTEEIVEEKGSKENQEEKGEELVKQKSERESQESAKEAETELVSKYNNGVTPALDRRDYGKPGLGYYRFCKDEYCTLDCSINFRTTNTGCIAGDGFKSIQFLGSVSSDTNLRLVHTPHGECSCQDDCWHISGNECMVLPEAQQGAGSYRMITESTCDVNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM0</accession>
    <name>I4YJM0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_13943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955658.1">
        <property type="nucleotide sequence ID" value="XM_006955596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM0"/>
    <dbReference type="FunCoup" id="I4YJM0">
        <property type="interactions" value="860"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJM0"/>
    <dbReference type="GeneID" id="18470622"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13943"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJM0"/>
    <dbReference type="OMA" id="KPVYFQL"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="886" mass="101208" checksum="90AF316F50F38D9C" modified="2012-09-05" version="1">MTTTIQKVIESLNILYFNENNNLKNLANTFLQEFQSLTDAWDISNQLLITNDLPLEIKLFSIQTLRSKIIYDFNQLNDQLRLELKINLFDQLKLQSNNLLIKHLNLTLADLALQFDNWLDPIQDYLNEFGQSNHSILLDFLSTLPEESNNNKLSLSIDQLESRTYALLTNKSSDILQLLSNYSLRSDINLDLLFDCIKSWSFAGEFTPLMLNSTPLLDLLFNSLSNEQLFDKSIDTLSVIIHETQEIHENLTVINIILGNLTNLIDKLHSSIQQNDDDTVRNYTRLYSEAGETYLPLFLSNFDQMEPIINSILLCSKYNDLEIVQITFNFWFKLAHALDVKPHLKSQFIPIYSQLIDIIIDHLKFPLDESLQSAQERDEFRSFRHYIGDTLKDCCTVIGPKKSISRSLELILQGISTNSWQYVEAPLFSLRSMGSKVDYENDNDSLESIFNLLPNLPEHPRIRYAGILVASRFTEWINKRPDFIPFYLSFISTGFESNVPDVDIPAAACQALKFICEDCNHHLISYLPQLFQFVQQLTDTKLHEQDHLNISQAIAFVIETIEPKNDQAVIINQFVSPYLVHINDFFSKTESTVNKDDIKSLISNIEQIESYIAFTGPLSPLPVECQSTPFEVYNLLVKVIVNFGGSHSLIERVCGLLRKGLRFFDESAVLPIIPNLLEVLVNAFGSNPLSAYIWLIGKCFNLIPKEKTMISTSFNNISNKLFTILQSKQPSQVPDLIEDYIHLLLQIMDYEPSLIFNDNVIQPIFDLSLTGLNLYNPEAILVSLDFIRDFVDVINDNNSNSNINKTVIAKTLSNHTNIANLIQILLEGLVNSFPEDCVSTVITLIRQLAQFNNNLMKEAIPVVMNQSSLTSVAVTDQQIFIESYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJS9</accession>
    <name>I4YJS9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956039.1">
        <property type="nucleotide sequence ID" value="XM_006955977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJS9"/>
    <dbReference type="GeneID" id="18473199"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59153"/>
    <dbReference type="HOGENOM" id="CLU_2689696_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJS9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="74" mass="8253" checksum="87FB07B1A0E51CFB" modified="2012-09-05" version="1">MQLEYNPHASVVQAHLSHTVAHRRPSVGEHGEGKSPKRPTIDTHMANKPSEHIQRRESQINTAAMVAYLSNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJU0</accession>
    <name>I4YJU0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_53254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956050.1">
        <property type="nucleotide sequence ID" value="XM_006955988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJU0"/>
    <dbReference type="GeneID" id="18472609"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53254"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJU0"/>
    <dbReference type="OMA" id="IPFLMIW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="507" mass="56346" checksum="C13C74125D693B10" modified="2012-09-05" version="1">MSLKHPQEADDGCLHLNEKLALETKSENDLSANPIKLAPYLTGSEYSTESLEDTKSVPQADTSVHDAHYKRALRKIDVRVILILSISSFLLCITRTSFPNALVMNDDDENGSMKDQLDITDKRYSYIVMILTAVSIVFELPSNLLLKYISPRFHITRLAIGWGIVTICGAAATNFQGIVANKIFLAIAQAGFFPSVFYIFGLWYTEEQKAFRVAIYFNGLILSGAFSGLIGTACSYLNNKGHLTGWRWLFILTGIPSVLIGIVTFFLLPNNPETATFLSEEERDVIIKGLKVSQIKNTSSDASNESTKLSFNDIWIVFKDSTFWFLTIMYILMVMASIPVSQFLPLLIEDLGFHGVNIQLMTIPVSIFTLICSMISGWGSDRFRNRPLFIIIGLSLVAIGYLMLGLIKTNIAGRMIALYLTSLGPVSEIPMVVYVLKLQQDKGWSSSSFKFGSSAILALASAGGITAPLVMESGLTKENVSYAFFAFTMFSTTDYERYKPSYVIYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJY7</accession>
    <name>I4YJY7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956093.1">
        <property type="nucleotide sequence ID" value="XM_006956031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJY7"/>
    <dbReference type="STRING" id="671144.I4YJY7"/>
    <dbReference type="GeneID" id="18473215"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59186"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157169_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJY7"/>
    <dbReference type="OMA" id="PCAVKLF"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="27103" checksum="19C41CF217BB2D19" modified="2012-09-05" version="1">MVSQELQTYCSTSYGSLAAVSGSTKERYQAGKVLARDMANYVISLFDCPVNKSIIPLADFIHYALYRTRLDVSVALSSMILLQRLKSRYPNAKGSSGHRLWLAAIMITNKMFNDDSFTNQSWYIASQEIFSQREVNAVERELFGYLSCDVRVEYQEIVKFTKMFNLWRLKTVESPSLPSSPVVLSTRLNKLNYSNDNTPALSPATTCSSASQTPIQTPTMQHNLINQATNNLHSKKYNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y524</accession>
    <name>I4Y524_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">VmaA</name>
        <name evidence="18" type="ORF">WALSEDRAFT_23147</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JH668263">
        <property type="protein sequence ID" value="EIM19066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960886.1">
        <property type="nucleotide sequence ID" value="XM_006960824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y524"/>
    <dbReference type="FunCoup" id="I4Y524">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y524"/>
    <dbReference type="GeneID" id="18470944"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_23147"/>
    <dbReference type="eggNOG" id="KOG1352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y524"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="228"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM19066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="609" mass="66962" checksum="27F44F0C0CFF0BAB" modified="2012-09-05" version="1">MTRNLKKISDEERESNLGSVYGVSGPVVVAQGLDGVAMYELIRVGHDELIGEVIRIEGKLAIAQVYEETSGLTVGDPVLRTGKPLSVELGPGLMSNIYDGIQRPLKGIREKSQSIYIPRGINTDALDRSIQWDFNPSVAIGDHLSGGDIFGSVYENSLLNDHKMMLNPRALGTVTHIAEKGAYNVDDVVLETEFEGKKSNHTMAQLWPVRAPRPVTEKLTANYPLLTGQRILDSLFPCVQGGTTSIPGAFGCGKTVISQALSKFSNSDIIVYVGCGERGNEMAEVLLEFPELTIEVNGREEPIMKRTALVANTSNMPVAAREASIYTGITISEYFRDQGKNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGGKLASFYERAGRVSTLGSPNREGSVSIVGAVSPPGGDFSDPVTSSTLGIVQVFWGLDKKLAQRKHFPSVNWNLSYSKYTNVLEPYYEENAPGFIDLRSKAKSILQKEEDLAEIVQLVGKSALGENDKVTLELARMLKDDFLQQNGMSEYDRFCPFYKTAGMLNNFITFNEQAQNAIADGDLTYNNIKEGVSDVMFKLSQMKFESPSQGKEDITAKFDQLNTEIQEKFRQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5A6</accession>
    <name>I4Y5A6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960810.1">
        <property type="nucleotide sequence ID" value="XM_006960748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5A6"/>
    <dbReference type="STRING" id="671144.I4Y5A6"/>
    <dbReference type="GeneID" id="18474641"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61616"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y5A6"/>
    <dbReference type="OMA" id="LANEEYW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="73"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="343" mass="39204" checksum="E9F1D9836BFC4348" modified="2012-09-05" version="1">MYFRSFLRGVNRKQFSYSNKRTFFFNAASTQLVGSSTTPHIVPSLIPYMVALLLAATNNNENCDNMDHIVADPPLELYDTKSAGIAVRASRDIKRGELLISELPLLIWEEGMSPEQLRHWTDQLTPSARQTLFNLSKRSDKLAIEAEEKDNTDESARIRSANGFDLELPGIPLSFHGKLPPQPTRASFLFPNISRINHSCLPSCGHALDWTRLRMEIFAMRDIHKGEDISIEYLPQMITLSTEERKAKLQTTFGFSCACQLCSSDNETIEQSDRRRKQLKLSSRNLFGAGLNRQQMVGELERMRVILQEEGYKVLPEFEQENISKAYAVFTQMRSNFIKQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5B7</accession>
    <name>I4Y5B7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_58889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960781.1">
        <property type="nucleotide sequence ID" value="XM_006960719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5B7"/>
    <dbReference type="FunCoup" id="I4Y5B7">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5B7"/>
    <dbReference type="GeneID" id="18473085"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58889"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5B7"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="258"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="40734" checksum="82832A14971A051A" modified="2012-09-05" version="1">MGLKALILVGGFGTRLRPLTLTLPKPLVPFCNKPMIVHQIEALVKAGVTDIVLAVNYRPEIMENVLKECEEKYNIKIHFSVESEPLGTAGPIKLAENILKKDDAPFFVLNSDVTCSYPFEQLRDFHNSHSSEGTIMVTKVDEPSSYGVVVIKENSSEIERFVEKPKIFVGNRINAGIYIFDPSMLNRIDLKPTSIETEVFPPMASDRQLHAFDLQSFWADVGQPKDYIHGTCLYLSHLNKFDSTKLVDVQTENWVNGGNVLVDPSAEIDKSALIGPNVVVGPNVKIGKGVRLQRCVIMDGSRIRDHSWIHSTIVGWNCTIGRWVRIENIAVLGDDVVVKDELHINGASVLPHKSISQSITEPKIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5K9</accession>
    <name>I4Y5K9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_70784</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960748.1">
        <property type="nucleotide sequence ID" value="XM_006960686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5K9"/>
    <dbReference type="FunCoup" id="I4Y5K9">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5K9"/>
    <dbReference type="GeneID" id="18475788"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70784"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="I4Y5K9"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="219"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="313" mass="33633" checksum="66F8392BC3487935" modified="2012-09-05" version="1">MSVAAQPPKQKDTKAFLTDFMMGGVSAAVSKTAAAPIERIKLLVQNQDEMIKQGRLSHPYKGIGDCFARTYKDEGLVSFWRGNTANVIRYFPTQALNFAFKDYFKSLFGAKKSDGYWTYMAGNLASGGAAGASSLLFVYSLDYARTRLANDAKSAAKGGGERQFNGLVDVYKKTVASDGIAGLYRGFGPSVVGIVVYRGLYFGMFDSLKPVLLQGSLANSFLASFLLGWGVTTGAGLASYPLDTIRRRMMMTSGGTGPHYKSMMHCAAEITRAEGVSSLFKGAGANILRGVAGAGVLSMYDKLQEILFGTVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5P8</accession>
    <name>I4Y5P8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960682.1">
        <property type="nucleotide sequence ID" value="XM_006960620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5P8"/>
    <dbReference type="FunCoup" id="I4Y5P8">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5P8"/>
    <dbReference type="GeneID" id="18474597"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61549"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5P8"/>
    <dbReference type="OMA" id="HVHINPI"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="35350" checksum="C7364EE66DE95067" modified="2012-09-05" version="1">MMADKDTIKELFRGLKDIKVINNDPLIKKAAISGLSSKNELAVIIFEKSAFHESNFNQFDHLIDNHVMIQQNDIYHVLTSSSTPTPNDQKVTVIYPATQKHLDKHSKSEVSLFRETPEVFNTIVKPYIDGLPLKETKWISSLVSGEAENETYYYKGNSFVIAADYKWDKQDLNTLYLQVVVKDLSLKCLRDLRSSHILLLKSMREEVGNVLKMNWDLDLSQVKLAVHYQPTYYVFHVHVVSVNYTSFPGLNVGQAHLLDDIIEMLSFSGDIFEKMTLTYHLSKLHALYKLLKPDTASLNTHDDSGKLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Q6</accession>
    <name>I4Y5Q6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arabinanase/levansucrase/invertase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_22750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960690.1">
        <property type="nucleotide sequence ID" value="XM_006960628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Q6"/>
    <dbReference type="FunCoup" id="I4Y5Q6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Q6"/>
    <dbReference type="GeneID" id="18470933"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22750"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_3_3_1"/>
    <dbReference type="InParanoid" id="I4Y5Q6"/>
    <dbReference type="OMA" id="ALWEMPD"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="366"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59338" checksum="A9AFA7D870380B8E" modified="2012-09-05" version="1">MKLPYSTLTSASLLAGRAATDNNQCFGSSTGQPLSEGTYAEPLRPQIHYTPSENFMNDPNGLIYANNVYHLYHQWNSKENVPGYQNWGHATSEDLLHWDLHPAAITPDNDDGPFIFSGSAVIDENNTSGLFDESTSPTNRLVAIYTEASSEKIQSQHVAYSTDGGYTYTKRPEPVIDINNPEFRDPKVFWYEQDSKWIMIVSLASQHQMIIYESKNLIDWNETSRFGNVGQLGYQYECPDLFPLKIEGSDEEKWVLITSVNPGAIRGGGSGTSYFIGDFDGKTFTPIDTAVREMDFGYDDYAGVTFNNVPDGRRLWIGWASNWLYTGNVPTEPWRSSLTLVHELSLTQVDLTDQHQALALRHKPVDLSSLITETVKETNSPMSSDSIDFPTKGAVDLSIDVSFSSETEASKSSKSASRITIESEDGVNSIEFGVQFSDHIVYVNRANSGWSAPTFGSLGATSITIPDDNKVNLRAVIDHSQIELFVQDGIHFASMVFYFQDGRVPARLRYENEEGVTIDHLKLDALKSIWEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y652</accession>
    <name>I4Y652_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OPA3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_70570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960476.1">
        <property type="nucleotide sequence ID" value="XM_006960414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y652"/>
    <dbReference type="FunCoup" id="I4Y652">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y652"/>
    <dbReference type="GeneID" id="18475760"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70570"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455085_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y652"/>
    <dbReference type="OMA" id="CMEANFG"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="600" mass="67557" checksum="BAFE3FA7DC753B0E" modified="2012-09-05" version="1">MSLSTKLGSLFIRTLAKPISSSLKNQASNHESFKRVCVNVAQGLHSFEGRMRSNLLGQKQHNTRPLSEARAIQQGANTMSEAFLFTVAAALILGETWRSSKKESTRREDVKDKLEMLDNSVKTLCLQNDELIHENDNLRAAFNKLINKETFKEAQKELELHLAAYYYRHNMGNTTSSSSTTRERGIDHVDGGTDWDKDVVRELIIQRKLAPFYKGLNDYNNEMSDLDILQEKYNGNFNSPNASPQTQIKSPRRTASNSSNQLKKPTVNFEAFIYRNAQECPICFLFYPPNQNRSRCCDQPLCTDCFVQIKRAEPTTTHLESEPAACPYCAQDNFGITYSPPQWRAGTGASPSQEINIDKALSNVEAPRQRRKSISADSPEVVTIDTIRPDWKLKLDHVRAQAARRANRRIIMRQVGDRLVPIGVTSSRHPLANSQLPTGLFLSSEGTVQSTQQASQQPAHRSRSNRAGRRAVDNLVNSLGTGADLEDAMIMEAMRLSLLDEQERNRRRDEEERDERQALERSSSQIEMSTDNQSVNTPEDAQPKPTTNTTQADEQSNVKNDNSEHSSLANEYREQRRLSDGSIDRTGLLAPTEGSTSHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y661</accession>
    <name>I4Y661_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_61453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960485.1">
        <property type="nucleotide sequence ID" value="XM_006960423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y661"/>
    <dbReference type="STRING" id="671144.I4Y661"/>
    <dbReference type="GeneID" id="18474537"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61453"/>
    <dbReference type="eggNOG" id="ENOG502QV03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y661"/>
    <dbReference type="OMA" id="WIYYACE"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52547" checksum="077752CF286394DC" modified="2012-09-05" version="1">MQSPKEYSKDYSYGCENSPTMTSLSASASTSRANSPPPMKPSLEQSLAFNLNGDIDHDEKTLTDEHNAPHRQPRSFFRRVHGWSWQAWPIAMGTGAVFVLMSNLYNAPDWVVYPELIFFFFVCALFIINVTLLLFQAILFPSQSIRLVKDPVKGVFVPLVVLSFATIVIGISQYGVGDFEVVPPQALVVLFWIYLAMANLVCVPMLVIWFNCEHSTTITSFSPAYMFLVFPLMLTGVVGFNCLNGVAKDSNDALVILIVSYVFQGLGTLVTFMYLAIYCLRIITTGFMEGHQANGAFVAAGPPGFTALALIKLGEHARDIFNAGQALNPLAGEVFYDVGILSGAMLLGCSWFFFVMAAIPWAFKVHFHSHEVLGMWALTFPLVGMISTFKVLGDIFHCKFLHMLHVVFTILILIAWVCLMTTTIVAFCRGKIFKSPTEEVLSDTVFPPLTTKKNHKSKSKQAAKRYDEAPYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Q2</accession>
    <name>I4Y6Q2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960307.1">
        <property type="nucleotide sequence ID" value="XM_006960245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Q2"/>
    <dbReference type="GeneID" id="18475743"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70453"/>
    <dbReference type="HOGENOM" id="CLU_1994385_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Q2"/>
    <dbReference type="OMA" id="KLYNPDC"/>
    <dbReference type="OrthoDB" id="3340335at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="14296" checksum="B620746D88C125C9" modified="2012-09-05" version="1">MTKLHYLLLCTTYHDPDVCGFNSWKRQWQLPCVSRINEKKKREYIDLIIHGVASDWVKSCLKDKEGKLYNPECLQVEGPPLVTNSAPDGNYIPLVKVDDRIELLSAQPIEGGSKKQRKLSKQGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y772</accession>
    <name>I4Y772_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960148.1">
        <property type="nucleotide sequence ID" value="XM_006960086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y772"/>
    <dbReference type="STRING" id="671144.I4Y772"/>
    <dbReference type="GeneID" id="18474445"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61293"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="I4Y772"/>
    <dbReference type="OMA" id="WAEVPDP"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="335" mass="36244" checksum="240B3D7EAF70AD8F" modified="2012-09-05" version="1">MTEMRAVVVDTPNEIAKSNNDLKLSTIPKPTIKSGEVLVKIVAFGVNRMDLLQARGLYPLPPQAPKTLGVEFSGVIVDVSENSSWKIDQEVFGLAYGGAYAEYIAADQNMILEKPDYLTHIQAAGICENYLTAHQAIKTIGKIKPGSDVLIHAGASGVGMAAIQLARHYGAKNVFTTAGSDDKLNTTKSLPLGATHGVNYRTQKFDEEVLKATQNKGVDIIVDMVGQSYFNANINALAKDGHMIMLGVLSGMVAKEVNIGPIIFKRLHIEGSTLRSRPAEYQGGLLKDFKNCALAEVGKTFDLKIHKVFKWTDIAAAHDCMSNNENTGKIVVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7A3</accession>
    <name>I4Y7A3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960179.1">
        <property type="nucleotide sequence ID" value="XM_006960117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7A3"/>
    <dbReference type="FunCoup" id="I4Y7A3">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7A3"/>
    <dbReference type="GeneID" id="18474453"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61309"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003224_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y7A3"/>
    <dbReference type="OMA" id="SNAFMTN"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="850"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="943" mass="106734" checksum="F9D9E4876F557AD3" modified="2012-09-05" version="1">MMDDGEMLTVIASLPANQTTFEYLVGAWRRARGQAVQLNKIDYSPADKQRGMSVINKLKELLLSYIGLTLQDPTMFVQTSDKPSGAIEFLQILIPDEASADPYGDKKSTRDISPELQNVPVSDLLADIVKRFDGDGLEDVITPIIELTAGQAKGLDLTGMQWRSIITALETLLQFKPIAGIFTTLPSFIPTPATAKSIENDSLLGPLIGLSTFSSSAPNIAKLYFSDASLDREEQSPITQNTLRATLDSLQASLFGIFNVLVRTSPQSRERVLDFFAIAANLNGHRGAMRVDPKRVSGDGFMFNCQVILSRFADPFMDATFSKIDKIDPKYFCHSKRLDISEETKIKADKTESDTFYNENSNKDHPVNFISEVFYLSLAFHYLGYHSAQRQSGSLKKHIDMIEPQLNAQRNQLLNDPRFAPGTPGRMFAEKQLEKQEILLKERKAAVASSWIQLDDPASMTRILGFYTFVTTWIVRFVDPSHQHPQKLVTLPLPDEMPVEFKMMPEYILESTVDFFIQLTRYQPHQLESSGKEELMNFLVTFICSPKYIGNPYSRNKIVEIMWNGTHPFGYSRSGVLSDSINYHKLSLEHLMPSLMSFYIDVERTGVSSQFYDRLNVRYNIARLLKVVWNNPTHRDKLKEDTMNSDKFVRFTNLVMNDSTYLLDEALGKLASIRQYEEELNSPGFSNRPDNEREEVQQSFEESGRAAGSYTALGGESVRLLKAFTAEAKAAFMAPEIVDRLAAMLCYNLDALAGPRCQELKVTNPEKYGWRPRQLLTDIIDIFMNLLDCREFIEGVAKDGRSYSKTLFERAAGILRRKAIKTDQEVDLLARFVNQVEQVRAEMMEEDEADIPEEYQDMIMATLMRDPVILPGSKAVLDRSTIKSHLLSDNTDPFNRSPLTIDQVVPHTELKAEIDEWVAKRRQAKLDEMTNATNAVDVLPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D0</accession>
    <name>I4Y7D0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960014.1">
        <property type="nucleotide sequence ID" value="XM_006959952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D0"/>
    <dbReference type="FunCoup" id="I4Y7D0">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7D0"/>
    <dbReference type="GeneID" id="18474408"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61233"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7D0"/>
    <dbReference type="OMA" id="NCEKGVG"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="854"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134249" checksum="197D2C1310FE2DFE" modified="2012-09-05" version="1">MSSEDHLNGDHQQPQQSEQPEDAVDIQDIYESKENIQPLAKGRSASTLSSIFRSDRQSRKRELEEQHQKFEEQIQQATEEDDDPFRVYSDYIKWAIEAYPSGESHESNIVPLLERTTRTFKDDERYGRDVRYLRCWILYSKYVHESRDIFRFLLANDIGTIWGLLYEEAATAEEVRGHHQKAKEIYELGINRKAQPTERLKKRYEDFKVRLANAPPSTGQSSLPKKGILGSSSVAGPTASTSASGSSSAAPRMAIFSEDDSENASGGAWERFGSRDDRRKENVVEKTSMKGETIQQGKPITPKAEKVPIFSDFNDDDEATNDGPKEADLGSSEVSEAEQLRLNPFKNFEQPPKLDMDVVSEKKKSSSNGTSSSSSSKKKEKSKATDSVNKGEPRVAVDLHRVYCDDTEYCFLELKAKQMGLFGKRWPEPSSDDWDWMPKDEPSIDEKPRKRAPSPTVNTKAALDDVMELFNQPLACDRPNTSLSDSDSSVDAPQPLVMPTPNKPAPMMMFTDEHTARVPPAVAEDEEDAKSPPGPPPAVFKDENAAAVSTPAVKSSSGAMRMPFGLKAPQEAEEMKETEEPPAETVQEEGIQEEYYDDLNKQPRFPPINLMTPITERTCEFTTRVDTVEKSRAVFPAAQFQATIKEENEENSMTSNNNLQNSMISNSNMNNSILGNQQPLSSTMEPPQMPTFELGDEFTQHDITSHTGKFELPEGFTIHPGGLQQMGEDVEVVDTMKFNLSSNNIPQPVAQLQMQAQLSAPPSPAAPVSPGSGKIDAPNPCVANTRTIVDSIIKRSNLNVSNLSTFHTAQNSLQELSKVEKGVKKRTASSRNRTMEEESYALKLPKYDGLDDVYDVRAKIGQGGFGSVFVASERSNQKSVELDLENFDNSFTSQFASNEDVPVALKIEKPARIWEFYILNALHQRLEERQRRSIVRPRGLYAYNDESVLCMDYADQGTLLDVVNHAPEWFSSSSTGLDEVLVVFFAIELIRTVNSIHKSGIIHGDLKIDNCLIRLEDAGELWSNVYQRSGEGGWAMKGLKLIDFGRSIDVDAFKNPVGRKFLNDWPADEKDCWQIKKKVPWNFEPDYFGVAAIIHCMLFGKYIETIESGGRIKLRNNLKRYWQHEIWSNVFDFLLNPVMHKETLPALSKLENLQTKLEDWLEANCHTKGRNLRFTVKMMERRCRELAASRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7K1</accession>
    <name>I4Y7K1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_65944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960081.1">
        <property type="nucleotide sequence ID" value="XM_006960019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7K1"/>
    <dbReference type="FunCoup" id="I4Y7K1">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7K1"/>
    <dbReference type="GeneID" id="18475071"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65944"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010374_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7K1"/>
    <dbReference type="OMA" id="SFWICPR"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="434"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM19943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="58124" checksum="41268516AE458373" modified="2012-09-05" version="1">MRVLSWNINGIRRILGNYKSCEEFVRGLEADIVCFQETKAFKSALGASQVSFDTFQSYWSFCHSNRSYSGVCVYSKETPLAVEEGLSGGYTTFSVSIPQLSDEDKLKPLANIHSYNQETLLGQNYHPDFTNVKQLDTEGRALCLDYGMFVLINVYCPAEGDESRVKFKKSFHELLFERIRILKEGGRQIILLGDINIAHRAIDHCDGLELTRTDIGKMEFETKYTRQWMDKLVSDDNSPLVDIMRLFHPTREGMFTCWNQLINARPSNYGTRIDYVLITPGLIPWVKEADIAPSVYNSDHCPVFIDLHDSIPDPHDDTKVLHLKDYLSKPKGAALPPLCASNWDEFNGKQTSLSSFFQPGIKKISPSRSLSRSTTPKNHRDQPQIESFFQPRGRTNSGDHNNPANPTKKQKVDNDKTIKSAWKALMAPKRVPKCKVHNEDCREYTVNKPGPNKGKKFWLCSRNVGPGYDAGGSKRNRADVDSRYRCNFFVWSSHLERDMSGIEDYKSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Q5</accession>
    <name>I4Y7Q5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_40503</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959928.1">
        <property type="nucleotide sequence ID" value="XM_006959866.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y7Q5">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Q5"/>
    <dbReference type="GeneID" id="18472176"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40503"/>
    <dbReference type="eggNOG" id="KOG1798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7Q5"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1490"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2211" mass="251967" checksum="B60A09F5D40D71A1" modified="2012-09-05" version="1">MSRVRFRKPAKNTRKGPSTPQVLDERQILAQKFEKLKECDNLDATLGFSRYEQGPAKEGWLVNMHPTLIEDPDYIGGKAGVDFYFIQDDGGMFKSTLTYEPYFYLCCKPGTEAAVEEWLLRRYEGTIYRIERAHKDDLKSPNHLLSLPKAYLQLKFRNVQDLLTIRREVLPLAQQNAERRSAVDAYADVVATAEQDVTIEEEQNARSKEDPSQLIIDAREYDVPYYLRVATDLGIRVGLWYTVTGNEGKVKMDKIPDRVKRAEPVVMAYDIETCKAPLKFPDSAVDPIMMISYMIDGQGYLITNREIVSEDIEDFDYTPKEEYEGPFTIFNEPDEAGVLKRFFEHIREAKPTVMATYNGDFFDFPYVDARATANGLSLYAETGFQRDNEDEYKSATCSHMDCFRWVKRDSYLPQGSHGLKAVTVAKLGYNPIELDPELMTPYAIEQPQVLAQYSVSDAVATYYLYMKYIHPFVFSLCNIIPLNPDDVLRKGSGTLCETLLMVEAYSAGVIMPNRHVDPHGSMYEGHLLSSETYVGGHVEALEAGVFRNDIPTDFKIVPKAIQQLIDDLDNALKFSIVVEEKKKLEDIENYDEVKNEIKGVLENLRDNPNRQDPPLIYHLDVAAMYPNIMLSNRLQPDAVVDEGMCAACDYNTPGKQCDRRLTWAWRGEFFPAKRDEYNMIRHALESESFPGKYPGASKRRFIELSTTEQSALMHKRLGDYSRKVYRKTHDTKIINREAIICQRENPFYIDTVRAFRDRRYEYKGFHKQWKGKLDSANESGSLSASVEAKKMIILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGATIIQMARQLVEQIGRPLELDTDGIWCMLPGCFPENFKFKLKNGKTMGFSYPCVMLNHLVHDKFTNDQYHTLTNKEKGEYEVHSENSIFFELDGPYRAMILPASKEEDKLLKKRYAVFEEDGSLAELKGFEVKRRGELQLIKFFQSEIFSKFLLGKTTKECYDAVAKVADQWLDILFGKGVTLSDEELVELISENRSMSKTLAEYEGQKSTSISTARRLAEFLGEQMVKDKGLSCRYIISAKPIGAPVTERAVPVTIFTAEQSIKSHYLRKWLKDNSLTDFDIRSILDWDYYIERFGSVVQKIITIPAALQKIPNPVPRIQHPDWLYKRIANSDDKFRQHKLTDMFEKQREINQDMEDLGVGSSVPGKPKQAVVRKKNRQQTEEEELAKILEISVPDPDEDYSAFIKVMRKRWKAQRAFKRKHGSKASRNEAGVSRQTALGMFQDHSLGFSGSSWDIVQVYPSVRPGEFRLWLSLGGNFQQVRLRIPREFYLNLKSVPDEGVFAEEYLVEKVIRTLPRDQPCLNLFKLTVPERLYIDNESHFKNLTSNINVDSVYEMQVPLIDRALMKLGSKCALSKSSGGGLSKGLDRGFDLMDLSSASQPTAGRNYLQNFNQSRYIYIFHANVDKRHIFGVFTSEQGCKIFIVDSTNRTRPQLPNLEKVYGQTYDNYINRKSDDFEEAFEYSSEMEFDITFHGSEQSAVKNMFRHLNGLGGQRHGPTIAILNSPQSQSYFSQFGDGLNNYPVIAVPTSRKDLSVDESLMWLPKISKRMIGMYFRMSTWINERVGLAKHYDVPVGNIERDAPIQLADISFARRLIKSDILLWWSHSSKPDLGGREQDVPPQQFADEGGGPIEFSNPGTFSNVVLEVELRDIAVNSILQSSLVNEMEGAGSAATVFDSTSHTIDEYTKGQAKALVTLGEAVVSSQVFSILKSMVKSWYLDKARSADGQNAFGHLLVDHLLRWISSPVSRLFDPGIHRFLRGLMKKVFLQLLAEIKRLGSGIVYADFGRIFILTSKPTAGSAAAYAQYVLSATTSAELFKHISLNTVNFWDYLVFMDLSNFGGVINHNPSSAEAPEEFHVDMKWNIPQYLPTALQTYFDVVIAEYIYAMYSEKRKLGLQYRTPLRAIAKEGGELAVDEYKKQEIEFERSLITRIMTRRLLKIVTDMSKKQTEAATELASGVEDNEEANMFIFPLLPGSQTNMKNPTLEFVKSTCAVLALSKDVAIEVTILKRNLLDVLKVREFSEDAQFKPPCESFKVTGVVCKACTFVQDLDLVRDVELLDDDWPCASCGRSQDKMEVELTLLGMVDKLVASFAVQDLKCAKCGSIKSSDLAPHCHCSGAWKLTTSREMFKRRMEVINSIARYHELKMLEEHTESIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7S4</accession>
    <name>I4Y7S4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61184</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959946.1">
        <property type="nucleotide sequence ID" value="XM_006959884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7S4"/>
    <dbReference type="STRING" id="671144.I4Y7S4"/>
    <dbReference type="GeneID" id="18474378"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61184"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354199_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7S4"/>
    <dbReference type="OMA" id="IYYMDER"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="793" mass="89010" checksum="19B517DF867555DE" modified="2012-09-05" version="1">MSRRLKITARSRLQIVKNPQFIAEAYTFEDDSKATTGVDSAEAEETHLQNAISASKQRNARQNQQVISSPKKNKSTPQSKPQEDDALGIIPTPDATGRVTNYEKLYKPLPAPEAWSYIKYSDTIEEAQLGGLIYTIDERDFRFIQEHNKAVKGEGTSTDGSKNDSDSKNTDMLIEEDTFELIMSVFEKVTDDIAPTLHTDISRIPEFSEFESHFRKSDFLDYFPNIAPLKLTLTPDNLVKLGQIIYQHWRARRVRRQGKPIHPQLNYDESNDGDPYVCFRRREVKPVRKTRRADLQSVEKMEKLQKELLAAQQLVVSVIEREKKKIEAVEMDRGISNLRHKLRNVKRKQGVIGPDDGKADDELLTGTKPKRIKVDSKLTNKRTTGSPAVSVSADKGSVPIAALIEKHILAKREADQMWEDFSDPSQSSSNFPGARFFRSLSSHAEHDDEMGRRSFRMRIGRGGRRILDRRHPFIDNDEDALVHLNDDEKRMRQLQKFDSNVVLKSNIKGLGPTFGEDGNNLLVDDYDERFMRYRASLLNEEDIKNLTASTPSVDAAMQAALAPPVPLPHYTIVRPNASSKAQQLQRNNSNASNVQNSGKPQVAQHLIRKASQQNAQGAPLQRNNSAMNGTTAAPAPTASKQPTPKPPTPQMNGNTALPNSNATYNTIQQLLAVQQQQQQHQQPQNPAQLNALLQSTKTQQQLNQMRQLIANQNNNNNASNNQLNQQQMLAALIAKQQQQSRQPQASQQQTNAGGMTAQQIASNPQLAAFWRQQLLAHQQAQLQQSNQSSNGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V2</accession>
    <name>I4Y7V2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">WALSEDRAFT_40569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959973.1">
        <property type="nucleotide sequence ID" value="XM_006959911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V2"/>
    <dbReference type="FunCoup" id="I4Y7V2">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V2"/>
    <dbReference type="GeneID" id="18472179"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40569"/>
    <dbReference type="eggNOG" id="ENOG502QUN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026505_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7V2"/>
    <dbReference type="OMA" id="VPGYRQI"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="447" mass="48865" checksum="E68F939A844DDB2B" modified="2012-09-05" version="1">MINYAEYILRSYFRATEWNPDAQYSNLNRASAAILDFYPPQALSVSLSSCPTQAFASSCSLSILPSLSGSLAYLASSIDLPKDKPSLHSLVHTFNISALPKKPEYDPSRKDQLLYGQLHLPSSRLHSLYTRRLSPQSQLLISSISHPRPPTREEPSEMYITYQKDQGNYASELSYSVADGMASASSLFHFGLIDKNYRENSESSISDNKVVSSKRIDEDPDGDGSTGLKGHFSLGGEIYASAQEKSAGVSTGLRFQTLPETQSPPTVLVALLSPITGYLSGTYSATIAKGLSVASRFEFNLYSYESVTTLGAEWAIPRSRPDEDEYFDENLQEMVKPHPEEGTISLLNQGAASLAIQDVRHTNQNTTTKSSTPIPLSASAAINENDPIQGYLKARMTTEKSITLQYAGRLKSMLVSLGLVADLSNPHKPVQSIGLELQYLSPGNEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7W1</accession>
    <name>I4Y7W1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959982.1">
        <property type="nucleotide sequence ID" value="XM_006959920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7W1"/>
    <dbReference type="GeneID" id="18474397"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61213"/>
    <dbReference type="HOGENOM" id="CLU_2428744_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7W1"/>
    <dbReference type="OrthoDB" id="3361941at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697473" description="RxLR effector protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9964" checksum="66146A7973ABC5A9" modified="2012-09-05" version="1">MKLAAVFMLALGSAAAASINTPSIALRNKNHFSLDSDVAAHALYGIKPEYRNEVLKYHRLGNDDRARAALIAGLNDRKAYQLIDKLQKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y845</accession>
    <name>I4Y845_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959858.1">
        <property type="nucleotide sequence ID" value="XM_006959796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y845"/>
    <dbReference type="STRING" id="671144.I4Y845"/>
    <dbReference type="GeneID" id="18474356"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61143"/>
    <dbReference type="HOGENOM" id="CLU_422852_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y845"/>
    <dbReference type="OMA" id="QDNSENH"/>
    <dbReference type="OrthoDB" id="10579980at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="648" mass="72298" checksum="C25B24D9FDEC1D91" modified="2012-09-05" version="1">MGFTGDNGGFSFGGNSSPTATEHKKADRPTHGRRHSHRRHSSVSTRRDSMQLMSGNQFNESFLDNLDTAGPSNSQDVALSKEDETALENGFVSASNSLSSDGFLVMPTSQQIDQLSDNSDSSPNSPSASTTFSGIPTPQSQQIRRPSPMSISQMPQPLGALMEEEEDDEDGSTKTSRQSKPSFKTYKTKRNSVDFDSIMRTNGGPSAGNRPIRPLSMSNSTGKSPFNFTSKVSQPPTFQRSGSSSSESLSLGHSQSSIASSISSPFTSMSFGKSADFDYGGMPPIPSGSTSSSSTTPPRRQRGSIQYRRSDDIDDSPASQVSNKNGPKPLNLVNKARSGSNSSNTSTETSDLFNSSPSNKAFLEQQLTTTLEDLSIWRDKNAALERDLSIERKERLASEERVKRLGEKLNQLPNLQEYQMQIQMINEMREQLFYLSNELEEFKKVNSRSQEEISELRSQLREKDQREGERKEREREKEKEIKTEKEKEKLDTEATNQDEEKPVRPHSLLIDWRFPMSANNNLSPKIDEDEEELEEPSPTVDYNDAFAHNSSMSFGKGSVDDENFGLPPISTPPAQVRNDNFGFFRSRSNSLLNKVDKVRNSFSPSPKYEKTVYVNKEKQLDKLSYDNNNEMIDFAPCYLQAGYNLTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D5</accession>
    <name>I4Y8D5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959715.1">
        <property type="nucleotide sequence ID" value="XM_006959653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D5"/>
    <dbReference type="FunCoup" id="I4Y8D5">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8D5"/>
    <dbReference type="GeneID" id="18474316"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61063"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8D5"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31317" checksum="89E73F7CAECB010C" modified="2012-09-05" version="1">MSLQQPIKATTKRKTVEDDEDNEIVNVDFDFFNIDEIDYHAVKHLLVQLFHSDSQDLELHTLTDLILSQSGVGTTIKVDGKESDPYAFLTAVNLNSNNSIGCVSNLSNYLLNRAKSASNQSLYNTLNQLLSGESSSQVGLLLGERLVNMPVVLMPHMLRFLLEELESASKSGQAYNFTHYLIPARTYIESDNDVEMDDQGPTKKQRGGNNSKLQTFHPEDDITQDFTELVADYQYKNVVTREQDAFGADIRGRLILIEAEKLKNLVLPKMIENTSAAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X1</accession>
    <name>I4Y8X1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isy1-like splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_39789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959439.1">
        <property type="nucleotide sequence ID" value="XM_006959377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X1"/>
    <dbReference type="FunCoup" id="I4Y8X1">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8X1"/>
    <dbReference type="GeneID" id="18472131"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39789"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8X1"/>
    <dbReference type="OMA" id="YHWERRI"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30736" checksum="FEBD914307E38C0D" modified="2012-09-05" version="1">MARNSEKSQSMLFRFREAKLSEMGMATRFSRRPKMVSLVTSIRDCERFRGEILREISRKVDKIQDAGLTDYEVRDLNDEINGLLREKANFERQIVSLGGANYRRAGVMLDESGKEIPGTRGYKYFGRAKDLPGVKELFERTDQEEEAEDDLYKPFTDQGPEYYGDTTEGNDELLAYEYELEQKSHQKAIDRLKVVFNTADLHDSQKTEIPRPLGDLVNGVKTNKLTNIHSDFIQDAYLETPQLPTKEETDKALLDIRKQALMSEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y957</accession>
    <name>I4Y957_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959525.1">
        <property type="nucleotide sequence ID" value="XM_006959463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y957"/>
    <dbReference type="FunCoup" id="I4Y957">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y957"/>
    <dbReference type="GeneID" id="18471657"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33342"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="InParanoid" id="I4Y957"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="547" mass="58965" checksum="5F1C7B9DD988C428" modified="2012-09-05" version="1">MDAIQPGAAVYTQDEHGNPFIIVREQDKKTRTRGVDAIKSHILAARTVANIIKTSLGPRGLDKIMISPDGDITVTNDGATILSLMEVDNQVAKLMVSLSKSQDDEVGDGTTGVVVLAGAMLDQAIGLLDRGIHPIRIADGFDRACKIAVSELDKISDSVEFTQDGKGVGTAALYKAASTSLGSKIVSAHSKFAQIAVDSVLSVADLERRDVDFELIKVDGKVGGSLEETSLVQGVVVDKDMSHPQMPRSVKDAKIAILTCPFEPPRPKTKHKLDIGSVEEYKKLEAYEKDKFADMIKKVKDSGANLVICQWGFDDEANHLLMQNDLPAVRWVGGPEIELIAIATNGRIVPRFEDLSADKLGHAGIVREVGFGTTRDRMLVIEECANSRAVTVFVRGSNKMIIDEAKRALHDAICVVRNLIVDNRVVYGGGAAEIASSIAVTKAADETPSIEQYAMRAFSQALDAIPLALAENSGLSPIETLSDVKSQQVNDKNPNLGIDCMGRGSYDMKAQNVHDPLVSKRQQYLLATQLVRAILKIDDVITAGGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y974</accession>
    <name>I4Y974_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_60990</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959542.1">
        <property type="nucleotide sequence ID" value="XM_006959480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y974"/>
    <dbReference type="GeneID" id="18474274"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60990"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001871_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y974"/>
    <dbReference type="OMA" id="SWKVHKG"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="735"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123001" checksum="50B38344330C1C1F" modified="2012-09-05" version="1">MNDNDKLTFSINDNTLLPTRFAQSITAIALSTKFSLRTAAFLIELFLDGFRNTTTSSIDIARRATITAINSALRRYDPSSDYIDLDKLSLSTGLAALGINCSSTANPDEVHRKLLEGYTGLGIYVVHHSFTLAELFAHAGFYLTQKTIKTSFTLAQDSVSVFDGVFGSNETSRALSSIISFMSKENEAPKNMSYMSWVVALTKAFTAFACLQNATQKRILESQNMKVVWDCVVVNRTMDSNPTPTMEKKPKSVGDTLAGLAAVLESYRYKNVSSSGSSLSTSSRTQSPASQPDHGRSMEHSIMKKKSGNMLSSREAKTSREYHKRNLSNDERKDLITTLTELLGETYVNDNRLDEVCDCDNSDTIKKTIWEMITENEEQIVTTETRNMNFNGLNNEYNDLNGELNGKTHNQTNTVQFPVEPRSAPQTPYQVAQNQSISYFPSYSSISCLPSLTTEKQRFSIASESYADALSHPGESKEKLQNVLRTVTTRLTQRHVARKIEINGLEPTNYKLSRKMSTPELRMTHINNHKSGTPLQNTKSHQRNKSIGTHTHPNQIMNDKEYLDNTINNVQNAADNLALPQFSNIDEQPIAPPSSPVCRANHVTEETLPHMRRIMHQPRAEPVKDAVEETSQGVYWPRQHIVKNIHRFMRYSSAAYGKSFMRILGIGKCDWDKLPLGEGDHHANHHAFAYHNNISIDAILLSSYTDPPVGFNSDDNKICPLVHYVAVDHDAKSIVLTCRGTLGFQDILVDLTCNYQEFELDGGGDPFGYYAIHQGMLISAHRLASESNTVLSTIRKALSDFPEYGLVLCGHSLGGGAAAALALIWGTRTDVFNKQAKEKGIPFDDVHSTSFVTGFKSGLPPGRPLSCYTYGTPCVSTPDLTAYAKGLIISVVNNKDIVPTLSLGLLHDMRKLALMLHEEEGNIADEIIGRVLGFGGTHRSDDTYEKPNLDQVNEKLRDHDQIVSFISKEDAKIGHTSNAILKPGYIDPALIKADTVNHDNELNDWLWSLKTTIGADMDSIKLYPPGEVFVVERSTCFVSLAEDDGDGNEGYSSAYKQEAHRVILRYCQNVEKRFNEPFFSKSMFTDHSPVEYERATQLLFDGIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y977</accession>
    <name>I4Y977_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_20591</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959545.1">
        <property type="nucleotide sequence ID" value="XM_006959483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y977"/>
    <dbReference type="FunCoup" id="I4Y977">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y977"/>
    <dbReference type="GeneID" id="18470844"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20591"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="I4Y977"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="20626" checksum="EB18AD3BF59C773E" modified="2012-09-05" version="1">MGLSVSKLLSTLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERVTEAREELQRMLNEDELRDAHLLVFANKQDLPNAMNAAEITDKLGLHSLRQRTWYIQATCATSGDGLYEGLEWLSTNLKNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y984</accession>
    <name>I4Y984_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_29465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959323.1">
        <property type="nucleotide sequence ID" value="XM_006959261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y984"/>
    <dbReference type="STRING" id="671144.I4Y984"/>
    <dbReference type="GeneID" id="18471101"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29465"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y984"/>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="511" mass="56138" checksum="8B64083FBE86A566" modified="2012-09-05" version="1">MSDKDQWGQSYPPNNQQYHLQQPQYAPQQPQQPPPPPPIDEKGSRFKPKLRLRDPIFFVLFLCTFFAFIGLSGYALHEWTQASGISSGLGNTNATNNATFTKETGYLLVVDAGIGLVFAVIYLLLLRIFTKIILEITLVLSILTTWALAIYQFTQHYWSGAIVLLIIGILQVVFYFGMRRRIPLASLLLKIVIDIAKHYPSVYVVSFIGLIVQTAWSVFYAFGVAAIYVVWTPGSEICGSGTGGSCSSGKVAGLVFFLTFAYLWVSQVFGNIVLVTLAGGPYGGWYYFGPYQQDGSGMPKHPTPSAFVRASTTSLGSIAFGSLIVTFLEIIKMIFRALQNNADAAGEIGKILACCAVCVISVIEWLVKIFNKYAYISIALYGKSYIKSAKSTWHLFKDRGIDALVNDSLVSIGLTYGSYFVGVLCGLFTYIYLKTASVEWNSDGQFTAPLLLYAFLIGFTCSMTLLSGLDAGVSTLFVGMAEDPGVLAQRAPPLFEEIRRVYPHVVQGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y992</accession>
    <name>I4Y992_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959330.1">
        <property type="nucleotide sequence ID" value="XM_006959268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y992"/>
    <dbReference type="FunCoup" id="I4Y992">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y992"/>
    <dbReference type="GeneID" id="18474205"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60850"/>
    <dbReference type="eggNOG" id="KOG4200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_814331_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y992"/>
    <dbReference type="OMA" id="HSKQVQI"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38410" checksum="3D32FF21E7533E4C" modified="2012-09-05" version="1">MTKLNEILTRILNSNVLRWLLRVAIFFIITYLSIISAVVSYSSFRWYIVPSRGWSLPINLQYGLGKVPFDTVSIPMDSVSPDQTYDLSLELKVPNDINNLNLGNFMITLELENTFSNELVASKPALLTWQHPNVLTSLIFKKAQKIKVPLSSTILKPSTRSLRQMSFTAATVTVGRQDWIADNVTLPQKELHVYDASLLFNIKLVGLSWLLVTFPITSFVIFTAGSFILIWSVAMLVWCGTNQSGQLTEDDEDHKALPEGEEETQDKETEVSSREETPVESVTLDGESISSSQWRSYDSDSEPAETPSERSLTPSNANEDNTLRQRVVRDNQQLDEDDIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9E0</accession>
    <name>I4Y9E0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_58076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959372.1">
        <property type="nucleotide sequence ID" value="XM_006959310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9E0"/>
    <dbReference type="FunCoup" id="I4Y9E0">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9E0"/>
    <dbReference type="GeneID" id="18472983"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58076"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045719_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9E0"/>
    <dbReference type="OMA" id="RDNTDVF"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40007" checksum="520DE5B49177B175" modified="2012-09-05" version="1">MSLFGNTTSGGGGFNFGATAQPQQQQASGGFGFGGGSNTQASNTAAKPSLFGGAAAPTATQQPATTGFGGFGQQTQQPQQNQQQTQPQTGLFGSQQQSSTTGGTFGGFGQQQQQQQQPQPQQTNPLGASTNTPFGASTGFGTTSTLNQNTQNAQNTSQTAKLTRTTKFNDLPDAHRKIIEDIDAHIQGRSHIALALKAEPLGKDVDRSSVLLDQVSNDLMSLQGTLASTAASLDSLKNDTEQDTVRALTMTRIIDGYRRPQESGAWLKTYRDFPHEFFAQTAVDLKDRANKYTGTLEQIEKHLSYLLTANAAGHTPQSIAQILQTQHATFMSLASNVAELAAATTNLKDGYRDIWRSKTKSYADPFALSNVESNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H2</accession>
    <name>I4Y9H2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_65282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959402.1">
        <property type="nucleotide sequence ID" value="XM_006959340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H2"/>
    <dbReference type="STRING" id="671144.I4Y9H2"/>
    <dbReference type="GeneID" id="18475006"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65282"/>
    <dbReference type="eggNOG" id="KOG4500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434267_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9H2"/>
    <dbReference type="OMA" id="NGTEHQM"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="551"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="630" mass="69779" checksum="4EB5DC5BB58599F6" modified="2012-09-05" version="1">MDDFIYVARDSTSDSAKLVEISRNLADSLRTPEKRDQLSNSGNVFTVLNTQLQQSIALNSDPLKLERLTQLCRVTANICLDNDTNRQKLLDAGVHSSVLALLNSLTPQEISNKSHSVVLRAAFGTLLNLSQDYAPSQEVLNSVDALSTVFKFLNRRTITAGESDTAVLHSYIYEWGWRIVNNLLSSEHAKVEPGVTEAEALFSWVEAFQNDTITKTYTGLDQDDELQGVYEEDLSSLESATMLLETFAFDSETVRLCLADQSKLDVLLAFAETNELPRAYLESADNATIDEWSKIYEECKSAVGKCIVGISSEDKLMNTLFDHGKGSFVQRMLIWLNNDQQRLNISGTLAIGNLARSEENTTTIVRDFNIIPRLVALLQGDDVKVSHASMSLLKNLSLPVLNKEVIGKSGAIEAAQKFLSTSFAHVQPLQFATVGFYKHLCTQQLENTLAIVNHDPPILEAIITLINKSDDAGIKSEGTRVFVHGIKSCWMSTDISAQEARSRFIQQPIAKVLVELLCNTRKYQILTNEAIMALTLLASDPAGANYILEENDNLASTLKQLLQDQNEVNKKLKLNICVFYSNLILKQTEQKLNAEELKNSLESDIKLLTEDSDSELSKTAATVIAATNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U0</accession>
    <name>I4Y9U0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_47219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959263.1">
        <property type="nucleotide sequence ID" value="XM_006959201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U0"/>
    <dbReference type="GeneID" id="18472411"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47219"/>
    <dbReference type="eggNOG" id="ENOG502QUR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046567_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9U0"/>
    <dbReference type="OMA" id="KYLHARM"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF1">
        <property type="entry name" value="DUF659 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="426" mass="46611" checksum="0373239E9088D913" modified="2012-09-05" version="1">MDSTGSMGSYLDNATKNVIEICQTIIQSEKLQGEHALRLGLISYRDSKPQDYTYETKNFGFTHDYDQMRENLKSLYASGGGDGPEAVTIAMKEAVENMPWRANASKMAVLVADAPPHGIGEYGDGFPEGSPCGNDPLQLARVMASHSITLFVVACEPALSGYQYSTDFFKALADLTGGMMIPLVSASLLAQVIIGSALEQMDIERLIKEVGSAVAERVHGQNENVDDVARALHETLMLRNESTKRIYVENIYRESEEADYNYNVWRNIANIQDAKGVVKRVPGSRFTDKYLSMRYASPPSYSYTTGAPALPARPGASSTSESSRKPLSSFAAFSAGPQLHNTSIMSTPVGASTTSAAFSGPRTSTRNEDMMDDDSDDEKLIDQQLGEEDDVMQPDEGVQFRQGAITYDQARRITTASAWRSAMAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9U3</accession>
    <name>I4Y9U3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959266.1">
        <property type="nucleotide sequence ID" value="XM_006959204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9U3"/>
    <dbReference type="GeneID" id="18475619"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69652"/>
    <dbReference type="HOGENOM" id="CLU_1929214_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9U3"/>
    <dbReference type="OMA" id="YGTHAPQ"/>
    <dbReference type="OrthoDB" id="10469416at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14434" checksum="7B2A6CFC8A36F2AC" modified="2012-09-05" version="1">MSKFVRGSLTGVIVAAAASYSFSEAIGARTDDMTKELREIRQYYRSQSAPEEPLQAQKKAYIKSSEPSLAEEFQSKWNDQVLNFIRARQGAYDADSIINWAVDKLTGAVDAVETVENVGTTSAPPVEKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Z0</accession>
    <name>I4Y9Z0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959307.1">
        <property type="nucleotide sequence ID" value="XM_006959245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Z0"/>
    <dbReference type="GeneID" id="18474998"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65200"/>
    <dbReference type="HOGENOM" id="CLU_2374376_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Z0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="95" mass="10805" checksum="270DD6DC8A232B96" modified="2012-09-05" version="1">MHDITVHSSIALVPHIQQVTKDWQKKSGSELIRVGLNHQAHKKVLKYRNHVPVTFVPIVLAMAQDYPQLGPPTEAYFVCTRKEKSDKLPLDLGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA30</accession>
    <name>I4YA30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959084.1">
        <property type="nucleotide sequence ID" value="XM_006959022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA30"/>
    <dbReference type="FunCoup" id="I4YA30">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA30"/>
    <dbReference type="GeneID" id="18474121"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60719"/>
    <dbReference type="eggNOG" id="KOG1560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA30"/>
    <dbReference type="OMA" id="RLETMCA"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="eIF3h C-terminal" evidence="3">
        <location>
            <begin position="173"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40794" checksum="9E4F85E008CEA6DB" modified="2012-09-05" version="1">MSTSLASRLAAKQASQNAQALQNSQDQRINLPSYLKDAVQDPSPVEKIEVDALALSKIAKHSSENKNATGICLGLDILSVLQVTNVFQSYTPLINTGNPDEDERKSKILRNQYNSKMCRNLSDVDLDDQPVGIYIAIEFGATINEILLSYAPLLSALGKNKGFVLLYDTSSASKGNLNLRAYKIQENFIQALRTNQFSEKGIIENQLTFSDILQEYPIELKSSSLTKAYLESLSTPKTPTDSTVLSKNSAKILQLDLDSPLQANIDNLVESLDAYKDEQSQLAFANRHLLRERAKVEQNIQKVQQQRQSQNLAPLSESEIQRQFKLPAEPSKLPSLVLQGQLDGISQRLSDNALSSISMTHPDGLSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAA9</accession>
    <name>I4YAA9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959160.1">
        <property type="nucleotide sequence ID" value="XM_006959098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAA9"/>
    <dbReference type="FunCoup" id="I4YAA9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="18474153"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60770"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_3_1_1"/>
    <dbReference type="InParanoid" id="I4YAA9"/>
    <dbReference type="OMA" id="AMWFGPK"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="29"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="614" mass="67571" checksum="35B37C2836CE5C45" modified="2012-09-05" version="1">MAGLANFSPFEINTSHLAYALLGAYIALFMMVSLFIKERLYIGEAVTSTIFGIIIGPYVGAVIDPRKFGGENGNNAEEETINELILEVTRVVLALGVFAIGVELPRRYVKRHWKSLFFLLCPIMAFGWVISAAFIYALIPGLDYIGSLTIAATLTPTDPILAAAVIGGKFAEQHIPAHIKHIIACESGCNDGAAFPFLYIGIYLLLSPMDTPYAVEEWFLITWLYEVALGIFLGALIGYGARKLMKFCESRNLIDRQSFVAQYVSLTLLCIGIALILGSDDLLASFSCGTAFAWDGFFNKATEESNFSSIVDLLFNSVCFIFIGALVPFDQFNDPTLGGITNWRLVIIALCILIVKRIPPMLALYKWMPDIKTFREALFAGYFGPIGVGAVFISALATIQLPHPEGQPANQAELVAVTIQPIVFFLVLCSTFVHGLSIPFFSLSRRVGTTLNAQAGSLESFSKEDSRETSKDDQGGTRNVQSWIEGSNLITERPINNNSNEDDIDVQVHEVDIGKRGNTSDIIDNMENEFKDVGGSVGKEYEALKRAEYEVKLKQDIEKATQSKKKVVLHVHHKPGTRDWINSKFLGRRNSESTVEASRSNSSSSNDKGKQTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAE1</accession>
    <name>I4YAE1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_29152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958928.1">
        <property type="nucleotide sequence ID" value="XM_006958866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAE1"/>
    <dbReference type="FunCoup" id="I4YAE1">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAE1"/>
    <dbReference type="GeneID" id="18471082"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29152"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAE1"/>
    <dbReference type="OMA" id="PCLSWED"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="62"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="381" mass="41312" checksum="96BB69B8A172571C" modified="2012-09-05" version="1">MSNLLRVDSNLDATSQVDMEDYRDDVRIIGYDPLVQPALLQHEIRSTAESQKSIAMGRNAAANIIHNRDDRVIVVIGPCSIHSPEQAIEYAKMLKEKIPQWPGLHIIMRAYFEKPRTTVGWKGLINDPDINGSFKINKGLRIARQLLCDITELGLPVGCELLDTISPQYLADLVSWGAIGARTTESQLHRELASGVSFPIGFKNGTDGSVGVSVDAMRSAAHPHSFMGVTEQGLAAIVKTAGNADLHLILRGGTKGTNFDKDSVQAAEAAIKKARPDNHPAIMIDCSHGNSSKNHRNQPKVISDISQQIRAGNRSIVGVMAESNICEGRQDVPAEGPSGLKHGVSITDACVDFESTVNMLNELNDAVLFRRSQSSQSNGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAE9</accession>
    <name>I4YAE9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958935.1">
        <property type="nucleotide sequence ID" value="XM_006958873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAE9"/>
    <dbReference type="GeneID" id="18471590"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32937"/>
    <dbReference type="HOGENOM" id="CLU_2442546_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAE9"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="90" mass="9982" checksum="0AB1E2E65B6CEFA5" modified="2012-09-05" version="1" fragment="single">MSSPQPPNTQQTQKGARDTARTFNKFAKRDPALYPLAGIIGGIVVVAGFFLTSKTDTTKAERKFANQTWADRLAQEKTNWKTELNTPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAG8</accession>
    <name>I4YAG8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_46780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958953.1">
        <property type="nucleotide sequence ID" value="XM_006958891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAG8"/>
    <dbReference type="FunCoup" id="I4YAG8">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAG8"/>
    <dbReference type="GeneID" id="18472400"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46780"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_0_3_1"/>
    <dbReference type="InParanoid" id="I4YAG8"/>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="216" mass="24584" checksum="6102B7BEC1423821" modified="2012-09-05" version="1">MDGNRRFARLHNMQISKGHEGGFIGLRRVLEFCLRLNVRCVSIYAFSIENFSRSQDEVSSLMDLASTKLDEICQHGDLIEQHNVRISVLGAKQLLNDEVRSKLEMIEKRTAGNDGAILNICMPYTSRDEMSSAMQVSGSDKKVYQKNLMTANSPPLDILIRTSGVNRFSDYLMWQASHQNTFIQVVDAFWPDIGISELVPVLLNWQRLKWSNSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAH4</accession>
    <name>I4YAH4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_69406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958958.1">
        <property type="nucleotide sequence ID" value="XM_006958896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAH4"/>
    <dbReference type="STRING" id="671144.I4YAH4"/>
    <dbReference type="GeneID" id="18475580"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69406"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="I4YAH4"/>
    <dbReference type="OMA" id="NDHAYAV"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="562" mass="62551" checksum="E6B88CF29617798D" modified="2012-09-05" version="1">MEYDYVVIGGGTSGLVLSSRLAERGEKVLVIEAGIDPKNDENITSASNFVTNVGGSYDYGFSVTDTHVPMPRGKVLGGSSAINYILWNRPSKYEIELWHKLGIEGWSFENVWKYMKKAETYIPPSQTQLESFGMQAPHSKHYGSSGPITLSYQRYISPTDRRWLETIKNIGLPINENPHDGENLGANISPITADPNKHRRTYGCTYLDALPTASLDILTQTMVHRIETVTEDGQIRATAVEYCSEGVTKSVKIRKEVVLTAGTINTPQILELSGIGDTNILASHGIKEVLNIPTVGEYRGHYYPTLCYQLNDTVKNMDVLRQEEQIRREEAEKYRKGDPSLYHQAASCVLYLKPAQILTKEELDRLESLLREASSNEELVLAQYFLDERIPQVEIDMVGFFADLNSVPEDGKKYVTFMVGLQHPFSKGSIHVSSSDVNDKPNITSNYNKHPIDRLLLSAAIRFIREKIVTGNPLTDIISKEVSPGRGVSVEEFIENAPACDYHPSSSAKMGNNIDDSVVNSELKVHKTRNIRVSDASIIPLGLSSHIQSIVYAIAEKAVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAH6</accession>
    <name>I4YAH6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_64861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958960.1">
        <property type="nucleotide sequence ID" value="XM_006958898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAH6"/>
    <dbReference type="GeneID" id="18474962"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64861"/>
    <dbReference type="eggNOG" id="ENOG502SBW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156026_2_1_1"/>
    <dbReference type="InParanoid" id="I4YAH6"/>
    <dbReference type="OMA" id="HEYGSTL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="82" mass="9184" checksum="435645D6E11108DB" modified="2012-09-05" version="1">MNAEQHERYIVVFKDSASDAEIKNYAQEVESGGGKIVHHYNPDGIMKSFAGHIPQNVYTSLSAQSGQSPIDFIEKDKEMKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAY2</accession>
    <name>I4YAY2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958801.1">
        <property type="nucleotide sequence ID" value="XM_006958739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAY2"/>
    <dbReference type="STRING" id="671144.I4YAY2"/>
    <dbReference type="GeneID" id="18475562"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69278"/>
    <dbReference type="HOGENOM" id="CLU_593401_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAY2"/>
    <dbReference type="OMA" id="LHWTPCP"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="461" mass="51136" checksum="2AC055BA0C1CBA16" modified="2012-09-05" version="1">MVHEDTSQGTFKLFVKRVWQKNLTVDGLPHLFWNPGGPGIPSGSDPDSGVEAFSDMLYTFTGKDYALVGIDARGTGLSDLKVDCGNDHSSILPDTPPQISGAKEVLFRQQLGEYFASETSYFANCTASSPYLSRLGTYFVADDYKHIQDMLVGRQSLINLFGESYGSFLGQVLAAKYPNRVGKFVLSGIMSPKTRSLKPALESIPDYLTSTDKVFDKFVSSCQQSSSCNFKDITKELVDKLTDSVYNTTNEAILQLYPTRSKVINTIYLTMYAPSNWNLAFGEISKTAAIMNTMGAVTNEQMNNAVAAINCADAFITDFSIDDAINAMKGVYNNVSRRFYNQFLYQSAFTCHLYPRATFTEERITNFSGLALSNKILFLSNAFDPILPLAQAQETVKILGDDNAMLLQIDNGYGHTATPNGVIPDTDGCIQDRLRAYFNGENNQDVYKCIVNDQYYIDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-01-24" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB63</accession>
    <name>I4YB63_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958877.1">
        <property type="nucleotide sequence ID" value="XM_006958815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB63"/>
    <dbReference type="GeneID" id="18472950"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57771"/>
    <dbReference type="HOGENOM" id="CLU_826918_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB63"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="336" mass="38908" checksum="CF0CCAE4CC87ED56" modified="2012-09-05" version="1">MPVDYHLIYGNQGNSLSHFQHLQQPTTLPQVGCKKCAERASKFPLLSLPSHILIRVIKHVDEKNILPLSRASRLLNSLCDPIIWHNFTIPIIRYDQEVYKKTRRIVEVDRLLKFLTSEKARKYIRTLNWCRGRLQIPSKGFHTFVNAQIDALVDISKAVSELPNLISLKLDMRMEISPGYRVGLTNTDYFKLNRKTMAEDTLQSIPTSSSIGELSIECSQFLTFSSIFQDISKLSSVEQLNVKTLGEMMPNLDKLTFTYVGRTIEDDELYDDYWQAFSDLKCNELVMCYYPQIPDSKSFDYKVDDGTERVYLKDFEGEFRLFTTVVTNYSLTMFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBE3</accession>
    <name>I4YBE3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958638.1">
        <property type="nucleotide sequence ID" value="XM_006958576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBE3"/>
    <dbReference type="GeneID" id="18473992"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60504"/>
    <dbReference type="HOGENOM" id="CLU_423478_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBE3"/>
    <dbReference type="OMA" id="WASAKWA"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="123"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72668" checksum="52CB0B73EADD7A60" modified="2012-09-05" version="1">MKCDAVKPTCGACTKSRLDCVYQTDPIDKSATSGAKRKSKVQTLEEKIQSLEDELVRARESPGSKPESSFNGLFNGIENHNSMGSANLILEAAALTNPFYNTSLGVPGWHPNYPSLDMTMHLLNTFFNACPIVAGFLHRATFMQRATLPFTHPDAPPPALMHAIFCSASRHSPRTTNPPIVSPSDPCGTDFQPLFNAPSTTFLEIHAQFATKAIEEETVSNANFNRKAEALKALIVMSHFTHIEDSWAEHYRLNVMCIRGAVALRLHLDKDMTPNRLLLRQPRNDIERECRKFLFFLAYVFDTLYSDISGIYPPNINDDEVFSKLPIKTSDYNNLLPTSTIPEYNQYIDSENFFTRHEADGFHFVIKSSVLLARVNRFKHVCQRNVVKNGLQSANQLSTFMELDNLIMKYRASVPDSWGDSVQIVDGGLDVGIYLAHLVGVKAMMSLHSGFIHDQFSMNRLLSCARIILSTIYRLLGTSWDMSKLPSYVVSIYNHASDVLIAAYLQAIKSGDVVSADSITLELSTIVEVYRRMSTRIPVALTALNKLIKKFTQNSVPVKISDQLKMNQPIVQQPSDFSSQLDFEDLNDPLFEQLVFEANATTINPDYAFQQQQQGQQQVNIAPGTAFTARDELRWMNFDSDDQFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBG6</accession>
    <name>I4YBG6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958660.1">
        <property type="nucleotide sequence ID" value="XM_006958598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBG6"/>
    <dbReference type="STRING" id="671144.I4YBG6"/>
    <dbReference type="GeneID" id="18474000"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60515"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330154_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBG6"/>
    <dbReference type="OMA" id="QEWTYSI"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="751" mass="85660" checksum="518AFB742D40029D" modified="2012-09-05" version="1">MDAGPAGSSKNSDMEVKPKKTRNRQALSCTECKRRKIKCDRQQPCGACTKRHEEHKCVWEEKKVIKPSRTNHPYSDQVAYLQEQLAETQSCLRGLASFLRFSGIPVPNNMFDNMSRLSPPSSAFRMNDLDLEDEETAAAFTLEGIAMGRRPDDDFNDEAALLRRKRTDSVNSLSRRTVKDTPAPFSGGNSAPLYCDPPSVTTSLDQNAGFPFTPKPQESMFMTKGILQYLPNKAKADVLITFYLQHLEWLHKPLHVPTFISEYNQYWQDMSIGFATDNIDPKWMSLYASVLCVSTHFGGEYYYNNDRVFGNPEVEARNEKEADIYYQISRSALSQSDFLINHSLEAIQTIIILGLYLHNKNQTETHLILMSTAIKMAQLMGLSRIPDESAGSETQGNVVEREMSRRLWHSLVFQDSFNASASSYSYAIHVDQMTTSVPANVDDDELIANTAIPFVPDSVWTDMSYFRSKLHFANITRKIVDTLNRDSKGSYEFVIEMDTEYRAALDRIPSFLRLDLTDYDPKVLLMKPCRAWERLMMSFTIHNRLMRLHRGYMIEGYSKPEYSVSTQACVASAKTLLALMKEGRKYNWPASRWWVVLIQCWTASIVILIDLFYTSDVHEAEAKSKEVREALVIFRDIQHVSTVAKKAVLTLDRLLEEDKERRADSTASKKRKISIEGFTPIGLAPNYPGLHGDNTNTTRQQQSMLNTILPVPQSSSNVDNSGDVWENMFKQELGLFQDSSLDFCWKFDEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ3</accession>
    <name>I4YBJ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_64600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958683.1">
        <property type="nucleotide sequence ID" value="XM_006958621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ3"/>
    <dbReference type="FunCoup" id="I4YBJ3">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBJ3"/>
    <dbReference type="GeneID" id="18474945"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64600"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBJ3"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="297" mass="32261" checksum="BE2A2C9324045A4C" modified="2012-09-05" version="1">MSKAVERPRKVTIAKLNKMRRQNHPITVLTAYDYPTGLTIEKTHHNHLNGIDIALVGDSLAFTALGYSSTSQLTLDEMIHHCKAVTRAATTPFVVADMPFGTIGVSDEESVRAALRLVQEGGVDAVKIEGGLKQAKTIEKVVDAGVPVIAHAGLQPQRATQTSGFRVQGKTPKSALSIVQDVKAVEKAGAFAILLEAIPPNLGKFLTEMVQIPTIGIGAGNSTSGQVLVQPDMLGSFDAFKPKFVREFGNVGKVTMEALDAYAEAVRSREFPSIHESYNIEDTQWREIEEFIRSHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC21</accession>
    <name>I4YC21_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958541.1">
        <property type="nucleotide sequence ID" value="XM_006958479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC21"/>
    <dbReference type="FunCoup" id="I4YC21">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC21"/>
    <dbReference type="GeneID" id="18473969"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60473"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_2_1"/>
    <dbReference type="InParanoid" id="I4YC21"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="11">
        <location>
            <begin position="105"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="519" mass="58069" checksum="5C1A08C9D9ED259F" modified="2012-09-05" version="1" fragment="single">MGFSGGLQITDLNDFISPGQECIKPVKETNKPKQEEVAPDAPTTEITIGENGEYYEQNQKLEKAEITLNDCLACSGCITSAETVLIESQSHLEVKKYLSKDNDKKTMIASISPQSLASISASLSSRPSNEVLLRRLRHHLKSIGFDYVFDTTFSRHLSLLEILNEFNSLDSNNRLLLTSACPGWICYVEKTHGELIPFISTTKSPQQVMGSLVKYWFSQRINKSASDIYHVTIMPCYDKKLEASRQDFYSDLYQTRDVDCVLTSGELGSLFDKPINLNESLPNENIVSTEEKLIPHHIQHPGTSSGSYLENIMTLIKQTTPNLRLETHSPRNLADSVEYLLINENNECVFKGSKCYGFKNIQNLVRKVGKEKGLNSGRGAAGRMAGRGRVRTRNTGNPHDSKSLDFVEVMACPSGCINGGGQLKPGINTDKEGHERDWESEGVATDPTKNIEESVRWTTKNWINRVEDIYWTGSEASKAVTLEMLSKISTEMLKELSKEHLRTQYHAIESDTSGLAVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC57</accession>
    <name>I4YC57_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_13057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958234.1">
        <property type="nucleotide sequence ID" value="XM_006958172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC57"/>
    <dbReference type="FunCoup" id="I4YC57">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC57"/>
    <dbReference type="GeneID" id="18470609"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_13057"/>
    <dbReference type="eggNOG" id="ENOG502SBNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154717_0_1_1"/>
    <dbReference type="InParanoid" id="I4YC57"/>
    <dbReference type="OMA" id="LVKLMVF"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7175" checksum="0662496F62A6B596" modified="2012-09-05" version="1" fragment="single">SSITKLLAFSIALVVLPISIYFITLNSIFNGNSTYAAISAALTANVVLMLYVGLAIYEDDDDSNSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC85</accession>
    <name>I4YC85_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958274.1">
        <property type="nucleotide sequence ID" value="XM_006958212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC85"/>
    <dbReference type="STRING" id="671144.I4YC85"/>
    <dbReference type="GeneID" id="18471500"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32493"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_2_1"/>
    <dbReference type="InParanoid" id="I4YC85"/>
    <dbReference type="OMA" id="CIYDRAD"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697693" evidence="9">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="257" mass="28546" checksum="8FF651DA31E1F545" modified="2012-09-05" version="1">MKFSLAIASAILAFASAAPSKRQTEGVVETCDNPNAMAITYDDGPYNWDYNVNDQFNAVQGKTTYFLNGYNYGCIYSEENVSHLRALYENGHQMASHTWGHVHLTQLTNEEIDEQVQLVEDALWKILGVVPKYLRPPYGEVDDRVVQHLQDRWGITVVNWSDDSEDSLGASDDHILGLYDSFAADGSHTPRIVLNHATYDTASRLPQIYVPQMANAGYSLQTVAECLNDSPYKVVGGYSERDDTWTCEGKPLPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCB5</accession>
    <name>I4YCB5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958302.1">
        <property type="nucleotide sequence ID" value="XM_006958240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCB5"/>
    <dbReference type="STRING" id="671144.I4YCB5"/>
    <dbReference type="GeneID" id="18471505"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32520"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="I4YCB5"/>
    <dbReference type="OMA" id="TDPDPNM"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266074" evidence="5">
        <location>
            <begin position="16"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="663" mass="72313" checksum="11CE2C715890A4CC" modified="2012-09-05" version="1">MKLNLLLGVLPIVTATPFHQFKRNIINDANQVNNQTYDYIIAGAGIGGLITANRLTEDENTRVLVIEAGGNGDDVRERIDIPAQAYLDGLPVDGSPYDWAIYTEAQSNLNGRNLHWPRGKIVGGSTAVNALYMTRSTKDQHDAWSELIDDDGWNWDNLLPYFRRFETFTTPKKSLEKNLSIEIEHSAHGYDGGIQISFPQYNYPQNGLWQPTFENLGIDSDNDPFSGQNIGGYITPNSIDPDTQLRSYAASAYLYPIETSRSNLVVLTDALVTRVNFDTSSARPKANGVSFRANGNNDEFQAHATNEVVIAGGTLGSPQILLQSGIGPRENLESQNVNVLVDLPGVGAHLQDHISATVEFSTTAPVGGSLSDSELDEQLEIFREGHFARSLYSTPNGAIAYIPLEDIMGDETSTFLDQLEANMTDATSSGDDPDEVKAGYRATYESDLENVYKAGNAVVEILMNNLGSNLGFQLALQHPFSRGKIYLGSSDTSENAKVDPLYLSHPADIQLIRNGLKYIRRLAATEPISTMIRDEVSPGLGTSSDDDLDDYIRNSAVSQYHPASSCAMLPEENGGVVDSQMRVYNVDNLRVIDSSTIPLPVAAHHMQVTYAICEKGADLIRGYQKASDSPSATDSESGASLSKHFNGQLLIMMMIIASIVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCE2</accession>
    <name>I4YCE2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_51377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958329.1">
        <property type="nucleotide sequence ID" value="XM_006958267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCE2"/>
    <dbReference type="STRING" id="671144.I4YCE2"/>
    <dbReference type="GeneID" id="18472556"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51377"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="InParanoid" id="I4YCE2"/>
    <dbReference type="OMA" id="TAMKERC"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697971" evidence="3">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="349" mass="39574" checksum="70B34794B109A82D" modified="2012-09-05" version="1">MVQVGFLSIAALVASAAAVPAKRSCDKIHVRRDWNSLNGDEKANFLGAIKCMMQKPTISINGVDQVSRFEDYTYIHQYPGYAIHWVARFLPWHRWFVYAYHQELQECGYEGAMPYWAWEQDYQDLSASNIWNADPEIGFGTYGNFDYNNVYNATVVTDGAFANHDINFPFPHKLSRNLPSSANLPWDGPGPYAQRGYNPEAMKNLTNIATYKEFSVLLESPDPLHNPSGIPGSHGAIHLSLSADMASNHGNNSSPNDPLFYMHHSNIDRIWSSWQALDEKHLYDYEGNTDFYWSTGMRSGLPASLDDPLLYGEANALGSENLKVKDVMDTTEWPLCYTYEDLEPWVFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCF1</accession>
    <name>I4YCF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958337.1">
        <property type="nucleotide sequence ID" value="XM_006958275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCF1"/>
    <dbReference type="FunCoup" id="I4YCF1">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCF1"/>
    <dbReference type="GeneID" id="18473910"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60358"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="InParanoid" id="I4YCF1"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="158" mass="18064" checksum="5DE3FE4B3BA55728" modified="2012-09-05" version="1">MSGVARTRLAEERKIWRKDHPFGFWAKPTKFPDGSLNLLIWEVGIPGKSGSAWEHGVYKLNMQFPEDYPSKPPKCKFTPPLFHPNVYPSGTVCLSILDEEKGWKPAITIKQIVLGIQELMTDPNASDPAQVEAYTMFKNDKPGYERRVRQQARENIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX2</accession>
    <name>I4YCX2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_18314</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 14"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958034.1">
        <property type="nucleotide sequence ID" value="XM_006957972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX2"/>
    <dbReference type="FunCoup" id="I4YCX2">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCX2"/>
    <dbReference type="GeneID" id="18470761"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18314"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCX2"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="16">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="17">
        <location>
            <begin position="211"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="373" mass="42459" checksum="1E5CB00651462FF3" modified="2012-09-05" version="1">MVEKFDPTESPHRRYNPLTDSWILVSPHRTKRPWQGQVEAPSKPDLPVYDPKCYLCPGNERSNGGSNPKYDSTYYFVNDFSAVYPQNVETPAEPHPLIKTSPISGRCYVVCFHPNHNRTIAQMETKDVFNVVKIWCDLYSFIPEDEPSVKYIQIFENKGSAMGCSNPHPHGQIWSVSYIPEEPAKALEMQGKYAKNTVATSSTKVSHLTGSPNMLLDYAAFELDKKERVVCSNDDFVAVVPYWAVWPFETLVIPTKKHIPSVAYLNETEQGSLAAILREVACRYDNIFDTSFPYSMGLTQQPIKKEGDADWDSNWDDAQLHIHFYPPLLRSASVRKFLVGFELLGEPQRDLTAEGAAQRIRDSDPTYPRWAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD13</accession>
    <name>I4YD13_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_64087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958157.1">
        <property type="nucleotide sequence ID" value="XM_006958095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD13"/>
    <dbReference type="STRING" id="671144.I4YD13"/>
    <dbReference type="GeneID" id="18474900"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64087"/>
    <dbReference type="eggNOG" id="KOG4541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305277_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD13"/>
    <dbReference type="OMA" id="YLENAEC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="979" mass="109421" checksum="4C13889DB39E2295" modified="2012-09-05" version="1">MEAAIARIEEACRRFTHPATRQQGESELLAINEALSPADIPAVTIAVLEQSTEFYAHFHLLTLLISTISTHSNPELSQHLLNYILNSKKLPVYLSVKAHLALVKATSLENLVVILNGISTSSPAAAVGISRAILEEQQINADEDDQLQISTFENNVLPILSNIILQSLTLSQESDVMKYTVPALEALLTYRNDQNDLIFNTATESMHASVLHQFARPEVLQLIMSVNTYDNETLGFVVRKVLNAVFSSTHPQDKNGWTLTLIKYLETASSMDIGTRLSCHKSLLQSHNLDVILSNDGPTYIQNLFQLGGASLSQQGDIFADFLACWLSILRSIETDTGMIPTDLCTEIVRGWLNTKVTLLDNSQEDDDDDDNDLDDVETELKVILDPLAQLGRMNPIPILEIVIEKVNSFNVLIESSGYLSDSNYDRLQTLVLFTGSLIADEGVGETPSIPNKLVDTEHSAYGLSTLIGSLAKLTTLFTSERDLSPNVAGIIWKSFWARFLRTYGLNDNLALPAMKDINNVGFYSEFQNVIQHSLQKWKAEEDVIDGLAETIQSLPMSSSLINFGNIIDIILSNMPDWPYKLDKKLVSSCGIYISRMDRNSEERQRYKISIFYFISNMFTVIDDEGFKTNSQKHPYITHIKMGLNALVGLSETLDPYTYLDTVEFIKQVLSKLLGVVQTHYLSRIDIQLDILCIFNSVIQNLDLGMDFDEAGLRTLPEHYVAPVMNMWFEYYLSIKYERGVDDSDEFSEGVEIIFNILRNLASTDGNYSDINNDKTFAAFVFSYLDPLFNISQSILESNLKLQAISVDLVCNILRSYPRSINMQMVSTGVTFSNATLLNFLNQVITSQWSSSHTLIDGVESYMKYGSEKNGNGGKTLSQVIAIPLNAILLRTVISRNLRQRLVIFILSVLNTTDVHAWLDRKTVLLTITNNLKCPESSKDAIQASLQSALMSGIDLTTYKSILNELSSQVANIMRGVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD79</accession>
    <name>I4YD79_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958214.1">
        <property type="nucleotide sequence ID" value="XM_006958152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD79"/>
    <dbReference type="FunCoup" id="I4YD79">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD79"/>
    <dbReference type="GeneID" id="18473872"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60301"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD79"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27326" checksum="C3595563D79A3C64" modified="2012-09-05" version="1">MILVGLLRHYVVQLLGGAPKKQDIKSIREQRSLMRSAILRQNGKVLTNTAFVKRKQYLIESFKDGKYLKVAPPKEGDQPQLPPNPLSDPDQMDNMMDGMKKQMVMFIPQTVIMGWINSFFSGFVLIKLPFPLTRGFKAMLQRGIMTPDMPASYVSSISWYFLNLFGLNSVFKLLLGDGNKTDSVRDMQSLAALSGALNQSNPMQNQDMNKVFKAEIDNLELSDPKFITNDVEIRVLKKYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDI6</accession>
    <name>I4YDI6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_17851</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957748.1">
        <property type="nucleotide sequence ID" value="XM_006957686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDI6"/>
    <dbReference type="FunCoup" id="I4YDI6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDI6"/>
    <dbReference type="GeneID" id="18470741"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17851"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDI6"/>
    <dbReference type="OMA" id="EDEYVIM"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="965" mass="107112" checksum="8660559B9E1AB0A5" modified="2012-09-05" version="1">MKLLTASFSLFFVLHLAGLWLFSRGFLLNRVTLNDISNLDNTAPDSTHSKAVILIIDALRHDFLLPQNPSNPLYNEHYHNTLTLPSKLTRESPDNSLLYHTYVDPPTTTLQRIKGLTTGSLPTFIDIGNAFSGTSIEEDSLIRQLKNAHKKTAFVGDDTWMSVFPDSFDEQFPYDSFNVEDLHSVDNGVTKHIFPLIANNTDFIIGHFLGVDHVGHRVGPSHETMSTKLKQMNDVLTRVVEAIDDDTLLVVMGDHGMDSRGDHGGDSELETSAALWMYSKQKPLTNSKARTFANSLPHHQGHRTIQQIDILPSLSLLLGLAIPFNNLGGIIPELFPIPSVLRQAQDVTSNQIWKYLKSYAKGQSGHEIKPFLQSLQQKLNLAKEAKSLEEGSYFNKDHTSYYLYSDFFNSTLQSCRSIWAQFDALLMLSGGLLLLMSLPILVGVFNRAGRNSSCDWMKVAVRDAQKAAPWALVVASFFSIALLKGKHIESIIFIICFAVELALSYAVPPLSTPKALDLFGILSHLAIFLSNSYVLWEDRVLLVILQTPILFSLVRAPYANQARMKKQLAIASALIAFTLRLMAGSTVCREELGGWCAVTFYETSSSSLSPAWVYATLIPSAIATYFVLRYSLNVSASFAGFAGIFVGGFTLSLVLGSSYWLLDLLEMKTPSYVLITIKTTLARTNILFAGVVGYTFWYVSTLCIDIKEENRQDGKREVKVLGFSNSYGAYYLLFMLPAFALMWLTNLPTGQLALFGCLIVILVFLELTDYQNDEKALNKLLKRPSKYTKKDGKMVAPPQPRPALWRSAWLAQLGYLLYYSTGHQAVLSTLQWKAAFVGFPKLTYPYAPLLVSINTLSGFILVSLAVPLLVYWKVAPKVNASQSLNTNILRAGSGFVLYNTLITLATLIAAAHFRRHLMVWKVFAPRFMLNGLALLATDATLLAAISLGASITSTKVSRVFKTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDL6</accession>
    <name>I4YDL6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_45184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957862.1">
        <property type="nucleotide sequence ID" value="XM_006957800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDL6"/>
    <dbReference type="STRING" id="671144.I4YDL6"/>
    <dbReference type="GeneID" id="18472355"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45184"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025520_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDL6"/>
    <dbReference type="OMA" id="YQTTRRH"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="47735" checksum="1A2B4C498CBE7BF5" modified="2012-09-05" version="1">MKQPSTPTGHSPAYLTSRRHSVYGTETKIVIDPGSKVIKVGFSGEASPRECIMIREILWDLDGIQDELGVLDIFRDIYFEQLQTDPKQRRVIIAENPLLSSPVKFAIMSVLFSNLQVPSVSFTPSPLLSLISAGRTTGLVVDIGYLQTVVSPVYASRPLDPHIMTTSFGGKYLSDRLRELIVEYATYYPPFTTQQLSTATSQPPPSTIPQDAITDAWIEDVKCKALFAEPLLRKREDDDEVMSESDDDASQISVKLQTNNGRGVVFIPGWIRTKVVEDLFDSKEDIDQPSIPECIVKCLQKLPIDTRRDLAANCLVVGGTASMVGFRTRLKNEIRELLTRSSETKKSLMDLSGLSASFEVLNDPIPSQASQPTDETTNRRKSNKVNMKAPAWNPSCYAWVGASLSGSVKLSAPEIQRNEFEESIEDKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDN2</accession>
    <name>I4YDN2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_63814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957878.1">
        <property type="nucleotide sequence ID" value="XM_006957816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDN2"/>
    <dbReference type="FunCoup" id="I4YDN2">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDN2"/>
    <dbReference type="GeneID" id="18474871"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63814"/>
    <dbReference type="eggNOG" id="KOG1463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029573_2_1_1"/>
    <dbReference type="InParanoid" id="I4YDN2"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000007">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="206"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="403" mass="45439" checksum="9D1FEFE684B17992" modified="2012-09-05" version="1">MSTESTTELKQILSENATTDADLRKQEAALVKLGEIYRDQQNAAELTNVIKSSRSFMSSTAKAKTAKLIRTLIDHFDHIKDSRDAQMDCLIDNINWAKSDKRVFLRQSLEIRLAGIYYASKDYKAALSLLDGLLKELKRLDDKIILTEVHILESKIYYSTSNIVKSKAALTSARTAANAIYCPPLLQAQLDLQAGILHANDRDWKTAFSYFFETLEGFSSQDDPRAVSALKYMLLCKIMLNLSEDVDAIIQNKMAQRYAGTNLDAMKAIAQAHKNRSLIEFEKALRDYKQELSADQIIKSHLSSLYDTLLESNLLKIIEPYSKVEIDHIANLLSQPINAIEQKLSQMILDKVFYGIIDQGNNCLIVFDPPQEDHLYDTTLDTLKNVTQVVSGLFEKTAALQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDS4</accession>
    <name>I4YDS4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957918.1">
        <property type="nucleotide sequence ID" value="XM_006957856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDS4"/>
    <dbReference type="FunCoup" id="I4YDS4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="18473790"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60173"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDS4"/>
    <dbReference type="OMA" id="WNYLDAP"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52561" checksum="2FC099B6B6644C20" modified="2012-09-05" version="1" fragment="single">MSSAEEHTNLHATENVAEAGDEGKFKTLTNILKKCMSVKDIANIRLSLPASLLYPAGNLEYWNYIGRADTLVDINQHDDPLDRMLAASRFCFAKDLRFVRGGIVKPYNSVMGEHFRCSWPATVPELNEKGEFIPTSDLVNDYDDASGASSRTTTPAPQGPGVAAQDGKNVHAVSRDLRTVAALNNRRSKGKVSFLTEQISHHPPVSAYWYSAPDCQTEIYGVDQVSAKISGTSIKVQPGERNKGLFVNLKDRQEEYHISHPTALVSGILRGLSSIYAVICDSSVIEVNGPNVGDNPLRLIIEYKEESWIGKPRFLVEGVIYHATTEESRTWTKVKQVPRDQVLATLEGTWRTKIYYKKAGEDEQKLLIDLENLDLTPKYVRDLDKQDDLESRKVWEPVTRAILEKDYTEATKAKQVIEQHQRDLANERKRTNAAYQSCYFELDTPDGKPILTENGKRALESELLADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDZ9</accession>
    <name>I4YDZ9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957986.1">
        <property type="nucleotide sequence ID" value="XM_006957924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDZ9"/>
    <dbReference type="GeneID" id="18475444"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68642"/>
    <dbReference type="HOGENOM" id="CLU_1361367_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDZ9"/>
    <dbReference type="OMA" id="FWHKSAA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="23268" checksum="D9009F1927BD5DA7" modified="2012-09-05" version="1">MFEKVVDIVKSANGVHTKQIYKQLNADVGSMTQLKQKLLKNLENNHKIVKKHSLRLEKVNSSQPLPKLSNKSNLVTLPDGTKAIAHSQWLWYTPESTPAQFSEASTDNLHNVLPPHNSMRAEKKQAHLDQVKFNRENREVPKVAPPKDLLDGFQAPSELHTSVKDGLSRHRQQQKVVKNLKYWQKVAGKVSIAEEAFRKGQESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE52</accession>
    <name>I4YE52_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957508.1">
        <property type="nucleotide sequence ID" value="XM_006957446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE52"/>
    <dbReference type="GeneID" id="18473656"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59967"/>
    <dbReference type="HOGENOM" id="CLU_2063303_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE52"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="119" mass="13420" checksum="25DA9A90E8D66400" modified="2012-09-05" version="1">MAYCYPKIIYYAIIFQTLIIIYNLVLKWPSNDCSPVERTVDDIIWRYHTEGECRRTTQSETIAEAMLKKLRASDSVCTAACMKKVHNVNWNGFLIMTDDPLGEALSICGEAGTQTCTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH7</accession>
    <name>I4YEH7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_17124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957478.1">
        <property type="nucleotide sequence ID" value="XM_006957416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEH7"/>
    <dbReference type="STRING" id="671144.I4YEH7"/>
    <dbReference type="GeneID" id="18470723"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17124"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002523_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEH7"/>
    <dbReference type="OMA" id="LFEMEPV"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="269"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1171"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1263" mass="143059" checksum="1A5388AA964C0A45" modified="2012-09-05" version="1">MVHEPGARVSTSAGNGTVRFIGNTEFAPGVWVGVELDSQTGKNDGSVAGKYYFESKAGFGLFVRPTQIRDAPKRSVPSSTPSSRQSTSSLRPSISSRPSSNASSIASTPVTTRTSSAKPPPPKSAPRRSSIALQTPKAVNNTTGNTLSVNRRPSIVQTQPRLNSQRTPSISSRTKIVERPPSQNDSLDFDDNDSPLLPTIPLPQEFADELKPQDSSSKPRLSNGSANIKGSLNYSNQFDQNLPVSPSPPKRTLDQTVSKWELEEFKAKLKISEQHREADQSRLKELESQKEQVEQFNIIKPKLQSKIAEMQTEIRDLRHHNKDLVEQNEQSKQQNQEITDLLEIATLDKEIAEEKADNAIIELEAIQEREVDLETEVEMFKNKLEEMHHNGTTDVMKVENGQDVSLASQQLTKQNERLKLALIKLRDVTNENETLHKERIRELEREVRDLQGMQDEFDNMHRKLQDSEVYVDELKQHLDDSLASADLVEHLTENNLTLTEQVETMKGTIEDLEALKELSDELEESHNDTEKQMQEMLDYKELQLLASLKRIGGLIEATTDYENTILQFREHMHLLQSDLEQMRQTQLEQATESEALTTREQAMLSLNQKLQTTAHKSQAKAIDLDLRKLDAAQASEHLRIVQNYLPITFFESGDADSVNGLLFFQRCAFKSDILNQVVAQMHGLPNSLYDSVPEILVGVCELRSKITHFAAINRRFAAMVKRCPVDMYLRMGKIANEVKGTEKRIDHWIELLRREEFREFECTKDIIMLLGQFEHLVDLYLNDTQLDLDEKELDSVLAIDCDLDITAAAIGLSKQMIIGIDTNDSLDKEIGQNEFARDFFEPLQKVLNTIKSIKFASRKFVARIETCIRDSSAIDPQVSTQLSVLSNQTAKLNNFAVSFAQDLNIYINSIRETNDAFEFTKIIEFVNNAAQALNIKDVTSADGWNRVDDFVDAFAETFNNVLQTSLEPDSIVKLISEEPWLVRIEEFKSVTNHNIEAERAVSKLTNDVKELVREIRNKDQTLQESSVKIEVMSKKLDTVRKQTEILESMEGEVSRLKKQEKTLNDALDVLQNDLNNVEQENDTLKQSATKIDQTQGLNTPMSTAAIEGLVGNEGSLDKSVLIEKIDSLMSIVKYLKSENSYLKSRDRLSTLKSLKPLTMHRPPTPTLLTDSENDSDSDSGEESLPEKPSVHELSVQGRSITYKLVDHLASKKVVDLSRLKQGQVWQRSDCKPEQQLYKSQNESRKLIKKAEAFLQDYQSYRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEK5</accession>
    <name>I4YEK5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_68368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957646.1">
        <property type="nucleotide sequence ID" value="XM_006957584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEK5"/>
    <dbReference type="FunCoup" id="I4YEK5">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEK5"/>
    <dbReference type="GeneID" id="18475382"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68368"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="I4YEK5"/>
    <dbReference type="OMA" id="VYETNIW"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31002" checksum="FA3B9378E42A3C09" modified="2012-09-05" version="1">MTVVLITGCSQDGIGEALASSFHRAGCHVIATARNAAKMGRLTDAGIMTMELDATSDESVNGVAKKLKDDGIVLDILVNNAGIINNSPLVETSLDVAQKVIDTNTIGTFRVTKAFTTDMIQARKGLILNVSSVVGRMPLPFGGFYAISKSAINTMSIVLRSELEPFNIKVMVLEPGAVKSNIVNNQAGGYEPSDDSPYYPIKDLIINRLQLSQIHSTAPGRDVFADDVVRHALQKSPPITLITGGKAWLFKVLTHLPISWVQWLFSHRFGLKKLKNIVSNESNKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEL8</accession>
    <name>I4YEL8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_17226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957481.1">
        <property type="nucleotide sequence ID" value="XM_006957419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEL8"/>
    <dbReference type="FunCoup" id="I4YEL8">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEL8"/>
    <dbReference type="GeneID" id="18470726"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17226"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072366_1_2_1"/>
    <dbReference type="InParanoid" id="I4YEL8"/>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="190" mass="22003" checksum="067ACA0C990AFCF9" modified="2012-09-05" version="1">MGNKSSKLPPQDLESLIKETYFDRREIKQWYRGFHKDCPSGELDERSFAEIYKQFFPFGDPSSFSKHVFKVFDTDRNGRINFKEFLSALSVTSRGKLDEKLKWAFQLYDIDDDGTITYDEMLTIVRSIYLMSGTIVKLPEDENTPEKRVSKIFAAMDKDKNSSLDFDEFVEGSKKDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEW7</accession>
    <name>I4YEW7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957182.1">
        <property type="nucleotide sequence ID" value="XM_006957120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEW7"/>
    <dbReference type="GeneID" id="18473559"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59799"/>
    <dbReference type="HOGENOM" id="CLU_671223_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEW7"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698061" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45599" checksum="BB5765FDB06FC3CB" modified="2012-09-05" version="1">MRFIFLSTLITASLPFARSDFGFEVRNNIECGRLEVRYSGANGSPDILVVCLIFHKIAHILIKHQLPIDGDVAKAPMIGEPTNMSPGSGVYVNNEFRMPAGVHFTVTMGDDDGMGTGGTSEILRVQDNGNGQGCFRKNQVTTYYEIASNSSNWNSCDTLSLNVIDKSKTKATDLIDYYAISPNSRPIHIQSAHINDTVEYQLTQPEQSQVMIFSLYHGTNLAMDLGGHTNMYRIGEGSTECNKPLEASPTAAQNNSSGSTNSGGISRGAIAGAVVGAVVGGAALAALVFFLLVKYKKHSNARIEYARKLESDIEHRDPNEDIDDMGEVVPFTQDNSHQNTSNQGSSTYSPVSLTNASTHSPYTPIHPSPQSAPLNRVPKLHRDAGPAVRNGEEEMEADVPPTYEDASRNESHNREEYGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF45</accession>
    <name>I4YF45_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957257.1">
        <property type="nucleotide sequence ID" value="XM_006957195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF45"/>
    <dbReference type="STRING" id="671144.I4YF45"/>
    <dbReference type="GeneID" id="18472852"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56783"/>
    <dbReference type="eggNOG" id="ENOG502S2VV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034021_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF45"/>
    <dbReference type="OMA" id="EERIMWW"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="444" mass="52174" checksum="256B344EAA5BAF27" modified="2012-09-05" version="1">MTATLIETQAKTSWLFNSRRLRVLFCAILLSLLWFFLDDYSREEDSATYRASIAAIPQARTLSQHKIVDSNSCQDPYSKFGRLQVDLQTKQENVWIPYDKDCQPPRLMASLLNNLDLDNHWSPASSPSTHSQDFEDISFVKNKTVLVVGDSIARETVRYFCELLGEDVVNLNDDHPWSPFKEYTSGERTRRRAPRESSLPNVCYIPSIDFMIIQMFHFGLDQEEFFKDKEQYNPPNNFEDRLKVHGRDVFDYIHNDKNPPEMFEGAVPRKTPKPDLVEVSSTLWDLARFAKIDINKNTSTLTDLEEDRLDFYMNRMTDVLDTTLEEFPDSQLVWRTSHYPSDCNNNKLDWIGRDLARLEQEREHQNKPYFHSNRLFQLEQATRHVLSQPDYQDQVRINEWGHLMFGQHAHQIDQLHPSMLPGGWLWGDTMLYELRRAVELASYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFI1</accession>
    <name>I4YFI1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SIR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_31899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957384.1">
        <property type="nucleotide sequence ID" value="XM_006957322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFI1"/>
    <dbReference type="STRING" id="671144.I4YFI1"/>
    <dbReference type="GeneID" id="18471387"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31899"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022276_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFI1"/>
    <dbReference type="OMA" id="EENCSAY"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="11">
        <location>
            <begin position="248"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="344"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="651" mass="72345" checksum="E6EC8235DB22F602" modified="2012-09-05" version="1">MGYVNSVHYMEDSDLIISGGSDSRILIHDKGRAEKPLESLLEHWNNVCCLDTRGNTIASGSWDLTARVWNVAGGHYEQVSKLDKHDAAVWDVKLLPDGSLLTASADNFIRHFNPDGSLNRRFEGHTEPVRALAILDGTSFFSASNDGTIRKWNLKTGEQIAVLPGHSSFIYSLAILSSPDGEDYLVSCGEDYEVRVWLGETCLQSILIPAVSIWSVSVLPNGDFAVGTSQNLIHVFTTTEERKANLNILEEWDAQTNEIKDRQTGRSATNKKATEISPIVIDIDVDDDKPNLQLTYNVGEDVQEVAEKFVQANDLSENYIQRIAQFLAQATGQPEVQKSVKEEPKAEKTPIKRLAEILTSNETKKVIIMAGAGVSTSAGLPDFRSPNTGLYANLQQYNLPYPEAVFDIDFFREQPKPFYALAKELYPGSFLPTITHYFFKLLENKGLLKRVFTQNIDTLERVAGVSDDLMVEAHGSFAKARCVSCKELSDGEYVKSCVMRSEIPVCQEVGCADDKNAFVKPDITFFGEALPRNFFDKLDDDFNHCDLLIVLGTSLKVNPFASLISFVGGDTPRALLNLEQAGVYEGGGFSFDEGSRDIFCKGKVDDVVVNLAEECGWKGELMELYETERQEKAKEFNLIDSLTEDLSKIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFJ5</accession>
    <name>I4YFJ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">WALSEDRAFT_36811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957396.1">
        <property type="nucleotide sequence ID" value="XM_006957334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFJ5"/>
    <dbReference type="FunCoup" id="I4YFJ5">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFJ5"/>
    <dbReference type="GeneID" id="18471982"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36811"/>
    <dbReference type="eggNOG" id="KOG1159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="InParanoid" id="I4YFJ5"/>
    <dbReference type="OMA" id="DSIMGLH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="212"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="417"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="510"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="518"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="593" mass="67311" checksum="7F3F6DF50F763194" modified="2012-09-05" version="1">MTYLDDQIKNLGLDDADERELVIVYSTETGNAQDIAERLHREAERWRWMVHVYDVEDFDVNTLLNSPIVIFVVSTTGNGEHNKSFRPLWRLLLNSTLPADLLEDLTFAVFGLGDSGYARFNWAAKSLSRRLQSLGAQMLVPRGDGDERHYMGFDGVFLPWSKGLFEALQVVCPLRDGLERLPDDYLPAPRVGLRFLPGEEAQVKDDKPTAVEGSHQCTLRRSDRITSEEWWQDVRHIILDKPPSLTYDAGDVAVLTPSNNPDAVDELIRLLRWETHADTPLKLTGTVPHRLQEYINRPTTIRSLLTYSLSPFSVPRTTFFEFLAHFTSNNLEKDRLREFLSVEGADDLFEYCTRVRRTAAEVLADFKSVRVPVEYILDVFSVMRPRKFSIAGLHPTKIELCVALVKYKTKLVKPRQGVCSTWIESLAEGATIDISVEEGTIHAPKDPNKPLLLVGPGTGVAPMRALVQKRKAMGASHTALYFGCRMSAMDELYAEEFNKSDELVYKIAHSRDDKEGNKEYVQHILQKDGKRVYNWLIERAGYLFISGSSGQMPKAVKKAIGSIIERLENIPNETAMHTVEQLEKQGRIVEECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFK6</accession>
    <name>I4YFK6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957406.1">
        <property type="nucleotide sequence ID" value="XM_006957344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFK6"/>
    <dbReference type="STRING" id="671144.I4YFK6"/>
    <dbReference type="GeneID" id="18473625"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59916"/>
    <dbReference type="eggNOG" id="ENOG502QRQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFK6"/>
    <dbReference type="OMA" id="WGVAYIR"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="34"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="458" mass="49653" checksum="C08C12EBB34F446D" modified="2012-09-05" version="1">MAPSDIEKKDIELAKKLSDSDSQLDDGSIKEKSLTWPQASFLLLLEYIVIALLALPSSWATLGYGGGTIATIVLGIVAGYTQHVLWRFCLKFPEVRDILDVAVILAGGGKWGRIAWFCAFVGLVLNNVAIMGLHVVQFSVSVNTLSEGAKCTQVFAVCGTLLMFILSLMRELKQMSLMGAIASSTMLLCIVLAMIFAGVQGLPANHSGGPIILKPWDEEGGVEGLIAGNNAALNIAYTYIGHILIPSFVADMKNPKDFDKAIYVSIIAEIILFSLAGGIIYSQIGATDMTSPAYGSLQPHFKKAIAAFVLPTVVIVGGVYCLVTAKTVFARVFDFNSVHRRSHTVKGWSAWIGIITVLWILAYIIGQAIPFFNDLISLISSLFDSWFGFIFWGVGYFFIYRGKSFSRWGIVEGPLNILMIIAGFVLLGLGTYTSVESIRESYASGSIKSPFSCVNNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFP3</accession>
    <name>I4YFP3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_4520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957151.1">
        <property type="nucleotide sequence ID" value="XM_006957089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFP3"/>
    <dbReference type="STRING" id="671144.I4YFP3"/>
    <dbReference type="GeneID" id="18472357"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4520"/>
    <dbReference type="eggNOG" id="ENOG502S3RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124044_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFP3"/>
    <dbReference type="OMA" id="ATYEINF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062122">
        <property type="term" value="F:histone H3K37 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009207">
        <property type="entry name" value="SET7_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022536">
        <property type="entry name" value="A612L_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="116" mass="13353" checksum="BAE6069A652E3357" modified="2012-09-05" version="1" fragment="single">MRILSTSNRGRGVFAGEPIEKDTLVEISPVLLFNKDEYANFGKHTALDEYTFIWPDRSGRMGLALGLGSIFNHNRIPNVTFSINTKNLTIEFKTTRFINKDEEMFISYGSESKLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS3</accession>
    <name>I4YFS3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_59632</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956868.1">
        <property type="nucleotide sequence ID" value="XM_006956806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS3"/>
    <dbReference type="GeneID" id="18473466"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59632"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFS3"/>
    <dbReference type="OMA" id="IMQAKPA"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="130"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="355"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="539"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="959"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117561" checksum="E70A12DDD56C8D58" modified="2012-09-05" version="1">MNEDGDDVVLDPITLHNVEAKDTTKEEYDYVMRRLSGKANIADDNFISKPFPPTHSSQEFIRENFPTILKEFGIYTAILSIIPLPIPLIIALTACLLWRIWWHLDNEADKLVYEQERQRVLNSKASIGGIQESCNWMNQILSRVWGIINPDLFTLGIDLLEDTMESMLPSFMAGFVNGVKVSDMDQGTVPMRVLSMRDLTDAEMMETLNNNDEEKESDSRARPDEESGEYVNLEINFAYRAKPSGSLASKSRNIHMLIHFVVGLKKMLGAVMPVYVEVQGMTGTLRARCQLIPDPPFIKNTTIAFMGLPKVVISATPLTKHFLNAMKLPLVSQFINSSINAAMRDFCAPKSYTVDVQDLLLEDDVKRDATAIGVIDIRIHGAHDIEKSDTNGTSDPYCTISFSKEQKPVYSTRVIVNDLYPTWEESTTILLRPEIIKSQEDIIVQLYDSDRFSADDRLGAATMSITKLVRHPGKVYRLNSELAGQVHGTKRQGTLSWSVSFHPKRDLNKSLLTPGTHPGVPEDIAKKYKDEFGDHKLENENRLVQRIKPEPDFPSGILSFQIHSISQLEVKKITGSFGTDSMRSGVAGQSYMETEDEESSAAPSSYCIVIVNDQTVYRTRKKPFAFNPVFNAGTEKFIADWRSTVVCVVVYDSRYREEDPILGVIPLKLSDILRNGCQLTNSYPLIGGLGYGRIRLSILFRSSDMKLERPLLGWEIGTVQLHSNVVVKFNEGMHVNYNRCIIRTISSEVKLNKRKTTAVDTVAWKIETDEPPMRLPVKRRYASSFRLEFYTNSRVGNTPAAVAIIWLRDVVDNEMLRNFRMSLWEGKDFHRLMQCYTYTEEDAERLNLKKIGYVELDIRYKSGLGKTHSHFKGNKESMDVLQAWEAAVSSGQRSTVGDFINEYTDVDRNRDPARAVIGGADNSSHRTSHRYSTDGYSVGTLGTFGEMSGRMSGRMSGDFGEYETDHEEDGELNKHARHNNKSSKKAIRKAMHREHRGSYQYKPIRTALWAAKGMRHTASNIRAKASLHDRRADQVETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV0</accession>
    <name>I4YFV0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Chorismate mutase</fullName>
            <ecNumber evidence="3 12">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_15919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3 12"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956850.1">
        <property type="nucleotide sequence ID" value="XM_006956788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFV0"/>
    <dbReference type="FunCoup" id="I4YFV0">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFV0"/>
    <dbReference type="GeneID" id="18470682"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15919"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057757_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFV0"/>
    <dbReference type="OMA" id="FLDWALM"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="13">
        <location>
            <begin position="135"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="253" mass="29286" checksum="D5F0934D1785B68B" modified="2012-09-05" version="1">MTTSLLDLNSIRSVLVRLEETIIFNLIERAQFSHNERCYQPGAFAEELPDWKGSWLDWILLGTEEFQAKARRYQSPDEYPFSNPKDLPEPVLPPLEYEKILHEPAIINVNDKILKFYTQDIVPSITKPADDLNYGSTATRDVETLQAVSRRVHYGMFVSESKYRENVEVFNEAIRAKDVKTLESLITKPEVEAALLKRLERKARHYGQDDTENGSRHDMKVDPEVVVRMYKDHVIPLTKVVEVSDIDFAQTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFX4</accession>
    <name>I4YFX4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956915.1">
        <property type="nucleotide sequence ID" value="XM_006956853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFX4"/>
    <dbReference type="GeneID" id="18474795"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62883"/>
    <dbReference type="HOGENOM" id="CLU_894888_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFX4"/>
    <dbReference type="OMA" id="PPAEYKQ"/>
    <dbReference type="OrthoDB" id="10655635at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34985" checksum="CA4EF87578A583CA" modified="2012-09-05" version="1">MELKLKLESGDTIPISDNQKIGRKLFKDYPQSKTISKNHGQIYLDRYLVMYEDLGSLHGSYIIKDGKPSKITPYEPLEIGRGVKLQLAKHLQAHGGRYKPMTFTVEAEPDFRSTSFSARFSDIMDSDDIEEVSSNKQSDNKKPLVEKVDSGELSDDSELFEPSSVLNPAPGYTASDYASDSKESDNNVDSELDERLNELECIIAEHDGSLEKIDNSMRQIKVQSFKNAIIYKRLQVAKRKDAFRSAKLKSNKLKKARKTTEKMNEKMTEKMTEKRIEKPSNYNQSLTAGIIGGAIGVSLGAAATITFLLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG02</accession>
    <name>I4YG02_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_67781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956942.1">
        <property type="nucleotide sequence ID" value="XM_006956880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG02"/>
    <dbReference type="FunCoup" id="I4YG02">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG02"/>
    <dbReference type="GeneID" id="18475298"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67781"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565253_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG02"/>
    <dbReference type="OMA" id="FMEPNIE"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="483" mass="54385" checksum="3B3BDA0CE62C8646" modified="2012-09-05" version="1">MPSDRNIARALKIPPFINKLYSIVNDASTDKYIHWSDAGDTFFVPNPEGLAREVLPRYFKHSNYSSFVRQLNMYGFNKVPHVHQGVLQSDGSSTQELWEFTNENFQKNKPDLLVEVHRKVSTEKKGVGIKAENEQQLTSYVDPSTSAPQSSHSNQTIDVGTIMAGFTQIQKQQAYISSALLTLQNSNQRLWQEAIAARERHRHNEETIKKLLQFVSQVYAQDITPANASTNIFEDLPQDSDMQLALIPKKRQHLMLNNQSSDKDAEEDISRFTHISPESQSSPATGGTEFVDSNGSLNDQKPKITIPEPNKDGFDNSKSLISPNQLDLSQFANLLSPRTSQRLINGNDYMSYNPTSYLPNNEVGSLNENQIGTQRNQLNDLSYDLDALQQSINNVVNNIGLNPSQANEILNASHNVSDSQEMSDLIKNYDLDLDSLLNNMNNETPPTKNEDTNEKKSSSPPPFNFVEEATDEQNQPIAKRQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG10</accession>
    <name>I4YG10_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_43758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956950.1">
        <property type="nucleotide sequence ID" value="XM_006956888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG10"/>
    <dbReference type="FunCoup" id="I4YG10">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG10"/>
    <dbReference type="GeneID" id="18472304"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43758"/>
    <dbReference type="eggNOG" id="KOG2165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007149_4_2_1"/>
    <dbReference type="InParanoid" id="I4YG10"/>
    <dbReference type="OMA" id="AFIEMFS"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="231"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="459" mass="53077" checksum="7F577FA3CB20CF5C" modified="2012-09-05" version="1">MLSAEILYDEIENEVLANKGQWEEPVLDNLRKWIAYGGISVKMQSIMSKEPVKRWADTWLQRFDFFACEKFCEMRIEELFDIIVDYPDSTAAINDIKTCLERVQYRSHLVKQLKTLNESRLLHAGASTQLILTQYISTIKCLLIIDPTGVLLASVAEPIRKYLRERPDTIRSIVASFVDEESELVEEGDAQDNAPIVLENDDAPDWEDPNWEPEPIDAGPNFRSDGRKDLISTLVSIYDSKEVFVEELQVMLAQRLMSLKDYNLEKEIRNIEILKLKFGETTLHACEVMLKDVADSKRIDQNIRSQIETVIRPIVVSRQFWPEIEDFSFNLTEQMQTYRKQYEDAYARFKPDKRLHWIPQIGNVSITLDLEDRTLNLDVTPFQATVIDLFAVNGGKMTAQDIEEQLEAPNSVIVQDTLAFWIKKGVLKEEKLRDEDIAVYRVLEQYEATSPKSKPRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG11</accession>
    <name>I4YG11_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59676</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956951.1">
        <property type="nucleotide sequence ID" value="XM_006956889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG11"/>
    <dbReference type="FunCoup" id="I4YG11">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG11"/>
    <dbReference type="GeneID" id="18473494"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59676"/>
    <dbReference type="eggNOG" id="KOG0926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_0_2_1"/>
    <dbReference type="InParanoid" id="I4YG11"/>
    <dbReference type="OMA" id="FCYLDDK"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="336"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="543"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125286" checksum="980EA57C9D776BE4" modified="2012-09-05" version="1">MRKQLESEQEGKISSKKRKRLDAFITRQLKKEERKELIDKLSKSQSASDAAYLKSSANLGSRLQHTAEDKIALSEHLAVKSAMKKAGSRNGPAESVDDQSHSDSEVSDDSDDEISHPIAKPEPTKEQERIISTKKKAAVVDDKAQMQQPTQKPTESTLGSALGAGGVTPVIRPRKKKTKTIPALTRGWKIPSKEEEPAESERESDSSFDSSASESEEDDEDNKDHSEDEEMSENDRSDEEEPQTERGQKFKEWALRQMNDDAEPKVDEVVTQIPEHYKKSAGPERALADKIELPSHSLLQESDDASIVRTVPIKRSEELQTSRLLLPVVELEQEIVETVLLNPITVICGETGSGKTTQLPQFLYERGFGTKQSLNPGMIAVTQPRRVAAVSMANRVGEELGVGSPKAAYKIRYDGNTSPETAIKFMTDGVLLRELANDFLLTKYSVIIVDEAHERSVNTDILIGVLSRVVSLRNNRWKKNPEDIQPLRLIIMSATLRVSDFTENKALFQQTPPVINVSARQHPVTIHFSKKTTPDYVEEAMNKTIKIHKKLPPGGVLVFLTGQGEIETVCKKLRQRFGKKTKSKSESTNNKLRSSNPAAGDVEIEDVDFGNDDDPALDIDDDLDEEVDSGDESGFEEAVEEETSSAMHVLPLYSLLPSEKQMQVFEPPPEGTRLVVIATNVAETSLTIPGIRYVVDSGRAKERSYNPQNGMQSFDVSWVSKASAAQRAGRAGRTGPGHTYRLYSSAVFENHFEQFAKPEILRMPIEGVVLQMKSMNLDVVDNFPFPTPPDVIGLNKAEKMLLNLGALTDTALSQVKSRFKITELGRSMSLFPVTPRFAKMLVTGFQHGCLPYVIAIVSALSVGDPFIHEEALKATMNDDDSEDVRQAMRKAFFKSHQKFASLGNHSSDLFKVLAAVGAYEYAGGGEAFCKSNFLRSKAMGEIRKLRAQISYLIQSTFPNVDANFVPKLNPPNETQQKVLKQLIAAGFIEQVAVRKDLVEETENSGKKFQSCRNIPYKAVGIDQDVYIHPSSTIFNGEPPGFITYTEIIQTSQPYMKGITAIEASWLHKLGRNMCRFSKPIDVPLNAKLASSETKKEVIVEPFFGPGRGIKLPAVKMEQVKDSHGRWILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG44</accession>
    <name>I4YG44_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956981.1">
        <property type="nucleotide sequence ID" value="XM_006956919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG44"/>
    <dbReference type="GeneID" id="18474801"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62954"/>
    <dbReference type="HOGENOM" id="CLU_1922216_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG44"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="15328" checksum="E3733A7D6C4ECCD7" modified="2012-09-05" version="1" fragment="single">MLRKALGAVRTTPIHMLHFDTAVLTPTERLRMKAEAYMVRTLTRSGDHPARNIVTSILRKPRKKFTSPLNAMVRNTPMLEGLKEMETIVAHPFVPWVPATLSFSRAEDKDQAKAQHTELCRQYHKSWHFYTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG47</accession>
    <name>I4YG47_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_67823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956984.1">
        <property type="nucleotide sequence ID" value="XM_006956922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG47"/>
    <dbReference type="FunCoup" id="I4YG47">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG47"/>
    <dbReference type="GeneID" id="18475302"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67823"/>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_15_3_1"/>
    <dbReference type="InParanoid" id="I4YG47"/>
    <dbReference type="OMA" id="HEVKAFD"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="237"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="500"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="675" mass="75082" checksum="2CC2F6233396C130" modified="2012-09-05" version="1">MVVKYASSYPSSFLFTSPPTSTSTTIMNSAAPAPTLKKQKTAAKKRYLKNKKIRRKANQASAPKKKRRLDTAKTDDKNGDKESSDSSNSSSSSSSSSSSSESDSDDSSDSDDEKVTTKESKATTKEPEALKKSSSPTEPPGPVEAPQLPLLAFPEPQNLNTATQEELKKLGLPDVFANEIPVDANQTFPSAQSHTLGIGQRLKSRLTDVGFESLFAVQLAAIPLLIGDLKENIRHPLYPSESPRDICVSAPTGSGKTLGYTLPIVEIISRRLVTRLRALVVLPTRDLVSQVKETFEIFAKGTDLKVGTITGQQSFQQEQAKLVDQTDSVLAGGCSKVDILIATPGRLIDHINSTPNFTLQHLRFLVGILTYIFMELIYAKVIDEADRLLNQSFQSWIDRIQVALTTPIQTQPKRDTHDALGYPNSMLIDEKHDLIETFERPQRGVQKMLFSATLTTDPSKIRSLHLNEPKFVIVRNNKVEDYAIPTTLEERMIVSETAYKPLMLLHLLHQRGVRRALCFTKSVESATRLMHLLRLFKEEVGNGPTVASFSSDLSPQERQKMLTKFRDGEVDMLISTDVIARGIDIQGIENVINYDIPLDMPKYVHRVGRTARAGLVGKAWTLVEVQEAKYFKTYTKNAKHEVKKARPMTKEVEPLMEAYDISLIKLGKIYNHNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM4</accession>
    <name>I4YGM4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_50484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957149.1">
        <property type="nucleotide sequence ID" value="XM_006957087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM4"/>
    <dbReference type="STRING" id="671144.I4YGM4"/>
    <dbReference type="GeneID" id="18472529"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50484"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450710_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGM4"/>
    <dbReference type="OMA" id="ILLEVYM"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated" evidence="1">
        <location>
            <begin position="163"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="606" mass="68627" checksum="5564DDA7B1F7FA4A" modified="2012-09-05" version="1">METDGAREQALSLAKTLKQDGLDYQYIHLYAALQLFKQTSFNDASILFTKSQCDIRLILRWFPDLIAGLFDPDEFVRLPLGISTYISKIPHTIDQVIVANLEKNYSPYLSVEEDEPIKDLKTTLMNNARTMVLECLSREHRKRRRSRQSSHSDSDAYTDMILDTCLAIIFAEKTSMDRNALSIFVSQPNTVLLPIAEPTLVKQGRYTALARLYETHGDTTQALEIHKGLVEGSITDIDSVEPLKDTVRLLNKVEEPDVLLNYGLWLLAHNRSAGLQALSSHPKTPLDETKLLESLGNTDKIAEQEYLEILVLARNRDDKDIRRGLLERLIGNVLGAFKNESISKNMAKIDDEYKSQRRNKSYTQYLTNLLENDHTRTDVKESIKARIKLVLYLQISTDLDWSSIMRSLEPLINTTLMLEKGVILGKLEQHNAALNILARQLKDTYSAQHYCAFPGFILSANLARKCINDSHLSNSWLVALARTSMVAVSPSIRSHLLRVLLDVYMVDGDFFSAEIASLLGSQALHLDFIETLPKIPNDIPLASIKDFMLRQLRRSEHRKRELSILKGIAAAENLTRTEEAWLATREAGAVVEEAVDDTNNGYEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ8</accession>
    <name>I4YGZ8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_31387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956631.1">
        <property type="nucleotide sequence ID" value="XM_006956569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ8"/>
    <dbReference type="STRING" id="671144.I4YGZ8"/>
    <dbReference type="GeneID" id="18471293"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31387"/>
    <dbReference type="eggNOG" id="ENOG502QQ27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGZ8"/>
    <dbReference type="OMA" id="DGPSWMI"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="503" mass="55927" checksum="DBBBA82035C3B608" modified="2012-09-05" version="1">MASTTVDLLIAGAGPTGLGAAKRAQEQKADFLLVDKAVEAGGLASTATTKEGFLFDVGGHVIFSHYAYFDDVIHEALPNESDWFTHERVSYVKSRGQWVPYPYQNNISVIPIEDQSKAIDGLIDAAVVRAQTPHIKPKTFDEWIVRQMGEGIADIFMRPYNYKVWAVPTTHMQCNWLGERVAAPNPKLVIQNVLHKRTAGNWGPNATFKFPARDGTGGIWKAVAKTISPNKLRFGEQNGITSVDAKAKIVTLTSGETIKYNKFISTMPVDFTLDIAKNVEGIDGAKKAAKDGLVYSSTHVVGVGYRGVPPPDIKGMCWLYYPENDCPFYRCTVFSLYSPHNVPEQSRKTKTIQHSDASIQVTDSSEKEGPYWSLMFEISESHLKPVNHDTIIQDTIKGAVATGMSRPEDEIVSIYHERFDHGYPTPSLGRDEALKQILPVLDSHDILSRGRFGSWKYEVGNQDHSFMLGVEAADYALYGVPEMTLNYPDIINGKPNKERRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH77</accession>
    <name>I4YH77_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_35775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956705.1">
        <property type="nucleotide sequence ID" value="XM_006956643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH77"/>
    <dbReference type="FunCoup" id="I4YH77">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH77"/>
    <dbReference type="GeneID" id="18471930"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35775"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="InParanoid" id="I4YH77"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="209"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="688" mass="76896" checksum="C1D8389B9F114A18" modified="2012-09-05" version="1">MTLADSFKKLNLTQDNSALATKTLLFKSKKSQLPILVLADANAPASATEIGKKINVKDLRAADDSLWTTVLKAAKADASPFNLDSDCHIVLDQSLSQSSAPIQVKGLDGNLTSIDSKTLTEILQSNATKFDKLDFAAPAASPATSTPAQQPSSQQRKQAGKIAGAAEVAIGIRKEVDFPNWYTQVLLKGDMLDYYDVSGCYILKPWSFNIWQSIQKFFDAEIQKIGVENCYFPLFVSSRVLNREKDHIEGFAPEVAWVTKAGESDLEEPIAIRPTSETVMYPYYAKWIRSHRDLPLRLNQWNSVVRWEFKNPQPFLRTREFLWQEGHTAHIDHDSASEEVDHILDLYRRIYEELLAVPVIPGIKSENEKFAGGFYTKSVEGYIPTTGRGIQGGTSHCLGQNFSKMFDITVEDPEIARKANAEGRQLKEGEAKKFVWQNSWGLSTRTIGVMVMVHGDDQGLVLPPPVASVQVVVVPCGITAKTSAADAEAIEKGAKSIADRLQKVGVRAKADLREGYTPGWKFNDWEMRGVPIRIEYGPMDMKKEQALCVRRAANPNQDKEPLPLSELETGIPEMLKKIYDIMFNKAKDSFNDSLEVIMEDFDRIVKALNEKKVLAIPWCEEVECEKDIKERTENASDGEKDEKQPSQGAKSLCIPNDQERFGKIEEGKTLCVACKKPAKRFALFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC2</accession>
    <name>I4YHC2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_50317</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956745.1">
        <property type="nucleotide sequence ID" value="XM_006956683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC2"/>
    <dbReference type="STRING" id="671144.I4YHC2"/>
    <dbReference type="GeneID" id="18472520"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50317"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_6_1_1"/>
    <dbReference type="InParanoid" id="I4YHC2"/>
    <dbReference type="OMA" id="WYWTWKT"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="652" mass="73173" checksum="1DE14D5100F215DC" modified="2012-09-05" version="1">MPEAPNKSSLRNARNRRKGIIIASSVLAAIVVIVLVVALPVTLTRKNNNNSSQADEPVRNHEGNLIQTSGGDGSEVTLDDGNTFTYNNAFGGHWNSLPGNTDAQSQSYTPPLSERWDFNNDKILGVNLGGWLVLEPFIVPGLYEECENIDEPCVDELTLSNYYRSQGKLEEVLEEHYSTFITEKDFADIAAAGLNWIRLPIPFWMIETIDGEPFYEGGAFKYFENAVKWARKYGLRINLDLHTVPGSQNGFNHSGKLGEIHWMSSPMGVVNAQRTLNYIRAITELISDDDYKDVVQMLSVINEPFGPTIGKASVASFYFEAYKMIRDITGIGEGNGPWIAFHDAFLGGQTWNDFLRGADRVALDTHPYVAFNGQNQDPMDEQVWKPCAAWGESTNNTMADYGVTFAGEFSLAINDCGTVNGVNDGTRYEGTYIDKDGNRPEPGFGEGACDRFNDWQNWDDEFKSQLKGFGLSSMDSLQNYFFWTWKIGDSSRTHAPINPFWSYQLGLKEGYITESPHTEPSGTCEMYSKQGDDRQWVTNDAPATFPDWMLGKEGAGVLFGDQSEYQDFPPNSLNNINEQDMQNIPTYEKNGLRIQLHPLPFTYIDENGEQQSVEGSDGWFNDDDNSPFYSPKEDCDRYRSPYYDGDMIPGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHQ0</accession>
    <name>I4YHQ0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956170.1">
        <property type="nucleotide sequence ID" value="XM_006956108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHQ0"/>
    <dbReference type="GeneID" id="18475213"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67160"/>
    <dbReference type="HOGENOM" id="CLU_1027462_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHQ0"/>
    <dbReference type="OMA" id="ASNIHRN"/>
    <dbReference type="OrthoDB" id="3366178at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="267" mass="29863" checksum="643319B5B34F1165" modified="2012-09-05" version="1">MSNLFKQDEFAKKLEPPEEARQLGPPSGPSILKNSSEKQYKPSHERSSDYNQKESPRKLSVDSISFAPLPQRPTTMPRRNSITLGVAARSSFFNNAGGATNVHKNPDGSMVKTFTPEQWKQLEESQGRNVVDLGDVAVVAGKKFVNLLRGRRDSKDKTSDKEKEQFRNPRRDEKKLEDVGEVIQEEDAEIENSDDTLSPNTSQSHISQTTSDASDILTPPSDAMHMRTSSGGQLQPYKQDAYQEDEHLKAYALGFDPAKLGARRQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT6</accession>
    <name>I4YHT6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_62198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956205.1">
        <property type="nucleotide sequence ID" value="XM_006956143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT6"/>
    <dbReference type="STRING" id="671144.I4YHT6"/>
    <dbReference type="GeneID" id="18474719"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62198"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2160359_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHT6"/>
    <dbReference type="OMA" id="RPDNNVI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12551" checksum="FFA9B12C6C71D33D" modified="2012-09-05" version="1">MRLPFSKKDSNVIELPKPFSSHSREDSSSSSNASTSLSLTAQAPIKAKRKRANAYQLERLQSCYDANPFPSNDERQALATELNMSPNSVRIWYQNKRQALRNHEKAQSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU2</accession>
    <name>I4YHU2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956211.1">
        <property type="nucleotide sequence ID" value="XM_006956149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHU2"/>
    <dbReference type="GeneID" id="18473249"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59249"/>
    <dbReference type="HOGENOM" id="CLU_150838_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHU2"/>
    <dbReference type="OMA" id="DAGPYYP"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11058" checksum="2429139BE5937CF1" modified="2012-09-05" version="1">MSNKDYYQAGGPQYPPNSYQGGPQYGGPPQGGQQGYYPPPPQGYGQPQQGPYPPYGQQPGYQQPMYVQQGKPGKFSGGGGMGGAGGCCAVLTACLAGVAGCLCLDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU3</accession>
    <name>I4YHU3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_67191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956212.1">
        <property type="nucleotide sequence ID" value="XM_006956150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHU3"/>
    <dbReference type="GeneID" id="18475219"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67191"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="I4YHU3"/>
    <dbReference type="OMA" id="QPWWAAL"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="726" mass="80750" checksum="3B53C7A2DD70C825" modified="2012-09-05" version="1">MNYERVRDDESDSGNEFELSPLAGTEDSGTLKNTHARQHSEGTIIDAVTSIVPESDDPTLPTLTFRVVLIGSLFVSLGAAFSQLFYFKDNAPQWNPFIVLLSSYPLGKLMERALPERRLLGVNLNPGPFNIKEHCLISILATSGGTAAYASDVLAICTLYFKVDFPTWVAIALIMTSQFIGYSFAGLGYNILVKPLNMVYPANLPTISVLTTLHETNQLKRSKVDRKLRFFIFSFLAVILYQLLPSIFAPTLTSIAFLCYFSNNWIMRTLGSGYQGFGMLDISLDWSSLSSLGPLYTPPEALFNIFAGLVCMVWILGPLIYFTNFWDALSFNSPLSTGLFTKTHQTFDVQGVLTPDLHLDLNSWDEQKPLMLTPYFSIFYFFTFATFTATIFHVLLWYSGDIKAALLSSRKERLTDEETTKVVPKSYYIVTFLVTFIIAAIVCAQPIIQLPFWALALSLLMAAVCLVPLGIIRAVSGQSIGLNVLSELVIGYIMPGKPVANTVFKTFAYNSLAQSLDLIEDSKLGLMIHCPQKDVFICQYIGTAIGAIVNFIVLQDVIDTKRPYLDGTLVDPTGQYTGRSPRIMFSASVIWGLVGPARFFIGKYKVLLISGFILGIILPIITFLIHKRYPRFGLKHISFPLIFYGATLVPQMPANVIMSLLIVGYVSQVIIKKKFPKWYTNNYILSAALDAGTSISALLAYLILPYILVIVPTWFLNPSGDAEHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY0</accession>
    <name>I4YHY0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_31072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956247.1">
        <property type="nucleotide sequence ID" value="XM_006956185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY0"/>
    <dbReference type="FunCoup" id="I4YHY0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHY0"/>
    <dbReference type="GeneID" id="18471242"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31072"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHY0"/>
    <dbReference type="OMA" id="AGMSNTH"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="352"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="438" mass="48204" checksum="D3666159F8AD9C78" modified="2012-09-05" version="1">MDPYNKPQGPSPHYSLYQRELFANGPEGKLPSISSHPEKLQHDARKNLTDKGYWYSSSNAGLGWTHHANREAFYKHKIIPKTLQDTNTRDLTTEIFGHKIPAPIMFAPIGINKIYHPKGELAAATVAGELGLPYCLSTAASYSIEEVAEAHEKSASKKNESNSVNSYSGSKRELETSGPRFFQLYASQDSDVTESLLRRAWASGFDSVMITTDTPQLGLRMTDTDIANYAFYYGDLGNEMGLSDPVFMKKYGDDLKKDSSRWIDHSVWHGKPLTWEKVKDICKFWHELSGGRPFVLKGIQSVEDAETALSIGCDGIVVTNHAGRQVEGAVSSLEVLPDIAKAVGDKCTILFDSGIRTGSDIMKAIALGAHAVMIGRMWVWGLSAGEAGCRHVVRSLLADLDINMTVSGYRSLRDLKPTMLKYDPNGQLPAGLAEPSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHY1</accession>
    <name>I4YHY1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase A22B, signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_31073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956248.1">
        <property type="nucleotide sequence ID" value="XM_006956186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHY1"/>
    <dbReference type="FunCoup" id="I4YHY1">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHY1"/>
    <dbReference type="GeneID" id="18471243"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31073"/>
    <dbReference type="eggNOG" id="KOG2443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023799_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHY1"/>
    <dbReference type="OMA" id="FLYDIWW"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="392" mass="43394" checksum="8D9C5C8E6C448C72" modified="2012-09-05" version="1">MSEHNLLFYAYAALGVQAVGSVYTGSWGALKTPKATKKAIREAKGEEEDDEDEKDEEVAEKLNAGDAKMFPIIGSAVLGSLFLIVKYVSKEYLNLLLGCYFSLIGGFAGAKYLDSAFYNLIGTSLYNKLFPKWRLLLVKGKEEEARFPFTASSIGFLVVSLAASLSYLYFERPWYLNNFLGLSFAWTGIKLIELDSLKTGAILLSGLFFYDIFWVFFTPVMVSVAKGLDAPIKLLWPKDAGLSFIAELAQKAGYECECLSKYLSGDAPGFTLLGLGDIVLPGVFVALCLRLDLHLATVRHHQQQKQGFPPTASDKFCKPYFTTCLVAYFLGLLTTVVVMHNFKAAQPALLYLSPACIGSVAIASYIRGEFKEVWTWTAEEDKEDKAEDKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHZ5</accession>
    <name>I4YHZ5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59278</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956260.1">
        <property type="nucleotide sequence ID" value="XM_006956198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHZ5"/>
    <dbReference type="FunCoup" id="I4YHZ5">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHZ5"/>
    <dbReference type="GeneID" id="18473264"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59278"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHZ5"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="174"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="373" mass="41473" checksum="6AF526FF57A3E1FD" modified="2012-09-05" version="1">MTTQTPPKLWLRCETKEFEKRAALTPATTKALLDRGFDVTVERDPQRIFDDEEYERVGAKLAPHSSWPTAPKDTLIVGLKELPVEDTPLEHTHIQFAHCYKQQAGWADVLKRFADGNGSLYDLEFLTDDSGRRVAAFGFHAGFAGAAVGLLAHIAQQEGKELGHLEPYPNEDELIKDLKQKIQSAKSDKPVKALVIGALGRCGRGAVSLFQKAGLADENIIKWDMNETAKGGPFKEILDVDIFVNCIYLSSKIPNFIDRQFIEASGNDRRLSTVVDVSCDTTNPNNPIPIYNVNTTFDKPTVPVELKEGLAPMQVVSIDHLPTLLPRESSDAFSHDLLPSLFELTNRESARVWTEAKDLFVKFKSQALESLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI24</accession>
    <name>I4YI24_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_31108</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956287.1">
        <property type="nucleotide sequence ID" value="XM_006956225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI24"/>
    <dbReference type="FunCoup" id="I4YI24">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI24"/>
    <dbReference type="GeneID" id="18471251"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31108"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
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    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="56"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="506"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="450"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM23616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="642" mass="70520" checksum="C15D7AA852AF368F" modified="2012-09-05" version="1">MLRLRNIRGSALAGQRAFSTSKSLSRVVANEPLKAKQAENNAFASSNYPVIDHEYDALVVGAGGSGLRAAFGLAEAGFKTACITKLFPTRSHTVAAQGGINAALGNMTQDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPRTVVELEHFGVPFSRTADGKIYQRAFGGQSLEYGKGGQAYRCAAAADRTGHALLHTLYGQSLRHNTNFFIEYFALDLIMEDGECVGVMALNMEDGTLHRFRSHKTVLATGGYGRSYFSCTSAHTCTGDGNAMVSRAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTLEIREGRGVGPEKDHIYLQLSHLPPEVLHERLPGISETAAIFSGVDVTKEPIPVLPTVHYNMGGIPTKWTGEVLTIDDQGNDKVVPGLYAAGEAACVSVHGANRLGANSLLDIVVFGRACANHIRDTWEAGKPHKKISENAGLFSIENLDKVRNATGPKPTSDIRLDMQKVMQSDAAVFRTEESLQEGVEKMRKVYDSYAQLGITDRSMIWNTDLVESLELTNLLQCAMQTIVAAANRKESRGAHAREDYSERDDENWMKHTLTFQKDVESNHVDLTYRAVEGNTLDESECKAVPPFKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI84</accession>
    <name>I4YI84_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_56215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956342.1">
        <property type="nucleotide sequence ID" value="XM_006956280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI84"/>
    <dbReference type="FunCoup" id="I4YI84">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="18472785"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56215"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="InParanoid" id="I4YI84"/>
    <dbReference type="OMA" id="VMIKEVN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="58020" checksum="AD86C0EC30624520" modified="2012-09-05" version="1">MNTAPRVAIIGAGQGGLVSANEVKKRVPDAEIVVFEVRNNVGGVWNLGDTPKNYEIRFDDFGQAHAATSFSHYSEGVVDVKEEVPPSAIYGSLRTNLPTELMSFRNDEHLESTHRFPSHTEILKYLERFAKKYGLTKLIQLGTRVLRLKHADGVAKYKCGYLPQQKGRWEITLENVNTKQQAIEWYDFVINASGHYVQAHIPFIDNLWKFEGDLFHSRFYESAEQFRGKSCVVIGSRASGYDISREIAWLDRSPEHGQSPYNSVKENPGLPSTRIIQSRRSPPKYEWKEERPRWLDKIEQRGEVVGTHGRSVIYADGHVDHGIDVIIFGTGYTYTYPFMRPTDEPWKSNSVFPQSNQSRKNVLDDIPAHLRLPYNLPDSAQGSMTLVNLSKHNLFYLSDPSYAFVGLLRHVHPFALSEAQAHVIAFVLSLKERMIPSVLLQESYEADQFWTFPTEFEMTDEMLLAINEGKDYHIEKENVWSWYRTPEWVLKLAESASKDKRLLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA1</accession>
    <name>I4YIA1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956359.1">
        <property type="nucleotide sequence ID" value="XM_006956297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA1"/>
    <dbReference type="FunCoup" id="I4YIA1">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIA1"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="GeneID" id="18471260"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31178"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_2_1"/>
    <dbReference type="InParanoid" id="I4YIA1"/>
    <dbReference type="OMA" id="NGVCIRN"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="255"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="546"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="886" mass="99482" checksum="877271DF42DD9F28" modified="2012-09-05" version="1">MSEFRLPKTLKPINYNLKLKSDLVDSKYDGAVDISFSVYQSTNAISLHSHKNIEIEKLSLKTGTLKQEQAITPDYTFDEKLERINVALPFSLNPGDDVELSIAFKSSLDDSMMGYYRSSYKDNGKDVHYALTQHEPTAARKSFPCLDEPILKATYDISIIHRKDTVALSNMPPVHSAPANADTFAYSKHQGTINPEEWVITKFDKTPLISSYLVAWANGHFKHLETSYTSPISGKVRPLRIYATPDLIQQAKLGLEAKAQVLPLYEKIFDIEYPLPKLDTLVANDFDAGAMENWGLITGRTSVYLYDEKLSGLDAEKRVVGVQSHEVSHQWFGNVVTMADWHGLWLNEAFATLVGEIIVIDRIRPEWKVYSEFITQHLHRALDLDALKSSHPIQVPVKDPAMINQIFDAISYSKGGSVLRMLSNMVGEETFLKGVSIYLKKHLYGNAETVDLWNGIAEAAGIDVQAIMDPWTLKQGFPVLTVSESDKGIKVRQDRFLSTGKPTAEENETEWHVPLFIREGDKVDRSVALNKREAEFPLSDVSNSNWKLNAETAGVYRVLYSPERLTKLGVEASKSNSAFSLNDRIGLVNDAFVLAKAGNGPTSGALGFINQLKDEKEYLVWSAIGTSLANLSSVWAEESSSVREKIDALRRKLFSPLVEQLGFDNKEGDSPDVLQLRELAIASASAANDENVIKEIKRRFAPFLEKNDDSLIPNDLLRVIYAQSVKHGGAVEWEKCLEIVKNPNPPTPMHKIAAMLALGSTKDEKLIEKTFDFIEHGFKNQDLMYPFVALRNNPISRRKLWEYTKANLGKFEKRLEGNFSLGRLISFSFDGLAQPNDAKEVEEFFKDKDTSKYSSSLNQGLDAVKGNAQWLARDKADVEQWLEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YID2</accession>
    <name>I4YID2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_59362</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956389.1">
        <property type="nucleotide sequence ID" value="XM_006956327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YID2"/>
    <dbReference type="FunCoup" id="I4YID2">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YID2"/>
    <dbReference type="GeneID" id="18473313"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59362"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="I4YID2"/>
    <dbReference type="OMA" id="QINANYY"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000207">
        <property type="entry name" value="serine/threonine-protein kinase dst1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="388"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="595" mass="66252" checksum="D4FB07FDD37276F3" modified="2012-09-05" version="1">MNNKTTDPDKLFVLQERVGKGSFGEVYKGYDKRTHAQVAIKIIDLESAEDEIEDIQEEIAILSQMDSQFVTKYHGSYLKKTHLWIIMEFCAGGSCSELMKPGQIKEEFIAILLRELLRGLDYLHSEGKLHRDIKAANVLLNSQGDVKLADFGVSGQLSATMTKKNTFVGTPYWMSPEVIKQSGYDHKADIWSLGITAIELATGTPPYADLHPMKVLFLIPKNSPPVLDGNFSKLFKEFVSLCLQRDPKMRPTARELLKHKFIKNAKKTSSLTELIERAERWKMTGGYSRSAGKGDMLVNQETLGGSSDDLWDFGTIQGAQTHNLAGSMRNADMIRATPSISSHRTERTPQLHSRDYAKVPLQQDENELVQSTSRMTVDDRSFRSGSTLRAGLVRDRENRDKRDLRDPLQSVSNKPSPSKSSMKESSPSKSSMGYVDTLKGNKGAPRSSVASMYRELPPIPKDVKSPTQVFEAEISHSEKVSPAAATFGSDSTRSRPSNPQPPPTPVAEEELKRSDSQMTSQSTVEYDEEIIEQRTMLDAVIHPVLDSITSKVDTSDAHKAVNGLKRAFDDAETLIPGLTNYFISEVVESVERDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIL8</accession>
    <name>I4YIL8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GUF1 GTPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956473.1">
        <property type="nucleotide sequence ID" value="XM_006956411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIL8"/>
    <dbReference type="FunCoup" id="I4YIL8">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIL8"/>
    <dbReference type="GeneID" id="18473349"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59426"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_1_1"/>
    <dbReference type="InParanoid" id="I4YIL8"/>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="645" mass="72426" checksum="334679DB7B7890CA" modified="2012-09-05" version="1">MSFTFKFLLKSASPRLPFLRSQLKRNFSTTHSKWINIEDFPTERIRNFSVVAHIDHGKSTLSDRLLELTGTIKPGQNQQVLDKLEVERERGITVKANSSSMVYNHNGHDYLLNLIDTPGHVDFSYEVSRSLGACDGALLLVDATQGIQAQTLSVFDLASQRNLKIIPVINKIDLPAAEPENVIEQVALQFDLDMDLALPISAKSGLNVESVLHAIVEQIPPPPASNIPLRQQPLKALLFDSYFDKFRGAVSLIKLESGMVQKGDVIVSHHSKSKYTVTEVGILNPDERTTTHLQHGQVGYLVCGMKESSEAHIGDTIYKQSMLVEALPGFQPVKPMVFAGVFPVDNKDFMRLEENVKRLTLNDPSVTVNRESSNALGQGCRVGFLGQLHLDVFRQRLEDEHDSEVIITAPTVPYKVIQNGKERIIRVPSEFPEPSELSNRKSSLFEPYVNAEIIVPDEYLGNVIELLSEHRGDQIAFNYLENSNPPRVHLKYHLPLAEIVTDFYSKLKSATSGYASFEYQQADYVASDLVKLNMVIHHRPVDALAMIVHRSKSMEVGKHWVKKLKDVIPKQQFEVAIQAAIGQKPIARETIKAMRMNVTEGLYGGHFDRKLKKLNQQKRGKAKLKMKAVGNIHLPQSAFYDLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP4</accession>
    <name>I4YIP4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955683.1">
        <property type="nucleotide sequence ID" value="XM_006955621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP4"/>
    <dbReference type="STRING" id="671144.I4YIP4"/>
    <dbReference type="GeneID" id="18474669"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61673"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="I4YIP4"/>
    <dbReference type="OMA" id="IAPKACI"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="301" mass="32664" checksum="326A71CE5080DED0" modified="2012-09-05" version="1">MTIQLPRGNYTTITIIYNNDQKQTVNNQATAAHAVTIAHAGTSGIVVGSNGEHQSLSIVETNIVTKSIRDALDLYKLQDIPVITNVASQSTYESIERAHRAKLSGANFILLPSLAPNLSRDDNMSFFEDVAEESPIPVIIYSHPQSSAGFHLTSDEVIRLAQHPNIVGLKATDNDVGKMTRLTHLSKTNNFHVFCGSSDYLIAALSIGVHGSITAAANFAPDLLFNVWDSYNKGKAGEALDLQRKLSVVEARCKVGGVAGIKYATSLIYNTNPKPRKPLRELSEDIKEIVRSGIWLLKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT6</accession>
    <name>I4YIT6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955722.1">
        <property type="nucleotide sequence ID" value="XM_006955660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT6"/>
    <dbReference type="GeneID" id="18473108"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58989"/>
    <dbReference type="HOGENOM" id="CLU_1046640_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIT6"/>
    <dbReference type="OMA" id="YKNTHRM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="239" mass="27240" checksum="DB8B6C44BDE25A64" modified="2012-09-05" version="1">MLHLPGRIQEAKRADSPMILDDKPEAGTSKSIGIPPLEQRLQYHRTKGNLLRQPPSNKVNIDKCTNVKQLEDIISRFDRLSAGNLVPTEKIADNRGKAQKRLEELRENGINEDMSKLSINKGKYKETPVDSRVFISVEDSLNLQREEHKRQETQRMVDEMMSSSKVAQQEAAHQFNFSDSDDSDDEDEDDDNWLLPSYAKRKTDQAEELQQLEQLDIQDDELTNAHIDAAGALLERGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ34</accession>
    <name>I4YJ34_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4038 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_66852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955811.1">
        <property type="nucleotide sequence ID" value="XM_006955749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ34"/>
    <dbReference type="STRING" id="671144.I4YJ34"/>
    <dbReference type="GeneID" id="18475162"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66852"/>
    <dbReference type="eggNOG" id="ENOG502RX0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023504_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJ34"/>
    <dbReference type="OMA" id="YLGDTAW"/>
    <dbReference type="OrthoDB" id="2581507at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025277">
        <property type="entry name" value="Apiosidase-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024749">
        <property type="entry name" value="Collagen-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37836:SF2">
        <property type="entry name" value="DUF4038 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37836">
        <property type="entry name" value="LMO1036 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13204">
        <property type="entry name" value="Apiosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12904">
        <property type="entry name" value="Collagen_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697750" description="DUF4038 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Apiosidase-like catalytic" evidence="3">
        <location>
            <begin position="33"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Putative collagen-binding" evidence="2">
        <location>
            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59264" checksum="2341FCEBCD4F0524" modified="2012-09-05" version="1">MLPKLLLSLGCLALTLAKPVESGHSWDSLSITTKGRYLSKRVDGSPFFWQADTAWEIFHRLNKTDVDLYLSDRAEKGFNIIQAVAVAELNGTTHSNYYNQLPLVNQDPTQPIEEYFEYVDYVIDRATDYGILVALVPTWGRYVNCGWRGEPKLFNVENAKEFGRFISNRYPGLPKIIGGDSNGDWACDLPDIQEEYEDNYESNPDQDPYSMLPEIEDTRDVWSSMVDGMKEGEEDLFVIYHPTNTYLNVTGLPLAYGSNYLNGTHEVSMNAVQSGHSVPGINPPNEAIVGWNSVRNYEFIEDMRRAFDGSVIDLENHYEGARLAFEADQRYWTASEVRHGLYNGFFAGSAGITYGAHSIWQFYDPIYNLDQARLYIEPQNNLDPNDSWRNGLHFEAAGQVVYLQNLFKDLKPEVFFSMEPDRSFIQSIDGGEDVLAYAENRRVGALKSDKLYWVYTGFGDAFKVDLSNETGIVSTKWYDTRTGQSQDENSYELDDNNKVMAFYPPTSGTIDNDWVLAIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA9</accession>
    <name>I4YJA9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_26768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955881.1">
        <property type="nucleotide sequence ID" value="XM_006955819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA9"/>
    <dbReference type="STRING" id="671144.I4YJA9"/>
    <dbReference type="GeneID" id="18470951"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26768"/>
    <dbReference type="eggNOG" id="KOG4317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863827_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJA9"/>
    <dbReference type="OMA" id="AVITDIW"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="322" mass="37528" checksum="169BE2FB1E3FEF8F" modified="2012-09-05" version="1">MILIRYKDLLINPLNCFKSEVHSDCNQNFTNNQLKDELSINNQSNLLEKKKALDLLKKFNEENDIDEFNEIDDDTMQRLASLDLESSDPSTILNALSKEERDQFENLTNPSNSATLTRLLHLYQQSFHPWYIDDDNNSENESDDLLDKPEAKSFDLHPGGEILSSNLVAIMFSYAFILRRFGLRYLSDLENTSRDIRDAKGELSRLLPFLKEKRSNFAYVNPREAVHSIWSRIPPEIRTKEFLDLLLDDTKCLLKPLKPVHEESDRVISTQCLFDILQVFGEAKTPFTTKLTFYLTRCHNMTAYLKKLNFNIDIDRHENPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJK2</accession>
    <name>I4YJK2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_53205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955969.1">
        <property type="nucleotide sequence ID" value="XM_006955907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJK2"/>
    <dbReference type="STRING" id="671144.I4YJK2"/>
    <dbReference type="GeneID" id="18472606"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53205"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="InParanoid" id="I4YJK2"/>
    <dbReference type="OMA" id="IIIARLY"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="53870" checksum="77A249E909D30D24" modified="2012-09-05" version="1">MVEYKRAIVDHFKVSKNPDHTWLGYLQFFSAWFCWLMDAYDYFSVSLSVTGLGEYYGQDTTSVTTSMTLTLLLRSAGALISGLISDKFGRRNVLVATMTIIGALSLATAYAKTFPQFLAVRALYGIAMGAIFGPASSIGLESLPAEARGLFSGIFQQGYAVGYLIAAVVNLGFVPDMPEHIGYRGLFYLGAALSWAAGIIRLFIPESDTYKAAKERKKEQIEAGDYQQVSAKVYAKEIGKMVKNYWIQIVYCFWIMTLFNFFSHSSQDLYPKMMETAKCQTEHDATLATIISNVGAIVGGTIAGAVSQKIGRRFTMALFALLAGAFIPLWILPNDWSSLAAGAFFVQFGVQGAWGVIPVFLQEASPPAYRALFSGLTYQLGNMVSSASAQIEARGGEDRQIVDCHGEVVDDYATVSGIFVGIIAALIMITALAGKENLGKAIEKSKTAGEAGAGEQENDEVGPMATFDDREKGLKRVGTDSLYSTDKASITHKEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJN1</accession>
    <name>I4YJN1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1212-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_30895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955994.1">
        <property type="nucleotide sequence ID" value="XM_006955932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJN1"/>
    <dbReference type="GeneID" id="18471205"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30895"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_0_2_1"/>
    <dbReference type="InParanoid" id="I4YJN1"/>
    <dbReference type="OMA" id="PWWQRTP"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="473"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="769"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="903" mass="99014" checksum="F07208A7E3108EAD" modified="2012-09-05" version="1">MSDSQENSRPKSARRVQFTSSTDNQDPSYSLDPSLDDSHLDIDAFKKLQIQLIRNSLSKTESRPESVSSVDTTISQDAQLLPDDSATPASSTLPSRAPTPPQEYAVPIPFGEIDGLPQAPSSKKGTFDYYTKKARKLIGIKKGIDNKKEDKPVNKEDPESGHSSDDPFSLNYKPSKSRGVLSTLLGLQEYRDQHKAKKKAKKANRQRRLSTDTSSSEGTVLSGDHISEKSPPAKVATPPVTPTLPRSKSEPDLADIGNGDLNKDMNAFRQYKPSAFRIPDQLRLRPEKYRPKTARSSAGVFGALISSGQNLSGFVSPHSTAIAPNLKHQGYRLQRYSLDPTLDIKEFTKDNQQSEKGSSFDLERSGTSSTDLDSFNAQSQSSKKITPKTLLKDQFSHVTGFGKSKSPVASPDEKFSSNASLDYFSLPLKEKDKEKDARSDKELKERKKNLAKRKKEELYITMHVATVLHRQEFLLKLSRALMMFGAPSHRLEAQIQACARVLDIPLQVVYLPGLMLFSFGDVESHTSETKFLKQSSTLDLRKLLATHQLYWRVTHDEMSVSDASKDLDFLMTQKDSFSVLSNIVIAGFCSAFITPFAFNGSLIDACLAAPLGMFLVAVQQIAVKNDLFTNIFEISMAAMNSFLAASLAQTHKVCYSAVASGSVVLILPGYIILCGALEMSARNIIAGSVRMFYAIIFSSFLAVGMSIGFQFFKLVTNQWNNEDTAADDFSCNAAHPDGAPFYQQQIDPYWYILCVPVYAIFISLRNKASIKSRELPLMVIIAICGYTVNYFVKQRISRVDLSSAVGSFTVGLIGNLWGKFTTSRPAFTMTASGIMLLLPTGLSDGGILSVARTNSTDNSSLGLGTSGSLIQAAIGLTVGLFAAAVVAHPFGGTKRRRAAIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJR4</accession>
    <name>I4YJR4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_59143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956025.1">
        <property type="nucleotide sequence ID" value="XM_006955963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJR4"/>
    <dbReference type="STRING" id="671144.I4YJR4"/>
    <dbReference type="GeneID" id="18473195"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59143"/>
    <dbReference type="eggNOG" id="KOG3112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062640_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJR4"/>
    <dbReference type="OMA" id="PISWKGV"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="229" mass="25611" checksum="976965C951D05133" modified="2012-09-05" version="1">MTFIKYEINFNEEELKGKTLVLPTISMANVPQLATELLLNNHSNELVGRFNNEGFIQVAGASTDGLVTPLELHRLKEYNDIYVVDQRSPILKSYKYTFVEELKKWADGLNLSVIILSSADSASRNDNDIVSSQLKQISSKDSRYADKISAFESLDLDTLNGTGLLKSYYGSLKNVAGLCLFTTEGDNRPDAHLLVKALSNVLGFKPIELKDPLHWEGLFGRLYDDKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJR5</accession>
    <name>I4YJR5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_14214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955664.1">
        <property type="nucleotide sequence ID" value="XM_006955602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJR5"/>
    <dbReference type="FunCoup" id="I4YJR5">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJR5"/>
    <dbReference type="GeneID" id="18470628"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14214"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003736_2_0_1"/>
    <dbReference type="InParanoid" id="I4YJR5"/>
    <dbReference type="OMA" id="MRMMSVC"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="394"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="724" mass="83268" checksum="4E7D18113D713A60" modified="2012-09-05" version="1">MLENNASNIPQLPNPPILPAAPISTGLSKSQILSKWRDEQGRRIFTRENTSDVIKGLNNTPSIDILRDTVNILQGIDGAYFRFEGAANQSEFKLIPTDQRSKRVPKPTLELVIRLAELGWLYKQVAAFVRDCSTSTSLGLITQALSRHVQNRLYDFYRLIALLEAQLAHTPETMDEQNDSMDSLTLGRIAVWTEEWRLKMRMMSTLVQGAADVHGGALVSLIHGYTENGDPFIRGFVSELLEEVSQPFFNTLHTWITSGELYDPFKEFFVTINNDLGMDLNSFGWMIGAPNTTEHKANIDAGQLWAKKYSVRDEMRPRFVGQAFAKKIFSIGKSLNFIRHSCLDEEFFATNQISDIANKVLTYSDIPSLEQSIDIAFSIASQRLLENMFSKYKLMDHLQALKRYLMLGSGDFVDILMESIGPSLARPANTLYRHNLTATLEAAIRGSNAQYDDPEILRRLDARMLEYTHGEIGWDVFTLEYRVDQPLDVILTPEVMSKYRRIFNYLWRLKRVESDLVKGWRRCVMGKRSYLKVPSLDNDWHQARIAMSEMIHFVKELEAYCHLEVIECSWEIIEQFASKREGDLDALISAHREYLERIVNKIMLVGGRSSRRDEELLHKMKQLLSVILSFRRAVEDLYTFTLHMSSSLDHTPLERPDIYRHKRLVADEEEEGIAGIRYRVQTSADEFHELASYVVNALQSHPDLDVRFLAVRLGFNQFYRKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJS0</accession>
    <name>I4YJS0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">WALSEDRAFT_42426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956030.1">
        <property type="nucleotide sequence ID" value="XM_006955968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJS0"/>
    <dbReference type="FunCoup" id="I4YJS0">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJS0"/>
    <dbReference type="GeneID" id="18472251"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42426"/>
    <dbReference type="eggNOG" id="KOG3293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_2_2_1"/>
    <dbReference type="InParanoid" id="I4YJS0"/>
    <dbReference type="OMA" id="RGAFGNR"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="126" mass="14366" checksum="A9C694ABD9660CFF" modified="2012-09-05" version="1">MLPLTLLNGAQNKPLLVELKSGETFNGHLIACDNYMNLTLKQVFQTNADGERFWKLPECYLRGNTIKYIRVADELLDQIKTTQDRDREQYKNQRTGSERQERGRGRGRGGRGRGGRGRGRGGQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJY1</accession>
    <name>I4YJY1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein ryh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ryh1</name>
        <name evidence="8" type="ORF">WALSEDRAFT_42518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956088.1">
        <property type="nucleotide sequence ID" value="XM_006956026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJY1"/>
    <dbReference type="FunCoup" id="I4YJY1">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJY1"/>
    <dbReference type="GeneID" id="18472255"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42518"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="I4YJY1"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="23536" checksum="41AEBA113A4F1AC9" modified="2012-09-05" version="1">MSSSALDQPATSSQPLKKFKLVFLGEQSVGKTSLITRFMYDTFDKTYQATIGIDFLSKTMYLDDRTIRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVSNKNSYDNTSKWIEEVKQERGDDVIIVLVGNKVDLSEKEVNNDQVKEYCDNNGILFIETSAKSGFNVKQLFKRIALALPASEQDNSQNDNVKIQVDNQQADQQSSCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y513</accession>
    <name>I4Y513_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_58952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668265">
        <property type="protein sequence ID" value="EIM19055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960898.1">
        <property type="nucleotide sequence ID" value="XM_006960836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y513"/>
    <dbReference type="GeneID" id="18473088"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58952"/>
    <dbReference type="HOGENOM" id="CLU_1595840_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y513"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="167" mass="18400" checksum="0A870765EC54E5FE" modified="2012-09-05" version="1">MGKSRKVLNAFSFIHTSSFHHQCIINHVKHVSSESPFIVYICGLHLTVFNSILPTRISDAQECESVDLCTLDSDTGAGYGTSSAWAQLIKFYTREKLITCADSQEIFHLGDVSHSSPVVNEKISGLLACCSDQTSMQVDGLQTRSRTGLLSYVQRSFEGLVNYGFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y520</accession>
    <name>I4Y520_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_53048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960895.1">
        <property type="nucleotide sequence ID" value="XM_006960833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y520"/>
    <dbReference type="GeneID" id="18472602"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53048"/>
    <dbReference type="eggNOG" id="ENOG502TDMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151499_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y520"/>
    <dbReference type="OMA" id="FWYNLNL"/>
    <dbReference type="OrthoDB" id="5538176at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="102" mass="11228" checksum="332134BA81D2E76A" modified="2012-09-05" version="1">MALSRRCIIQISALSTLDGRIEAYHGFNGEPEKRLPHPRKAAGAQLTQSRHGEVVTINNNTGLFWVLNNWRASLVPAAAVIPAPIAYIKVVAIKKPVVEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H6</accession>
    <name>I4Y5H6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960715.1">
        <property type="nucleotide sequence ID" value="XM_006960653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H6"/>
    <dbReference type="STRING" id="671144.I4Y5H6"/>
    <dbReference type="GeneID" id="18474609"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61569"/>
    <dbReference type="eggNOG" id="ENOG502S7VV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034949_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5H6"/>
    <dbReference type="OMA" id="GAHMWVE"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51040" checksum="B07EDA971424B3CC" modified="2012-09-05" version="1">MRNSRVLRNTNLNIKHQHFIKPTLETASVFKNILKWSSFFGFLGLVGSLAAFEGLNQYVEFYKLERATLAYEPPSNDIEEWSFENDDWSGGQSGGTEPSLPWKAAHLIRSAWIALEWGVGTASNAASLNPSLEISQSYLLSAINHIESNDNVKNKDIALSALYLRLADIRQRMGTRVSLNNALDGYEKVHSFLVSKGGPKTALMKVERSAGDVCKSLGLDKESERWYFKCLNHFSSSKKNTSFGGYMPSWLTRRQEVDTQIDIRLLSPSQFRAYIDTLLSLSRLYSTTNRLTEAMTVQKRLIDVLTNSIDTKQGLQNDWTKHSLALSQVHLAEVTYALNKNKLDESLGWLQNAEQLSSNVHRSIENVNTSDAFSKNQAHKLTNASQRTASECAYLMGILHQSHDDKERALGCFERAIKTTLQVDTLTKDDLDSLSKDPINRKYIDAYKNVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5I0</accession>
    <name>I4Y5I0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960719.1">
        <property type="nucleotide sequence ID" value="XM_006960657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5I0"/>
    <dbReference type="STRING" id="671144.I4Y5I0"/>
    <dbReference type="GeneID" id="18473076"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58849"/>
    <dbReference type="eggNOG" id="ENOG502S3VX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051226_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5I0"/>
    <dbReference type="OMA" id="IQMEVTD"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35176" checksum="EC34896F1D3EB356" modified="2012-09-05" version="1">MSDDEDYRKAALRALEATLESQFAAPSDNHLSDEALSDDDGQDDNAEPNEEEFDSDDDIIGESTAAEVDELFSLGKNKGKAKEINDDTNKKLQNQPEVVVFGENTSSSAPRDKDSKRAQKAFMSSKIDKVQKGPSQNTNAKQRKPISELSEIDKTNLENDKELEHLLHSQLFTMPENTKNMKAGDKMRMYEGRLLEIAGKAKLGSGAANLKKKEHKNASGLIRTGLERREKEVKQNELQRAKDLGIYDKSLKHVYEDAESGKKSVKRSFGNVNADRDNKRQKGLGMGVGKFKNGMLTISKSEIDSVNSQPKRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y615</accession>
    <name>I4Y615_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_22473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960557.1">
        <property type="nucleotide sequence ID" value="XM_006960495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y615"/>
    <dbReference type="FunCoup" id="I4Y615">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y615"/>
    <dbReference type="GeneID" id="18470923"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22473"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140539_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y615"/>
    <dbReference type="OMA" id="HQEQESH"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="121" mass="14052" checksum="8A709DD459585C6E" modified="2012-09-05" version="1" fragment="single">KHVLNAQAAIRSPCCRKWFDCPECHEEKEDHPLAKSLELAFMCKKCKRAFRKDMTVFEESDEFCPHCDNHFVIDAKTPEAALMVEGEDARVDNRMIKDERSKIDPERTINARNNELSDRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y638</accession>
    <name>I4Y638_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_66411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960580.1">
        <property type="nucleotide sequence ID" value="XM_006960518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y638"/>
    <dbReference type="FunCoup" id="I4Y638">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y638"/>
    <dbReference type="GeneID" id="18475112"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66411"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="InParanoid" id="I4Y638"/>
    <dbReference type="OMA" id="YYYFGKK"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="228"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="500"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="729" mass="80105" checksum="D92FC8B44C340FD1" modified="2012-09-05" version="1">MIIQNIGNAANNRQNNRIYINNTKLREIRLQISQLVVIEANSSFIVGSAWPSNTEDELIGVHTPLFNQLGVNQPTNVEILTDLSKLNLIPISSISIDTDLQLDDRQSRLLQALIKDFLVELRFLKPEFKFSLHFKSKLNHFKVLDLDTGLSTLALNDNRRAYEVTPSTTIRLNSSTQNESLTSQATLIEPSTERPLIGGLSKQINEISDLIGLPLNYPDLFTRFAVKPPKGLLLHGPPGTGKTLLARSAATILSLPILLVNGPELSSAYHGETEDNLRKVFTHARSLTQNKGVIVVIDEIDTLCPSRDGDGSTGEVEKRVVATLLTELDGMNNGKDTNSPSVFLIGTTNRPNALDSALRRPGRLDREIEVGIPDASQRYEILTKQINSMPRNVTAEDIHSVATKTHGFVGADLSSLVRAASTRAIKRSIEEKTDAYLQVQDLVDALPHIRPSALRSVQLTLPETRFSDIAGQEHVKKSLEQSVIWPQRHADTFVRLGLTPPRGVLLYGPPGCSKTLAAKALAGESGINFLAVKGPELLDKFVGGSERAIRDIFAKARAAAPSIIFFDEIDSIASARDDNSSTTSGMVASMLNEMDGIEELNGVTVLAATNKPQVIDPALMRPGRLDRIIYVGPPEQEARKQLFALRLAKMTVEEGIDLDELSKMTQGCSGAEIVSICQDAAMRAMQESLNAEHVKKQHFIDACWAVRRRITTEMLTSFESWRDQQAAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6A5</accession>
    <name>I4Y6A5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960422.1">
        <property type="nucleotide sequence ID" value="XM_006960360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6A5"/>
    <dbReference type="GeneID" id="18474522"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61415"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_1_1"/>
    <dbReference type="InParanoid" id="I4Y6A5"/>
    <dbReference type="OMA" id="NTFHEVG"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="502" mass="54404" checksum="1C0EF6E8A3A229A2" modified="2012-09-05" version="1">MVASELSDSAFVNHPGNFRRAILLAIFSTVQFLDVFGVYVTLISLPAIGEDLNIDSATQNWIVNGYLVAFASFLLFAGLLSDRFSPRIIFTIGLAVLGILSLVAPFCDNAIGLIVLKSFSGIGASVTIPSAIKLITQMYRDTESQAKALGIFCATGGLANVIGTIVGGCLTQADWRWCFWILTIIALPLSPISFFLTPKEKVLYHKGARIDVISVIQLVIAVVLLIFALTSGNNVGWGTAQVIAPLVISIITFIIFAWWQTRVDQRSALLPKRLWTYPGFTVLFGICFMITPWWTTTLESLTKIYIDVWEFEPLSAVVHFIPFGISSVLCSISIAYLLRYINTKAALLFGFIASTTGAIVLGFGDDIDKFWRLQVPGMVIGSGGSAILYCASNVAMIQSAPNSESGLVGGVFVTAQQLGSAIGISLFTVVQLQVDKRDTSGNDFIGTSAGDWFLAGVHFCGLLLILFLLPWKVGAGENATVDYNEKEINEDEEGKKDTKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D2</accession>
    <name>I4Y6D2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960448.1">
        <property type="nucleotide sequence ID" value="XM_006960386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D2"/>
    <dbReference type="STRING" id="671144.I4Y6D2"/>
    <dbReference type="GeneID" id="18474529"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61429"/>
    <dbReference type="eggNOG" id="ENOG502S9K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1723743_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D2"/>
    <dbReference type="OMA" id="AGACPPY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="152" mass="16149" checksum="1FD510EA1C0508BD" modified="2012-09-05" version="1">MPQPGSNSPMPPPQQTRQSKSSKFKSMLGLGSSGSSKPSYGQNYAGYGQPQQYGSSYGQQQPYMQPQQGYMQPQQSYMQPQQPMYVQQPVGGGRRMGGGMGSMLPMAGGLGAGMLGGAFLAHEFDESQQDAYQDGYQDGADGDFGGGDMGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6G3</accession>
    <name>I4Y6G3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIP120-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_30260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960353.1">
        <property type="nucleotide sequence ID" value="XM_006960291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6G3"/>
    <dbReference type="FunCoup" id="I4Y6G3">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6G3"/>
    <dbReference type="GeneID" id="18471136"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30260"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6G3"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135951" checksum="B0B4F1D0C4DF6C35" modified="2012-09-05" version="1">MAQQQKVISLINKLKDVDSDYRFMAMNDLNLLIKNYQIINDDLEIELIDSLLKSLDDNNFEVKQLTSNSIELLLNKLKLKSLNYLIDNLFELLKNNKKDDLNDIYLVTIKLIIKNLDNIQFINLDKLIKNVLVLDLSIESLDILLELIHNFILNRDQSIEVLDSQFNILSSSARYSLKKKSIYIISLLIDDYYQDKLNEFINNNINSQFIITNLLITNTLNILNNTNHLDIIIHHLDNSDDEIKESALLTLEAFIKHLNPQQHLESLIALSSKFISYNPNYFEIDDDDDDIDEDDDEDQEDEPLSDNDDLSWKVRKASAKLISTITLNNPHLLHQLCSSIFLNLLNITSNEREESVKLEMFNAINSFFLINASLNERCSLKRKHNEMDLDLNSDLQNETYQKPLIKTITKHLNDKSLVIRLNAYKLLNTLVNTFQDSLQSPHIDDITPFIEQGLKDIQSTISAGLPIEILTFLNSLFRTHTYRSIHQAIPSLTDALINTTKLTKYHKLCSLALTSLENLVTLLRPLREDGKVSPYPLQQERIDSYLELINNAVNESIQDSELSNNVKEDAINVVAVLLSHAGDIITKNNDSRSLSLLSSRLSNNLTRLAAIKAIKVAANSTTCDGQLFQTWFLEFLKQITPLIKQNDRVVKITTFECLEALLDRVVNEIDLDLANELITSTLPLITINDLHTLPYALNIASQLVQGRDEIRNSIVKVLHQSYSLVLSPLLVLGGQGLDSLEKFYQLTVTYNPSAGPEIVSNLLDQVKDVSVSDVGGEGEHILANVSKLIGGVIVTSKGDIENFLNVLKSPNQVSHVYLSLLVVGEVGKDIDLSVKYPDLFTIVGGYFNNDQDNIRRASSFSLGNISAGSTKIFLPELLKLMKNSDYLILSSIKQVISQSVEQIDQDQIDKLFNSLISVGDDENVRNVSAECLGKLCLSMPSTYLPKVKDLLDFEETKLISIVAIRYTLTESTNENYLVDIFNKFDQLLVDSNLEVKKMTLSTINSAARHKPTLIKESNIPLLLQQTDSKPELIREITLGPFKEKIDDGLPIRKTAYECLYTISNHCVSLISKDDLIGQVLKGLNDVDEIKILTYLILNRLVMIDRDVVMNSIEEIIQKLEKVLLFKPKDSATKMEHERNSELQTSVLRTLATLNSVISMERNEHLNKVIKQTVEPNAQFRNTFLSCSNLTASQFSDAMQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H8</accession>
    <name>I4Y6H8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960368.1">
        <property type="nucleotide sequence ID" value="XM_006960306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H8"/>
    <dbReference type="FunCoup" id="I4Y6H8">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6H8"/>
    <dbReference type="GeneID" id="18474506"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61393"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_2_1"/>
    <dbReference type="InParanoid" id="I4Y6H8"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="450"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="598" mass="66996" checksum="C4297052B442BFD9" modified="2012-09-05" version="1">MPILEQPNKKRRVLTHESTYLNNLPLSDRYTKSFMHRDNLLTTSTTKTNYLITTSAEGNIKFWHKEPKGIEFRKQFRAHLQSIITTAVSNDGSLVATFSDDSSIKVFDVVSFDMINMFSLDFTPLTCAWIHSPSQGDSVLAITDKNSSAIHLFDGRGDGKPFHTLTNIHNKPVSIIRYSDIFNTVISADQGGMIEYWSPNEPYETPKDVPGLWEFKSSTDLYEFRKAKAPPTSISLSPDSTHFVAFSISDRKIRIFNFLTGKLTRKYDESLEAASEMQQAGTAIYKLDDMEFGRRLALESEIQENEQAVANMNVVFDESGNFIIYPTLLGIKVVNIVTNKVVRVLGKDDSIRFLNVSLYQGSPSKKGFVTAQMAASDNPLLAESQARDPILFCTAYNRPRFYLFSNADPEGSGDRDVFNEKPTQEEQAMSVAPAQKQIKQRPAASKAVLHTTLGDITLQLFPDKAPRAVENFTGHANSGYYEGVIFHRVIRRFMLQTGDPLGDGTGGDSIFGHDFEDEFHPDLKHDKPYTLSMANAGPGTNASQFFITTVPTPWLDNKHTIFGRATAGMDVIHKIEELRVDRKDKPEEPPQISSISVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J1</accession>
    <name>I4Y6J1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960381.1">
        <property type="nucleotide sequence ID" value="XM_006960319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J1"/>
    <dbReference type="STRING" id="671144.I4Y6J1"/>
    <dbReference type="GeneID" id="18471782"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33953"/>
    <dbReference type="eggNOG" id="KOG1897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302513_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6J1"/>
    <dbReference type="OMA" id="IVDFCLF"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="442"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="695"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="986" mass="108939" checksum="7895A951707244AF" modified="2012-09-05" version="1">MTDGISEIGRVDVNGRVIGIDKIIFQTHESLLLTLDHPQAQLVILSLSYENGVIKHIVECTKMLVETTGEPSYEYCNSIVDKSTQIGVSHLWQGQLHAFKLSYDDRRKTHIIDGRNSQIDHSVVLSMAFLATDKDEKPTLCRLVQSADVDNPLLVFEHLICKEDYVDISQTVLRIETQCPSAQKIVAVEGKKRAVLVIGAFGCEYYEIPKKDLKGVRRKSSTTVTSPQVVDMEHLSVKSPMAAVRGYTAVNDSCTAWLIGDEKGDIYYISISNFLEITLVGNSSVASTLQHLGSGFLFLGSQNEDSKLLVVQTNPVRIVELENYTNLAPVSDMALTHPDGIQGQLVVCSGSNKTGKLRVVTTGIGLCDIYQVGLGDSISNVFILGSHLLVSYLSTTKIYDIPNGLYGTFDESVAYQDVRRDMPTLSVVSSGGRHGIYQSNLLTIFDDSGNLVERKETEIDFVSVSEDLESVLVVGVEGLVLHQKGQRRNLHKPEHAATYAILDDNHIVYTTWTDYSVNIVDSRSNELIYSCKSRDDTPILSLLVENKVVLAGSADGSLYAFRFDEHLKSVDIQTVAIGSTPVCLTRSNDGLIFALCDVPSIVTLDNTRLRYSSININYINGLTSYKTNDMVNYVFVQNDQLKFSRILSTENRVHIHSIEMGADVPRQVAYKEDRYAVGCVRNAYRSDRTLYESSSCVKLLDNNYEQLAQMEMEKDEIVSVVESLSIANMEVFVVGTYYNNETEGTEEATKGRFIILLVKDDKFIIASSFLVPGCVYAVCGIDQKLAVAVNYQVRVYDIESIRDDTYKMRFIASYGNAFVVVSLTSVGKILVVADFLKSAIYLQLDTERGALTQVGYDTAQRWSSLVVALDDGNEETFTTLGADIRFHLFALDRTSSGITSRTLAQLPDNVSAIERAKTRSGDKLQPLAIYGTSAGAICALASADSSYEGLNGGRVKVRQEVGTRQDQNVVDGDILSAHDDELQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6P7</accession>
    <name>I4Y6P7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPRY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960302.1">
        <property type="nucleotide sequence ID" value="XM_006960240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6P7"/>
    <dbReference type="FunCoup" id="I4Y6P7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6P7"/>
    <dbReference type="GeneID" id="18474488"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61370"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y6P7"/>
    <dbReference type="OMA" id="MASHNSP"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="137"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="531" mass="58295" checksum="F4441C6E78AF29D9" modified="2012-09-05" version="1">MASIYSHSTGSSLVIVLPLILLFSTLTFLFLLFSLALLVLRLKKRSISLSNGGRYRRLTRLTNSNNQLFLPFNDDHLNLAPIDLTDMDFDNGLAGWATEESGGQQAAIERYYNSLQQPEMMGIQRARDYQEAHPPASLATAITLSQYLTIQEKGVSAWSFEPDYESLPPILVQARTELTFLADGEGLSPSEGGACSVQTNLPIPRSNDTYYFEAKLFEITPSTKVSFGLATKPYPSFRLPGDCKYSVSYDTEGQAAYNYPFTSHTIGSPLLEGDVLGIGYKPRTGTVFFTRNGKRLDPAPYDGAFHAFGNSNAEGVNPLDLFPTIGSTGAAVVHVNFGQAGFVFIEANVKKWGLAPMSGTLAPPPAYGHNSGSLLLESAANKDTEDSENDERRPLTFDERRRLERRLNERLKAESEGKDDIDPGVGTSTTNRISTRPEDDGIINNPPTPNQLDISLTELERRRSTQALNEQDNSQDEAVEEEVPSEIPETAESNGDAPPPHYAPIDPQRYPDGVSLTDIPSDELVRMIGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Q9</accession>
    <name>I4Y6Q9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960314.1">
        <property type="nucleotide sequence ID" value="XM_006960252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Q9"/>
    <dbReference type="GeneID" id="18473040"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58630"/>
    <dbReference type="HOGENOM" id="CLU_1031352_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Q9"/>
    <dbReference type="OMA" id="QSMTHIL"/>
    <dbReference type="OrthoDB" id="3362805at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="31009" checksum="70F08B53EE898BF9" modified="2012-09-05" version="1">MNKIFTRQITDDSDDNGDKPNPKLYIVVFLLIICLLLVVSSAVVARTWYIRRRAMVLGLDYPPQTGLFPFFNGHMNSNNEGSEMENLGQLGKKPELFEVYLDRDTTVQFDKQRPFAATLSVPQEMISSLNPSDQPESDSDSYLPNPSWYNASAQLARFSRTRSRFWPPVYRGRDAQYDRRRRLQALAELARERQEEERQRRYAERNPTKSLPPPIKENVTTPSISLSMLVELPTKNKSVDELPDLVIGLSETKLKQSATKDVEQLVRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6W5</accession>
    <name>I4Y6W5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_40920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960215.1">
        <property type="nucleotide sequence ID" value="XM_006960153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6W5"/>
    <dbReference type="FunCoup" id="I4Y6W5">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6W5"/>
    <dbReference type="GeneID" id="18472197"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40920"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6W5"/>
    <dbReference type="OMA" id="PDRMQSV"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="302" mass="35198" checksum="3BA7A38027F01AE3" modified="2012-09-05" version="1">MPLTAGLSYSRNKPDQPVKTKRDRVLDQGEDPFKHNAWDNVPRPDNEWELVQPHILFHREHKAPEGKVERINSNPSNYWNEFYKTHESSFFKDRQWLGLEFPDLMTLVGDKEATRDYRLLEVGCGAGNALFPLVESNSNPRLHLHGSDYSEQAVEVVKNNAMYSNPPCGKVSASVWDLSDPSAENLPVEENSCDYILMIFVMSALHPDQFSTAINNVYKLLKPGGKILFRDYGRYDLAQIRMKKERLLQENFYCRGDGTRVYFFELDELNRLFNDHGFTTEKSESDRRLLINRKEEKKMYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6X0</accession>
    <name>I4Y6X0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_70386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960220.1">
        <property type="nucleotide sequence ID" value="XM_006960158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6X0"/>
    <dbReference type="FunCoup" id="I4Y6X0">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6X0"/>
    <dbReference type="GeneID" id="18475725"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70386"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="InParanoid" id="I4Y6X0"/>
    <dbReference type="OMA" id="SDNFVKP"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
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    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
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    </dbReference>
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        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="558" mass="61156" checksum="FEC2E39940349FFA" modified="2012-09-05" version="1">MSGWKIKAEKKKSERDNAIKEALTKLPEDKYEVDVKIRELSATALAKKVANKEYTALRTVEAYIRGSVEAHERTNCLTEVLYERALEIARALDKHQASTGNTIGPLHGVPISVKDMVNIKDVDSTIGFTNWIGNRATDDSAIVKILVHAGAIPIVKTNIPQTMLSFECSNPLWGRTVNPYNKDYTSGGSSGGEAALLASKGAAAGLGTDIGGSLRIPTSYCGTYSIKPSFGRWPLKDMKSVVAGFEGIKATVGPMTRSVEDLELVARTVFNSTILTDVAESSIAPVPYRTIELPKKIRFGYYTDNNFVKSSPAVRRAVFETVEKLEQAGHECIDVGPVDAESAMEIFIALSAADGFKTLMSPLGGDPREPALFLIALGAKLPSFIRHLAAWALESFTPNAGFAKVLRESGEKSVQDYYRWTTKRNEFAKEFRNEVFKKHKLDGLIAPVQSMPNVPHTLTKYLNMIAAETITYNVTDSTVGVLPVTKVDKNLDQLPSNYASGKSARAQLLEDRMYAGKEPVYNADKMHGLPIGIQVIAEKAYEDERVIELMKVIDSLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y702</accession>
    <name>I4Y702_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960252.1">
        <property type="nucleotide sequence ID" value="XM_006960190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y702"/>
    <dbReference type="GeneID" id="18474476"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61349"/>
    <dbReference type="HOGENOM" id="CLU_729984_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y702"/>
    <dbReference type="OMA" id="CEDADFY"/>
    <dbReference type="OrthoDB" id="3360229at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="370" mass="42900" checksum="B5921155F66680C0" modified="2012-09-05" version="1">MDRIERRSLIDVVDNSIIDLADKYCRTVRKATKPGASHELRAGTTSIPWICTMLAAENLGLLSQFDETVALSRSATRPKDFKMVVETCRKILTIEEDKSEEKAIAKIEITPDELVLEYELPRSRIDDCKQLLKLFYAAVEVEKQQIYVDNVKGQYKNEVLSAVFWSMGASLNVHDLPTRNQFISDWQLTRPFHKYAEDVDYYLKEDLDSLRKTGELQRKSSPKRELGLEQSLTTNTKRRRTAAEQADIKRQPTQTTTRNQQNRTRTNDALQDLQSRRIIPQKAKDVNTTPQKPATKSAEAKQTPRRAVARAMRQQRLETVKENNDNDEDQEDDSLFINRWCFTDTFRSSYQDSRWDRFLDVRSSLVDKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7A2</accession>
    <name>I4Y7A2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960178.1">
        <property type="nucleotide sequence ID" value="XM_006960116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7A2"/>
    <dbReference type="GeneID" id="18474452"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61307"/>
    <dbReference type="eggNOG" id="ENOG502RVEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507351_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7A2"/>
    <dbReference type="OMA" id="QWHGGYS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="493" mass="51330" checksum="0199A6D7B4BF40F3" modified="2012-09-05" version="1">MSRLIKKQVAGTVGSTAGTAGTAGGAGTAAGGASSGSYNDGSYHGVGAAGGTSGASNGAANSAGSAAGGTTGSTTSGTAGSAKGSTAGETADSAGSAATSAKAPTADTADTTTKEPVADDEDLPDDDPPADEKADLPDDEIKIPDEDNTEEDLDATKSVNNSIEHSLSSSSQSESPTATPSMSASKEEKDEDDNKGLKIALPIILGLLFILFMIWVGKRVVKKRAAAKKENPTKIAYNSNIKSQETLDEKSPLPPPGFQGHSVDNRGSVYSNYSGGQPLMHPNSSASHSDYLSAYHQNMSTHSFNNLNGQRRQPSPVPPYGQHPYSGMMNRSMSMQSQGPPPQPQRPPMSSPPPPPSVYSLNKIPTSPPKPEHQTRDPFRDPPTRQYSMNRGSNVPPLHIRPPGAVRARVSFKPTATDELAIHKGEDVQVLRRFSDGWAEVKALASGKTGVIPLQILDDQPSTPMSYGSQQSSPGYQPQGQAGFPPAPPSNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7B8</accession>
    <name>I4Y7B8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_40597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960002.1">
        <property type="nucleotide sequence ID" value="XM_006959940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7B8"/>
    <dbReference type="STRING" id="671144.I4Y7B8"/>
    <dbReference type="GeneID" id="18472181"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40597"/>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7B8"/>
    <dbReference type="OMA" id="LWVHQLQ"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000051">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="244" mass="27998" checksum="9596807F1255CFEA" modified="2012-09-05" version="1">MAAKTDYELIYWPIPGRGEFIRLCFEHAGVSYVDTPGGIDQVMEYVSGDVDIGNNNIAFATPILKDNTNGVAIAQTPAILLYLSTRLGLSSDDEIQKIQIHQHALTALDLCSEAHNTHHPISANLYYEDQKVESERFSESFRNERIPKFLTHFETILSKNLKAQKKYLVGDHITYADYALWQVIDGLKFAFPKRMQTLLPDYKNINAFYDNIKSQDHMLSYLKSDRRLPYTDGIFRHYPELDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C3</accession>
    <name>I4Y7C3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_21628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960007.1">
        <property type="nucleotide sequence ID" value="XM_006959945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C3"/>
    <dbReference type="FunCoup" id="I4Y7C3">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7C3"/>
    <dbReference type="GeneID" id="18470893"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21628"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y7C3"/>
    <dbReference type="OMA" id="FHFEYDM"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="247"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="527" mass="59689" checksum="B5B0B55FBBDF575B" modified="2012-09-05" version="1">MGRGTPPRGPPKQSLPVRTSKVTQKHVLLPDEIQTRPLPYEEARRPPTNIEQQQQQEEVEARFRLAERMSKEERENEGHHRLTAYAVGERYKMKSLAAFSKREHGAWARQYDEAIYTVYHLPLLPGYSATTTLRSSAPIMSPGGGSIIDQYEEADELPQHAEIEHHNEQHYDDLSHSPPRIDHQGFINETVGDGRSGNGVSNIGDVSPSPDDVAVHADMKSASHKTQRQKRNWRRRLESINDTVAEIIHFDYGVSVFYNMTEAQENDILHDMVNAGVVVRPLQPENREIEQCHYGQDSNIPSSRIFNDFFTFKTNSHYLKLSLAHALAQSTKLSAFEELTLGVLDSASTIPKELAATGTLALDRRQAIQLTGKLFKLRVDVNLVSNVLDVPELFWSEAGLKALYDAGREYFEIGARVQTLNERLAVASDLLDIIHEHVNEQGMSRITIIIIWLIVIACLVAVGEVWIDKRHADKLTEHIGWRKINAACVAAWQCDDDAAFNRLSWSGGHPTSHHRRTKTRTKQQLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C4</accession>
    <name>I4Y7C4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960008.1">
        <property type="nucleotide sequence ID" value="XM_006959946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C4"/>
    <dbReference type="GeneID" id="18473019"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58448"/>
    <dbReference type="HOGENOM" id="CLU_118232_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7C4"/>
    <dbReference type="OMA" id="ASHFNQE"/>
    <dbReference type="OrthoDB" id="3406504at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="200" mass="22624" checksum="F2B9FB24F693AD90" modified="2012-09-05" version="1">MPKVIQLDREIVQDYIERGDLRSNDLDLLNSSLQTTLRYVGFGAVVGGGSLFYLARRYQRRWPLPTFAGVVSGTFLGQYAGAMSFASHFKAEGRDPRLVLQTLATISRESDIKRAERAAAGVKNRVSEPQHTSRWDQLRDTPTVDNKRSNTNNEKDTIKNTPDSSSQSFYDTNNFPRSSEDFSAFNREVKSYRSATEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D9</accession>
    <name>I4Y7D9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_21498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960023.1">
        <property type="nucleotide sequence ID" value="XM_006959961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D9"/>
    <dbReference type="FunCoup" id="I4Y7D9">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7D9"/>
    <dbReference type="GeneID" id="18470890"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21498"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7D9"/>
    <dbReference type="OMA" id="KEFMKYQ"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="6">
        <location>
            <begin position="262"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc knuckle" evidence="7">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117759" checksum="2D710CF64E0272FC" modified="2012-09-05" version="1">MDEDLPEEEETLKGTPSQSKARGEDDDYDEDYDAIDEQPYEPEEGDMEEIADKEEEAKKIDVKEIFPAFDADKVLNFTHLFSNRGQKRRKINSNRKVIQPPHIHVHFQQAPSTKELFNRPLPPTVPKPTYIDHLVSRIWNPNVQRDSKWKKEEPSGEVKDTKEMTLVDLADWEDDIKWSAGPEVPLHIKNGIPMIATLPPNSSLMDDDWTKSIIFNEKQKPQQSFVKLTLDMNDPSLMFEELDESSQQPATNALTSTSADPFNLSNDHLYEQSVTAPKHRIRQTFSQIDVQHAYPALKLQLPFYKTRLSKNEARSFHRPILMFPLNVEQRFAKVRSGKKKKDKEKRRAAKVDGGAELLHTTKDLTLKDGTNYALWEYSEEYPSIMSNFGMGSVLVNYYRKKDQHDDHVPKSDFGEPFVLDVADESPFMKLGFVDSGQTIPTLYNNLIRAPLFRHQANPTDFLVIRSTSRHETSYFIREIKNVFLVGQTYPVSAVPGPHSRMITNTTKYRLQAIAYKLLKRTKGERLILDRLWKYFQDQNEMQMRQRLKEFMEYNRKGEHAGYWRLKATAKIPENEEILKLVSPEHVALCEAMQVGQRRLLDAGYGNVEDESQDTTAGDETKLSIEQQLAPWITTKNFVNATQSKAMLKLYGEGDPSGRGEAFSFIRVSMKDIFLRAGEDPEKIRAEVDNRPKHAHRYTVAEQQKVYKEEIARIWKAQFKALSNPIAPKLDRKDEEAFASHQRAQKEADEEKEKAKSQHGTKILKIRRLVVSQINGSWQTEMIEDSAVISAYVRKRQIIEDQSLDVDKIEPTGDEELDRRRAKMIEEKINLMRRNQERRLQRKNQQLTSAGGEPLQMKTTTKSDTTRKCGNCGQIGHMKTNRKCPLWAQFHGPNAQPSPNAAAQLPTPTVAATPGIVSGLPSTIDANNVAGFGTPQNQGPTPAGGSQPGTPAGANQSKIKLNVGGNKSSTQSPQPAGMQQLPPQFLQPQQILQAQQAQQFAQQMAQQQQQQQQFAQPFPFPFPLPNQDQQQSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L0</accession>
    <name>I4Y8L0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family 3 O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_33367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959559.1">
        <property type="nucleotide sequence ID" value="XM_006959497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L0"/>
    <dbReference type="FunCoup" id="I4Y8L0">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L0"/>
    <dbReference type="GeneID" id="18471662"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33367"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_8_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L0"/>
    <dbReference type="OMA" id="QEIITCH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="24176" checksum="62BED2A7750BED05" modified="2012-09-05" version="1">MLTETAIFQQVDEFAEGKLIGNDPALSYALKNSAKNGLPPISVSATQGKFLMMQAKLIGAKRILEVGTLGGYSSIWLARSLPADGKLISCEFNPAFADVARDNIRNANVSAQVDIRTGPALDTIVTLDDNFDFVFIDADKNNSPVYLTEAIKRTRKGAIIVVDNTVQNAQRFLDPTEDSPNVIGNRQVYDLLQKHEAAGDLIATHQQCATGKGSDAFVYAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8M1</accession>
    <name>I4Y8M1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exosome complex exonuclease rrp45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_39981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959570.1">
        <property type="nucleotide sequence ID" value="XM_006959508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8M1"/>
    <dbReference type="FunCoup" id="I4Y8M1">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8M1"/>
    <dbReference type="GeneID" id="18472146"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39981"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8M1"/>
    <dbReference type="OMA" id="GPQFENG"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31314" checksum="C7F844D8D173D1E7" modified="2012-09-05" version="1">MVRKLDVNLNNKEFIVNALKENKRLDGRSLLEGRPIEIQFGKPLGSVTIKLGECSVMSSVSCTVTQPTPERPYEGQLNISSELSAMTTPFYEPGMRGNTAEEEATLNRQLDKAIRRSGMVDREALCIIGGEKVWSLNLTLHYISDDGNLIDAGVIAAAAALLHFRRPDATVIGNEVTYHSEDERVPVPLAINHTPISFSYVFFDDFDNAVLDPTALESQLSSATFTITTTPQKEVLTITKNGGTTFAPQTVLDCLGHATERAAVISKQLHTAINEDLDRRKIGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N8</accession>
    <name>I4Y8N8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_61007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959587.1">
        <property type="nucleotide sequence ID" value="XM_006959525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N8"/>
    <dbReference type="GeneID" id="18474281"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61007"/>
    <dbReference type="eggNOG" id="ENOG502R1M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799741_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N8"/>
    <dbReference type="OMA" id="EDLIYME"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="334" mass="38719" checksum="72150476A3A55AD1" modified="2012-09-05" version="1">MVNNKKKKATRACFSCQKAHLTCDDDRPCNRCVKRGLADQCKDGHRKKPKYIMDDQFQSNSANSEYNVLNELLGSMEPANTRRDQLASINLQPINQSIENLDVYNQVNQRYPYELGYKHLLNYLKFNNQFSQLEKLNVFKALAEFRPSLLSLQLNLNEQDEIFAEKSFKRSILDIDNLIKSISAPTVVWRRTGEISLVGDEFHYITGYDKNLLLNKPTYIYEIMEPTSAVEYWQQFSKHAFDSTSPTVNSHCILKHANGSPVPCTFSFTIRKDIFDIPSYVIGTWLPILPHEPDESDDIKFESDEYEIDQDIEDKFIDQQSFIEPNAIYQNDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8W7</accession>
    <name>I4Y8W7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_60902</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959435.1">
        <property type="nucleotide sequence ID" value="XM_006959373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8W7"/>
    <dbReference type="FunCoup" id="I4Y8W7">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8W7"/>
    <dbReference type="GeneID" id="18474236"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60902"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y8W7"/>
    <dbReference type="OMA" id="ISPPVWQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="464" mass="52918" checksum="5E1D429902BEABF4" modified="2012-09-05" version="1">MSNESGTKKLTGWELYEALGRPKKIVAPMVDQSELAWRILSRRYGATLAYTPMINAKQYSQLKTDSSKKIWFDKINNEEGADNLDRPLIVQFAANDPKLLLESAKDLQGKCDAVDLNLGCPQHIARRGRYGSWLQDEWDLIHSLINTLHENLQDIPVTAKFRVFDDVNRTVEYAKLLESAGAQILTVHGRTREMKGHNTGLADWEKIKAVKDAVNVPVFANGNILYQEDIEKCLKATGCDGVMSAEGNLYNPAIFSEKASHPYVVKVAKEYLDIVDSLKTETSVSAQKAHLFKIFKPCLSKWTDLRDRLGKGQPKDWRGIVEEFETRIKSDAEFKNEDELSDVKDLDEQGYRTVPYFYAQPYLRPTNVDNIEVEQNIDVKQQIENDIVPQREHLAVKETPVCVGENCTAAAFQKCTRQACLSCCRLFGKNIGCEVHEEKQNKRKETREIKKQNYRERKKARIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Y1</accession>
    <name>I4Y8Y1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_5046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959449.1">
        <property type="nucleotide sequence ID" value="XM_006959387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Y1"/>
    <dbReference type="STRING" id="671144.I4Y8Y1"/>
    <dbReference type="GeneID" id="18472527"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_5046"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y8Y1"/>
    <dbReference type="OMA" id="FALWMCQ"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="100" mass="11721" checksum="07A27A8E8119AC7B" modified="2012-09-05" version="1" fragment="single">DLGHSSWKLLHHLTLRFPEHPTHEESKKLEQFFYLFSELYPCDECSHHFQQILSKFPPQTSSNHDASSWLCGMHNLVNQRLNKPSFDCSTLSDHFDCDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A2</accession>
    <name>I4Y9A2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959338.1">
        <property type="nucleotide sequence ID" value="XM_006959276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A2"/>
    <dbReference type="GeneID" id="18474208"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60854"/>
    <dbReference type="HOGENOM" id="CLU_763337_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9A2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="40706" checksum="94D5AD07185E6EC6" modified="2012-09-05" version="1">MIAADARLKAPNQEIANSRKSHRSLVAFGVNIPNEIDKHREFSLIDAADGFGIWSGVGQEYNAKSIWEEAISCRVRGEKYDFSSKKIVMPETKAPSIGTISTPRITSNRHNLQSDTQDAKELKLWQESPFPPQSPSAMRKRYAEVSTPKRGRKRKHRDSVVESAKKVPGRGRGRPPKNKADSSDVKGEKETEKKPTIKGNGITYVYGAFRGRRKITDPLVQSFIAANKISENDLKKVEVPTKTKSQAVEEHRSVAAELESTPKKPESSAKMPRSTLDIIESSQENLEITPGQSEWTPQKSQSTPIQQNSIDNDEENQTSPKKTTKKSKRSENPPRKKQNESKSSLHTQVHHKMRDGNGRFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9E4</accession>
    <name>I4Y9E4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959376.1">
        <property type="nucleotide sequence ID" value="XM_006959314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9E4"/>
    <dbReference type="FunCoup" id="I4Y9E4">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9E4"/>
    <dbReference type="GeneID" id="18471638"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33218"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="InParanoid" id="I4Y9E4"/>
    <dbReference type="OMA" id="IGELFCK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="492" mass="52223" checksum="2FB82855BF95F494" modified="2012-09-05" version="1">MSTIAKTPELNNTNLWKSKGFINNEWVESDSGSTFPVTDPGNGNLLGHVPEMGVSETRRAVDAASEAFKTFSKTTAKSRQDLLNKVFALINENADDLAKIVTVENGKPLADAKGEVVYGNSFFEWFAGEAVRTYGDVVPAANPDLRNIVIKQPIGVCGILTPWNFPIAMITRKLAPAIAAGCTTVIKTPAETPYSALAVAHLCKEAGVPAGVVNVVTTDKNVAEVGKEVCENPAIKKVSFTGSTRIGQLLMQQSSQTLKKLSFELGGNAPFIVFDDADVDAAVAGAIACKFRSSGQTCVCANRIYVQSSVYAEFASKLAQKVDAFKLGYGLDEGTTHGPLIAERALEKVEQHVDDAVKRGAEVLSGGKRVGGNYFAPTVLANVPEDALVNCDETFGPLAALTKFDTEEQVIALANNVDVGLAGYLYSRDIGRVWRVSEGLEVGMVGTNAPILSQACIPFGGQKMSGFGREGGKQGIEEYLTTKLIAMGGITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9E6</accession>
    <name>I4Y9E6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959378.1">
        <property type="nucleotide sequence ID" value="XM_006959316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9E6"/>
    <dbReference type="FunCoup" id="I4Y9E6">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9E6"/>
    <dbReference type="GeneID" id="18474219"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60875"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="I4Y9E6"/>
    <dbReference type="OMA" id="QYEGTML"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002709">
        <property type="entry name" value="Probable iron inhibited ABC transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="69"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="381"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="618" mass="68566" checksum="2D96833368AC2597" modified="2012-09-05" version="1">MAPLSASKAKRLQDKEAKAAAKGKSTTKSSKPASESTGITDGSEMKKLSVATDRSTAGVLVSDPKGRDVKLDGFTLSFHGRLLIESAEVSLNYGQRYGLLGENGSGKTTFLQALADRDIEIPEHIDIHLVAGEAEPSEVNAMDFIIASAKEKVIRLEQQIEDMSTADDIDELALESKMEELEELDPSTFEARAGLILNGLGFSQAMMAKPTKDMSGGWRMRVTLARALFIKPHLLLLDEPTNHLDLEAVVWLEAYLSTYNHILVITSHSADFMDSVCTNIMDLTNKRKLQYYGGNYSIYCRTKSENETNQMKAYAKQQEEIQHIKKFIASAGTYANLVKQAKSKQKIIDKMEAAGLIEPVEKPRPLRFNFEDIRKLPPPIIAFNDVAFSYSGKPEDYLYKDLSFGIDMDSRIAIVGQNGTGKSTLLNLITGVLQSVEGSVSKHAGLKLGKYSQHSADQLPYDKNPIEHLESSYKEKFPNKDVQFWRSQLGRFGISGAHQTSPISHLSDGLRNRVVFSMLAMDQPHILLLDEPTNHLDMESIDALALAVKEFEGGVVIVSHDFRLISQVAEELWEVKDRKIYNLTKSDVNIQQYKSMLQKKSEASLEKAKLGGAGKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K1</accession>
    <name>I4Y9K1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959426.1">
        <property type="nucleotide sequence ID" value="XM_006959364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K1"/>
    <dbReference type="GeneID" id="18472987"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58109"/>
    <dbReference type="HOGENOM" id="CLU_1103500_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9K1"/>
    <dbReference type="OMA" id="STQHTYK"/>
    <dbReference type="OrthoDB" id="10544149at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="252" mass="28658" checksum="8ED765792D83F763" modified="2012-09-05" version="1">MKQNDFRNLLREKDKFKNIGKQNGLNLELLNQQKDLKQERNLDNFSSSLNDIDNTDRSSKLNELNTTKRKRNRDDILLELKKSKIDSLNDDNNLDSEVAKYIPPKHEALNSDDDIFNDVGDYNPPSDNDNSSSPSSSPHPSPHPSPRFSPPPSPLPDSVHSFSPSPTPELDDTGRLIGLSSSALPNISQRIEFDKQAEITESRKQRKQVWLAKQGIRKDTGEQQAPLPEKKQTDSQKLNSDYQRINAFLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA37</accession>
    <name>I4YA37_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959091.1">
        <property type="nucleotide sequence ID" value="XM_006959029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA37"/>
    <dbReference type="GeneID" id="18474978"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64991"/>
    <dbReference type="HOGENOM" id="CLU_1074436_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA37"/>
    <dbReference type="OMA" id="YLLGCTH"/>
    <dbReference type="OrthoDB" id="10487106at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="259" mass="29013" checksum="E8681CEE7E737604" modified="2012-09-05" version="1">MLTRKSHHAFCGLITVRTSTLIYSTTTFLTYAASAYAAFNLLTLSCPHCTTSPSNSHQPSNILDSADAQARFGARILIVSIWYAITMVVGSSFGIWGVVKENIRNLKLFRLMHAIDVILSFLVTFVDFVCDSPTRLESNNCWEIWKSSVYRFIGLMLIIIIFKIYLLASTHIYIRQCQLKQRKLRPRPSIVLVPPPPSSNTRQLTGYIVASPTTTKHKKSHSIRQASVDVSNGGPIALAIRPDEGLLPHERSYSDEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA56</accession>
    <name>I4YA56_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959110.1">
        <property type="nucleotide sequence ID" value="XM_006959048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA56"/>
    <dbReference type="GeneID" id="18474129"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60733"/>
    <dbReference type="HOGENOM" id="CLU_1732907_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA56"/>
    <dbReference type="OMA" id="NSHDEIH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="17234" checksum="A112C212AA691CB6" modified="2012-09-05" version="1">MSSVIEPKNKYFPAIIVAIVVGACVVFMIAVWITQQVLKRKPNVEEKRQSYYPEDFYHGYNKKAPNTKNEIEEEDVQDVEKAVPRPRPRPRKTDSESLPTRPETLYSPTRPNSTLLLDEFVAPLFDNSSNNHSNSNLLKNSSHNSHEGHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA75</accession>
    <name>I4YA75_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_65027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959128.1">
        <property type="nucleotide sequence ID" value="XM_006959066.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YA75">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA75"/>
    <dbReference type="GeneID" id="18474983"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65027"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA75"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="3031"/>
            <end position="3094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1562"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1723"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1573"/>
            <end position="1585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="3166" mass="357099" checksum="3A59636A348F0F46" modified="2012-09-05" version="1">MLEGVVAGLLNRFLSAYIDNLDYSQLNVGIWSGDVKLKNLKLRKSALDKFRLPVDVNEGYLGELTLSIPWSNLKGKPCKVTIDNVYLIALPAGASQFDPEEDQRRAQQVKQERLESAEILLNSQASPGMSPEEEQKNQSFANSLMTKILNNLQVVIKNIHLRYEDDISAPGSSFAVGLTLGGFSAVSTDDNWVPTFIEEGQTGIRKLAKLESLAAYWDSDSTSLVGHPTDVAIKKFTELIAHKDNNPSHQFILKPVSGEGRLTMNQNVDSISPKIDLELLFDQIGFLLDEQQYRDALLMVDTFHFHIRQSQYRHFRPSEEALLENKPRALLKFAGKAILNEVHERNRKWTWAYFAERRDDRRLYVELWKEKKENERLQKPAERSEELVKLEEKLRYEDIRFYRSIARSELRKEALKRQEEQGESAHTPSQSQAQQGWMGWAWNAASWAVGSETQSEENKGNSTALSDQQRKELYDAIEWDEKQALSSAVDLPRDAMKLRIKAKLHTGSLALRRPKMSNDDIVSVVFSALTADIVKRVDNTSVAVGLGDLNVRDATNPRTVYPNIVRVKRDVSGEVKDLNEAVTNLAIEGDNDVDGSEKSGSATPTPDDDKNKQFFYFLWESKPLDNRADSALQLKMRHMEIIYHKGYVEAIRNFFKPPESKLESINALIDVASESLDSFRKQTRAGFEYALAQHSTIDLRVDMNAPIIILPEDVTNKRTMHLVLDAGHIAIESDLADKKAIKDVRHKAHNQAEYGESDWKQLESLMYDKFFLKLKSAQLLIGDDLPVLLDVLEKKTESEINYNIVEEINIDLTVHNSILPSAVNLARFKLAGHLPELTINISDKKYQSMMAIIDVAIPHFENDNGKSPKKSTQSTGQHGRRNSIFAADLPAYDLDVHDEESEISDADTAEKFFEAPESGADEGSYRQQVFTLDFRVDKLQANAYRSGQDGQERQLAMGILKGFYLGYVYRQLDMHVDVVLQSLSIVNIERDGQHLPLITSESNDQLAQLVRVKYDRVQSESPEFHSHYDGIDQSVNADLSTINLLARPEPIIELYAFIMETFVGGRNTNNSSDDNGSSDELVASPSNSQLEEQKDVPSRKIKVDFKLSSIVFKLDDGMRQLATLILSAGDVSILLDGSTMKVAAKLGGLEITDDSQKDEEFKQMLSIEGEELADFNYQTYDPNSGEYPGYNSAIYLRTASLKFTFNEKPVNDVYKFLIKFARLKALYDAASRAAADAANEASRMQYDVRVKAPIIVVPTSTHDMLTMRLGEFVAQNTFTGVEIGDTQNLHTGLHGINLTSRIRDDDGLTETLPILDNVNLDFNFEIFDKVSSGEKARNAMQKIHGHMTDVKVALTQSQYVSLYDLSKSIPAAFTIDDEQSIEEDAEKLSIPTETKKAVMKDQQFKSVTKKPSVDLNPEIMISDDLWTTTELSFDVGTVSLELFTPLATSASKLKENSIARFALNDTTLKLKTLSDGAMESELTLKSLRMDDTRAQSATKFRQLIPPAVHDGHQFMVHYSKSGGTEQSSLALVTIDSPKIIFSVDPLFALTEYFWSALPVENEPDQQTDHQEDLGENLDDDNDNENLESSSTRPPDDINREPSFAYRLNIVNTSIIILANESEPTTEAIELSVKQVLMSQQGVIALKVDKLGMFLSRMDKPKEKLRFLDNFDFTLSYDSRKVDLRQNTSIELRAEPIIFRASYRDIMLITEIFNKAVELSTKSRPTATSGDLRESESLRMMPTDRSSSQLALPAPPSAKPKVIITKENLNAIFEGFQVVLIEDLHELPLIHFYTKKFNIELFDWSSEMKMQTAISWAINYFNPTNSHWEPLMDPWEFTLRGERRQPPAGMNITLSSRKRLEINLTSAFIQTALLFYSLVGNNATRLLEKPRGSSAPFLLRNHTGYDMGVWPTHESESVSPLANNTELPWRFEDLRTLREDVSASGHNSLGIQLDNTKWEKIGRISVDKEGQQTYILKSKISKILHRVVVDIKLQDTFKVVTFRSAYLIENSTHLPIEVVIIGGNGKPTSASTKVVPGDSYALPIEAAYEQRIKLRPDPGFDYGWSSEALYWQDIMKRPARSISCKSNNAGEPSFRFQACADYDQSDELTQIYPRLTLRLRAPIEIENLLPYDIKFRMFDKNTKQDWSSFLRQGGVSPLHLIELTHLVLLSVSIENSVFSPSEFAIINTDNPDDFPVENTLSLSDQDSLKLNVRIHYYRYPKSAGAFKVQIYSPYVLYNKSGLDFVLRSKSLLGAGKNVAGQDLTSSKIKKRETSPFMFSHNSDDRQKRFLLKIGDSNWSKPISFDVAAADTEVTLSAQGGENVHIGMSVVEGNGKYKLSKVVTIQPRFLIKSQLNEPINVRVDRSSNLVNLKSFERKALHRLEGIDEDERHLLRIAYPGTQEWSAPFSLTDVGPVHLRMRHSDRTEHLIKADVYIEGPTIFVYLKRDTDPWPFKIENNSDSGIEIWQSTTEGYDNLSMMPGLKSKRYRVDPRSSMDYAWDAPAETDKKLRLKAQGGKERSIDLMEIGALPPYRFASDTLSIDVRADGPRQILVLSHYSQDESLYQPRKKSVSRSEASDSTAGLFEEKNVETIMNTQFNLELEGIGISVLNKRMQELFYASFRGIGMQYSDTNIHTSYNLSCKWIQIDNQLFGGLFPIILYPTTQPKDGRELERQPTLDSSVIVSKDYSHGVTRIEYFSMLLQSMTIEVDEDFLMALIDFSKFEGPSWDQQQEDSLNENPTDIIEPADLGSGMQLYFQVFHLQPISLDLSFMRTDRVNVDNKTSAHTRNPVMFFINALTMALGNVSGAPIRLNSLILQNARFTSALLSQHIMINYREQFMYQLYRVLGSADFLGNPVGLFNNVSSGVADIFYEPYQGLVMHGNKELGIGIARGATSFVKKTVFGVTDSMSKVTGSIGKGLSAITLDQEYQSRRRMTQRRNKPKHALYGVTAGANAFAVSIASGFEGLALKPIEGAQRSGAGGFFKGVGRGLVGAVTKPVIGVFDLASNVTEGIRNTTTVFDPQDIDRVRLPRYIADDGVLRAYNERESLGQSWLKNVENGKFFNEIYVAHLNVRGTDAVLLLTTARIVEIQVRSLQLRWEVAFDELHSISLENHGISLKLKGNLAGPFMHLSSQESRTWFFQRIQSVVNNYNYARSKPIERQQTPHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA86</accession>
    <name>I4YA86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_29327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959138.1">
        <property type="nucleotide sequence ID" value="XM_006959076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA86"/>
    <dbReference type="GeneID" id="18471095"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29327"/>
    <dbReference type="HOGENOM" id="CLU_1556471_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA86"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="19694" checksum="5B8D3E9CB37E3B38" modified="2012-09-05" version="1">MSESFEIHNFTRALKPREKEYVMGKLPKTLGEAHQHALDYEKTTGRNHTNSQKKFGTPNFGFFIPPPQQRKFDEAVPMDLNTTKTGRMSKIQCYNCRQMGHISRQCPHTGRTKQVNLTGIDVDTPEDKMITVPVRTYGEERRGLLDTGASADFVDKKFVERNNGKMYGHVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA95</accession>
    <name>I4YA95_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959146.1">
        <property type="nucleotide sequence ID" value="XM_006959084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA95"/>
    <dbReference type="FunCoup" id="I4YA95">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA95"/>
    <dbReference type="GeneID" id="18474143"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60754"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="I4YA95"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="26639" checksum="C25B611B99E51A7E" modified="2012-09-05" version="1">MDLRSTMTHKDAERLKKGEVNLGTSIMAVAFNGGVVIGADSRTTMGSYIANRVTDKLTHIHDRIYCCRSGSAADTQAVADVVTYHLSMFGVQQGERPSVHTAAALFNQLCYSNKDRLSAGIIVAGYDKENGGSVYNIPLGGGMFRQPWAIGGSGSTYVYGYCDATYKDNMTKDETVTFVKNTLALAMSRDGSSGGTIRMCVITEDNVERLFVPGNELPRFWEGQEIINKPAHQLAMEAQGDVMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAI0</accession>
    <name>I4YAI0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_60662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958963.1">
        <property type="nucleotide sequence ID" value="XM_006958901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAI0"/>
    <dbReference type="FunCoup" id="I4YAI0">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAI0"/>
    <dbReference type="GeneID" id="18474082"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60662"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="InParanoid" id="I4YAI0"/>
    <dbReference type="OMA" id="SKTKWHF"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="358"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="641"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="711" mass="80599" checksum="26645BA667ECAA59" modified="2012-09-05" version="1">MSEIKPKRPSKIGQYEVLQTLGTGSFGKVKLAVHALTGHKVAMKILNKRKIHSLDISSRVKREIQYLKLLRHPHIIKLYEVISTPTDIIMVMEYAGNELFNYIVERGKMPEDEARRFFQQIICAVEYCHRHSIVHRDLKPENLLLDDFNMVKIADFGLSNIMTDGDFLKTSCGSPNYAAPEVISGKLYAGPEIDIWSCGVILYVMLCGRLPFDDEFIPNLFKKINGGVYHLPSYLSQETKSLLSQMLVVDPVKRITVPEIRELPWFKVGLPKYLEPLPPATTPSNEDEKKSPEDIIAEGEEISPDLGIIDRNIVNDLVEKMGPFDIEQIIEELKAENENQFKVAYQLVRDHKRMVQTAGDRQDQAMDNFLSSSPPAWNAGLEHMTGSRRSTSIKRKARNSPQDQQPAVEDNDEYDDFDGLDDYDLEERFTVLDSSLPQNNDEDSSQAYKMESLKLNDSHKSTKKDPTKVLQSRSSQPISVEPMSAMPSSTVPEERIAKDTIKHTQRGDAPVPQQSKEKSTQQQSTSVKKSKASKWHFGIRSRSPPMEVMLEIYRTLKSLGMEWKKKDLPAKPPNSNAHQDDLQIPQDLFFVETRSRIKNVIIRMDLQLYRVDESNYLVDFRLVDYFPIPPTSEDYIRFDSHENSAESSPGVKSPGEFSNNTSEGHSAPNVDRLYDANQKLQQSQQAGDVCSPFLFLDCACKLIVELAGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR4</accession>
    <name>I4YAR4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose-binding like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_19726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958910.1">
        <property type="nucleotide sequence ID" value="XM_006958848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR4"/>
    <dbReference type="STRING" id="671144.I4YAR4"/>
    <dbReference type="GeneID" id="18470810"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19726"/>
    <dbReference type="eggNOG" id="ENOG502RZAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133965_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAR4"/>
    <dbReference type="OMA" id="FFGRITV"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14564" checksum="AAD0C4D6EC0AA69B" modified="2012-09-05" version="1" fragment="single">RVSSNIDKFSNKLNLIDKSNDSCWSSNNGKNQFILIKLKNFFKLKQFNLTFQGGFSGKLCQILLYKDDDFVYQQPFYPQDNNKLQSFYLQEIFEVNKIKLLFNDSTDFFGRITIYNLDLIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAT5</accession>
    <name>I4YAT5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_19220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958735.1">
        <property type="nucleotide sequence ID" value="XM_006958673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAT5"/>
    <dbReference type="FunCoup" id="I4YAT5">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAT5"/>
    <dbReference type="GeneID" id="18470793"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19220"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAT5"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="398" mass="43663" checksum="30A29B4606DB497F" modified="2012-09-05" version="1">MKAAYSTAAPSSKIYRDAMTGEVTSLPDIDVSKLQIEKIANPKTIPPSNTLRFGHTFSDHMLIIPWNSGSGWGAPTIKPYGPLTLDPSAVCFHYAPQLFEGMKAYRDSEGNVRLFRPDMNMARMNRTAERAALPTFDGQSMVELIRRLVVLDQNWIPQEPGYSLYIRPTLIGTQASLGVGASSDALLYVICSPVGPYFKNGFKPVKLLATSKNVRAWPGGTGAFKLGANYVQGVKPQHEAAEKGYDQNLWLFGEGEELTEVGTMNLFIVVRNDAGETELITPPLGDMILPGVVRDSILNLARDPPEWLKEQLPENFKVTERRITMPELAKLAEEGRVVESFGSGTACIIASISCVNWREKDITIPVEADGSGAIATVLRNAIEAVQLGREEHPWSIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAV7</accession>
    <name>I4YAV7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_19433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958739.1">
        <property type="nucleotide sequence ID" value="XM_006958677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAV7"/>
    <dbReference type="GeneID" id="18470797"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19433"/>
    <dbReference type="eggNOG" id="ENOG502S9PZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101084_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAV7"/>
    <dbReference type="OMA" id="LGHYTWP"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15753" checksum="D1A643490B390E10" modified="2012-09-05" version="1">MKGDIVDYDRGRRSDAVDYAHKLQIWHGSMGMLKYSCYGAILMYLANLRFPWVQRQTLAGKAFVVSSFGIFGLVVSADTHLLSHERQQGSVENEVRRRALEDLSANHGIVASEGQIRRWVMEKKAEAAQEREKNLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB57</accession>
    <name>I4YB57_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958871.1">
        <property type="nucleotide sequence ID" value="XM_006958809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB57"/>
    <dbReference type="GeneID" id="18471075"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29116"/>
    <dbReference type="HOGENOM" id="CLU_1741991_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB57"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697780" evidence="2">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="16820" checksum="49B8BCCC1BCA6696" modified="2012-09-05" version="1">MLIIKIAFTIAAIVAVAHAAVFTRGETQDNKYDGKNDIKNNDNKGNNYKDGKYSSTVVYYKVEPTNAKYGGKDNYTSTTIWYAPQETGKGDYKNKYQDKDSGKDTTKDHGKESNKNSYQDALDKHQKDVEAQLNNTQEYKDAVANSANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBA6</accession>
    <name>I4YBA6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4042 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_57596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958603.1">
        <property type="nucleotide sequence ID" value="XM_006958541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBA6"/>
    <dbReference type="GeneID" id="18472929"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57596"/>
    <dbReference type="eggNOG" id="ENOG502T02Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023315_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBA6"/>
    <dbReference type="OMA" id="CSNISEQ"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13251">
        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4042" evidence="2">
        <location>
            <begin position="62"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="565" mass="64316" checksum="F2F62B6B39CB0E64" modified="2012-09-05" version="1">MQDESKTARRSASISSLRSHASDMSSDNSTNWRFRDDHASDMEEEDSFHVNIRDIRSDVILQATMCISQLAHSHVKFVFNHIFKLLPDMSLHVNPSFTLWDIINSENINQDAKLSTIQCIEQILRSSRPFLYPSADLNQKSISYTSLAYRLGSLLWESHERLSDLLSSNEDTAIQVALLNLSVCLVNVTPYSRMTSDTPTKLCAELQKIIFALNNLEQPSQVASLCLLQNVVDAGLLKEDEIYFKKMSKWLYDQVFIGDYSLVVRTQMVDVLAKIWVSFPVLRVAEDFKRLFNMIFNKDEIEFKIAAIQLLFLHPEMQEKLDDKLLTTSHQIGKDNCAFNCHFLDMLGASLGSNCLKDDILYDTVEWILEGVYSVSTDMKVAGLSATKNAFRDTRIRSNDDLAMRLEKACVDSLINTSHIVKQKAGFALADYLDVLQLHELSKSRWQRLFDIVSMMQAKDKGKAQVHVFRAYGSILEKSQGLNDESIDQAKRMINILKDELQPQLNYKIQWNAATALGRAFANRDIYESCSGVIESVVNSLQGCESKTRNMKVKMCCNNALNRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD6</accession>
    <name>I4YBD6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_28916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958631.1">
        <property type="nucleotide sequence ID" value="XM_006958569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD6"/>
    <dbReference type="STRING" id="671144.I4YBD6"/>
    <dbReference type="GeneID" id="18471066"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28916"/>
    <dbReference type="eggNOG" id="ENOG502SEUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027102_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBD6"/>
    <dbReference type="OMA" id="HDITHSF"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="386"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="663" mass="75306" checksum="00FC50A219CB4502" modified="2012-09-05" version="1">MGDVKNAIDNTPFIPISQLTINSDNNRLDINAHSNMSKQPRKSFSEAYDNKYKSPFKPFKKISNFFNNSSSTTDKDVFAETERSKALYPDLLRRAKSLDHNQSKQLKQQKQEKQEKLMRTHSRVRNKLRKTPKQETEQQDNDTNSKDKLRKRSTRRSKRKELEQSDEIHASSQIPSVPPVPPIPPVPRIPTPKSSTPSSTTFPSNSVTFTPFPGSHIHSRPSPPPRLDIPKISPFAQTLDFVSPQQNLEHSQAQYIRNNQRRDPRSPTHMLGVSSSSDHSSPTVATNSGPPTPMSNLTNLSNFSNRPQTLHLITDDNLFYEALKDYRKRSIVFGTAESDVVASLGGKSNDKHVRTPSPSPTKSNFEDIPANEDQIMSDPAWKSEVKRLFIIREIASTERSYAKYLSQLLELIKTSYPTFQTRPSTTLQIIDENGSKNPEESFKHIKLLAKHLPELIQVSQQLLQRLDDDPSAYGVAVAFISLETDLESVFINWSRAYPHVIDSISQNKLLREQKEKRNKRGKSMSFVESNKSQHSDFYLQSPHDKVESYTITKKGRVKTEPTRTTNEKSLTKKKRKQAIEESLERLTLNDSQVHQRLKLNDVAVMPSQRVTRYVLLLKGKVKLLDLSKHTPESALASGLVDRALRGAQRIANDCNEASARQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ2</accession>
    <name>I4YBQ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958428.1">
        <property type="nucleotide sequence ID" value="XM_006958366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBQ2"/>
    <dbReference type="GeneID" id="18475504"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68977"/>
    <dbReference type="HOGENOM" id="CLU_1448780_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBQ2"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="20771" checksum="0B26427E32447728" modified="2012-09-05" version="1">MDAIIGFPLDKRSNWTPGNVDETWDNYFQPYHEKVGLGFVSTVGLISALMTFGLLSYILWHAKFNYDARHPPSVVAANGSLPTFINSAPGAYLVSLFVSHFIYGVGFAIGFQWAATQYISVGPLCDVQGTFLQIGDLGYAFWSGAIAYHTFNLLYFRQSPPNWVNKGILTLLTLIDYMIIQVERGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBX6</accession>
    <name>I4YBX6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1765-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958497.1">
        <property type="nucleotide sequence ID" value="XM_006958435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBX6"/>
    <dbReference type="STRING" id="671144.I4YBX6"/>
    <dbReference type="GeneID" id="18473951"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60449"/>
    <dbReference type="eggNOG" id="ENOG502R8B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336563_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBX6"/>
    <dbReference type="OMA" id="EIACHEE"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="847" mass="97102" checksum="FA66455EDCA7305D" modified="2012-09-05" version="1">MPLTPPPRRSSRQKSDLFVHQSDENCAGSTPLSNNIHDDNHDENDRNDRDNNNRTTQHNHKLPDSKYNEENNVNNDDLFLQPKPTDNDNLPSPVFKLIDRSESPKRAYSPLPVSSESLPIPTDQQEPNQVTRIWTTIQNNLQLFKGHLQELQPNKALFIRETFNSFDSIDDCKLYDTEKVVGRRSLLFDWVYAIIDDLNSQQIAPERSACLESLAVILESKFLSSKLIASYAPQDEDRMCKVLADVVKYSLAKLNSRGVFQNTIFYCGRYFAIAFFRLPGTAQQLLQPLDVPPRTLAKLINDSGWDYESAEQLPSTSFASFLQHLCIKPSKRSNPLEIKYADEAREYIYGLHETNIPNKYLILEPDNWLRRWTSDDSELFFSFIRAYHRLLERFILEGLEESKDKYRILSTKFLFNSPGYPQLSCILHSKILSLVRGDIYSVTTGTPSNNQKSTDISETANVLAATAGKPKLLEQANRRIVLTLQDMLQNNNSTEVLDGKFTWLEVVNFQIKLAVRLTNMYSAPQVFCLLDALDGIFLTAFNLDTNFEQIDIQFVLEFITIILKNCDHVLTLIRVISFIFTHFDSLCQYPQYQRKLCLDLLLEPSLFNRLTLFWSQSVRSYWLRLLVFRVGHVQQNPEASDLVIEIIKQLNSNLNTIKRRHEDIEPSTRTNSVILHSDEEDVDDKRNSIIESSDGKNQDNNELNNSFKGLGLDNNNANNLPSTPKKKSFSFELQTPPKVSASNQNSPTQSPTNSRKSSADNGNIKPSNSNTTLRTLLPKPASLLLNGKDLNSALCSQFYYNRNLHIYATKALMEYSNIIEVEYQFQDWQSKLVPRLVVQWPAAFTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC39</accession>
    <name>I4YC39_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A-pheromone processing metallopeptidase Ste23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958556.1">
        <property type="nucleotide sequence ID" value="XM_006958494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC39"/>
    <dbReference type="FunCoup" id="I4YC39">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC39"/>
    <dbReference type="MEROPS" id="M16.020"/>
    <dbReference type="GeneID" id="18473974"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60480"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="InParanoid" id="I4YC39"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="206"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="392"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="783"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="986" mass="113839" checksum="FD4F96C61EC248CE" modified="2012-09-05" version="1">MRLYRTVMTSWKQKNSYQQFSKLLEKSNNDQRNYRLIKLENNLECLLINDNQTDKASVAIDVKAGHLLDPKELQGLAHFNEHMLFLGTSKYPVENDYQDYLSKNSGYSNAYTDMIDTNYYFTCSTNALKGAVDRFSQFFIAPLFTQSCTQREVKAVDSENKKNLQSDLWRLFQLEKGLSNAPLSNFGTGNWDTLYSEPSLKGMDPREELIKWYETHYSSHLMKLCVLGKESLDELEQLTVENFSAIPQRNIPEPQFSSNVWPEDAHKSIIFAETIKDLRQLTITFKFPEQDAHYNTKPGNFLSHILGYEGKGSLCSYLKQLGHINSLSAGFGFSAPGFEFFKINLDLTTRGVGEWKQCLKLIFNYIDMMKKFSDNPPEYLFRETQDLATIAFRFKEQGQPEKVTSSVARLMQKPYEREHILSGSHLVREYEPNCIKESLNALNLDNCRVLLAAKDPIEGVGELDRTEKWYGTKYRVDPLPEELLNEIRNTTSPSEMHLPHPNQFIPKNFDVEKKEVEEPSITPALLRDTKNVRLWHKKDDQWWVPKAHVYMIMKSPSILKSAKASVTTRLFNELLLDEMNEYAYDAECAGFAYSIESTGDGVLIHVKGYNDKLTTLLHQVISTLKNLHISEDRFNVIKERIERVYANFSMDAPLMHANVATYSLTQKVFFTFDERLEAVKSITKEDVENHAKEFLERLYLELFIHGNVTDDSAIQISKDIETVLQPASLSEEERQSLQSSLVPQGDHVYVKKVQNPAQINSAIEYYNEVGDVVDLDLRTKLSLFAQIVHEPAFDQLRTKEQLGYMVFSGMRKSIGAMGFRVLIQSERPPAFLEQRIEEFYDVTVKNLLESMTEEAFEKNKNSLMEEKLEKPKNLNNESSRLWVELSGGYYDFTRRLKEVESIKKIKKEDILNFFYTYIHQSSDKRSKLSTHLVSQSIPEQYKEFNSVESLRTSNKIYEDIPSYKTQAKTSSHAKPVAQIPKPAIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC66</accession>
    <name>I4YC66_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958257.1">
        <property type="nucleotide sequence ID" value="XM_006958195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC66"/>
    <dbReference type="STRING" id="671144.I4YC66"/>
    <dbReference type="GeneID" id="18471497"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32475"/>
    <dbReference type="HOGENOM" id="CLU_610033_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC66"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33740">
        <property type="entry name" value="GPI-ANCHORED ADHESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33740:SF3">
        <property type="entry name" value="GPI-ANCHORED ADHESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="48179" checksum="0D9C032AD172B7D6" modified="2012-09-05" version="1">MTNVDNRFLAEFEWHDASAKEVQLQGSFTGWNDPLIELTKEADGIYKTTVPVTYSAKHLYRFKVNGEWKIDETKTAATGGPLNVPINYFFAPNQPPSANKTDKKKNKKKNKKKNKGDAHDSEEEHTAGESEDNKGHAGEKAIAAGAAGVAGAGVLGAAGATAAGLAKDAPQNYAAAVKKDEDNIGDAIVREVQTPVKEEEEEYDESAQEDEAEGTKQADQTTEAQTSSQAGPNEEKVGEKSTKEDKQEEKPTDKSSGEDSNEKNQNKEASAFEGILAGSGAGALKGNHQEEKDMSAVEQSKQAVEEKKPEVAPEGVTEAATSKSAEATEEAKKTEDNAEENVLEKTNVDSSKEGVAAEVPTNAETTGKDVENKVEEAKEEAKGTADKTTNEASKIKEDVEQKPAEAKEEAKDAAKDIKEETKEGAPKKASLSKRISKRISGIFHLSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC86</accession>
    <name>I4YC86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_54451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958275.1">
        <property type="nucleotide sequence ID" value="XM_006958213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC86"/>
    <dbReference type="FunCoup" id="I4YC86">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC86"/>
    <dbReference type="GeneID" id="18472672"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54451"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_3_1_1"/>
    <dbReference type="InParanoid" id="I4YC86"/>
    <dbReference type="OMA" id="LINCWIL"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697965" description="GPI mannosyltransferase 1" evidence="14">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="379" mass="43625" checksum="3C2349167FE81631" modified="2012-09-05" version="1">MTFIVTFAALAVRVLLILYSKYHDSIADKTGGPYYTDVDYRVITDAAELVYNGHSPYERQTYRYTPILSWITLPNVSTDPSFGKYLFSFADVIVGLSIERILMKYNKKSNYVSRFMWLFNPIVISISTRGSPESLIGVLVMTTLDLILHESYTLGAVVMAFSVHYKIYPFIYSTSILVHLWVKHRSIRLLLWFSVVSLVAFAAINAAMYNIYGMDFLQATYLYHIGRKDHRHNFTPYFYPTYLTYSSDEGLHPAFSLIPQLVLALGLGVYGAIDLPLAWFFQTLAFVTFNRVCTSQYFLWYIWLLPVVLPSLKLSKRKKITLPILWISAQAVWLSIAYKLEFLGQPVFIPLWIASLFWFIINVYVLGSLIRSTRIPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCE8</accession>
    <name>I4YCE8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_64261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958335.1">
        <property type="nucleotide sequence ID" value="XM_006958273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCE8"/>
    <dbReference type="FunCoup" id="I4YCE8">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCE8"/>
    <dbReference type="GeneID" id="18474910"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64261"/>
    <dbReference type="eggNOG" id="KOG0766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="InParanoid" id="I4YCE8"/>
    <dbReference type="OMA" id="WGIYEEL"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="129"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="225"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="314" mass="34383" checksum="30ADC70D63E428ED" modified="2012-09-05" version="1">MDRKPSSEISQRLISGATSGFAAAVALQPLDVIKTRLQQVEGHNESINKKNLSSLLKSTRVYDITKAIIKEEGLRGLWRGTSPTLWRNVPGVALYFTSLQSLRSYMITTGLFLPNHTSNGKSSSEFSRLNSRGNLISGALARTAVGFLLNPFTVCKARFESNLYKYKSIVGALTDIVKQSGPRGLLSGFSASALRDAPYAGLYVVIYESMKDYGSQFNANGNNIPPPLIYSVSGLFAGTTSTLITHPFDVVKTKMQIFPNQYRTLSRSIVTILKNSPRSLFAGSGIRITRKALSSAIGWTAFEELARLLKKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCV2</accession>
    <name>I4YCV2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_37869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958098.1">
        <property type="nucleotide sequence ID" value="XM_006958036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCV2"/>
    <dbReference type="FunCoup" id="I4YCV2">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCV2"/>
    <dbReference type="GeneID" id="18472034"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37869"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_0_1_1"/>
    <dbReference type="InParanoid" id="I4YCV2"/>
    <dbReference type="OMA" id="GHSHMDP"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="303"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="368" mass="41027" checksum="6B5C0B82316D62C9" modified="2012-09-05" version="1">MMTDFDDEIPTLIDSNETVDIPDDKKVPLTILTGYLGAGKSTLISHILTERHGHKIAVIVNEFGDTADIERRAVNVGEDEEYLELENGCLCCSIRDAGVAAIAKMMRRKGKFDYIILETTGLADPSGLAEMFWENELYIPDIYLDGVVCVADAKNVLKQMESDTRRSANECVRQIACADSIMVNKQDLVDEFTLTDVRDALKTINAGATVHLTSYGKLDLGQVIDLNAFNSVTKNDKAVKSIENITHGCDEAHNHSHLFGIQSIELSLPSLTNVQYADFDMWIRCVLWENTLPSVETVEIGEEMEILRTKGVINRDDGAVYILQGVRDMYEIKQAPNGPSINTKLVFIGKNTNQDLFQKSINNYLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCW0</accession>
    <name>I4YCW0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_64036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958106.1">
        <property type="nucleotide sequence ID" value="XM_006958044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCW0"/>
    <dbReference type="GeneID" id="18474895"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64036"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759114_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCW0"/>
    <dbReference type="OMA" id="NDEPINK"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="365" mass="41068" checksum="DE0DF5E4B0107CD0" modified="2012-09-05" version="1">MIDNNSQLSSDISVNRRPTLADTNDLFNLNIKEDELHVPQRRGSRFDFASQSNNSSLGLDVNPFNYPLFPPQLPAQLQPRFYPPFDLSQQSQLPQQSQPSLNDLGKGTPLASIPPHTTLFIVEFKATRSDLFYTLDYNVASSIKLSDLVIVEADRGKDLGKVTNDKLTIEDLLNYQKYQADVALSGNSLNRKPSISPLDDAPSPTTSTINLPPPHNDAFEALKSLSKELQPKKIFAKASPSDTQLLITKRQDEAKALQICIQKVTQRNLPMQVIDAEYQWDRRKLTFYFISEQRIDFRELVRELFRGFKTRIWMSNISATASAQLVATLQAQAQAQAQVQSQLPTFINIQDPPSPLTTPTTITHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCY6</accession>
    <name>I4YCY6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative myo-inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958130.1">
        <property type="nucleotide sequence ID" value="XM_006958068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCY6"/>
    <dbReference type="GeneID" id="18473846"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60261"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="I4YCY6"/>
    <dbReference type="OMA" id="AGWTVIM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="478" mass="51769" checksum="5327CB229FE23833" modified="2012-09-05" version="1">MFGYETGIIGTITISVGMDLGVDINAKEHENKKEIITAMTGAGAFICSIFAGALSDKIGRKWVLVISDICYCIGTVVFGASYSVAQAAVGRLILGFGVGMSSCIGPMYISEISPTQLRGTLVTINSVTITFGQLVSYGIGAALYKAPKGWRIMLVLGAAPAIYQAIAIHMLPESPRYLLARNRSEEAYNALARMYPRATQEEMALKFDILTANVDESVRMSNEHTTWELIKMLFTLPRNQRSIFLTMCLQATQQLCGFNGLMYFAPTLFGMLGFENPATGGMVVAGANFVFTATGMLVVDKVGRRPLLAYVSCPGTILGCVWSIVSLYYLTKDTGFQLVDGAAYDPGKQIAVVIGFVCYIAMFAIGLGHVPWTSTDLFSLEVRGIGTGIGTATVWATNLIISESYLSMQKGMTPSGTFGLFAGFVLCGWSYIVTCYPETAGLQLEEVQEVLKDGYNVRKSVKLRKANRKALKASKMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD85</accession>
    <name>I4YD85_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_45712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958219.1">
        <property type="nucleotide sequence ID" value="XM_006958157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD85"/>
    <dbReference type="FunCoup" id="I4YD85">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD85"/>
    <dbReference type="GeneID" id="18472367"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45712"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="I4YD85"/>
    <dbReference type="OMA" id="DSNYMFG"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697866" evidence="8">
        <location>
            <begin position="17"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="175"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="487" mass="52061" checksum="C81F39D870B7F85C" modified="2012-09-05" version="1">MIKALALLTLSASTLATPLYTQELAPIHGEPHVEGSTDPRVHNSYIVVLKDGVEADSHHTFTRNTLKKRSGGGRFGHVYNLDNEGDSIFNGYSVHDVDEDVIDMIRARPEVAHIERDSIVTTQETYHGLDDVVDALDVDDTITQKNAPWGLARISHHDPLSLSTFNKYVYDPHGGEGVNVYVVDTGINTKHVEFEGRAFWGKTIPLNDVDEDGNGHGSHCAGTIASRKYGVAKKAHVYAVKVLGSNGSGTMSDVVSGVLWAAEDAKRKQKAAAEELRTTGKTSHKGSVANMSLGGGKSPSLDRAVNKAVESGLSFAVAAGNDDRDACDYSPASAEKAVTVGASTLWDERAYFSNVGECVDIFAPGLNILSTWNSGPHSINTISGTSMASPHTAGALAYLLSLHSHESHKSFAENFYNTALNTVFETIGGVLPGWIDLFKPSAPVPAPEPISPAFLKQSLLSLAGRGYLNDLEQGSPNLLLFNNATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDI1</accession>
    <name>I4YDI1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_68507</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957831.1">
        <property type="nucleotide sequence ID" value="XM_006957769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDI1"/>
    <dbReference type="GeneID" id="18475413"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68507"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009442_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDI1"/>
    <dbReference type="OMA" id="WIFREYA"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697710" description="ferric-chelate reductase (NADPH)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="411"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="685"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="952" mass="106057" checksum="4A22BC7F51E289DD" modified="2012-09-05" version="1">MKRTLLTLLAYSALAKAQQHGEEHGGEHGGHHHSPQIFYGYLLIIIFGIIACGIALVTHTGLTHKSGIYNKFTRWSLHTPTFQYKLTKNSTHRRYLTLPSIAHMVGIFTLVIFPTMLVLTGPESPSTNRSTSDINQELHRNAFDRTGVIAFVLTPLLVILGLKVPPFAIFAFKWFTNLHFDKALFFHFITGFTVWAFSFAHTVLWIQHAWPRRDESGVWNQIWSSKMNSSGFMALLFLSLILLLSIPPIRTKFYALFHIVHICLVFAFLVAAGVHYKPLAPFIWVSLAFWLAERTWRGLIVLWRNAGAGKFHLADRKPNHWATVLRPAATIKSLVSPQMDKPANLTLMGWEELEKGRNNNTSMHGKSNTTLNKTTSGSNSNESTDKYVPPVVKHETPWMDPPSSSCSFPIRRSHPTGFVHAQLLPGKSVRLTLRLSTPMHWKPGQHASLIIPEISRFGAHPFTIANVDEDDPCKVVFIIRAKSGWTKRLWEKVRLMRQPKFISSEVNPQDSSNYLPCAAPPVYIRALIDGPYGSAERVKWSNYSSILLVCGGSGISFGVSILQHVCNTISLGSGPLRRVRLVWLVKEFAHVQWVASALRRCVTLLSSDAFQLEIFVTSEVKPGDYDPPTISSFFPSPRSPFPPTPATRTYSPPHSPVQRFYTPATGLGDDLVLSYSNLTMQTARASMTPATAAEPQPEQTEQTEQTAQLQPPPLAVTSTSSRIQPSFQSAQTQPEVDKSLPVQPSYEDSEFDTATSKQDDDNNDDDDDIEAINKRSSVNQFIEFDGEDDGPAPPVEKELSTLISVEGEAARAKSGMGLTSSNMQHAQTALSHLEKPKHTPNITFAETPKIQQDANHINGRTPHLTNTPLLKMPDPDNIVIDAIEEGDLFSIAEFARNGRPKLDHIFNQEADIADDNALLVATCGPEALNRTMKNLVSKSNKKTVAFEESFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEB0</accession>
    <name>I4YEB0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_32007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957559.1">
        <property type="nucleotide sequence ID" value="XM_006957497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEB0"/>
    <dbReference type="STRING" id="671144.I4YEB0"/>
    <dbReference type="GeneID" id="18471406"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32007"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544236_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEB0"/>
    <dbReference type="OMA" id="CILVIRT"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="134"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="501" mass="54939" checksum="F34BAB470043A298" modified="2012-09-05" version="1">MRWSNVAAQKSLQISDYAGSYVNAGAAKLGTERFWPTSGDMPLEIDKAERIIRAFTTEGIAIDEPVGEEGKQGRRRVFRKIAPNVLAGAKGIAVFTAMRSGIMPFSGSGGSGIVIARLPDGSWSAPSCICPNNTSVGMMFGLDVYDVVLVLRSQKAVDGFKGMANLTLGAEIGIAAGPVGAGASVESGIDKTPIWSYVRSKGFYVGSELIGQVFIDRFDENERFYYWPGLKSGQILAGKVRPPLEGAQLYRTLHEAETGIAQGQSLEYEATIPDDVLTDLDLNENETLRLPPTPEQLDKFEKQGYKDEHDVEFERREREEIMALPAPPRHPAIVNFLARKEMGLGLTDVNEEEDEEEKEEGAEKEVFDADDAISKEDLLLKLREEELNAELEALEVASEPDMSTEANRNDVGMPPPLPPRRHFNRPQLPSRAARSSLPVISNSESMTAPESPPPNYKSVEPNEDVKKTLALDVEKAGQKTSEESPKEEFFDVADNELGVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEG1</accession>
    <name>I4YEG1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_37140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957608.1">
        <property type="nucleotide sequence ID" value="XM_006957546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEG1"/>
    <dbReference type="STRING" id="671144.I4YEG1"/>
    <dbReference type="GeneID" id="18471998"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37140"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013649_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEG1"/>
    <dbReference type="OMA" id="CDFPVRP"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="267"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="518" mass="59136" checksum="7ED902C47EC3DAC5" modified="2012-09-05" version="1">MSKKELESNENIQFKRWLKYTDELLDNTQQTYFSVYERNLEVWRQFWRTCEMSSILLILIDVRLPSIHFTNSLKSYLNILINKQNKRIIYVFTKVDLVPKQTTDFWFNWLKSQLNDTDQIVKLSSYQIVTGEQGKGRRKPFIQPESLTELLVAISNAYHSLKSSSESLPDINFDEVIQQILLSQKLQRQEESADHNDNKPDSIHTGKADKRKARKLGRIQAESNKGGPKRRGFDDTVNNNNESENEDGGTSQEKRPLEFSNDQNELTIGLIGQPNVGKSSVINGLFGKSKVRASSTPGKTKHFQTLYLTDQIRLADCPGLIWPSTTPRWAQVLGSTVPISQERQPSGILYAIGQRMPLEHVLPLAPESVLETDIKEDKRTWREGMVRTEKSLDKNIKVLEILERYAIRAGFMTAKAGRPDINRASNYILRQITTSQYSWAYLPPGTELNENPNGIYISSKVIYSSDTDQESAIEESENEKSDLDETLAEDSPDEADTTKSMRTAFDLLNVDLVESEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEL2</accession>
    <name>I4YEL2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_28155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957651.1">
        <property type="nucleotide sequence ID" value="XM_006957589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEL2"/>
    <dbReference type="FunCoup" id="I4YEL2">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEL2"/>
    <dbReference type="GeneID" id="18471027"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28155"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEL2"/>
    <dbReference type="OMA" id="MIMGWMM"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="457" mass="50027" checksum="FD7D70F62D4351C4" modified="2012-09-05" version="1">MKRYTHTIAHTLQAPPAEPEFEQALHEVESTLAPLFEKQPEYKRALRVIQVPERVIQFRVPWENDNGEVEVNVGYRVQFNSALGPYKGGLRLHESVNLSILKFLGFEQIFKNALTGLSDELGGGKGGSTFSSKGRSDNEIRRFCVSFMTELSKHIGQDTDIPAGDIGTTGREVGFMFGQYKRLRNEFSGILTGKGLSWGGSLIRPEATGYGVVYYVVEMLKHFNETVKGKRTLVSGSGNVAQYAALKVIELGGSVHSLSDSKGSVIAADGFTPEDIFEIQDLKAKFGYLADWVKTKGDKYVYHAGARPWTLLEKVDIALPSATQNEVSGEEAKALLKAGCRIVAEGSNMGSTQEAIDVYESTLTSEKPLWYGPGKAANSGGVAVSGLEMAQNSQRLRWTAQDVDQRLEQIMKDCYANCFEVGQKYGSGKGYPSLVTGANIAGFLKVADAMKSHGDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YET4</accession>
    <name>I4YET4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_37318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957716.1">
        <property type="nucleotide sequence ID" value="XM_006957654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YET4"/>
    <dbReference type="FunCoup" id="I4YET4">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YET4"/>
    <dbReference type="GeneID" id="18472007"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37318"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_1_0_1"/>
    <dbReference type="InParanoid" id="I4YET4"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="115" mass="13168" checksum="E237B98611F1D6EC" modified="2012-09-05" version="1">MSNQKQKSNQEISIEFNGRRNELQSVAQKIGELEQDAEEHLLVVQTLEEAKKVDPNRKCFRMIGGTLAERTVDEVLPALTTNLTGIKQALSQLIEAYKTKEKEFIDFQQEYNIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV9</accession>
    <name>I4YEV9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957175.1">
        <property type="nucleotide sequence ID" value="XM_006957113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV9"/>
    <dbReference type="GeneID" id="18474813"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63143"/>
    <dbReference type="HOGENOM" id="CLU_1295303_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEV9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="213" mass="23183" checksum="E68263089E9B818A" modified="2012-09-05" version="1">MSISIPLETFFKFELLVSINVSQELNFELVPILTQNDTKNVNPSAVSGDCSTKNIELRSLDFPDRRVIKINLNDSLNGKKSSSTTSPLFEAKDTTMDFNVSTQPHQSMSTGDHSNNLAQNILNVNSTTANEAAGENLFSNLGLDSSIDFSKILQDYLDGSGFKEQTTTELDTALNDFAGDQNVLTPPKSPEFPMIEAGKADLGPVQSVDAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEZ1</accession>
    <name>I4YEZ1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_16850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957172.1">
        <property type="nucleotide sequence ID" value="XM_006957110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEZ1"/>
    <dbReference type="FunCoup" id="I4YEZ1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEZ1"/>
    <dbReference type="GeneID" id="18470707"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16850"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_2_1"/>
    <dbReference type="InParanoid" id="I4YEZ1"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="15882" checksum="2007DF2EB062FBC9" modified="2012-09-05" version="1">MSFPIVHSLWILNKAGGLVYLRSFSDQLPGLNTNEQLVLAGTLHGVHAICSRISPITTSKSSGMQLLESDSFDLTVFLTRTGTKFVLITTPGHPASQALLNRVYEIYADTVMKNPFHIPEMPIRNEMFDTALDGFLRPPDFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEZ4</accession>
    <name>I4YEZ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_56749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957206.1">
        <property type="nucleotide sequence ID" value="XM_006957144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEZ4"/>
    <dbReference type="GeneID" id="18472847"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56749"/>
    <dbReference type="eggNOG" id="ENOG502SBC8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325465_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEZ4"/>
    <dbReference type="OMA" id="KSHINAY"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="534"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="886" mass="97818" checksum="C800DF08F74E0FB2" modified="2012-09-05" version="1">MTNSATVQQLIFKKPSQKYSSQGFERRYQWSRQKTSNLDSNGGSNISNESHGTSIASRRRPLSYYSELPYNQPVSMGRVDPAGTVNTADDVSDTADKDDLTEVEEASESSTIGDQGDHDDRETINGDKQAGDSDSTFRNIQLDEDILNAITTDDHDDDDDQTSLKHTTSIGDLKSVHDTQSIASTTDQSFVSAKESLETASSAISFHSTASNVQFPSEDGHRKESITSSSLHSHTSDDELEAKNAANALPVFNVDSNDAHNSVDQDDIADISADTSPANTTVDSIFDNTHVSFNDSPSTEFNSVVSTVSPKVPPARKRNISAQSETPTIRASSAKNLPPVPPKRERRRVASTPTTNVDESTKRQSNEAIPDRPSSRLILPSEFIKLRNGSASSSVMSESTKYPKSTATSTSIRPSSSMTSRPRSWTVSGVVQSRRTSQVMKPTTFIDQMLPSNALGLERTMLSVSVTSGAADKLAKSSNRSVFSSKSNKRWQKRRSLSWSAGRSNRNYTTMQFSKPMITLGLSSHSKPPEKLDPHFVLIRVHSTALDNFDALTLMRGTGINNFALEEPPGPEYGFIPGRMVLGQVVEVGLKVKNLHRQEWVWSLLSTEKSGCLSEYVVVNRNRVAGTPAYKPSLDLSRLATIPLKAFAAQTLSNSHMNQLKRGSRILVLTANSNPYNSISTYIIEELKLRKCQIFVQTTSYDDFDYGANVYELHGGVLDVVSDQLEGSFEMVIDARLCWNESDNLATLDCCRRILCRDGAFITLIPEKMDVEPTTHIKQSKWKTLLGIFSLRFRKQTKRIQKVILDVAGDEDVDQASGMDIRDRLEEIAYKINTGVYSTFLKDQSASNSFEVENATTAFHTLGFNEKGTNITGQPMSDTAIVRMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF05</accession>
    <name>I4YF05_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_68015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957217.1">
        <property type="nucleotide sequence ID" value="XM_006957155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF05"/>
    <dbReference type="STRING" id="671144.I4YF05"/>
    <dbReference type="GeneID" id="18475330"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68015"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_7_2_1"/>
    <dbReference type="InParanoid" id="I4YF05"/>
    <dbReference type="OMA" id="VFLAWQY"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="96"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="27020" checksum="622C513A62E39D8B" modified="2012-09-05" version="1">MLLSRFSRANINLRKPTIQTRSLRNTYFKSGNRGWQGFYRRGVDPNNLFLGIIGANVAVYGVFVFSDAQWKRFNDPKWMRFMLKNFTASWYNISSGRIWTLVTSSFLHTRLDSLIFNMLTFYFMAPQAIAMLGARTFLMLYCGGGLAASAVTLSNPSNGASGAVGSTLGFFAASFPNATFSLYFLLPVQAWMAVGGLVAWDAYNSFNSPYSANAHKSRLSGTVAGVAFAMLRMRGIGPRIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF72</accession>
    <name>I4YF72_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_36632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957280.1">
        <property type="nucleotide sequence ID" value="XM_006957218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF72"/>
    <dbReference type="STRING" id="671144.I4YF72"/>
    <dbReference type="GeneID" id="18471970"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36632"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_1"/>
    <dbReference type="InParanoid" id="I4YF72"/>
    <dbReference type="OMA" id="PQCGSPF"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698079" description="Glycoside hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="5">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66982" checksum="D5EEA7724BB3A81A" modified="2012-09-05" version="1">MKYAAVVISTLLAAVAAQQPYTVQGPPLKTRWTDQVGTNPWPSHPRPQMFRQDWQTLNGLWQFSPTDAQGLDSPPTGQNLERQILVPSCIESGLSGIQEDQEFSWWKTSFQAPNDWPAGKTLINFGAVDYEATVFVNGQNAGFHRGGYTRFSVDITDHIKDENEILVHVHDPSDTEGINIPLGKQRRYRRSHIFYQPCSGIWQSAWIERVPTDYITDVLFDAQADGSITATITGSDGSSGDVTVSIRQQGSSDEVAKLTGPINTAIKGNVDNVEVWAPGAPKLYDIVVNFKDDNVQSYAGFRTVGKAEINGILRPTVNGKWYFPFSTLDQGYWPDGIYTPPTKEAMQFDVDYLKEIGFNTIRKHIKVEPDEYYAYTDQQGIMVWQDMPSMPHDTTPNDDQTAEYDRQSLELIKTHAFFPSIITWVLYNEGWGQQDGPIEEGITNQVRDADSTRNIDSVSGWNDHGFGDYKDVHTYSDSQCGLIDDEARIQVQGEFGGVGLNMSADQLWPDPAAIATIPETYEIAVDTASYNNRSIEVIDNLTNQVRNNKCSAGVYTQTTDTEGEINGLISYSRDVSKANIDAWKAALQRLYDAAREKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF84</accession>
    <name>I4YF84_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31834</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957292.1">
        <property type="nucleotide sequence ID" value="XM_006957230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF84"/>
    <dbReference type="STRING" id="671144.I4YF84"/>
    <dbReference type="GeneID" id="18471376"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31834"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="InParanoid" id="I4YF84"/>
    <dbReference type="OMA" id="MAKNYPV"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="176"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="370" mass="41979" checksum="156B7F67EFE3E717" modified="2012-09-05" version="1">MLKNINRLNKNISRDLYNRSSLIRRQGIKSYSSHSTHSTPNESTVNSKLIFTTGAILTGFGLVYFNNYQGSANQAIAKVEEKLPVDSASRDYQKVYNAIVDVLETEDYDDGSFAPVLLRLAWHASGTYSKYDKANPGGSNKATMRFKAEAKDEANAGLEIGRDLLNNKVKPQFPWISYGDLWTLAGVVGLQEMGGPKVAWRPGRIDGTDEREAITNRLPDGAKDEHHIQNIFNRLGFNDREAVCLIGAHAVGRTHKDRSGFEGPWTFSPISFSNQFYKLLLESDWKEKQWDGPKQYEDQETKSLMMLPTDYALRTSERYRPYVEKYAENEDLFFEDFAKAFAKLIELGVPLKQFEHSPPVFFKTSDEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFA7</accession>
    <name>I4YFA7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_16517</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957162.1">
        <property type="nucleotide sequence ID" value="XM_006957100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFA7"/>
    <dbReference type="FunCoup" id="I4YFA7">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFA7"/>
    <dbReference type="GeneID" id="18470697"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_16517"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_2_1"/>
    <dbReference type="InParanoid" id="I4YFA7"/>
    <dbReference type="OMA" id="QDGNIEC"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="18">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="19">
        <location>
            <begin position="99"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="17">
        <location>
            <begin position="209"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM22649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="646" mass="72586" checksum="A7EE41A1F0E71A10" modified="2012-09-05" version="1">MHPLDPLTRIEIEQATDATKAFVKLEQGLKPQSLQFNTVTLIEPPKQQVLAWLGYEDNAPLITRQAESVVDLPSNISEGKSVKEAHVTKWKCLDKDQQPSLLVEELNQAEKWAKSNPKILEAVKEVGVDPEMLFCDGWCVSIDERFPGRRLQQCLMFARSRPGDSLYAHPLDFVPVFDSHTGELLALDFPPLNAQDGEPAPPSEGLKPIHITQPEGVSYNIEGRVLRWQNWSLHVGFNYRDGLVLNNVTYDDNGTIRPLFYRLSIAEMVVPYGITKFPGHRKHAFDTGEYGIGTLSNSLSLGCDCLGSISYMDADFVKRSGESKTTKSAVCIHEEDAGILHKHTDFRDLKVHVARNRKLIISNICTVANYEYGFYWSFGLDGNIELEVKLTGIVNVTAMGPNEPRNKQIETEVAPRIAAPFHQHLFSLRIDSMIDGQKNQVVQTDIIPDEDVVGGPTNYYGNGFHTEKTIFKNSKDAISDYDATKARTWTIENPNKEHYSSGNQVGYKIMCNNMSTMFAKKGSMLYNRAPFARHGIHVTKYQDNTLYPSGMYVNQCEGGEQFALSDWIAKGDNVQNEDIVTWLTFGANHVVRPEDWPIMPVESVKVHLKPSNFFDRNPALDVPSVKDSKSRLAEEAEATQDCCNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFB1</accession>
    <name>I4YFB1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957318.1">
        <property type="nucleotide sequence ID" value="XM_006957256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFB1"/>
    <dbReference type="FunCoup" id="I4YFB1">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFB1"/>
    <dbReference type="GeneID" id="18475347"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68096"/>
    <dbReference type="eggNOG" id="ENOG502SRHI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="InParanoid" id="I4YFB1"/>
    <dbReference type="OMA" id="EHDKFSV"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="23795" checksum="1A6CF94604A3154B" modified="2012-09-05" version="1">MPLHFLVLGGTGAIGTLFTHKALVEGHRLTLYARNPSKLSDSLRAQEKLDVIEGELSDMVALETAAKCGADAFISCAGPLSGSQGTPITDCYAKLLPLLASNGVHRAIMLCTPSFSQPEDSFSLLWSFGRVFMRLLHFTEFNEMVSVGELVTLRSPADMTWTLFRVGGLTDGAEKNTTATMLGSGKDHVTISRESVAAWLLKEIKDSQWKLKAPYICNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFB3</accession>
    <name>I4YFB3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_59873</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957320.1">
        <property type="nucleotide sequence ID" value="XM_006957258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFB3"/>
    <dbReference type="FunCoup" id="I4YFB3">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFB3"/>
    <dbReference type="GeneID" id="18473599"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59873"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_1_2_1"/>
    <dbReference type="InParanoid" id="I4YFB3"/>
    <dbReference type="OMA" id="EDNEPHT"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="12"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="538"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM22655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="760" mass="82595" checksum="8990B5D9D4D6C34D" modified="2012-09-05" version="1">MVATSKPRTLYEKVFDDHVVTDDNGNNIMFIDRHLVHEVTSPQAFEGLRNAGRKVRRPDCTLATVDHNIPTSKRENFKSISTFIEEQDSRTQCATLEENIKEFGLTYFGMDDSRQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLQSRKSKNMKVCVDGPLGEGVTSKDLVLHVIGIIGTAGGTGCVIEFCGSTIRSLSMEARMSICNMAIEGGARAGMIAPDQITYDYLKSRPLAPKGEEWDKAIKYWSTLQSDPEASYDIEVNIEAKDIPPTVSWGTSPQDVVSITGNVPSPESFPEGPKRQGCERALEYMGLKAGAKMSEIPIDKVFIGSCTNSRIEDLRAVAAVARGRKVASNVKLAMIVPGSGNVKRQAEAEGIDRVLTAAGFDWREAGCSMCLGMNPDQLSPQERCASTSNRNFEGRQGAGGRTHLCSPAMAAAAAITGRLTDVRELAPALPSSTSDSEPALKILDPKDYTTNQSTLKLSEAKPQGPPETDGAPSAVQQATRAAAAAGMTKFTVVKGLAAALDLPNIDTDMIIPKQFLKTIKRTGLGSAAFYGMRYDPQTGKPDPNFVLNQEPWTKASILINVGGNFGCGSSREHAPWALLDQGIRCIISTSFADIFFNNTFKNGMLPVVLPQEDVVKLSQDAKESKEVEVDLENKVVKRYNGESIPFNVDDFRRHCLLNGLDDIGLTLQKEDDIVTFEKRRSETWPWLDGQEYAGRTFNPPKSKSQKMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE3</accession>
    <name>I4YFE3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_36725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957349.1">
        <property type="nucleotide sequence ID" value="XM_006957287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE3"/>
    <dbReference type="FunCoup" id="I4YFE3">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFE3"/>
    <dbReference type="GeneID" id="18471975"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36725"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="InParanoid" id="I4YFE3"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="266"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="575" mass="64815" checksum="19224D194FC811E8" modified="2012-09-05" version="1">MSGQIVYVDELATVEQPSGTPNQPYKSVVDVLTETPDAQLYVLKKPEEGQPPVKAVKERTNIDYVPISGAALKKAKKTVEVNAKNAAKKAQNKERLEKEEAERAEREAKRIEEAKKVVLTLDESLPTPTKVKAYQLEKHRDQRIKISGWVHRLRAQKGMTFIILRDGTGYLQVVLTGKCTETYDALTLSVESTVSIVGTLKAVKEGQQAPGNHELVADYWEVMSKAPSGDEAFNNKVSKDSDPSIQADLRHLVLRGETASNIMKARAAVLKYFREAFDSQHVTEVTPPCMVQTQVEGGATLFKFDYYGTPAFLTQSSQLYLETCLASIGDVYCIQESFRAEKSLTRRHLSEYTHLEAELAFIDFNDLLSHIEEVICMVIDKLLADPKISEIVYKLNPGFVKPSRPFMRLDYKDAIKWLQDNNILKQNEDENGDKIFNADGTPQMSEHQVGDDIAEAAERRMVDTLNVPVFLTGFPRDIKAFYMKKVPGDEGFTEAVDLLMPNVGEIVGGSMRIDDYQELMEAYKHEGIDPAPYYWYTEQRLWGSNQSGGYGLGVERLLAWLLNRFTVRDCSLYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFG7</accession>
    <name>I4YFG7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957370.1">
        <property type="nucleotide sequence ID" value="XM_006957308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFG7"/>
    <dbReference type="FunCoup" id="I4YFG7">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFG7"/>
    <dbReference type="GeneID" id="18473617"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59901"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_3_1"/>
    <dbReference type="InParanoid" id="I4YFG7"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="363" mass="40551" checksum="53FA623A4084C612" modified="2012-09-05" version="1">MNPRVFIDWNIDGEYAGRLVFELYSDKVPKTAENFKALCTGEKGTDEETGNKLTYKDSISHRIIKGFMIQFGDITNHNGTGGLSIYGGKFEDENFDIKHTKRGQLSMANAGPNTNGSQVFVTFCPCPHLDGRHVVFGEISKGKGLLRRLENIQTGENDYPTVDVRIVDSGLVKEGEDDGVPPLSIGEHEDYPEDDEADSENPEVALKIAKYYKDKGADAFKQQNHSVAVNEWEKALRYLDVNPVLPDETKNEIKAEYSQTRVQLYLNVSIAALKLNKPAVAESMATKAIRTPPTKGQDIAKGLYRRALAKSARKNDHSALDDLNHAVKISPQDANINNQIAFIKNKIQQQKQKEKQVYSKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFH0</accession>
    <name>I4YFH0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957373.1">
        <property type="nucleotide sequence ID" value="XM_006957311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFH0"/>
    <dbReference type="FunCoup" id="I4YFH0">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFH0"/>
    <dbReference type="GeneID" id="18475354"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68147"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFH0"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26488" checksum="8118CC986A880B95" modified="2012-09-05" version="1">MADLQLDSIFGRSPSPPPPPPPKYEKYNYNGRELSIRLESFHPLWAHYLWNASRVFCDYLINNKLCKGKTVCELGAGAGLPSLVASLEGAKRAVVTDYPDEPLLNNLRINIKECGIEKTAIVEGFVWGSNIDHLIEANGGDEFDILILSDLVFNHSQHNALLRSCKNLMKKGGKCLVFFSHHRPHKAKEDMEFFEKATEDGWNVKKVVEELVGVMFEEDGGDETVRATVHGYELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFM2</accession>
    <name>I4YFM2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957421.1">
        <property type="nucleotide sequence ID" value="XM_006957359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFM2"/>
    <dbReference type="GeneID" id="18473633"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59930"/>
    <dbReference type="eggNOG" id="ENOG502SCTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068736_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFM2"/>
    <dbReference type="OMA" id="IENTYIT"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31890" checksum="637424C76D1677EA" modified="2012-09-05" version="1" fragment="single">MVDGSVQDLTLALEMTRHQPLHIRDRLNLNMEKWTIENTNIRVWIDPRAIMTVKWIERIFGNPLSSSTHLHAVIVSIDDIAEDPDPSNEFIIFHDTVNESLNIGRRRKREKEKANVARPDDPLPRTIVPAQPKLAPLDRLNVRKSSSELSRLFPTRPSSSRQSSSDKDKLQMKPPEMKRKRSSLVPNTSSISIESRAASPASSDNSVFGTPTNNQTETINKSSIKKQMIATFANYNITRSHPEFNDLWSICNKGVAFALRHKINMDIIERQQIDSIVLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG52</accession>
    <name>I4YG52_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_67828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956989.1">
        <property type="nucleotide sequence ID" value="XM_006956927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG52"/>
    <dbReference type="STRING" id="671144.I4YG52"/>
    <dbReference type="GeneID" id="18475304"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67828"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018875_2_0_1"/>
    <dbReference type="InParanoid" id="I4YG52"/>
    <dbReference type="OMA" id="GGRWDQT"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="28011" checksum="ABFCF4A9F58BCD43" modified="2012-09-05" version="1">MLPPRPSLGYLSNCTKSSTGPNTTSGSKSTSKKLIILDLNGTIINKKSRNTSQRPYLVDFKGFLFRNFSVIVYSSAMYKNVQRYVESAFNVEQQSKLLAVYSRENMQMSSNDFRNKVQTYKDLEMIWRKHKEYDQSNTILIDDSSTKAALQPFNLLLLSTWDDSKDDSMMIATIGILDEIKNFENISNYFMKYQHIKTVDKDADISIPWFENPVVYAFWLEKGRKLIHLDGILDNIAKLSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG67</accession>
    <name>I4YG67_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_27657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957004.1">
        <property type="nucleotide sequence ID" value="XM_006956942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG67"/>
    <dbReference type="FunCoup" id="I4YG67">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG67"/>
    <dbReference type="GeneID" id="18471004"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27657"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="InParanoid" id="I4YG67"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="356" mass="40897" checksum="FE2F7C153606B7A4" modified="2012-09-05" version="1">MSLYVDKYRPKSLDELDYHHDITNRIRSLARSGDFPHLLFYGPSGAGRKTRIMCTLRELFGQGVEKLEQLKIDQRVFLTPSNRKLDVNIVQSNYHIEITPSDVGQYDRIIIQDILKEIAQTQQIDANAKHKFKVVIINEADQLSRDAQAALRRTMEKYMANLRIILCAQTTSKIISPIRSRCLLMRIPAPQPEQMTIVLNHVAKKERFQIPDDVAQQIGKEATGNLRKALLVLEAMRMQSPNFDMDIQIAKPDWQSYTISVAKDITSDPSPEGLLKVRGKVYELITHCIPPTLILKTLLEVILNMVDDSIRADLIYWAAFYEHRMRQGSKQIFHLEAFIAKTMSIHKGFICGFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG86</accession>
    <name>I4YG86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetolactate synthase</fullName>
            <ecNumber evidence="11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_50492</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957019.1">
        <property type="nucleotide sequence ID" value="XM_006956957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG86"/>
    <dbReference type="FunCoup" id="I4YG86">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG86"/>
    <dbReference type="GeneID" id="18472530"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50492"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_3_1"/>
    <dbReference type="InParanoid" id="I4YG86"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="213"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="419"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="599" mass="65216" checksum="0327A245CBFE3330" modified="2012-09-05" version="1">MPWDLDDSFVGMSGGEIFSELMLRHKVKHVFGYPGGAILPVFDAIYNSPNFDFILPRHEQGAGHMAEGYARITGKPGIVLVTSGPGATNTITAMQDALSDGIPMIVFTGQVATSAIGSDAFQEADVIGISRSCTKWNVMIQNVSEIPRRINEAFKIATSGRPGPVLVDLPKDVTAGICKDPIPTRYTQPQALPPLPNPPVLSSADTGPDFNAIEQAAELINIAKRPVIYAGAGILNSEDGPAKLRELSNNGNIPVTTTLQGLGSFDELDPKSLHMLGMHGSAYANLAMQEADLIIALGARFDDRVTGKVDTFAPAARAAALQGRGGIIHFEVMPKNINKVVQANVAVAGDVTQNLGHLLKHIRSKPREEWFDKISTWKEKYPFIFENSNGKELLKPQEVIEELDKQSRGKKDNFIISTGVGQHQMWAAQHYRWTSPRTMVTSGGLGTMGFGLPAAIGAKVAAPNKTVIDIDGDASFSMTAMELQTASQFNIGVKVIVLDNAFQGMVLQWQDLFYDQRYSHTQMINPDFCKLANAMGVHAIKCESLEELPKAMEEFLAYPTDRPVLLHARVVKSEHCYPMVPTGKALHEQTLHPILVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGB8</accession>
    <name>I4YGB8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_43922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957049.1">
        <property type="nucleotide sequence ID" value="XM_006956987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGB8"/>
    <dbReference type="FunCoup" id="I4YGB8">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGB8"/>
    <dbReference type="GeneID" id="18472311"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43922"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010345_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGB8"/>
    <dbReference type="OMA" id="EHVWKVR"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057573">
        <property type="entry name" value="NOL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24419">
        <property type="entry name" value="Cupin_NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NOL9 N-terminal" evidence="11">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="10">
        <location>
            <begin position="281"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="645" mass="71225" checksum="44BF9D0C58568F3E" modified="2012-09-05" version="1">MVGLSAIAKRKLERTRSAEATTSSIQDDVDAEDIAINAFFVDSAIVEEQQDIESRSDTPRKTRKKSKATSSTTKLGDKSGSDSTEDVTQRRKRKQKAQHYDYNCVSNFGTSESTTLFDSESIYLGFDNHASLILAGKFRLQVLKGSLDIFGTTINASEVVHSVYAPTCYPLPTLSAGTDNPTTLEGVPPALAHNNAVVRLSELKDGLETLGNALPDFKNTFEAPYEGSYEGWNAVKGLYPILESTSNVYAYLLPPSWTSAANIARENSFRSAEPYIAIVKGWKNTGKSAFSRLLSNTLKNSHKKVAYLECDIGQSEFMPSGCVSLHLLDEYLLGPAFTHPRIPAKAHFIGDVSPVNDPSNYVDAIKDLIEHYHSHIAHSLSEDGDYTPIPLVINTQGWIKGLGAELLEGILAAAGTYNLVEMSAFVEQPSEEDNERKDDESTIKIDAIATAENPMLNRYHSADYRNLMMSTYFHSKIQENNLSWDFSLPLTHMVPLCVDYCDDLSYVSIIDGEDVALKHTLMALNATVVALVEGGENVDNNGELLRRDDLTTFKQSRVLGYGLIRAIDSNANQLQILTPLDVTLCRRVNVLMKGKVDLPVCSLIDWTDRDIDYANVPYITNEVAVGEGAQKRKVRKDIQRKAANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE6</accession>
    <name>I4YGE6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957075.1">
        <property type="nucleotide sequence ID" value="XM_006957013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE6"/>
    <dbReference type="STRING" id="671144.I4YGE6"/>
    <dbReference type="GeneID" id="18473530"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59746"/>
    <dbReference type="eggNOG" id="ENOG502S653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605809_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGE6"/>
    <dbReference type="OMA" id="RRWIRVN"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51081" checksum="C247D9B9847738AC" modified="2012-09-05" version="1">MLVIDDWIDATNDWKCSGIEGYQRWRSLIKSEMDATEELSKTADADDVLQASNLIAHSSTFKALINPDVSKHPITAVNKYFLLPKVKGQKGKPKSVKVDVVADAGRSWIRLSSLKMFSILAELAEMDSLLTSSEDEHLLYDHAFTTPMLLKLGHELSEASLRHYIHDQRPDIHLYFTRLTEEEIKHSDPRISAQIEALVSYGINVHYGIPDYTLETGPCKPKEPLRPTSNINLDVSILIAFISLTTHIEDPATASLKPDPSNEHIRAISNQLQQESGLCPLIDLIKKRCDGQQLQFWTTEENKDRTFNILEKIGGESEKRRLESLFEDGQGLFWVGSRHCEQPITGFPVKVIRGSCDHVVKATFDDFVLRRAKKALDLDDYAGSASKLTPHTLRTVIAGLERGWTTLTSNRQSIRALVQGWHTHVNSDDSKATFWLVEPRSLSEQMLERSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGK7</accession>
    <name>I4YGK7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957132.1">
        <property type="nucleotide sequence ID" value="XM_006957070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGK7"/>
    <dbReference type="STRING" id="671144.I4YGK7"/>
    <dbReference type="GeneID" id="18473552"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59776"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_4_3_1"/>
    <dbReference type="InParanoid" id="I4YGK7"/>
    <dbReference type="OMA" id="WLRLMCC"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="187"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="392" mass="44435" checksum="F2E558E309A4FADA" modified="2012-09-05" version="1">MPTTTRSLRYKISSKSLKHKSSNGRISKPKTTQPRKKLTISLTTQNNPLKESEYFEDICYYMHLMELQTLGDLSLIDSQPELDWRMRSYLIDFLIEVHAHARLRPETLYLAVNIIDRYVSRRVVLKKHYQLVGCAALWIAAKFEDAKHAIPCLSDLVVSCCGIYDESAFVQMESHILTTLGWVLGHPTAESWLRIFTLAMGTDDMQTQHIARCVMELSLYRREFIDIPSSSIAAGSLLLARTIVGRARKIVDEDQQSIQVAELLDSFLGEHLDQLSEIISAKYAPHYYSRASIIVREWYLAGKRFYFYAPVLSPSYVHNTPPPTPPFSQSSMETGMYSPGSSSSEDDAPLTPYSQAAPIPSLNVDYKENKQIIKPRPSIQSFTSLQISNKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGW2</accession>
    <name>I4YGW2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_59489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956597.1">
        <property type="nucleotide sequence ID" value="XM_006956535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGW2"/>
    <dbReference type="FunCoup" id="I4YGW2">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="GeneID" id="18473384"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59489"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="InParanoid" id="I4YGW2"/>
    <dbReference type="OMA" id="IVNPFWV"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="81"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="187"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="276" mass="31198" checksum="F2DC5B1336FE09DA" modified="2012-09-05" version="1">MQPFDILKVRFQVATRSERVGYGRAIYSALKNVVKKEGPSGLWRGIVPNIIGNSSGWATYFYFYTTFKDVVHSQQRNNASITPSQYLLCASTAGSISAMVTNPFYVIKTRMYTSSYKNNDAYRGLFDGLSKIVRSEGVLGLWKGTLLALGTVVNSALQFTIYEEMKKTRFAVRGSQPCANDKLPNWEYTALSGSSKLLALATTYPYQVVRSRLQNSTEFENIRHCVKESYKREGIKAFYRGLGINAIRILPGTCVTFVIYENLIWIIKEASFRKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH73</accession>
    <name>I4YH73_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956701.1">
        <property type="nucleotide sequence ID" value="XM_006956639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH73"/>
    <dbReference type="STRING" id="671144.I4YH73"/>
    <dbReference type="GeneID" id="18471302"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31439"/>
    <dbReference type="eggNOG" id="ENOG502S9P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_6_0_1"/>
    <dbReference type="InParanoid" id="I4YH73"/>
    <dbReference type="OMA" id="PSCESNH"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698009" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="119" mass="12130" checksum="E987500F2251EBFF" modified="2012-09-05" version="1">MMFTQIATVVAIAAGAAATPVVRQNSGQATYYQASGGTGSCGQQLSDSQMGVAVSSNMGCTSMCGKNVEITSNGNTVSAPVVDCCPSCEENHIDLLPKVFESLGISQSEGVAQVSFTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHB1</accession>
    <name>I4YHB1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_7884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956490.1">
        <property type="nucleotide sequence ID" value="XM_006956428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHB1"/>
    <dbReference type="STRING" id="671144.I4YHB1"/>
    <dbReference type="GeneID" id="18475830"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7884"/>
    <dbReference type="eggNOG" id="ENOG502S0AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142995_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHB1"/>
    <dbReference type="OMA" id="HWANSPE"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="11871" checksum="0B3C85B21BE60DFA" modified="2012-09-05" version="1" fragment="single">TESIELPDINSEYSDSEDETPKNYELPRWAESPNLKAQLQMQSTINPDEVFGMMRPLSMDDIFGVGQATNPNRHKFRARTSSANWSGADKLTPAEELAYAERMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC4</accession>
    <name>I4YHC4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_67632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956747.1">
        <property type="nucleotide sequence ID" value="XM_006956685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC4"/>
    <dbReference type="FunCoup" id="I4YHC4">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHC4"/>
    <dbReference type="GeneID" id="18475273"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67632"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="InParanoid" id="I4YHC4"/>
    <dbReference type="OMA" id="PNHIRIE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="342" mass="38169" checksum="F23E704119535CA3" modified="2012-09-05" version="1">MSLKTIFSGIQPTGIPHIGNYFGALKNWKKLQDNEANTTRLIYSIVGYHAITIPQSPSKLKQERREMMAALLAIGLSPDRSIIFHQDQVAQHTELAWIFNCFTSVNKLQRMTTWKSKIATLKNSNDASEIDDSALNLGLLSYPVLQAADILLYKATHVPVGDDQQQHLELSRDIADQYNRTYKARRFFPLPNHIITPASRISNLRDPLSKMSKSHPLPNSRIMITDTDKEISSKIKSAVTDSSSGITFDPVNRPGVANLLTILAECTDDTPEEAAVGLSTSAQLKDAVSEATIKTLTPIRDNFYRLSKEHEYLDNVARQGKERASVIANDTMNQVRKHVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHE8</accession>
    <name>I4YHE8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">54S ribosomal protein L31, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956770.1">
        <property type="nucleotide sequence ID" value="XM_006956708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHE8"/>
    <dbReference type="FunCoup" id="I4YHE8">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="GeneID" id="18474787"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62755"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHE8"/>
    <dbReference type="OMA" id="HLVPKWT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11624" checksum="63BC35D57E53038E" modified="2012-09-05" version="1">MFSSSVNLGGLVRKVPWRLSSTRKFRVRERLRDVDQNIQAIKDSGVQFKRLDVASALPSESAMPPRDKYFTFNKNSPTYRKGVHKVPKWTKITQRTNPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHV8</accession>
    <name>I4YHV8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956226.1">
        <property type="nucleotide sequence ID" value="XM_006956164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHV8"/>
    <dbReference type="GeneID" id="18473255"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59259"/>
    <dbReference type="HOGENOM" id="CLU_1195669_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHV8"/>
    <dbReference type="OMA" id="MSSAGHK"/>
    <dbReference type="OrthoDB" id="3365317at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="232" mass="26653" checksum="B56836FC86BFE0A1" modified="2012-09-05" version="1" fragment="single">MAAKHKTFDDSEAAPTNAEIDAFTPAIKPELQYEDSESSDDDDDQPVEAVSTKLSSIDHLRLSREHEERRKTEQRKLKNQRQTLRKQLKEEKRRRDDAIEASTSLATQQSDESSDEELPDRLPTDILEEAARYVPKSQRKDEEEVSQPRKKSRKSRKEQIIGNKLIKLTQSSISTNRADGLLGDGTGKTLKKYNKDMLNRKRRDIRKPAHITHAKSRSGFRPALQFAKSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI17</accession>
    <name>I4YI17_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_27096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956280.1">
        <property type="nucleotide sequence ID" value="XM_006956218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI17"/>
    <dbReference type="STRING" id="671144.I4YI17"/>
    <dbReference type="GeneID" id="18470977"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27096"/>
    <dbReference type="HOGENOM" id="CLU_586903_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI17"/>
    <dbReference type="OMA" id="ANLANEW"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="466" mass="53667" checksum="B2488E051F5D68E2" modified="2012-09-05" version="1">MENHDKDYKDDDTASISSEISDHPYNRPEERPKSKTKIPRPPKSESIEEMKNTAGTDMSKLNQTELSKMIGIKWRSENIQVKHIYQEKANEARREHMLKYPKYKFRPNRKHDRIAKIGTRTTQITKTAQKTQKNHKNLKTKTPLKQLCSSDGEGEGDDDDYDYKCSQRAERQLRRNVKVRGERRKRCKQEEEVRTVDIMRKSHHHKGSDDRYIRPGSPLLSLPDPTFTLPMEVENDMTNISTNLVHDSDLGIYDSNALVNQSDNRISFDDFAYDPEVMFAPETATNLANEWANNNYVLGTDVGVDNVIGVDNYHYINDIFGNIPTTNDIAPLPPPPSAFKYMNDMMDISSVDLGTIYQDDRVGISSSCSSSSTVSTTSTTHSLDSYDNCLPDFLNVDITEGLNDTHIGERARSLIADYYLYEEREEQQQQLQFQQEHQDIPTQQDIFKTFQRQLAETRTRVSQNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI43</accession>
    <name>I4YI43_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956304.1">
        <property type="nucleotide sequence ID" value="XM_006956242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI43"/>
    <dbReference type="STRING" id="671144.I4YI43"/>
    <dbReference type="GeneID" id="18473281"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59303"/>
    <dbReference type="eggNOG" id="ENOG502RZR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013668_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI43"/>
    <dbReference type="OMA" id="NHAWYEA"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="96530" checksum="8B4533CCFE251D7F" modified="2012-09-05" version="1">MPIPLPLLPLIAETIYYSSRPSIDLDPVPEPGSWSEQDARHTLHALSRVNRDWHDEAGKYLWRRLHFRLAGGFLSVVDVVAGKQDEQVRQQSNHFRSLSKPPAIEPLRPEAILPDGPTLPRNTYRTTSLRIASIPEASESAPEETPKDTSKSAFSPPSFSNDFTTPLQSPESSSPPVSSPLALPSISSTFFSHPIPNDETPPSSRKQSPSRGRARRQFQDPSARSSPFRARSMSPPRDLSEIVNLATQLQREEVEIKRTNSPETRGRKFDRVRELSKEAERLRSASPITAKLEECHYDAITVREPSPERERLAEMREQSPDGQENELWSSSGTWLDPFCPVTATPYPARHINHISFTSFRTAGLRRSIAQGTEERFCTPERLERLLDACRAVRGFGASEYMDSALSLPVLESLLLREPPAPQTHKTRLRRAFSVRDPPTQQAHEEHEVQNRAKIIPGRPLHALDLSGCVSQMFFDSLEAFVNKHLFAKQSDAFDELDDLLRYDDEVRAQSMERKADTSSTDKPSNPHTGRFSALRRLNVSNLVNVFSPTLKTFVLAFPTLTHLDLSNTRATPGLICALARSPTVRLESFAAARCKKLDGESLVRLLVESPVTENLKELNLYGDSAVPSPFHADELEILLRCAPCFVSGNMRYIDIAGAPLTEKMLQNLSAQPHLRSLGLANIPRIPLSAVADFIKNKAPGCEIVDLALSTPELAVIPGVSSTVRSAVLTFQNKFIKVLTNPPFRFSLTSPTPVEESPPPTAVRVVELGSEMLNALQGGAGNWRVIRSRGRRGWYVDVSTKPLQDGLLARNLDKGDKWRQQMEYLSQAKGNVASYIGWHSRKMEVLSGQGMLGREDGLYGVYAYSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI56</accession>
    <name>I4YI56_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_42833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956316.1">
        <property type="nucleotide sequence ID" value="XM_006956254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI56"/>
    <dbReference type="FunCoup" id="I4YI56">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI56"/>
    <dbReference type="GeneID" id="18472267"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42833"/>
    <dbReference type="eggNOG" id="KOG3341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070147_0_1_1"/>
    <dbReference type="InParanoid" id="I4YI56"/>
    <dbReference type="OMA" id="QIVEVCM"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="249" mass="28353" checksum="24C9924A94E066AF" modified="2012-09-05" version="1">MSRRYNKGIGSLQHHHNATAYQNLSNTINDNQLQAVKQQLDVFKDYLKEFSIKHRKDIESNVEFRNRFTQMCATIGVDPLNIARGSLFSNLTGISDFYLSLAVQLVDMCISTTTLTGGLVRLSDILKALSIKRNTEITLSDIQKAIKILQPLHDNQHLYEIIPINQILYLRSQPKELNNDQMLLLTSASTNNGWVDQSLLQSNGWSIDRARNSLRQAVMDDGIVWIDNQEPQIKYYFPALFQGVVNTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI58</accession>
    <name>I4YI58_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956318.1">
        <property type="nucleotide sequence ID" value="XM_006956256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI58"/>
    <dbReference type="STRING" id="671144.I4YI58"/>
    <dbReference type="GeneID" id="18475231"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67281"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210610_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI58"/>
    <dbReference type="OMA" id="FDFWDNP"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF14">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="229" mass="25502" checksum="CA1CDB8567F8ED05" modified="2012-09-05" version="1">MSDPYKVLELPNTATEKDIRKQYLRLARIYHPDKVEDPQKAQAEEKFREISVAYETLTQPADSTSRAGYSRSSAYSDPFSLFDELVSQMRSSTAFFNDPFFNDPFFNRQPSMHRSDPFAGFMGGDMMGFPSMMGGMGGLSSMGGFSGMSSMSSMSGMPAMTSGRSISTSIVNGRKEVKETTRNPDGSTHIKITTPEGVHESTQQAQLPQANHHSRSNYHALPSSYNRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI86</accession>
    <name>I4YI86_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956344.1">
        <property type="nucleotide sequence ID" value="XM_006956282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI86"/>
    <dbReference type="GeneID" id="18475237"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67306"/>
    <dbReference type="HOGENOM" id="CLU_886240_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI86"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36232" checksum="69865BBE7F1DC1D7" modified="2012-09-05" version="1">MSESEFKLGVDSNSKILNEDGDPVIEIVEDVKDTSKKIKTGITEPLDSDRMEKNVTRRRVSKLRELLGVDLDHESLPNESKKTKSVRFNKKDLEPTSNSSKRSNQGVLNDLVVERSNDSRPDRLSTSEDELDFYEDDEDTLDIEADLMQQQLAVAYHTKRNNFSDLQDDIWDQEFVPDDASLVGQAPPKGKFEPYAKRSFSDKMINENGDEEQVSIMIPRLVPGMKMGHYNDGVITTEEADEWDDYTEEAKQLLEKLKMGNREDLPQLQRPMERNVEEMERKPPRVEATTREKDEEVEVKPKISRFKASRMQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-01-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA2</accession>
    <name>I4YIA2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956360.1">
        <property type="nucleotide sequence ID" value="XM_006956298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA2"/>
    <dbReference type="GeneID" id="18474740"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62362"/>
    <dbReference type="HOGENOM" id="CLU_2039878_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIA2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="121" mass="13562" checksum="0E33ADCD46E253DB" modified="2012-09-05" version="1">MSGDSRGLLEGNTKASKLLNDEYKQVKEFDQEEGWEEIGEDIVIIDSTPNFKESVKESDDFQLIGLDTETPIFRASSAFYKLKPGNSLNTNLIVDQQSSYSTHNVLRATPITVQNKESNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA9</accession>
    <name>I4YIA9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59349</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956367.1">
        <property type="nucleotide sequence ID" value="XM_006956305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA9"/>
    <dbReference type="STRING" id="671144.I4YIA9"/>
    <dbReference type="GeneID" id="18473302"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59349"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015739_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIA9"/>
    <dbReference type="OMA" id="GFHIHDF"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697825" description="Amine oxidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="12">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="293"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="731" mass="83168" checksum="274BFB2373F3E162" modified="2012-09-05" version="1">MKFLGLVLVGVASTAVASFCPAFSHYEEVKSKENPFNQLSSDEFSKAYQVIYDKFNLTSLEDAGPTDNYVEMLTLNPPKKYETLGYLNDDGDKPDRYAKVLIAHGVDSDPTIKTYNVGPLNGDDNDIQVHTTNASPIPFNSRRTKAHKDKMLEKVFIYYALAPIGSIIEDLLGKPWNLEEYMYLDQRANLDGDKRLRWLELSQKPDDSAFWGGFTGFHVLFDFTGQKFSDWKVLKVVYDDKVWRGLEDFKNDYDNGKIAKTLPQFTEKQLAHWTRRRPDVPVRDLENRTTPTSLSKDGLRYRLDEEENYVSWLNWGFFFSHNPETGISIHDLKFNDRRIAYEISLQEAVSHYSSNSPTNANSALLDRGIGLGEKLTPLMKGYDCAEEATYLSTRNWNGTHDVVTPNTVCIFEMPLLQPISRHYGLEDASANKASKLVIRSISTPGNYDYLIDYALFPDGTIEVSAAASGYLLQSHISKGGDDFGTRVSETTAGNVHDHVILFKFDLDILGESNTLVEKSIDVEERKFFWQDDDEEGYESKIIKSRNIEQEKAMNWPYNYDRWLLLSNLDKRTSLGYNPAYRIMPSTSVIHDTPGTQSRMKRNAVFSREHVYVTKYNEDEESASSVYNMILPNDPPVDFSTFLNNEDIVQEDLVLWANVGMHHLPRASDVPTTLFLETKSGIMLSPFNYGDEEFSRDLTNAIYATIDNVTDEITSVKVYNNADNCGIDPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YII5</accession>
    <name>I4YII5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956440.1">
        <property type="nucleotide sequence ID" value="XM_006956378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YII5"/>
    <dbReference type="GeneID" id="18474750"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62446"/>
    <dbReference type="eggNOG" id="ENOG502SG0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1526360_0_0_1"/>
    <dbReference type="InParanoid" id="I4YII5"/>
    <dbReference type="OrthoDB" id="4932133at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045992">
        <property type="entry name" value="DUF5948"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19373">
        <property type="entry name" value="DUF5948"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698045" description="Hydrophobin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18109" checksum="7B250EA536C7B5B9" modified="2012-09-05" version="1">MFKTTVISALLASATLVSAGGPAEICTSKGGTSCTEYQITKDCCAAVDQNTRFDEVFTQCIPLLANGINTGGMVECCESRGAGSAEVKIGADKLVCTGGPAEICTSKGGTSCTEYQITKDCCAAVDQNTRFDEVFTQCIPLLANGINTGGMVECCESRGAGSAEVKIGADKLVCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIP6</accession>
    <name>I4YIP6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_6819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955636.1">
        <property type="nucleotide sequence ID" value="XM_006955574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIP6"/>
    <dbReference type="FunCoup" id="I4YIP6">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIP6"/>
    <dbReference type="GeneID" id="18475361"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_6819"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020823_0_1_1"/>
    <dbReference type="InParanoid" id="I4YIP6"/>
    <dbReference type="OMA" id="TNQRMER"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="269" mass="30560" checksum="BDCC005C8926FBAF" modified="2012-09-05" version="1" fragment="single">RNELFSGAPRSARNYGGGINQSAYEGIDEEGEGGGVANEEEEVEAIKQQTRYVKEDSKDSTRNALRIARETEENATTTMMKLGDQSERIADTERHLDLAKAHSNRAEDKAKELKKLNRSIFRPVITWKTDRRRQEIQQKIEDRHETEREEREKAHADVFASRKRVDEAIDPRKGALRGFGALGRKAPQASSSVERSKYQFEATASDDEIEDEIDSNLDEISQAVGNLKRFAIASGEEVETQNTRLDDIHNKAGRLDDKIFRNTEKLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIR2</accession>
    <name>I4YIR2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955700.1">
        <property type="nucleotide sequence ID" value="XM_006955638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIR2"/>
    <dbReference type="GeneID" id="18473101"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58974"/>
    <dbReference type="HOGENOM" id="CLU_422851_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIR2"/>
    <dbReference type="OMA" id="GPHVIND"/>
    <dbReference type="OrthoDB" id="10684250at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="648" mass="75228" checksum="3080830777ADF7F7" modified="2012-09-05" version="1">MSQSRKRRRPVRVSLYDYEPRTSESSIMKPKRSRKSDPIGYRSTVSSQAPFIPQNRIEDVTNYKTVPDNKTRRTEKDGNSLESLRKRKEEKQKHFEKHTENQQIPPHQQHSDIHQQDQASNKQPSGPSGQQSMTEQKQTKQQQNGENVNQKAGQGAVKKVNGVDQIGKARNNRNINMRERSTDHHSRRVISMSKLDREEEDERKYETNQEDEVRMQHTANNQEVEAAIRQQQFQSTAIKRIETASHMAYHKQIYDSPRMIEDENTLNQTENGSRAYTSRVQDADRIASPKVDQVDVMRLFSTQVEMMNIITKTTTRNEELQQIIRDLLRKDNEKDVKIKDLEISFNEKIEEERRNSAKIAETSAKCYNDLILEFDIIKQDKDTKKGVDESIAKAVHDAKEQVKLQELRNDSFIISTISHLEKVDKNIENLLASNLNEVQRKEKGSEINSSVIGKQDALRDDFKSRLDRHNLEIRRIDQTIVSQNESLKKRVEDLTMREQKREENDKLFRQAIDAFVTSSSRFAQDVEGVKRGMAQVQTQVSDLIYKDNYLNDRLSSIVSKVDNTSSSQSRQNDYLKNQITTHSRELKRLMLERASDADMSLKDVRDKIEFLKGRVIALDKVVNDSLRNITIHPAYEINSIRTVSEDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIS5</accession>
    <name>I4YIS5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_55806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955711.1">
        <property type="nucleotide sequence ID" value="XM_006955649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIS5"/>
    <dbReference type="GeneID" id="18472743"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55806"/>
    <dbReference type="eggNOG" id="ENOG502SUEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_7_0_1"/>
    <dbReference type="InParanoid" id="I4YIS5"/>
    <dbReference type="OMA" id="FCANLHN"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="375" mass="41042" checksum="3991AE1870F16EA0" modified="2012-09-05" version="1">MPQMEVYYNKSESIMSLSFLANSGGYCIATVASSYMIHHMPLYIVLMISTFIYAAGSLIGTFKPPFAALMVSLVMTGVGGGLLDTAATSVLVHFENGPLLSLAFSFFAIGSMSSPFLVGGLRESERPWELYFWFPFALTCFLFVLQWFVYRSYKAPIEAAGIQISASRRLRIICTNPMCILAIILSFLTIGIQGSWSQWASKYLQDTKKLESGVPQLAQGTFWAGVTVSRIVLSYVIPVVGYNLSPLLLLAGYAATSAGMWKLPTENIAGAMCLNVLLGFATGPLMPLIISGLCSGLLGSSILPLVIGQGVDTFNTDIIPGVLIVVLLLIFCINVILHLFKYRDLANQNGNERSLYQFMRITYTFPQRSKDTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIU0</accession>
    <name>I4YIU0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955726.1">
        <property type="nucleotide sequence ID" value="XM_006955664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIU0"/>
    <dbReference type="STRING" id="671144.I4YIU0"/>
    <dbReference type="GeneID" id="18474672"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61713"/>
    <dbReference type="eggNOG" id="ENOG502SE4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1732906_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIU0"/>
    <dbReference type="OMA" id="DDIDCAL"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="151" mass="17430" checksum="E5972AF2D6F9E8AF" modified="2012-09-05" version="1">MLNRARAVLRAPRVASARCHSSINSFDRTLYLKEQPEDSVFKSLENKQNLAFETFVAGHRPLFISNPPLESSNQVSHKLTDEQVDSILDELDCALFKVKITEIADYKSALHRIGLGERLDINLDSVKRKRKSKMNKHKYRKRRKVCTLVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIX4</accession>
    <name>I4YIX4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955757.1">
        <property type="nucleotide sequence ID" value="XM_006955695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIX4"/>
    <dbReference type="GeneID" id="18473120"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59006"/>
    <dbReference type="HOGENOM" id="CLU_1846683_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIX4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="15497" checksum="4DB5FA74B540D691" modified="2012-09-05" version="1">MPVMNMKMTVPLNLKMGSCIQGKEESLTLVYLECFTGNIYGTKYPLLLSHYLYLVTIFLWELAIMGVVGAFPIQLSSGRKGYAILVIGNTTGPQPIESIHHPLKIKSSLCMIMKRSMICGLVSRTYPNPTEKTAFLIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ04</accession>
    <name>I4YJ04_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_34458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955785.1">
        <property type="nucleotide sequence ID" value="XM_006955723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ04"/>
    <dbReference type="FunCoup" id="I4YJ04">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ04"/>
    <dbReference type="GeneID" id="18471864"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34458"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_1"/>
    <dbReference type="InParanoid" id="I4YJ04"/>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="455" mass="50068" checksum="3BAF338EFB4551F8" modified="2012-09-05" version="1">MSEKAELLGFNAKDAFDASQLLETTERSKALLAIKDELIKRKDEVFAANELDLKEAALLVEQGKLSAPSLRRLGLNNDVKFNGIIKSLEEIAELDDPNNKISYAVELDKELELYRVACPIGVLLVIFESRPEVVINVAALSIKSGNAAILKGGKESKNTSFILNNVIQTALAERTQLKPHLIQTINTREEVSSLLHLDKYIDLVVPRGGKALVTSIKENSKIPVMGHADGICSVFVDESADLEKAVRVVVDSKTDYPSVCNATETLLVHQSQLGNFNTIAEALLTNKNPVTMHLDEKSFAALSDSIKQQYSQQLVKSTDEDYETEWLDYEISVKVVDSINEAILHVNTHGSHHTDCIVTENDTNKNTWMKGVDSAGCYVNVSTRFADGFRYGFGAEFGVATGKTHARGPVGLEGLVIYKYILRSIADKGHIVGEFGSGGKSFSHTPIKDDRQPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ47</accession>
    <name>I4YJ47_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_66865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955824.1">
        <property type="nucleotide sequence ID" value="XM_006955762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ47"/>
    <dbReference type="FunCoup" id="I4YJ47">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ47"/>
    <dbReference type="GeneID" id="18475168"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66865"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323935_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ47"/>
    <dbReference type="OMA" id="TRMLCSK"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="576"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="100287" checksum="E109C8B5C213AF44" modified="2012-09-05" version="1">MANDKDFDEMLNSNKTKFITEESRQTLPTITTTDTNKKVSKRRKAPSPIKIPKQERRRSTSIGSAYLDSQSTGADFQSISLERVGIPTSPAFNHAWYSPPAVQEPARKSPLPSPKIPSPMPSPRISSLAFSKEKSLDKLERSNTPTSTHSTVTRKLSNFNLSNDDPTTPVLQQSPSIRLINDNDSQTKNDQNRSLPPLPPSPSHSDLGLKCWNQDESFLPKQKHAEWLGSLGATNKQALYTYMSQFDFCSLRLDDALRKLTSKLFLRAETQQIDRILEAFSIKFFNDNPLPLYRSPDVVHAISYSILLLNTDLHIADIVTHMSRHQFIKNTLNVVHNQYDSRGFSTPDLVDDTSSITSSKTTNTINKNQPQQSIPQGPPLSYYTRKNKLGRNGSLSSIRSGLSPSYSTSTSPSSSSLTEEKVKKSASSMTISTSYESQQLDAELEPFLRDIYNSIRSQKILLPLDGNKANNLSVNTSRQRLPRNMSSPSISTSSLKRGSIRGLSSLLGTDGRTSPTPSLGSVMEAPTPSIGFASNLSQTIIKEQQEDAISNKSALSDNSDAGLILTDEELALMGPPWAKEGFLQRKHYYESDGKRSKDRNWLEVFVVIGRGDLKMFTFGESAGVQGAQSSGGIGGGNWTNNANLVGEIPLAHSVSDYMRNGYNRSRPHCFQLSLPNGGKYYLQAGTESLLDEWVSTCNYWASRASKEPLSGGVSNMEYGWNSVIGEVESGSSMLKPQREEDVMSVRSNYSINRWKQPFRTNADKMYIEDWNAPHLPVVSSTLTEEDQQRALQKFSASLKKDLRVHRQIYDRMLQQYSTKSSNRDKATHNWNKKNKYLITEIKKYDRYIDNLNQAISMRKQKQHEKQLEKALAEPESDEEDEEDDDDDEEEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB8</accession>
    <name>I4YJB8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_8155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955638.1">
        <property type="nucleotide sequence ID" value="XM_006955576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB8"/>
    <dbReference type="STRING" id="671144.I4YJB8"/>
    <dbReference type="GeneID" id="18475836"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_8155"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="I4YJB8"/>
    <dbReference type="OMA" id="NGYPPFC"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="34492" checksum="02AF03AF1936553C" modified="2012-09-05" version="1" fragment="single">SNNEEKEIGEWTFGKEIGKGSFAIVYHGWRTGNNNSCAIKSVIKSKLTAKLLDNLEGEISILKRIHHPNIVGLMDCFKTNTHIHLITSYCSGGDLSCYIKKRGQVPTLEYWPSGIEGVGAPAFYKHPDSGGLDQNVVRSFSGQLAQALLFLRSQDLIHRDIKPQNLLLQPADPADLERGHPLGIPILRVADFGFARNLPAAAMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVMYEMSTGRPPFRAQNHVELLRKIERSEDKIKFPSPTESMQFDIPRDIKDIIRKLLKRHPIERISFEDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC9</accession>
    <name>I4YJC9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955898.1">
        <property type="nucleotide sequence ID" value="XM_006955836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC9"/>
    <dbReference type="STRING" id="671144.I4YJC9"/>
    <dbReference type="GeneID" id="18475181"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66933"/>
    <dbReference type="eggNOG" id="ENOG502S7D8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710186_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJC9"/>
    <dbReference type="OMA" id="LHYNIER"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="390" mass="43796" checksum="B794837651F75142" modified="2012-09-05" version="1">MTIRNISIFTTEFINGEDDARFRKTLINHSSGSPLYVRSLLKDSSEYAFALRDALSDSHLADVITEAGVSAKKKTINLYQPDSEVGLEYTGTLSFEWTTYFEGHTLQWSKGLLGSIYCSLIRKPDPSVEVCKYVPGNKKSPPTFTILDYNLARFELEDIRGLEIVLLCSVFTFLDMQNQEVGPGEPAKDEPMMTSAVPISAAPAGPALPDRKPSLYEHPRSKLQTIDANTLNISPDLDFEGQVRKTLNMLDGNVFVTLHAPESAAVQTAIRVAESAKRRYMKRPGGMRDDEDLHLYVITDDLLKDRRVSKVYVPPSTLTIHISKWHMPELEEKQQQKRKMMEDSADDIESDPIENTTRVSRVVPSPTTPTNPRMSFINSLNKLRRGVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJH9</accession>
    <name>I4YJH9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955947.1">
        <property type="nucleotide sequence ID" value="XM_006955885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJH9"/>
    <dbReference type="FunCoup" id="I4YJH9">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJH9"/>
    <dbReference type="GeneID" id="18473176"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59103"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJH9"/>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="131"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM24121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="559" mass="63064" checksum="C88996BC84F30570" modified="2012-09-05" version="1">MSEPAPKKFKSENIPDVSERFSDNLFNSTSVEEYRNAYKQSEPYKHAVIPELFNKDFLLQARKELLKLSFKEKETDIYKITQSGDFSNIHLLPEEERKELPTLLTLRNTLYSAQFRRFLRDVTGCGPLSGVKTDMSTNNYGSGCHLLNHDDVIGTRRISFILYLPLPDPAWEAHYGGALELYPLSTPLTDPTTPAPKPTVSIPPSFNQFAFFEVQPGHSFHSVEEVAFHPKLQFKTVDGGVGQRVSISGWFHRPVPEEEEYEGPQPELTKSSLEQLYAAALRPLGSYDDDGLKSVVEKLDASEVTELEELVNPVYLDTKTIGLLQNKFLEDSHILLTDFLKEDIATSLKELVKNRDDEDEVTRGKRVLRNDYGTSYKIPAHPTGEAGDWKLVGPPHVQRYVSLTKQDTEGDLFGRVNKLFSSKAFRALLSILTSSVPEAHLIESRRFRPGLDYTLARGEKSSSETSRLDIGLNLTQSDDIWKSGTVGGWDVWLSGEEDSDEATYGAGDDDGPLLSLAPEFNRLHIVLRDPGLLHFVKYVSTRAMNSRWDVTGEWITRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5F3</accession>
    <name>I4Y5F3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_58878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960767.1">
        <property type="nucleotide sequence ID" value="XM_006960705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5F3"/>
    <dbReference type="STRING" id="671144.I4Y5F3"/>
    <dbReference type="GeneID" id="18473083"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58878"/>
    <dbReference type="eggNOG" id="ENOG502QSCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007574_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5F3"/>
    <dbReference type="OMA" id="TWEQMIS"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="736" mass="82140" checksum="B64EE54756385210" modified="2012-09-05" version="1">MASKPQRKRVHFSCYECHRRKQKCNRQQPCDQCVARRIPHLCRQFIDGVHDPYENDVDVKARLDKLTRTVEDLSHLLSSHLNQPIPSTSNEVIPEDQGRLDKGRFFGSSAMSSVSESTFNVPTFNNIVQTPPDPAGAESNIDKVKRLLSTSGITMSDLESVITNLPRKELQDGLLSVYFNEIDWRYPLFSPRFYLSYDSLHEALPSGIYNVTPPMIRFIPLLFITLAIATLTAPDDLVGDANSRKKLHESLYGSSRRSANLAGAMQDDDLDSVLCGLLTARYLILVRRASEGFVPLGAAIHTAQALGLHRDPAALKINDVLDQELRRKVWTYIYHQDRMSSLLLGRPLAINDADCDTKPPSNISDEALNAGKLTIEPMEVPTIMSYTILRHSLAKLMGHIQTAAFGIRPPPYHVILQLDQELIQFKESLPPCFQLDNPDLRHDPYLTYLSTHRYFLSTEFYFVRITLHRPYLILGKSQSTKYQPSRIAAIESAKADLVARKQYQARAVTRPNKLSAGSYRIMTSLMILGIALVLTPTGSEADELRKFLDEHTTGVDEATVRELAVLELFKRGATEVSNNANSKKRRYSEAAVDDTTTNSIRHEPTAEPVKTELDNDPAASLNPSFPLGAQNFPSIVPPPAAVPPQQRGQDTTVASSIPTAEYNRMTEGIHNINNTNNSSNNEMDLLGEHAQALLNQWLDVNSLTTTTPPGVGISEDNANDPEMDFWQNLVTTLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5L0</accession>
    <name>I4Y5L0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960749.1">
        <property type="nucleotide sequence ID" value="XM_006960687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5L0"/>
    <dbReference type="FunCoup" id="I4Y5L0">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5L0"/>
    <dbReference type="GeneID" id="18474622"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61584"/>
    <dbReference type="eggNOG" id="ENOG502S1U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5L0"/>
    <dbReference type="OMA" id="IYHTPGG"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="61"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="232" mass="26482" checksum="C04007009C18041F" modified="2012-09-05" version="1">MFSTINHGNNRQSSHNEQIKALGFIGLGIASAFMGIFAHKTLVRRIKNADMISVSMIERQATIRGVITRVGDADNFRMYHRPLLSLDSRSSILQKKLTAVDTIHVRLAGVDAPETSHFGKPAQPYANEALQWLKQKITGEKVAVKLLRKDRYGRVVGNAQLCAKWYRPWRKNISMELTKAGYGAIYEQDGAEYDGMLDKLRRVEEQARRKKRGMWKQKHVELPSTYKKKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M6</accession>
    <name>I4Y5M6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_22743</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960662.1">
        <property type="nucleotide sequence ID" value="XM_006960600.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y5M6">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5M6"/>
    <dbReference type="GeneID" id="18470932"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22743"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_0_1"/>
    <dbReference type="InParanoid" id="I4Y5M6"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="825"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM19268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1361" mass="150121" checksum="FDFA761C7CB916D3" modified="2012-09-05" version="1">MENKLERWRSHIGGIPALALPTDYPRPSQPKFVEAVEKFGIEETSEQSELIAIYLMLLYRYTGDTSIIVGFNISNEPTFSKFEIEPTASFNSLLDHVKQTISDAEKFAVPFEQLRSEILKGSQSNDSTIFKVSLSTSTNERTQSALSSDLAVHYEKFDNSIKIVYNALLFSNQRVKNFITQFNLIKQNISSISNIGSFSLLTESQQNILPDPRADLDWCGFKGAITDIFSQNAQDDPTRTCIVESTDDGKKQIWNYKEIDGASNILAHHLLKGGIQREEVVMVYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPSRQNIYLQVARPRGLVVLERAGALSSDVKDYITQELDLRVQVPALSLTKDGLKGGSLDGQSDVLANPAPNEVQHPGVVLGPDSVGTLSFTSGSTGIPKGVMGRHYSLTHFFPWMSERFGLSKDEKFTMLSGIAHDPIQRDIFTPLFLGAQLHIPTSEDIGTPGQLAEWMADSEVTVTHLTPAMGQLLSAQASRQIPSLKNAFFVGDVLTKRDCTRLQALAQNVQINNMYGTTETQRAVSYYSIPSVNADVSFLGRQKDIMPAGQGMIDVQLLVVNRQDKNVLCSVGEVGEIYVRSGGLSEGYLDPNATKEKFTENWFGSGVERKDTIASSKEAYGRYWKGIRDRMYRTGDLGRYGPDGLVECTGRADDQIKIRGFRIELGEIDTHLSAHPLVRENVTLVRRDKDEEKVLVSYFVPNQTNDLEGYMSNDEEDDTDVQDERSREIARGLKRYRKLIKDMREHLKTKLPNYSIPSIFIPLTRMPLNPNGKIDKPALPFPDTAILVPRSNVRDDRTLTPTQQTIHDVWKNLLPSAPSSIALDDNFFDLGGHSILATRLIFEIRKALVVEAPLGLVFEQPTIGGLAQSIEALKASDLGLHSDVSGKKEEKAAADEVLYGQDVDNLIPQLAAKYEALPSDFNNKKLTVVLTGATGFLGAFVLRDLLNLRSDRVGKVICIVRAKSSEDGINRLRQGGSARHSWDENWVQSGRVEAVVGDLESNHFGLDDKEWSRLSSESDAIIHNGAFVHWVYSYGKLRSANVLSTLTAIELASNTKSKALSFVSSTSALDTEHYIKLSDELSLSGCSSGVLESDNLEGAREGLGTGYGQSKWVAEKLMMEATRRGLAGSIVRPGYVVGDSESAVTNTDDFLWRLVKGCVQLGQVPNIHNSVNMVPVDHVARLTALSVLYRLETGASTPVVHVTARPPVRYSDLLGCLEKYGYGVATSDYLVWRSELEKHVMEVGDNALFPLLHFVLDDLPTSTKSASLDDRNARKLLESVSGGESVKTTVDMPLLGLYLAWLIKADFLPAPTQKGELKLPEVEEARAIGRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5P4</accession>
    <name>I4Y5P4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_34149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960679.1">
        <property type="nucleotide sequence ID" value="XM_006960617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5P4"/>
    <dbReference type="GeneID" id="18471824"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34149"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="InParanoid" id="I4Y5P4"/>
    <dbReference type="OMA" id="PQRMIDN"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="328" mass="34973" checksum="F806393723157F9A" modified="2012-09-05" version="1">MNVAAGSKLAAAVSNAGGIGVLGGLGYTPKNLQHQIDELKAGLVDKNLPFGVDLLLPKVGEGARKTNYDYTKGQLPELLDVIIKNGAKVFVCAVGVPPKFAVDKLHEAGIPVANMIGHPKHAQKAIDAGVDILIAQGGEGGGHTGDVPTSVLIPTVVEAVQGVKSPLTGKQIQVVASGGIYNSKGLAAALSYGASGVWVGTRFVASAEAAAPKYHKDLVLKSTWDDNIRTLIYTGRPLRVYGHDYVKDWEENRRDEIKELTSKGLVPHEVELEKRPEISAKTRMWLMGKVSGSIDKVETAKEIVDEMVTGAARIIQENTKYLSRQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5T3</accession>
    <name>I4Y5T3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_22659</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960601.1">
        <property type="nucleotide sequence ID" value="XM_006960539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5T3"/>
    <dbReference type="FunCoup" id="I4Y5T3">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5T3"/>
    <dbReference type="GeneID" id="18470928"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22659"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y5T3"/>
    <dbReference type="OMA" id="PAYPAMC"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="206"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="353"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM19325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="557" mass="63040" checksum="B33A1F1795937FB0" modified="2012-09-05" version="1" fragment="single">GITPPISLASPTDLEKQVDAGLIQELKDQNTIESEQESLNREKVLALVQSLVKEFVKRVSIRNGMSESLADQAGGKIFTFGSYRLGVNQPGADIDTLCVVPKHVSREDFFDVFEPLLKTREEVSVCAGVPDAYVPIIKTTISGIEIDFLVARLALATIPDDLELADDNLLKNLDERCVRSLNDNLTIIIGSRVTDEILRVVPNVQVFRESLRCIKLWAQRRAIYSNVNGFLGGVAWAMLVARICQLYPNENAGAVIAKFFTILYQWKWPHPVLLKEIEDGPLKVRVWNPKIYPSDRAHRMPIITPAYPSMCSTHNVGPSTQEVMRQEFKRGMDILDGIHKGTTTWSQLFNKHEFFSKYKHYLQIIASGQTAESQKKWSGAVESKVRQLVSKLELVDGIELAHPFVKGFSEVFICLNDEEVQHAAEYNPSEEVKERSKKPEEYENKEAEDGIHRVYISTFYIGLAIQPRNPETNEKRTLNLTYPTNEFMKLTKLWDQFVEGEMKIFVKNIKASALPDVVFEGGIRTSSSKSSKKKSKVCDIVNLNTNVLTYFPSDHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5W2</accession>
    <name>I4Y5W2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-phosphotransfer domain, HPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960630.1">
        <property type="nucleotide sequence ID" value="XM_006960568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5W2"/>
    <dbReference type="STRING" id="671144.I4Y5W2"/>
    <dbReference type="GeneID" id="18474584"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61528"/>
    <dbReference type="eggNOG" id="KOG4747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085158_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5W2"/>
    <dbReference type="OMA" id="SCERIQN"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="237" mass="26834" checksum="2C7FC4F74EF4BAB4" modified="2012-09-05" version="1">MSSPSLKLDDKSKNPNERLDSPPSKKEKTEVNSSNKDAPNTTKEDSPKKSDPSHDDKKSEHNQDKGEDTKENVEEEKKEETKQDDKDEKQDDKGIPAKEAKKPDPSNPQGIVDMETFGQILEMDEDENDRDFSSGIVYNFYEQAFETFKELDTALKEEDMHTLHTKGHFLKGSSAALGLIKLKQSCEKIQVFGKLQDPKTQKEISKDEALKQVNEALTSAKDEYSEAEGWLKAFYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Z8</accession>
    <name>I4Y5Z8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960540.1">
        <property type="nucleotide sequence ID" value="XM_006960478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Z8"/>
    <dbReference type="GeneID" id="18474554"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61477"/>
    <dbReference type="eggNOG" id="ENOG502S54B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415154_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Z8"/>
    <dbReference type="OMA" id="GKWENER"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="529" mass="59990" checksum="3BD32EF43D212AEF" modified="2012-09-05" version="1">MSTLDSPRKDQVQPSDGITPKINRTNKFKRPRPAHKVVRSSSSVTDLSDYYPSDNELQSPSTSSPPQTPNLDNIPDSYNNLNGLMLSSNNQNNDALIQTQNQIRELEKRNNELEKRLKESERSYTQTTSQNEDYISVMEDQLKDNDMKLEALAREEKDLRAKDRQNMFTINKLEHDIATYQRQTESARMQANSLQNQVQDVNAEIDSLRDSLREKDRDVREARSRADRYEHEIKKWENERKGYEDALQRIKSQLEIARKSERVLEVQKSENVGLKETIDRLRGDLSHQLTYSGSSQDDNAGQLGSVSRNLGKELARQLTEVDNSAGKTLSNEPSEGEIETIVTTRRRKVKPSISSLRNIETDNNTDSTESPPPYSQGNEFEIVEDVKKVTNRGVQVTPESKTIETQTSTDEDKSNDKEAHSQDSKKSSFWKKLSSNLTFKRRRSVSHTITIYSTIVFLCGMIGGAWILPSTTSSLEAVRSLSGYDDKALFVAYNTFDGASTLLNSDGSLTHFLQTLVWNGLDSSQLFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6A8</accession>
    <name>I4Y6A8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960425.1">
        <property type="nucleotide sequence ID" value="XM_006960363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6A8"/>
    <dbReference type="STRING" id="671144.I4Y6A8"/>
    <dbReference type="GeneID" id="18471787"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33975"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y6A8"/>
    <dbReference type="OMA" id="AYWFMGA"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="497" mass="54437" checksum="58C54E2A5C6DAC5B" modified="2012-09-05" version="1">MSQLEKRQSSLPTLINILNKDNSNRGKPTGIFGFFCRPLFQIVIIGFVCFCGPGLFNALTGLGGGGQADPSIANKANAALYATFATVAWFGGSVVNLIGPIPAMMIGSAGYCLYIGSFLALNIHPGAGAFNIAAGAILGCCAGLLWTAQGSLMLSYPTEDKKGLYTSVFWVIFNLGGVIGSAVSVGTNWESDQGGVSNSTYIAFVVITGVGVLLPLTLRNPKKMLREDGTSVVIERQTTWKTELLNLYRSLVDDPWIALLFPFFFASNWFYTYQFNDFNAALHNVRTRSLNGLCYWLSQIVGAVIFGQLLDISRFNRRWRATFGWCVLFAMVWATNAGFYTIQKEFFHIPDDEIKEMDLKDDGYANRIVLYIFAGALDAAWQTYAYWMMGSMSNDPSKLAFYAGFYKGLQSAGAAIIWAIDGQIGSLGALSSSWAFMAGGLLLALPMVWWRIKPHTTIEDETMVRNIDDVNQAIHESELSNGLGDADPGASQEHFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6C0</accession>
    <name>I4Y6C0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960437.1">
        <property type="nucleotide sequence ID" value="XM_006960375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6C0"/>
    <dbReference type="STRING" id="671144.I4Y6C0"/>
    <dbReference type="GeneID" id="18474526"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61420"/>
    <dbReference type="HOGENOM" id="CLU_2279634_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6C0"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="102" mass="11436" checksum="C5573335D5453A82" modified="2012-09-05" version="1">MVFANFSEEDKQAFFELLDEYFESRPHLFGGTKSKGAPPPVMPRQPPQEQVVALYDYNGSGEDLSFRTGDRMSVVDKPSSDWWTCKLGAQQGLVPANYIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H5</accession>
    <name>I4Y6H5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960365.1">
        <property type="nucleotide sequence ID" value="XM_006960303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H5"/>
    <dbReference type="STRING" id="671144.I4Y6H5"/>
    <dbReference type="GeneID" id="18475749"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70488"/>
    <dbReference type="HOGENOM" id="CLU_169147_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y6H5"/>
    <dbReference type="OMA" id="GRGEFTH"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="62" mass="7144" checksum="8BB6FF4F9720424B" modified="2012-09-05" version="1">MFDSLTNRPNTVPQKQRYAQGRSEFTHLKMPRSRLYYYGYLAVFGTGMVLTANGIRTLIQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6J5</accession>
    <name>I4Y6J5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_66222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960385.1">
        <property type="nucleotide sequence ID" value="XM_006960323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6J5"/>
    <dbReference type="FunCoup" id="I4Y6J5">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6J5"/>
    <dbReference type="GeneID" id="18475097"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66222"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6J5"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="660"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114959" checksum="C64C118FE577940B" modified="2012-09-05" version="1">MTSALKSQTPHLFIPSTPSPLQKSNSDLALNKLKNDAGYRDTVYKDKDAQCQLVIDNLKQKGFIPSNLVDNEVNWFYTSLGIDDTYFKLETVDTISDHIISLYAAKLVAYTKHRPDKSLDIDLQKERENDAIFIHSPKSGSNVEEIIDSKYFNSKDAHWRMETYRSSHLRCYFLAKCKLPETISTNGDVNIRTVADPLFLEKASNNTLDIYQRILNQVDVRAGPVVEGFEIEGSTEHRIVIGYKRGTTKAFFSTLTNLYHFYGLYSTRKFVEHFSNGSVIVSLYLNKDPLTPAPPISHSVVQIVREVSLIYCLPDNPFFSRAAESEPGKGNAVQEATYAYIGYIYITHFCNRLGTAYEALKSILDESNPNHAGVLADLKKRFREETFTKTAILEVIKTYPELVRLLYTQFAMSHYPAGGDDAEQLVPTLSHQRLQEVNVFSDEELHNKLVKSTRNQFELQVLESFMVFNKHVLKTNFYQPTKVALSFRLDGDFLPIQEYPQKPYGVFFVVGSDFQGFHVRFKDVARGGIRILRSRDAENYGTNQRMLFDECFNLASTQSLKNKDIPEGGSKGVILPDLNANPQLSFERYVDSIIDLLIPGSSPGIKEPIVDLLGKQEILFLGPDEGTAGFMDWAAFHARSRGAEWWKSFTTGKTAESLGGIPHDTYGMTSRSVRQYYVGILDKLAMDEENTTKVQTGGPDGDLGSNEILLSKDKTVAIVDGSGVIYDPVGLNRDELTRLATARVMINQFDLKKLSKDGYRVLCEDKDIRLPSGEMVADGTQFRNGYHLRVKAEVLIPCGGRPQAINISNVNQLFDAEGKPHFKIIVEGANLFVTQQARLVLEKRGVILIRDSSANKGGVTSSSLEVLAGLALNEDEYVNLMMYKDGKPSEFYNNYVKDIQDIIASNATLEFNCIWKEHQRLNGQESRTIISDKLSSTLNKLQLELESSDSLFRDIERRKKVLAKAMPKTLVEYVGIDTLIERLPESYQKALFACQISRFCYTYGPAASQVEFYLYMSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y724</accession>
    <name>I4Y724_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_4988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960189.1">
        <property type="nucleotide sequence ID" value="XM_006960127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y724"/>
    <dbReference type="STRING" id="671144.I4Y724"/>
    <dbReference type="GeneID" id="18472510"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4988"/>
    <dbReference type="HOGENOM" id="CLU_002678_42_18_1"/>
    <dbReference type="InParanoid" id="I4Y724"/>
    <dbReference type="OMA" id="RSHQCAY"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="60" mass="7156" checksum="D4D13A8E8A8E6DDF" modified="2012-09-05" version="1" fragment="single">KNHYKSHTVPRPYVCSVCSRSFARKHDAERHFRMHNNDSRPYSCPNCDASFPRSDALRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y775</accession>
    <name>I4Y775_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_33811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960151.1">
        <property type="nucleotide sequence ID" value="XM_006960089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y775"/>
    <dbReference type="FunCoup" id="I4Y775">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y775"/>
    <dbReference type="GeneID" id="18471752"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33811"/>
    <dbReference type="eggNOG" id="ENOG502QQTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987668_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y775"/>
    <dbReference type="OMA" id="GYWEFAK"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697777" description="Protein ROT1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="256" mass="27268" checksum="8322955C9207F5F6" modified="2012-09-05" version="1">MLILLALLSVISVVLSDRPYSDDLVGTWSSGSGGVQTGTGFCTPSEYSFNVPDTTGISYSFTKDGFYEESTYKFNSNASAPQCIQAVLIWQHGTYVINDDNGIDTTPIAEDGRIQVEDPCAASSNVLTTANITRNFQSFLPFDDPVKDKKALQLYDFDGSLLAPMYLISKSPNMLPTGSITNGNRKRDVNSDMEEILEERFLEKRAGGGGRASGGKSSGSGSKGGYAGAGGHSSASRYSHSLFAVLLLSAAILVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7A5</accession>
    <name>I4Y7A5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="10" type="ORF">WALSEDRAFT_21797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960181.1">
        <property type="nucleotide sequence ID" value="XM_006960119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7A5"/>
    <dbReference type="FunCoup" id="I4Y7A5">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7A5"/>
    <dbReference type="GeneID" id="18470899"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21797"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7A5"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="9">
        <location>
            <begin position="61"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="304" mass="34930" checksum="9900878D4ADEAE2D" modified="2012-09-05" version="1">MENSKSDDLLALEYNCLGPGWYYALQKELKSPSFKKLKEFLREEEKKYTIYPPKEQIYSWSRSPIDDIRCCIIGQDPYHGEGQAHGLAFSVKHGVRVPPSLLNIYKELKIEYPDFQIPKHGNLERLCLENGILLLNSTLTVRKDTAGSHGNKGWEQFTTRVLQVLAERHAEKGIVFFCWGNWAKKMLDGAKIDKKKHLILSSTHPSPLSASRGFFNTGHFKKADAWVKERYGKGIDWMVQSADRVDKPKLEEKEAENIDKPSKKTKVDEKVEETVREDKEDEKSDAVIEKDAIEEKDVQSMKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7F3</accession>
    <name>I4Y7F3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_65893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960037.1">
        <property type="nucleotide sequence ID" value="XM_006959975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7F3"/>
    <dbReference type="STRING" id="671144.I4Y7F3"/>
    <dbReference type="GeneID" id="18475064"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65893"/>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302895_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7F3"/>
    <dbReference type="OMA" id="VERDAPY"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="803"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="759"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="889" mass="97582" checksum="92836E4A37C05DD3" modified="2012-09-05" version="1">MKIELQSWVEALEKYDASDYIHALRQFSTMQSRGQSSKIEFNRAVIHASLGDQKGATELFNSALRIDPYFAIAHYQSGVCNFMRGRYEHARSDYEASQKQLRGNSFIDYAQLGLAYKLENTNIDFNIALTYYYSGRPEDGVNQLQIARNGASTDQNSVIDDCMRDEAKGYMPYSVQPGIVFRPSESQIKNLEKKDFIGQAKVLYTDDDGTSPDIPLNQNTSEQSEDVPLSRRLPGGGGTLKRNPTHWQPKLLRRPTAGSRKQSSNETTPVSSGTSTPVTEKGGFFSGLSRQKTERRKAPTEEMRTKTGLTPDEAALGPKNAAMLSRARTLGSSTLAEKRSKSEQDVPTQATFQPLADPARGKGVTLTDVQLPSERMGELKDVSTTQPSPTPPTTDDSRSPSPSLAHTSQPPPQLHHSSSQPQLAPSRARFPTRKTSLKHVHNKFKRNEPQPDVPPLERRRSRSFNEGDDYSLAYTEHAPAEAPNRSNTLFSKISGRSNSTTQSSGINHDNRKGKPSAIDTLSNVPAGWPRSDNSSPQSLFSQTQSHRPPQLPALQIGDDLMHSEQTPKAVDNNVALTITPSTPSVLPDKDFSIKFDERTDTMYDTQNGTSVPSSVSDNSFGNLSNKSTDDSGGSPVDALTALNGGNAANGGPFKPTAPLKIQEKPTLTRQASALRRRGTYGMMQEQQKQGAIDISNSMKKMGIEEGNEENDDGVGSTMIKGMSPVEASSLNAERMLEKGTTGMSPVNASSLNAERMLERKQPEVVRTAPTPPPAQTPPTPAAAPPRSPESKSLNKSENAPSLKVRFKIHYGEDVRGMLVGNETSFEAFIHHILRKFEKRPGSFRVRFKDEDGIKITIQDHSDLELAIDTARLHGNGRSDGKLDIWCEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7M7</accession>
    <name>I4Y7M7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959900.1">
        <property type="nucleotide sequence ID" value="XM_006959838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7M7"/>
    <dbReference type="GeneID" id="18474368"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61165"/>
    <dbReference type="HOGENOM" id="CLU_1628328_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7M7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="163" mass="18620" checksum="01ECC51A16698EE0" modified="2012-09-05" version="1">MFNKKDLQLSEVLVATITSDIFNAINVTSEDAAAEIFEQLCRLFEPLENLPMLHSKFLNSKLEYGKDAYAFYFDLKELFKKLEKSGVTIGKQAQKAKAIQSLPDQLRQMKFQLSQETSKEVSFKDLMGCIIDRYKNYVAVFPPDSATSNNQNIRFLGLCTKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7P2</accession>
    <name>I4Y7P2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959915.1">
        <property type="nucleotide sequence ID" value="XM_006959853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7P2"/>
    <dbReference type="GeneID" id="18473012"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58391"/>
    <dbReference type="eggNOG" id="ENOG502S9QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863825_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7P2"/>
    <dbReference type="OMA" id="NDREEEW"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34723" checksum="B8E556DA06872FA5" modified="2012-09-05" version="1">MRNAVAVTATPDKSRGVNKGFSDDEIDAILQSYLLDVDNKRKAMKLHLDRSVSAFTARSLSILASVPKALHGLTLGEFEDKFGGDLVRAVRGEGVRDAAHDLEDKDREEEWEAARKRKRFETKDGSQSPQPETKKSTRKNTRSKTTTSKSKKTGTRTRSTRSQSKAKEADNSDTGSTTNFPHADTFEPNLDELPDEAEVEAEVRANIVNNADKTKKNEKRRPSIQLVDKFGGLNELPQTSSNETRYMHDTATLFIPLPDGTRLAVDPARAEPEELNKLEGVSDEMRDIVRREIERRMQELVGLIDRWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7P9</accession>
    <name>I4Y7P9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959922.1">
        <property type="nucleotide sequence ID" value="XM_006959860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7P9"/>
    <dbReference type="FunCoup" id="I4Y7P9">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7P9"/>
    <dbReference type="GeneID" id="18474372"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61177"/>
    <dbReference type="eggNOG" id="KOG2338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034867_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7P9"/>
    <dbReference type="OMA" id="YTHYWKT"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="41772" checksum="FFBB38C9E96485D0" modified="2012-09-05" version="1">MSRPAFLKQRKFTAKAKYSDTIRVATWNTLSQSLVKRDLYPGSNCLKLKDRLPRLLEESTKYSPDVLCLQEVDQLDKLKSALAQYNHVDCFGRDGNDNIKKHGLVIFYKESFQFVKKKTVSYDSHTLWPLSRKTNNVGLVVALRTNTSRGFIVATSHLFWHPAFVYERTRQTYILLEQADQLRKELSVDWPILLCGDLNSEPHELVYQVLVDGSIDEKERQRVEMSRVRHSSVLDGYADKPPEQGANLPMTNSIPNENCPTPEQLIAAFKHLPKFESAYDNLNGSEFYSERDTSLTGRRGANEPKLTNYMPKFGNLTLDYILYERKRDIQVEATLNIPSCDSLAPGLPKLDVTASDHLILAADLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T5</accession>
    <name>I4Y7T5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959956.1">
        <property type="nucleotide sequence ID" value="XM_006959894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T5"/>
    <dbReference type="GeneID" id="18474384"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61192"/>
    <dbReference type="HOGENOM" id="CLU_1751113_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="149" mass="16639" checksum="50C47C8B4B60DCC9" modified="2012-09-05" version="1">MATHIYALGGWGIVAISSVAKIAKLLVPRKVYPANDRLPKKKMCQAGKLDYTDNQGLLYNISISFEVKNGIPCHVTANGDVVKLAIEGSFDRLHQMGFAVGSVRFEHDSEDWSSWVDIVTKANQPIPDPVEEEDDRGTWCWFLHPVVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7U4</accession>
    <name>I4Y7U4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959965.1">
        <property type="nucleotide sequence ID" value="XM_006959903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7U4"/>
    <dbReference type="FunCoup" id="I4Y7U4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="18474387"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61198"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049633_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y7U4"/>
    <dbReference type="OMA" id="LHYLYSP"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="266" mass="29088" checksum="E47684F5340FD013" modified="2012-09-05" version="1">MFLSGDISSDKVLVFIAGLTNTLLSVPYVEPLSETLKTSGWGVAQLLTSSSGYGFAHGSLDRDVSEISNAVAELRKQGKKKVVIMGHSTGSQDVLHYLISDGEREGVEAAICQAPVSDREAIDDTIKSYIPLARKMIDEGRQEEAMPREACKWFATPITAYRFFSLFAEGGQDDYFTSTLPSSTFEENFSKVKTPLALIFSGADQFVPEYVDKNSLAKRMQDSSKGGVKLSTVVPDAKHDYEGGLEGSKPTLKLIDTVKNFIEEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y828</accession>
    <name>I4Y828_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_70089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959841.1">
        <property type="nucleotide sequence ID" value="XM_006959779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y828"/>
    <dbReference type="GeneID" id="18475686"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70089"/>
    <dbReference type="HOGENOM" id="CLU_837303_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y828"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="38717" checksum="2C27C7363143C8E0" modified="2012-09-05" version="1">MHYPYLDTQSTPPRIFIRPGVTIDLNSSTKALLEEFCEPKDITTFSDTIESEDEARRTVFALKEMEVHWLSIRVDKLDQHLLKKITELRHLDTLLIHSIKTTGKYHSRVDDIVSLFSGMKNLKHLEFNFEVTDICYDLAKDYDFKHQYRLVEKLGVGCPSLKYVQTITDGMTTSWEIEQSMGYGSRWPVPKQKAGQQRLKNSGDVFSKRKSDFNSRRWFGIGSPVATPFNTFSTYPGLPAYSNNAMNPIEQFYQAQYQNQMNNLMPFGYSMYGSERPFAMPPPAPVVPAWGHELKEYPIWSYDDYNPNDYPDWHRKRHQARPIQKRKTVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y892</accession>
    <name>I4Y892_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959672.1">
        <property type="nucleotide sequence ID" value="XM_006959610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y892"/>
    <dbReference type="STRING" id="671144.I4Y892"/>
    <dbReference type="GeneID" id="18474302"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61042"/>
    <dbReference type="eggNOG" id="ENOG502S268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087365_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y892"/>
    <dbReference type="OMA" id="QKEVYQR"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="180" mass="21202" checksum="34425FE6723EEF30" modified="2012-09-05" version="1">MTLLFQEFPELEALSRSDLEELLQSPSYLDAVYETLPRTEALKKREELLLLSNEDLAKQNMELGEALVALRQETQQSYEEATDAYKRWDEIEKQLKDIDYKTSPNFLIMRLKQAVSQQDELSESIASEFISSANVDDDTDTRQQQQHLDTFVKEFKQVRKLYHKRHIWAEKSNQGNVIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8B0</accession>
    <name>I4Y8B0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_65559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959690.1">
        <property type="nucleotide sequence ID" value="XM_006959628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8B0"/>
    <dbReference type="GeneID" id="18475032"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65559"/>
    <dbReference type="eggNOG" id="ENOG502QSZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y8B0"/>
    <dbReference type="OMA" id="MDKANTI"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="16"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="47484" checksum="B780717D6501461D" modified="2012-09-05" version="1">MKNTTIENDKGKRYAVIAITSYLLLIVGWTDAIFGSLIEPLEEWYDLTERTISLAFLFYVVGSITSSYLSSICIQKLGIRWFIISMTTLYCAGALIDAFKPIFPAYVFGVYLMGVGTGSMQTSATAVLSHFEDGPLMTLVYSNMALGSVISPFIIGAFLQYDIGWHHNFWILVGFAAILIISSWFIFKNFDTHDTEKDDYTLREKLRIVLPSKKLWIGLLAEAGLLTTQDSFSQWIAPYVKDLKGLSNGQPQYTVAGFWGGLMVGRLLLAHGSAKIGKRRSSVTMYIILCALIAGLWKVNSLGGTVTLVILIGFFFGPLMPNTLSIGVECWSRELKNAATSIIMATSLFGSLLAPFALSQAADEFSLKIFPPVLIVECFITAIIVSFTFVTRPIKEEEDILNYKSTKPESVRTSTDFVSDTSPKLKQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E8</accession>
    <name>I4Y8E8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_61068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959728.1">
        <property type="nucleotide sequence ID" value="XM_006959666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E8"/>
    <dbReference type="FunCoup" id="I4Y8E8">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8E8"/>
    <dbReference type="GeneID" id="18474319"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61068"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y8E8"/>
    <dbReference type="OMA" id="AKTVACH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="191" mass="21407" checksum="11C21F380E8A10DB" modified="2012-09-05" version="1">MICQCQRCARCVYSICADICLISLQMDMLWNWDVKDRCIVFSSWQISSAISAIFSIITIILLGVLFEWLKYRMRKLDTSIANSLAIAYNIHTSYKNSNNLNRSAVDIEVDEPTTVQTPAKLIVPKHQQVQRSILYAASAALSFFLMLIFMTYNGFLIAAVVVGAGLGHYTFHREIEVAPSNESSSALGCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N1</accession>
    <name>I4Y8N1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_20815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959580.1">
        <property type="nucleotide sequence ID" value="XM_006959518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N1"/>
    <dbReference type="GeneID" id="18470857"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20815"/>
    <dbReference type="eggNOG" id="ENOG502S7D6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160816_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N1"/>
    <dbReference type="OMA" id="QKIRRDC"/>
    <dbReference type="OrthoDB" id="2581252at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052848">
        <property type="entry name" value="CHCH_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031731">
        <property type="entry name" value="CX9C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16860">
        <property type="entry name" value="CX9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="105" mass="12000" checksum="986610CDE5DBEE14" modified="2012-09-05" version="1">MDSSLSTISQKCSEQLEKYQSCILSNQQQDWNAICKPQRDELTKCADNSVPQLKAVKEKCGSIINNYDQCLQQHKNSSDETLEKECISHLKSLYECTDSVMESFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Q8</accession>
    <name>I4Y8Q8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_58213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959607.1">
        <property type="nucleotide sequence ID" value="XM_006959545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Q8"/>
    <dbReference type="FunCoup" id="I4Y8Q8">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Q8"/>
    <dbReference type="GeneID" id="18472996"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58213"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001321_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Q8"/>
    <dbReference type="OMA" id="WQMQSSV"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="837"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122747" checksum="2FA256B9E9F51232" modified="2012-09-05" version="1">MSSPAPSELCFECSLPMSGQFVRALGNIYHLDCFKCHDCGKVVANKFFPIQSKDSSTSFPLCETHYFKRLDLICYNCNMALRGSYITACGKKYHTNHFTCSICHLIFGPKDSYYEHDQQVFCHFHYSTRFAVKCCGCKVAILKQFVEINRNNLNEHWHPECYMINKFWNVKLARPNSKLLSSSEEESLETPLALLDKQKRMEEHVFRIWTVLSAFEESSAACISEMLRHVSTGAYIIAVRMAGKFIIHVEVLFAAMDKIEDSFIKEGLKSPSHNREARMLCRKTVSFLSILSHTHEAGSRRMGITKELLSLVTGLAHYLKILIRIALTASLKLDRDYADIEALPAFLDKLSLLLQDPISSAQHDNADDERQLKQVSYGYKSMSTSSKKSSVIGRGISSDNPTDLCFACNATIEDDCVRFGLSLRWTLDCFRCDECHRRPILPVRSVRDRQRDRERQRDKRRDQAAESGIAYDSSTDYDAEIAKLERASTSDGGRRLPIEDYYLSRPNPATLAIPPNVSHKAVMAAEKAATKVVCTQCKHTVSHAEKGFTFSTKLEQYSYLLNVALTRLYMVLKTRGAVPPPKQKPIGLENSKSNQGEASPDLLDDQKKRDREAQNASKEVYDSWRDSSELKRIRPQELELDRKLSATARLPRRSTVVESPIGRSAVPSELFPSPIDDHPPIKQPEVQAAQPALTIKPDSGVRIVHENAPNVISELKPQFSNSDNNEIIYTSQTDKSLDSDVVSLVDMPQIMEASQAREQRKSLSRSNKNILMTELSSLESLVVKHAALYLLERSEMSKHIENLDDLLDLVEQKKANTFWGKFFKPKKEQKKTGILGCTLDQLVERAGVETTMTNGQYKLTIPSLFDDLLMAMRQVDMSVEGVFRKNGNIRKLRELVEAIDKEVYNGNLTEESPVQLAALLKKFLAGLGDPIFPHKLYKLYTNLQLEIVDEATRKRILHLLITLLPKSHRDLLEVLFVFLRWVASFSHVDEETGSKMDIQNLAITIAPSVLYPPHSPYNREDTIICNRSIAEYLEDQDEFYCVPEEILPILYDQELFSFATAELTRKDIRRRCEVVFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R9</accession>
    <name>I4Y8R9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959618.1">
        <property type="nucleotide sequence ID" value="XM_006959556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R9"/>
    <dbReference type="FunCoup" id="I4Y8R9">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8R9"/>
    <dbReference type="GeneID" id="18474286"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61018"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012356_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8R9"/>
    <dbReference type="OMA" id="HYAFTEV"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="207"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="873" mass="94652" checksum="48B8971105548F2B" modified="2012-09-05" version="1">MAPIWSNLSRSSSRTDVPSLSSSLPSNVPTPTRRPSADAQGPSKIEIEPEHETVVLRGLPGDSTPFVLRGAVKLHLSHSTEFKDITIQISGKCRTNLQDRHRTSTVNDTHILIDEKKSVMTKAGKHHQTLGAGRHTFQFEFDLHSELPASFQLVSGAASIKYKLKAHAYRPQIIHKDLYNSLPITLLHGLPSEALEFSQTLDIENTWPKKIMYAITLPHKVFAAGESIPISIKFTPLTKGVKVTQLTTIVKEYAETQGKFNKQEDNRMVTTARHQFSPDGEPIPVEMPLFSKRTDTNAMSSPGTRSVPTSPAARPQSNSNLESVRSLDLSNPSSTGESNENPSWRRPLRRAMVGWSDNDPRLAEGPEDLTELNDGEVDSVINVDIPATAVPTHQFWPVQVYHKIKWSCMIQNRDGHQSELRCALPIHILSNRLLQENVIATANARRALFGQSAGAANPQTADEAATAAATADLPSYSNHIYDRVPNANVVTSGTIPSGYGNHTYSPLGGSPAPMSPSDSRPTTPGVPIQGSNRGSSGIATPPDQLIGSSPSSPTNGRTLPTRPQMSWADSEFYMSLGEIARAQSRNASNQQQQAANTRSPGSSRNNSRMGSRQHSRASSRAGSPERGFRNGDLLPQRRGSDRDRRSSEQDISQAISLNDDDDVQPPPPSEAKEKPTRPSFSSSHSLNNLFSGHSSHKLSKSVPKALKPLTSFKSHGHSASSSKIHQQSPLANTSPDNGNEDDDDDVSALNRVPSYDVASRGFLGGGVVPLPEGLPTYDESQTNMQRSSTLDAGSMRKLRQAAANENIVSGNTQNQSLTESLSHMNLGQQGNSAGSEGMVSRRPSRASATSSSSRRPQVKFTLEHDSEDEEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8S1</accession>
    <name>I4Y8S1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI inositol-deacylase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_33412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959620.1">
        <property type="nucleotide sequence ID" value="XM_006959558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8S1"/>
    <dbReference type="STRING" id="671144.I4Y8S1"/>
    <dbReference type="GeneID" id="18471676"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33412"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8S1"/>
    <dbReference type="OMA" id="WGDYKGT"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="3">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="397" mass="44376" checksum="F098FCA95B8A8643" modified="2012-09-05" version="1">MTESKRNAIQDALGNALSDDTNNRPTLVESTQTLSQKEPYSPWKLMNGLAASTLPSTSVSLDSSSSYPRGRAQSDAKTQLRDLEKTSSWSDSWRDWLTGNTKEQDRYLNKADRSIEHDKGDLKSKYEIPKNPLVFCHGLLGFDLIGPTNIPALQISHWRGISEVLEENGVEVLITRVPATSSVEDRAKVLDEQIAKYLPGRDINLVAHSMGGLDCRHLATHMNPIRYNIVSITTISTPHQGSSFADYMIDDVIGRHRLPGLLSNLPNRVVPLFSGDGKAFEGLTTKSMTRFNEQTPDLPTIKYFSYAARHDPGMFDTWRYPWSIIVEREGENDGLVSVKSARWGTFMGTIDGANHLDLVGWVNHARFAWAEFTGRAIKYKPATFYMEIADNLAKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y916</accession>
    <name>I4Y916_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_55079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959484.1">
        <property type="nucleotide sequence ID" value="XM_006959422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y916"/>
    <dbReference type="FunCoup" id="I4Y916">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y916"/>
    <dbReference type="GeneID" id="18472712"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55079"/>
    <dbReference type="eggNOG" id="KOG0285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_72_0_1"/>
    <dbReference type="InParanoid" id="I4Y916"/>
    <dbReference type="OMA" id="FAMCFDQ"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="318" mass="34760" checksum="E79EEF5C82AEF5B3" modified="2012-09-05" version="1">MKIKNQTQAKPDYHPQWKLMRVISGHLGWVRCVAVEPDNKWFATGAGDRTIKIWDLASGELKLSLTGHISTVRGLAVSNRHPYLFSCGEDKMVKCWDLESNKVIRHYHGHLSGVYAMAVHPTLDLLVTSGRDSVARVWDMRTRAPVHVLTGHKGTVGAVATQDADPQIITGSMDSTVKLWDLAAGKAMTTLTHHKKSVRSLAVHPTEYSFASGSAGGNNIKKWKCPEGQFVHNFSGHDAVINSLSLNADGVLFSGADNGSMSFWDYKTGLPFQSMSDIPQPGSLDAEAGIFCSTFDQTGSRLITGCADKTIKMYKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y927</accession>
    <name>I4Y927_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Receptor/non-receptor type protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_58154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959495.1">
        <property type="nucleotide sequence ID" value="XM_006959433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y927"/>
    <dbReference type="FunCoup" id="I4Y927">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y927"/>
    <dbReference type="GeneID" id="18472991"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58154"/>
    <dbReference type="eggNOG" id="KOG0791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_9_1_1"/>
    <dbReference type="InParanoid" id="I4Y927"/>
    <dbReference type="OMA" id="REQRAYM"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="266" mass="30501" checksum="E9C0E02376A4ADE1" modified="2012-09-05" version="1">MMAESIQELDDREEVRLERKSLSKSTSVKYLKLNRYTNILCYDDSLPTTVEYINASVIEFKEFNCNTTNAKRFIATQAPPVRTFGTFYSLILEEGVRDIVQVSNYQENGRPKVDYYLPDDKELQFGDITVKTLSVEDDAECLTTHLEISTNSKAIQTRHILYKNWPDHSAPTSLRSLIGLLGRLDESAPCVVHCSAGVGRSATLIALHEMLRCKNQPLLPFYDDLKGRSYENSDIVYRTVDFIRRQRPLSCEAKQIAWLYQAVNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H6</accession>
    <name>I4Y9H6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959405.1">
        <property type="nucleotide sequence ID" value="XM_006959343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H6"/>
    <dbReference type="GeneID" id="18471641"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33239"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9H6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="16006" checksum="0A37EDAA068AD227" modified="2012-09-05" version="1">MKGREGTIVQLNWIPGHTGIYGNELADRTANEGRTKCNHYTNIDFTLSTSYSAMRRRMRERYTAPLKIEASKLSVIKSNTSKTSAGKLTAAKTAKILNELPRATRCLATQLRTGHFPTTKSYRYRFKLIDSPKCRTCGIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I5</accession>
    <name>I4Y9I5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_65292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959411.1">
        <property type="nucleotide sequence ID" value="XM_006959349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I5"/>
    <dbReference type="STRING" id="671144.I4Y9I5"/>
    <dbReference type="GeneID" id="18475007"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65292"/>
    <dbReference type="eggNOG" id="ENOG502QR04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906748_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9I5"/>
    <dbReference type="OMA" id="IANTIDC"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF202" evidence="5">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="34883" checksum="EE9EBAF5D53EF681" modified="2012-09-05" version="1">MKGEQGSSVDSTRNDKFDRLRPIQIDNVGTVARDHLASERTWLTYVQTSLAIASIGVAITQLFAIKPIDAKDEANPFEAELDQAPLQTRTNQSRTESTRFNNPHRKVEIGDNISLAVIAHAYKPLGGSSNDFPLKMMSRWFKQVGFFVILYDRKSTSWTGDIEVEEYTSILKEVVSTQLSQYSLSKVIIGGYSAGSLIASRVRELDWLDCEVRYLLLSHPLSVSWALNLFRGTQIDNTLHDNLKTHKHLAIWGTNDQFTGVERYRQWSDNLKRGYPNTWSYIEIKGADHFGKSFVDVYNGLIEWITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9V1</accession>
    <name>I4Y9V1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959272.1">
        <property type="nucleotide sequence ID" value="XM_006959210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9V1"/>
    <dbReference type="GeneID" id="18474994"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65163"/>
    <dbReference type="HOGENOM" id="CLU_977287_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9V1"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="30847" checksum="556CDFDAAE3549F9" modified="2012-09-05" version="1">MKISEIKLKHSIKGLKAYEKLALRKFDSDDAWFISDKLRSYDYEGSSIVFTVRLFNGLELTSGVIGQVAPHNYDWLNAKYNTVAKYHMSSHLYGQNLIVKHHSIPSWQLSPEDTSRIAAMADVSEYTNEYFRTLLVEEKGCQVDWNELSDDYRTFISTFEKKTLLHFTGDELDGFFKSIFPSSVAKTGPNGCYYIENVRIKDSNEKLKISPTNLMGEKTENKYPEYAAHGGAFPINIKNVLSPIGALSISGLPNGSLDHAVAYNVITELAAHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA16</accession>
    <name>I4YA16_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_19826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959045.1">
        <property type="nucleotide sequence ID" value="XM_006958983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA16"/>
    <dbReference type="FunCoup" id="I4YA16">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA16"/>
    <dbReference type="GeneID" id="18470813"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19826"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="I4YA16"/>
    <dbReference type="OMA" id="GHFELVM"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="976" mass="107156" checksum="C1FDC298D7F496F1" modified="2012-09-05" version="1">MSTHDEKPVREGEIPSKEQYPQEEEDNSPHSEYSALVNYIQNVELRKSDDAAAEEDEVTYKRPWYAPWKKIEIRQQGASVPEDWLTATQSSGGLSSSDVEPRRKRFGFNELESPEENLVLKFIGFFRGPVLYVMEGAVGLAGGLREWVDFGVIIGILLLNAFVGFYQEKQAGDIVAQLKKGIALRTTVLRDGQEHEVEARELVVGDIVVIEEGATIPADVEILSDYKDKDGSKAAEILAKVKAESKKEKTDDEEDSFGKGPSILAADQSAITGESLAVDKFHGDTAFYTTICKRGKVFARVKSTAPISFVGKTAALVLGANDKGHFVKVMNIIGGTLLVLVIVFLFAVWIGGFFRNTGIAQPRDNNLLVYTLIFAVIGVPVGLPVVTTTTLAVGAAYLAKKQAIVQKLTSIESLAGCDILCSDKTGTLTANKLSIHEPYVAEGVDMDWMMCVAALASSHNVKSLDPIDKITISTLKEYPRATEMLKTGWVTKDFRPFDPVSKRITSIVERDGVTYTCAKGAPNSILKMCATPPQVAQAFRDQTMEFASRGFRSLGVAVQEGNGDWQVLGLLPMFDPPRHDTAATVGEAIKLGVGVKMLTGDAVAIAKETCKMLGMGTNVYDSHRLIGGGSMAGSEMHDFIENADGFGEVFPEHKYQIVEMLQHRGHLTAMTGDGVNDAPALKKADCGIAVEGASDAARSAAAVVFLDEGLSTIITAIKVAREIFHRMKAYIVYRIALCLHLEIYLTLSILIMNETIRADLIVWIALFADLATVAVAYDNAPYALTPVEWQLPKIWIMSTVLGAILAAGTWILRGTLFLNNGGIIQNWGGIEHILFLEVCLTENWLIFLTRTGEGEFKWPSWQLTGAIAGVDIIATLFTLFGWFHADRDAHNGHTDIVTVVKVWAFSIAVMVVCTLAYVIMNNLKWLNNLGKRQVGKIDRRVEDFMNELQRITIVHERSDRDVYRLYGRNQGLDSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA20</accession>
    <name>I4YA20_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_33035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959076.1">
        <property type="nucleotide sequence ID" value="XM_006959014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA20"/>
    <dbReference type="STRING" id="671144.I4YA20"/>
    <dbReference type="GeneID" id="18471610"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33035"/>
    <dbReference type="eggNOG" id="ENOG502S3VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109939_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA20"/>
    <dbReference type="OMA" id="PNEIFRE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697879" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="219" mass="24103" checksum="FF4496DE3761D176" modified="2012-09-05" version="1">MFKSATLLVLLSLSIESLAKVLPTEPSPDSKWAVGSKQTIQYKIDNDDKDTKWDKFSIELMTGPDLYTIFVGKVAENITVDDDEKKGKLEWTLPETVNPHSQIYFLQFYNSDNATDKTWSTRFTITDTDGSSVPPAHSTQPKSGKDTPWGIGLLQPGHVDQDTLPLHHNYPASDAAEEKIKDGGGSKQDEVEPDSSGYSAFKTSALFVSALTIVTVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA21</accession>
    <name>I4YA21_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_33036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959077.1">
        <property type="nucleotide sequence ID" value="XM_006959015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA21"/>
    <dbReference type="FunCoup" id="I4YA21">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA21"/>
    <dbReference type="GeneID" id="18471611"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33036"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA21"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="367" mass="40595" checksum="940898ADC776F176" modified="2012-09-05" version="1">MSTVQKIKEIEDEMARTQKNKNTNYHLGQLKAKLSKYKKELLTPSSGGGGGPGVGFDVAKTGLASVGFIGFPSVGKSTLMSKLTGTHSEQAAYEFTTLTTVPGTMNVFGAPIQVLDLPGIIEGAKDGKGRGRQVIAVSRTCNLIFIVLDVLKPLNDKGVIERELEGFGIRLNQKPPNLSVKKKEKGGIAITNTVPLTQIEHEEIKAVLSEYKIPNADVMIREDISVDQLIDVVEGNRVYIPCIYVLNKIDAISIEELDLLYQIPNSVPISSSQWLNIDELIEIMWERLQLVRVYTRPKGRAPDYTAPVVLRRGRCTVEHFAHAIHKEIAKQLKYAIVWGKSSKHPRGQKVGLDHVLDDEDVLCLVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA25</accession>
    <name>I4YA25_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_39282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959080.1">
        <property type="nucleotide sequence ID" value="XM_006959018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA25"/>
    <dbReference type="FunCoup" id="I4YA25">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA25"/>
    <dbReference type="GeneID" id="18472108"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39282"/>
    <dbReference type="eggNOG" id="KOG2188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008720_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA25"/>
    <dbReference type="OMA" id="CNSYGSH"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="681" mass="77272" checksum="FF134D5F461FE743" modified="2012-09-05" version="1">MDKRLTNASQDDSEEYSMMIEATLSEMSSHELALSTDPECALMVEHMLKRVGDFEKRVFADALMGQINAVISNSFGSHVIETLLETSKGTIMRESNGDIAQPPNQDPESVGQLRTFTTLLNDLVEEILPFVGDLILNQNATYPIRYLLHLLSGDTSENVLKRSKKSKSWLNRNDNFDAVNEQQYEDEEYRPPKHFKELFNRLRKALFDSFSSSAEIRAFGVSDHGAPVLQLLLQYERNNGENDKTDSFLDSWLDGLIAQLQSSEETKQSGHITTTLLDTTASHTTETAIECASSSVFEEIWKLYFTAKGGTRCMKHPVGNFVYAKALARLGTDENLNEEFVNAQLNETISLIRESGSKLIKTGRSGPLLAISDVVVARNVFKDEVLSMIMHCFGLSTTSTAQAKHIIPCILEMKRWKSYRRFHKETFENDEADEESSGDERKTNKKKKKDSGDDDIYTVPGAQLIQSIYQYGSPLNDKIIESVINLDTDKLLEICGSSSASRIIDGLIESDNIAFKYKHKLRLKLVGNYHLMADMRVGSRVAEKIYETSDGYFREKIANSLIEHEDYLAGSPYGKYLSRKVDLSLFRRRYDDWKEKTAQEIKNAGLNKINNIKKAPRVFNGKLANEMLSINQSEDKRGSKSSKKRKNASNEDTTSGETEDKADTRTRQEKREEKRQRKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA63</accession>
    <name>I4YA63_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959116.1">
        <property type="nucleotide sequence ID" value="XM_006959054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA63"/>
    <dbReference type="GeneID" id="18474132"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60740"/>
    <dbReference type="HOGENOM" id="CLU_1620333_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA63"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18509" checksum="19A48AE9766316FC" modified="2012-09-05" version="1">MEPQCAYIIEFKSLASNLLIFKKGVQYPDYELDVNVTRSRMTFLELPYQKRLARVHGPKLLLGKGYKMSINGEKLRMHRDSHRSTCLWFDLLDKSPCVVVKGGHGDGSTYRITNILTNEILATFQPSGPSYGCMNLNAGGYDNQNLIALFTAMAIMIRLGIDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA66</accession>
    <name>I4YA66_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959119.1">
        <property type="nucleotide sequence ID" value="XM_006959057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA66"/>
    <dbReference type="GeneID" id="18475596"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69527"/>
    <dbReference type="HOGENOM" id="CLU_2039877_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA66"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698702" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="121" mass="13114" checksum="3998FFE1CE366EB8" modified="2012-09-05" version="1">MKLSFAAATLFVISTVFAAPLLDEAANGLGKKILKRDPLADESLNGALKNAVKRDNKEEKRLLNESLNGALAHAIKRDTKEEKRLLNESLNGALAGALKRDNKEEKRLLDKSLNHALAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA80</accession>
    <name>I4YA80_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_39359</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959132.1">
        <property type="nucleotide sequence ID" value="XM_006959070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA80"/>
    <dbReference type="FunCoup" id="I4YA80">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA80"/>
    <dbReference type="GeneID" id="18472114"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39359"/>
    <dbReference type="eggNOG" id="KOG0338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_3_2_1"/>
    <dbReference type="InParanoid" id="I4YA80"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="236"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="634"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="801" mass="90532" checksum="BB193D3D3600939C" modified="2012-09-05" version="1">MNKNKVVDDFIGTIDSDEEIDEIEELEEPEQPKLSKKEQIQRRKNKEVIQDKPVSSKGKEIELEFDFENINNHLNLAKSDELQSINSSSIDNIIKKKLNTLDDTLKEKRKSVLDKNDIDDEEEDVNDDDTGSENDENIIDDDDDDPLASSDEENVEEDDEDDEDVEQDQKEENSDEDDSEEDEDEERKKNEFFAQQPTASTNKKNTFTSLGLSRPILKAISGLGFTHPTPIQKTVMPVALAGKDVVGQAVTGSGKTAAFILPVLERLMYRPKTSSKGGETRVLVLCPTRELAQQCFEVGQSLSKFMGDISFCLCVGGLSLKLQEQQLKQRPDVVIATPGRLIDHVRNSPSFTLDALDILIMDEADRMLEDGFKDELDEIVKECPKNRQTMLFSATMTDKVDELVRLSLNKPVRLFVDPKKSTAKGLTQEFVRIRSNSKNDLKERTATLLSLCRRTFKQRTIIFFRSKALAHRMRIMFGLMELNAEELHGDLSQEQRLNALERFKNQKSDYLLATDLASRGLDIKGVETVINFDLPNQIEIYLHRVGRTARAGTSGRSVSLIGETDRKMLKNIVKRSSAQSTDSIKHRIVPTDVLSDVAELVESLQDQIDEILKEEKEDRAIRVAEMELQKSKNMIEHEDEIKSRPARTWFQSEKEKKDSKEAGKEQYNANFDKGDADKTKKTHDSLGRKLNAFSGLSRKDRRKKEMKEELEADKNKSKGIDYAVRSAKKAVKPQRMSVLADSSAKSSQAKSQPSKKRKSTGFEEDKSVKAPKKSKEGERAKPGAAIGRSNKKPRAKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAA2</accession>
    <name>I4YAA2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959153.1">
        <property type="nucleotide sequence ID" value="XM_006959091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAA2"/>
    <dbReference type="GeneID" id="18474149"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60763"/>
    <dbReference type="HOGENOM" id="CLU_736095_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAA2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="376" mass="41120" checksum="C06CAD4C1627790C" modified="2012-09-05" version="1">MLDLVALVDKQVIISSDAMLALSICILSLIIVVLVHLTVTRILLVRPEVAENLRKPTACSVLQNQVTTVGLISDDFQPDGACWVNEMHTINQTTLDEYLQEVGQPKLNYTIYMTGQSASEENYHNGDNSLASDLAGKAILTRASYPRMNTLLVSYQAARLATGLVAHVILTGIGTLTSSFGVYRNDWEMTATGFIALFVATGLGYSTSPFPTKGMTQTANNASTHEREIGARDALKQHVNLSGKGMDSDISAWQLMGSENSHHQYQKIGDSNGYGHQILVLFRKSNLSVKSKRRDGRAGAYGLRYTCYEPNKDPFLQQSHSGAIYNANNPENFVLGTLTIHGTVIGCVYFDLPWNTLNRNGKIELLTAQNPDTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAD3</accession>
    <name>I4YAD3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="6">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_19685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958907.1">
        <property type="nucleotide sequence ID" value="XM_006958845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAD3"/>
    <dbReference type="STRING" id="671144.I4YAD3"/>
    <dbReference type="GeneID" id="18470807"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19685"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_1"/>
    <dbReference type="InParanoid" id="I4YAD3"/>
    <dbReference type="OMA" id="CKYFPDH"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000940">
        <property type="entry name" value="PRK00094.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000942">
        <property type="entry name" value="PRK00094.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF1">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="9">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="425" mass="45620" checksum="1B4BE791C4B49983" modified="2012-09-05" version="1">MTPVGGDEKPSLSRSSSFKRKLSIPSVGYKRVLVLGSGSFGSCLADHLADIGHQTRIWARNKDVVDSFNNNHKNPKYLTDHTFSKNLKAVGPEFPSFEDLLLYNVIVMAIPSQSMSSVLKNLVPLFEAKKDKAPLLVFANKGIESGSCFLPIEIIERECGKEIARVSTFLSGPSFAKEIVQRMPTQVTIASFSSQHAEQACEVFHQGHFLTFSSTDPVGVELAGALKNVYAIASGVASGLGFQQNTRAGLVTRASAEMQKIGAAFNADPLTFLSLAGVGDLFLTCSSENSRNFTVGKRLGEGEKLQHILDTLGSTAEGVFTAEAVHELLKRLEMSAPIAEAVYDLLYQGASAADMADRLMGLPSMPELARPMVRRSSHSERFMQAVGVLSPAQSPSITPSVTPGGSPPHSPKPQNTGINALPEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAL4</accession>
    <name>I4YAL4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_19657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958906.1">
        <property type="nucleotide sequence ID" value="XM_006958844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAL4"/>
    <dbReference type="FunCoup" id="I4YAL4">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAL4"/>
    <dbReference type="GeneID" id="18470806"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19657"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013572_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAL4"/>
    <dbReference type="OMA" id="LIGWLEM"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000051">
        <property type="entry name" value="DNA2/NAM7 helicase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="75"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="360" mass="40583" checksum="469C44C925CE54A9" modified="2012-09-05" version="1" fragment="single">MTAGLEADFIKFDEPDAIDKGKKRAYEAAEPSTSKPTKKGENGKSRKEIEKQRSKKAPWMADVDFDNLRTASELLHREVNAFTKFISPSLTEHKTREYTIECIRRCITSRWADAEVFAFGSFETRLYLPDGDIDLVVMRKSVNQYNKQSMLHTMASMLRQANLAQSIQVISKARVPIIKFTSSFGGYPIDISLNQTNGVDAGRMVNEILDRYPAARPLSMLLKCFLSQRSMNEVYTGGVSSYSVICLVVSFLQMHPKVRRGDINPLDNLGVLLVDLLELYGRNFNYDVTGISIEGAGYYFSKSSRGWHQYGQPYLLSIQDPQDAENDISKGSFNILNVRKVIAGAYDMLTNKLYAQASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB16</accession>
    <name>I4YB16_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958831.1">
        <property type="nucleotide sequence ID" value="XM_006958769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB16"/>
    <dbReference type="STRING" id="671144.I4YB16"/>
    <dbReference type="GeneID" id="18474052"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60608"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB16"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="420" mass="46311" checksum="B9414C8E7E8FEE45" modified="2012-09-05" version="1">MAVDHIIIGGGVVGLAVAQKLSQRFPTRSTYLIERHQRAGEETSSRNSEVIHAGIYYPQNSLKTQLCVRGRKLLYERCKTHNIDHKKTGKLVIGTSASQYAYLRKLHAHTQLPEVSVPTQLISADQALDYEPDLSKSVTAALYSPETGIIDSHGLMDSFEQDITDAESSELVYGTNVVRIDPYNIDNVSRKGEGDDRGYVVQMLTEGSDTTDALLARSVINCAGLNAHTMLNMVLPENEQRKIWYAKGNWFQYKGPGVENVSHLLYPCPEPSLAGLGTHLTLSLDGSVKFGPDVEHLPESDAIDYWKEHLKPSEKNLPKVIEAVQKYLPGVNPDGFSPDQAGLRVKRNQPSSNQFSDFEIVHDTENTPGMISCYGIESPGLTACMAIAEEIERRLTNDVWGAGRGNRVSEAGNSSLNDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB50</accession>
    <name>I4YB50_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958864.1">
        <property type="nucleotide sequence ID" value="XM_006958802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB50"/>
    <dbReference type="STRING" id="671144.I4YB50"/>
    <dbReference type="GeneID" id="18471074"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29107"/>
    <dbReference type="eggNOG" id="ENOG502QUVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039338_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB50"/>
    <dbReference type="OMA" id="WKYDSGA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="185"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46906" checksum="8C35D0C814F06359" modified="2012-09-05" version="1">MIHTQSQRRRSSIDPSKLQPMFKVEHKPGPQFNVMFIGAGNINFGSDEGPWNHSARIENKWGTRLRVTALIDPSKERADKELEKKRASFVAVAYNDTKWFPNLAEAHANLSPAEQPDAVIVGAPPQFRGGLNPPANLELDLLEKFPDAALFLEKPVTTGPSAEAVEVGKKIAAAGNVVSVGYMLRYSRAVQTMIKIIEENNLTVMGTVARYIAAYEKIAKDDWWDKSRSCGPIVEQATHFCDLSRYFGGDVSLDTVQAHSVEWNEEPGKLSKMPIDEEKIKIEDRIPRFTTANWKYDTGAVGTLVHGVALHDTDYYTELTVYTDGHQLRLVDPYNNPALYVRKPGSNAESHMSFANDDCFYSEISNWGDEIEKHEEHNQGEDLDTRILSTYEDAVQSYELTWAIRNAAEAGRKFPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB97</accession>
    <name>I4YB97_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958594.1">
        <property type="nucleotide sequence ID" value="XM_006958532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB97"/>
    <dbReference type="FunCoup" id="I4YB97">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="18475526"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69115"/>
    <dbReference type="eggNOG" id="ENOG502SCMR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151392_1_1_1"/>
    <dbReference type="InParanoid" id="I4YB97"/>
    <dbReference type="OMA" id="MIQGTVV"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="72" mass="7892" checksum="56AA20A7B8897730" modified="2012-09-05" version="1" fragment="single">MLSRLVHYGVDAVLLSTVLAGVKRSTGFTPDVEKFTEEETTKSIASKYLGVGEFCYDTVTGYAVNSSYFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL1</accession>
    <name>I4YBL1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_32797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958701.1">
        <property type="nucleotide sequence ID" value="XM_006958639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL1"/>
    <dbReference type="STRING" id="671144.I4YBL1"/>
    <dbReference type="GeneID" id="18471562"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32797"/>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_0_1"/>
    <dbReference type="InParanoid" id="I4YBL1"/>
    <dbReference type="OMA" id="CGGPYWE"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="81"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="206" mass="22920" checksum="367B3643EC3A47A2" modified="2012-09-05" version="1">MKAPSYGLALARSFATTRSIAGQDLEASRPIPATRIAQEGSNQLSLETPRNGVEYALTTLDKVKNWGQTGSLWPMTFGLACCAIEMMHMATARYDQDRLGVVFRASPRQSDLMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYSPGCPPTAEALLYAMLQLQRKIRRNRTATLWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC00</accession>
    <name>I4YC00_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_64439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958521.1">
        <property type="nucleotide sequence ID" value="XM_006958459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC00"/>
    <dbReference type="GeneID" id="18474927"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64439"/>
    <dbReference type="eggNOG" id="ENOG502QVPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190674_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC00"/>
    <dbReference type="OMA" id="HGHINTH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="233" mass="25199" checksum="6C0CD46B170C7C82" modified="2012-09-05" version="1">MTRGSQTDLGNINSYGQQTPSVDTLQHIPPRMFADSQSSSSTSKFKFPASILNESPEIHRQTHADVQPPSHNHTQQATIANQGKQPISRVTRACDRCTQKKLRCDGTIVPDLNGLPPTVIKPCSRCAHAGLGCEYTRVQKRRGPSPGFKRRKLSNESTTSGASSRTLHSPASSVDSSDHFAQAQAQAQHSYSQPRKVVTLPTSAVLTSQRQPSSGAGFKLPPISNWFQGGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC25</accession>
    <name>I4YC25_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958545.1">
        <property type="nucleotide sequence ID" value="XM_006958483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC25"/>
    <dbReference type="GeneID" id="18473971"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60475"/>
    <dbReference type="HOGENOM" id="CLU_1856849_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC25"/>
    <dbReference type="OMA" id="QLFEWVA"/>
    <dbReference type="OrthoDB" id="3337860at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="15417" checksum="367F6DBDFFC755A4" modified="2012-09-05" version="1">MSDYNYNDVLLLTISDPNPVYTITQVFGAVFESTVEDLSRPSSPVSVQAPSFGMSSLKIEDKSSDPAQDIRKRSERYRERALDRLKDAAREKGGNGVIGVKCEYTPSGFDGDVQLYEWVASGTVVMLKLKQQMVRMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC35</accession>
    <name>I4YC35_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_18669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958414.1">
        <property type="nucleotide sequence ID" value="XM_006958352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC35"/>
    <dbReference type="FunCoup" id="I4YC35">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC35"/>
    <dbReference type="GeneID" id="18470777"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18669"/>
    <dbReference type="eggNOG" id="KOG3471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="InParanoid" id="I4YC35"/>
    <dbReference type="OMA" id="MSEKLMM"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="363"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="449" mass="51473" checksum="4DF118DE07407F6F" modified="2012-09-05" version="1">MNELLVNYLKGLSKFNLNRLFNDKSSTLTIYRLLDDLNKQIISSLLFSSKLLDQSTLELLYKDADLVPLIELNIIDNSNGSITLNEQFKHSLKQILIGREIESLSNSITTTIEQLDTFATQQWELILHYMVGSYNSTPSKGVLFLLEKSNLIYTANKQHRISSKGFQFLLEDVQVQLWQLLLEYLSLSEIRQMDLVEVLSFLFVLGTLELGKDYSIESLTNTQQAMLSDLRDYGLVWQRKTSSKRFYPTRLATTLTSSAPPLLPTTESSSFTTSSDNKRFIILETNYRLYAYTSNPLQISILNLFVTLKARYPNLVIGVITRDSIRSALSNGITAEQIIGYLTSHAHTQMHRNNPLLPVTVSDQIRLWELEKNRLKADDGVLYAEFRSQPDYEILLNYAKSYDCVLWSNDIKRMFFVTLEGHQIVREFVRRRIPGNNNSSTSSQTPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC76</accession>
    <name>I4YC76_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_18424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958238.1">
        <property type="nucleotide sequence ID" value="XM_006958176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC76"/>
    <dbReference type="FunCoup" id="I4YC76">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC76"/>
    <dbReference type="GeneID" id="18470766"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18424"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="InParanoid" id="I4YC76"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="195" mass="21913" checksum="D5C6EC193572A6BC" modified="2012-09-05" version="1" fragment="single">ENKRNFVETIELQIGLKNYDPQRDKRFSGTIKLPHVPRPRMKVMLLGDAADIDRAKLIGLEFMSTEDLKKLNKNKKLVKKLAKSQDAFIASEALIKQIPRLLGPGLSKAGKFPTPISHSDDIEKKINDVKSTIKFQLKKVLCMGVAVGNIDMAEDEIVANVVLAVNFLVSLLKKNWQNVKSLHLKSTMGKAHRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCA4</accession>
    <name>I4YCA4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_18648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958248.1">
        <property type="nucleotide sequence ID" value="XM_006958186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCA4"/>
    <dbReference type="STRING" id="671144.I4YCA4"/>
    <dbReference type="GeneID" id="18470776"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18648"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2265798_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCA4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="103" mass="12242" checksum="2D9AF82A40DF1321" modified="2012-09-05" version="1">MYELTSDLQNYKLNHNLDNKNKKSIYYYNEPVNKHIFRSSGQANCQSTSREFKCSICDQQFSRNYDLKRHQNIHLLIKSYTCNCGKTFSRKDALKRHLLIKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD8</accession>
    <name>I4YCD8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958325.1">
        <property type="nucleotide sequence ID" value="XM_006958263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD8"/>
    <dbReference type="FunCoup" id="I4YCD8">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCD8"/>
    <dbReference type="GeneID" id="18473907"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60355"/>
    <dbReference type="eggNOG" id="KOG3440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="InParanoid" id="I4YCD8"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="129" mass="15221" checksum="18291F922C68EAC5" modified="2012-09-05" version="1">MVNPLKLSLAPFIKGSLRKTLEPIGKGYLNLAGFRQVGLRYDDLIQEENDEMQKALARLSPREEYDRAWRLRRAINQSILHKDLPKEQWSEDEASKQRYLTDRITEVANEHNERAMFDNPEYKIQTSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD9</accession>
    <name>I4YCD9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_38232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958326.1">
        <property type="nucleotide sequence ID" value="XM_006958264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD9"/>
    <dbReference type="STRING" id="671144.I4YCD9"/>
    <dbReference type="GeneID" id="18472054"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38232"/>
    <dbReference type="eggNOG" id="KOG2449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="InParanoid" id="I4YCD9"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="512" mass="56188" checksum="765E86147E4A419B" modified="2012-09-05" version="1">MSILNKNWSALSKPKTTLNYIHGQFKESKTKTYHQVRDPSTDQLITSTPESTDAEFNEAIESSKDGYQFWKNTSLLSRQRVMLNFQQEIRNNANDLAITITQEQGKTFSDAHGDVFRGLQVVDYASSIPTTFMGKMLEVSNNMDTFTRKFPLGVCAMIAPNNFPSMIPNWVISLAAVTGNSLILKPSERDPTASLLLAELAQKSGLPPGVLNIINGTHPIVNHLTSHPDIKAVSFVGGDNAGKHVYKRATENGKRVQVNMGAKNHGIILPDANKDHALNSIISAAFGAAGQRCMALSVAVLVGDARNWKNDLINKAKALKVGNGFDQSNDMGPVISKQSKQRIENLINQSSKQGANIDLNGTNFEVKNYENGYFVGPTIISIPHTEFDIYKQEIFGPVLVILETETLDQAIDLINKNKYGNGASIFTESGSAARFFEINAEPGQIGINTPLPVPLPFFSWSGNKASFAGENSFYGEQGINFFTQTKTVTSMWKPSDQTTSLEKASLSMTYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCJ6</accession>
    <name>I4YCJ6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958375.1">
        <property type="nucleotide sequence ID" value="XM_006958313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCJ6"/>
    <dbReference type="FunCoup" id="I4YCJ6">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCJ6"/>
    <dbReference type="GeneID" id="18473920"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60376"/>
    <dbReference type="eggNOG" id="ENOG502S7S3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCJ6"/>
    <dbReference type="OMA" id="FHPAEPQ"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="6">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="118" mass="13084" checksum="50F9EC2E750FA197" modified="2012-09-05" version="1">MSINWLQRALPYLPKNVLNASTNPASGKGFYRVVLTRSAIGLPKESQRTLEALGLNKRMSVVLHPHSADTAGQLLRVKELVKVDNIYGNDLVQGRVRSISGPSSGFENIGNSQDRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCU0</accession>
    <name>I4YCU0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958089.1">
        <property type="nucleotide sequence ID" value="XM_006958027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCU0"/>
    <dbReference type="STRING" id="671144.I4YCU0"/>
    <dbReference type="GeneID" id="18471474"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32362"/>
    <dbReference type="HOGENOM" id="CLU_702494_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCU0"/>
    <dbReference type="OMA" id="WIYVNDA"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="44632" checksum="E1A4D2D9E74F1F21" modified="2012-09-05" version="1">MSFGKLPNELTFKIIGYLDISDIINLTGICKHLREIAISDALWSDINQRVIGEHVDINAYAESINASQYFTYISLFRHAINFIGIHAGDVYPQGHILNWSINRTTPESEGNLLFMRNRFNPSNEFVQELDNLGYMITNDGKLIYRLDEVIDAGLNTHIEDLPDLLVKFTGNITNPVVAYDVESGEEKVTKYTQESVPIDSLDNINLRTYPSRELCHLVERRTLNTINVHTFHRPYPWPDDEPLRTVKLDTSRLDRDPLEGFFSAEYGSHGIEILAAKKSVQEGSNTLEFVKVTGDNNVPRGLVSIRANLDQEIRDSELLEDSDIRVSSDDNLPWPLTCPTRPIGKSYSAQGKIANSEHHSPRSTPVIVHIENPDVVYVSWTELRNTIVIKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD03</accession>
    <name>I4YD03_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958147.1">
        <property type="nucleotide sequence ID" value="XM_006958085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD03"/>
    <dbReference type="STRING" id="671144.I4YD03"/>
    <dbReference type="GeneID" id="18473852"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60270"/>
    <dbReference type="eggNOG" id="ENOG502SC55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1429035_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD03"/>
    <dbReference type="OMA" id="RWISAHI"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697859" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="190" mass="21566" checksum="9B6650C511564666" modified="2012-09-05" version="1">MKLLQPALIFGFAATVTALLIPSEFQISRIMDNLFTGYSQKADSYNRASQLPTISDLLTLQRGSLFYDYVREVSQVERLLDNHATKLTVFAPTNKAIVNLHRRPHQVEHSGVESMRIWENAMTSSVRNWVESHIVRSSDLEINKTYDALSQTKITLTERDGIKLVNGIKVLDIKTADNGELYVIEDVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD37</accession>
    <name>I4YD37_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial outer membrane translocase receptor TOM70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_60284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958180.1">
        <property type="nucleotide sequence ID" value="XM_006958118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD37"/>
    <dbReference type="FunCoup" id="I4YD37">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD37"/>
    <dbReference type="GeneID" id="18473863"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60284"/>
    <dbReference type="eggNOG" id="KOG0547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017516_0_1_1"/>
    <dbReference type="InParanoid" id="I4YD37"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056413">
        <property type="entry name" value="TPR_CcmH_CycH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23914">
        <property type="entry name" value="TPR_CcmH_CycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c-type biogenesis protein H TPR" evidence="13">
        <location>
            <begin position="404"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="567" mass="62743" checksum="93D7BDDA3964F095" modified="2012-09-05" version="1">MSSSTSKIADWASKNKNLIIAATAVTVVGGAAATYYYQSSTGVSTTSEKKKKSKSKNRKKKSANNGPSPANEPLLEELSLEDRNKVAQDYKSKGNKLYQQHEWIEAANSYSKAIESATKPEAVFYSNRAACYNNLGRYEETVNDCNEALKLDSEYVKALNRRAQAQEQLGKLTEALNDFTAATIIDQFRNESASKSVERVLKKVAEAKAKLILQSRGEKLPQISFIQAYLNAFRERTPTAIPDDSPAGDLDLKEAFNASEAKDFKLSRTKVEESLSKGLSSTQLEAEALNLRGTFYFLLNNPVKAIADLEKSVELWPEFSQSWVKAASVYMELANPQAAFKAFDTAIEKNPVDADAFYHRGQVYFILSDFNKAIENYEKSVEIDDSFPLAQIQLAVAQYKNGNIAKAMVIFRSSIKKFPAKSDVYTYYGELLMDQGKFEEAVEKFDKAIELDGDKYPVNVLPKINKALAIFQWKQDFAGAESLVREAVASDPENDVAIGTLAQLCLQQGKIDEAIEAFEKSAQVSRTEPELVNAITYENATRAQAHFIKNHPSAAAKLGPLAQSMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD58</accession>
    <name>I4YD58_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_68806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958198.1">
        <property type="nucleotide sequence ID" value="XM_006958136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD58"/>
    <dbReference type="STRING" id="671144.I4YD58"/>
    <dbReference type="GeneID" id="18475475"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68806"/>
    <dbReference type="eggNOG" id="ENOG502QTWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003080_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD58"/>
    <dbReference type="OMA" id="SEAHWAQ"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="652"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130593" checksum="2D7551BAEAD917E0" modified="2012-09-05" version="1">MFKVRWNRKKSEQTTPSSPITPLHPVNDNLASPARASFGDGLHPYSQSQPSPVPVSPVTPTSNAVLADEEEDCDNCPVCLEPLSFSFRLPGEKPHIVPVCGHALHDQCFTQVYGVIPSAKIPSKSLGVCGICRKPMNLSDEADVQIKGKGKTNKLDKLAGIASTPNPRDLQSSQSNASLKNQYQRNNTGSTLSLAQLQQQHLDSPLDPLDSSADDAIPAAPSSSSNTSISNNSKSSLGELISPNISIKTEFNAAIRPHVDQKSSITAIVTVKIPSRQAESNHIQDSYHPSLIRYQQRQSALYNDDTVSQLRRSDSRMSADNASINSTPSTFSVQPQFQPQPQPQQPPPQQPPQSQQSQQRPLKSVTTDLYSRILDWKGNNPHSFGSLLLYSLSLTIRRSTQSQTAQVFLFENALICVSEDRKSHPMKDGRRVLKLKGKIYISNIRRATSIGDTALVLETETDDFRDLTLMFMMRDEREQWKAQFDKLIYSSVNIQHHQPQPQQVNTLQNQQTEQSPESPASSLRERIEKERISRLLTPQLGNNNRQSQQTSFSAPQVPFTAPLSPVSLPHSPRSTAPSSYGKASSIATSGISTNPSDVSAFGLAYAGEGGGNKARESMRSSVSANVSANLSEHSLVQLAPHDGTLHPHAPADVVLILPLPTSQHGSPTLKLRFLKSSLEFVINKLGPRDRICVVTFRSMQGGALRRTPFITPSSINGKQKLSRFLETFGNNWDDSVYGIDGAPDPFKVGTKADEKTDVVTAMNAALDGVLQRTSKNAVTGIFLVSDNQDPTRRAQMELVLARAEAASVPIHTLGWSRVHDPSSLWLLSSHTGGTYTFVKEWNQLRDCIAGAVGGLFSVAATNMKLHINVLDWPMVRVRKVSPSTSTIVSSDGNEVHVELGEIHFGEQRELLVEMDLIHPAKATIGSSGLNTKRLSRYSTQANVNSNIQDGLAGLTVGETMTDAYDDLIDEAALFEVDASYHDPNVGRSVSRLVQPVLLTMTIHPNIMTDNQSTIGSSINMTSQRLNAILGNPDANVIRRRMELLSSDMITRALILISRKNNGQAQRLLTETVRLVRMAIANLINSTSFSPNANSPSMSVSAGRFKKDHSILYTADILEAILFELETLLEGLEEHKENFEREQRNLGAQQAMILRDQKSWTGRSPIERLFWNFDNSRGLLVKSLEWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDF1</accession>
    <name>I4YDF1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-splicing endonuclease subunit SEN34</fullName>
            <ecNumber evidence="3">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-splicing endonuclease subunit Sen34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_7968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957737.1">
        <property type="nucleotide sequence ID" value="XM_006957675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDF1"/>
    <dbReference type="STRING" id="671144.I4YDF1"/>
    <dbReference type="GeneID" id="18475833"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_7968"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155632_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDF1"/>
    <dbReference type="OMA" id="ICRCHTE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000002">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="12">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="136" mass="15467" checksum="4B423FA645232DC5" modified="2012-09-05" version="1" fragment="single">SYTLTIPATSPFTFDDNNVIYSDLESARSANVWTYPHNQLELNKCRVFKDLWDRGMFMGDGLRFGGHFLVYPGDPLRYHSHYTVTVLEDTSSVIKPLDIVALGRLGTTVKKVHLLTSYNNKTEKVDYISLEWAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDS2</accession>
    <name>I4YDS2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_37628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957916.1">
        <property type="nucleotide sequence ID" value="XM_006957854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDS2"/>
    <dbReference type="FunCoup" id="I4YDS2">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDS2"/>
    <dbReference type="GeneID" id="18472028"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37628"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015775_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDS2"/>
    <dbReference type="OMA" id="PGIVDMT"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="567"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="67798" checksum="D133D612F8ACA23A" modified="2012-09-05" version="1">MFYSDVILSKRGPLARIWIAAHIEKKLSKKEAINTDIGESVDVILNPEAVEPMALRMSGQLLLGITRIHSRKAKYLLEDVNDALTSLRKAFIPGIGTIDLSEQQLLAPENAITLEEGPAIEDGGLDLEQFQAPISFSLDPLFDINNMNMSVSGISSGDFMGDLSIEAGRREGSVARSDRFSILGSEFNEQGRADKGRQSGATAGAVDDWGMPIDAGRDDFGDFGMDDVPPAGRQADNMEMDLGGAFDGGLDLGFNLDEPLVPAAPSIGRESSPLSSAPPADSQMDMDDSTRNAVEQEAQRQAKRGGGRKRHIVDSRIELGRRGASQSQQRAEEDISKILQDETYLQPSRAYQERLDILQDPLNHFINVNASQGKQMIRVAPPNILNETLNSLYDVPVGCLRKQRDEDEDGPSKRLREDAETGRHESIPFDDDGWNLAGIDVGPADTSAWEGGDQNEDTFQLDDGQGVFDKDVMNEPLMNDEWASLPTGSVSGRSESRAPSRMSTPSLDTPSASQYEAKEGEAPIAMFGRKQTKQDAKQLTKDGYSRTTVKAKEFLKARLTDNQPESHVSFNEISNKANKRAASSFFFEMLVLGTRQQVNLNQESPFSDIKIGAKDKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDT6</accession>
    <name>I4YDT6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_32267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957930.1">
        <property type="nucleotide sequence ID" value="XM_006957868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDT6"/>
    <dbReference type="FunCoup" id="I4YDT6">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDT6"/>
    <dbReference type="GeneID" id="18471451"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32267"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_2_1"/>
    <dbReference type="InParanoid" id="I4YDT6"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="414" mass="44425" checksum="D0B46C0AE61C4D79" modified="2012-09-05" version="1">MSTFGTLFRVTTYGESHCKSVGCIVDGVPPGLPLEDVDIQAQLSRRRPGQSNLTTPRNEADAVQLQSGIEHNVTLGTPIGLLVQNKDQRPHDYSETDLYPRPSHADWTYLGKYGIKASSGGGRSSARETIGRVAAGAIAEKYLKLSHGVEIIAFVSSVGKEHIPYIPTDTDEPISKEFRDIMSTVTREEIDKDTTRCPHKETAERMTERIIKAKEANDSIGGTVTCVIRNCPIGLGEPVFDKLEAKLGHAMLSIPATKSFEIGSGFRGTEVPGSAHNDPFVKSTKGLNGLGTTTNWSGGVQGGISNGEDIYFKIGFKSPATISQAQQTAKYNGDAGVLEARGRHDPCVVPRAVPIVEAMASIVIMDQLLIQNSRTAAASLLPPITTLPPTMVLSQSAMSEIKKEADKNAEQAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE37</accession>
    <name>I4YE37_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957494.1">
        <property type="nucleotide sequence ID" value="XM_006957432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE37"/>
    <dbReference type="FunCoup" id="I4YE37">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="GeneID" id="18473650"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59956"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_0_1"/>
    <dbReference type="InParanoid" id="I4YE37"/>
    <dbReference type="OMA" id="KTHFKIW"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="236" mass="25965" checksum="DE943E448ED84317" modified="2012-09-05" version="1">MQRSFVNYFQKSIINNAKAKQSARVSVIDACTQLKQTDSKRPWSAYELVVVTKKEKGHIPLRGMVELPHDPRKTREVVLVFAEGADAKAAKEAGADIVGGEELVGDLLSGKQALPTKALAHPSLLPQVQKNLARMLGPKGLMPAEKRGTVTTELAKAINEARGKVTWRGDRIGVVRLGVGRIQFDSNQVEENIKKFIDGLRNGMIIDTAPGQPRRLTTIEKIYLSSTQGRAYELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE51</accession>
    <name>I4YE51_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COX5B-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957507.1">
        <property type="nucleotide sequence ID" value="XM_006957445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE51"/>
    <dbReference type="FunCoup" id="I4YE51">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE51"/>
    <dbReference type="GeneID" id="18473655"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59966"/>
    <dbReference type="eggNOG" id="KOG3352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091071_2_0_1"/>
    <dbReference type="InParanoid" id="I4YE51"/>
    <dbReference type="OMA" id="FDMEPLQ"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="150" mass="16362" checksum="474110290F4E688C" modified="2012-09-05" version="1">MISQLRSAVSRNIATVSRQSIRPSIVSRRNYSAAPPSIYGPGAEDGTVPTDEDQATGIERMELLAKAQGSELFDMQPLKVDRMGTMKDPIIVPSLTPIRIVGSTGYPVDSNDTVWLTLDVRVNDGIGRCPESGVVYKLDYQGAPLDEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEC3</accession>
    <name>I4YEC3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957571.1">
        <property type="nucleotide sequence ID" value="XM_006957509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEC3"/>
    <dbReference type="STRING" id="671144.I4YEC3"/>
    <dbReference type="GeneID" id="18473681"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60011"/>
    <dbReference type="eggNOG" id="ENOG502SAA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552314_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEC3"/>
    <dbReference type="OMA" id="CAFTKKI"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54149" checksum="F9811E3FAFE0C020" modified="2012-09-05" version="1">MDKLNNLGIDNNTKALLAAIIALQLLHLFKRTDSVVHPIILSNQSEASPVRNQNQSAIYRNSSLGNLPLVERPAAKARGAADLLELSDNNARMLIQSQPYTPSTLIDQAVKAISSISKHTTLLKSKTSTILIATQDVHIAVLIELGALLIGMQTAHINANDNIAAALTKFEEHGAQITAIVADDKLGILPRHLNDVLCVFTKSIPPNVGLNYVKFEVDALVEPLSIDKNNREPSNTISYVLSDDTVYKMDNKNITAGVYSILSTIPLAKKPAHNDTIVTDEPLSTALGRTLLYTSIFSGCSYFCIPQDAALPLSPVPQYLFVSGKHLSLLAHDLSSIAINKWWYKFSRRQALAADAAGQIPPPSNWGVFRRVRDTIGLNNGLKYVVSTDGEINDSTVTDLRISLSVPIVKAFKDPRSSSFVFSRIAYDTLKNGGLGPPTYAIEVRLADGGLDEFSGRLQFRGPCVLEGHGDQFSDSTNQSFMKILESGSFELIKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YED7</accession>
    <name>I4YED7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957584.1">
        <property type="nucleotide sequence ID" value="XM_006957522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YED7"/>
    <dbReference type="FunCoup" id="I4YED7">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YED7"/>
    <dbReference type="GeneID" id="18473686"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60017"/>
    <dbReference type="eggNOG" id="KOG2241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="InParanoid" id="I4YED7"/>
    <dbReference type="OMA" id="VQAFMSH"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="8">
        <location>
            <begin position="144"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="314" mass="34282" checksum="DB3B99062185E94A" modified="2012-09-05" version="1">MDLAQFEKEIATKTFLKGQLYSSDDLEMYKNLHSAIAPLQAAQLHAFPNTVRYFSLIQKLEPARKLGLEQLTFDYSTFPKPVRVADAPKEKKPKKDAAPVNKEAPAGTSKAGAEGAAAKKEGKKDKPKKEKAPPAPPAPVLPPSPSMIDLRVGKIVKVEKHPDADSLYVEQIDLGTETRTVVSGLVKYVPIEEMQDKMVVAICNLKPASMRGIKSFAMVLCATSSDGKDGGVEFVNPPEGSAPGDRIFFEGYEDTKPEEQLNPKKKVFETIQPGFRTLDTLEACWINPETSKPHLIKTSKGICKAGKFANATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF98</accession>
    <name>I4YF98_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_27897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957306.1">
        <property type="nucleotide sequence ID" value="XM_006957244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF98"/>
    <dbReference type="FunCoup" id="I4YF98">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF98"/>
    <dbReference type="GeneID" id="18471016"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27897"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF98"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="34766" checksum="998527FBF2FB8CB4" modified="2012-09-05" version="1">MTFSFGFQLDDDNQGVTTNTTTIDTNVDESLHPWTDIKVEDLISQLPPLLSYSSVDIPHSSITPIARRDLFDARFQLIDADEDQAIISGDSDLIPGKYEGGLKTWECSVDLVQHLHQCQYDFREKKLLEIGCGTSLPSLYAYRSMLEQSGPKNAVIHFQDYNLQTIQLVTFPNIFLTWYITQFNKGPEGEIEINETIIEQFKQHLRDVNIELRFSYGAWKAINEHYDYIFTSETVYRTASIPTLVELIESSTHKDTITLIASKSVYFGVGGGVREFSDYVTSKGHSVDPAWSSKGSGVVRHILSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFA2</accession>
    <name>I4YFA2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957310.1">
        <property type="nucleotide sequence ID" value="XM_006957248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFA2"/>
    <dbReference type="STRING" id="671144.I4YFA2"/>
    <dbReference type="GeneID" id="18473595"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59866"/>
    <dbReference type="eggNOG" id="KOG4191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537714_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFA2"/>
    <dbReference type="OMA" id="DREYLMQ"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="505" mass="55926" checksum="E1737089CF6FC69D" modified="2012-09-05" version="1">MVRGLKEFSEPLEAVEDKVNNSTTRADIERISSRLSEYSREASAILAKLENDSKAIDEHYSGLKLEALKKRKREDEESSTAQASATTSSSTPTGQNLTQTTLNPFKLKIQTNKPKRTLSFDLPSTSQLPRPARTKPLPPTPKTQDIVNDDFVDKKPASQTQISTFYSSIEPYLRPLGEDDLMFLSAKGDEVTPYTIPPLGRPYLSVWEAEDAGLPFTSIDQPSIPPLPRPTLTAQDMSDDSLINEDFSLGALSERLVSALLPINKPTEEYTNETQDVTTDKVAVGMLDDSLRRELISIGILNEGDLGPTQPIDDEISVQLAHLQNILQVQSQMNTSRRLHLLGRAKERMAAQEYITLLTDVEKTIEAGWAKRQKQLTRIKKKKTEKAAQIAQQQAAKKTGKLPPPTSGSSTPITQSNSNADLMSDLGESVKRAIECRNLLIQNVGKPLMQENELHPGKYFGLKEQEAGAIVANIRDSVDISEKEPSMAPEEEDEDIPIVEGVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFC5</accession>
    <name>I4YFC5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957332.1">
        <property type="nucleotide sequence ID" value="XM_006957270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFC5"/>
    <dbReference type="STRING" id="671144.I4YFC5"/>
    <dbReference type="GeneID" id="18472863"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56832"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027723_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFC5"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="433" mass="47813" checksum="AED8C40ACA149885" modified="2012-09-05" version="1">MRLQYPSTQSIWFTRFFTSTTSSDYSSRASESTAKRAHLCAALKSDKNEDLNLISSIQEYLPHLLALEKSALNDSIVTIADDFFLWTVPSQLSPKGKSTSSSSLTFEVVHVLHVHALALFNHAQGLADKVGSYDSNPLLPDSNRKECEDILQSAVSALNLAAGMFKYISDTAIDNYEGARDADTPILNREYNIGLSKLSLAVSQSLAIRKLMSPHHAYTLQNPGPPLPKAHPSPQILLKLHLDTSSLYNSSRMMLKSSIKSTLRVQHVDLPAELKAHTKRREKFHAGVAKKWLGVDAANSGHTGLAIAWLKAASEELAESVTSSSSEKLKILSKSIRKARDERKNELDVELSSIDTYFKAYKQLNDTVHFQDIPPSQSLLSQIPSGRSLVAATPYTPPPVAWVLQDTPEEKENTSDATTRSTNTQYALQGKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFK5</accession>
    <name>I4YFK5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957405.1">
        <property type="nucleotide sequence ID" value="XM_006957343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFK5"/>
    <dbReference type="GeneID" id="18471390"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31909"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_5_0_1"/>
    <dbReference type="InParanoid" id="I4YFK5"/>
    <dbReference type="OMA" id="HECFRTR"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="118"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="615" mass="70250" checksum="ABACC718CB78264C" modified="2012-09-05" version="1">MSAIERLSVPQQKLHKHDSSSTLNLPLHDSVEVQEGEFHEPTQEEGSKSNLIVDTTEANRAYTASPSGTYPERRGSNMDSPIGRDGKGGVEDVGLFQGQYYPSYMHAVRNTKKGPSGRTIILCLDGTGDQFDGDNSNVVRFFRCLKKDEPSKQLVYYQAGLGTYVTTRSANPITTKLSEIGDMTIGSGLGHHIRDAYAFLMENYTQGDKICMVGFSRGAYSARGLAGMLQKVGLLPKGNREQIPFAYRMYKDNSDDGWKMSSLFKETFSIKVNIHWIGAWDSVSSIGFIPRDLPFHKSNNAVKQFCHAVALDEHRAKFKAGHWVRSEEMEVREGLLQRRKEKLRPTFGDINEVEEEDIAHETHDTEEDSKKAVERKRKEIMKTIRQLRKHTQKSKGEDDSSVDAFNPEIQAQFEMLFELQDKEDLSETKVKEVFFMGCHADVGGGAVPNDTRHSLARIPLRWMLRQAFKCDTGLLFQTDLLDYYGLDLKTLYPFVTRRPPAVENPPEGYPELPTQDNPRRTFSEAQEDYYDSLCPHHDYLNLSKGWWILELWPLREIYQDEKGKYRKRLAPNLGHHRTIRGTNTKFHRSVAIRQKRIGYDIKARMVDSPTSHWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN0</accession>
    <name>I4YFN0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957429.1">
        <property type="nucleotide sequence ID" value="XM_006957367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFN0"/>
    <dbReference type="GeneID" id="18473636"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59934"/>
    <dbReference type="eggNOG" id="ENOG502SI5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653858_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFN0"/>
    <dbReference type="OMA" id="GIGWNWR"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="237"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="390" mass="43980" checksum="D1588F0B490FEAC6" modified="2012-09-05" version="1">MTSIIRQPIPQLPELDTTKPLAPAYFQILPYVFILSSLLFLPIQLRRYIGLPVTIAVTIYPLVYLRQPDAVTAYLIGNAQIYATILAGSLLTVEIEKTLVKLDKEGNEKAPPVGLWDRFKFYADLLSNPRGIHWKWSRKIDKQGIEEESTKSKWVFIRDRLPALFIYILILDAFETYLHTPPYDILTIRPISAQPATLQVFHLIFFALVAMSAISVSNILASIVTVAIGLSKPKDWPRFFNMKESWSIARLWSMGWHSVFKKTITFYGNAISSVFPRFAQMPIKVLIGFSLTGLSHAMGAYIMAGLGKGQFYFFVIQTVGIVAEYVLLGNTFTGEPPSTSRKWFGYLYTAGFVGITSRPFLDEFIVSGLCTDDIIPISITRGILTGQWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFR4</accession>
    <name>I4YFR4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956860.1">
        <property type="nucleotide sequence ID" value="XM_006956798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFR4"/>
    <dbReference type="FunCoup" id="I4YFR4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFR4"/>
    <dbReference type="GeneID" id="18473462"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59625"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_1"/>
    <dbReference type="InParanoid" id="I4YFR4"/>
    <dbReference type="OMA" id="TCHIGAA"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="423" mass="46141" checksum="AB3262D64BE23B5F" modified="2012-09-05" version="1">MSDFVMERGEGSYIYTDKKKFLDFSSGIGVTNLGHCHPVVTEAVINQVKTITHAQCTLGFCRPYVELVEKLLQIMPDESLDTMLFLNSGSEAIDNAIKVARKATGRQNVICMQGAFHGRTYGSSALSRSKTVYAHEVGPVISGVFATTLPYWHQLGVPAETSEDAVVERAIFDLDALFLQQCAPQDTAAIFIEPVIGEGGYIPVPNSYMKALRERCDKYGILLVIDEIQSGFGRTGAMFAIEHSGVRPDVMTFAKGVANGFPLSGIVASGSIMHKMGPGMQGGTYSGNAVACAAGLAVHKVFKEEDIIGNVKSRSAELFNMLNELKQSEEGRKLIADVRGHGLMVGIEFKSSNLAIPAEKNITFRGVGEKIHKKCIEKGLFILTTSIYDVIRFIPPLNISKAEMEQGCKIFKQSFFETAPEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV1</accession>
    <name>I4YFV1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MBOAT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_53703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956894.1">
        <property type="nucleotide sequence ID" value="XM_006956832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFV1"/>
    <dbReference type="FunCoup" id="I4YFV1">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFV1"/>
    <dbReference type="GeneID" id="18472628"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53703"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="InParanoid" id="I4YFV1"/>
    <dbReference type="OMA" id="GWHRSYN"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="598" mass="69602" checksum="F2DCE428B08B769E" modified="2012-09-05" version="1">MKASDAKYLVTAPSAGLSLALLNNQRQLLTSGKSSQTISSKRTRIELQKQKRNMNKLNMNTKIPSCKQSMNLLQSSQTNKSRWGSNEFKIYYLVFIIMIPIIFYIPIDISNIRHINYSRYSGRLANGWLFNRKIDLTDQQYKSFRNNLRQLVCISLIHVLISKLIKKINKLTELNCDWILCVAVLLGLHSYHFVFPLAISIASYALSKFLAGYKYFYVFIWLFNISTLVAIEYYNGISFALIHPSLGYLNSSKGLVRWYVFYKMTTLRNISFALDLHWMRMSYGRVIKPLPMRSLTYSERKNTSLEEQDYGLFNFLYYVFYPPLYLAGPIMTYNDFIHQSYLHFNRPTMDYTLKYALRCLSTFLTLEISLHFIYVVAIKNTGAWRNDTPSQIALIGFWNLIVVWLKLLIPWRFFRLWSLADGIECPENMIRCVANNYSTTGFWRSWHRSFNLWIIRYLYVPLGGAKYAALITPVIFVFVALWHDLNWRLLVWGGLASGIILPELLATYLLPPHLYNHRWWYRHLCAVGGVLNILALMGANLVGFVLGIRNTKDFLIDLVCTAAGWKFLAVALPSLFVGVQVMFELREAEKRKGIYLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV2</accession>
    <name>I4YFV2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956895.1">
        <property type="nucleotide sequence ID" value="XM_006956833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFV2"/>
    <dbReference type="GeneID" id="18475287"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67738"/>
    <dbReference type="HOGENOM" id="CLU_2930562_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFV2"/>
    <dbReference type="OMA" id="CQSNCGA"/>
    <dbReference type="OrthoDB" id="2602657at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6084" checksum="87C13AE4BA83AD9A" modified="2012-09-05" version="1">MTKCNTDCSSCGPKETATCKCAPGTCTCADCHNSAHHKECSCGGSGDNCECTRAGKACTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-05-03" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV9</accession>
    <name>I4YFV9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956902.1">
        <property type="nucleotide sequence ID" value="XM_006956840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFV9"/>
    <dbReference type="GeneID" id="18472821"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56546"/>
    <dbReference type="HOGENOM" id="CLU_767692_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFV9"/>
    <dbReference type="OMA" id="EAECRIN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="381" mass="45138" checksum="B8F2F85587208239" modified="2012-09-05" version="1">MLLIKTKTDITNLNKIKKFLLEIYNHIKDPTKPNFNNLLNDFIFNCNLHLKTLAKLRHRYNLLNSQYLDLKSISHNYINDLITISKRLDGIHLPVTSTNSPFDHNPYQSLSDYLSFDDYNDFIRGIQLDLDNLQSCLQSSKNLMRCLDIVVHQQYPSYSELVELSQEYTFINQWLDIYKSTIEPSIDEHLRSVESHWNQLIDAESNDLTEQEEIILTQDVEELTLIVNESQETLAEAEIMQKRSDNLQANFERQVNFIQDQLNEQQSINVTINESIELENDIEIYFDKLSNDIKSRLKSSQELFNRWSNYLRMNEHLSGELKRQEDIRKEIERIRVDANNQIQNLYNHSQIKADKFWRENEAYLPANLVETFRSNLILQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFY5</accession>
    <name>I4YFY5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_43717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956926.1">
        <property type="nucleotide sequence ID" value="XM_006956864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFY5"/>
    <dbReference type="STRING" id="671144.I4YFY5"/>
    <dbReference type="GeneID" id="18472302"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43717"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_6_1"/>
    <dbReference type="InParanoid" id="I4YFY5"/>
    <dbReference type="OMA" id="FNHQLAI"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59987" checksum="449A5367D7D1467B" modified="2012-09-05" version="1" fragment="single">MFGKFRTEFLSNLHTEISNEQPTRVTDSSDTLLPEQPKRGGLVTSGSKHQFKKPSSLGLDKLAAAKREAAKEQDGPSKKLKSDDEPTFKVPSKPSSSSIRTRAPDTPSSGTGLSAEASRKLDEYRRRRNQPAYSSSNNESSDGSSRNRFDDFRKRSNRYQDEEERRRKYERANYTPTPGYRDRGWESTPKANRSRGWDATPSRDVDEGVDVNVDTKEYEDEQLRLDRDWYSIMGEEGGVTGDMEHNPFAMYEDLDKQKESELKTKQRKRMSAKQIQFNADNEAWETNRMVQSGIASRPDLDFDFEDENEAKVHVLVHDLKPPFLDGRMVFTKQLEPINPLRDPTSDLAVFARKGSALVREKRAQAERQKAAAEVASIGGSQLGNILGVKSEDDQVVDEAEKNSARELQEGENAGKGNSQFAGHMKAQNQTTSFAKSKTIKQQRQFLPSFACREELMNTIRENQITVVVGETGSGKTTQLTQFLVEDGYGKAGMIGCTQPRRVAAMSVAKRVSEETETELGKLVGYAIRFEDCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG38</accession>
    <name>I4YG38_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956976.1">
        <property type="nucleotide sequence ID" value="XM_006956914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG38"/>
    <dbReference type="STRING" id="671144.I4YG38"/>
    <dbReference type="GeneID" id="18473501"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59688"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009058_1_1_1"/>
    <dbReference type="InParanoid" id="I4YG38"/>
    <dbReference type="OMA" id="PLESCIV"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="167"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="545" mass="62357" checksum="98D3519D44519F35" modified="2012-09-05" version="1">MEDLGSPKQTMPSEVVVGPLETANDSNSNPWSPWATYSANTQATTSSYLDGLVPDENFADEFEQQWMAHTSGSDADMTIAALQKLLFRTELPARSVEKILGLTVRGRVVQKAEFKFALALAAYAQQGQELIIDVVTMAKPPIPYPKIVDMPEGVSQNDDSWTVATQAEMTETVIIRLEGEKEGFLFTHHNYNIESSRGDVSRRFSDFVWLHDCLLVRYPFRNIPNLPPKRLTVSGHSLSTDANFLETRRRGLQRYMNFILNHPILKTDGLVLTFLETPSLESWRKNTKVALEEESQMLNRVKAMSIPVDLDERIDKLKVRIPNLIDNWTTLCAQFERILKRNETDARDYITLSMTMGTVIESDSQSWGRGQGDTVSDNLTLAKTGLEEYASVAYDRTLQMSLQALEASRYVRDLYIAYLSLLSRYDKLTPHSVEKLKKNMERSQRKIQTLAQALEREGDLKQRRKFENEIHTQNTIIESAQVQIQHALTKRQFARYCVWTELIQLQHQETPLVYNVIRTLINSHIQKYNDSGSTWKALKEKLTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGI1</accession>
    <name>I4YGI1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957106.1">
        <property type="nucleotide sequence ID" value="XM_006957044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGI1"/>
    <dbReference type="STRING" id="671144.I4YGI1"/>
    <dbReference type="GeneID" id="18473542"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59761"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGI1"/>
    <dbReference type="OMA" id="RACNAYS"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="492" mass="53568" checksum="6FB82D02ED267628" modified="2012-09-05" version="1">MSSLGRAQIHNDAIIPPVKAVSTKYNTVTTDVIDKLRSALGEENVITDKEVIQGSVNSQWSYLVDLPPSVIVTPSNTEDVVKIVNVARDNHIPIISRSAGTSLEGHCSAESGGIMIDFEQRMANVLEVYPDDLQVRVQPGVKWVELNEHLEEIGLNLFFPLDPSPGAAIGGMLSTGCSGTNACMYGTARGEWFVNITVVMPNGKVMKTRQRAKKSSAGIDMTKLFVGAEGTLGVITELTLRLAPKVPTSVAVAPFDSIEDAAKGVAKVIQSGISVNCAELLDDLAIIANNNSGSTYKKYEEKPHIFFKFAGTQAHMAEDAERTAAIVKEFGSKLEYAENDDEAKNLWEARKWGLANIASMVPNSRIWTTDVCVPQSKLPTLVKQIKSDAVEAGIYAPLLSHCADGNAHFLLAFKDDKEREVVEHLVEKMVERAQALDGTCTGEHSVGVGKKHHLVHELGEETVRALWTLKNAFDPDNIMNPGKLYPDIDTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGL2</accession>
    <name>I4YGL2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_44067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957137.1">
        <property type="nucleotide sequence ID" value="XM_006957075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGL2"/>
    <dbReference type="FunCoup" id="I4YGL2">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGL2"/>
    <dbReference type="GeneID" id="18472317"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44067"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_1"/>
    <dbReference type="InParanoid" id="I4YGL2"/>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="22012" checksum="4F31CB8601361219" modified="2012-09-05" version="1">MVRSAQVERNTGETQIKVNLTIDAVFNKQKQVIDVHTGIGFLDHMYSALAKHGGMSLEMHCKGDLWIDDHHTAEDSALALGTAFKQALGDIKGIKRYGSAYAPLDEALSRAVLDISGRSYCVAELDLKREKIGDLSCEMIPHIFHSFADTAAITLHVDCLRGNNDHHRSESAFKALALAIKDAISYTGSNEIPSTKGVLAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGP6</accession>
    <name>I4YGP6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_67452</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956537.1">
        <property type="nucleotide sequence ID" value="XM_006956475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGP6"/>
    <dbReference type="FunCoup" id="I4YGP6">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGP6"/>
    <dbReference type="GeneID" id="18475256"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67452"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_1_1_1"/>
    <dbReference type="InParanoid" id="I4YGP6"/>
    <dbReference type="OMA" id="WYNKWSQ"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="257"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM23138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38509" checksum="3999133912BB6BAE" modified="2012-09-05" version="1">MSTSQPKAKRLVQPARRQVEPGQLKKPEIAQTGFTYNIWYNKWAGGDYEDSTNTKEHAQTRLDLTKDSGYTRADASGAKTYCLFFARGCCPLGAQCQYLHRLPRPQNILHDLSRDVFGREKHASYRDDMSGVGSFSRQNTTLYIGRMAEYGEGRGENQLIKHFGEFGEIEKVRVLHGRGCGFVKFKNECNAQFAKEAMGSQSLDEGETLNVRWATEDPKADAIDEDRKRAAEEGTEKVTKRLAMDTELIHATRQMEALQNGLPPPPPVEYITNGQEEDDEQDDADEVTPVQGHQHSQQPQDKGLLSGTSIQAINKLAQLRASKPTAVAVASKPTNGLGGLAGYGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGR0</accession>
    <name>I4YGR0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_31329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956548.1">
        <property type="nucleotide sequence ID" value="XM_006956486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGR0"/>
    <dbReference type="STRING" id="671144.I4YGR0"/>
    <dbReference type="GeneID" id="18471282"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31329"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_3_1"/>
    <dbReference type="InParanoid" id="I4YGR0"/>
    <dbReference type="OMA" id="MXAFSGG"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="10672" checksum="06AC3F515577E4FD" modified="2012-09-05" version="1">METLGLCALGLTGGMFIASRLRAKTVASKWAIGGFQAKMDKKEALQILGLREQLANTQRIKHAHRTIMLANHPDKGGSPFLASKINEAKDLLEKQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGW3</accession>
    <name>I4YGW3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956598.1">
        <property type="nucleotide sequence ID" value="XM_006956536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGW3"/>
    <dbReference type="FunCoup" id="I4YGW3">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGW3"/>
    <dbReference type="GeneID" id="18471288"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31362"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_0_2_1"/>
    <dbReference type="InParanoid" id="I4YGW3"/>
    <dbReference type="OMA" id="MDMHDMH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="189" mass="20705" checksum="7CB58909205E212E" modified="2012-09-05" version="1">MEMSGMDMGGMDMGDGGMDMNMSCSSSMLWNWNIMNICPVSDQWHIKSHGAFAGTVIGVFFIVVAVETVRRFGREYDRKIVNDYRKSQADAGNVAPDVDAKGDIGPAPVLVGTGQLKPFRPTFTQQLIRSLVYFVQFSATYIVMLIAMTFNGYLLFAIFFGGGFGYLVSSWDTVGLVEDTDKSSSGCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHD2</accession>
    <name>I4YHD2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956755.1">
        <property type="nucleotide sequence ID" value="XM_006956693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHD2"/>
    <dbReference type="FunCoup" id="I4YHD2">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHD2"/>
    <dbReference type="GeneID" id="18474784"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62741"/>
    <dbReference type="HOGENOM" id="CLU_101473_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHD2"/>
    <dbReference type="OMA" id="REYDSCF"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="85" mass="9969" checksum="D7C518AB37847C35" modified="2012-09-05" version="1">MTSESEFGKSASLDSSCNDFKNAYDRCFNQWFDKYLEHYSQQRIEQSTETYEKNCGGLFKKYSECLEKSIESKPALKELLDNNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHK4</accession>
    <name>I4YHK4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid/diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956819.1">
        <property type="nucleotide sequence ID" value="XM_006956757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHK4"/>
    <dbReference type="FunCoup" id="I4YHK4">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHK4"/>
    <dbReference type="GeneID" id="18473456"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59615"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016065_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHK4"/>
    <dbReference type="OMA" id="FYFLKWV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="536" mass="60666" checksum="764B1026166D9B2F" modified="2012-09-05" version="1">MLFPGVITTGLESWSTDADSLSFFRQRIWGTHTMFKSIFADKNEWIRQISLDSETGLDPPGVRVRPAQGLDAASMFMQGYWVWRPIIENLACINYDTNNLEMAAYDWRLAYSNLENRDHYFTRVKSRIEMNKKIHGKKTTLVSHSMGGTVLMYFMKWVEAEGYGGGGNTWVEDHIENLINISGTLLGVPKAMTALLSGEMKDTVELNPAGAYALEKFFSKEERADLFRSWFGIAGMWMKGGDAVWGNSTYAPDDPENTTDTYGRFLSIRDNYVMDPNQNKTLSRHNYTITDANNYVLTNTPKVWQKMMHNNYSYGIEIDEKKLDENNYDPTKWSNPLESRLPNAPSMSIYCIYGVGKPTERSYYYTEGPKTHQGLQSDMEVGKCEADDCDKTEESNDDLPLTAQNAIDNDLNLPEENPQVSNGVKFGQGDGTVSLMSLGSMCSNGWRRPDRRYNPGNSRIVSYEIDHKPDSMDLRGGDHTGDHVDILGSTPLNELILKIAAGKGNEIQDHFVSNIREISDRIDWDLVNHASDKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHT5</accession>
    <name>I4YHT5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956204.1">
        <property type="nucleotide sequence ID" value="XM_006956142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHT5"/>
    <dbReference type="GeneID" id="18471238"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31048"/>
    <dbReference type="eggNOG" id="ENOG502S4MU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053189_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHT5"/>
    <dbReference type="OMA" id="VACIHRR"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF1">
        <property type="entry name" value="QUEUOSINE SALVAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="377" mass="42385" checksum="E2B815F5B8354E33" modified="2012-09-05" version="1">MTSNGLIQSVRESGRYVVDNGLLNISDDAIDIVLNRINNETFEKLSTNHGYKLPLKFSNISEELSVFGLLSALNFASGYRETLHKYTGKGAFDNIKRFVLGLFLSKDSGTLTVDGLEGFTNEFTIELLDIKPFNEKPHPTLPGVVVGERDDVAFEFVNLVTSTLNDIGRTLRQLNKASFGDYLFDLFSQASGADNIVNDLVTRFESFRDEHTVKVGADNVQIKLYKKALILVETISIELRGRSDVPFELPSVELPIFSDNVIPSMLLHWGIIEIPESSSHFDETTKRAFKHDEEEYKAIIDGLEQEQQRDLGAVVQGPSLSSSQAALIRSAAVEAVRRMATKSPHSEVEFDAYIWSVSKQDHYRRLVRFSEQNTVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU8</accession>
    <name>I4YHU8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">mRNA export factor elf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_59252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956217.1">
        <property type="nucleotide sequence ID" value="XM_006956155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHU8"/>
    <dbReference type="FunCoup" id="I4YHU8">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHU8"/>
    <dbReference type="GeneID" id="18473251"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59252"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHU8"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="325"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="564"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="693"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="871"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="104945" checksum="B8B8FFFB49B86326" modified="2012-09-05" version="1">MTLLENVWSVTNSSSAKWKSKSTGLQIITKLVKSGGPLWRARFSEHLGEMVPHLETAMHDTKSEVANAAKKCSLAVCSLLQNPDILPHVPALVSAMQSPTAVSALIKQLSSTTFVAEVDGPCLAVLVPLLSRALKEKSMETIRMTVIVIGNLVKLVRDPRVAARYLGEVFPGVTNIKEGAAFPEVRAFAATTHQIMVSAGASSSNPESNRSRPEEIIHACEVFNRLLAAEGVATIVAAPKIEEDDLIATSLKYVSDMVVDLAYDRDFDKSKWVDLTIAPYIQHYLQGKREEANKVAEEALEVYLEIDKKANANTLNEYEDDGEELCRTDFSLAYGGLLLLNHTTLRIVRGRRYGICAGNGKGKSTLLKALRDGKVEGYPTQDQLRTIMVEHALQGEDASLPIGDFVASDPNLKNVSRERVTEALESVGFSAEKQKDPVGSLSGGWKMKLELGRAMLIGADVLLLDEPTNHLDVPSVQWLENWLVENNTTILTVSHDSGFLDAVCTDIVHYEDRRLVYYKGNLSQFVARVPAAQAYYTLEATTIKFTFPPPGSLMGVRSNTRAIMKLKDCVFAYPNTPRPQLNGVSCALSLSSRVGILGPNGAGKSTLIKLITGETTPQSGSVYKHPNLRVGYVAQHAFHHIEQHLEKTPIGYIQWRYAQGYDREVLEKETRVLTEEDQKMFDTPIIGKTGEKRFLERIMGRQKLKKSYQYEIKWKGLAHKSNVWLPRDQLIEAGFSKLVQQFDDFEASREGAGQRENKAELIRKMLEDLGLDGDIAQYNEISGLSGGQKVKVVVAAAMYNNPQILILDEPTNFLDRESVGGLATAINSWTGAVCVISHNLEFVHAVCPEIWNVDAGVLTIEGKAAQIEDVEEKKVPKPGSRAASRAASAAASAANSAATSATEDSASSVPKPKKKKKMSRNEVKAQEERRRLRTLRFLSDSTIKEREPDTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI12</accession>
    <name>I4YI12_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_67245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956275.1">
        <property type="nucleotide sequence ID" value="XM_006956213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI12"/>
    <dbReference type="STRING" id="671144.I4YI12"/>
    <dbReference type="GeneID" id="18475227"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67245"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_8_0_1"/>
    <dbReference type="InParanoid" id="I4YI12"/>
    <dbReference type="OMA" id="HNAISYW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="139" mass="15993" checksum="93D09924C162670D" modified="2012-09-05" version="1">MKNRTLGLIKPQLAGNKTIIDNVEAEIRRHGLEIIATKHFKPSKSQLERFYADHKGKFFYDRLILTMGSGDVRAYILEGENVITKWRELIGPTKLYLAKYSHPDTFRSKFGLSDTRNGFHGSGNENEAINEINVMFDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIE1</accession>
    <name>I4YIE1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF654-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956398.1">
        <property type="nucleotide sequence ID" value="XM_006956336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIE1"/>
    <dbReference type="FunCoup" id="I4YIE1">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIE1"/>
    <dbReference type="GeneID" id="18475244"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67351"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008321_2_0_1"/>
    <dbReference type="InParanoid" id="I4YIE1"/>
    <dbReference type="OMA" id="IWGKMPP"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="745" mass="83489" checksum="8994B3A597335B9E" modified="2012-09-05" version="1">MSNARRLRQQRELESLKSSTPDLETPEDEVAEEKPSKVGNPFAALGAEEDNNSEDEEEEGEEEEDASTLTPTAPAAKKKNKNKKKKKSKGVQQAASAQPPQQPVDDKTYTSNRQAKLARKKQRGLNEIDQALQELNIKYPEQQQTTQTSDTKQNSTISTLKAFLGIDPKQLDASAEMKKMFGAKVVSSATSMNSYGMGRQGRNQRAQAAFMKAMPRSHLAKYKPTWPPPTVAKLDGIGMRTLTLDEMKDWRVRHNLDDSFNLGGSGNSGDGNWWTFVHEPQYKSVQRQFLDATGSFDPNTLMALLQVYPYHVDTLNQVSEVFRMQGDNSNASDFTERALFAIERAFPTNFNVLSGQCRLDFDRVENRSIWLALTRLINHLCMKGCWRTAFEYAKLMLSLDPLTDPYGALNWIDFLAVKAGQHDWIIRLAKEWPYNNTTNSGVVDCAILPGVAYAKALAVYYKEKPSKQLDETVNAFEEAISEHPIVLEQLRDNGLITLSQSRNEKINQTIKANEEHYAKHAGAYHARNIALAKVYYAHSHPLYRDPNIPLQEIINRAIDNLEMTREEQVKKAEQNIIRKSLKVYKFPENVARHVIINNLTDAKQDIPQVFSEGDAFDPVRPSTSASGYNDAYFTGVRTRGGPSDSAGPAAGGIMSFIESLLRGEFNVNDLGRMDPNMRVVLEDQINELQQAGMGGMPGGFGEDEPSEESESEEESDTEQSDPSLVERMSRMIGLNRGNDNDDNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ4</accession>
    <name>I4YIJ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_35433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956449.1">
        <property type="nucleotide sequence ID" value="XM_006956387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ4"/>
    <dbReference type="FunCoup" id="I4YIJ4">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIJ4"/>
    <dbReference type="GeneID" id="18471914"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35433"/>
    <dbReference type="eggNOG" id="ENOG502QQ5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002415_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIJ4"/>
    <dbReference type="OMA" id="DRSNCKR"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="2">
        <location>
            <begin position="341"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="1">
        <location>
            <begin position="445"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="2">
        <location>
            <begin position="659"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="1">
        <location>
            <begin position="775"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="4">
        <location>
            <begin position="974"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127617" checksum="1DA7809A3658BF5B" modified="2012-09-05" version="1">MPLAQLSTAIIPTTLKNAFTFYKAPEEHRVRLKDVVGNRDKHLRGEHTVRVGGFSTAKINPTIQSFCLPETVSSKPLTVPILFNNTEPLVLAYSITPLLPDGSLGEEREVEIQGRELEKNKYITGYTDDDSDDFFDPNHDFYAHQSLDELALLPRGHGVAAPPRLQKTQNIRYLPLTSASALPPPPFVVKLKHVVDKNSELDARIARTEAVIVGCPSAGFASEDILGGDRCVGDKVGFQLGVRSAGGASVAWYSRGPGSHSDVRKLDSIGSTAYTTSAPHARAVSTTTSIPINVTLDKSGDYELELASLEDYFGNNPYPSLYESGLEQSSPIVQYHSHSLPLVSFSGCSAEDPVRLLEGSKSTLRVTVRGVEDSEGSVDVKIKFFDNPDLSSTPGSDIINVHIPAGQPYADIGVSKSGYYKIQEVNGKYCGGVTQMPDVCGVKSVPKPTIDMDIKTIEDCSGEVGIHALMTLTGEAPFKLSYMVEFGDEQKRVEKKIYSSRDELSLTPEREGKYKYTFLSLTDRNYKDIPMGDKGKGITATQVVHPLAGAQFAEKKNKRTVWSCEGNEVDVDIEFKGSGPWNLEFQTTGTSASSITKPVTYHENNIRDRQHTIKVPIPDEIDRLGGQFMISLVSVEDSRRCKKVLAQNDYSVQVQRVKPTARLFGTDRATILDGQTANIPVRLTGEGPWKIGYNHQGESRTVTTDKRETDLIVDSEGLYELVGIHDSHCPGTIIENEDKFYLDFIPRPSITLGESTLSSRKPRKGALHHTLAPVCKGDDSSIHLAITGEPPFEISYQHREGSLVEEERMASVRHSPNVNLDTEVAGTHKYLFSAVGDANYGLKDNGKDYVEIEQLVVERPYAVFKNSPRISYCLGDVLSPRPHEHNPVIELHGTAPWDLELEVSEETGTTSPRRVRVPGIRTPEWEVDLAPLRLNSFGTHKITIVDVHDASDCVAFDEDTQSKKTSVVDVAESATVVPVDRFEDVCVGDSMDFQLGGSAPWAVTYEWNGKPQVVKTKSSNFNRIAEDEGLFAITEVSHHSQQCPTNVDIKRIVHPLPSASVSEGNTYIEDIREGDQAEIKFTFVGTPPFTFTYERRENLPRVRHHELGKVLERHTITNVQDYEHSIFSSLEGTYVVSFIQDGYCRYPKDTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIJ8</accession>
    <name>I4YIJ8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_67402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956453.1">
        <property type="nucleotide sequence ID" value="XM_006956391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIJ8"/>
    <dbReference type="FunCoup" id="I4YIJ8">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIJ8"/>
    <dbReference type="GeneID" id="18475249"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67402"/>
    <dbReference type="eggNOG" id="ENOG502S9TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934489_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIJ8"/>
    <dbReference type="OMA" id="HARSTYS"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="83"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="306" mass="35045" checksum="69221C7C8C8CD8C1" modified="2012-09-05" version="1">MSHKLIALPDDCFNERGKATLLNVPRPLCTNQSILVALSATSSKIYELHAIQARNEDRRCWFVDQLVVSDPHLITATPLDPTFILSALLLSIPEYVRNTYSRYDDVIDTLRNTFPESRDLLPLLESDALKSVTDKCCDSKELSEDELVYKFSTEKFMEYIDRKISRCLSVITAERDIKSLEPSPHHLLTPELTLQSYKKNIIDTILYSIPRSLHAQIKERHPMPDLDAHEEKASKEKFKSDTLIRSNKGYDEGKELDNDDKQKKPAKGTRGSEQLKKVDTRKMMKLDGFFAKKPAKTDQKENDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIK4</accession>
    <name>I4YIK4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_59419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956459.1">
        <property type="nucleotide sequence ID" value="XM_006956397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIK4"/>
    <dbReference type="FunCoup" id="I4YIK4">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="GeneID" id="18473342"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59419"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="InParanoid" id="I4YIK4"/>
    <dbReference type="OMA" id="WMMGIAY"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="301"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="570" mass="65231" checksum="72B057B2053BDF16" modified="2012-09-05" version="1">MAVCIPGYTECHTTDERKAASIDKDNWWVAEKYALGIAMGYTAILIIVIIVQYVKYLSFSKRMMRGTSLGFFNRIAAFCRAMHYNRLRLGGFYFPYTFPMLLLSFFFIWTTVWSFAVFPYYRAGIEWGSPPLGVRSGWMALGLIVPVFAMGSRVNPISFLTGISHERLQVYHQYGAQIILFLSVVHTIPFIIEPYQQGYQLGGTKLARFFLKKYYDGTEQFWNGIPPLVALIWIVISSMGYFRKLNYEFFVIQHVVSTIFFLVWMFIHVDVMYPATWHHMFMATGVLIWSWVGRILITFWANEFKWHDAQLHSHADDIVRLRIITPLRWKPAQNIYLRFPTINIIESHPFTISSIPSLDVHSNSNIMQLLLRGKKGITGKLNSKAQSGKQTIPVLIDGPYGGLPTPLDGYSRVLLLSGGTGVNANISILLDLMRKMERSETLIEYIDFIWTIRSTESLDWFSQTFKQLSSYTSFDNLNITIHITGNADVEKELVHDDKFYSFVKGRPDVKSIIRNTSAAAQGGDLAVSVCGPGDFMFDTMNECSSIELKIATGDENLPRRLFAHSESYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ06</accession>
    <name>I4YJ06_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955787.1">
        <property type="nucleotide sequence ID" value="XM_006955725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ06"/>
    <dbReference type="FunCoup" id="I4YJ06">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ06"/>
    <dbReference type="GeneID" id="18475158"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66830"/>
    <dbReference type="eggNOG" id="KOG0798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034504_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ06"/>
    <dbReference type="OMA" id="DSESWPF"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="40618" checksum="6008CBF7D8DF2B19" modified="2012-09-05" version="1">MIKISTKPEDKVKNDFKLLELNDELVKALDDQKLLLFKGDGDEDVVLCTQDNTYSLKNRMHSNSLTMLDESTNKDEYSIAHTFHEILEVQKCSPNIDKIDMLLSHRVLLDPTEVDNNVEERLKYDYDRISSEIQASDKEIRQAFTDRRIVCFNGEYRPVDPECLLRALDVILNTLELVDMSFNKVDKDELADSINKDHNINRDYISTVIGWYMNSDTTLDSQAFVKEIGLSLLKVQSRATAFEKFLDDWKSRSGYELQDQCNLNLLKGYYLIEAGQITYFTTSSLSKNPSKRFQELFKTRQKWFSVDFIPFIRDLGDSKELERMVMKFCRTQTDKDTGMETYTSRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ31</accession>
    <name>I4YJ31_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyltransfersase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_14313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955669.1">
        <property type="nucleotide sequence ID" value="XM_006955607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ31"/>
    <dbReference type="FunCoup" id="I4YJ31">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ31"/>
    <dbReference type="GeneID" id="18470633"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14313"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="InParanoid" id="I4YJ31"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000091">
        <property type="entry name" value="Peptide alpha-N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="159" mass="18682" checksum="5BF8622F22D258FF" modified="2012-09-05" version="1">MSLSYAEYHDERQLSDIMDLIDSELSEPYINMTYRYFLHTWPQLTFLAYDHTKAVGVVVCKQERHKSGLMRGYIAMLSVRSEYRKKGIATKLVRMAIDEMISTGAEEIILETEVDNNTSIAFYKRLGFMREKRLYRFYMNGKDAYRLCLPVSPNEDAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ65</accession>
    <name>I4YJ65_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955841.1">
        <property type="nucleotide sequence ID" value="XM_006955779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ65"/>
    <dbReference type="GeneID" id="18474688"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61835"/>
    <dbReference type="HOGENOM" id="CLU_150838_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ65"/>
    <dbReference type="OMA" id="EESCECC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9601" checksum="DC6EA0A765553460" modified="2012-09-05" version="1">MSANDYYNQGGQQGGYYPPPPPQAYGGQGYAPQQQPYGGGGYAPQQPMYVQPPQQEKKSGGAGSSACCGCCACLAGMCACCLCEDILCLEALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ94</accession>
    <name>I4YJ94_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955868.1">
        <property type="nucleotide sequence ID" value="XM_006955806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ94"/>
    <dbReference type="FunCoup" id="I4YJ94">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJ94"/>
    <dbReference type="GeneID" id="18473152"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59063"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_1_1"/>
    <dbReference type="InParanoid" id="I4YJ94"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="333" mass="37976" checksum="2A857B96A2589A40" modified="2012-09-05" version="1">MSQEVQVSDMTSKDYYADSYSHFGIHEEMLKDTVRTLSYRNAIFSNSEAFKDKVVLDVGAGTGILSMFAAKAGARKVYAIDMSQIADQAKVITQANGFGDTIVVIKDKLENVELPEKVDIIISEWMGYFLLYESMLDTVLDARDKFLKPGGLILPDKVTLYMAAIEDAEYKDEKIGFWDDVYGFDYSCIKDIALREPLVDCVDLKSVVTNPTPIKEIDINTVKKEDLQFQASWKLECTRDDYIHAFLGWFDCSFPTPNGKPVRFSTGPHAKYTHWKQTVFYTKNTISVYEGQQIEGTISVKPNERNPRDLDIVMHYETIEENKQVETVEFKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJD1</accession>
    <name>I4YJD1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_30823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955900.1">
        <property type="nucleotide sequence ID" value="XM_006955838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJD1"/>
    <dbReference type="GeneID" id="18471194"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30823"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="I4YJD1"/>
    <dbReference type="OMA" id="RHRIMIL"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="120"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM24073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="567" mass="63229" checksum="E543936236E2FFA6" modified="2012-09-05" version="1">MDFVDFSDEIQRRPSTLSGLSSTNHHGQNISEHGRSLEKPRRSGSMKPKNLISDSEDGTLAAEEVKEANAVERREEDIEKGDESGAKEEPRTETDPFLVEFTPNDPDNPKNWKTWYKWHCTMLSSLLILNSTLASSIPTSAMPLIMAEFNVDQEVAILQITLFLLGYVIGPTVLAPSSEILGRKPVFIVTLFVYTAVTIGCALAPNITCLLLCRLITGTAAASPLTNSGGVLTDIWTIDKLGIPMSCFSVAPFLGPVLGPILGGFEAQYANVGSSKNWQWVYYTCLIFGFVCFLMVVFLLPETYGPTILEKRVKKLRKEHKDDRYYCSSMKNRPPIGELLKVSLTRPIRLQFTEPIIIFSSIYVSIVYGVLYISFEMFPLVFQGVHHMSVSMSGLSFISIAIGIAFFLVVTIIFDKRFRKVAMQTGKVPPPELRLEPTMWIGSFAFAISLWWFAWTSYDFVPWQAPMAAGIPLGFGIVMIFMSFLNYLASTYVTFSASALASNTIARSIVGAVCPLFVEQMFDGMTIKWAGTLLAAVATVLCIVPFWFYYKGKSLRQRSKFAFNYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE1</accession>
    <name>I4YJE1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHP domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_55935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955909.1">
        <property type="nucleotide sequence ID" value="XM_006955847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJE1"/>
    <dbReference type="FunCoup" id="I4YJE1">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJE1"/>
    <dbReference type="GeneID" id="18472757"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55935"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041468_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJE1"/>
    <dbReference type="OMA" id="ACLTHSL"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="322" mass="35604" checksum="BB497E8BB46CFE10" modified="2012-09-05" version="1">MFADLNIPFIYTENAIANKKKGKTPTNSLQIDRDDSELQWSGINSNDRKSLETRTRMLIHLGYRVLAYEHYVKNFSIASNSNPFPQNRPVFPDLDTRTTSATRSIIQLRRLTIELDEGTAVSSQISQAASSVFSGYDILAVKVVGPNSFNNACLNMAAPSPFAINIIQIDLAANTRLPFFFKRNTAGKAISDGAFFEICYGGALDGSNEYGRRNLIAGVKEIVRVTGGKGIIFSSNVKNALHLRSPYDVINLGTVFGINQATAKEALFDNCKALISNAESRRLFKGIFDTPKIHQAPSKRANTEESTNNNNTKNKKAKRQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJT9</accession>
    <name>I4YJT9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956049.1">
        <property type="nucleotide sequence ID" value="XM_006955987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJT9"/>
    <dbReference type="FunCoup" id="I4YJT9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="GeneID" id="18473203"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59160"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_4_0_1"/>
    <dbReference type="InParanoid" id="I4YJT9"/>
    <dbReference type="OMA" id="DSSANEW"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="523" mass="60243" checksum="18A67C4ADB94A18A" modified="2012-09-05" version="1">MLCYPLRLSGKRKIYWRDDWSDEILPHLTKPEYIHEDFGDESLMYELVDLYFTKVNVSMPLLHRERFLADIPKRKLERGFGSVLIMVCALGSQHMRADDLRVLIPGKENILFLAGYRYYGIAKAKMIDPTMSIASLEDIQAFFLLQVYSQNGVYPKGGWIAHTNAMMLSQDIGLHRKSFHGINNERQREARRRTIWCLFIIDVTNAAAFGKTQVLTERDIDMDLPSADRYGDIHSKNRLSVSYLVSLVQLYKLLSQILRSVYRLKENVNGDDIVMNISDIAALNSSLNKWLNELPVDLRIESCSNGDEEVYQLRSYLKIGFYMVQIYIYKSFLPDPRSFELSYFRITSLVICSNASKSIISIQKKLVLDRENINGTCYSDLLLSWSVFNATIVLILSFCESRKNKDINLDDLEYIQLGIEILRKREARVLLCGRALDMLLQVIRTASLPLDPAFMQAQEEHVEKHQRSGNLNEQGDILFMNLTQFERQGTDFLDDVNLDSILPSLSTGEDWSDVLNAMFNGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJV5</accession>
    <name>I4YJV5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">WALSEDRAFT_59169</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956063.1">
        <property type="nucleotide sequence ID" value="XM_006956001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJV5"/>
    <dbReference type="FunCoup" id="I4YJV5">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJV5"/>
    <dbReference type="GeneID" id="18473206"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59169"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="I4YJV5"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:DNA replication initiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM24247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="726" mass="80960" checksum="BE7333C3F9FC920E" modified="2012-09-05" version="1">MAGMEDVNMNEDSQGPTPPSGIKYLDQLQRISNRLQEELVIDLEDVAGYEDGNALVNSIVGNTRRYVDIFSKAVDKLMPTPTIDISSKDDVLDTIAHQRRQKQSENAEAGMQGFPEQIMRRYNLYFKPKKSAKLLAVRNIRGADVGKLVTVKGIVTRVSEVKPCLKFNAYTCDACGHEIFQEITSKQFTPISDCLSQECRMNQTKGSLHQQTRACRFLAFQEVKIQEMADQVPVGHIPRTMSVHMYGNLARTVNPGDVCHISGIFLPQPYTGFRAMRAGLLQDTYLEAQYVHQLKKQYDEMELTPEIEEKIAELTQDPNLYAKLASSIAPEIYGHDDVKKALLLLLVGGVTKGMGDGMKIRGDINVCLMGDPGVAKSQLLKYISKIAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMEESDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLLGRYNPKISPVDNINLPAALLSRFDILFLILDSPSRESDERLAQHVTHVHMYNEHPKIDHDPVEPLLMRHYIALARQKRPTVPQSVAEYLTGTYVQMRKAQKEDDSGFTYTSARTLLGVLRLSQALSRLRFADVVEAADVDEALRLLDVSKASLYESKDGNRADNDMTSTSKIWRIMRDLRRINAAGKGDADEDELLELNLRDVRDRVLAKGFTEDSLMDTINEYERLDIIQRVAGGTKIRFVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJX8</accession>
    <name>I4YJX8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_26942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956085.1">
        <property type="nucleotide sequence ID" value="XM_006956023.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YJX8">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJX8"/>
    <dbReference type="GeneID" id="18470968"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26942"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJX8"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3368"/>
            <end position="3704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1219"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1743"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2026"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2266"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2459"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2628"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2690"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2746"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2916"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2980"/>
            <end position="3038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3181"/>
            <end position="3200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1228"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1743"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1767"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1784"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2032"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2052"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2091"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2126"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2189"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="2266"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2459"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2479"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2534"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2568"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2585"/>
            <end position="2599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2631"/>
            <end position="2643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2760"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2980"/>
            <end position="2998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="3012"/>
            <end position="3028"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="3671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="3704" mass="414155" checksum="228AFDF831FDCCE0" modified="2012-09-05" version="1">MAPVRPRTSKRTVAAIPESLRGKLDKIEKSKEEDMALYLEEFGEWKWPKGDLYAYVALLNRLDGVLAKITAEFNLRGTPANGSFYGVQEKPFDAYTKRLLNAILRFLKLLIDNCSNRKIFNSVEHLDALIVTTDIEVLSCNLKLILAIQAHHRNALQLDCKALLALAWNWPTTASLSESTVQLPDFNDNVTFQYFDNQSRSIHLEKVSENPLSDLDLHKQTVDQNKIPKDGSNTFELYHRIRAIKAINNNSHRHLLIESRLLALTLFLQLVKESQAQHSLLIYEPTLVPQLTQLLQLPLKDDYLAIQSNAIICLESLSHYKSKVSEVLSCLNAGVNQGLLFTYIRNVTNKLSQSKPSIQLVDLVDSIFSMISHLSTSNSGGQMLVGAGLITLLINLFKVDSSPLICKCLQLLDALLYSYRNALPIFINAHGLTTLVEKIHQRVSKSLENKTEIENNCQNDEDIRITFGKLSIIDSQAMKSSLRSIYRLLTSSGTEGGIRNLIDTTLLQDIHSIIDNRKFFGAAITSFALNIMATFVHNEPTSLSIIQEAKLPGKFYEAIEDHIEPNIDILNVIFNVISACCLNEHGLEEFKQRADKIISKIFDIFSSPSHIKVLGEKENAVNIGQSVDELIRHQPSLKPKVLKAINDQLDKIVNIGGSFNSQEVSHYGLSEVAKYRLLTKDEHSMVDNLPASEKREEPFALKCMDVMARFLESVFTNGSHAKEFLESGGLDKIGHFFSLPCLPYDFSITRASESIAQLGRVLIETKPEVSLTWSLDQMRTNMDATRHIWSELRNQSLFKQMKEISETNYDEANKTFRSLVELYSRVQLVSDMFASIGFLNIRVSNGFFLPKLNEERHLVTMSMIGDLWRSMSWEYFLFNAEENKETDFDWKELETGSKSSNEKYEKNLNILMSNLDPTVSAKNNKNKTEEEKKEEDSDPVKLNYKSLLHLAMYIPETVTPFFQAVIKMFLYRRQSDQTHKKNSVITSKAVAQILVDHISYNGNGDPRPTCAYISSSLKLINLLIFDERTSHNHLQTPLVFSFAQQGGIKLLADRCDEINEELSKQAITDNEIPKSPGEMQQFRMYRILENLMPLLHTFAATRPLLESSQTGPLQLRETDKSSPEYFNANDFLVRVRSIILPAIIKVCKSEWLSKAPIAQPTRLIVQTFLNIIKAEGEVAEPITTQNPLQRQIGGPGSDRFGHLHDLERALTSMRSSPFSRILGEGATPEQGSQQPQSPQEPSSEGQQPPSRGIVDDITRQLSSAPTPDQALVEELISMDFPQLAARVALIDNKDVAQAAEWLVSRPDVVDACREEEKREERKQAEDKEVEMKVDEGNVFPMTDKIDVVKKSLDNSRKGIQDSLPSILLKLVDAHSEIVFDVKDIFKGDKEKPEEHLGIKTLLEEIERLDPNDRTLDSKIFVRWHLISLIISDHQFAQKDNIANQRSRILNMTGKYKDAIINNEYPPKWLGPYMLATAIVLASSETTKPAPEDPTKVEDVQVNIDDIVDDSALQKETRDLFEIAMTTFTRTKDKQFESRTFMAVLHVLALLTRKTNYSKELFASGGLQMLTNIFNESIENAHSSCIFSTILIRNMIEDEALIKTTMHNELLGFFATSSTRGTGGGSKVVDVSTFTKTAASLALRNPKVFMEVVKENCVLVSDKPAGGIFHIKLRSDVIPDLKPNNASGQKDDTEKMNEDVMQLDGQQSSRVISSETLDSVLHFLVSELMRIGKAARMFASKSTEKIGEEKNKEYEKKNEEEKKKSESNQDGQISQPEASVSATPDDGKKDEKDQKDQKDEKDKMPPGALEYYYACFLLQSITEICASYPSAKLNLVMTNKKRQGGGTPFKPKVTFLNFLISELISTPTLSMPTNDEVGRKQRTLAEWAIAVLVSTCTDTSPWSDTKDIANEVVLSRKFVLDVVSKLIKDNTSGVTEEDLNVRYARLTALAEILSRLIDVKPINPVTGKASNVGSLHMAKVMLEKNYVTTLTHALGDIDISFPNSKITIGALLIPLERLTKISIKMAKNKKGDDDDGNNDEDEGLNASEMGSSESEEDGSSDEDEVIEENDPDRAGTPDLYRNSALGMYTGENYEEENDNEDEDMDDEDMEDMEVDFGEDGSGSSDSSNDEEDFDSDDDEGDEMDADGEEADDWIDEEDDGEEVDFDEDAYDEEEALNPIVDSEAVIDAPTPDDEDPESIADPDILDDGLIDDGFSETDDEADEDGIAFRDEINVERAPRIGGIIDGRHDMGEASAIFGSPLLGGGSSRRRMFGGGQSQSILGGGRDRNESDSELPQQPLLVDQAPPSAAPTAQDTSGRRQGAGGQRPGNNNPLLQTIENMFGRNGFQLIEQLLQREAGGLAGVPPGTRVHLELHSPNGPSGPIPIEQLSNLAARRQQVPMSQSAWIMKAVNDLSALPTFSRWYHTSKLFYGATSQERATKLTNHIILMLLPITREALAKQRAEKGEKSKELENPSESEEEKEKKESKNKEVGELHEPEAREEEMREAVPHEAPPIYQQGDVEMSEVATVEPSASAPESNQTSTNAPAQEEAPSGTDAPQEAPADASASGEASGTAQGSGEASTSAPRERVTIKIYGRDVDITDTGIDPSFMEALPDDMRDEVITQHMRETTRASNAAAAQNRRTQGGDTGAPPEEAGSEISMEFLNALPAEIRAEVLQQEAFESLYRNRRQSGGANERGGSQPGNPPDPGSFLTSMDSGLRQFVLMNGDLYNPQEEMEPSMGRMDLASVLGGRRPSGPRPQPKKAATKHRQRDALQLLDKNGLAILIRLLFYPNLIKKSILFKILTNLIENSRTRNDLLLLLLNILQEGTGDLPAVDRSLSQLTLKGGKQSMATPLSTPTGKLTTKRKHVQETPASPILMQIPPETIPNLLAQRCFETLTTLVSSNSNASSFFLTEHDLSSSVRPRPSKKSKGKEKQTTPVKFPIVLLMGLLDRPTVFKTQMMMDTFTTLLATVTKPLSTLKKEQKDEKPETSEGDGKQQEQQPQIPAADVDATPRPKQKENEEKKNENENEEDDGLKVAPQIPTHVLKYVVNILTVGECSSKTFQQTLSLIQNLSFIPDAKDIIAAELRVKAQEFGQQLNGELVELGDALRKAEKSDDVDASVMEKFLPASSLQARLLRVLKTVDYMFGQSTENISESTEQSSEDRPSSLRQVLGSLMREGRNQEPEAPAEPPAPSKEEAQTNELKVNAIYDSFNFGSVWKKLSENLKLIEENEQMTHIATVLLPLIESLMVVCKYVNPQTAALRTKRMTGSPISPSMHESIEDVFIDFTEEHRKIINVMVRNNPALMSGSFSLLVQNPRILEFDNKRSFFMQRLKAKKRGETYPTLHVNVRRSQVFSDSFQYLQRKTGDEIKYGKLSVKFYGEEGVDAGGVAREWFQVLTQQMFNPDYALFQPCDADRLTYQPNRASYVNEHHLSFFKFVGRIIGKAIYDGRLLDAYFTRSFYKHMLGRQVDFKDLESVDLSYYNSLVWMLENSIEGVLEPTFSVDNEEFGVVNVIDLIPNGRNIMVTDANKKEYVKLNTEFRLTKAIEKQIQCFLEGFHEIIPKDLAKIFSESELELLISGLPDIDVDEWKNQTDYHGFTPSDPIVNWFWRVLRSFDSTQKASFLQFVTGSSRVPLEGFGSLQGSQGTQRFNIHKAYGEEDKLPTAHTCFNQLDLGPYSSYEALRKQILTAIHEGNTGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y536</accession>
    <name>I4Y536_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960862.1">
        <property type="nucleotide sequence ID" value="XM_006960800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y536"/>
    <dbReference type="STRING" id="671144.I4Y536"/>
    <dbReference type="GeneID" id="18474655"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61643"/>
    <dbReference type="eggNOG" id="ENOG502QQTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097282_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y536"/>
    <dbReference type="OMA" id="NTTTHKH"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="67"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="250" mass="27954" checksum="ADAD5A7060ACC3B8" modified="2012-09-05" version="1">MELVVEIPANARKIKDPDDGLTHSETPASPSAKQANSYLANFLTSSLLSSVSFSQPPPDTTTHKAPLNLQTTSVNFRNFVQKTGPIFAILDNIEGIILWRSTNRTILTILVWTLLCLYPRLVLLTPHIALLVLLLRNHAIRYGSNDREAEETPPEPKMPEPTSPDYYMNLQSIQNLMGTTTEVIDGTMPIYKKLNWSDEEASRDILKYVVIALTMTTAVLPWIPVRLLIATGGYIVLAINHPIVKEFIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5B4</accession>
    <name>I4Y5B4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960818.1">
        <property type="nucleotide sequence ID" value="XM_006960756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5B4"/>
    <dbReference type="GeneID" id="18471843"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34255"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126159_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y5B4"/>
    <dbReference type="OMA" id="STNSAMC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="202" mass="23131" checksum="82010EF783F332A1" modified="2012-09-05" version="1" fragment="single">REGTIVQLNWIPGHTGIYGNELADRTANKGRTKCNHYTNIDFTLSTSYSAMRRRMREHYTAPLKIEASKLSVIKSNTSKTSAGKLTAAKTAKILNELPRATRCLATQLRTGHFPTTKSYRYRFKLIDSPKCRTCGIDDSISHRIFICRRHIMARITLRRKITKINIRFELGPMLRNAQALQVLYEFFKPQLTTYPRYSGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5E1</accession>
    <name>I4Y5E1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_22904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960755.1">
        <property type="nucleotide sequence ID" value="XM_006960693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5E1"/>
    <dbReference type="FunCoup" id="I4Y5E1">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5E1"/>
    <dbReference type="GeneID" id="18470936"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22904"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="InParanoid" id="I4Y5E1"/>
    <dbReference type="OMA" id="EMAHSIM"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="219"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="430" mass="48110" checksum="BEDF2C638FC2B02A" modified="2012-09-05" version="1">MRNISFLDNLTPVQAQSIPLACSDRDLLAVAPTGSGKTLAYLLPLLHSLGEPKKEGFRAVIISPTRELAQQIRNELARVGIGRRWRISVLSKANQATMKSDPSTRSKHDILISTPLRLKHAIETEEVDLSNVRHLILDEADRLLEMGFIDQVDTIVGACSHSSIRKSLFTATLPASVEEVSQNILRMPVRMIIGRKDAAAKGVQQKLMYVGREDGKLLAVRQLVQAGELKPPVLIFVQSVERANELFNELVYDGVRVDVIHGERTAAQRDEVIKQFRRGDVWVLIATDVLARGIDVQAINLVLNYDFPQSPASYVHRVGRTGRAGRIGQAITFFTNDDAPYLKSVVNVMKSSGCDVPEWMLKLKKPNSNMRKALKKRPIERETVHEAAGTNVGRDDVKKHKQIVNASKRRKLAKEDVSKEEKDRKEEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5E2</accession>
    <name>I4Y5E2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_52959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960756.1">
        <property type="nucleotide sequence ID" value="XM_006960694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5E2"/>
    <dbReference type="FunCoup" id="I4Y5E2">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5E2"/>
    <dbReference type="GeneID" id="18472601"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52959"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393399_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5E2"/>
    <dbReference type="OMA" id="NIQKESX"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="280"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="473"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="549"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="625"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="701" mass="78908" checksum="317F3FC7D5E8CCE1" modified="2012-09-05" version="1">MQVFVKTLTGKTITLDVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESQDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESQDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGLFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESQDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQVFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQVFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQVFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQVFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H5</accession>
    <name>I4Y5H5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_34184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960714.1">
        <property type="nucleotide sequence ID" value="XM_006960652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H5"/>
    <dbReference type="STRING" id="671144.I4Y5H5"/>
    <dbReference type="GeneID" id="18471834"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34184"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003327_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5H5"/>
    <dbReference type="OMA" id="LWSHAFY"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="3">
        <location>
            <begin position="816"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114326" checksum="27DEA8250DD07EC3" modified="2012-09-05" version="1">MDTENKLIDERRLATTSSKVSLFGQKSNDDLNWIRLVNKHKALADAYHNFLATSLAPHTPTSLHALPQKYNIPTRLWQNAFHGLLEKMRSSLNPNNPNNTLDHLSDFVYHAYAFYTNLLEEPVLSPFKASWIEALGDLARYRMAVSSIESANSSNSPTSLPTSFTTPAPASPNEARIDDSQNDRPPAAMEVASVGLPALRAGGFDIEDRHLWRQVARDWYGQGLRDMPGTGRLQHHLGILCRNSQDSDESLRALYHLCKALTTSHPYTTARETLLSLFDPELQNARKLENRATELFTYAHGILFTKIELDTFPQALDKLLKHLKAERGSLPDVVWIMMGVVNITSLLQYGQDDSILKRTANTVDDAFKRQKQLHTSSSNHSLNSASAFNSPVPPVPALPQAIMMHSNPKTGSSQNLLSSSPRSSHSFENLNRPGSSASTRSEGGDDDVVLSLNKEPAGEEYNTSKIVFEYAQELTFSIFNLLLNNPTSELPGSPLNPYITIVMTHLITILKQSTVLSLLEKKVPWIELSVFLSKLLPNKSTLDKGTKSNSNTPQGPQLSRLVSGAPLPEDWCLRGMEWVGRRVYERGFWKARTGTSTGASYSGAPPPVPGSQIQSEMDVLSNQQGLFNKTPNGSTPQDGLIESDDEDDLEKDLSGLGLSERDENAPTKSNDLDSPLKLAQRRLARLAFSSAILTRLVQGFDLRYLDNENIQFVVRGELEEKIQTWRAEEARKQEDELRRLEGLYQNNTDSDIDSDDLSDVSSLSSAIDSDDDDDEIKQLKIRRKELKNLMREQKKDEIARQQGHTTVVDTLQPGYTTLVFDTNVMLYSIEYVQTFIDSESWICVVPLAVITELDGLSKSDNALGNAALIATSYLDVAVERSKSLKIQTSKNNFLNDLTMRYEDYAVGGMEGFEERKTLDDVILDVAKWQNNNWVERNSSVNAFSLNSPPQSPTLSSSTFSPTLSQASPVRSTAVPFKQQQAKKNITSSKVALITYDRNLRLKGHAVGVTTVNEVEFSKLHKKFFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J7</accession>
    <name>I4Y5J7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960736.1">
        <property type="nucleotide sequence ID" value="XM_006960674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J7"/>
    <dbReference type="STRING" id="671144.I4Y5J7"/>
    <dbReference type="GeneID" id="18473078"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58861"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742280_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5J7"/>
    <dbReference type="OMA" id="RYVHIPM"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="346" mass="39210" checksum="ED97B92AC249B6CE" modified="2012-09-05" version="1">MSKRLKPQLKKLETKNTNYKDHLIKSAPTISSVIEFDPTILISNSIIIGPEPSSASDVDKLRELGVKQILNTALECDDSLSLNNEFKYLKLNMIDNPSAINVQDFLNKGSDFIDDAKLHSRPIYVHCKAGKSRSVAIVIAHLIRANRWDINRAYDYVKQRRETASPNIGFIAELMLFQKDLEIFDYSDEHSNDSTNTPSGSPYANEPDNKLKASFDRLAGCRTPSSRPLSAGPGVLMTKKNKQQKQHGVEQRIDDEMQTRLHLQETLGNHSEVEKKDRSGRYIHPRRAPVDNRLQPLRRVSKAGLESATLDFLKEYDYESKTPTKETIEENPTTNDESTQIVNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J8</accession>
    <name>I4Y5J8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960737.1">
        <property type="nucleotide sequence ID" value="XM_006960675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J8"/>
    <dbReference type="GeneID" id="18474618"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61579"/>
    <dbReference type="HOGENOM" id="CLU_1939728_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5J8"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="130" mass="15113" checksum="DD8AC0435B45CA2E" modified="2012-09-05" version="1">MESNIPFKWRESKRIPHLKPSSRNSPKFVDHTSVGSCVAIPEDFVVNHRTPIVENTTKVIHKPVHLPKKPFFPDRKSSLQKANDENDKIDNKSITKHNRLPSSYMPLEIKEEIKMDKDWATNLLNDAFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M3</accession>
    <name>I4Y5M3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_70715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960660.1">
        <property type="nucleotide sequence ID" value="XM_006960598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5M3"/>
    <dbReference type="FunCoup" id="I4Y5M3">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5M3"/>
    <dbReference type="ESTHER" id="walmc-i4y5m3">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="GeneID" id="18475780"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70715"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_1"/>
    <dbReference type="InParanoid" id="I4Y5M3"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="33862" checksum="FE2F5D159D2D85ED" modified="2012-09-05" version="1">MILNALRRTYISTPTFTPRIHYSQSRWLSTVKLAHEKVDGSVTDEPIVVCHGLMGSKQNWRTLAKNIAQKTQSPVYTLDLRNHGTSPHAEPHDYTHMAADVSQFIEENNLKNVTLIGHSMGGKVVMALALSKPHLLRRLIVADMSPQIAEISKEFRAYTERMAEIENADVKSKKEADQMLQTVEPNMAIRQFLLTNAEMNKDTGFYKFRIPVEILRDAIPAIGDFPYKAEDEVTFDKPTTFVKGSNSAYLNHKNIPLAEKFFPNMKLVTFQAGHFVHTEKPFEFVQLVTDDIESDRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5V5</accession>
    <name>I4Y5V5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_70688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960623.1">
        <property type="nucleotide sequence ID" value="XM_006960561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5V5"/>
    <dbReference type="FunCoup" id="I4Y5V5">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5V5"/>
    <dbReference type="GeneID" id="18475775"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70688"/>
    <dbReference type="eggNOG" id="KOG2074">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017639_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y5V5"/>
    <dbReference type="OMA" id="FWKRYFE"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="531" mass="60381" checksum="AC93A8F99BB4A70B" modified="2012-09-05" version="1">MEIKVSYKKQSGNLNLLDDRLEFSSQNSFNLNYSRLLTLFASKQGSTPVRLKLDLSDPQQSITFTFIHPTHALSQREHVKDRLSNAIASNRASSSRQVESQLTSTTPTTRSSTPGLGLSKDDLEIRKKVLIKDPQLAKLHKDLVIAGIIDENEFWQGRQQLLLLEHLSQSQKPGKSSTLVDPRPTSSQPGEFTITITPQLVHDIFQEYPVVQKAYVENVPNPLNDNDFWIRYFHSHLFARHRASSRQDANEARNDPIFDQYLEEADDGVEPKHKQRGVYDKLIDLGSTQEDHKETGNALDITMQAGKVKAALPLMRRFNEHSMRLLSTTVGDEEGAHDNDYNNQITIDDLQEHQLPQPIRLNMQNSEQYYTSNIVTTGDYQQSSQLDSKTIWDDIKNNLDEWDVVITLEDIKDTKDAQTEVEKILSANAEIAYNDINSNEISNSDIMKAAINCHTAATEFLRLYWTTVLSYPIDIPKVNKMIDYINKTPQKVDAIVRSASAMNQGDLIRQALQPVMNGVTKVKEYERNRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5W5</accession>
    <name>I4Y5W5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960633.1">
        <property type="nucleotide sequence ID" value="XM_006960571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5W5"/>
    <dbReference type="STRING" id="671144.I4Y5W5"/>
    <dbReference type="GeneID" id="18474586"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61530"/>
    <dbReference type="eggNOG" id="ENOG502SBK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036734_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5W5"/>
    <dbReference type="OMA" id="NRWIRMW"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="394" mass="44113" checksum="BFA723B7B0DDC4AF" modified="2012-09-05" version="1">MSGKASFAKILQRSKYATYDPSISQVYSAAAANRARGDFGFKRPIQGPPNVRVKSQDNELGVVEYINADGDVKVLQRIEEMRIPFDNKESTSANEYSSYVDKSSIEDTILGQFGRPEVELMDKQEFDNYLQRVKSLRGEFKEFLNNQALDVAKKQAELKGENPDNVKTPPVDLYNSAQNDPYVHQQFLKQYHAKVLTEKDSKHLTPNPHFNGGLRYSTPSPIESSKLSPSIPGRILPNSSNNSRFRREKKPIALAGLVASTDMSNLTGLSATDFASEYGQQSRDLNAGQAKFRVMNRANVSRVPRVVNTSSDRPLDGAVIDIELLESSAIEKLQNKSEAIGSPEYVSTFEKDIPSGRNRPVSMFKTINSPLFNRKKENQGTELKISELLKQHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y600</accession>
    <name>I4Y600_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_22484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960542.1">
        <property type="nucleotide sequence ID" value="XM_006960480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y600"/>
    <dbReference type="FunCoup" id="I4Y600">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y600"/>
    <dbReference type="GeneID" id="18470924"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22484"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055314_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y600"/>
    <dbReference type="OMA" id="VCEAFIS"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25930" checksum="951A6B22B970DCB6" modified="2012-09-05" version="1" fragment="single">SGRPFRTPSGHTPKWTDEVKWTSANVFDQNTYADVIKQSDAVVHTIGILLESDYKNGPLDALKGLIAGRENPNPLTGGLYERLNRDAAIRVADVYKNTRTTQEDNPFVYISAADIFRPLIPSRYISTKREAEEYLKRLDGIRDISLRPGLMYHPHTRPISTIPATMIDILNKLPKPFINGLDADSNLQSVQNLLHTSALHIDTVGAAALEAILDKSQSGDVNVDDIKRLAWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y611</accession>
    <name>I4Y611_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_22509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960553.1">
        <property type="nucleotide sequence ID" value="XM_006960491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y611"/>
    <dbReference type="STRING" id="671144.I4Y611"/>
    <dbReference type="GeneID" id="18470925"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_22509"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y611"/>
    <dbReference type="OMA" id="WAERLFT"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="22962" checksum="E2EE1B3E8365977B" modified="2012-09-05" version="1">MISNLLGIGIVVGSSLIKIPQLYTIYTKSSRGLSLSAFALETIAYFVNYVYGYVHAYPFTTYGENLTLTFQNIIIVGFILKSKFKTILFAIFTLSFIFTPKEFVDITFTLSIPLSLASKLPQIFSNYRNKSTGSLSPITTFAQFAGCCVRVLTSIKNANGDIPMTVSFAGAAALNGVLILQIVTYSRKQHSFSLPSHHRAVSKEKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6C7</accession>
    <name>I4Y6C7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_55543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960444.1">
        <property type="nucleotide sequence ID" value="XM_006960382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6C7"/>
    <dbReference type="STRING" id="671144.I4Y6C7"/>
    <dbReference type="GeneID" id="18472734"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55543"/>
    <dbReference type="eggNOG" id="ENOG502RZMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039848_7_0_1"/>
    <dbReference type="InParanoid" id="I4Y6C7"/>
    <dbReference type="OMA" id="VMMSWDG"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="346" mass="39694" checksum="7C33083998F31A98" modified="2012-09-05" version="1">MSEQLRAIIGDNSIRVESQSTTVSPFGILNDDRIEKDAVYDFSSISRDNTWIVLRAIWAATNREYLAIEKPSDEKYAYIVQSGLGFDSPSDSAVVILSRESFWQGAGASVENHWLKATTAVDFSPVSAFPQIQSFTKNELVATVHPLRPPKPAPGTVFYERYINVVGQSLSFVHIDGTNTEHFEFYKKWQNSDRVNVGWREKGPDEKHHQYIKDRLEDKHMMGFIFCWNGKPAGYGELAWVKEDPINVYCGGMEDYDQGIHLLVGEEEFRGKDRFVATVTSMMHCCFLRDARTQNVVIEPRVDLGLGPRLKALLPVELNREFEFPHKRAFYYKQRRQRFFQAASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6F4</accession>
    <name>I4Y6F4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_55497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960344.1">
        <property type="nucleotide sequence ID" value="XM_006960282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6F4"/>
    <dbReference type="STRING" id="671144.I4Y6F4"/>
    <dbReference type="GeneID" id="18472732"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55497"/>
    <dbReference type="eggNOG" id="ENOG502S0JD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="I4Y6F4"/>
    <dbReference type="OMA" id="EWDRRAV"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="31473" checksum="A12EC14B9E0229AF" modified="2012-09-05" version="1">MVSLLTGVTGNQGSQVLEHMKGQPVRAFVRNTKNNKTKKLQERGIELASGDLKDEESIYTALENVDGAYLVTLMLEKGAQDEVEQGKAFLAAAKRRNLKHLVYSSVEGAERQTGIPHFDSKFEVEELIRESGIPHTIVRPVAFFDNFPKQRGLASFFTLGIFRAGTGYSKKIQLVSCYDIGRVVAAALKNPSKYAGQVIPLAAEELYVSEIQDKYEKALGTRPWKAWLPRFFLYLLPYDIRCMFLWFGQRGRGYRANIPALRREYPGLLTFDEWVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I3</accession>
    <name>I4Y6I3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_48832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960373.1">
        <property type="nucleotide sequence ID" value="XM_006960311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I3"/>
    <dbReference type="FunCoup" id="I4Y6I3">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6I3"/>
    <dbReference type="GeneID" id="18472470"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48832"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="InParanoid" id="I4Y6I3"/>
    <dbReference type="OMA" id="SSFWNVA"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="57"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="206" mass="23569" checksum="8ACF8622C5CAF2D8" modified="2012-09-05" version="1">MIKSIWNNRRQISRIALRSSLLTLQIWCGAEIFRMYFADIQLSYGISMIPTIESSGAWLLHEPISVKKGLQNDVFDNTTEEGKTVLQQLRKEYGTGIRRGDLVVAITPDQPDKSICKRVVGFPGDRILRDPLYLQMTKRFQDITDDEESRYIQVPKNHVWLTGDNLTNSRDSRSYGPVALPLLKGKVFAKYSDNFLPVKNGVFVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6M4</accession>
    <name>I4Y6M4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960279.1">
        <property type="nucleotide sequence ID" value="XM_006960217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6M4"/>
    <dbReference type="GeneID" id="18471766"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33885"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059620_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6M4"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697440" evidence="2">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="27776" checksum="8191B1263D0178DA" modified="2012-09-05" version="1">MPVERTILTLVPFWLGLLVTVLGDSPLDRLYGPDIAEHPEAIVTIVIVVIVIVILGFNQARVFRKYGKFWTYIKWYFLLGLFVIMPACLLPELSFRLHHYILALLLLPLTALPTRVSLICQWFLIGLLLNGVARWGMDSILQTADSLRRDAALGSLLPSFSGLDNSTIFWNDIPANADWDGFKLLINDVLKLSANSSTLSYRLEDTDTDIPYYARLAYSNGNEAGDFTKAATIWLNNSTFIPPRPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y4</accession>
    <name>I4Y6Y4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">WALSEDRAFT_48643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960234.1">
        <property type="nucleotide sequence ID" value="XM_006960172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y4"/>
    <dbReference type="FunCoup" id="I4Y6Y4">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6Y4"/>
    <dbReference type="GeneID" id="18472461"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48643"/>
    <dbReference type="eggNOG" id="KOG1775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_6_1_1"/>
    <dbReference type="InParanoid" id="I4Y6Y4"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="87" mass="9701" checksum="CFAE560B6DD22A0C" modified="2012-09-05" version="1">MASQILPLELIDKCIGSRIWVIMKNEREFVGTLQGFDDFVNMVLDDVTEYDISPDGTQKKSKLRQTLLNGNNVCMLLPGGEGPESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y717</accession>
    <name>I4Y717_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_33882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960267.1">
        <property type="nucleotide sequence ID" value="XM_006960205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y717"/>
    <dbReference type="FunCoup" id="I4Y717">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y717"/>
    <dbReference type="GeneID" id="18471765"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33882"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y717"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="258"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="382"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="504"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="612" mass="68699" checksum="8123CF1E10340BD1" modified="2012-09-05" version="1">MIAIKLQRKHPEFSQEEVMRLVDTFQQLDVEGKGVAQQDIIKSLQNEATYDQVRETLKDVSVDASGRVEVEDYVDLISKLKAGQNANAGVVQKGKVTVKGTSSNVSHTINEDERSEFTRHINQVLDGDADVGNKLPLPTDNFQLFDETRDGLILSKLINDAVPDTIDERVLNKPKGRTLNAFQATENNNIVIQSAKAIGCQVVNIGSQDLVEGREILILGLIWQIIRRGLLSRIDIKNHPELYRLLEQDEALEDFLRLPPDQILLRWFNYHLKNAGWHRRVSNFTKDVSDGENYTILLNQLKPAECSRQPLQQTDLYQRAEMILQNADKIGCRKYLTPNAMVGGNGKLNLAFVAHLFNTHPGLEPLNEEEVPEIEEFDAEGEREARVFILWLNSLDVNPAVYNLFEDVSDGLVLLQAFDKIAPGSVVWRRVAKPKPEQELSRFKRVENTNYVCELCVKNGMHLVGIQGADIVDGTRTLVLGTVWQIMRLSIGVTLSSLSKNGKQITDVDMVRWANDRVAQAGKRSSMRSFKDSSLRSGHFFLDLLDALKPGYVDYSLVNDGRTDDDAFLNNKLAISVARKIGCLVFVVPEDLVEVRQKLVLTFIGAIMAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y737</accession>
    <name>I4Y737_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960113.1">
        <property type="nucleotide sequence ID" value="XM_006960051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y737"/>
    <dbReference type="GeneID" id="18475711"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70309"/>
    <dbReference type="HOGENOM" id="CLU_2943618_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y737"/>
    <dbReference type="OMA" id="APENMPI"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="61" mass="6577" checksum="64D5411EB89E2FC5" modified="2012-09-05" version="1">MDSAKPGYLTTPEGPTNEGFLRKCIKSSMSPDNLPIVWGSTFFIGSIAFIRVAGELLVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y771</accession>
    <name>I4Y771_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960147.1">
        <property type="nucleotide sequence ID" value="XM_006960085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y771"/>
    <dbReference type="STRING" id="671144.I4Y771"/>
    <dbReference type="GeneID" id="18475076"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66003"/>
    <dbReference type="eggNOG" id="ENOG502SAI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167733_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y771"/>
    <dbReference type="OMA" id="TSWQESG"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12303" checksum="F6C3F010C3C35F67" modified="2012-09-05" version="1">MQVTGSIENVASFLPHLATMSTDPSKTNAQYNSTVGSGKEFIGNTIGSQDLSKSGKEQHAQGEAERKEAEAKQYGEGLVDSATGKAKNIGGAITGDKDQQARGAAREQKGETKRDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7D2</accession>
    <name>I4Y7D2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_40616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960016.1">
        <property type="nucleotide sequence ID" value="XM_006959954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7D2"/>
    <dbReference type="FunCoup" id="I4Y7D2">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7D2"/>
    <dbReference type="GeneID" id="18472182"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40616"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y7D2"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="174" mass="19928" checksum="B173422FA42874CF" modified="2012-09-05" version="1">MELQVDQLKSQQVALGSWAFLFSEIINYNLKRVDGIAELESKLNWLGYRVGQRELELYKFRQEGTAKNPRQHTSLIEVLQFIHTHIWRSLFGKTADSLEKSKENANEYMISDNTPILSRSISIPKDLKNLSTESFTSGIVESVLDGLNFKSKVTAHSVPTEQYPQRTTILIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7J8</accession>
    <name>I4Y7J8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_5447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959993.1">
        <property type="nucleotide sequence ID" value="XM_006959931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7J8"/>
    <dbReference type="STRING" id="671144.I4Y7J8"/>
    <dbReference type="GeneID" id="18472673"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_5447"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_9_1"/>
    <dbReference type="InParanoid" id="I4Y7J8"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="99" mass="11309" checksum="5E8A9F35FA6CE9A9" modified="2012-09-05" version="1" fragment="single">ENSYEARLNLAGYKKEELDISIHDHKITVKATHPAEEDKDNGFSYLINESRSSSIASRTWKLPEHVTEDNIHASYTDGLLTLRYSRHAPESEPKKISIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7L7</accession>
    <name>I4Y7L7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960097.1">
        <property type="nucleotide sequence ID" value="XM_006960035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7L7"/>
    <dbReference type="GeneID" id="18471125"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30031"/>
    <dbReference type="HOGENOM" id="CLU_1751115_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7L7"/>
    <dbReference type="OMA" id="QEGVNFG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="149" mass="16997" checksum="EFAAB1AB032811B7" modified="2012-09-05" version="1">MKYKEAQSLEYKAQVPSFIRRMKGENVDGEEEEEEELDEFGRSRQKRSEVVENQEEEDEKDPIKALLKDGAQIDNLEDLVDKPKSSTPPPGSPTQQDTPKKVKQDGVNFGNNKTKKRKTLLVDSSSEPSSSKQQKKKKQKQNKGLLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7P0</accession>
    <name>I4Y7P0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_70143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959913.1">
        <property type="nucleotide sequence ID" value="XM_006959851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7P0"/>
    <dbReference type="GeneID" id="18475691"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70143"/>
    <dbReference type="HOGENOM" id="CLU_1866695_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7P0"/>
    <dbReference type="OMA" id="HDEHEKH"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="137" mass="15700" checksum="7B710D82931EA6A6" modified="2012-09-05" version="1">MSTFNEIKDWPLDVIDEQIKRLENSVYHLERTNKELLAFLPKKSQNKLIEGSFEAQSIGSRDQEIQAMEDEEQLRRLSDDNGDDTELVNGVIKENEYTIASQNERISLLKYAKALRLNTHEEAPKETPPAPSTGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T4</accession>
    <name>I4Y7T4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959955.1">
        <property type="nucleotide sequence ID" value="XM_006959893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T4"/>
    <dbReference type="STRING" id="671144.I4Y7T4"/>
    <dbReference type="GeneID" id="18471724"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33649"/>
    <dbReference type="eggNOG" id="ENOG502S879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y7T4"/>
    <dbReference type="OMA" id="IKGWQKA"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="161" mass="17656" checksum="422C24B77F544A6A" modified="2012-09-05" version="1">MTDEHPINSKNWWHAYGEPNTAVKEMSVDELAGLYSSGTPGVDFVVIDVRRADLSEIIPGAINLPSQSLPATLPSLLHSLNNVKKFIFHCNSCQGRGPRSAGWFADALNKHLDHIGAHNDTKDRVYFLKGGINAWKDKFGTGELTGRGKAWDGKSLSTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V3</accession>
    <name>I4Y7V3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959974.1">
        <property type="nucleotide sequence ID" value="XM_006959912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V3"/>
    <dbReference type="FunCoup" id="I4Y7V3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V3"/>
    <dbReference type="GeneID" id="18474392"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61206"/>
    <dbReference type="eggNOG" id="ENOG502S2NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029055_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7V3"/>
    <dbReference type="OMA" id="ICRDIWA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="61"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="12">
        <location>
            <begin position="255"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="543" mass="63352" checksum="7DB5E51CE637118E" modified="2012-09-05" version="1">MCVEGHIYEGFRNETQEDAMPKHIGKQRYIKKEATERRKVLKSHRWYTGDKLRYLHLQAQQVVLRYQVRSLMSAWNLPPEFEAIVKDLWALRLSLLKDLVAAPLELGLKHQRGEHTDEDDDLKDDTSEKDEKDDDDDKERVSDIGDPDEMLEKPWSDDDDDIQMPQTMEEALEAAKKIKTARRTQNSVDEFNMIWLLATLNLAFWTLRLPVFYLDFKNALETRVLPYMDALSCLPETMKERLNPGSRSSFQAEAVPSLRKIHRASIYLARQYDEKYKITFNDYNSAPILWRCVHDMGLPPRIYTLCQEMLKRLDTHFTLLPKRKVGKRSRHRKGESSAPEIITMSVVVTMCTLVYNLENEITDQPRVGSLLDKNKWLLSLEEHFKKSDTILNDQIEIIDATDEQIEDFLDFMEKTIPPANEETVKTWPTFGEDLVSRGDPMRVSAIDKDKDWFHKLYEDRIPLHDYPSQSDSVIIRSYHTSDVLGDYPKLLDKLLKASAKAIGIAHIEEIARLVELFQKRLVWRRNNTSLNTRNSLNSLKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y808</accession>
    <name>I4Y808_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959821.1">
        <property type="nucleotide sequence ID" value="XM_006959759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y808"/>
    <dbReference type="FunCoup" id="I4Y808">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y808"/>
    <dbReference type="GeneID" id="18474344"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61123"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_3_3_1"/>
    <dbReference type="InParanoid" id="I4Y808"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="274" mass="30419" checksum="4F91DC4BA38AB9F7" modified="2012-09-05" version="1">MQGSKILGIARASTTPIAPPFVHLPLRHLFHPKSGFVEKQAVPLPSDAFNAPLRRDILHSCVRSFLFSNRDGTIAHVKNRHEVAGSHRKQRPQKGTGHSRMGTKQSPLLVGGGQAHGPRNTRNWKRKVNKKVWALGMKVALSDKIRSGELVAIPASHLDIPRTNKLSRQLSNLGLLDRTLFVSSDITLHLASRNIPTIDTLTPEEVDVYDVLRAKKVVVDVQALNSLYHKIQIKAGEIEGSVEEPEEFGFETPALTEQEEQALLEKADFVLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y866</accession>
    <name>I4Y866_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_40450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959879.1">
        <property type="nucleotide sequence ID" value="XM_006959817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y866"/>
    <dbReference type="STRING" id="671144.I4Y866"/>
    <dbReference type="GeneID" id="18472174"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40450"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_4_1"/>
    <dbReference type="InParanoid" id="I4Y866"/>
    <dbReference type="OMA" id="KMDHREI"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="161"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="512" mass="57615" checksum="EB57A785A20C0B50" modified="2012-09-05" version="1">MDTMRQRMQQIEAEQIESRKRQATTDELNAAKASHIEEISTMKHEHKARETELEDELHNLHKVQKALEEELNMEKAHSKKLKTELAKFTNNSMALETDVRKIKEALSNAEHRLEMAKEKGASREDEMASMITKQAEMENELRAGESLRKKLHNTIQELKGNVRVFARVRPKLDRDHTAEVANFVYPDGMNRDGGKQITLQSSTLNAEGKSRDQSYNFSFDRVFGPQSLQEEVFGEIEQLTQSVLDGYNVCIFAYGQTGSGKSWTMEGGSHKGIDAGMIPRAIYHIFDTTRKLEDQGWSFKLHGQFLEIYNENIIDLLGSGEQEKKHNITHEKSGSTTVSDVVVVPLSEPSHVHNLLRKANKKRTTASTRVHEQSSRSSSVFSLKLEGSNEVTGEHCKSVLNLVDLAGSERLDSTGTLNDPTRLKETQAINKSLSSLSDVISALGSGSHVPYRNSKLTYLLQNSLNNNSKTLMFLNLSPMQDHLQESLCSLRFALKVHSTHIGQAKRSMVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y888</accession>
    <name>I4Y888_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959668.1">
        <property type="nucleotide sequence ID" value="XM_006959606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y888"/>
    <dbReference type="GeneID" id="18475667"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69955"/>
    <dbReference type="HOGENOM" id="CLU_1195668_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y888"/>
    <dbReference type="OMA" id="NHERQRG"/>
    <dbReference type="OrthoDB" id="10521024at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="232" mass="25908" checksum="BBE1F42FD24A68BF" modified="2012-09-05" version="1">MSIKNFKDKINPLLSDEHKEKLNRAYSDNLLATQSNRRSNNYIIARVEDWYRDRKNHNPAASASLQLKSELISDLYDKDPNFGIGTFSVPFQLQEAPSFHGVYTNTYGNIPANFPGSFIQTGQQAVGNPTPLHVYLNQQASSSSKLFASAVWNLANSGRLVVLPESFAYNRERERGAVAEVVAPSNTDAFADFLEQYNAMLSTNNHVNTPNNTANSTDSSFDKNIHSIPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y894</accession>
    <name>I4Y894_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_33442</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959674.1">
        <property type="nucleotide sequence ID" value="XM_006959612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y894"/>
    <dbReference type="FunCoup" id="I4Y894">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y894"/>
    <dbReference type="MEROPS" id="C19.A59"/>
    <dbReference type="GeneID" id="18471681"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33442"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003532_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y894"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MATH/TRAF_dom"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C19"/>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
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        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
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    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="12">
        <location>
            <begin position="51"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="209"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00009085"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EIM20186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1110" mass="128612" checksum="D0D87502539E5C11" modified="2012-09-05" version="1">MEPQSIDYSSQEDEKTGLVSEMEIDDTISVNDVPAFVERNLSDFGHEVIDFKTYTWDLSHWTNLDRRIQSPVFDVGGHPWRILLFPFGNTNGNGNEMVSIYLEYADPRGAPVGWHVCAQFALVMSNPTDPSVFVTNQAHHRFTIEESDWGFTRFSELRRLCIPSDKFSRPVIENESSTITAFVRVLDDPTGVLWHNFVNYDSKKETGFVGLKNQGATCYMNSLLQSLYCTNYFRKAVYQIPTDEDHPSESVASALQRVFYNLQNSLQPAGTTELTRSFGWKSLDSFMQHDVQEFNRVLQDKLEERMKGTVADGAITDLFVGKMKSYVKCVNVDFESSRIEDFYDIQLNVKGMKNLYESFKDYIQVETLEGENKYHAEGQGLQDAKKGCIFESFPPVLHLQLKRFEYDLQRDAMVKINDRHEFPLEIDLKEFLDDGPAKEENWVYRLHGVLVHSGDLHGGHYFALIKPERDGQWLKFDDDRVTKVLDREVLEDNYGGEMHSNVVTAQGPKPQLRAMKRFTNAYMLVYIREKKMDEILQPFTNDDIPPQLRQRLDEEREASERKRRERDEQHLYLTTRIISDNSFSTYQGFDLATFEDRNVPATELPTIRALKSMPYNEFKEQIRRQFGLGDLKFRLWMLVNRQNKTIRPDTPILETDPTKTLDAIRVELSPRQNDLKLYLDVEAENDSQYGKPEDSIMIFLKYFDVSRQTLTGVCKVYVPRSAKVGDLQDIIQKEMKWPPGLPLRLYEEIKPGYIEPMKPKMTLAQSELQDGDIVCFQVELSESEVRDYEAQGMNADPISHYDYLQNRVQVTFRPKYKNQINENVTEFKILLSKKTNYDRMAELVGAKVKQDPLKLRFTTTQNTNGTPKSIVKRSMNQPVQDLITPGYLTENSHVIFYELLNISIVELETKKSFTVTWTGLNNREEGSYPFLQPKTSTISDIVEQLSKNVQLSPEGSQRIKIFEIWNGRQQKEYTGVELIGNLADNAELFAEEVPKEEVDASETDKIINVFHYSREPQRWHGIPFKFVTKPGEKFIDTKQRLQQRLNVAEKEFAKYKFSLITSMYYKQPSLIDDGDVIHDHNFAQQDALGLDHIDKSGKFNKSAERGILIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C0</accession>
    <name>I4Y8C0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959700.1">
        <property type="nucleotide sequence ID" value="XM_006959638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C0"/>
    <dbReference type="GeneID" id="18475033"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65567"/>
    <dbReference type="HOGENOM" id="CLU_1469331_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8C0"/>
    <dbReference type="OMA" id="YLIHECT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20956" checksum="CD9A90B204AD78E5" modified="2012-09-05" version="1">MNESTQENTPKRHKISCQVTDCNDEVFQDSIYCLKHRHAGTSTPTAQKRTINTVQADKLAAIKSKFGSKHAPTTKPKKFDKKIWAMKIRMNAKPLREVLDSSDRIHISVSTENTIELTSSRFYYFSKALSIGRLLDIICQKFSIDSSKCEMYKKDTELVKLNLSSIAGETPDLDCSHIWLKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D9</accession>
    <name>I4Y8D9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_52273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959719.1">
        <property type="nucleotide sequence ID" value="XM_006959657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D9"/>
    <dbReference type="STRING" id="671144.I4Y8D9"/>
    <dbReference type="GeneID" id="18472579"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52273"/>
    <dbReference type="eggNOG" id="ENOG502QPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013967_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8D9"/>
    <dbReference type="OMA" id="AYRQVYA"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="409" mass="46375" checksum="D6BB88A66446F828" modified="2012-09-05" version="1">MWGGNGGTKLSFVSGSCVTLGFPYRPAGHFRIPGFDLLAEHIKKHTMDFMIFLGDFIYADIPLSIGTSPENYWRKYRQTMSSDSFRKVYEQLPFYHMYDDHEIANNYAGQDNLNVSPYREAMIAWKAYNSAGNPDALTPNHSYFSFDYGDVAFFTLDTRAHRSANQEDDGPEKTMLGETQKIALLEWLSEVNNTATFKFISSSVPLTQLWKGVDGHLDTWAGFKNERKWLLDILQYVPNVIILSGDRHEAAAVELRDAITEFSTSPLSQFSVPIRTFKQDHTEWIKDVVRKEDLKHLYPYLVSDGKGRLSHPDSLIHTTVEDGDYVTISKPEDRVLAYLPDGFVKWTTFDVDTTSSMPTVNATIWIDGKATWSKVINGKPIRQSSSALSLIDSVGDIFDSIGMKIFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I2</accession>
    <name>I4Y8I2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959762.1">
        <property type="nucleotide sequence ID" value="XM_006959700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I2"/>
    <dbReference type="GeneID" id="18475039"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65625"/>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061193_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y8I2"/>
    <dbReference type="OMA" id="KDLQWYA"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="141" mass="16489" checksum="24132D14BA2B8B9E" modified="2012-09-05" version="1">MEGEPIRGGTRGGAGNFSWNAVKEDKHREYYLGHSVKAAAGRWQKNKDIHWYNRDQDSGDEEEVKRKKKAEIQKIKEAEEDALSLALGYIPKPRPSEEESLAAKAQKNAEKRVRKEQRAKVREERERRREHRYKSSKSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8M2</accession>
    <name>I4Y8M2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bax inhibitor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_33378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959571.1">
        <property type="nucleotide sequence ID" value="XM_006959509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8M2"/>
    <dbReference type="STRING" id="671144.I4Y8M2"/>
    <dbReference type="GeneID" id="18471666"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33378"/>
    <dbReference type="eggNOG" id="KOG1630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046868_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8M2"/>
    <dbReference type="OMA" id="TLMWSER"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35189" checksum="A4A2A4F557B2B652" modified="2012-09-05" version="1">MFKVGIQSISKSVQRTGCLKLQPAAIQQRFISSSSKRLLPRIGGGGFNNNPSARYTFEEAKSGFNTSPDAKSKYVTAALAVGGTILGTHFVLNRETREGGLSPFEAKYLNETFTWLGGGLATVTAFSVGLFRSNVTARLMSMNPWAFAGISLVGSIGSLMGLRSVAPDNKGGKTAFWFLFNAAQAATLSPLLYIAPPALMVRAGLYTAGVIGSLSYVGATSKNDTYLYLGGPLLAGCVVIAISSLIPMFRVGAGVANAASNVSLYGGLAVFGGFTLYDTQRILQKARMIEGGAPIPYDPLNESISLELNFINLFIRILTILMNQQGGNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8M5</accession>
    <name>I4Y8M5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_47676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959574.1">
        <property type="nucleotide sequence ID" value="XM_006959512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8M5"/>
    <dbReference type="FunCoup" id="I4Y8M5">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8M5"/>
    <dbReference type="GeneID" id="18472423"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47676"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_12_2_1"/>
    <dbReference type="InParanoid" id="I4Y8M5"/>
    <dbReference type="OMA" id="NEDMPVW"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="15518" checksum="F56264BA7F3F590A" modified="2012-09-05" version="1">MSVPIGPIEPLSQTPNFTETELGQFKEQDRFLPIANVARIMKRSLPDNVKIAKEAKESVQECVSEFISFITSEAQDRCLLEKRKTINGEDLIHSMSALGFENYSQVLKIYLAKLRQHQSQKNDQDQFDEEDLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U2</accession>
    <name>I4Y8U2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_55149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959640.1">
        <property type="nucleotide sequence ID" value="XM_006959578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8U2"/>
    <dbReference type="FunCoup" id="I4Y8U2">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8U2"/>
    <dbReference type="GeneID" id="18472716"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55149"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043579_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8U2"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="429" mass="47524" checksum="D49346089AAEDEDE" modified="2012-09-05" version="1">MSDDARKSLNLALSYYDKGNLQSALKFAKKSIRIERIQQAIDLIDDIEKKLANGETGTSTASSAQPNKDNLRNRQEKPQPKEEPSKGWTPAQQTLVKRVRSCKPTAYYEILALEKTCSDNDIKKAYRKLALQLHPDKNSAPGADEAFKLVSKAFQVLSDEDKRASYDKFGSDPDARFGSGGGGGDPFAGMRTRSAAGPQFESEVSPEDLFNMFFGGGMGGMGGGPFGGNAFGGGPFGGNAFGGGPFASSFGGPGFSMRFGGPGMNSFPNTRRYPRQQQAQPQSMMQQLLPILILIGFTMISYLPSLLGSLFSVPPPAFSLDKTVFYSLEKTTGSPHNVKYFVNPSQWRDHPYSQNKEVPQTFSKEVEKLLAQRLGRKCKYWLQDRDRRIERYSGFFGIGKDDEKLEKVYKETNENCNRLRELGYSVNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9A7</accession>
    <name>I4Y9A7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_58060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959343.1">
        <property type="nucleotide sequence ID" value="XM_006959281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9A7"/>
    <dbReference type="STRING" id="671144.I4Y9A7"/>
    <dbReference type="GeneID" id="18472981"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58060"/>
    <dbReference type="eggNOG" id="KOG4144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070381_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9A7"/>
    <dbReference type="OMA" id="WCEEGGS"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="315" mass="35637" checksum="3CE66EBDB59F8E4A" modified="2012-09-05" version="1">MFDESYIIDKLEHQELSSAASIDNSSYTATDIDKLEYRYKYAGDLFLGIFHQPRTQGLIGFVTSTLTNEDTFSEQSAKEHDPSGHTVLIHSLTVHNEDAHRETATTKLFTEYMRRLDESSYNRVLIISSKEQVPFFEKYQFEITKEIDNDQVEMSHDITPQKKPSITQADILAALSKPSTKPNLNLLTFTDQSKYEDFLKDSKNSRNARCPRVECKSLVFLSGAADLKSLETIHPLSILPPDNQFSHPSLPEPHLDKAWRLAGPMSFENITFSKTAPQTAANISKFLACGECEIGSLGWVDNAGCWIDVKRVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9B3</accession>
    <name>I4Y9B3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_47338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959349.1">
        <property type="nucleotide sequence ID" value="XM_006959287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9B3"/>
    <dbReference type="GeneID" id="18472416"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47338"/>
    <dbReference type="eggNOG" id="ENOG502SDSR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1836676_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9B3"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="16556" checksum="CEF03DEFCB83E3E8" modified="2012-09-05" version="1">MNNLVEYYKNDCYKLPFNSLYCNDIYNNQENRISVAIELTICDIKTTKSLTIPLECIGEYDKSYCLDAISRSSQLWSSYSGYFRDSLTICQSFKPEIIQTEFLNNQLTILDYLTRLQQQLNTQIDYHEHLDKKLLMIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I8</accession>
    <name>I4Y9I8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959414.1">
        <property type="nucleotide sequence ID" value="XM_006959352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9I8"/>
    <dbReference type="FunCoup" id="I4Y9I8">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9I8"/>
    <dbReference type="GeneID" id="18471645"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33248"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9I8"/>
    <dbReference type="OMA" id="QVMFNDF"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="81"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="268" mass="31199" checksum="94B7718244CE6589" modified="2012-09-05" version="1">MSGTLEDLSADQKQALDTFRETIKAKDYYNEKRHDDRGLLRFLRARKFDLQKSEEMLDAAEKWRKEFGVDAIKESEFDQNELETINKYYPKFYYKTDKDGRPVYIERLGYLNVPELYKATTAERMLKHLVYEYEKCFDSRFPACSEASGKHIETSCTILDMYNVGIKSFYDVKDYVAQASNIGQNYYPETMGKFYIINAPFLFTTVWSVVKGWLDPVTVSKIVILGKSYKDDLLKQIPAENLPKDFGGKSEEDIFSDPGPWNPKTNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K0</accession>
    <name>I4Y9K0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_60898</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959425.1">
        <property type="nucleotide sequence ID" value="XM_006959363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K0"/>
    <dbReference type="FunCoup" id="I4Y9K0">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9K0"/>
    <dbReference type="GeneID" id="18474235"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60898"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y9K0"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="916" mass="100273" checksum="12EA2211CD14A816" modified="2012-09-05" version="1">MTCSSCVQSIESYIGKLQGVNSIQVALLSEKATITYLKDYWDPEKLANEIDEMGFEASVLTDLNSSSIIDISIFGMTCSSCTSSIETALSNLEGVINADISLPLEYARIQFNPDIVGVRDIVELIQETGFDCMIRDDRNDSQLKSLSRIKEVNQWKSALKYSAYFSIPVFIIGMVLPMIPSVEPIIFYNLWRGITIGDLSCLLLTLPVQFGVGKLFYKPAYKSLIHRSATMDVLVVFGTTAAFIYSTGVMISSIFTWSNNSIIPQTFFDTSTMLITFVTLGRYLENLAKGKTSSALSDLLQLAPNSATIYLHYDEDHSNDLQFEEKQISTDLLQKGDYIKLVPGERLPADGYVVKGSSSIDESMITGEPIPIVKEKGDTVTAGTMNNNGTIDVCVTRSGTDTALSQIVKLVEDAQTSKAPIQAFADKIAGYFVPVVISLGLITFITWLILSYLIIPQSSLPHIFNQPGMSNFAVCLKLCISTIVVACPCALGLSTPTAVMVGTGVGAQNGILIKGGQALEQASKIKRVIFDKTGTITKGDVNVAAIEWNEESFSDNVHSLGFTKDDVMRIVALVESKSEHPLGQAITNHFNDYDLTSKNTEIVLKDWVSHTGKGVEAQVSLTFPQYSSNQLIYKIQIGNNSITSNDIKEPNIFEQFKNINSIKGFTIVYVTIESEPIMVIALGDEIKSNVMETVNCLMNNSIESYLMTGDQMSTALSIAQKAIIPKDRVFAGVSPKGKRERVIEMMKDNDGTVAMVGDGINDSPALAAASVGIALASGSSIAIEAADIVLMRQGEIEDVFSSIQLSKAIMKKIKMNFLWACAYNIVFIPLAMGMLLPWNIHLHPMMAGLAMACSSVSVVINSLTLKFWTRPSLQDRRSNTVTLFDKVFKLWDAISARQMNIQKDGYQSVPIEMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9P6</accession>
    <name>I4Y9P6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959221.1">
        <property type="nucleotide sequence ID" value="XM_006959159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9P6"/>
    <dbReference type="GeneID" id="18472969"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57983"/>
    <dbReference type="HOGENOM" id="CLU_1154114_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9P6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27921" checksum="87A7E913C4E502E9" modified="2012-09-05" version="1" fragment="single">MPNKPKVTTNIQDLPPEVLPLIRLHLNGPRSNGNQRGMTANESSVFTGLLYYILERPIANSIVSVSISTYTYFDSDLQDHLRLISKLPRLEMLKIGPQSLRSALKSNLRFRTLKALMMDTVSFVAPPSLLRDRRQIFPKLATFFIESNNFVHWMTKKMGYMPNCIEKDNLHHVEQYWTDFIEDNGSSKPNYTKEVYEIFYRNEERLTLLWADSRKVCRTIKVSNVPLSILMPIVNSNTSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Q7</accession>
    <name>I4Y9Q7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959232.1">
        <property type="nucleotide sequence ID" value="XM_006959170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Q7"/>
    <dbReference type="FunCoup" id="I4Y9Q7">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Q7"/>
    <dbReference type="GeneID" id="18471624"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33140"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y9Q7"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="478" mass="55708" checksum="A93024492F99B6BA" modified="2012-09-05" version="1">MSDEEDFMMDEGDEDYDFDYEDDDEDVEQGEAGLENKYYLAKGKKEDNLDEAIVDFKYILDNEEEKGDWGFKALKQLTKLHFLRLRKFPEALEYYTQLLTYTKSAVTRNYSEKSINGILDYVSSDKATDQTVDLELMEKFYAVTMKTLAEMKNERLSVKTNLKLAKLWLDRREYARLTETLKELRSSCQSADGTDDQSKGSLLLEIFALEIQMYSHTNDTKKLREIYNQTSTVTSAISHPRVMGIIKECGGKMHMNEKSWEKAQTDFFESFRSYDEAGSMQRIQVLKYLVLAHMLMNSEIDPFDSQETKPYKENAEILPMTQLVSAYQHKEVHQAERIIAKNRKVIMEDPFICHFIDDVMRALRITYLVDLIKPYQRLELSYIAKQLNVTVAQVEDLLIELILDEKIKGTIDSVNQRLEINREPQLEKRRYEALTKWTNEMEKMHEMLVSKFSSISTNNNFGGPAGRLINPMMASQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Y1</accession>
    <name>I4Y9Y1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="9" type="ORF">WALSEDRAFT_60839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959298.1">
        <property type="nucleotide sequence ID" value="XM_006959236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Y1"/>
    <dbReference type="FunCoup" id="I4Y9Y1">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9Y1"/>
    <dbReference type="GeneID" id="18474198"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60839"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Y1"/>
    <dbReference type="OMA" id="YYERHFH"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="260" mass="29573" checksum="C6F0D3BDAC3B3986" modified="2012-09-05" version="1">MIPTISRLTKPAYPGHWPVGKLENLFLAAGSAVVSLVDVYRHDMLATLTETSTPTMLLQQMRQGMLSSDNGRRILAERPRISTKSVDLDALRDLPKGTLGREYSLWLERCGVTPDTRDPVHYIDDEELAYIVQRYRESHDLYHLLLGQRVDILSELIIKWFEFSHFKLPVAGLSSAFGPLRLRHSWQRQDLFTRSGPWAIRQGNRCAPLMGIYWENEWSTNLAELRQRMNLTDVPDWRDGKGPQGKGKAKFGSGLEIGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Y6</accession>
    <name>I4Y9Y6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959303.1">
        <property type="nucleotide sequence ID" value="XM_006959241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Y6"/>
    <dbReference type="STRING" id="671144.I4Y9Y6"/>
    <dbReference type="GeneID" id="18474201"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60843"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081931_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Y6"/>
    <dbReference type="OMA" id="FRTHWQC"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="155" mass="17787" checksum="F17142AFA99D1A39" modified="2012-09-05" version="1">MADHRDAVLNSKEFVESSPMPKDVPHVDELGVTSAPLKSASFFIGDKCKEYNDDFMLCKQENNNPEHCLKEGRKVTRCAASVISDINKHCFKQFESHFQCLEFNNQYFYPCRKQERSLNECVAASLNLHKNIPGTPEGQPQIHEKTNPIHKRVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA24</accession>
    <name>I4YA24_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_64979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959079.1">
        <property type="nucleotide sequence ID" value="XM_006959017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA24"/>
    <dbReference type="FunCoup" id="I4YA24">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA24"/>
    <dbReference type="GeneID" id="18474976"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64979"/>
    <dbReference type="eggNOG" id="KOG0121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070952_1_1_1"/>
    <dbReference type="InParanoid" id="I4YA24"/>
    <dbReference type="OMA" id="TKCASPE"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="175" mass="19952" checksum="3B29176C5272EF72" modified="2012-09-05" version="1">MSDVIQPLDGPSTYKDTRSRIDPEKQREMLERSTTLYCGNLSFYTTEEQIYELFARVASGQGIKRIIMGLDRNTKHPCGFAFVEYYSHQEAVEALRYINGTKLDERVIRCDLDAQGYKDGRQFGRGRSGGQVRDEYRQEYDSGRGGWGHLKGQVPSGDNGDQSYSNNSKKRNAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA64</accession>
    <name>I4YA64_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959117.1">
        <property type="nucleotide sequence ID" value="XM_006959055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA64"/>
    <dbReference type="GeneID" id="18475595"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69525"/>
    <dbReference type="HOGENOM" id="CLU_542066_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA64"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="503" mass="58948" checksum="EC3E7B29A4C3B4B4" modified="2012-09-05" version="1">MRIRLIQAYLRLGYKSLHHDNPHMNYLVFRPQRMRLQEERQSIGSLIIKFSLSESLSTRADFDDLISQYTNLSDVKDEIWYHFVFAGITNIENPLDYLAAENVRLNLSGGIEDVRGDIKKYGSYPLSLRKADLTRLFEWKKTLKDNIKFYHDKINGLMKLASLYKLPYNIAVEDYSELTAAHLTDNARELVKVFQKGSKCLNNFLRFLAQCYEDEGYVSYRKCLDWIETNQVTGWHGYNQNITDLLVTIEIVDDETRCEKLWEEYYEDREKKDFRMLEISKIQSEKLPQFTYRGSSKYRKRLETKAIDLYIDLKNALHPSLVLFYDLQLKQLAQMEVYVNQVKTLDNTAISHHLPMVADRALINKNMHAIKDLIGLIGNYIIRNSYTKPSKDTIREMMDDIRFQKDEDPNELVLKVLIILDFVDAPLERLDLLNQSHETKKERIAKINGIKRKNVSNAHEEGKEYVLEASSQDSISNEGEFPTTRSGRKRKSDNDQKGPKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAI2</accession>
    <name>I4YAI2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_46804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958965.1">
        <property type="nucleotide sequence ID" value="XM_006958903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAI2"/>
    <dbReference type="FunCoup" id="I4YAI2">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAI2"/>
    <dbReference type="GeneID" id="18472401"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46804"/>
    <dbReference type="eggNOG" id="KOG0113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045151_5_0_1"/>
    <dbReference type="InParanoid" id="I4YAI2"/>
    <dbReference type="OMA" id="GRTTKGW"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="324" mass="37103" checksum="8B8D97F9C168DF17" modified="2012-09-05" version="1">MTHLLPANLLKLFAPRPPLPYAKPLERDPTRSKSNAQSGIGEILHSLKEEQEDRRAKQNGILDEDIESNDLQVKLAEVYQVAIRKAERQKKRQENFKRALEHYKPTEDIEAIGDPFKTLFIARLSVETTESDLRKEFEVYGPIERVRIVRHKDTGKSRGYAFLIFEKERDMKAAYKDAEGLKIHGKRILVDVERGRTVKGWKPRRLGGGLGGKPKVVIPDIAPPRAPRGGGGFRGGPRRSEGGGRFGPPGGGRFGRDRDGPPRFDRDRSHGDRDRYGDRDRDRDRDRPMRQWGGPPRDPPRRSFGGFKREYEGGDDRDSKRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAZ3</accession>
    <name>I4YAZ3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_4034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958730.1">
        <property type="nucleotide sequence ID" value="XM_006958668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAZ3"/>
    <dbReference type="FunCoup" id="I4YAZ3">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAZ3"/>
    <dbReference type="GeneID" id="18472165"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_4034"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_4_0_1"/>
    <dbReference type="InParanoid" id="I4YAZ3"/>
    <dbReference type="OMA" id="ACMTAKC"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="254" mass="29451" checksum="2E1446E6D494A348" modified="2012-09-05" version="1" fragment="single">LPSVPLKPFKNQVGGHHPIFRFSRRAVCKPLVRRENQFYESIERDHPLLLQYIPQYLGTNNCRTSSRLEQFLLMEDLTGRLKAPCVLDLKMGTRQYGVDATEDKKASQRKKAKKTTSHSLGLRLCGTQVYNVRKNEYTFQDKYFGRNVQANNFTESLSAFLYNGERILVHHIPDILAKLYKLARIISRLDGYRFYASSLLFLYDGDAKIQRRLSESFRGYNAKVDLDTGMLYARYPPKHPTEPDYGYLIGLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB03</accession>
    <name>I4YB03_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cwf21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_54726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958819.1">
        <property type="nucleotide sequence ID" value="XM_006958757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB03"/>
    <dbReference type="STRING" id="671144.I4YB03"/>
    <dbReference type="GeneID" id="18472690"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54726"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058463_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB03"/>
    <dbReference type="OMA" id="LAHMRPR"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="263" mass="30999" checksum="AEDF836ABD4380DA" modified="2012-09-05" version="1">MADIVKEYNGIGLPSARGSGTNGYIQRNLAYIKPREQQSTYKEEISARSRSPDRSILEHEQKRKVEIAVLELKDDLEEKGVPEGEIEDKADALRQQLLAKPVSATSNKQFKGHERHAIAAAKALEMQRINHAFGTRGNYKEGDAFDRELQERKRIERIERREHHEVEKIQRERDARERSRRQVERELDERERYRRRSPSYEDGRRRSPSYDSRDRSRSPPRRRSDSPYYNDRRSYSPRPRSRSPSYSRSPSPRRESDLSPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBA3</accession>
    <name>I4YBA3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958600.1">
        <property type="nucleotide sequence ID" value="XM_006958538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBA3"/>
    <dbReference type="STRING" id="671144.I4YBA3"/>
    <dbReference type="GeneID" id="18473983"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60493"/>
    <dbReference type="eggNOG" id="ENOG502QPZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510195_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBA3"/>
    <dbReference type="OMA" id="LEMHDEN"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="534" mass="60661" checksum="2E185840BBC358A3" modified="2012-09-05" version="1">MKNGLILDKLPNELIIDIIMLLPINDLSQLACVCRTLNDVIKKHRNLIYHTKSIEYGFTDIHSDIDNVYSVANKRRCLRKTFEKVNDWRDYCFLSLQQNERWPSQCNDSRGIDLHLPRDRSVWRIKVDTNLKIFIYTSTMGGLSIKSIENPHEFRCCNTSVAPFAHLEYDNGYASTHGASLDLWKIRLEGNLPKLEHITRVSVPFETRASRMKFGVLAVASADGAHIALINPSDGSLIKVINTVRVVLGVPLMIFYIEQTQNEVLICRGSKIEVYSKQTGLLCTTIRITINPDQFYCLSKVQFGGLQGDEPVSGIAPTFQEFQIAKRHEIDEDEDNLTAQVRADMFAYFGINRPAANNEDQANIVQENPVELDDERDNPVGEDVEERDLVQALMHEFEDNWSAVHVDGDTLVALSEKQILIVPNYSKAIEDDEMLNKQMVIKLPEYDGDTSQMCFEYSRMVFELEGHLCILPLHDTPQVMYISESAAPDSASAMQATEDAIISTIHENDNHSHWPHIQTIRWIDFSPTSATLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD9</accession>
    <name>I4YBD9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_46278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958634.1">
        <property type="nucleotide sequence ID" value="XM_006958572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD9"/>
    <dbReference type="FunCoup" id="I4YBD9">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBD9"/>
    <dbReference type="GeneID" id="18472381"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46278"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_4_0_1"/>
    <dbReference type="InParanoid" id="I4YBD9"/>
    <dbReference type="OMA" id="YYNNIVT"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="465" mass="53916" checksum="6A87704157A216DA" modified="2012-09-05" version="1">MSLIRTESSYISNKTKPATPQFAIESFRRLVRSLLVSEKPIIDDVRKEWIDKWPGKCDDIRYFFFKETISLLREFDIKNESRPKYLTANVLSILENIHTMPTDQSEIDEFWVPEIARQEKEQVKQSNLEQTKLDSQDWTAYYDQMVTEEDEEKATDKNAKKSKVRDTINLSAHRAMYSGVWLTLLKCPTGLDVSENRRALVVLHQLVIPFLKPSERASLADWLSDCCDIGGVNALLALNSLWRLMRDHNLDYPDFYRRLYALCDRNVLHVLYRARFFRMLDLFLSSTHLPALLVAAFIKRLSRLSISASPAAIVMLIPFTYNLLKRHPGCMHLIHSERMAQGEEADMYKVEETDPMLSNALDSSLWEMSTHQSHYHSSVNRMSQIFSQVFSKPNFAMEEFLDHAYITMFDSEIRRRIKNNPALYDGKTIGIFGGHKRKLDSLETDEEKDAVSGTQGDLVAELFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBW6</accession>
    <name>I4YBW6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958488.1">
        <property type="nucleotide sequence ID" value="XM_006958426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBW6"/>
    <dbReference type="GeneID" id="18472924"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57525"/>
    <dbReference type="eggNOG" id="ENOG502SCUA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641243_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBW6"/>
    <dbReference type="OMA" id="WSYEPIY"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47131" checksum="23B57F9196EFB106" modified="2012-09-05" version="1">MRIDDLNLDIYHDLAGYLTVDQIVALRSCSKQLLALADDVFAVGYLSRNKRKVYYEREDSDLNRMLRQDFIDTNWASMHFHSTQLLSTQSSIPVLVTHKHLLILGSRSAVFVWDRRCSRYIRFVIANNKASFDITGLVVVEYVGNTVTLITSHVAGLIQRVVLDLHTRKARQSAIYTPGKPITEVNRTRNVRTLQGNAENVISAGEIGTLSIYKPKTPWLQPETVNVNTTRLWGIDANYVNNSVAASHNYSHTTRSSISLFNLNQTRIDNAGVLNTPDNVSSFTITNGHTTNGVLASPDILIGGFYDSTVRIYDLRTGYNQVASYEDGLDIQPVYSLDVGGGHDSYICAGSALYSRLRVIDARMTGDFAHHIFAAHSSERSSPVYQLKVSHSHCYIATDSKVHELDFSRRNAHSQFPSIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC08</accession>
    <name>I4YC08_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_60466</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958529.1">
        <property type="nucleotide sequence ID" value="XM_006958467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC08"/>
    <dbReference type="FunCoup" id="I4YC08">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC08"/>
    <dbReference type="GeneID" id="18473964"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60466"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_0_1_1"/>
    <dbReference type="InParanoid" id="I4YC08"/>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
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        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM21500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="231" mass="25148" checksum="233494E176344E47" modified="2012-09-05" version="1">MCGGSSCLQSIIAPSALASDFGKLASECQRVLDDGADWLHMDVMDGHFVPNITMGAPVLEWVKKAIPDIKMDCHMMVANPLQWVEPVAKAGGYQYTFHYEATDDHMAVIKEIKKHGMRAAIALNPSTPASVLSDELIAQLDMVLVMTVWPGKGGQKFMPEQMPKLRNLRERYAKLDLQVDGGVGPKTIDECTQSGANVAVAGTAVFGAQDVKQAILDMRKSIDGQIAKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCL8</accession>
    <name>I4YCL8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958394.1">
        <property type="nucleotide sequence ID" value="XM_006958332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCL8"/>
    <dbReference type="STRING" id="671144.I4YCL8"/>
    <dbReference type="GeneID" id="18471523"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32582"/>
    <dbReference type="eggNOG" id="ENOG502S5XC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752736_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCL8"/>
    <dbReference type="OMA" id="ANARICD"/>
    <dbReference type="OrthoDB" id="3353364at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="376" mass="41704" checksum="61C77BF90B41D050" modified="2012-09-05" version="1">MADAATEISPELDLARYQITALRAYAVAALAILLWDYATTVHLEYRRIWKAPWSIVKVLFFITRYSAIACVTIIVFGFHYQYLSDTQCQTYAKMEPVLCVITVASTEAILLIRVWALWGKKIYVLIPLLFCLIVEAAIMFAAAALYVPVEFKPGLGKLEQGCISTGVHPLTTAYWIVPLIFDAIVVVMTVTKLAMNRNGSRSKIAKVFLRDGLMYFSVIFGINLINTVVYLVTPENIKAANSTLAIALTAIMGCRLVLSLRALDDTSGGSSTSRDRSNSRGPGPVVTIGGTNRRGNVSQPQTTTFGSYKMNEFSTDFVGTLADVNEEQLNHHGQGSYNTEDKDDESLYRSEQPRNAFNPFDPVKIQVQHQTEHHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN0</accession>
    <name>I4YCN0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958405.1">
        <property type="nucleotide sequence ID" value="XM_006958343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN0"/>
    <dbReference type="GeneID" id="18473927"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60394"/>
    <dbReference type="HOGENOM" id="CLU_2470792_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCN0"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697989" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="88" mass="10034" checksum="35AF149F0D311F20" modified="2012-09-05" version="1">MGCNSKLSSFKKLGLFMWLSYICLVVVDAAETSSRSDFLQNRPDKGLFYFHNATGNFVVDKDGNCFDTTRLMMDDAAFDVDEWYPVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP7</accession>
    <name>I4YCP7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958050.1">
        <property type="nucleotide sequence ID" value="XM_006957988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP7"/>
    <dbReference type="FunCoup" id="I4YCP7">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCP7"/>
    <dbReference type="GeneID" id="18473821"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60221"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="InParanoid" id="I4YCP7"/>
    <dbReference type="OMA" id="DFHALWC"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="109" mass="11961" checksum="B0BAB5C50981B15B" modified="2012-09-05" version="1">MTEIVHVKDLEQFKTLVGSSKPTIVKAEAEWCGPCKMIAPIVKKLADATPQVQFISFDVDEASDIAEALSIRSMPTFFLYKSGEKIDQFSGATPPQVQAFVKKAAELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT5</accession>
    <name>I4YCT5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_17978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958021.1">
        <property type="nucleotide sequence ID" value="XM_006957959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT5"/>
    <dbReference type="FunCoup" id="I4YCT5">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCT5"/>
    <dbReference type="GeneID" id="18470748"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17978"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001499_4_2_1"/>
    <dbReference type="InParanoid" id="I4YCT5"/>
    <dbReference type="OMA" id="KMNIPHY"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="596" mass="66326" checksum="CA83EEAD89825B38" modified="2012-09-05" version="1">MEDGQSEAQQPQTEPQPFDAPGVSYSSQDAPQDDFKEEVHDQSQPVVPPTPAGIEPIVLSNGTKLPPRSAAFGIPAGPPFSFNQLKFVSSLVKQLKKMKAAVPFLSPVDYISMGIPHYPEVISEPSDLGTVDRKVQKTIKAEEGGYYNFNDWETDVRRIFRNTEWFNGHEHPVSKMGKQVEESFDKQLKKMPPSTNDAVPSTSRGRGAPRRSQETGRPRREVHHPAMTQNDPNRSKRRKTTAYGRNGTADQMRHCAYILKELHKKVHSSYASPFYDPVDYIALGLPDYPQVVQQPMDLSTVGQKLNLGDYEGPSDFFGDMKLMFGNCYKYNPPGTPVHEAGRQTEAVFDEKWTQLPPLSTPLEISDDENSDAVKALQRQIEDMQKSLTDIKKKGTGAPERVSTGGGGSGRGGKRGSTGGQVGRPRRKSYDEDDENYQIPEITFDMKKELAGKIQQLEGDQLDKAIKIIYETLDLDNNSDEIELDIDVLPVKTLQKLYMFVVKPQKQKRGPYNKQHVDVDLQPRPPKRAGTGGVKRKSMNEDEEALKIQALEAKLKSFEGVTDIQLNQPTTIPENDEASSGSDSDSVVSEDSGSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT8</accession>
    <name>I4YCT8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_64011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958087.1">
        <property type="nucleotide sequence ID" value="XM_006958025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT8"/>
    <dbReference type="GeneID" id="18474891"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64011"/>
    <dbReference type="HOGENOM" id="CLU_1031348_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCT8"/>
    <dbReference type="OMA" id="WHESFST"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26216" checksum="2FBFB5D48687526D" modified="2012-09-05" version="1">MASTEGLSEAQLRAQKRQERLLAKSSDRLARLTGGSNDRVVSDLPQKATKSTETNTPPKVVASDDPDDVDLAKVEQIANQENDEVANEAAFQTLLQKRSDDIPTVPSLEELLAQQPTTPSRVEDSNKNARLLAIIRVFRVISVISLTVFAVMHSSLLPWHESFSVLASADPEKRLQEGSAAGIEFFPLWSTLLPLQIFFYVLTSHLSPPSNRLPKLPGWMTALLDSPLVPEYISFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCX8</accession>
    <name>I4YCX8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32392</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958122.1">
        <property type="nucleotide sequence ID" value="XM_006958060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCX8"/>
    <dbReference type="FunCoup" id="I4YCX8">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCX8"/>
    <dbReference type="GeneID" id="18471481"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32392"/>
    <dbReference type="eggNOG" id="KOG1355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_3_0_1"/>
    <dbReference type="InParanoid" id="I4YCX8"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="317"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="431"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="445" mass="49052" checksum="E04BF81CB19BC50E" modified="2012-09-05" version="1">MSTATKTAKVELSRAKANVILGAQWGDEGKGKLVDILAHDVDVDARCAGGNNAGHTIVVEDFPTPDGPKKQKFDFHLLPSGLVNEKCVGLIGNGVVVHVPSFFEELQQLINKGLNCADRLFISDRAQVVFDFHQIVDGLKEVELGGSSIGTTKKGIGPAYSSKASRSGLRIHHLYDDDFEHKFRKIVEGRFKRYGTFEYDTEAEIKRYKELAERLRPHIVDGVAFIHNALNNNKKVLVEGANALMLDIDFGTYPFVTSSSTSIGGVCTGLGIPPGRVGEVYGVVKAYTTRVGGGPFPSEQLNDVGVHLQEVGAEYGVTTGRRRRTGWLDLVVMQYSHMINGYTQLNITKLDVLDQLKEIKIAVAYHLDGKKLDSFPADLKLLEKVEVEYATLPGWETDISKCRQWNDLPENARKYIEFIEQYLGVPVTSIGVGAGRSDMVLKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD18</accession>
    <name>I4YD18_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958161.1">
        <property type="nucleotide sequence ID" value="XM_006958099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD18"/>
    <dbReference type="FunCoup" id="I4YD18">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD18"/>
    <dbReference type="GeneID" id="18472902"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57330"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD18"/>
    <dbReference type="OMA" id="LFIVHYL"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="760" mass="84779" checksum="11896DE2C47B1F6B" modified="2012-09-05" version="1">MQSILNRFTNNSKINFRLSDSGINRLKLELVQLDDTDYWSRYWTESLDDLITKADLLAAIPQNIHSLLYRLTDKLNSMLYAPTSKLVEPAECLNIYKLLVKILTVYYESDRFDGVSKLSYNDQPLLQSLLWALVDSLYAIGLTVPDEYILPPGQAPTAINHLIWAKGVGSSTSITSNSSLDTNKAIILSTILAVLGPGLFSSHQDLLQVQSSIAKPLSSLNRKTTLTLLASLINQSFAEYSFRFTQVTVEESNLSLLSLDLLLLLLNDDGSTFSKSLSKLHRQQDFDFILTRSLEIIDQNNANDNSSAIKYGFQTVAQSTGKRSMKSPSNVQLWLFLWRCYHLNTKFAIYLSQHGHYHPIATRLLNTLNYVKDKKQDSTLVTLLVSFLQTLSVNQDFGKALDSPISFTDGSSTLSDLLVNTTYSVLTANVHPASYSPIMASLSNLSIYLKHLSQLSAVRLLAIYRALASPHFLFADKGNPRYLFYMLDIFNGIIYEQLNNNPNVIYAILLNSESLQALATLTLQKGLSMIEGSRISSLDYGNATTSGNNKLSYPPQRSISTPLTNYQMSEKAKGKQAEHLRTASQMSDPGNDKKINFIGDVPGTICGYKTMIKNDTPFVATEDWVMSWVATLPLDAILLAVTELLPIIKKEMSNSSALAELRNANISQELGNHNKTLDNFKWTEAWMIWRTIAIWSSAYINAIQNWSSTSVKLFGVTHQEGIRQQINKQVGIVANNVGISRFLSVGNGRPSQNRSTTGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD75</accession>
    <name>I4YD75_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_38048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958211.1">
        <property type="nucleotide sequence ID" value="XM_006958149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD75"/>
    <dbReference type="STRING" id="671144.I4YD75"/>
    <dbReference type="GeneID" id="18472044"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38048"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008722_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD75"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="487"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="574" mass="65255" checksum="B8A4F3D795CB6EF1" modified="2012-09-05" version="1">MQENLSVTEEILEEPPSRRANGTLTADPSGTHLWLIGGDYYDGHRLHTYHNVYRFDPNKGDKGEWREYKSKNAPAPRSAHQTVATAQGGGKLWLFGGEFAGHSTFYHFSDFWSFDIQSKEWERIDTKVRPSARSGHRMTVFKNFIILYGGFHDTGVRTTYLDDLWIFSLDDFKWRKIEFSPLERKPSARSGFSFLPCPEQNEVVVFGGFCKTYEKGKRPVAKSLDDCYALKITTDEKNNTIFKWDRRKKVGYVPSLRSGATMAYWQSKNMGVLFAGVSDIDDSEESLQSVFHNDLFGYNLLGGGKWQSLNLRKPKKAGTKKKAAKKRAAKAAATAESDSDKGGESGSEDEQQPQQPEEEVIIDDPQKTVPMPRYNAMLAILRNTLFVFGGIFEQGTQEFTLDDMHSLALDKLERFKCIQECNVVGIEDEQDDDDEDDDDDGEEDYEDEEGTLEKGTDKQENLAETQVEPNEQPEEATQENPSDPNQDEGLPQPGETLRQFFERTKDRWVEVALQKMPEAQAKELRGVAFNLAEEKYEEHKPILREIEAMIRESGAEPIAAKSQQQPGSTSRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD80</accession>
    <name>I4YD80_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958215.1">
        <property type="nucleotide sequence ID" value="XM_006958153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD80"/>
    <dbReference type="FunCoup" id="I4YD80">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD80"/>
    <dbReference type="GeneID" id="18473873"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60302"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_7_1_1"/>
    <dbReference type="InParanoid" id="I4YD80"/>
    <dbReference type="OMA" id="KEISHAN"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="152" mass="16772" checksum="894BE40982AC0465" modified="2012-09-05" version="1">MQAAAAQPKRNLRKSKDQESNGIDNFELPKSTVTKLAKEGVPDGIKFQKDTLLALQKSSSVFINYLASAAQEKAHDKSNKTVNAAHILAAVKELDIGTQKGELEEILNEELKAYKTIQETKAANKTQQQIEKEDNAAETNNPDEFDESVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD84</accession>
    <name>I4YD84_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958218.1">
        <property type="nucleotide sequence ID" value="XM_006958156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD84"/>
    <dbReference type="GeneID" id="18475478"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68827"/>
    <dbReference type="HOGENOM" id="CLU_536608_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD84"/>
    <dbReference type="OMA" id="GWNYIAT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="535" mass="58609" checksum="3B9F312C836DAEA7" modified="2012-09-05" version="1">MGPAQNNKISERIQALQQSSQYPNNKEAKNKPIDTKLSVKGRAARFSQFDTGKPLEPINYNTLNDNKQRQIIGNRIPRASTGGNPSIAVIPRDVEKKQRRRSEDISMLDSSRLSIMSDQSSQSVPAGVLADANTPSMPTSNMLRANSAILAELMSKGEADNGELNKKVVEDASGSGTCTVVSSSRSPTPKLDEEPQDEVQENVAEGNISSGASSVTTPKESVATPRASNVATPVASPQPIKANPVPSLVVVPPRDTSKTSVRREREERTNHDENDNDNGWKYIATNKARKSQPPPEEDPVAMDFGPSMPLDERFNFISLTEPNAISKLEPKLNESGISGNIPDQQQTKPGSHKSRVSTSDSIALSQADSTKSTFKSSMGRIFKGKKIFGKRRKTLEGVQSPAIEVPPLPTSFSQTLPALRSIEPMNINLPTAEEIERREEEARQLKEAEERRKKEREEEQARNRKIQENRIRELKEAGRSKSSLGASKVSPKAAPKEKPKEVPKNTTPAPAPATPEPEFTIEDADWATAVINQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDA0</accession>
    <name>I4YDA0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Timeless-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957754.1">
        <property type="nucleotide sequence ID" value="XM_006957692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDA0"/>
    <dbReference type="FunCoup" id="I4YDA0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDA0"/>
    <dbReference type="GeneID" id="18473740"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60100"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004294_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDA0"/>
    <dbReference type="OMA" id="MEHYYEM"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="890" mass="102390" checksum="D35E816BD5F26DA0" modified="2012-09-05" version="1">MSDSEDEGGYIDLRELYSEPIISRISAVGGIEATKLADGSLSQEYKLGDECLGCLKDLKKFWRKDDDDPNRTVARILHKSNVLINDLLPVLALSVNRGAAGDRIALAATDLISCLTWPISIEEEFKELVDREEEHKVANFEYTSFIQAQQAYKLAIVKNKTVQHFLEVLLPRLAKSRLERTQRDDQVVALILHTFRNILAIKDTDAHPNLQSELIEQMHSFEILSLFNTLASSSDQRELINYNVVVLEIFHSIFRGIRADDLTLDPTKASSAGLSNLLEVESKQKRLNSRSNTSRHSRFGTTVSVLSGSNRFVQSRQSAITATGDQSMDVGKKKVFKRAKDQDNSGEVHLSNNARKHLKELAETFIETSYDTFFTTLLKDFRMERPKIRETDKARWFSLSAFFLEFFNTKWRRKDISKIPEAEIEKAVGSVSCMVDPTTVGYVSARMALTVDDKPPSWKELHCAINCLIQILLLVDEMVRCTQAPGIVEIAEVLQDKLYYSGDVMDVVVMVMGRYKDQSIKFLESIVHLAYVFLRMLEKFSKSKAYMFVRKRKSSKRRGADDMNEPNMQTTAEEEAEFQRDTPSVAEHKFMFSSYERRFATETIVKTCLSYLERHLEFHSLDQLKHVVNLLYRQSVRAQGEELFYKVSTLNTFRIVQEQVVKSAVNYHSGPYKDLMKLIEFILKKFFKAATENPMLYVEALFPIRSHTRSKGTIEQEDDRKTGLSDDDDNNNKFDPEFPDAAQTSANKRKKRSRRRSENGEQVERTARQEQMQSYLSAKFIEDSDEDEESLQEFFKKEEELRDRANKAAQVSEVPDESLSLVARRRKVREVEHEIQIVPETQDKQDNQDNQELITQRSQSSPHFDDEDAGISQTKLVAKRRRMIDSDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDC5</accession>
    <name>I4YDC5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIP41-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957777.1">
        <property type="nucleotide sequence ID" value="XM_006957715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDC5"/>
    <dbReference type="STRING" id="671144.I4YDC5"/>
    <dbReference type="GeneID" id="18475403"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68466"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592121_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDC5"/>
    <dbReference type="OMA" id="EMDEWEY"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52246" checksum="8C822ED92BA5E981" modified="2012-09-05" version="1">MSYPQEGLIEGFNVGDFTFNLISGPAASDDDLLGFKEDLGFDPPMLLFPHNAIKIAHNLSNFTLAFYARPALHLIDKSGAEAKRVAYAFNEGAHAQLPKKSHDWTYTTTYSGNSTRSFNGTPYRSIASTPSHSHNLADNVISHHTLTFFEDDLGSAGYTTLRATLIVYDDSFEILQRHFLRVNNILFRIFDCTFSHKFGSWEINKHCRGWEGRWNEVFMRLPTDYQNINETSSEYQDAVKDVLVLLSPLESIRRAKELSPSNQMLRSTSGDSVSSASMSSRSGSRIGFAARVLLSRHNSHNSTASTRRRRKHPPGALSFSTAKAKSNPGSMPSSCVSPMSSGCCSPSAISGAGTGWNGVGRWSYRIHLSDMNDEFRRELPSQFPPENTDENYEMDDWEYERRRSFAYNNMFNDFSSCSSSDDDGYAYDQMDVAQQLTKRLERFSRQYPERLVDRDDYDNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE6</accession>
    <name>I4YDE6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957798.1">
        <property type="nucleotide sequence ID" value="XM_006957736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE6"/>
    <dbReference type="GeneID" id="18475409"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68482"/>
    <dbReference type="eggNOG" id="ENOG502S6Z8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151392_1_0_1"/>
    <dbReference type="InParanoid" id="I4YDE6"/>
    <dbReference type="OMA" id="NKEVGKW"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="74" mass="8221" checksum="9CF6D7D7D4087414" modified="2012-09-05" version="1">MFGLGKLTHYAFDAVLISIALAGVKRSTGLTLAINRMANKDARKIIKSWLDLGEYCFDGAVILMQRSKSFIRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE9</accession>
    <name>I4YDE9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_37442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957801.1">
        <property type="nucleotide sequence ID" value="XM_006957739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE9"/>
    <dbReference type="FunCoup" id="I4YDE9">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDE9"/>
    <dbReference type="GeneID" id="18472015"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37442"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="InParanoid" id="I4YDE9"/>
    <dbReference type="OMA" id="GLMPINS"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="392"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="637" mass="71141" checksum="43D51A06B4741E58" modified="2012-09-05" version="1">MKIVEKINESKDNKTPFFSLEFFPPKTDQGFVNLKSRLQRLSLLKPGFVSVTWGAGGSTDERSLELAAVARDLGLDVLLHLTCTNMEKSRLSWALDKAKELGIDNILALRGDPPRGHEYWVESDKNLSHSSDLVKFIRDNYADNFCIGVGAYPESHKDSSDAAQDLKYLKLKQDLGADFVITQLFYDSDAYLNWLDKCLDIGIKIPIIPGIMPIQNVPSLRRLANLCGAHIPSVISDHLEPIKNDDALVKDYGVELSTSMVRQLIDKTNSQKEKYGNLAISAAHFCTLNLEKSVRRILANLDWSSGLDASSLEPNGLTHNTTTGAVEPARLGNRLVAENGISHGHTADGPPPLSITAHEAAVRALHALKHHPPSEDSGLPSSNKTSSGGNSLWDEFPNGRYGDIRSPAYGELDGWGASLKLSSQNALKQWGYPVEVSDINEIFKKYINGQVASLPWFEENLDPESNSIKDYLFRLAEKGWWTVGSQPAVDAVESSDQIFGFGPKNGWIFQKAFVEFWVPEHELEGLCKRLDGWKDGGYYAGNAKGEMKTNFYEDTINAVTWGIFPGQEVVQTTIIEDVSFNAWREEAFEIWLEWSMLYSPKSASQQLMKNVHDNYWLVSVVHHDYKDTNGLWEFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE20</accession>
    <name>I4YE20_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_63950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958007.1">
        <property type="nucleotide sequence ID" value="XM_006957945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE20"/>
    <dbReference type="FunCoup" id="I4YE20">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE20"/>
    <dbReference type="GeneID" id="18474882"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63950"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028734_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE20"/>
    <dbReference type="OMA" id="DMADNTC"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="326"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="644" mass="70456" checksum="BA5C7082F5A0853B" modified="2012-09-05" version="1">MLRTVIIKMSFPVDLSKFKQLKLDYTRSTLSEQERSDLLSNINIFRDAIVAFSATGNARGVSGHTGGPFDTAPEVCILLALINANPEKFIDTFFDEAGHRVATQYLLSTLDGHIDPEHLLNYREANSKLPGHPELGLTPGVKFSSGRLGHMWAMINGVALANKDKNVIMLGSDGSQQEGDDAEAARLAVAQNLNVKLFIDDNDVTISGHPSDYMKGYSVQKTLEGHGLKVVRAEGENIDSLFKAVCEVVAHDGPAAVVASRKIAPEIEGIEGESHAHDVIPVAVAKKYLTKRGYTEEQLKFYDDIKPKSVKYDYKGVTADKGANRVIFGDAVNLVLDKLSKEEAAKRVMVIDSDLEGSTGLKGIHKAHPEVFVPSGVMERGNFSAAAGFGFGGNGERQGVFSTFSAFLEMCLSEMTMARLNHCNVLCHFSHSGVDEMADNTCHFGLNHFFADNGLEDTAPTSLYFPADGEQMKAIVQTIFWDQGIRIVFSTRSKVPYILKQGTQEQLYGGDYKFVPGKEEIVRTGSAGYVISFGDMLYRSLDAVERLREQGIDVGLINKPTLNVVDEETLKVYGSSPFVLVVESISQKNGLGSKLGTQLIQRGFTPKYKHIGTFHEGCGGIADQIPYQKLHPADIEAEIRKLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE24</accession>
    <name>I4YE24_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958011.1">
        <property type="nucleotide sequence ID" value="XM_006957949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE24"/>
    <dbReference type="GeneID" id="18473815"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60210"/>
    <dbReference type="HOGENOM" id="CLU_1939729_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE24"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="130" mass="15381" checksum="B481BD76324036A1" modified="2012-09-05" version="1">MIEQLRVIEALTLKKYENSTITVEKRSNSLRKHVLLKHSLETLDEFRCGLYQQPRIIKREPEEQRRKSLTKVQIKHFDKLDPVVEAKQCEYYDEESDSDSDSSEENESDSDDDDFDSVSSMYKSHQVEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEB4</accession>
    <name>I4YEB4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957563.1">
        <property type="nucleotide sequence ID" value="XM_006957501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEB4"/>
    <dbReference type="FunCoup" id="I4YEB4">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEB4"/>
    <dbReference type="GeneID" id="18471408"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32018"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEB4"/>
    <dbReference type="OMA" id="GYYYHRQ"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30507" checksum="ACD46C688E68BFF2" modified="2012-09-05" version="1">MPIQHSTELTLTKSLQPKLSQNSKRLKRRSSSELITNDVAVPTKQQKISHESIDPFIDITRLRIPSTPLGCLSPGASFKGIQRSGWQSYHVKVDIQDVSITNSQASGYLTIDGLTRNQPTITTFFTAEIIGNKYGFRTSKYDATASDDLRHWSKFEAFKRITKKDDNKMTYDLLKDFTHTRAIFMRWKEHFCVPDSSIKDIPGASFDGFYYVCIDLDCPPTSLSNCHPSVPSSGPHLSGYYFHPHSEPFQELNLRELPKTTSDTFEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEU8</accession>
    <name>I4YEU8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_54186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957730.1">
        <property type="nucleotide sequence ID" value="XM_006957668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEU8"/>
    <dbReference type="STRING" id="671144.I4YEU8"/>
    <dbReference type="GeneID" id="18472651"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54186"/>
    <dbReference type="eggNOG" id="KOG2396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026025_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEU8"/>
    <dbReference type="OMA" id="WELNINI"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="640" mass="73209" checksum="11CAD8B8242B7171" modified="2012-09-05" version="1">MANVTMAMEQMLPEFKDYEKKNLFTKLEIKSIAAKRKNFETSLGRKTPSQSDYLKYIEYEITLENLKRKRMSRLKVALTPSPALYGIQKRILSLFDKATRKFRGDISLWVKYIEYLKKIGANKLLTRTFSTVINLHPSNPQLYILAASWELHNNVSAHSARTLLQRGLRLNTTDLDLWLAYARMELVFAERVRRRLEFDQQFQENEEKDSDDGVERQLDPEGELNSNKNLNIRAPDSDKKVMDGAIIEAIIDNARSSLKVQSQLPFFSSLISMLREFPLPITVKHSLLNHTYHTLRLTLPEDPEARLMIAIRPDSNAPEEAGVLDKVEGLKVACNAVTTVMAELQLPQMSEMGLQWLVHRHDNEEEENLKQYINHFIITSFKTSKSRKLLTAGAYLNYIEYLRRSSEAEEKVFKLVNDGLAKHSNSSQLHLLKLELQPSKEAYKEALRLCPTTWELYEGYLFFSLNDDPEGVLKVFETLIADSLHGAALIEANANAVSEGKLTIHDKLLRRFIEINSSHNIVQLSPRQLFPSSFVISPSPGFYEYILSSDIELNENLVDDLYRAWREHPFSDTVVITLKTIKWLLSIKKNSTAFNLFNSALTGLTDVRDKVQLESGWQALLGGDSSNNQSGEDVDTAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEU9</accession>
    <name>I4YEU9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_37348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957731.1">
        <property type="nucleotide sequence ID" value="XM_006957669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEU9"/>
    <dbReference type="FunCoup" id="I4YEU9">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEU9"/>
    <dbReference type="GeneID" id="18472009"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37348"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="I4YEU9"/>
    <dbReference type="OMA" id="GPKFEAK"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="351" mass="38179" checksum="E23CAA1296FBCAD9" modified="2012-09-05" version="1">MKGLIITGTRKAEVLEIEKPVLTGHNNVLVEVYSVAQNPPDSFSLYGSPGKPGNLLGSDFAGVVVESKSDKIKVGDRVCGMVSGNHSASQGAFAEYVAINVDMCIKIPDEMTFTNASTLGMSLYTAVQALFLKSPFALDPSHTQNILIWGASTAVGMYAVQLARKSGVNVVATTSSKNSDLVKSLGANLLFDYADVDVVDKIKQATNDNVTFALDCVGYPDSLHKSIISVSDTKPAIVHTLLPPQKDFPLNKTNAQVKFSLIHSVFAEDLSWANYIFNPPITQTEMDEEQEKAAKFFNYDKGTLYEPISNNEIKTTPIFATSRGLDNILPWLLKMERGEIRGGKVIHVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFE8</accession>
    <name>I4YFE8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957354.1">
        <property type="nucleotide sequence ID" value="XM_006957292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFE8"/>
    <dbReference type="STRING" id="671144.I4YFE8"/>
    <dbReference type="GeneID" id="18472866"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56851"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700583_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFE8"/>
    <dbReference type="OMA" id="PTRYYER"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="1">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="401" mass="46038" checksum="396657E2CB9FCB80" modified="2012-09-05" version="1">MAPFILNPHTVSGLRQNARVESDAPDGTPLYDLDQLVNYTVKEKQIDGISFEPTEPILEDNKEKLLDKPVQPLGFEYTDSNMLSFESITAQVLEDHQKVKDKMRDYMIIRNQARNQKIEALQDDYMTLQIDWEARCNKDIKIASAPQMPNKRSRRGDAVVHVELTNRRNANMSRKPASAVPQHVVAEATPTPPAESSEMEVTDSSSVFDKAVQEAEPLHLVDENSKEEMENEKVLSRMLQRLQAIDKKDPHVKAERTQAHIPNQELSSIDRWSCAYNDANARVLDPISYFERSHESEFWSEDEKEIFLKAYVDTPKSFAEIAEKIPNKSVQDCVLFYYMNKKVRVDYEKCHYRFKGLSFTRRGVMRRGKRNRKGGALLADISTTQSREQKTVPSAPHHLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFK1</accession>
    <name>I4YFK1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957401.1">
        <property type="nucleotide sequence ID" value="XM_006957339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFK1"/>
    <dbReference type="GeneID" id="18472868"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56878"/>
    <dbReference type="HOGENOM" id="CLU_520311_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFK1"/>
    <dbReference type="OMA" id="RECIADL"/>
    <dbReference type="OrthoDB" id="10671720at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="524" mass="58214" checksum="698EAB5C027AFD3C" modified="2012-09-05" version="1" fragment="single">MSTTTTTSDDKSFKSAKSTYNNYLLNFNFNSKYVKTSVEELVDIPTLSKSIEKSVEKRRLRNLNRKNHNKGAIEFRNLDSPLSSSLESEKLIPIHTRQRTQSDSVSNNSLIYKLNHIKPISTEDLMFRIKPKSVSTDDIIYSSLKSESVDVKDNNSVDFRHDILYKAINASFGDENTPTNKSKSNFLNTDPFNGNSSSSRHRHASTTSTRTPQMTRRKSSLSLSRPKPTISVDVNHVNHIDFPIGTGSAVDVKPITLNPLPVSNNTTAYQKRTSTIRKSLSTPLLSEQDNNVLESPPLPILSRQLSKKTSHSSIPNLKSSTIERRNKPPALELYQSTHKEVDNKLKGRQEHHRQDYNLLSPDTNKSTHNSSATQGQMQLSQGMNSNSWATGISSETYFARPSQANQIMNGLRNKLSNLPKLTRMRAETLPSPSPTTPNSFDPVYANGVGVAVYGYGGGFGNGGYGYNKSAGGSSKSPNRLKQRPSSSPTFPTNSNSSYSVARLKGMLEQHVAQERNMWHTIASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN3</accession>
    <name>I4YFN3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_56899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957431.1">
        <property type="nucleotide sequence ID" value="XM_006957369.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YFN3">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFN3"/>
    <dbReference type="GeneID" id="18472869"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56899"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_5_2_1"/>
    <dbReference type="InParanoid" id="I4YFN3"/>
    <dbReference type="OMA" id="LMELINM"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19517">
        <property type="entry name" value="RecA-like_Yta7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="400"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="957"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="968"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1446" mass="164110" checksum="2948E29510925C3C" modified="2012-09-05" version="1">MTADNPTKIKISTRSLRTQQSEEQNDYLDDDNPDIDQKDDQIISDFDDQQDIKRQEQSQTQEQIPQTKYSGSEFGDDLDDIPEPEQSDYNDEDSPPPKSAARNNNRRASTKKAPVEEDYHDEGTDYDSDEIYDTRRRPTRRGRPSTRRQVQRFVEFDDGDPDDDDAAFSLRGSRLRKRAENHSSERRSSRRSRPVVEYLPSKEVVQERHEKLANERALRAERRRNVMYTDDEDDDDSPERRNYSLRTRRERPNYVLPPPILDVRESPEKIGRLPSFTALQHPGIDLVPWNNRGSLDDSDTDDDLSPSKRPQPAISNLAGGGGGLLAPSGGMGIDSLGTAGPSNLGKVGDAAFADADPLGVNTKISFDSVGGLDEHVRQLKEMVSLPLLYPEVFQRFNVTPPRGVLFHGPPGTGKTLVARALAASCSNENQKISFFMRKGADCLSKWIGEAERQLRLLFEEAKAVQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDGRGQVIVIGATNRPDAVDPALRRPGRFDREFYFPLPNEKARSKIIEINTKEWDPPLEPHFVEKLANLTKGYGGADLRALCTEAALNAVQRRYPQIYKTNNRLLLDPKTINVQAKDFMRSIKKLIPSSARSSATSAAPLPQHLTPLLGEALIEARKVVDKVIPRNEEKSIIEEAEYEDEVGNDGGFSLEVMRQNMNNMRTFRPRMMVYGEEGMGQSFIGPALLHYLEGYNVQSLDLATLLGDSTRTIESACVQMILEAKRNKPSVIYIPSLHEWCNVVSEAARATVTALLNTISPSDPVLVLAMLNSRPDELPRDVKRWFGFGRDTKVALKDISEDQIREYCRELIDMIQLKPNMFPDTVQRKKRKLEELPIAPPVAPREPTERELNAQIENDARIREHLKWRLGAVLEQLKKKFRRFMKSFADEIAMVVPLPVNTNNNGTANALARVDVFAEPNQEQQNNEVQIVEKDTEGEQQNVDKENDDGSNIPNGVDESVSEEEKEKEDGEKDETDKQDDNEEPDSEKPEENGIQDDNIEEDKENSEEPAEKVENGDTEMAETTETVDEAPQVDQKESDDDEPIIEDRNDSDFEPEEDEEAVEPQPEVQTEAPPEVNAQENMEKTLDDELMALTEVQPGETQKERLMIYDIDLEKIHFNVYKDNYVNPAQFVDDVAKIVHNAELDKSDQDRLWKAEQLLTHARVLVDQAFDAHFRIECQRMADRESKRIAEYKEKRKKEREEKENKKKEEEALANKDKDDQQQSSNEQTENQDEHHDKDPSAESNEDAQSNEVGDQDHDNGTSLKRPREGEMEGLKEGPDSKKAKGDVEMHESSPGPENVESEKQPEQADQPGQSEQPEQPEQIEEPSTKSPTPEPEPEPEFVVDKQQLDALLNEAVTLLKDFNVDELEQTRAAISSVIWEHRYEWNRQSMIDVVRTTLHDCKYDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFN9</accession>
    <name>I4YFN9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957436.1">
        <property type="nucleotide sequence ID" value="XM_006957374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFN9"/>
    <dbReference type="FunCoup" id="I4YFN9">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFN9"/>
    <dbReference type="GeneID" id="18475362"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68203"/>
    <dbReference type="HOGENOM" id="CLU_1679321_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFN9"/>
    <dbReference type="OMA" id="THLPKTQ"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="166" mass="18968" checksum="BF1C3DC26815A6D3" modified="2012-09-05" version="1">MITTDRLSLIATSTLSKLLEREKILQLGLKYDDDELDSNLETLKEGYEVLADDDSDQALKFKHQYLNLLDLLGKDKPSPKPAKEMPLTHLPKSTSIQQTPSTSQQEHLFNYDDMMDQQDTHLDNLSQSIHNQHQLSNTMTTELGQHNELLNDLELENSSQIHQLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFS7</accession>
    <name>I4YFS7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADPH oxidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_31540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956872.1">
        <property type="nucleotide sequence ID" value="XM_006956810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFS7"/>
    <dbReference type="STRING" id="671144.I4YFS7"/>
    <dbReference type="GeneID" id="18471323"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31540"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="InParanoid" id="I4YFS7"/>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="274"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="573" mass="65179" checksum="9A420AE483E2AAA5" modified="2012-09-05" version="1">MSIEYPTTAHLRHRKANSLNKVQDGQTLSYKDLHNQQKHLTIINRLRIFLLNDGLSYLFIAVWVLISSLVFGLGFVHYDLNDEYVGARTIFGKSFVSAKSAALCLHINIAFILFPVCRTLVSFARSTPLGQVIPFDKNIDFHKIVGYAICFFTVIHVLSHQSNFARLAIHNGTGFKGFFFSNFASGPGATGWIMLLCLMTMLYFARQKKLRRANVGYERFWYSHHLFIPFFILWQSHGMFCMIQPDSPPYCNYNVVGVFWKYWIAGGVIYIGERLLREYRARKLTYISKVIQHPSKVIELQIRKEGIRTQAGQYIFLNCPAISLWQWHPFTLTSAPEEDYISVHIRIAGDFTKALAAKLGCDLDQEDKVIEGDDPNGVNAGVVNKVLPRVMIDGPFGSASEDVFNYEIAVLVGAGIGVTPFASILKDIWYRAHWPDPNKPTRLSKVYFIWVIRDFGSAEWFHSLLHAIEEQDLDNYIEIQTYLTAKIKVDDIQNILAHDIGSERDAISGLRAPTNFGRPNWDRIFQGITAKHPNTDAGVFFCGPQALGSALHKCCNKYSNPKGTRFFFGKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG96</accession>
    <name>I4YG96_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_43890</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957028.1">
        <property type="nucleotide sequence ID" value="XM_006956966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG96"/>
    <dbReference type="STRING" id="671144.I4YG96"/>
    <dbReference type="GeneID" id="18472309"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43890"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="InParanoid" id="I4YG96"/>
    <dbReference type="OMA" id="MAIIFRY"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="77"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="419"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM22988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="610" mass="65969" checksum="CE046111DF5F5985" modified="2012-09-05" version="1">MEFGKLNYSYYNHVSQYVCLNNWLPSNLIIDRHPIKKSSEQKVKLNKYSSVITEDISHLGAQAFLHAIGLKEEDLEKPQVGVLSVGFDSNPCNNLLNKFGEYVKQSLEKENLLGFAASSVGVSDAITQGTSGMNYSLPSRDLIADSFQMIVEAQQYDASVLIPGCDKNMPGALMAALRYNRPSIIVYGGTIKPGTHQIDCQPLNVKKGDQSNITDTFEAYGAYLNGKISEPELKIIKQNACPGSGSCGGLFTANTMSSIIEAMGMCLSYSACTPAETTEKVQECLKIGPVVRNLLEKDIKPRDIMTRSAFLNAITIVMILGGSTNSVLHLLAIARSGDVELTMQDFSDVAARTPFLANMKPSGKYMMQDLHEVGGLPAVLKYVYDSTDLLDGSCLTVTGQTLAENLANITVDYDKFHTVIHPLQAPIKDTGHIRILNGSLAPGNAVAKITGKEGLKFEGTAMCFEEEDDVLQAVADKRIVAGTAVILRYKGPKGAPGMPEMLTPTAALYGAGLSQSSCLITDGRFSGASHGFVIGHVVPEAFNGGPIALIKDGDRVIVDAIENTIDVDISQEELAKRQAEWKPRPLKHQRGVLYKYSKLVSDASHGAYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGH6</accession>
    <name>I4YGH6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957101.1">
        <property type="nucleotide sequence ID" value="XM_006957039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGH6"/>
    <dbReference type="FunCoup" id="I4YGH6">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGH6"/>
    <dbReference type="GeneID" id="18473539"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59757"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059252_6_1_1"/>
    <dbReference type="InParanoid" id="I4YGH6"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="165" mass="19106" checksum="65A1EF27E8719116" modified="2012-09-05" version="1">MAESEARVNLLTSDNEQFTVDKDIAERSVLIKNMLEDIGESDHPIPLPNVTSNVFKKVLEYCDHHRKDPLPSSDESADDSRKRTTDINEWDQKFIQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKTPEEIRKLFNIQNDFTPEEEAQIRKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGZ4</accession>
    <name>I4YGZ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_35662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956627.1">
        <property type="nucleotide sequence ID" value="XM_006956565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGZ4"/>
    <dbReference type="FunCoup" id="I4YGZ4">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGZ4"/>
    <dbReference type="GeneID" id="18471920"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35662"/>
    <dbReference type="eggNOG" id="KOG3219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1289836_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGZ4"/>
    <dbReference type="OMA" id="PATNTHD"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="201" mass="23069" checksum="ED5CBADE5E456BF3" modified="2012-09-05" version="1">MQQQKRPRSSTPGELSFPGTPQTVASPESKKGRGRPRKTDKDKKGSLSPTLPQNELEPAQPQQQQKKPEEDDDDEIEDDWMEDDDFERERVQSKKAKEDLGVLLQHFSSEQLQRYEVYRRAALNKNTIRKLCNQTLNQSVSQNVSIIVSGFSKVFVGEIVEKAREVQEAWGQSGPLSADQIREAHRLYQKDKGAYRKPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH20</accession>
    <name>I4YH20_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956652.1">
        <property type="nucleotide sequence ID" value="XM_006956590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH20"/>
    <dbReference type="STRING" id="671144.I4YH20"/>
    <dbReference type="GeneID" id="18473405"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59524"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_2_0_1"/>
    <dbReference type="InParanoid" id="I4YH20"/>
    <dbReference type="OMA" id="YYALEYP"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8669" checksum="38D028C9F83066E9" modified="2012-09-05" version="1">MSRILQPFRFLHRMAHEQPVYLWSFGIGLTGPLLVIAVPEIRSKFFGWKPTERLPTTYPVPQRERRAVEGFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH93</accession>
    <name>I4YH93_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_53616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956719.1">
        <property type="nucleotide sequence ID" value="XM_006956657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH93"/>
    <dbReference type="GeneID" id="18472623"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53616"/>
    <dbReference type="HOGENOM" id="CLU_2225260_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH93"/>
    <dbReference type="OrthoDB" id="10490476at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="12071" checksum="8ED53DEA202B892E" modified="2012-09-05" version="1">MRILAAPVRGLQLQQRVQFSQNLPRFGRTSEQELKERNEQPESPPPTAHTGIYTRTSEKIEERTETEEADSVEGPLKDRTKGRSGSETISEENVRSDHADDPLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC1</accession>
    <name>I4YHC1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956744.1">
        <property type="nucleotide sequence ID" value="XM_006956682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC1"/>
    <dbReference type="STRING" id="671144.I4YHC1"/>
    <dbReference type="GeneID" id="18473433"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59577"/>
    <dbReference type="eggNOG" id="ENOG502QRIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387395_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHC1"/>
    <dbReference type="OMA" id="IDTIMIM"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="702" mass="78611" checksum="94202F33328D2FF3" modified="2012-09-05" version="1">MAIIVRKVASAWSRSNFPPPEIDRMFRIIESVYRINRSFLNNLLSTNNNYKLIGDSLLNFIKDFQSSYDKYVQLYTSSPPFSKHKNIQENDQLHQILASMDRDIDELFELPAKRLKYYLNLYKKLLTSTNPSKPDYNLLKDSVETLQRLVDLIDNSTINKLTSSSTSLSHQPTVRFNPEDPLKLRAKASNDIQSDDSSISTISQDDQDDIDDETDNNQNNSDDTASIDSHNSTMNKRESPPIPEAQLKAVDLSERLDTSRTLDIFTMQQKKCKLQIQPPQLPFKRELRRSADVVLSFTPSAAPQSTQEIVMRRAHIFLLSDLFLVAERMTANEKEAGVALPGTDMWLSFPPLSGKFLKATQNKQENAFDLGIMNKETLTIKVESIEARDSWIQDISNCTQFAFNGTTNKPPPSDQLQNLNLNAPPAQISSSQTSSPQFPNPPPRDHLPPMENVPTLGSQFERPPPPHVLQNNQLTANNLSNIPGYGPQPAQIRPIRPGMIPPPPPPFDTLPPRLQQNDNMNRMPSLDTINTNSTNSNSNSNSINGGLSKYAMPSNLMGQFKTASPNTKSQDEDTPPPSPTEIKPTEPEKIRMSAQMRCKVFIKHGHQAWKSLGSGGLKLFTQSPQNKKQLVVESDKAKSLLISNYVLLDAVERVGKTGLAVEMSDNGQRTGVIYLLQLKSDQSAKGLFDELVKGSSRDANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC6</accession>
    <name>I4YHC6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_31470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956749.1">
        <property type="nucleotide sequence ID" value="XM_006956687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC6"/>
    <dbReference type="STRING" id="671144.I4YHC6"/>
    <dbReference type="GeneID" id="18471309"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31470"/>
    <dbReference type="eggNOG" id="ENOG502S0JD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="I4YHC6"/>
    <dbReference type="OMA" id="IDCRDIG"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="30160" checksum="D7800D8CC88E1809" modified="2012-09-05" version="1">MFLISGATGQQGGATIRNLKGVPTRAFIRNTHSEAAKNLSADGVELASGDLTNSESIYAAMEDVDGAFLVTTMVPNGPQDEIVQGKAFIEAAKRRNLKHIVYTSVEGAERQSGVPHFDSKYEVEKMIYESGIPYTIIRPVAFMDNFPKTSGVASFFAIGVFNAAIRNRTVQLIATEDIGIVAATALKKPEQYIGRKIPLAGDELTTAQIQDAYKVAHGSSAWKVYLPTFILSVLPHDFKKMFYWFRDHGYEANIAKNREEFPGLLTFSEWLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHF5</accession>
    <name>I4YHF5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956777.1">
        <property type="nucleotide sequence ID" value="XM_006956715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHF5"/>
    <dbReference type="GeneID" id="18474788"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62762"/>
    <dbReference type="HOGENOM" id="CLU_1416174_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHF5"/>
    <dbReference type="OMA" id="NPMENVQ"/>
    <dbReference type="OrthoDB" id="3349723at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="192" mass="21223" checksum="39ED65AEFE0377B6" modified="2012-09-05" version="1">MTDSAPTSPSKQIPNPMDSVQTHLDKEEVHSVIGTPAQPNDNKVLIGWKNSPDGNKALEHYLNKLAKPQDHVILLVVLPTTLFKSSGFGTDDKKMERKALRDLREHAQQLASEKIKLIEAKGATASLEIVHGERRYVIEWLALRRKVDLIILGRKKAHAPAKGLSKVFLGHPIGSTVQHVLHKVSVPVLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHN1</accession>
    <name>I4YHN1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956152.1">
        <property type="nucleotide sequence ID" value="XM_006956090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHN1"/>
    <dbReference type="STRING" id="671144.I4YHN1"/>
    <dbReference type="GeneID" id="18473228"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59212"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313790_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHN1"/>
    <dbReference type="OMA" id="MEWINIQ"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="148"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="628"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="910" mass="104785" checksum="D53264BEF8164503" modified="2012-09-05" version="1">MEETYEIKISLDGNYCVTRDGDTARKLKKMLDLKYNVGAVVDGEIKSSSLTIQIKSENEYVVKPKDSSKMDLRLQLPNSFSQLKNYLEELLPESESPSGNYFGGSLPLNDDKLTAFDGEITNISNRKELFELFDEYQINKDKEICLSNDKTVLAASIHRWISQLSSEFLFDDLELFYNTYRLYLNQMELAEILFKRFEWTLEDSDKFDESQLELVRVRTFVMIRGWLSNYFGYDFVPNLELRLRLSEWINHQREQNNEKSRKMIEKMINVARERQNVYENYKKYSLDESISSFDSNLSQTDGKLSLDFDPGPPTTLPSSNSSKFTMNTNPTSTANVGQNDSITGTFFKTFNKFGKFGKRIISNRPQKTIEEDDTMKNEYTISLTFEEFCQLQEIPIENNNDNSSNEIKNKENDSIMTKIMQLDDLDYSDDSSSSDTDEEESFAKAKKLPHVRQDRDSGKSSRSTVKSMNSTESQIEANWQNNFTIEGLESDEEEDGDVDAALRALEGQIDKVKQEEKLRKVETMMERSKKKRLSQSGNSNTSSPAGSPLIRTKSVFQSSTNGVGNGNSNVHTIKEVITHKPRSHSVAITTPSRATQHTNRKRGLSQGSSVIIDKAKKNGTRSWILQYRTEMIAKQFTLIERDLFNEIKFEHIENLNNWKEDYYKFDTIISWISFMKEHARKKVIGDANGCSVRVIIARFNMTVRWVASEILITASTEDRTSVIGKFIRLAFKCQQQNNFMTLMAILRGLEHPLVKRMADAWPHVSKQSMRMLTTLKKFCSNADNFSMLRHTSLNQLNKNLSETTSERRMTRDRSSSSVTGSGVGDINGCIPFIGIFLNDLLQANNSPNYLERDSNEVMVNIQKLRLIHSTRKTIELFQTYSTNQFDHRSYLDGDLYRKCLKLRLDCRVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHN8</accession>
    <name>I4YHN8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_14687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956137.1">
        <property type="nucleotide sequence ID" value="XM_006956075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHN8"/>
    <dbReference type="FunCoup" id="I4YHN8">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHN8"/>
    <dbReference type="GeneID" id="18470639"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_14687"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027974_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHN8"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="248" mass="28595" checksum="D7C89D3ACD45859C" modified="2012-09-05" version="1">MQTQIREVWADNLDAELDILRELVDRYPYVSMDTEFPGVVARPIGNFKNSSDYHYQTLRCNVDLLKIIQLGITIADADGNMPEYPTWQFNFKFSLNDDMYAPDSIDLLTKSGINFKRLEANGIDIEEFGEKLVTSGFVLFDHVHWISFHSGYDFGYLLKVLTSLPLPSNENDFFDLLRIWFPCIFDIKYVMKINRLLKGGLQDIADELQVMRIGPQHQAGSDSLVTSASFFSMRTKFFDGTSERDRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS3</accession>
    <name>I4YHS3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_27026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956192.1">
        <property type="nucleotide sequence ID" value="XM_006956130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS3"/>
    <dbReference type="GeneID" id="18470973"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27026"/>
    <dbReference type="eggNOG" id="ENOG502SW0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1009025_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHS3"/>
    <dbReference type="OMA" id="VEYTDIM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="276" mass="31705" checksum="AB612EA48E24987D" modified="2012-09-05" version="1">MPHIWLQFASISLEEGSYDLGLNNFEFIRCPGYVPSEHYIQQFVYLALARRPTQEETERLVNRKLRGRSSKKKSANEFEKRDHSSLTDEKMAKSALKLLHRLLEMQADTKFIEDEQKDHLEFIVNALPSYRQHRQPRDGQVGLTTKLAKGAAEIDDCQSIWQTLRLQGEREGDDVVVDENAWGFFDFLVTLWETQDRLNGKPYHLLDNLRDCKHDISEAVDAIIAGFETPTELSPLSCSTSVGFKVRQDSNSLFDSKIASESLQRRSISSRLLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHS4</accession>
    <name>I4YHS4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase CHFR cysteine rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956193.1">
        <property type="nucleotide sequence ID" value="XM_006956131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHS4"/>
    <dbReference type="GeneID" id="18473244"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59244"/>
    <dbReference type="HOGENOM" id="CLU_1195666_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHS4"/>
    <dbReference type="OMA" id="IDYACIC"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24887" checksum="9847717600BABA55" modified="2012-09-05" version="1">MEVPELVSDTSSVYQSSPEIQPFDKSHDMGTLANDMLELDYACISCNPNNTTGFVCPTPFSIITKKTKKNVENWHTNLIRGDKFREIGIRNHEECTGCHRFIPSKIPNLNNCSCCGSHSCDSINPNGCSRNFKITPLESPKLPPNSLNWILSNHNAATLLKKYETVDSLLGAVVQVLPKSGENARILSNGMVKKLDDNICSNCVWKDVVVDGLHLLWKHTNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHU9</accession>
    <name>I4YHU9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_31055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956218.1">
        <property type="nucleotide sequence ID" value="XM_006956156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHU9"/>
    <dbReference type="FunCoup" id="I4YHU9">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHU9"/>
    <dbReference type="GeneID" id="18471240"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31055"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_1_0_1"/>
    <dbReference type="InParanoid" id="I4YHU9"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="159" mass="17337" checksum="224E684A9E8ACF36" modified="2012-09-05" version="1">MSDNEEQVTFESADAGAAMTYPAQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVNLVALDIFTGKKYEDVSPSTHNMDVPNVRRSEYQLVNIDDGFLNLLKKDGDSKDDVKVPEGELGEKIQADFDDGKDLMISILEAMGEETCVSYKEAPQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI13</accession>
    <name>I4YI13_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956276.1">
        <property type="nucleotide sequence ID" value="XM_006956214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI13"/>
    <dbReference type="STRING" id="671144.I4YI13"/>
    <dbReference type="GeneID" id="18473269"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59286"/>
    <dbReference type="eggNOG" id="KOG1901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1062473_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI13"/>
    <dbReference type="OMA" id="DWETSAS"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="74"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="262" mass="30003" checksum="32ED6176E8C5B7F5" modified="2012-09-05" version="1">MNPPTSHWRFDPITGRALTPPQKTLQTRLQQSNSKSPSSQSPSMQEMLSSTDISTMVQQNGYNPSQFDLNPSHARYFVIKSYTEDDVHKSLKYNIWASTELGNQRLDRAFNESANRGPIYLFFSVNASGHFCGMAQMLTHVDYTTSSSVWAQDGKWKGVFKVRWIFVKDIPNSTLRHIKLLNTNEKKPVTNSRDTTELLDDAGKEMLNIFFQFNSRTSLLQDFQFYEIQSIQKNVAQSNNKISRQSPNLHANPFANVSHQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI25</accession>
    <name>I4YI25_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_15012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956145.1">
        <property type="nucleotide sequence ID" value="XM_006956083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI25"/>
    <dbReference type="FunCoup" id="I4YI25">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI25"/>
    <dbReference type="GeneID" id="18470647"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15012"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_3_1_1"/>
    <dbReference type="InParanoid" id="I4YI25"/>
    <dbReference type="OMA" id="EPEENEF"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="83"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM23617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="465" mass="51994" checksum="240CBF69176864A5" modified="2012-09-05" version="1">MVLPTEEEKEREATEGQDAQVVYGRIRDIVRILGDFRRFKAANRSRADYTQQLIADISSYYGYTPFLAEKLFSMFSPDEAVAFFDANETPRPVTIRANTLKTRRRDLAQALINRGVSLEPIGKWTKVGLQIFDSNVPVGATPEYLAGHYMLQSPSSFLPVMALDPQPNERVLDMASAPGGKTSYMSALMQNTGVVFANDANAARTKSLSANVHRLGCKNVVVCTHDGRQFPKVIGGFDRVLLDAPCSGTGVVSKDQSVKVNKTERDFALLSHLQKQLILCAIDSINTKSATGGFVVYSTCSVTVDEDEGVVDYALKKRPNVKLVDTGLEFGVEGFTNIGGKQFHKDMHLTRRFYPHVHNMEGFFVSKLQVLPRSVLKNKLQQAEEKEENDERLEEDDNEAGADVTFNDDEDKALMESEYFTLTRNCLTKTQKTNAANKKLEVSSHSNLKPSNLFFRLLLYIRDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI71</accession>
    <name>I4YI71_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956330.1">
        <property type="nucleotide sequence ID" value="XM_006956268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI71"/>
    <dbReference type="FunCoup" id="I4YI71">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI71"/>
    <dbReference type="GeneID" id="18473290"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59316"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1409806_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI71"/>
    <dbReference type="OMA" id="CDENSHN"/>
    <dbReference type="OrthoDB" id="3233701at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="21824" checksum="8EA81AFB1DBC42F6" modified="2012-09-05" version="1">MKSLKKAFGGDKEVSSVTRLIEIYSSNEYEENSIEGVFDIVESIHFMKRNGAVEASRALRKQLKHGSTHQNIRALTIFHGCVSNGINNSNFPDSELEARFRLIASDPVYDSKVKKKLRSVLRSICEENNQNSRYKQLYEDCGSVKPARPARRTPSTLSKLSTSSIPKLNQQKAHKVADSPIEIEDPFADPPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIC9</accession>
    <name>I4YIC9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_42923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956386.1">
        <property type="nucleotide sequence ID" value="XM_006956324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIC9"/>
    <dbReference type="FunCoup" id="I4YIC9">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIC9"/>
    <dbReference type="GeneID" id="18472270"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_42923"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIC9"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="357" mass="40669" checksum="44082417B8234A88" modified="2012-09-05" version="1">MGLLGSEMLFFNVHNGYLEGILRGYKAALLTHSNYTNLQQCDTLEDFRMQLSATDYGNFLANESLPLSTSKIAEKSTNTLVDEFKYISTNSTEPLSTFLDYITYAYMIDNVILLITGTLHGRDTHELLERCHPLGKFDAMSALCVATNVEELYQSVLVETPLAPYFRNCLTASDLDDLNIEIIRNAVYKAYLEDYHAFAQTLEEPTASIMTKLLAFEADRRAINITLNSFGTELTKEMRSKLYPEIGRLYPAGTNVLARADDFDQVRAACESIPEYHQMFDGISSNSADNDDNNSLEDRFFAHEVLLNKETFLQQFNYAPFYSYFKLKEQEVRNIVWLAECTAQSAPQDRRAVPYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIG6</accession>
    <name>I4YIG6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Calreticulin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_8174</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956133.1">
        <property type="nucleotide sequence ID" value="XM_006956071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIG6"/>
    <dbReference type="FunCoup" id="I4YIG6">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIG6"/>
    <dbReference type="GeneID" id="18475837"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_8174"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="InParanoid" id="I4YIG6"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000048">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 18" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM23758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="481" mass="53103" checksum="C19652C3F9B5B98B" modified="2012-09-05" version="1" fragment="single">ASVAAIAQAATYTPTNIKAPFIEQFDQNWESRWKQPASSRFVVKEPEVYPGIDDDKGLIAIQKAAKYAISSTFDEIVNPAGEKPLVVQYEVKLQEGLECGGAYIKLLSEGFGEDSTMTSDTPYTIMFGPDKCGMTNKVHFILRHKNPLTGEVEEKHLDNPPSIKQSKTTALYTLIVNPDNTYEILINNESVKSGSLFKDFTPPVNPLREIDDPHDTKPADWVDEAVIPDPNATKPDDWDENAPKQIRDPNATKPAGWNEDVEAFIPDPSTEKPAEWDDDEDGEFVAPLVPNPDCDLTVGCGKWEAPLIANPNYRGKWHPDMIVNPDFKGPWLPRKIPNPTYFEDKEPSAITPISGVGFEIWTMSRGILFDNIYVGYSKDDAKAFADETYAIKKPIEEKREREALEATVHDPSESEGFEALAFIRKNLIDFVAKFNADPVLAFKERWDVAGVLGAAIAAFLGLLGTLISIIGGTTAATSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIQ5</accession>
    <name>I4YIQ5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_66750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955693.1">
        <property type="nucleotide sequence ID" value="XM_006955631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIQ5"/>
    <dbReference type="FunCoup" id="I4YIQ5">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIQ5"/>
    <dbReference type="GeneID" id="18475141"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66750"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383658_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIQ5"/>
    <dbReference type="OMA" id="TPIVECK"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="99"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="721" mass="80456" checksum="80C67B21C6499B72" modified="2012-09-05" version="1">MAVNEEDVKNKLNILTVENLKSIIRVLNSQLKLKLRLSGNKADFVHRILDTLDHYKEHNKANYDVTKDIVMQVYNTGTYSRPASGSGPRLPPTLNLPTKHPAYEQPAAPKPLIWKSNPFQSIIRQVSDVATLHEARDRSLRSVFLEFKIPTDYSQQLNQSRIGPSDPIRYQLRIYSASSDFYKPHLLDQQLPIDFPVLCDLKVNGKQIKANTRGVRNQPGTASPPNADVEKNLILSPNASNTLEVIYRDTHKKHYIVINLVEQYSCDQLANIVRQQPEIPSTSVVERYKSMQDNDDVVAGASTVSLKCPIGFFRMQTPIRSIHSQSLQCFDAMSFFSINEQLPTFTDPSSKKPIKFKDLAVDGFTHQILQAIPDDYGSVVVEPDAEWHTEDGEYGSEAWMEAKKAGKIPEFNKAEKQPSAKPVKNEKQEKSAEVLDLSSDDEDADGSSYAKAPPRPPAKKQQQIIDLTLSSDEEDEVNNDSANDDANIVSTGNDAGPVNLNTVGSSNDDVDQRLPPLHIPQEAPAQVSLKRNRDSDDQASNILDKRRNIESNVESNIESNSVQNSTPVSASNSVLSGARTPNGNPPGPFILRESGPLPASHSPQTPFSSAHPTPQPQQEQIPRNDQQNIHQRERSPWVPQPLTLPQISNNFTVKPDPFVPPRQEHRVIQPNQEVVHQPSFGELQGIPPAPPTLPPPTFARLPHPIYRPPSQRDNSSRYHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB0</accession>
    <name>I4YJB0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">allantoinase</fullName>
            <ecNumber evidence="5">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_66918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="5"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955882.1">
        <property type="nucleotide sequence ID" value="XM_006955820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB0"/>
    <dbReference type="STRING" id="671144.I4YJB0"/>
    <dbReference type="GeneID" id="18475178"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66918"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="InParanoid" id="I4YJB0"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="84"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="496" mass="54683" checksum="3E21572BF6AE96A0" modified="2012-09-05" version="1" fragment="single">MQERNLYTFAALAAVLTTLLLKYLLGSDVFTITADKALLSTSYEFQPATIQINKKTGKILDVFGGIRKDKKVGKSIHYGSSQLLLPGLVDTHVHINDPGRSEWETFDSATKAALAGGVTTLVDMPLNSIPPTTSVKGLDEKKSAALGNIHTDLAFWAGSVPGNTKELSKLLKQDGVKGFKSFMINSGVDEFKSVSPKDIEKSFKELSKSANKGHNVTMLFHAESNSKKIDKQIKKDLAGKDSRQYETYLLTHPVAYELDAIKTLIKLMKKYPLINVHIVHLSTAEALPLIRQARADGLRLTVETCYHYLYFNSEDIPDGSVKHKCAPPIRDSENNKLLWKAIKDGDIDLITSDHSPADALTKNLEEGDFLNGWGGIASLGLGLPALHKKISEDTCENNLSLGELVEFLSHKPATLAGLGDRKGLIQKGYDADFAIFEPNSTHVLQEQDLLYKNQISPYVGEEFKGRLSRTYLRGVKAYDRYQGGVLEPSKHRGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB5</accession>
    <name>I4YJB5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_8551</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955639.1">
        <property type="nucleotide sequence ID" value="XM_006955577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB5"/>
    <dbReference type="FunCoup" id="I4YJB5">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJB5"/>
    <dbReference type="GeneID" id="18475842"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_8551"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010104_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJB5"/>
    <dbReference type="OMA" id="QVYRDWW"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="374" mass="42652" checksum="21468F0E9E88D6C9" modified="2012-09-05" version="1" fragment="single">EVINATNEENKDEPYDLYFDLLDKLQSDDVESNSKLVIQQIHKRLSHRNLKTQLLSLKLVDFLLKNTNPPISIQKEVASLSFTQSLQRLILDRNSDQELKYLTTKLVYTWADDFDNSNDSTTLGLMREVADNLANQNIYPQQENSRPRPPSPDYQKLKQEEDELQKVLEMSKMDIGGRFNQVATSPSLPSTSTQSHTFNTQQQPTSASPPPPVTKTSSNEAPQRVKALYDFEPQEANELGFLKGDVITVLESIHKDWWRGELSGEIGIFPVNYIQVLPNLTPSQISSEAQVEAQLFDSAGDIDRLLRLLQDIDPASGDNIADNDEIQDLYDKTLRLRPKIVKLIEKYSRKKDELVAINNRFNQARDLFAGMMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJG5</accession>
    <name>I4YJG5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_66965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955933.1">
        <property type="nucleotide sequence ID" value="XM_006955871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJG5"/>
    <dbReference type="STRING" id="671144.I4YJG5"/>
    <dbReference type="GeneID" id="18475189"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66965"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_2_1"/>
    <dbReference type="InParanoid" id="I4YJG5"/>
    <dbReference type="OMA" id="FLIETSM"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM24107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="26900" checksum="1CA75A8C8F1DB60E" modified="2012-09-05" version="1">MATKAGEEATKNINADKAAYVQTDITSEESVKNAMKVASNAFEKRLSGLVHCAGIAMSQPWTNRLEDTIGRSRRLLEINYMGTCITNALFADAVNERFEPEKMASGELFTTKEERGAIINFSSIAGHQPYTRILAYTGGKAAVSAFSRALADFLGPSGENTVLSCPKRHNSANIGARLSYFLAELTKTSSFPARPITPDEIAGAVNYLITNGMMNDHDLRIDGGWRFIFDRIVDREDPRLSAPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW9</accession>
    <name>I4YJW9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956077.1">
        <property type="nucleotide sequence ID" value="XM_006956015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW9"/>
    <dbReference type="GeneID" id="18471218"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30954"/>
    <dbReference type="HOGENOM" id="CLU_2387862_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJW9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="94" mass="10062" checksum="86B931052F68E0C2" modified="2012-09-05" version="1">MPRRPPPSPLKLLPNNVPLPGRDCPKQAHILPRLPPNALLRQSPIDLTASNVMGVDRMVVGSRNRTNSLSSLSRSSIDSAESASSFGSSSGWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y505</accession>
    <name>I4Y505_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668272">
        <property type="protein sequence ID" value="EIM19047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960907.1">
        <property type="nucleotide sequence ID" value="XM_006960845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y505"/>
    <dbReference type="STRING" id="671144.I4Y505"/>
    <dbReference type="GeneID" id="18473090"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58957"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016187_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y505"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF11">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN DDB_G0284757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="503"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="631" mass="71436" checksum="841AFDB788235180" modified="2012-09-05" version="1">MVETKMYSKIAHVIRSIGVKPPLFKANNISSLKSRYHSAKKTFDQISNKPDKAIQGFRVEATIRATNLIWALEIALIYKLLDSGTYDQRFELIELPRSVYIANAQKLINKVQDYNLLRGSNNTKVSNERSKVEADVWQSVGWNSSRRKLTRHNDVNAWWNDQITSHVFEKNIRFVSHVFFSDTYNCRTFFRLVKSKLKCPKCGALDSYHSIGRADSFSIRCGKRECLNQMGKKKCTALWDELLKGEDSEYFQDAIDTTKEANCSPRLTPSIQNNSTDSNNSPCLSESPESPWETFIPQRYFHESSVSSICPSLYDTPEPRKRFIAEISSGSSSHSTSPFYDSSSASDGSSHSTYSSLYDSPEPPQKKVIVELSSDNSSGLASPPLFQPPVPHRKGSVIVISSESSEGIPEPHPLCMFQDDGFSRWPVPEDNGLYSAESRQCVESEVRAATPTSLPVQATSTEQIHHEMADRPKYTLHTLWKNILDSNFPESVNIYQITDHYIRTEGYIVGDGNCMFRAISFALYGDQRKHGDVRKLVVNYMAENIDERVGQEKVKLLCDLNWRDYLEEMQKEGTWGDEYVLINAALACRTNIAVLSTGGTRKYIKTFTFSGEQVIAICHDGSHYEVLKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C1</accession>
    <name>I4Y5C1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_34232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960785.1">
        <property type="nucleotide sequence ID" value="XM_006960723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5C1"/>
    <dbReference type="FunCoup" id="I4Y5C1">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5C1"/>
    <dbReference type="GeneID" id="18471838"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34232"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031077_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5C1"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="298" mass="34761" checksum="4BC630164377A380" modified="2012-09-05" version="1">MSFLGFGPSVELSIALNEEQDRRTAEVKDQKDRKTNCPIYYDGENVNGQVSVRVKDGKKITHEGIKVEFIGTIELFNDKSNHHDFLTLSQELAGAGDLRSSQTFDFNFKNVEKAYESYHGINVNLRYLIRVTLSRRMNDVVREKELYVHSHRMPPEINDVIKMEVGIEDCLHIEFEYSKSKYHLKDVIVGKIFFLLVRIKIKHMELSIIKRESTGSGHNQYNESDTITKYEIMDGAPVRGETIPIRLFLGGFDLTPTFRDVNKKFSVRYYLNLVLIDEENRRYFKQQEITVYRDEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5J9</accession>
    <name>I4Y5J9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960738.1">
        <property type="nucleotide sequence ID" value="XM_006960676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5J9"/>
    <dbReference type="FunCoup" id="I4Y5J9">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5J9"/>
    <dbReference type="GeneID" id="18473079"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58862"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032167_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5J9"/>
    <dbReference type="OMA" id="CHARDTS"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="439" mass="49888" checksum="800588EDBCABC1CF" modified="2012-09-05" version="1">MPQEYPIKRNDLADQRPSTSLAPHIKKSSRNTNNSTFLTAQTKVGKYNHEWCDACGGEGRVIMCDGCDNSFHASCLDPPMDLGELSEDVEWYCRVCQFTNNKPRPPTNWSDQLMYHRDISNPKSFSLPVSIRKYFFGVETAYDGSYSTSSDTKTVKTDRFGAALTERDAYPTKDKHGNAVKCYKCKGSSAPSLSPSNDNDRNRAITASSSTSTTHTEWRKMISCDYCNCYWHLDCLTPPITQIPSMSRMWMCPLHAEHAKSLHMKMKNRIPKENIKEVNNKLSRSDSVTIIGNSSKRSKKSNDRLDKEKFHIPEQSIQLDFWNKVKKGKGSRLRYSKSFLEDVPTVNAVEGLMALSKPSPSETRKMVRRVMQGRSATIKEENDKGEESDSSSLSSAPVSDDEESNKKHLIDESRLRKIKTIERLLHIKGEKETIEFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M4</accession>
    <name>I4Y5M4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_12424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960647.1">
        <property type="nucleotide sequence ID" value="XM_006960585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5M4"/>
    <dbReference type="FunCoup" id="I4Y5M4">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5M4"/>
    <dbReference type="GeneID" id="18470603"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_12424"/>
    <dbReference type="eggNOG" id="KOG3429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y5M4"/>
    <dbReference type="OMA" id="GGQNVNC"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="149" mass="17045" checksum="26900BB53DBEC26F" modified="2012-09-05" version="1" fragment="single">EQTQFIAREWLKKLQNFKIPEESVDFTFSRSSGKGGQNVNKTSSKATARMQVKQNWLPKYVHNALREDAHYVKSSDSVVVSDSSTRSAAQNSRIASHRLESIITIASEKGVINETSPGKAQRVDNFKRKEKANMEKMKKYQKEKKALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5N7</accession>
    <name>I4Y5N7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_70724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960673.1">
        <property type="nucleotide sequence ID" value="XM_006960611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5N7"/>
    <dbReference type="STRING" id="671144.I4Y5N7"/>
    <dbReference type="GeneID" id="18475782"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70724"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010228_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y5N7"/>
    <dbReference type="OMA" id="RNADLIH"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="123"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="532" mass="61302" checksum="B852C18401F9D884" modified="2012-09-05" version="1">MALIQPKKEDRNDWQLVLSNTPHQVVLYHTPTKSLKVSPISPTNTATEAGIICPTCLRPLDEEEGGNTTDYFRLLESLTIENNKAQPFHAKRNSIAGTTPAQHYHSKEDDITSRIDGYYEKFFIELRQIGRGAFASVHLCQHSLNGNLLGLYAVKKIAVGLSSDYLKKALQEVKLLESLRHSHIVDYHHSWVELATLTTFGPRVPTLYLLMSFANGGSLAELIRARQGHHVTEDMRSSDNMTKEELIASHKRRLGKRIERTYEGPSKRINYFHNDELLLLFRNICDGLEFLHSKGIMHLDLKPANVLLNWDETNDTIPRAMLSDFGSSFAGVGNPERTGQTGTMEYTSPEALYKDERGRLLKERSFKSDMWSLGMILYEMIFFSLPWQDYDNNYEELNEEILNYAGFDEQALEMAKKRRPDVPIRILELLRKLLDRDVNNRPLASEVLEEVMSTELIVEKKDKIPLIRKQKMMKIALFGITLLKVMLLHDIKSIWLRLYLGLTIVIDFEYRKIFYSAVLTVILFILYYNDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Y8</accession>
    <name>I4Y5Y8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_34056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960530.1">
        <property type="nucleotide sequence ID" value="XM_006960468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Y8"/>
    <dbReference type="FunCoup" id="I4Y5Y8">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5Y8"/>
    <dbReference type="GeneID" id="18471804"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34056"/>
    <dbReference type="eggNOG" id="KOG2062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002323_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Y8"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="7">
        <location>
            <begin position="743"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="983" mass="107528" checksum="08E204B4C3283162" modified="2012-09-05" version="1" fragment="single">MSSLTTAAGILSLLDEDDITIKTHALTSLIGVVDQFWAEISDYVGKIESLSEDEKFSPDSRKLAALIASRVYYHLGAIDDSLSLALGAGSAFDVSQSNEFVETLISKSIDTYVHLRQNNEKVDSRLENIVNRMFDKCISDKEYKQAAGIALDSLRYDIIEKVFNLSKDVNILRYVMEATSDVIVSLEQRQVIFKLLVKLFSSNILSSPDYFSITQCHLLLNDGKLAGELLDNLIKSNKKENTLIAYQIAFDLVDTASQDFLSHVTNVVKEGEGETYDKLKEILSGTLSIRLNLEFLHRNNKADPLVLKNTKESLDGKFSLYHNAVSFANAFMHAGTTNDTWLRDNLEWLGKANNWSKFTATAALGVIHKGNLNQSIQLLEPYLPGATSHASEYSEGGSLYALGLIHANNGGHSLNFLLDHLKRVGATEVVQHGAALGLGIAGIATKNEELYTELRNVLFSDSAIAGEAAGYAMGLIMLGTGNESAYEEMLQYAHETQHEKIIRGLAIGIAFLMYGRESEADKVIENLLNDKDWILRYGGVYTIGLAYAGTGNNKAIQNLLHVAVSDVNDDVRRVAVIALGFILYRNPSQVPRLVQLLSESYNPHVRCGAAMALGIACAGTALDDAIELLEPLSKDPVDFVRQYAYISLALVLIQSNEQNAPKSKSIREHFAKVVSDRHDESMAKFGAAIAQGLIDAGGRNSTISMQSKNGSTNISSLVGMTLFTQFWFWFPLVHCISLSFTPTSLIGLDAELKIPEMEFVSNVKPSQFAYVKALKPPTKETAERVATAVLSTTARAQARHNKAKKEKEEAEGGGDVEMEEKEEKEEITNEEESKKIEVKEPEPEFETKSNLSRVTPNQVPFIVFSSDGRYTPVRSVSQVPATTRVNNGSGSSTPVSINRRTRRPTISSIYSTTPASAGGAGILILNDHKEGEEVKYITLEAGGGQGGVGSTTAATTKDQGGVDDGIEIDNPPEAFEFNFDQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6E6</accession>
    <name>I4Y6E6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ptc1p</name>
        <name evidence="7" type="ORF">WALSEDRAFT_66294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960461.1">
        <property type="nucleotide sequence ID" value="XM_006960399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6E6"/>
    <dbReference type="FunCoup" id="I4Y6E6">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6E6"/>
    <dbReference type="GeneID" id="18475105"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66294"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y6E6"/>
    <dbReference type="OMA" id="IDDQEAC"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="257" mass="28438" checksum="660546FAF56DACD1" modified="2012-09-05" version="1">MQIGISEDQNRKYRKTMEDKVTVIEDFNNINDQLYVGLFDGHAGKSLSDYCGANLHERILSNLEKEKEISDNLNASFLSIDNEQSLSSGCTAVVSLILHQGMNKEINQDKREAEGARTLYTANVGDARAVLCRAGQAIRLTYDHKGSDDNEQKRIMDAGGYILNGRVNGVLAVTRALGDSPMKQYVVGSPYTTEIDITDDDEWLVIACDGLWDVATDSEVCELIKECKSGEEASKLLLEYALNNLSTDNLSIVVIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6G1</accession>
    <name>I4Y6G1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_33935</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960351.1">
        <property type="nucleotide sequence ID" value="XM_006960289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6G1"/>
    <dbReference type="FunCoup" id="I4Y6G1">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6G1"/>
    <dbReference type="GeneID" id="18471779"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33935"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="I4Y6G1"/>
    <dbReference type="OMA" id="ESRFPEW"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:homologous chromosome segregation"/>
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        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Aur-like"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="61"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="26"/>
            <end position="39"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="11 13">
        <location>
            <position position="91"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="140"/>
            <end position="142"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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            <position position="203"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="187"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="PROSITE" id="PS50011"/>
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            <dbReference type="EMBL" id="EIM19553.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="325" mass="36962" checksum="C2C4C31C9E67CBEB" modified="2012-09-05" version="1">MANSLNTQSTTHKANNDSLIGTYDGGLERDEEDRKSDLAGGDKGRILDLQLRGQAWNLNMFDVGRPLGKGKFGRVYMARTRTQPPFVVALKCLYKTELVEARVEKQLRREIEIQANLRHPNILRLYGFFYDGKRIFLMIEFAGKGELYKQLNKLGRFSDKRSSRYIAQMADALLYLHSKHVIHRDIKPENLLLGINGELKIGDFGWSVHAPGNRRTTLCGTLDYLPPEMIEGREHTAAVDLWSLGVLAYEFLVGGPPFEESGHSATYRRISRVDYSIPSHVSPEAQDLISKLLVHEPEQRLSLEKVQNHPWILKYKKSSRSTGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H9</accession>
    <name>I4Y6H9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_48824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960369.1">
        <property type="nucleotide sequence ID" value="XM_006960307.1"/>
    </dbReference>
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        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6H9"/>
    <dbReference type="GeneID" id="18472469"/>
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    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243453_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6H9"/>
    <dbReference type="OMA" id="GSTDWPA"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1623" mass="182428" checksum="5DF4E937B52EA61C" modified="2012-09-05" version="1">MQDDKNYLYALKNKILHPVDEPQSNTSSAKSKPKIKTPKQSNKRSAPVEESPVMKRQPRPITSPSIRSEKSPEKNVKEQSLSKKKVKFEDPVSPKKMKLEKSATPLSTDDKFMERIVTQNSHLQRMSKAMPQRKTVVTTDGSTTSIDKHSLEKLKELISDIFDAEDSLISDSEVPKVYTKCIKGDGSLQPSITKELSSYLNQLYASKPNSILELANNEFDGTTQSELVTKLARLIKILDKSVMLGDKLSVWNPENQDDFDESIDNLHLATESIAAVECILLIMKFDQLPKQLYFEDILSHCLSVFKYHLNKTIYAYVEAIEEGYSNPSNILAYAARKNPQPIKKPLSILFNTITSVIPSLNALMSLSHVSLGDSVLITATYISIGPFFVAEPTSLRDMSVKNALSPIGGGNGMRELRLIALTLIQNIFANYDAQRNWIIDEILSAAIKLPELKKQSRQYQLKSGKTIYTLSALLLQLVQACSHSTYEKINNLRYKHQLNVLEEEAEESTKTEAYTEFVKSEVALWESSLYATANIAQAICYQLITHLCQSKSSKSSHEADYKLILENLINDTLTVLYLPEWQGASWLLLILLRLMERSVLEDNTTSNTEVVNIKSIALDHFGNIFAKLRQVDLERIEYNEKASLSQLTDIERAVWNGDLDELSRLHTIHQTLMGTLFINGSQDDLCISAYELLGSSWGYYVVKGLKASQSKVDNNSESEAILKEQSIVQEKLLTYIHSIWIEDDYDLDAISRDRQNMDELENTALQLTSLSPLQKMQDVVLYVIIQSFTSKSVSVRARAVKALGLAIMSDNTLLNDIRIQNCIGSRVKDVASSVRDAALDVLSKHLTIDSGFVNDYFEIVSDRIDDESPAVRKRVVKLLKDIYVSTDDLERKAEIGKMFCMRIVDEDDLLKDLALEVLDNLWLNLKITKSSKATKDDHFDADEEVASIDGVVDVLMEVTKLFGDRYNLLEQAMEKIVSRHPKSHQLQISNRFKHVVAVLIERIDNNEEDSDLLACVRTILVLAGTIKGVVGGAAAEQLLPLLVNGITPEQKATSEATLKVFKKIIPLLSRSSTKLTADLQDRLLPLISSPNNGIAALSEAVACLCSVVNTHTYAFVSLSRMLMKAALETHQLLDERTRTVDGISKCKVLIIIMGLLVEHCDFESVRNYDDMNISRRAQQQYYNAACDLDKLVASLAPEENERGVAIQDLIWRLLIDVRRVVDDPAIQAISLRGLGCIFVGYPYLMNEEESIAIMDNVFADTSPTKRIDHSQLLLVFQEYLKVDEQKKNAKVDEVDAKQNAITVEHLIGDADQLNDSNVGPRILQRYLKPILASALSNTANTSLPAIDVLGYVVKQGLTHPIDLVPTLVALQTSPSGAISAKARDLHVTLYNKYASVLNTHHILTIEKAFDYHYLITGNLSGMRNNRALLETWFGLMSEKRPAKLDFLSGILRFFDKNPATTTVTDHSIQLSRFIADNLLTFNYQHNEDVLFVGRMLSTYIATHGEQLRDDIENADTNQNERRLSVIYSICIAVRNNLKSMYGFTDKQFIEYKPKKKSTFGDRQITSRDEVKQIPYDIIPGATKSMKSDADHEAQIQAYFDLMNDIGDQMNTLDSDEDEAMESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6I7</accession>
    <name>I4Y6I7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960377.1">
        <property type="nucleotide sequence ID" value="XM_006960315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6I7"/>
    <dbReference type="GeneID" id="18474510"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61399"/>
    <dbReference type="eggNOG" id="ENOG502RXJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6I7"/>
    <dbReference type="OMA" id="SFARCYF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33168" checksum="B3B80BE17AC0AFCB" modified="2012-09-05" version="1">MEYKNYLENDGYVIIDGFIDSQEIDKLRQAANDAINLTRTHNWPYRRVVGKQFPPWTDEDSPDSWGVQHLMHPDLKMPIFRQFYASDKLVELAANLVGCSPEYLQMELFNMLILPTRSSFNLSWHRDHVLHSADEQEERDALTTPHYGVQFNAALYDDSCLWIVPKSHKMVRSPAQRALSCETKPADNPAEMPGAIQVHLKAGQILFYDANILHCAQYPCTPPSPPRATLHGSYGDLRGGSHRAIGVLQHGLEWMKDPSFGDGPGHEMWEKLMAMYNQAKADDKLGKYSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Q5</accession>
    <name>I4Y6Q5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HSP90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HSP82</name>
        <name evidence="11" type="ORF">WALSEDRAFT_33903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960310.1">
        <property type="nucleotide sequence ID" value="XM_006960248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Q5"/>
    <dbReference type="FunCoup" id="I4Y6Q5">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6Q5"/>
    <dbReference type="GeneID" id="18471771"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33903"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="I4Y6Q5"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="699" mass="79800" checksum="B5265444501DBDB7" modified="2012-09-05" version="1">MSQTTHQFQAEISQLLDLIINTFYSNKEIFLRELISNSSDALDKIRYSSLTDPSVLDSQKDMFIRLTPIKDQKCLIIRDSGVGMTKADLVNNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSAYLVAEKVEVITKHNDDEQYIWESSAGGTFTITQDTTNPPLGRGTEMRLYLKEDQLEYLEEKRIKEVVKKHSEFISYPIQLLVEKEVEKEVEDESAEAKTEDDKPKIEEVEDEDAKKEKKTKTVKETVKEEEELNKTKPIWTRNPQDISNEDYASFYKSLTNDWEDHCSVKHFSVEGQLEFKALLYVPKRAPFDLFETKKKRNNIKLYVRRVFIMDDCEDLIPEYLNFIKGIVDSEDLPLNISRETLQQNKILKVIRKNIVKKCLEAFSEIAEDKENFAKFYEAFGKNIKLGIHEDAQNRAKLAEFLRFHSTKSGEEQTSLKDYITRMPEVQKNIYYLTGESLSSVKDSPFLEVLKKKGFEVLLMVDPIDEYAVTQLKEFEGRKMVCVSKEGLELEETEEEKAKREQEAKDYEDLCKSVKEALGDKVEKVVVSNRIQDSPMVLVTSNFGWSANFERIMKAQALRDASMSAYMASKKTLEINPQNSIIQELKRKVQEDSADKTVRDLTFLLFETALLTSGFTLDDPTSFAKRINRMVSLGLSIDETEAVPAATENKDDVPPLEGEGAGAMEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U2</accession>
    <name>I4Y6U2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_70367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960192.1">
        <property type="nucleotide sequence ID" value="XM_006960130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U2"/>
    <dbReference type="FunCoup" id="I4Y6U2">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6U2"/>
    <dbReference type="GeneID" id="18475724"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70367"/>
    <dbReference type="eggNOG" id="KOG2896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074437_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6U2"/>
    <dbReference type="OMA" id="QMRIDYK"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="259" mass="29510" checksum="C2308E514F63C11F" modified="2012-09-05" version="1">MTYTKSESFDQLIRNATLVNCNSEISDEVRELDDKISTHTSHIQLQRSLDSLTRKNSLLDNRLSDLESAIDSYRNSINNKHSQLQARRRNLARLSNQQQHDDSDEIERSVTLKVSVDQLKKQTKIQRIRLLKDLSALFPIVKVDDSNNLTFSILGLSISENVISSSSHAQTSSALGYSCLLTCLLSKYLNVYLPYDIVYKGSQSVIIDPVSNIRGSNIFPLDLFFKKDQMYRFEYANYILNKNIEVVTHAIIQLTLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y757</accession>
    <name>I4Y757_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_33798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960133.1">
        <property type="nucleotide sequence ID" value="XM_006960071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y757"/>
    <dbReference type="FunCoup" id="I4Y757">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y757"/>
    <dbReference type="GeneID" id="18471748"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33798"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y757"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="548" mass="59445" checksum="3D81722AA0D13FCF" modified="2012-09-05" version="1">MSLKIPKSQGIDLFKPGGKQLSGIEDAVVRNIQAVNELSEIVRTSFGPNGKNKLIINHLDRLFVTNDAATIVQELEVVHPAAKLVVMASRQQEQEVGDGSNLVLILAGELLKKAENLLVMGLHPSEIVQGYELARNKALDSLAELENDKLELPVSKDSLVKSIKTSLGSKQFGNEDFLSDLVADAAITVMPKDPSQFNIDNVRVVKIMGGNLYESRVLRGMVFGRQPEGVARNAQKAKVAVFTCGIDISQTETKGTVLLKNADEMLNFTRGEEQQIEKILKEIADSGVKVVVAGSQVGDLALHYLNRLDIVVIKVLSKFELRRLCRVVGATPLARLGAPTPEEAGHIDVLETTEIGGDRVTVFRQDNDQLTRTATIVLRGATANHLDDIERAIDDGTNIIKTLLMKDPRFISGAGASEIELAKIIENFGDKTPGLNQHAIKKFAQALEIIPITLSDNAGLNSTEVLSKLWAAHSTEEGKNMGIDVDAISDEGLIDTKSLGIKDSLAAKWWAIKYAVESAIAVLRVDSIIMSKAAGLAPPQQQGHWDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C8</accession>
    <name>I4Y7C8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_33693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960012.1">
        <property type="nucleotide sequence ID" value="XM_006959950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C8"/>
    <dbReference type="FunCoup" id="I4Y7C8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7C8"/>
    <dbReference type="GeneID" id="18471731"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33693"/>
    <dbReference type="eggNOG" id="KOG4103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118199_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7C8"/>
    <dbReference type="OMA" id="GLQAYGI"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="122" mass="13596" checksum="84C8B02707B7D066" modified="2012-09-05" version="1">MAQRFIDQGLNILRRVGGGVEKALGSYKEPVFYNAQVGKELFKQVYQAEKLSPPSSFSQVASTWSNIFAKAAQRQTYVQLFESGQWSKVAVIGLEAYGIFKLGEIIGKRKLVGYGPKAQEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7I5</accession>
    <name>I4Y7I5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960066.1">
        <property type="nucleotide sequence ID" value="XM_006960004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7I5"/>
    <dbReference type="FunCoup" id="I4Y7I5">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7I5"/>
    <dbReference type="GeneID" id="18474425"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61260"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y7I5"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="24659" checksum="259B2ED4B3505270" modified="2012-09-05" version="1">MSEDIVVDTTTPMVSTSNDTMDQDDVPVFAPAKKTATAGPDLKGQTRRVLIPGHRMSPLKKDWVNIYGPLVEMLKLQVRMNPQKRAVELRSSKHTKDAGHLQKGADFVKAYALGFAVEDAIALMRLDDLYIDSFEIKDVKTLHGDHLSRAIGRIAGQNGKTKFALENATRTRIVLADTHIHILGAFNNCKLCKDSICSLILGSPPGKVYNHLKVVGARLKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y831</accession>
    <name>I4Y831_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959844.1">
        <property type="nucleotide sequence ID" value="XM_006959782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y831"/>
    <dbReference type="FunCoup" id="I4Y831">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y831"/>
    <dbReference type="GeneID" id="18474353"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61134"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y831"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="655" mass="72691" checksum="0C61A7CFD198D35E" modified="2012-09-05" version="1">MKYVGLISGGKDSIFNLLHCRNNGHELIAVANLKNGGAYEEMDSYMFQTVGLSILPLIAQSLGVELYEGLIKGTPINQQSTYEQTLNDETEDLFELLQTVKTKHPDLEGVSVGAILSNYQRVRVEHVCSRLGLTVLAYLWRRPQDKLLDEMVAAQQTSVVIKVAGAGLDPERHLGKSLAQLRPTLDKLHNLYGSHVCGEGGEFETVTLDSPLYKQRIVLDDVEVIYHDPSPNAPVAYLRINKAHLEDKDEEQDVHFSEPEILDEISQEIQPPAVLTSNTDGMSLPRRQGVQPPCSTKVSSNWLTISNVYSTNAGDISTQTHDILQKCSALMQEKGFIIDEHTTFISVYIADMSDFSALNEAYGTYFQKSGPPARACIATNLGETYKVAISLVAKKDSSRSALHVRGQSYWAPANIGPYSQSITINNRHFISGQIALKPSTLSLVDGGVSQQAILSLQHARKVSEALAPVHITAGELLMRPESVICYVTSRDYVSICQNVLQQAIDAHSERSEDCLDVITQKPAQLYVVVDSLPKNAAVEWQFVYNDRPSQISYDSEDEDAQKEDALNVTYNEDKLIRKHHARSHEGVQCFEFLQEVTTNSINNSIYCTVYYTPLVSLDEAQKCIDGDATFVPVKGIFDKNIKEAKIALNYFVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y864</accession>
    <name>I4Y864_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959877.1">
        <property type="nucleotide sequence ID" value="XM_006959815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y864"/>
    <dbReference type="STRING" id="671144.I4Y864"/>
    <dbReference type="GeneID" id="18474361"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61154"/>
    <dbReference type="eggNOG" id="ENOG502QPN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019746_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y864"/>
    <dbReference type="OMA" id="VVPWMMF"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="555" mass="63008" checksum="23A7CCDF7B2DEEEB" modified="2012-09-05" version="1">MSETRARVLIIGAGCSGMAAAYSFSLEPSKFKVTICDKVQNVGGSATSYELEDRNKFGAEYINDGVQGASPVFYNTLSMFENILGFRASNVGMQISFGKGKESFWTNVFPSELVENYHDDIKKFGKVLQIIGRFEPIFALIPVDKMLKMFGFSPSFGDRMVYPLVALFFGTGNETKHISSAILERVFLDPSMRLFEFSQDSLLASIPLMKAFPELGRVYGAFKSKVMSNGNVKIFTSREVTSVERGTKKAKEMGGNILATYDNSDFFETFDDVIFACEADNALKILESGSGATWREKKVLGNVLYKWDVTVTHNDLNYMRKHYQVTYDSQYFAQRDDENSKKAFKFAEKNWKPLYLIKMYEQDPSQIEMSFDLTHYQAQFEGMPPVGSDADIKAEDAPPTERQAGSEGKENAKGVDSDGLVDVQNKELPSLENHVYQTIYLDRDASERWTKDEVASDKIILEKWWKQQSHRWQHYGGTVPWMWTINGRNNTHYAGAWTLVNMHEVAMVSGFAAAYQLGAPYPFKQDENCARLFRLYLLLAHMSRMRGEDRKGMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8B4</accession>
    <name>I4Y8B4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_47854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959694.1">
        <property type="nucleotide sequence ID" value="XM_006959632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8B4"/>
    <dbReference type="STRING" id="671144.I4Y8B4"/>
    <dbReference type="GeneID" id="18472431"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47854"/>
    <dbReference type="eggNOG" id="ENOG502S5WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078271_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8B4"/>
    <dbReference type="OMA" id="VKIEQWL"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="25321" checksum="53FF37F4C562BDDC" modified="2012-09-05" version="1">MSFFKKFSYTLPVSLSAIAYAGLSRQSIRCSSTTGSIWREGNPSAPRASPYPLVFIRTPQSWGEDQKEFQSTQGLLIQKGFGCLEIFCDEHTGSTSKEILKKMADDVQQRIRLAAIPFPPVLFAKGLGTLVAETHISDFPVSGVVLINPPLIEDEKSPNESALPSPVEPFNYEAFPRIGIMDKLANVEKLEKHRLANSDADLILYNGEYGEQQSLYEVERWLDDKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8L5</accession>
    <name>I4Y8L5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_33371</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959564.1">
        <property type="nucleotide sequence ID" value="XM_006959502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8L5"/>
    <dbReference type="FunCoup" id="I4Y8L5">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8L5"/>
    <dbReference type="GeneID" id="18471663"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33371"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y8L5"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
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        <property type="entry name" value="Dynamin, middle domain"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Dynamin"/>
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        <property type="entry name" value="Dynamin_GTPase_CS"/>
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    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
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        <property type="entry name" value="Dynamin_stalk"/>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
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        <property type="entry name" value="GED"/>
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        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="679"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM20307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="781" mass="87107" checksum="B62872DC1DFFC5D1" modified="2012-09-05" version="1">MDDIISIVNRLQDTFNTIGGNAIDLPQIAVVGSQSSGKSSVLETIVGRDFLPRGSGIVTRRPLVLQLIHTTKQEEYGEFLHIDKRYTSFEEIRNEIQSETFRVAGQNKGISKLPINLKIYSHNVVNLTLVDLPGLTKIPVGDQPSDIEKQIRQLVLDYIQKPNCVVLAVSPANVDLANSDSLKLARSVDPQGRRTIGVLTKLDLMDAGTHALDVLNGRVYPLKLGFIGVVNRSQQDINSNLDINEARRREDEFFQESPSYRNIAHRCGTKYLAKTLNNVLMNHIREKLPDMKAKLNTLMGQTQQELNSFGDATFFGKPHRASLILKLMTQFGRDFVSSIDGTSSEISTKELGGGARVYYIFNDVFGRALESINPNQNLSNHDIRTAIRNSTGPRPSLFVPEVAFELLVKPQIKLLEPPSLRCVELVYEELMKICHNCTSPELSRFPRLHAQLIEVVSDLLRERLGPTSEYVQSLIAIQSAYINTNHPSFAPGTAAYAAEAQKEKQKQTPSLRFKDVQNVIEDGEEKDNELAIEHRSISQPSGTQEDPRRHSITNQLLNGTSTPESDSALMNHHRNRRGHQAQQSQSQTARDTFLNYFFGGADAASSAPANTSNSTRTPVRDVDEEARHYASTANPLNGRSGLEGSAAAYDMKSLGKHLEPVPMIDEGGSAVSEREDMETTLIRSLIASYFSIVRQTIEDLVPKAIMHLLVNFSREVIQDKLVASLYNPDMFDELLYEDENIVNERTRVKNLMDAYKQAFQVLAEVNMPKQSNMVPPTQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8P1</accession>
    <name>I4Y8P1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">21 kDa subunit of NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959590.1">
        <property type="nucleotide sequence ID" value="XM_006959528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8P1"/>
    <dbReference type="STRING" id="671144.I4Y8P1"/>
    <dbReference type="GeneID" id="18471670"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33395"/>
    <dbReference type="eggNOG" id="ENOG502S2AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081626_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8P1"/>
    <dbReference type="OMA" id="PHDPHAY"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="20104" checksum="DDB62DD61670ABCB" modified="2012-09-05" version="1">MRSTLRLAEKVADHAKYHQEPKGIWMKAKQWLAVNPEISSGLINHHQFRKIPPGSRPEKYVQPISKSSDIAENPYFKRDVRRAFPKTSHVSQNELAQLLISNPDFKALPNPAEAQTKALAQVKDSPETLDLAQVLDVLPAAQSPYTGLPPTPPFRPNPMRETVGAPSKEGAYYPMRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8U4</accession>
    <name>I4Y8U4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transcription regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_33426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959642.1">
        <property type="nucleotide sequence ID" value="XM_006959580.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y8U4">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8U4"/>
    <dbReference type="GeneID" id="18471678"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33426"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_29_2_1"/>
    <dbReference type="InParanoid" id="I4Y8U4"/>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="209"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="409"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="705"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="979"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1377"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1385"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1402" mass="161314" checksum="0CDFA41ED1C6B169" modified="2012-09-05" version="1">MSGENYKEIEEDKRSNGSSDAEGESDTQVNQFKDDEFIEDDPSLSSKLENEKIDLSYVDPDLYGLRRSGRSSKTQSVDPTYLDEFIDDDEDDYSDAPKRKSRKPTRRQPRKEAPPPRFDESSEDEYFTSATSKKRQRNQRRAQSSDEEEEESFDEDDDPGAFRASSRGNGVTNYNEELMAGFETDESERMEAEIVPAVEPKVGERPPEFEIETVFGHSRDATNAPDVDDDPFENIRFHIKWRGFSHHHNTDETYEFLKRCKGIKRVDNYIKNIYNYQHDITVNRDHNKEDYEIVEMEKERLKDLVEMYRKVERILDQRDSGTTTEYFCKWTGLQYSECTWEKHDDVSQYAPEQIDAYLLRTASTTVPNRSANYNRSRPAFRTLMESPDYIQVTGGELLDYQMTGLNWLAYLWSRMESGILADEMGLGKTVQSIAWISWLFHERQQYGPFLVVVPLSTIPAWQAQFMKWAPDINVVCYNGSGKSREVIREYEFGDYKKLKFNVLLTTYEFCLKDRAELGQMRWQALLVDEAHRLKNSESQLYETLFSFVTNSKLLITGTPLQNNVKELSALMHFLMPERYSITGDFELTDEDREEKIGQLHDQLKNIMLRRLKRDVIKSLPTKSERILRVELSSLQTHYYRNILTKNFTALKSSEGGGPAMSMMNIANDLRKASNHPYLFDGAEGSINAKDEVLRGIVMNSGKMVLLDKLLARLKADGHRVLIFSQMVRMLDIISDYLSLRGYMHQRLDGTIPSEQRRKAINHFNAENSPDFAFILSTRAGGLGIDLQTANTVIIFDSDWNPQNDLQAMARAHRIGQKSHVSIYRFVSKDTMEEDILERAKRKMVLEYAIINQVDTSGKNIGQPKSAKQQPDNFSREELSAILKFGAQNMFKTDDKEQNKKLAELNLDDLLARAEDLESDKAVGGSSLGGQDFLQQFQVQDVKNDTSWEDIIPAEERDKLDDEQKEELKKQTEAELQEQFGKRAASKVQPGTYKTGDAPSPKKKEAPVVQKKTTAQRAIELKERDLRNLIRGITRFGDIRVRMDDIVKDSKLEGKNRTVLIKTSDELLHKCKEAINEHNAELRARASAGESITQNDRQKAVLIDFKNISGVNSYTTYTRYKELSFLHDVLSGVGNSLNWRLPIDKLKSVIGWACDWSAKDDAMLLIGCWRHGLGNWDTISNDEDLGLQGKLFLEEGRGKTKKEDKKIPNAVHLVRRSDYLLGELKKALEKEYNAKEHSHPSGTPQNTYAHGHGSKPVKSSRTSPSHNKKKEDQHGDSDDGTESMDEGIMKEHMRPVRKQLKSLKYEVDTLKGQEKLKLLKECLHAIGTRIQDLILESNDKEKTRKHAWIFTTLFWPKEVKYTQLIEIYQKMVGQSATTSTGVKRQHSYENSEQKEQEIKKPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8W8</accession>
    <name>I4Y8W8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FSH1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_65315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959436.1">
        <property type="nucleotide sequence ID" value="XM_006959374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8W8"/>
    <dbReference type="FunCoup" id="I4Y8W8">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8W8"/>
    <dbReference type="GeneID" id="18475010"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65315"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y8W8"/>
    <dbReference type="OMA" id="EEPRGWW"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="257" mass="28674" checksum="80197FF89F040D9D" modified="2012-09-05" version="1">MAKPQILVLHGYTQSAYIFSKKIGAVRKALRDCCDLHFIDGPIELDKSDLPNAEMYDSMFVDSAPRAWYVTRKNHKTDNTDFERFDESWTEIKELLSKQKFDGILGFSQGAGFAAALSAVLVNPDLRPEFKDVHPPFKFCITVGGFKIHDKAYDHLYPLPVSGDKTHFLHVIGDNDMIVTPERSASLVENSPNGRCERHPGGHFVPSSAPWRHFFLRYIDSFNEGGSFGNVEGPQPTPESLVAKSLQGTPSSQSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8X2</accession>
    <name>I4Y8X2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_55052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959440.1">
        <property type="nucleotide sequence ID" value="XM_006959378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8X2"/>
    <dbReference type="FunCoup" id="I4Y8X2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8X2"/>
    <dbReference type="GeneID" id="18472711"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55052"/>
    <dbReference type="eggNOG" id="ENOG502QUNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006117_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8X2"/>
    <dbReference type="OMA" id="WHPLGVH"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="605"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="86276" checksum="583AD89DD25FF5DF" modified="2012-09-05" version="1">MEYQEEWLENLIEAFAERKSDIQQLNDSKSNKLAIRNSDLIFAERNEIKIMSLSELKASDPSTSNINLKTLHTPTITFDIQSLVLNSTKKLLAVVGSHQVVVVVLPRPGYSKLVTPLIECRSIQVGQYYHAIKGSSEIAKVDWHPWSLSASSLMVLTRDANFREYDISIDSEDPQQSISFVQAAAMPGSVTNQQFSNKSKGFSADDERSTECVSFDIGRGDSDWGPLTLYGLMKNGDVFAICPFMPNNAQVPTSYIQNLKGITEAKLMKVTEDSLIEARLSQQMRWLNAVVKQIKLGEENIAGFKCNPPRATGSLLRQGPYLVQPAPTDEEYESDASDILIIRPKDCPVDIFVVAFTDGRVDICLEVVKAEGRWSSKAESHATPPIISTYESIKILQSHDFGYPTLSKDPIYEDTIYISHAEGVHALVFKPWLDELDQVDSLTRDSTLVHVIRTSTTSSAQSTPIVALDVINDAYLGYLLFALTNTMQILPLDLSLRVQTDPETIETKPKPQMLPKVSDSATSKPSSSNQASNEERKLYSSLLESPFIQDQPDGSNKINLSHKLAPVNTRAEIQVTPQTLRYMGGVVENVRHHNQNSIQTGNNIQDRLSLQLKETEKQIEKLAHVAKIATNPSNEAGVGTGKGARVEKVSNEQSELLKRMDNLLQRLMDKHQPTLSTHEKKWFAELGRIRDEVSGTDSKGRALQARMSRLSHQLELLKPQVQSYEATEAMKRSQTGIIGSSQIAKVESVLQDETKAIEELRVKLDTVTKLLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y926</accession>
    <name>I4Y926_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959494.1">
        <property type="nucleotide sequence ID" value="XM_006959432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y926"/>
    <dbReference type="STRING" id="671144.I4Y926"/>
    <dbReference type="GeneID" id="18475014"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65370"/>
    <dbReference type="eggNOG" id="ENOG502SCAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092489_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y926"/>
    <dbReference type="OMA" id="QPAPDEC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="193" mass="21575" checksum="6A07439DE1FFE8AA" modified="2012-09-05" version="1">MRILRQFTTTTRIERSGRNLNSLWSKLQREDFDSISTEPSTVSFQTPTTNPTDLSHDKEDKSVDTTPSNAYIYIEGVRIPKKPSQPSPEECCMSGCVNCTYDIYADDLASYLSAAPKTASELEAKGIDISRWPADLKGFAGAKAATSQADAEIEAEKAADKLVSDLDPTMRAFLEMERNLKKKKKQVEREQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y933</accession>
    <name>I4Y933_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_55089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959501.1">
        <property type="nucleotide sequence ID" value="XM_006959439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y933"/>
    <dbReference type="FunCoup" id="I4Y933">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y933"/>
    <dbReference type="GeneID" id="18472713"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55089"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021795_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y933"/>
    <dbReference type="OMA" id="IVMTSFY"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="138"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="246"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="391" mass="42611" checksum="F955FC9286E7C1DF" modified="2012-09-05" version="1">MAGVQRAVAFPGQSSFSNLPPTLEDFNGARASRRVFIGDLKPNHNEENLTKLFNDKMSTIDQVAKIPGEPVVNVTVKHDRGYAYIEFRNTDEAAYALQFDGTIFQGEGIQIKRPQEVLDELQRKQGHTVSGTVPDSDQKIFVGSLPTFLNDEQVMELLGSFGELRSFNLVKEGTSDVSKGFAFCEYMDPALTDIAIQGLNGMEVGDRKLVVQRSSTGPMGKIGVGGTSSIAQILPLASETQAYRTNVLLLLNMVTAEELKDDLDYQEICEDIQEECSQYGEIIKIKIPRPPRPDDPVFSTPGVTLSSGEDLRFEAASEELGVGKIFILYKTEEQASKALKALAGRVFGGRTVIGAYGKPEDVEDAPLPPELPNDDAPLPPDEAIPPPPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y973</accession>
    <name>I4Y973_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959541.1">
        <property type="nucleotide sequence ID" value="XM_006959479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y973"/>
    <dbReference type="GeneID" id="18475654"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69867"/>
    <dbReference type="HOGENOM" id="CLU_2869376_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y973"/>
    <dbReference type="OMA" id="STASHCH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="64" mass="7609" checksum="99A95164E640A2FD" modified="2012-09-05" version="1">MDLNFNCGMRRGVMPKSTKLNPFFNAYQQKQQKQPQKRKGFDIICNNMPKEFSLNLTQEELARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y993</accession>
    <name>I4Y993_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_47315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959331.1">
        <property type="nucleotide sequence ID" value="XM_006959269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y993"/>
    <dbReference type="FunCoup" id="I4Y993">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="GeneID" id="18472415"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47315"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_3_2_1"/>
    <dbReference type="InParanoid" id="I4Y993"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="277" mass="31586" checksum="AAD9E7A731C8173D" modified="2012-09-05" version="1" fragment="single">MSGIEKLVDTHCHPTDSDNVNLSEHTRKMHAVCAMSTHIEDQDKVRELYKGYPDKVIPYYGYHPWWSHLFTFEENISKEEHYESILLDGKKDDIKREQLSGLLDTLPTPILFQNLLIDIEERLQDNPRAQVGEVGIDRVFRVKGEDGKLTILQPSIEHQKRVAVAQVKLAKKYNRLVSMHSVSATQGSLDIIRAADYQRIVLHSCGIGHNAITAARKEFPDIYFGFSKAINARSMSLLEDSISVTPLNRILTESDFYDEAHFPVQVGEMVDIIARIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9J4</accession>
    <name>I4Y9J4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF410-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959420.1">
        <property type="nucleotide sequence ID" value="XM_006959358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9J4"/>
    <dbReference type="FunCoup" id="I4Y9J4">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9J4"/>
    <dbReference type="GeneID" id="18474232"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60894"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9J4"/>
    <dbReference type="OMA" id="VKWSVKA"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36044" checksum="F2DD8479EE48653B" modified="2012-09-05" version="1">MIDKYLSSIKPLLDSNDNYSAHQRVRTISTRLSKNGKSKESIELLFTVSKSLLEKSEWGSAIDCSILMLNQLSNLNDWDLSLVTQLISLTTNENSWRKKLIDNAITTSATSFKIPSGHPDLLDFIGNLYYKERSYPLAEYYLILASKKESAVTLAKLYIQWSQSPNQHHNDIGRYALRGVLAFILAEQVEAAITFTLNFLIQLQLTNSTIFLENQSLDGITLTHSHTLNFAQFIIASIQRSSTSNIAQEWKSLVSHFKNKSDIINSQPVAQACTEIGSLYFDIRPVNTGGNMMDIMSSLLGGGAPSNQSKLKLLNKNSAAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9V3</accession>
    <name>I4Y9V3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_65165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959274.1">
        <property type="nucleotide sequence ID" value="XM_006959212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9V3"/>
    <dbReference type="STRING" id="671144.I4Y9V3"/>
    <dbReference type="GeneID" id="18474995"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65165"/>
    <dbReference type="eggNOG" id="ENOG502SBJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2689697_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9V3"/>
    <dbReference type="OMA" id="MEAMSAK"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8473" checksum="64FB15F249265DEB" modified="2012-09-05" version="1">MVKIAWGRWAFWSSIIVGSGYGLMVGLTPSDEELYNKLSPDLQRRVDQQRKQRLQLEKQGDLEKANALPTNKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA08</accession>
    <name>I4YA08_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_57874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959065.1">
        <property type="nucleotide sequence ID" value="XM_006959003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA08"/>
    <dbReference type="FunCoup" id="I4YA08">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA08"/>
    <dbReference type="GeneID" id="18472960"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57874"/>
    <dbReference type="eggNOG" id="KOG2318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010564_0_1_1"/>
    <dbReference type="InParanoid" id="I4YA08"/>
    <dbReference type="OMA" id="DHDFAID"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="168"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="653" mass="74705" checksum="F67FFDAADA995CE3" modified="2012-09-05" version="1">MAKNDQRFKGTANNPKFHKPKKTQQKVVLDDRFKDLFEFDKSTKLDKYGRKLKSKDDAEQLKQFYKLDDTDKMDFARGEAVMEDSSDSSDDSGDDPADSSDDDDEVELQPENYENKLIGSDEEESDEEEEDSPEALDDDEIKDEMRRLDAQAEAYNDGHVEEETIDFTTRLAVTSLDWDHLSATDIYVALDSVMQTTDLKKSLKNVKVYMSQFGRKRLEQEEQSGPALVSTKKSKKGKEREVDPDSALREYQLGRLKYYYAIVTMSSSKAAHKLFTEAQNTEIERTANVIQFEVVPDGVEFDEVDIRDQASTSSEAYKGVDFTTPALRHSKVKLTWDEDDDKRVALTRKRFNQADIEQNDFKAYIASDSDSDDDDETQKKRAALLRAALGGGGADDARELRGGKKDREGEMEVTFAPGLSEKVDKNDDESDEENMTTLEKYKKKEKQKKNARKEKKKAKDNAGEEEEEHVPVQDDAGFDDEFFQSGSEDEAAFENRRDDEGITKPSKGGKKDKKAIKEPKDDKSRVESTAEELQLLTNEDDEKHFDMDEIIKKEKQSNRKRKHRKTKEENTKDDFEIDIQDDRFKGVLDDHQFAIDPTLPNFKATKNMKKLLAERSSRSQANSGQDFNADNDRSINSLISSVKQKSNKKLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA76</accession>
    <name>I4YA76_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_19909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959047.1">
        <property type="nucleotide sequence ID" value="XM_006958985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA76"/>
    <dbReference type="STRING" id="671144.I4YA76"/>
    <dbReference type="GeneID" id="18470815"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_19909"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049222_2_0_1"/>
    <dbReference type="InParanoid" id="I4YA76"/>
    <dbReference type="OMA" id="PENDWVV"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="258" mass="27896" checksum="107F98B4FDC7B2B1" modified="2012-09-05" version="1">MSFLIDQPAVGYYYYLKKDKEAEPETSEIGRPLKDDEIARWCMITGTPASVANLALTNIVPDADLVISGPNYGRNCSTPLVLSSGTVGGAIGSAIRGRKAISLSYGIMSNPVSPEAVGQANEIACNLINHFIANWNDQVDIYSINIPLLPDLRKSVAKYTTIQKSSFERLFLPSSPSDPTKPIVNKPVIEDGAPLSFAWAPDIKALIECAPETLDKDTDSHCLSEGNISVVPLKANYETCYSSTKDLTLPPQGSQIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAA8</accession>
    <name>I4YAA8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_33098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959159.1">
        <property type="nucleotide sequence ID" value="XM_006959097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAA8"/>
    <dbReference type="STRING" id="671144.I4YAA8"/>
    <dbReference type="GeneID" id="18471620"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33098"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_3_1"/>
    <dbReference type="InParanoid" id="I4YAA8"/>
    <dbReference type="OMA" id="NHNRVHR"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697541" evidence="3">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="342" mass="39040" checksum="B24039BCFE695840" modified="2012-09-05" version="1">MKYTSLAIALLANSVLSQTCENISVRRDWNNLNDEEKASYISSVKCMMDKPSLSINGQTQASLHEDFTFVHQYPGYAIHWVARFLPWHRWFIYAYHKELQECGFEGALPYWSWENDYQNLTQSAIWDSDPIIGFGGYGDFDYDNIYNSTIITDGAFANYEVNFPFNHQLTRNLKLSETYPSDGPGPYAQRGYDPVNMNNLTTIEIFEEFASSVESPPKQYNPYGYPGPHGAIHLAVFGDMATDGANNTAPNDPLFYMHHSNVDRVWASWQNLNEENVFKYAGNTDFYWESGIRSGLPATLEDPLLFAGVGALDSDDLQVKDVMNTTEWPLCYTYEDLSPWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC2</accession>
    <name>I4YAC2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_64809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958912.1">
        <property type="nucleotide sequence ID" value="XM_006958850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC2"/>
    <dbReference type="STRING" id="671144.I4YAC2"/>
    <dbReference type="GeneID" id="18474958"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64809"/>
    <dbReference type="HOGENOM" id="CLU_726048_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAC2"/>
    <dbReference type="OMA" id="DQESTSH"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="381" mass="43126" checksum="EBE4EAC703C0B731" modified="2012-09-05" version="1">MGYQPDYENPALQALAADMHANLGCYLIGCVLNLILMAILGMQCLDYYNPPDIILEFFPNDSKLNKGVVGVLFVAGFFQSACFFEMLYHPFINGFGDLRVWNDTRWTWWSEPVVSSIIAVFCQAFFLNRCWKVTKSWIVLIVALTGMVAAIAFGVACTYYLAKFVDFTNSNFIESKICASAWLAFSTATDIWISVFLVIHLYRERKRHAGFSTTDRIIASVLAYTLKTASLTSIWVVINLILYCGVTTNFAWSIFQFNMGKVYSISVLYTLLSRIDVRKILSVHNVQVSSSRGRSNDVDHANSAIHIRTEVERDYELDDKTVPPKLQIAPPLQRETSRSTARYSDSEPDAELGFHHRGPQDSIVDDDRSTRALRYNANSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAF5</accession>
    <name>I4YAF5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_29162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958940.1">
        <property type="nucleotide sequence ID" value="XM_006958878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAF5"/>
    <dbReference type="GeneID" id="18471083"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29162"/>
    <dbReference type="HOGENOM" id="CLU_2016980_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAF5"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697546" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="123" mass="14000" checksum="09081C2CE6ECA1CA" modified="2012-09-05" version="1">MKTNFIALASTLLIATTAFAVSIHDDKRTPVYISLEDQYEVNLEQRLNSKIKVEDFLFLNDQVEFEADKNEIEALIKRLVIALEDGGDNEADEDDKRGLDLDVKILKADKEEITGKHNYGAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAG7</accession>
    <name>I4YAG7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NatB N-acetyltransferase complex catalytic subunit Nat3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_46777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958952.1">
        <property type="nucleotide sequence ID" value="XM_006958890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAG7"/>
    <dbReference type="FunCoup" id="I4YAG7">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAG7"/>
    <dbReference type="GeneID" id="18472399"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46777"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="I4YAG7"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="20433" checksum="C7FCA3D08759F2AA" modified="2012-09-05" version="1">MTTIKSFKSTHLLKINKINLDYWTETYSISFYQDYLIRNPKLCLSISHPDDSLMGYLFGKIEGRNKELHGHVTALSISPLYRKIGLASLLMKKCEELSNNLDKCYFVDLFVRLTNSNAIKMYTKLGYSVFRRVVGYYGDKEDAYDMRKCLDIDKEGISIRENGHLVRCSPEDTIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAU6</accession>
    <name>I4YAU6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958770.1">
        <property type="nucleotide sequence ID" value="XM_006958708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAU6"/>
    <dbReference type="GeneID" id="18475555"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69245"/>
    <dbReference type="HOGENOM" id="CLU_2051468_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAU6"/>
    <dbReference type="OrthoDB" id="5550090at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="120" mass="13840" checksum="150105F2D1701E4A" modified="2012-09-05" version="1">MKTTEGVKVISTLVRQPAGVESSKQANDPNKSNYEPELETNSRNRDNVMNAAEWNSHLIWARRERGPQFDMNTQMYQFDKQSLDYYTQSSDPSLGAIKNLLNQNEKPATNEDKAGRRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB30</accession>
    <name>I4YB30_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucocorticoid receptor-like (DNA-binding domain)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_46626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958845.1">
        <property type="nucleotide sequence ID" value="XM_006958783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB30"/>
    <dbReference type="FunCoup" id="I4YB30">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB30"/>
    <dbReference type="GeneID" id="18472392"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46626"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_0_1_1"/>
    <dbReference type="InParanoid" id="I4YB30"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11713" checksum="C7EA7923B0399DEF" modified="2012-09-05" version="1">MPTGPSSRVLRDIYRRETVARKEVQRRAYLYVARNTELPFQVRHQAQLSLNAMESASRPTMIRNRCKVTGRGAGLQQGLTRFQFRLQALRDELEGVHKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB34</accession>
    <name>I4YB34_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958849.1">
        <property type="nucleotide sequence ID" value="XM_006958787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB34"/>
    <dbReference type="FunCoup" id="I4YB34">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB34"/>
    <dbReference type="GeneID" id="18474059"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60616"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100687_1_0_1"/>
    <dbReference type="InParanoid" id="I4YB34"/>
    <dbReference type="OMA" id="YDTMTNG"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16443" checksum="760ED891E961FE13" modified="2012-09-05" version="1">MSNNVQLLPSHSKNTTNVNNLHSEYNVPDSLRNGLEWSQVHQAPQHPLQQRLDGWFDHQQLMKLKLERNTYGLGTPMRKMMERKLASSDVSMPAIEDPRNIQKEVLDGVDDQITFADVHRVMEKPSAPTLDIHHQMERKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB49</accession>
    <name>I4YB49_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958863.1">
        <property type="nucleotide sequence ID" value="XM_006958801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB49"/>
    <dbReference type="GeneID" id="18474954"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64775"/>
    <dbReference type="HOGENOM" id="CLU_837302_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB49"/>
    <dbReference type="OMA" id="HTEHPLH"/>
    <dbReference type="OrthoDB" id="10478436at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="332" mass="35183" checksum="32DF5AD2207F4443" modified="2012-09-05" version="1">MEDSLSDANADLGHNLRLSRLLQTSPSISTSPGSSIRSSSAASIFERDIEPGHPIHSGFLGSREAADLSTAPALSGAVEAFVGGHPSDSIGVEMAASNDCNVLNSPSQSFILPPPSPPSLDTQMGKLQSTQSIHSSILPASPPNSPPPSHQPQTPSPLNPHAQHSPRLASQNQSLVGSSSTSPMPANVHDSPASHRISLLSYGDVISERPTSAVPLQTAISHQHAPQSQLLTDENDNQASPASNYVEERNRELERAALSKGLEARLETLSFPESAQISPLQQPSSRNASPVPHLPESTVPVVPSEERFIEEKETVTERGAERLSHRIQSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB53</accession>
    <name>I4YB53_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_38994</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958867.1">
        <property type="nucleotide sequence ID" value="XM_006958805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB53"/>
    <dbReference type="STRING" id="671144.I4YB53"/>
    <dbReference type="GeneID" id="18472091"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38994"/>
    <dbReference type="eggNOG" id="KOG1244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011557_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB53"/>
    <dbReference type="OMA" id="PEHESEM"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15526">
        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone acetyltransferase"/>
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    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="423"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="188"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="287"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="743"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
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        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
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        <location>
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            <end position="790"/>
        </location>
    </feature>
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        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="601"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00010107"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="808" mass="92022" checksum="BFE07BB95B05378F" modified="2012-09-05" version="1">MITCGQCQSSAHPTCLHFTPTLTQNTLSYNWSCVDCKGCEVCKNKGNEDDIIFCDLCDRGWHMHCLNPPMNEPPAGDFACPICLHAGKTLSMQQPAQALPQQQQQHQQPHAYSQHQQHQPYPNAIQANSGANIPLHSPLTSYDFHPPPPLIGNLPTPQQSATILNASKAMLMGRPAPPLFPNFSPIAPAAPKQSKGRGRPRKILPNGPLGVPMTLEEREREKAMIREEKAKAREERARLKELERERDKDKPKNPVGRPPGPRASLSAPKRVSTFIVIDSDEDKMLEDRVQNEQQQGVNQSDDRQQQSVEMHQGEQPMEGVESAPAAGVNTSALPINKSENQEKKVPQGQAQAEPEENDNDDLFGGVLDPYEAQVTYSTPQKDDKERFEIARQKADMKLQIKPKKQQQFLSANPSTPQAEEHKSKSPPIKFLRFGNYEIQTWYAAPYPEEYTNLPSGRMFICEWCLSYRKSEFQMSRHTLKCKYRYPPGDEIYRNENVSIFEVDGRKNRIYCQNLCLLAKMFLDHKTLYYDVEPFLFYIITEHTANGEEFVGYFSKEKRSGMGYNLSCIMTLPIRQRKGWGMFAIDFSYLLSRKEGKIGTPERPLSKLGFLSYKRYWTTAIYKALLSTEQPHTLGQLSELTGMTIPDVTFTLRQNHLIHSVIVGDEKDYVNENNTYRTRTNKPHLEEHPERANNDDPTSVPVPAPNTYKITYNKNTLEAYLAKDAAKDYVRLAQDKLRWQPFITHQSQLPQSTTNEKTEEDKENKSIAKDVNMIENDQGSDKQDEKLHENDEQNAGIIKNNNQDTQVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB59</accession>
    <name>I4YB59_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958873.1">
        <property type="nucleotide sequence ID" value="XM_006958811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB59"/>
    <dbReference type="GeneID" id="18471582"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32904"/>
    <dbReference type="HOGENOM" id="CLU_926100_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB59"/>
    <dbReference type="OrthoDB" id="3268823at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="301" mass="30998" checksum="772A517D3A147C51" modified="2012-09-05" version="1" fragment="single">MPGGFVGGIASAGTGVSLKDTSNQAKDAATRAYEAAATKVGDYTDGFSKSANDSAPNNLHEIAEKLKVDEKDPSNVVKNLADSTKPGVAGEYGHKAAAAVAGVAGAAGITGAAAAGVAASKKGEWKPKNYGDHVLSNPMDFPAGTFPTLETLAKDPESIPYIPGVSKERVEKASQEKKDDLNKQEESNKATKALAGVTAGVGGAGATSAVIADKYTPKTDKVAENTESSTTDNTQTIATNKTAHGVSPPDSSANIVKNSQDPKVTPKRSFSQRFKGDMKILFGKLSKNDTKISEGRELKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB71</accession>
    <name>I4YB71_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_32913</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958885.1">
        <property type="nucleotide sequence ID" value="XM_006958823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB71"/>
    <dbReference type="FunCoup" id="I4YB71">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB71"/>
    <dbReference type="GeneID" id="18471586"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32913"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119276_0_1_1"/>
    <dbReference type="InParanoid" id="I4YB71"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="117" mass="13613" checksum="E4B5D7FF1F88A7D0" modified="2012-09-05" version="1">MVRSKFKDEHPFEKRKAEAERIRQKYPDRIPVICEKGDKTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVNEELPPTAALMSAIYNEHKDEDGFLYVTYSGENTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBI4</accession>
    <name>I4YBI4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_18961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958576.1">
        <property type="nucleotide sequence ID" value="XM_006958514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBI4"/>
    <dbReference type="FunCoup" id="I4YBI4">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBI4"/>
    <dbReference type="GeneID" id="18470785"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18961"/>
    <dbReference type="eggNOG" id="KOG1004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069847_5_2_1"/>
    <dbReference type="InParanoid" id="I4YBI4"/>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="171" mass="18680" checksum="1D03294C66D77892" modified="2012-09-05" version="1" fragment="single">QYLARTGDSVIGQVIFRGSEGYRVDIGTATTANLDALAFEGATKRNKPNLKVGSLVYARISLAHKDMETELECLNPTTGKAEGYGELKGGILADNLDINKCKSLLEKNSPFMNTLMQGFGFPFELATAMNGKIWISAPSTSQTISVYRTIMKADKDGLESLNDEWFADIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBL3</accession>
    <name>I4YBL3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_54665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958703.1">
        <property type="nucleotide sequence ID" value="XM_006958641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBL3"/>
    <dbReference type="FunCoup" id="I4YBL3">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBL3"/>
    <dbReference type="GeneID" id="18472682"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54665"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="InParanoid" id="I4YBL3"/>
    <dbReference type="OMA" id="DFAIEFC"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="463" mass="52028" checksum="D16A08335F7F6FFE" modified="2012-09-05" version="1">MSNEEHFTKQKLWGGRFTGETDPLMHAYNQSLSYDKRMYAADVHGSKAYARALARIGVLTNEEADKIHSGLDAVKNEWETNTFKIHPQDEDIHTANERRLTEIIGSVAGKLHTGRSRNDQVVTDVRLWLLEQTALVEGYLKELIGVISNRADKEIDVLMPGYTHLQPAQPIRWSHWLCSHAFSFANDLERLRDLIPRLNKSPLGCGALAGHPFSIDRETLASDLGFKGVIENSMNGVADRDFIVEWLMWATLTLTHMSRFAEDLIIYSTSEFGFVTASDAYSTGSSIMPQKKNPDSLELLRGKSGRIFGQMTGFLMSLKGLPSTYNKDLQEDKEPLFDCVDSMKASLQIATGVISTLNIHPENMKKSLGMDMLATDLADYLVRKGVPFRETHHISGRCVAFAESKKIQLSEITLEQLQEIDSRFTEDVMKVWDFEASVDRRNAIGGTARSAVERQVKVLQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV0</accession>
    <name>I4YBV0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CNDP dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_64393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958472.1">
        <property type="nucleotide sequence ID" value="XM_006958410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV0"/>
    <dbReference type="FunCoup" id="I4YBV0">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBV0"/>
    <dbReference type="MEROPS" id="M20.005"/>
    <dbReference type="GeneID" id="18474922"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64393"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="InParanoid" id="I4YBV0"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="204"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="471" mass="52001" checksum="D419A7FF33F64A2D" modified="2012-09-05" version="1">MSTVSRYIEEHKDAFIKRLREAVEIPSVSGEIKRRDQVIRMGHWLKSQLEELNADVKLIDIGTQELEGETIPLPPVVFAQVGNDSNKKTLTIYGHYDVQPANTSDGWDSEPFELTIEGDLMRGRGSTDDKGPIVGWLNTLSAYKETKTPLPVNIKFVFEGMEESGSEGLDELVVKESQGFLKGTDAVCISDNYWLTNRKPALTYGLRGVSYFEICVSGPNADLHSGVFGGTVHEPMTDLIKVMGTLVNTDGKITIPGLYEMVQPLTDEELARYKNMDFDVKEYQDSIASKPITVSDDKATILMNRMRYPSLSLHGIEGAFYGGGAKTVIPAGVKGKFSIRTVPNMDIQKLEELVKKHLNSEFAKLNSRSNFEVVQLSAGPAWAADPNHWNFRAAAKAVKSVFGVEPDLTKEGGSIPVTLTFDESLKVNVCLLPMGRSDDGAHSTNEKLNISNFIEGTKVFAEYLENVATHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV3</accession>
    <name>I4YBV3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958475.1">
        <property type="nucleotide sequence ID" value="XM_006958413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV3"/>
    <dbReference type="STRING" id="671144.I4YBV3"/>
    <dbReference type="GeneID" id="18475510"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69017"/>
    <dbReference type="eggNOG" id="ENOG502RHQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1262395_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBV3"/>
    <dbReference type="OMA" id="REDPMHD"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="21724" checksum="CD0DD47C8692B2B7" modified="2012-09-05" version="1">MPLKLAHHKSYHPYNAANIERVRKDEEKAHLERELEVSINNSNESKNRLDKLRNKPTNPDNREHRSEHINFWSDLEKSANEKGKAKDEFPDMQLQRPSARWYDSQDDRAHARDAEPQRKRFRNDKDGDTKLKDTQDPLNIMKEATHELDKRSKVSKPIRNSHKMSKRERREEKERQRARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC04</accession>
    <name>I4YC04_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SURF6-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958525.1">
        <property type="nucleotide sequence ID" value="XM_006958463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC04"/>
    <dbReference type="STRING" id="671144.I4YC04"/>
    <dbReference type="GeneID" id="18473963"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60465"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847860_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC04"/>
    <dbReference type="OMA" id="RIETTQK"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37165" checksum="602505AFCD2CBC3B" modified="2012-09-05" version="1">MADLSEINNNFLELLSFIPENLYSHKEINLDEKYFKKSSNASKLQLKLNKQKSLREKLDPVVNGDAESDNLDTNASNIDDDGQSLQDLADSDSSSIQPMPSAGEHNKLKDKLHTRLLHMQRKRHGINPLDNTKDALLQSRRHQSINQPKKKVQLDKKPLYLDNKGKSTQSTSTEDKQQDSSLQFSHLQKINEIKQQKKQPSDPKQALQQLQAKKLKNKEKQSADNDNEDDNSDLWKSASAKASGIKVNDDEARLKKQIKRKDKVKAKSSKDWSERKKNLEKSMATAQKKKADNVANRKSKNKSAGPSKSKKRAGFEGKISNSKKPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC29</accession>
    <name>I4YC29_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_69084</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958548.1">
        <property type="nucleotide sequence ID" value="XM_006958486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC29"/>
    <dbReference type="FunCoup" id="I4YC29">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC29"/>
    <dbReference type="GeneID" id="18475523"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69084"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_2_1"/>
    <dbReference type="InParanoid" id="I4YC29"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="122"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="366"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="669"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="818"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="854"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM21521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="929" mass="103021" checksum="5E9863D0627490D0" modified="2012-09-05" version="1">MVVSAQLDFLNSDDEDNSIGNAVNNDEDVDISSALLPSSSKKNKEEDDDDQFIMDVMQTANKSKGKEVAKELNKGKGKGPKAKAQVGGGSFQSMGLNPSLLRSLFLRGFNQPTPIQRLAIPPILSTPPRDLVGMARTGSGKTLAYLIPLVQKLGAQHSIRFGARSLILVPSRELALQILRVGKELVKGYKKEMGEGQEEMRWSVIVGGESLDDQFSLIASNPDVIIATPGRLLHLAVEMNLDLKSVEYVVFDEADRLFEMGFQLQLNELISRLPTTRQTLLFSATLPKSLVEFAKAGLVDPKLVRLDAESKISEDLETAFFSVKPSDKDSALLALIKDVIKVPPGFQEAQDTSSKNDKEKKRKRTALPSFLKPYQTIIFTATKHHVEYLNTLLKAAGYAVAHVYGSLDQTARQLQMDQFRRGVSSILVVTDVAARGIDLPGCENVINYDFPTGARIFIHRVGRTARAGRKGTAWSFITNSELPYLLDLSLFLARPLVSPTSPTNKNKEEELASKNTLTIGTIPRDTLDPYVEYLSGAVLNEAPNLPSLHGVMMRGHGLYERSQGKASAESYRRAKDIIKDARWGFAGTSGEDKAMHPSFAGTAAETLQVDEETAKKRADLLAVVNGFRPNETVFEIGQRGNNDSAKLMKERRKDLAKAEHRLNLKEKEKALQEEMEGETTPGDSLDNADKEEQEQADEDDIAAVFDTGSKKKQKKDFRDPNFYMGYEHADAHTDKGYSLQDGATFAEQARTAEVTLMDDEQLKSQKMAPSQLKWDKKKKNFVRGGGIGADNQKLIKTESGARLPATFRSGKFDEWRKKHKMDLPRTGETEEKNHKALAMGMNGGVGGKKYRHNKVTEAKPLDKKDKNYEKKVKMRNKDNKDDSNAGKVRRGGNVANKKSEIKSVDAIRKQRELAAKRKAKNARPSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC80</accession>
    <name>I4YC80_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958269.1">
        <property type="nucleotide sequence ID" value="XM_006958207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC80"/>
    <dbReference type="GeneID" id="18475479"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68852"/>
    <dbReference type="HOGENOM" id="CLU_2335246_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC80"/>
    <dbReference type="OMA" id="IMLEDSY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="98" mass="10625" checksum="768AC012207BB7C6" modified="2012-09-05" version="1">MEIEELIINLKESHVGQNEIDLQAIKKQLIQTICPSNNNNNNNSNNNNNSSTPLSTPKLISSQLAGTVKNGERRTSIKPDDNNDGSGLLFNTTATTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCD5</accession>
    <name>I4YCD5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_54477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958322.1">
        <property type="nucleotide sequence ID" value="XM_006958260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCD5"/>
    <dbReference type="FunCoup" id="I4YCD5">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCD5"/>
    <dbReference type="GeneID" id="18472675"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54477"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="InParanoid" id="I4YCD5"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="167" mass="19316" checksum="9D0C9745A8BA5EA8" modified="2012-09-05" version="1">MNIRPATPYDLTGMQNANLMNLPENYQMKYYMYHALTWPQLSYVAEDHKGRIVGYILGKMNDEMDSKPGQLPNGHVTSISVLRSYRRLGLAQKLMKQSQTAMKDTFNAAYVSLHVRKTNRAAIGLYRDTLGFEVWEVERGYYADKEDALGMRLWLDQEAKAKQTKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCG8</accession>
    <name>I4YCG8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958350.1">
        <property type="nucleotide sequence ID" value="XM_006958288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCG8"/>
    <dbReference type="GeneID" id="18473915"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60364"/>
    <dbReference type="eggNOG" id="ENOG502SH2E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2980856_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCG8"/>
    <dbReference type="OrthoDB" id="3200438at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="58" mass="6765" checksum="7CCECB6BFCBFE2BD" modified="2012-09-05" version="1">MATETLHMHDTTMRDTTSLIDNDKRAKQQQRKVRFTMGPRADCLKCKLGIKGHYSHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCK3</accession>
    <name>I4YCK3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="3 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_68948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="3 8"/>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958381.1">
        <property type="nucleotide sequence ID" value="XM_006958319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCK3"/>
    <dbReference type="STRING" id="671144.I4YCK3"/>
    <dbReference type="GeneID" id="18475497"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68948"/>
    <dbReference type="eggNOG" id="KOG3261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091083_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCK3"/>
    <dbReference type="OMA" id="GWGTVYS"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="196" mass="22385" checksum="66E273A7146BCBC4" modified="2012-09-05" version="1">MTMKNIITVILEYAESAEYQSCYCEENIYRLVKKLADAGVQRNNRVAFISNTKKHVLLCQQNASSRGDPYPVIWDYHVIALFSLDDGDYVLDLDTRLGRLCRLDEYIQSTFHSSTSKELRAWLHVVDAETFIASFASDRRHMIVDGQYLSPPPSWAPIRGKMSNTEHNLEEFIEGSFQPASRVALDWSGSKTKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCR4</accession>
    <name>I4YCR4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-xylose and UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_18239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958030.1">
        <property type="nucleotide sequence ID" value="XM_006957968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCR4"/>
    <dbReference type="FunCoup" id="I4YCR4">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCR4"/>
    <dbReference type="GeneID" id="18470757"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18239"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033007_1_1_1"/>
    <dbReference type="InParanoid" id="I4YCR4"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="333" mass="37530" checksum="E80AFA45031632BA" modified="2012-09-05" version="1">MSRRNFWWIFILIDWITILSAIFGGCCSNAWSLESIMRKSPDCGILLTFAQFAAVTVYHLPHFLTLSSSWSLRFKARQVPLYDWAFIVSGFIAVNLLNNFAFKFKIPLPLHIVFRSSGLCVSMLLGFFVLRRRYTLTQIVCVAVVTAGTLITTAYSPQTGSEVASEHSPLDFDFSWDYVVGISMLALALILSGFMGINQEKLYAKYGSHTWPEMLFYSHSLAMPLIPFFLPNIIPQLRYFNKSTKVQLGESTIGIPEMHILLVANVFTQFLCITGVNKLTAKVSNLSVNLILTVRKAISLVFSIWWYGNSWNNEMTVGTLAVLVCLSLLNDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCT0</accession>
    <name>I4YCT0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958080.1">
        <property type="nucleotide sequence ID" value="XM_006958018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCT0"/>
    <dbReference type="GeneID" id="18474890"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64002"/>
    <dbReference type="HOGENOM" id="CLU_1653517_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCT0"/>
    <dbReference type="OMA" id="STHPLCR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="18110" checksum="05D18BA9E0C69795" modified="2012-09-05" version="1">MTIEVQKTADKNVKVDLLPFSIEYQGVADISTYFHPMGNTAAFRGRKITARDVSLGERVQGVCVSEIISDGHKSAKKPVKATKYSMDDEEDDDNEESNDDEPEEQPQQSQQSVSQVFQSTGHSFTDFRIWMPDDHVAETTHPLCRLEEQQKLFTLINTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD68</accession>
    <name>I4YD68_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958206.1">
        <property type="nucleotide sequence ID" value="XM_006958144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD68"/>
    <dbReference type="GeneID" id="18473871"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60299"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498945_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD68"/>
    <dbReference type="OMA" id="ESYPYNI"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62990" checksum="56ABF293019545AA" modified="2012-09-05" version="1">MFTRRALAITVILLGVFLFCTFTVLTALASYYAVPSDALLHPYPVDMPAFPQNPHQQPSDITNATWGEYDGFAYHVEPRRDKNETIPRILHWTWKDNNLPEMWRVVRDGCMDMHSDYEHILWTDAMSLEFLEKEYPWFVPTFKSYPYNIQRADSIRYFILYHYGGTYIDLDIGCRRRIDPLLQYPVVLAKTIPVGVSNDLMFSERKSSFMESVIHNLQTFNHKYFTHYPTVMFSTGPMFISTIYGFWMGNHPDVIHDRDAVRVIPKSLYGKNAKDGTVPDSFFDHYYGSSWHADDAGFITFLGRWGRGLLLIGGFVLFIGILRLVFFRRRGTSGLRQNHQFPPPAYFFPDSHFFDWRGQQIPLLPFTANQAGQGRPSSPSRSTPPSNLANSIPAILYYPFNPSTWASPTLPQTPLSNQNSINKAPSGISSWLSYILPKSWLTNDDDYDVVEQDESESEEVQSSPATPYSHHRSTTWARMEFQRARERELQRIKESHSTHNHAQSIDNYQPNNQSRNNSHQEEIEALLASLEPQLSQQHSTTNNSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDE7</accession>
    <name>I4YDE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_32195</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957799.1">
        <property type="nucleotide sequence ID" value="XM_006957737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDE7"/>
    <dbReference type="FunCoup" id="I4YDE7">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDE7"/>
    <dbReference type="GeneID" id="18471440"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32195"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDE7"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="359" mass="41424" checksum="4273BB5E52B1DB93" modified="2012-09-05" version="1">MDLRVGGKYRIGKKIGSGSFGDIYLGVNIISGEEVAIKLESIKAKHPQLEYEAKVYKTLAGGVGVPFVRWFGRECDYNAMVIDLLGPSLEDLFNFCNRRFSLKTVLLLADQLISRIEYIHSRNFIHRDIKPDNFLMGIAKRGNQVNIIDFGLAKKYRDPKTHLHIPYRENKNLTGTARYTSINTHLGVEQSRRDDLESLGYVFMYFLRGQLPWQGLKATTKKQKYDRIMEKKMVSSTEILCRGFPHEFAIYLNYTRSLRFDDKPDYSYLRRLFRDLFIRQGFQYDYVFDWSVQQRYDDRRKQAPEEGTQAATGGQTPGANAQAQVKQSDRVLRSSTRHAESGQQQPPQAGPSGSRQAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP0</accession>
    <name>I4YDP0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Scamp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_45216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957886.1">
        <property type="nucleotide sequence ID" value="XM_006957824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP0"/>
    <dbReference type="GeneID" id="18472359"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_45216"/>
    <dbReference type="eggNOG" id="KOG3088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066546_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDP0"/>
    <dbReference type="OMA" id="YPTGNQW"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="24126" checksum="9069F775D305606C" modified="2012-09-05" version="1">MDIQLRESRIKQFGRNNWPSFYPLIYLDIKEEIPAEHRSTTLLAYRLWLFLVAVFAINWVACLLLLIQGDGFESLAAASGYLLIIPLSFLLWFRPLYNALMKGHAFYYLVYLFFAGCHIVFSVYVFIGIPSTGGAGLINTIRAFTSGKIAAGVLCAVSTVGWAIQGLGFAWIYLQIYKLYKRKGLTIDAAKSEVTAHGFRAYFSVCSALLMMNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP6</accession>
    <name>I4YDP6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957892.1">
        <property type="nucleotide sequence ID" value="XM_006957830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP6"/>
    <dbReference type="FunCoup" id="I4YDP6">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDP6"/>
    <dbReference type="GeneID" id="18473782"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60163"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_1"/>
    <dbReference type="InParanoid" id="I4YDP6"/>
    <dbReference type="OMA" id="MRVAVCQ"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="291" mass="32199" checksum="03F08A0FAA2D5383" modified="2012-09-05" version="1">MTIAAVAQICSRQNVKDNALKCVSLIKRAADNGAKAIFLPEASDFIAQGDLYKTLSEPLSTSSFLNDIRAAAISSRIWVSLGLHEGGASDDRCFNTQVMIDDKGDILSSYRKTHLFDVKDVGPGNKPVLESMSTEPGKHIEEPIQTPVGMLGMLTCYDIRFPEVSLMLRSRGAQVLTYPSSFTVKTGKAHWETLLRARAIETQCYVIAAAQAGVHTTAGRTSYGRSMVVSPWGEIVTQLSTYDNIPSPFEKEQDMPDTSSEIAYFDIDLDYLNNVRASMPLWQQRRQDVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDX2</accession>
    <name>I4YDX2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_57209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957963.1">
        <property type="nucleotide sequence ID" value="XM_006957901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDX2"/>
    <dbReference type="GeneID" id="18472887"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57209"/>
    <dbReference type="HOGENOM" id="CLU_511114_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDX2"/>
    <dbReference type="OMA" id="HAYTHSW"/>
    <dbReference type="OrthoDB" id="10612243at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="533" mass="58284" checksum="B0A7E37E2C1B7A67" modified="2012-09-05" version="1">MSLASWLDDVNKRHANTVYASKEIDKEFQKIRRRRSKSLGSTTDIPPARSPKKTDLCLDIPQSNFNRRSNTARKWESSSGMATPTTPRKALAQTQPSTPTSSWTSNRVVGATLKGVNRAIPSPKERGIPLSPNSSSRRVEYPGFGESVKKLDFGGQRRRNSPIVNHYEKDVFGALLPGGNKENIPPGSEYPQLSPSLGASLGISVENNPEVSEKGPKMRPKEPNVLKRWQPINASANTPRERKISPSLRQLKTRSMPTFPPSVSSLRNTQSTNSSRSSLTLSTNDNIGRSPNGKLGDNSTTNTFTSFTSILNDIDHAHDNNKDINTSNKDTNKHKHHRSLSTPSIVVDNEAEGESEAGDISQSSLIELDVDHETVAPQFDLAATPRSDIFSNNIQLFPEVVAPKPIHVHIGNPLGRIEEEANVAHRPLPTQPINRSPNRHRPLPSPMLSPSMQPKSPLMTPPLSTPRHAALPAPPSGVDVFAEAANNNANALKPKRIYKPALNKNHSAPSFISQRKLNAPNVSYAATPPPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY5</accession>
    <name>I4YDY5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_68631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957974.1">
        <property type="nucleotide sequence ID" value="XM_006957912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY5"/>
    <dbReference type="FunCoup" id="I4YDY5">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDY5"/>
    <dbReference type="GeneID" id="18475442"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68631"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451442_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDY5"/>
    <dbReference type="OMA" id="ATHRIYQ"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="10">
        <location>
            <begin position="191"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="605" mass="68740" checksum="5FBADEDCFB1556E8" modified="2012-09-05" version="1">MNHTQFKYIDIKIRLQQSSKIFLDVLDNLDLNSCNAKVDPIDSLVIAYKHIENLYASKKSWTKNINFIIGDDLTTDNYEINNLSNLINQLHIGLNFIKMSDHENLFIDRLSPYIENTTTDTLDHQLDQLKKPHPSSSKSAAQSSRFNISDEISIKVKYQKAVGKATKLPLKSLRADNNSKVSTSQVHRLGDSKVDSHNLIRAYHYGSILVPRPDESEGGFVEFTSEAGIDFLSTFPASTFKRDMVIGEPSFIYADQSDGSSGLALSSFINALDKNGLIALVRYARTKDEKPYLGLCLPIINGQTEYLQYLRIPFADQMRNYSFPSLERVVTKSGEPLQNHKYLPTDKMCLAMDNFVNSMDLHDTDDKRTWFDINTSYTPAHHRIYQAVIHGASTGSIIKDELQDAHPELKKYLEPPSFAQKRSIDALENCKNEFNLTKPTPKAKYHRRHSKEDVREAQEINIDDLLGGKPTTSPRPVDKTIEGDAKKGTDGAFTPDQVWQTLNNLDDPEEVYEIMSASIRETLGKHTTDNHHPLKVGLQHLRDFATKNNIAEDYNELIREVKEDTQFWSFLRENEGEKLSLITSGEDEHGTSEVTSSQSRNFMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEB2</accession>
    <name>I4YEB2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957561.1">
        <property type="nucleotide sequence ID" value="XM_006957499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEB2"/>
    <dbReference type="GeneID" id="18471407"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32012"/>
    <dbReference type="eggNOG" id="ENOG502QWMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_1_0_1"/>
    <dbReference type="InParanoid" id="I4YEB2"/>
    <dbReference type="OMA" id="GWYKGRT"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="1">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="26438" checksum="A2B9315EFF499FAF" modified="2012-09-05" version="1">MRKRGSMSLFEKAPTTHFDKIQNTTCVLAPTVTEGPYWITGEQVRNDITEDQQGKPLVLDIGILDVNTCEPLEGAYIDVWHANATGYYSGFEDFTLDAPSKRQMNTPTSNNTYLRGIAKTNEEGIVEFKTIFGGFYTGRAPHFHLKAFIDAEESDDGSITGGETAFTGQLFFTDETANDVFAEYPYTENENTRSYNSDDTILTSEQGNGNNPIVDLVDIDGTFYGIITVGINATATDQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEK0</accession>
    <name>I4YEK0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957641.1">
        <property type="nucleotide sequence ID" value="XM_006957579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEK0"/>
    <dbReference type="GeneID" id="18474853"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63594"/>
    <dbReference type="HOGENOM" id="CLU_088686_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEK0"/>
    <dbReference type="OMA" id="FKENIVM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="213" mass="23997" checksum="7EC13BC7F1CE1B6F" modified="2012-09-05" version="1">MAATLEISHQTRDGDIARLSITITHDSGYVDTMESIALHSDENAKVTMRLTFKDNIVMVKHPDGRFQITFTTNSSAIEFVDRARKFKIECVAANETIPLLRDGMRRTESSSSKLGSQSSCYSMPPPATQIQTQFSQSYKLSQQATPPASQKRKRGDEISLREADSTDNIDIDINNDKLLTESIMRVIHEPDFVKLVDRLRSVDALRLTPRSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YES8</accession>
    <name>I4YES8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conjugated polyketone reductase C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_32151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957710.1">
        <property type="nucleotide sequence ID" value="XM_006957648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YES8"/>
    <dbReference type="GeneID" id="18471430"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32151"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="InParanoid" id="I4YES8"/>
    <dbReference type="OMA" id="PWMREHG"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="279" mass="31092" checksum="28FB425862A11C26" modified="2012-09-05" version="1">MSEISLKYNGTIPFIAFGTGTSLFKQSAYDGVRQALNKGVRHIDTAQIYGNEDSVGQALKDSGVSRSELFIATKYGGGRDVRSEFNDSLRKLQLEYLDLYIVHWPKVVEQSGGLAATWSEFEKLKSEGLVKHIGVSNFDNNDLDELLKTAKEYPEVNQIELGPTCWKKVEHIYKRNAELGIVVEAYGALAALTSPKSDLDNLFSQLGEKYGLSKGAIILLWLKSHKIVAVTTTSKDERFEEYNKVYASTLEEVDGEAISKLGKQYLDVKFPEHLSNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEU0</accession>
    <name>I4YEU0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957722.1">
        <property type="nucleotide sequence ID" value="XM_006957660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEU0"/>
    <dbReference type="FunCoup" id="I4YEU0">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEU0"/>
    <dbReference type="GeneID" id="18473735"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60090"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047332_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEU0"/>
    <dbReference type="OMA" id="RQKEMGG"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="178" mass="20053" checksum="A039903513478491" modified="2012-09-05" version="1">MADEPDTYDAQKEAAEQATLPYKWSQTISDLDITVDLPAGIRARDLSIIIKRRKLSIAIKGSEAIVDGTLFADIKEEDSTWSVSDGMLNVHFEKVSQAAWWPCVVEGAPRIDTKRIVPENSKLSDLDGETRAMVEKMMFDNRQKEMGQPTSDQLKQQEMLSKIQSANPDMDFSKVQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF14</accession>
    <name>I4YF14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_68021</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957226.1">
        <property type="nucleotide sequence ID" value="XM_006957164.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF14"/>
    <dbReference type="GeneID" id="18475332"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68021"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254365_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF14"/>
    <dbReference type="OMA" id="RPWEWTE"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SRB8 ARM-like" evidence="14">
        <location>
            <begin position="610"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1367"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1400" mass="159423" checksum="826325AFB71A13F8" modified="2012-09-05" version="1">MNKLEIYDLKPLNWRLPISSNSLEYPDFYQPIRGRDEDIINQNTVQNGYTAPPAVQNETFSCNQLIIDSLQSNQVASNLELIFKSALDKRHTRNHPQSNYIKDLDAADANLYFKQLACTNIPLQNLLKLPRNLTPSVILHQLQLNQVDPRRSIWFIKLISKPSSENKQLSFNLSMDWTRVLTGQLSDKLIELPTPEGVLDNFDSKLWLSQFTYILDILRAFIVNGLLDNLTLHIWLLDHLKHIHMARLPLVTTLVLENMQGFYSSHQLTNGLVDAACCRLGQFKRTIAGENLTSLRSSLERIIINVFTCFPCSFVSPKLWISHGSLFESLIGTQPHYQAIQKRNHQMLYGNTDKSLSSTPYSSRQSLVRDITLLDTINTNTNIRACTLSYFQVDDKLPKRTIDEKITTMLDWASTENRNSQHRCYAVATILRFYISLQLKQKLSSKNVIKRHLQELIFSWIEVTSSDRKQEDVPKLIGELVRRRVFSYSSYLQHIIATGLMSNTKKSAIHKNILRDTPLFDASLSIVNLRRMSIDKQLNADDEKSLDSLIRTFRALLPRLYKNTENIPLITTLDLDNSFRAFKKLPLFYRYRCIQSNLLPSVYAFIDTKTSESKMSIDEVATVISILEYFEDFASLQSLLMELIPKISERQVLFLLMDTIRRNWTTLVCLNGMDKLIKCVTDKYYAFNSSGGHVRPLLLLLVTAKNTSQLPHQLLPFVNDAAAALNRSLRTSMSPSPPPSRISDVQKLLYDSTISNAADLATTLWFRHSSYTQWGSSAWMGVLDALKVKHDNTPQLVSCFSTFLHEVNNRFPDGLEKHITESLVKHPETLLSGELSEVMKSILVQMVVRRVVQTTSIIEDVYLPLISQSPSDEVVLNLNDVLLSILTPEKKSPMILRDYQHLMTRRGKAYRPPYLGKLAEILPVLVNYEVSDNVSETVKSSCRFLRESISSQSAFSTACMRDLDNVYEVMMSASKTNIQELIIDTLKQLISFSNDDVEHDDKFAIHHANPWTISRHKIVLHLVLNYNSCENKRCHTTVSDLLSQMDNNTLVLDMLRGISGNAGQEFANIKFSSIMTLLASLKDLIDGDKVDDELRCSSEIYGNVEMVSQVLLHKKVTLPLIDSDIITQMIKNLNLCFQSIFLPGDETLENGEVVEENEDTKMTESISHSRTLEVLCMLIQVLLRVPESLTASISDIGNRILPHLLRQLTRSDDGQFEKLYDTIIALVERIPGNSTQDAFNVVDPSGTDLPIEIRRVLPLTQSMRIQTKFSSWDLLDQIPETNDSKRVQFNAPQLHKWLDAQLVNDRLLDANSQIEFEYERNIPGDGLEAGPILAYQFKRSLRNQDLGMTTEPPVDDVGINLKKRKVDEENGSNGNGIALTPASNLSTTTQNRRTSTRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF23</accession>
    <name>I4YF23_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUC173-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_44179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957235.1">
        <property type="nucleotide sequence ID" value="XM_006957173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF23"/>
    <dbReference type="FunCoup" id="I4YF23">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF23"/>
    <dbReference type="GeneID" id="18472323"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_44179"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="InParanoid" id="I4YF23"/>
    <dbReference type="OMA" id="PDQMKHR"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="317"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139258" checksum="63819E264953C46D" modified="2012-09-05" version="1" fragment="single">MDAELLKIRPHINSKLENQRQPALLLAAIEETIKEQSESPSAVSYHSLLLSTLEEAVTNKKLDIAASALYLEAIVVKFVNKNILHNQYQILESLLNLLATYNSNTPALKSLLVVLEEYYTALDNQQLQLQSFKSSFNDLLQLTIDNRPKVRKLAQSTVINILTIDHPYLNSTTNWVIKSFDQLVKRNTPTEAGIHLCALVQALDSIWPIQTLPKLATSLLNTPHLGNSYLTSSSYHLLSHLLSNKQSHTTFEEDKLKSLVETIATSFPKPDDVLLLSPWLAILDAAISSYARHDPEAASLLILNVWPKVYGDYGLASTHTDVRKSAEKALCGIIRWGVTTDMIKNTVEKNGRVNLQPILDNILSSLTGIAHRQALPNVITVLVAMISKLRVRFNTPGSTAAEALVAPHLTTVAELRQMPNFEFREKTDDVFGMALEVCGPSWVLSLLPLNLDPSKQAKGKDGRAYLLPIMRSRVSNTQLNFFVKELVPLSSSMFDASSKAQEQGKALEAKLYSTLMEQLWATFPAFCDLPIDLRDALTGDFAGMLSNVLYSQPVLRPSVLRGLRNLVEKNLTLCRSAGPVDEIRKTFNGLDQNEAKLNVEYLTTIAANLLSVLFDLFGTVNRDSRGMIGEVIADYLVIASEKDVSGTYKKLSKMLLETLPQHNVKMAKQAKSNKTFNSSADNTVAPHTTMDLLILLAPRLATKQAINAWEMGTSDQVLMSEDQAVQKKAYRLLNRLCESQKELFGDQKRIEKTISILTNTDNISGGVKRDRLELFSVLVKFIPTDKLHYIVSLVPEAVLGVKETNERARSAAFELLLALGRRMETGGKVERAKVGQDDDDDDEEMQTEMEVVDANINEYFTILSAGLAGSTPHFISATITSLARVLFEFRESIDKGLVDSLLGTLHIFVGSTNKEIVKAAIGLVKVTTTSLPSDIVFTHLESLIPSLLGWKNEHKNHFKVNVRHILERLVKKFGFENVEKFVPEADKKLITNIRKRTQRAKKGRAGKEDPIDPLDEDDDEKKTAKKGNDAFEDALYGSESEIEASDNEEENTKKGTSKRGKKQQEDTYIREDEGELVDLLDKSVVGRLSTYDPSKVKRKLPGQDAQKYKTDDVTGKLIIEDEDVAIDQNQDEGDKLAGEAYLENLEGEDGITMGKDGRVRFNKKRDRGQDVEMQEAGAGSDDDNSSKKKKKNRQGTVGVGKEFKSKRAGGDVTAKGGQQPYAYVPLNQTKKLNRGGQAPRLDVTGKKKGRSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF52</accession>
    <name>I4YF52_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_31809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957263.1">
        <property type="nucleotide sequence ID" value="XM_006957201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF52"/>
    <dbReference type="FunCoup" id="I4YF52">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF52"/>
    <dbReference type="GeneID" id="18471370"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31809"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="InParanoid" id="I4YF52"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="86" mass="9479" checksum="2FAB965E9097CEAE" modified="2012-09-05" version="1">MENDKGELVDLYVPRKCHATGRLITPKDHTSVQLSVAQVDANGKMTDGREFIALSGDVRAMGEADDSINRLATERGLLRNVFTYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF59</accession>
    <name>I4YF59_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_27860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957270.1">
        <property type="nucleotide sequence ID" value="XM_006957208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF59"/>
    <dbReference type="GeneID" id="18471014"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27860"/>
    <dbReference type="HOGENOM" id="CLU_2005680_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF59"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="124" mass="13385" checksum="471F4E8BA8039523" modified="2012-09-05" version="1">MSEFTDKLYLQAVAWVVRRNKKAGAWQQTDPGQEGSPTWGYKEEPSSTHLTADADASTGVGMAALRGNTREDDEPRPSFQSYENNAPGVTVSDLLSNGQGYGVVPQHVVCANSLLLKESTLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF77</accession>
    <name>I4YF77_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_59855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957285.1">
        <property type="nucleotide sequence ID" value="XM_006957223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF77"/>
    <dbReference type="STRING" id="671144.I4YF77"/>
    <dbReference type="GeneID" id="18473589"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59855"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="InParanoid" id="I4YF77"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="117"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="294" mass="32909" checksum="FB9665F695723BE2" modified="2012-09-05" version="1">MTSALHFGNPEHLLPPSWRSQVQQWLSEDTPSFDWAGFVVGEEYRDAKLLGKRKGVLAGKPFVDEIFKQLNCTIEWHVKEGESFEPIKHIATVRGAVRYLLLGERVALNVLSRCSGIASMSRWFLDTSRDAGFKGIIAGTRKTTPGFRLVEKYGMIVGGIDAHRNDLSSMVMLKDNHIWSKGSITNAIQAVRSVAGFSLRLDVEVRDEKEANEAIDAGADVIMLDNLDGEELHLVSKRLKEKWTGKRHFLLETSGGIEAHNLTERLGDNIDILSTSAVHQNVQHIDYSMKISRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFG4</accession>
    <name>I4YFG4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957368.1">
        <property type="nucleotide sequence ID" value="XM_006957306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFG4"/>
    <dbReference type="STRING" id="671144.I4YFG4"/>
    <dbReference type="GeneID" id="18473616"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59900"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535515_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFG4"/>
    <dbReference type="OMA" id="ELVDIMP"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF38">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="329"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="509" mass="55670" checksum="D781C8C7A8807135" modified="2012-09-05" version="1">MRDIDRNKEITVDDKPIDISDLNLKHFETEYYNGQQQQHIDAANQTIQQQQPSYLPTIDNYYNPQYTQPSEQDDIDLLLTPFLSPAQTPQSAFSQPRPTPSLTDDSASITQAEFFSPLTSPALHPVVPEYYSPRLGPQLSSSATNSPNTFQRPGSHASRRGATAEAKANKVRPSPVMKPVSSKLRKSSIKQDDNAAGSSDNSLSPINLDLDTAAMPPPPPPAASTSQQSADLAPITPATLMNLNNNNSTTSSSMSVNSSGTATPSNFNENYVQASPSLTPIIPGMNMTPRDFASMSLQNDANYANILTGRSTNPKHIELAQSEIQDNGSKRMSHKLAEQRRRDSLKHSFDDLRGLLPPVVDDDDTGGLSEGRLDLRLEMKDIDSAQINKGVSKVVLLKLANDYISILNHRISRRDNVIAGLRKQLAESRGEQSSDAEMKDFLNQIDGVEHELQQAALQAMGGEGEQRRKSVSESGNNKSGVGRGKGRIRGANKAAKQYLQQATQETHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFL4</accession>
    <name>I4YFL4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_27987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957413.1">
        <property type="nucleotide sequence ID" value="XM_006957351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFL4"/>
    <dbReference type="STRING" id="671144.I4YFL4"/>
    <dbReference type="GeneID" id="18471018"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27987"/>
    <dbReference type="HOGENOM" id="CLU_1455464_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFL4"/>
    <dbReference type="OMA" id="KFTQGET"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="186" mass="19983" checksum="E36D11AB98228773" modified="2012-09-05" version="1">MDFMNLAKKGMDAYQQSQGGNDHSEQSSNDHGLDFSSILGMAKTEHNDEGSHSMIESAISKLSSNSHELQDGVDEEETKNAHNKVFSGDKENASPKEHGIAYAYDLYQKHFAGGQNQTNEKDSDLFGKVIAEASKLADKNLGGKSSDDKQSVIDSATMTFGKLMIKQKLSGGSSGGLSSLAGQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU0</accession>
    <name>I4YFU0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_43646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956884.1">
        <property type="nucleotide sequence ID" value="XM_006956822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU0"/>
    <dbReference type="FunCoup" id="I4YFU0">
        <property type="interactions" value="812"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFU0"/>
    <dbReference type="GeneID" id="18472299"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43646"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="InParanoid" id="I4YFU0"/>
    <dbReference type="OMA" id="NNRYARA"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="846" mass="95164" checksum="ADBC65919D5D8F7E" modified="2012-09-05" version="1">MDFELALLEGEGGTGLVELVNQGKFKDVLLSDPAQKLLGDIDLDYLKVRINISEKDALSVAVALLHSFIQINWTGPDLDFNLTDLNGLWSDYDYHNSIAIQKLSTGGEPAYHLTRFAPLLLIAQAIFNELVKSDEGELPLGSAKWWNLRAAVAQQHLLDECVPLPESMLDGVKKALIDKLPPTLKARLTLEVGIAYHMFERDREASETFLEAANTNELKFHLTGALGKRTKFQQSDITQLVLLAESRDSQESKENADSQVKDLELNDDTLLEQTQFSSTVDSSAPLSHIDPSNQPKLSAIDQCILLGMCLNIKNTAPENGLTNSQMGAFVQRVLSNHQNWSIYTMSLLLRSRLEAHRTRTVQRATLQLQALIDQMPTSDSSNVERLKYFFAMPMPAKWELERELAQRFVNIGVVRSALEIYQKLEMWEDTIICYVSTDRQNDALDTVKGLLEGSIVESQTITSRAKATVDTKTRTRMDVMRVAKLWCLYGDLDVPNCEQHYKKALEVSNNSSSRAYRSLGGLYFAKGDSKSTIEVLRKAVAINPLYHHTWFILGCACIRLEDWDGAIEAFSRCVAIEDDDAESWNNLASVYLRLGDKAVTHESKMHAFRALKQGSRYGFDNWRIWQNLMIVSIDVGELADATRAVGRLADIRGELICGENDDSSELDVVDKVVDAVTLAPRNERDAIEGDTSAEGAQVVHNSNEGHGLLRAVDRLFDYSLLKKVSSPRIFKSYARLNFWKGQYRNAIDMHLKAYRASVGSDDTVENDKKAFQKASETIIDLVDVLQNFGEKPADVNDPNNQEDASPDWKYQARSLLRTFLGRTRSTFEDEKEYAQLKELLEEIRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFY3</accession>
    <name>I4YFY3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-3'-phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_36105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956924.1">
        <property type="nucleotide sequence ID" value="XM_006956862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFY3"/>
    <dbReference type="FunCoup" id="I4YFY3">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFY3"/>
    <dbReference type="GeneID" id="18471945"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36105"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFY3"/>
    <dbReference type="OMA" id="YTDQNKG"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="7">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="357" mass="39178" checksum="D4755320C97E0E8F" modified="2012-09-05" version="1">MSKSLIRFTGHTFFRQRLVLSTLIGRPIRIDAIRAEDDNPGIRDYEAGFLRLLEKITNGSSVEISYTGTSILYQPGSLVGGKVTHDCSTSKSIGWYLESIMVLAPFLKKPLNLTLKGITTDGVDISADTLRTVTLPHLTLFGISEGLELKITKRGAAPLGGGEVSFSCPTLRQIKTLNFSDKGRIKRIRGIAHSVRVSPQLSNRMVEASRSILNRYIPDIYLYTDVYRGEEAGKSPGYALTLVAESTTGTLHTAEAVSEPGTTPEDIAKKAAFGLLEEISHKGAVDRSHQWLVLLLMSLGSEDVSKCRMGELTPHTIQFMRDLRDVLGVTFKIKPLNDDEYMLSCVGIGYTGQKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFY6</accession>
    <name>I4YFY6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_59662</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22878.1"/>
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    <sequence length="1135" mass="130108" checksum="07045C1F4A709E56" modified="2012-09-05" version="1">MKFNQLVSFFDNISTEKDTLKRSRKLEKLFDYHRKQFGNDFYNLLRLMIPERERERSMFGIKEAVLAKIYVELLALSKDHKDGHRLLSWKAPTAGNFVSGDFASVLVDVMKNRVSYERKSEFTIDEVNDKLDQLSRAKNFIQKKDIMKEFARNCDTTEQFWLVRILLKNLKISIRERSILSHFHRDAYSLFEVTTDLRTVAYKLYDPSIRLHDNDSSVQLFQVFQPMLCKRNVIPQIIKKMPKSVPFVVEEKMDGERIQLHKKGTKYKYWSRNAKDYTYLYGENPKEGSFTPHIHHSFDDRVDEIVLDGEMLAYSAAVDTILPFGTLKKAAKGDINIHPVFIVFDVLWVNGKDISKYPFKERQKVGKTVFNPISTRIEHVSRWEATQADELKQSLERIIISKGEGLVVKSPLSLYEYGGRSDQWIKLKPDYFDEMSETADLLVIGGNWSASRNGTISTLYCALVDDRHETDEPDFLTFTRVGTGYTAMDLELINQHFRKSETRKYTPASVYPGIEIGNETPDIIIDPKDSFVVEIKASDINRSVNYPCGYTYRFPRFKRLRLDKGNGRENPVDPDNMFKYSDMIAMRDGIQSSRRKQTEDKIREKKRAQPTKKKKQVISSRAVANVRAEKDNVRSNLFEGCAFRILNGTNDLEVSDLAVLVSERKGMILSKIPNDEDCPEPLLVVAGKPTAVQVTQLMKTQKRSILSANWLLDCVKHNCIIPLEGKDGESQWVFECATDRDTILNTLRPFFVTPEGRNLPGVSQGQIDEDAVGEINELKFAEEPTLHSEADSAQDKDFDSDTATENERNESDNDIDIDDTIQEEAAEEMANTKADVSSPLQQTQPEYKQTSTTRTATRRKANKTDEFDSSDESDDNKSIPTATQKQASPEHVKESQKISTPSFIKQEVKEENVDENATSHNEKNLATSSPTTKRQLHETRVVSKDEKRRSHDNAFDSGSDSDAHHEDGPVKKVKHEAEPHELKGQDAEVESIKHYEKSSQEQSQDLDNTHTSVPIEEVSIEGSDKPENPLLNVVVYIDDYENAIENDLFPRPSITTEIDWSVVKDRITNLGGKIGELDDDMLTHIVIDSRDKARVEELFDRTKQPRYRKLVSIDWVNSCYENKSFVDESLYKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG68</accession>
    <name>I4YG68_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_59704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EIM22960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG68"/>
    <dbReference type="STRING" id="671144.I4YG68"/>
    <dbReference type="GeneID" id="18473508"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59704"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292078_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG68"/>
    <dbReference type="OMA" id="QCHARWN"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="437"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="957" mass="108644" checksum="4D79F9DEBE30BB03" modified="2012-09-05" version="1">MAHALDEFSYKQFIPEYEISNLKLKVNQRITRPFIPMMSKLRRSSAKIGSTGLGWKNISIKLSSTGVLFLYTEENALINSVPLTNLRMTDIRPVDNSVYSVPNMIVIHTHSLSPTLLIGQNSSGHSSSSYSTLGLLNNLRPTSPKSSQRLSPSVNQFSNANTDEPIFIAFPSRRHMVAYLTLLRSCTKADVYHTSKNPHTGYFRISRQLSINVMELRPPQKDLLSLNQSGNPDDTSNGTLNSHNVNSINSLSSTSSSGLSPSLQRRSSTHFTESCDTYEWYCEIWDPTGLAFKTSIKVGQHPFWKEDCLLLDLPNLNSVTIKIFRSLSSHTLSKGQSTLFGTVFIPLKAYPRLSEVEKWFNVIGVNDTTLETSIRGELRLSLRVDEDVILPQSRYSELFDIIRGQNRVKVIHDLSSIYPSLEHLADTLISIYSVDSELLVSVINDLAYKEIWSSRADENTIFRPNTILTKLMDRYMNFMSRLTGWLEDSLGEPIREMIEKKVECELDTDRKRGPADKDELLYWADLVLNSIIESRVGCPIELRRIFHNIRKQCHARWGKAQLVNSFIFLRLFVPAIINPNLFGLTNIAPTPPVSRTLTLIAKIIQALANNKEELGDKEHFMGVVSPFLQDRNRRFAFIDYVAYVGNEDSAASYETSEEISINELAKSVERTSDERFSNYKHDIYRESLPNSFNGIDYSRGLASFTNDLTNLYNKLQMNDLQNRDHHIKRKSLDHTTLELFDASLEIQDEARILWETRQKHKRKANSAYEASKANKSEWLSDQQDGRTMRKASLSSSGTATSGMDAQSRNSSSHRRRGFTITGLSAAGNNNNSNSNNTQTNNNLTPNHQKFMTLSRGASDYYARQFEVERRASSPNTQETFKDVRATLSKYNISNDVVPENSSPHNHQIPVNSFYESRSKSRASVRNSIVKGDQGQGHSKDDNYVDNRKKSSFFKWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG69</accession>
    <name>I4YG69_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_59705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957006.1">
        <property type="nucleotide sequence ID" value="XM_006956944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG69"/>
    <dbReference type="FunCoup" id="I4YG69">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG69"/>
    <dbReference type="GeneID" id="18473509"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59705"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099086_0_1_1"/>
    <dbReference type="InParanoid" id="I4YG69"/>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="15574" checksum="B64AA4A4C9C56EE6" modified="2012-09-05" version="1">MFGIIRSAVQARALSRVQSFKPTLLQVRNYSAGHEEESFEDFTKRYVSFFDQVEDLFELQRGLNNCFAYDLVPAPEICESAIRASRRVNDFSTAVRIFEGIKEKVENQGQYEQYLDALKPLREELGIPTKEELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG81</accession>
    <name>I4YG81_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_62994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957015.1">
        <property type="nucleotide sequence ID" value="XM_006956953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG81"/>
    <dbReference type="STRING" id="671144.I4YG81"/>
    <dbReference type="GeneID" id="18474804"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62994"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="I4YG81"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="384" mass="43223" checksum="DFBC2CE19FD4DC94" modified="2012-09-05" version="1">MGFLRDTLLSQPESYHKKKNYLFGEVLGEGAFGKVIRAEWQCHPAGKQDVAMKVISKKKAQGNEKAIFDEMDVLKNLDHPNIVKFYEWFESRDNYYLSFELATGGELFDRIARKGRFSEKDAATVIKSAVDAIAYMHSNGIVHRDIKPENILYKTKDDSQIVIADFGISQRLDNDNAQITSLAGSVGYAAPEILNSQAHSKPVDIWAIGVVTYVLLCGYSPFRSEELKELIEETNRGKIEFHDRYWSKVSDHAKDFVKALLQPDPSKRPTAAELLNHQWFKDQNLSDQDVGQGLRDAFNSREKWRSAIKAVTAVSRFGKLGQEAANARSNTPKDDGYENFKKFDFNSNRSLGSSVAANAANSRPANEVDESNVSEYESANEEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGG7</accession>
    <name>I4YGG7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_31689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957093.1">
        <property type="nucleotide sequence ID" value="XM_006957031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGG7"/>
    <dbReference type="FunCoup" id="I4YGG7">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGG7"/>
    <dbReference type="GeneID" id="18471355"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31689"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034979_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGG7"/>
    <dbReference type="OMA" id="YVLESVN"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="207" mass="23645" checksum="0DDF207A25F8FDB7" modified="2012-09-05" version="1">MSSTSSSLRTLLVIAHPDDEVMFFGPTLNHFRRKGENLHVLCLSSGNADGLGNIREQELYSSLSVLGVQPDNVNLIENAHLQDGMDKSWPEELIANVVVDYAKVHNIDRILTFDKEGVSSHPNHKSIHWGTKRVDLEKCTLRTHSIPMKYSMFSIPPEKSSLTIFSSFGDYIRSIGGMMRHKSQLVWFRVLYILTSRYMWINEFDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGT6</accession>
    <name>I4YGT6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_35576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956572.1">
        <property type="nucleotide sequence ID" value="XM_006956510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGT6"/>
    <dbReference type="FunCoup" id="I4YGT6">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGT6"/>
    <dbReference type="GeneID" id="18471917"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35576"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="InParanoid" id="I4YGT6"/>
    <dbReference type="OMA" id="FHAHTIN"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="119"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="331"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="413" mass="46472" checksum="962058DD5E202309" modified="2012-09-05" version="1">MKPRLNFKGVKNEIEYFKKNNINRNIKLDLNSFLSIYNKSTTLENELNKTKNEQTKQQTKELKLVIKELEKNLKFAKDELFDLTSQIPNKSHPKSPINNEPNEILSGGPTATPSTPLRDHLNIANRLNAIENASDISGNGFTILKDELAVLEHALIQFSLNIAVENGYKLITIPDIVKLDIANRCGFLPRDNSSNQTYSITNSSDNPLCLAGTAEIPLAGLHYNQLLNQSSLPLKYVACGHAFRAEAGARGRDTRGLYRLHQFTKVELFSLTDEKSSDSMLEEIINVQKQVVEALNLPYRILDMPTQELGASAYRKYDIEAWMPGRGEWGEISSASNCIDYQSRRLLIRYKDTQSGGNIFAHTLNGTAAAIPRLILALIENGAESDEDANIRLALPKALQKYWIGKEDRIRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGW8</accession>
    <name>I4YGW8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956602.1">
        <property type="nucleotide sequence ID" value="XM_006956540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGW8"/>
    <dbReference type="FunCoup" id="I4YGW8">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGW8"/>
    <dbReference type="GeneID" id="18473388"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59493"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_3_1"/>
    <dbReference type="InParanoid" id="I4YGW8"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="313"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="542"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="606" mass="68575" checksum="C8CE19C6EA241724" modified="2012-09-05" version="1">MMNRLQLLRRTYNQYQINAFFVPSEDAHMSEYIADTDKRREWISNFSGSAGHALITEKEALLSTDGRYYLQASQELDNANWKLLKAGQPNVPSWYEYILQNYQAPFKVGIDPKLIAFSEVRKIQDKLKSKSGFDLVPLSNNPIDDIADLPPYPDNEVYVQPMKFAGKTVTQKLSELRNYLTEKDCHSFIVTMLDETAWLFNLRGTDIVYNPLFFSYAVVTQESTTLFVNSARMTSEAHKEMENANVNLKPYEEFYPSLKQLSLDAENENKKILVSDKANWEVVRSIGEKQIDVVRSPIGDAKAIKNEVELQGTREAHARDGIALTQYFGWLEETLKENKAPLKEYDAALKLEEYRSKLDNFKGLSFNTISATGANGAIIHYSPSTTDSSVIDIEKVYLCDSGAQFLDGTTDVTRTYFFGSQPPSDKLKRAFTRVLQGHIALATAVIPTDKVPGPFIDSFARLPLWKEGLEYNHGTGHGIGSHIGAHEGPHTISPRWNDVTLKNGYLVSNEPGYYEEGQFGIRTETIVAIVPHKTPYNYNGTQFSTFETLTMCPLGTNLIEAELLSQSEKDWLNTYHERCVSVLKPELEKRGDTRAIAWLEKNSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGX1</accession>
    <name>I4YGX1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_31367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956605.1">
        <property type="nucleotide sequence ID" value="XM_006956543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGX1"/>
    <dbReference type="GeneID" id="18471289"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31367"/>
    <dbReference type="HOGENOM" id="CLU_1469332_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGX1"/>
    <dbReference type="OMA" id="ANNTCTH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="20899" checksum="3948E55C69E97EEB" modified="2012-09-05" version="1">MSIDEISYADTLYALVIQPLRQYFISLWNFITWTPKVNDNTSNQLDESTEPLLGNQSDCDDHDISPPSENKPVVKTAEQRRLEQFEAYLAEKKRRKAAKKFRRMLETTTTLSESGNERKHSKNIRGPPTDVGSIASSSFSGMSASTISPHEADYNSAFSLTQDDLLFLKQHDQSDLVRTTKEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH07</accession>
    <name>I4YH07_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_59516</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956640.1">
        <property type="nucleotide sequence ID" value="XM_006956578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH07"/>
    <dbReference type="FunCoup" id="I4YH07">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH07"/>
    <dbReference type="GeneID" id="18473400"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59516"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="InParanoid" id="I4YH07"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM23249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="358" mass="41559" checksum="16DA13D2CAA1518E" modified="2012-09-05" version="1">MAEIRQRKLKIYTRADVQTHNKPDSCWVVIGRMIYDVTEFLQDHPGGDDLILKYAGQDIEGAMKATNGIEDHPHTPAAFGMMSEMIVGKLDSGARIVDENWVATDDFVPEESNIQEDLERCEFLDLSKPLLRQVWESNFSKDFYLEQVHQPRHLKKSARLFGYDFLEMFTVTPWYVIPIIWVPITLYLLTRSYMEFSTKFGGALGGLSTLGCFLTGNVIWTILEYGMHRFLFHVDDYLPDRPFFLMLHFLLHGIHHYLPADGLRLVMPPILFTVLQYPFTQLAYKIFPGTAIANGIISGSFAFYVLYDCMHYALHHTKLPNYLKQMKSYHLKHHYSNFELGFGVTSKFWDLVFKTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH50</accession>
    <name>I4YH50_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP synthase subunit J, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_53600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956680.1">
        <property type="nucleotide sequence ID" value="XM_006956618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH50"/>
    <dbReference type="FunCoup" id="I4YH50">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH50"/>
    <dbReference type="GeneID" id="18472621"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53600"/>
    <dbReference type="eggNOG" id="ENOG502SC94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174950_1_0_1"/>
    <dbReference type="InParanoid" id="I4YH50"/>
    <dbReference type="OMA" id="KPMWPFY"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="59" mass="6517" checksum="7882BB96997E4B2E" modified="2012-09-05" version="1">MFFGLRKYPTPVLKPLAPFIAGSIVVYYGVSKIQDAAVATEPHKSSPQNPYISQVNNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP7</accession>
    <name>I4YHP7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_62160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956167.1">
        <property type="nucleotide sequence ID" value="XM_006956105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP7"/>
    <dbReference type="FunCoup" id="I4YHP7">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP7"/>
    <dbReference type="GeneID" id="18474715"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62160"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_1_1"/>
    <dbReference type="InParanoid" id="I4YHP7"/>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_uS12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="163" mass="18167" checksum="426C446AA5719293" modified="2012-09-05" version="1">MSVMNSFLRSFTRLNLRTQYQQPSTVFTRRSISSTPTNFATLNQIMRGARKSFTKVSKAPALENNPQKKGVCTKVYTTKPKKPNSAIRKVARVKLSNGRVVRAYIPGEGHNLQEHSVVLLRGGRTQDLPGVRYKIIRGALDFSGVVGRSSARSKYGSKKPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW2</accession>
    <name>I4YHW2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_53349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956230.1">
        <property type="nucleotide sequence ID" value="XM_006956168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW2"/>
    <dbReference type="FunCoup" id="I4YHW2">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHW2"/>
    <dbReference type="GeneID" id="18472611"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53349"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="InParanoid" id="I4YHW2"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="35997" checksum="E9B344AFF2877462" modified="2012-09-05" version="1">MEVLQSITSNLNASALIPQAEVQGADLYAGQDLSGLNLLEKAWVNWYIWWGNPVIATGVMSFLMHEVVYFGRSIPWIIIDHIPYFRQWKLQPHKIPSDWDQWRCTYLVLLQHFTIELPQIWGFHPLAEYFGMLTYQVPFPSVWQMAKQIAIFFVFEDTWHFVFHRALHWGPLYKRIHKQHHEFSAPFGLAAEYAHPIEVGLTGFGTVGAPILYAAFLGEIHIVGVYLWITCRLFQAIDSHSGYHFPWSLNNFLPFWAGAEHHDYHHEKFTECYSSSFRHWDWLFGTDKKYHAYRAKQAAQKKAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHW7</accession>
    <name>I4YHW7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_62229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956235.1">
        <property type="nucleotide sequence ID" value="XM_006956173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHW7"/>
    <dbReference type="GeneID" id="18474724"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62229"/>
    <dbReference type="HOGENOM" id="CLU_1817297_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHW7"/>
    <dbReference type="OrthoDB" id="4566586at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698186" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="15770" checksum="036828E0DA40AD96" modified="2012-09-05" version="1">MKFATALALTSVAAGVSAWSDTFGTIDDQSFSVVIKDPWKSGLDHANTAAVSVNTIENSQPFTSHNTFTIYGDQCTQYVGLPARDDLPYQPQIHLGANFCNRKNLDNLWINYANQHLDVTSDSRCLHNHVIKETRCVIQNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI31</accession>
    <name>I4YI31_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956293.1">
        <property type="nucleotide sequence ID" value="XM_006956231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI31"/>
    <dbReference type="STRING" id="671144.I4YI31"/>
    <dbReference type="GeneID" id="18473275"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59295"/>
    <dbReference type="eggNOG" id="ENOG502SF40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077758_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI31"/>
    <dbReference type="OMA" id="WRESAPQ"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="246" mass="27358" checksum="1A3DC72D20152168" modified="2012-09-05" version="1">MTYIIRTRRDKMEERKSSRFANSVGKKNVSPTLMNARSKLREKISSESPPLSIKSPSSASSFGEKRFYDEEEDFGNLKTPLPKLLHGFEVNSESYSLVTPSPTNSTFATQQMASLKSPSYPSIPSTPTYIDDLPQSPLESPTADVRTVKLSFVPTMSDEIAVMTGDTVLLLKEWDDGWAFVVKLNKEGEFKEEGVIPLESLVDKTPQSRNFTQSVKSIPSRMSLTKPSISSIGSRRSGVRHSSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI47</accession>
    <name>I4YI47_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_56190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956307.1">
        <property type="nucleotide sequence ID" value="XM_006956245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI47"/>
    <dbReference type="STRING" id="671144.I4YI47"/>
    <dbReference type="GeneID" id="18472780"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56190"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_5_3_1"/>
    <dbReference type="InParanoid" id="I4YI47"/>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="167" mass="19104" checksum="40F30D098F7334C9" modified="2012-09-05" version="1">MSARIDLASVTRQNIGTLRRLNGVILPVPYSDRVYEEVQSPELEDFCKLIYYNDIPVGSVCCRIEGGKLYIMILAVLAPYRRQGLGRHMLQHILKAAVSDPEPIIPGDKVQPRKKLGSVYLHVQKENNDALEFYKKEGFTQEEEVKDYYKRLTGDGSRDAYVLRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI82</accession>
    <name>I4YI82_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956340.1">
        <property type="nucleotide sequence ID" value="XM_006956278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI82"/>
    <dbReference type="FunCoup" id="I4YI82">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI82"/>
    <dbReference type="GeneID" id="18473293"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59320"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_1_1"/>
    <dbReference type="InParanoid" id="I4YI82"/>
    <dbReference type="OMA" id="NTETCVI"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="124"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="459" mass="50170" checksum="16C9E87DA4A5637C" modified="2012-09-05" version="1">MDVMGRNADTSQITDTKKETRKLERDRFVPNRAALEANNTIDADNDIEHDPPLLTNEFDKDVVGNNKRIFAFAEPPPSSSSGVHSTDIRLNLSKSTQSRGNQSSQKSLNTQKRNLSKLKPDRVLDAPGLVDDFYYNLLSWSSTNLLAVGIGARVFVWNADDGSVKEICNGEDSNSGDLQSLKWTEDGSYLATGWADSSIQIYDIETGKRLRKMAGHASRIGVLSWSQHILASGSKSSQIHLHDVRVQQHKVGELNGHASEVTGLAWKPLEGYSLASGGNDNVVNCWDWRVATSSSDPAQGRNTEPRWSKRNHEAAVKALAWCPWTPSLLASGGGTGDHTIHFWQSATGARLNSLKLDSQVTGLHFSHHTREILSTHGFPENNIQVHSYPSLANVGAWPAHDARVLHSGLSPDGTMLATGAGDEALKFWKVWESKSGSATTKKDSMSITERGGNKSGNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIG9</accession>
    <name>I4YIG9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_31249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956424.1">
        <property type="nucleotide sequence ID" value="XM_006956362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIG9"/>
    <dbReference type="STRING" id="671144.I4YIG9"/>
    <dbReference type="GeneID" id="18471270"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31249"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_2_3_1"/>
    <dbReference type="InParanoid" id="I4YIG9"/>
    <dbReference type="OMA" id="EGHENFD"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM23761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="450" mass="49694" checksum="3923D31614E37EB6" modified="2012-09-05" version="1">MIQSPRTPTFNTAHGTYFMPKPTRGNSKANYDEPEGKKHQIGGVIPDNNYEYDEEVEHDEEPTGDESLHTNRQKMKNDDFEQPNSDDDEDYEGQVGGELENKHEEADDAQERIEESKDENNENDYNYWFRVREVIREPLAEFLATCIAILIGLCANTQTMIYTRSITAAYSNVNLAGGLGATAAIYIAGGISGSHINPAITLMLAIFRGFPWTYVPRYFVAQLLGAFVAAGLTWAMYGVDISYIDPLHRVKGDGATANLFVTEPFTEHGTPVGVCVFQEILAGAILTVTVLALGDKDNAPPGASLGGLIIGLVIFAVGTAMGTLSGYATNPVRDFGPRIFLASVGYSSELWTHDKCWFVLGPLIGTFAGTILGATVYDTFIYIGVGSPINFNRTQWFNCLGRSGKSFVRIPRRTAKRSHNMVRYVVGRKNRNEEKIKKWESSQRKGEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIK7</accession>
    <name>I4YIK7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_27247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956462.1">
        <property type="nucleotide sequence ID" value="XM_006956400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIK7"/>
    <dbReference type="STRING" id="671144.I4YIK7"/>
    <dbReference type="GeneID" id="18470983"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27247"/>
    <dbReference type="HOGENOM" id="CLU_1246198_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIK7"/>
    <dbReference type="OMA" id="SITEANC"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="143"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="224" mass="25686" checksum="485A627268D6713E" modified="2012-09-05" version="1">MFPSSAYAIKPETNVFEETCKEQNSKAYNDLLPITGFDLFRNYSFAGTDLNYQSVSLPQLQINTQQSTQLPNQLPDRRGSDETTSSNNSDYNHANNRTVKPRKQSYNSIVSDDVDVPAIMKPVGRRGDASLHIAEDGRMLTKEEQRRLSTERNRLAAARCRKRKSLWTRSLQDEVDNLLNEQKNLKEEKEKLTNEVQELRDTVSELMNQSVSTNSNYLSNNLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIM3</accession>
    <name>I4YIM3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956478.1">
        <property type="nucleotide sequence ID" value="XM_006956416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIM3"/>
    <dbReference type="STRING" id="671144.I4YIM3"/>
    <dbReference type="GeneID" id="18473351"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59429"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423478_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIM3"/>
    <dbReference type="OMA" id="FFRCDPC"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14724">
        <property type="entry name" value="ZIP_Gal4-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="628" mass="71039" checksum="D6C77BEED9BE2994" modified="2012-09-05" version="1">MPKNENTLKRGQACLSCRKRKARCDGEKPACGNCIKGNKECVYIDISGRNAAVRKDKVQKLEERIRDLEQRLESQHISPAMENDIADDELLDNYNMDTTSSLAGFSGVFASPAHQFHATLTPPPSNSLASIEWPYPPLDLTLHLVDTFFNSCPFVAHHLHKPTFFQKVLLPSSHPEAPHPSLIYAILACASRHSPRTSNPEVDDEIFLYTKNHNTFFDMATSIAIQCLEDESVSRNTIEEKAKTISAILIIIYLMKTEGKAINLHRFNALGMRGLISLRFHIDQSMTNARHQLVPLKNSFDKEQRKRMMFLFYIFDVLYSSDHVAYPGNLSSRHILLRLPVPSEVFARATRDTIILDRGPFINSPSWFEERHMDGFQCVIKSTILMDKVNQFLHESIQEVTNQNLSASNQLPAFGELDMLLTNHQSQLPDCWENYNGGNFNIDNYFAHVIALNALINLHNGYMQDHFSKRRLLGCVKSALSVIYSLLNTSFELSKLPAFVTSLYVGLAEILIAAYNQTNDATMRGSIKGELSTFIEVLNRMKKRIPLAFHSLQRLSNSLQRNGIFIDVGEKVIPTSNYVPIVEHISSFDVAAPMPQDTDIFNSFDITEFGWMDENLGEDVLASVGEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIZ2</accession>
    <name>I4YIZ2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_66817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955773.1">
        <property type="nucleotide sequence ID" value="XM_006955711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIZ2"/>
    <dbReference type="STRING" id="671144.I4YIZ2"/>
    <dbReference type="GeneID" id="18475157"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66817"/>
    <dbReference type="eggNOG" id="KOG0508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498944_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIZ2"/>
    <dbReference type="OMA" id="ASHKPAN"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM23934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="546" mass="60370" checksum="60D98F46430E60D9" modified="2012-09-05" version="1">MNDPLTTEFNYEQDFKYDESNDEEEEEEFIYQPQDNLEEPEREVSQQFENSLQLNTSGDKSDDEVIDSLFKAASIGDIDTLTLIQPSFTQSNETNKRSGITPLHAASTNGHLDAVKYLIEEAGAIVELEDREGETALLRASHKPSNIPIVTYLLSIGANVAHADNDGWNALHNASANGSEDAVRIILNNANKSIIDSLGGLQAGPGYTALMNAASRGHLDVVKFLLTEASAPADPFIRNKSGATAYSLAAESLHFDICEFILNAEKALVKDPLLYNPLEYHQSVPIYLLENQRLDCRLSTLAKTGGVPRWSNSGLGQGGRRPKWELPDSRPVDLSDPFNDVQIPSIAKPFTVNLTSISGKPSSNRGAYFWTTDDWLVWKSIGKEDGEGWMYAHDFSAPNSEWKINKTKEIETLEKGSGVGSIKATQMFGGRTGKSGSKTSASENVDKNYWVRRRRWVRILQRDPTLTLPYNSPELKIPKSKQVEMTDIGVQKSPEEQKLKPKKSQSIKKSHLNAKSTPFNPANAISMSTPSMPTATTSFSARFPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIZ7</accession>
    <name>I4YIZ7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_34444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955778.1">
        <property type="nucleotide sequence ID" value="XM_006955716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIZ7"/>
    <dbReference type="GeneID" id="18471863"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34444"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="InParanoid" id="I4YIZ7"/>
    <dbReference type="OMA" id="HHRMRRW"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="32"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="863" mass="95016" checksum="611213E25A0BBD22" modified="2012-09-05" version="1">MSYYGLLAKQNPLNDETNPVKNITVFLLQLIIIIILCRILSFGLKYIKQPPVVGEIIAGILLGPTAFGAIPNFTETVFGGENKALLTLTSNVGLSLFLFLVGLETDIDLMKRLWKETLVTTIPGLLIPFGVAVGVSVIMYREFADPSINFIGFFLFIATSMAVTALSILSRILVELNIIATKLGAIAIAAGVCNDALGYILLAISTAVSSGGDQLNALWELLCLIGLVIFCWFVIRHVISYFYRRNEYQLTTGIATMTIVGALISSWFTDILGLHPMVGAFAFGACCPHEHDFPEKMTEKIETPVMIFLLPLYFVASGLNTNFILLDSGKAWGLIFLLLVATFISKGGCTAVSCRLVGLPWRQAMCVAFLMQSKGVIELVILSVGLELGVISELVYAQLVMVFILTTLTVRPLADWVYLNRIDLNAHPGNEKEDTESGIVDHPSQDTQSIVMVFNTMAPPLSPALKFISLLSHSKSYNVTNLHLHAIEVTSRAYIVRATAAEYLGHSHMNINSEGTHLVEGLTSFQRLSGVKCLGKSTSLLAERDDHVRVALEYVNNIDRNGMLITPWIPSGSTFGTKAMLTAEAGTPRSFAGALLKESKNAIGVVIQPLDILVKHTTKVAKSDRKPKIILPYFGGKDDETALEIVKKMAANDGIDAHIIKFKIKSESEETKRKQEAELNEMIPNNQPKKSTDDTLHGQVTMVAPGIQQSRGLSYVFNRRESHDVVPSTEIENEIIIEVEAENIISSMIDHLQQVLVDGHSEDMLIVGRGKLDQQRTSLFRSQADDMLNNNKYQITNDELNEIKDLGRVLGSVAQTLTLELGCMYNRNEAGCPQMLVVQSSTDKEQIESPPKYKEDDQDNKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJA0</accession>
    <name>I4YJA0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_9879</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955640.1">
        <property type="nucleotide sequence ID" value="XM_006955578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJA0"/>
    <dbReference type="STRING" id="671144.I4YJA0"/>
    <dbReference type="GeneID" id="18475855"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9879"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129373_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJA0"/>
    <dbReference type="OMA" id="TAFIAKI"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM24042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="102" mass="11194" checksum="167FED1D63F0E093" modified="2012-09-05" version="1" fragment="single">LSDLLQLQKKPEISTPYDPVHLTHVGFNSDTGEFTGLPKEWQQLLQDSGISKQDQEANPQAVMDIVAFYQDAQKAQLGAEDSQVWKKMGGVANGQPTGPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJC7</accession>
    <name>I4YJC7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955896.1">
        <property type="nucleotide sequence ID" value="XM_006955834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJC7"/>
    <dbReference type="STRING" id="671144.I4YJC7"/>
    <dbReference type="GeneID" id="18474693"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61898"/>
    <dbReference type="eggNOG" id="ENOG502S7WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161922_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJC7"/>
    <dbReference type="OMA" id="HITQYEK"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="24613" checksum="90D19EFE5A8145EC" modified="2012-09-05" version="1">MNQMNAQQLAMYQQMMQQAAPPAGGMQQMRPQLNQQQMMMVLQQQQQAQAQAQAIQQQQQAQHQAANIQAQRQRMMLLQQQQQQQQQQQQAQAASQQQAQALAQQRLQAANRLDRPSLVESNDSYEQIDSFSHRDLAISRFRLNHDLLADVFSPYHIKQYTPPEPHYGNEDIPRLQEKLAELEKETSQIPEKHDTQVRDWHSSFEKLQTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJP6</accession>
    <name>I4YJP6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_67034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956008.1">
        <property type="nucleotide sequence ID" value="XM_006955946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJP6"/>
    <dbReference type="FunCoup" id="I4YJP6">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="18475202"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67034"/>
    <dbReference type="eggNOG" id="ENOG502SBA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1403430_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJP6"/>
    <dbReference type="OMA" id="FDRHIWS"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="192" mass="22583" checksum="06CC58EA880E2BD5" modified="2012-09-05" version="1">MDINYPKIDLESKEHLKFLEGYYKNELFSQIDSSDDSNDALKCLLNSYFNKTFSLIHPNIKINGQNYQDINLDDEVEFEQFDDKLRTQMSELDSNIEQLQNRLSEKRRIVPLELEELLSRQLRRQKPSNQDPNLEDEASPQEEESDKCVEFHKEGLDDINSNINTLLSKLPQQISKLDRAKNLQNDLKSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJS1</accession>
    <name>I4YJS1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956031.1">
        <property type="nucleotide sequence ID" value="XM_006955969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJS1"/>
    <dbReference type="GeneID" id="18475205"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67051"/>
    <dbReference type="HOGENOM" id="CLU_1769520_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJS1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16778" checksum="5C8748C4BEAD82BF" modified="2012-09-05" version="1">MSESDKIKELNIRDLLNLSNSLNKSIKQLEHSRQQLIFDHHYELIVSSDKISGMKQSLEELTPTAEKLNEQLSKITKVEDLTKLKRVVLIEQIVSLPDKLQLLVNDGKLDAAISLYNQQRNNIEKLINAKIEGVSRINSKCMSIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJW2</accession>
    <name>I4YJW2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_26932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956070.1">
        <property type="nucleotide sequence ID" value="XM_006956008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJW2"/>
    <dbReference type="GeneID" id="18470967"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26932"/>
    <dbReference type="HOGENOM" id="CLU_1305721_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJW2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="25005" checksum="DB1601EC63164F8E" modified="2012-09-05" version="1">MNPNRLLYRCRKTDLESCRYFIWVDDFEKAADNQLNNENYTLRTRRRHILDACKRRNDANKLSRWSTKLVDDVLAEFDKHDDEITNFSDDDDFIECSRQPNKRLYDVDSDNKEELPSTPKRPRRLSPPGQPRHRKVSDFFKKIDEKGAKRERSDTNAQLDTNELINYVKSTERSHAGLAQELEEAKGEIRKLKKEARVYNDIIGKLYKLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJZ4</accession>
    <name>I4YJZ4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_62104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956098.1">
        <property type="nucleotide sequence ID" value="XM_006956036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJZ4"/>
    <dbReference type="GeneID" id="18474710"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62104"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033641_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJZ4"/>
    <dbReference type="OMA" id="YFPCGMY"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM24286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="305" mass="33664" checksum="0B83E82BDDEBE941" modified="2012-09-05" version="1">MNPREFWYYIGLYLLFNLVLTLFNKAVLDNFPYPYTLTAVHAAANVIGSTIARLYGLYTPAKLSNTEIVILVLFSTLYTINIAVSNLSLNLVTVPVHQIIRSLGPLFTMALSVPLLGSKFSIPKLISLLPVMIGIAIMTYGEIDYTIIGLVLTFAGTILAAIKTVVTNLMQTGQRFQLHPLDLLFRLSPLALIQCVGYALYTEEYFEVYKDLWPMPNVYKTVLLILLNGAIAFGLNVVSFVANKKVGPLTISVAANIKQVLTVILSFFFFEVAITGVSFSGIVVALLGGVWYGKVEYTEKKRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y519</accession>
    <name>I4Y519_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_49592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668264">
        <property type="protein sequence ID" value="EIM19061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960894.1">
        <property type="nucleotide sequence ID" value="XM_006960832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y519"/>
    <dbReference type="GeneID" id="18472503"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49592"/>
    <dbReference type="HOGENOM" id="CLU_2833114_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y519"/>
    <dbReference type="OrthoDB" id="5549518at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="66" mass="7986" checksum="57E2661D6A128E21" modified="2012-09-05" version="1">MEFTTHFELHSQTTRLLESVSHDHSNLHQRREFHPLCQPIPRYLYAGYNRKHFLRLQCGCLKDNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5A3</accession>
    <name>I4Y5A3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_49449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668257">
        <property type="protein sequence ID" value="EIM19145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960807.1">
        <property type="nucleotide sequence ID" value="XM_006960745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5A3"/>
    <dbReference type="FunCoup" id="I4Y5A3">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5A3"/>
    <dbReference type="GeneID" id="18472496"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49449"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031381_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y5A3"/>
    <dbReference type="OMA" id="LECHYEY"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="34013" checksum="4A9AC0DC51345335" modified="2012-09-05" version="1">MRIKIRTPTQKILKFGMTFDAEKTVKNGATVTYGPWNNVESYSIPTSPIEILYEAAGPRLLYESYDRHLELSHWGNAASYRDDIVLRNNGPSLKGHFTRLTHQAQTFLDMLPTNVVTSLEMRLPAKIKEAFYVDQIGNVTTSVFRPSTSSSSVLQVKPRFPLLGGWKYSFSVGFETLLRNVATLRNNGDTKVTVPFSNIPGDVAVEKAETRIILPEGANIIDVILPFKEVELDYETTYTYLDTIGRPTVVIKKLNASDAHNQDVVVIYNLSLLNAIRKPVTVGLTVFLVFLAFSLLRRINTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G5</accession>
    <name>I4Y5G5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_61560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960704.1">
        <property type="nucleotide sequence ID" value="XM_006960642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G5"/>
    <dbReference type="FunCoup" id="I4Y5G5">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5G5"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61561"/>
    <dbReference type="HOGENOM" id="CLU_013399_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5G5"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="128"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="483" mass="54245" checksum="4D359B7D42CCFA74" modified="2012-09-05" version="1">MTMKTKMIFQLKNEIDNNITVIVPDEEKGLTIRTSDPKMHPKKNSRSCTSCISKQKNYQQVDSDGGIKETYINYWRVVNCSLDQGIISLSVLTPGHNSLLDFSGIPIELSTEEVDKVVQYIRFKSKLRTCRRLKALVNPVGGTGKAVIYWNETVLPILRSSGCYIDMQILEYKGHAFEIAKKLLLNYDAVVCVSGDGIMHEVLNGFMYHETPSDALKTPLCPIPAGSGNGISVCVLGEKDGFDLSMAALNAAKGQTIPLDLFSIWQERKRTISYLTQAGGLMASLDVGTENLRWMGDTRFTVGYLRSLIKNAPCNCEVYVNVEEDNKHEMIKCLRERKLDDPISVPETDTFPPVKYKNGPEDDWVKISDDICYIYAGQVPWVSRTFKQFPVALPDDGYIDVAVQLNVSRRHKLLAMEGAENGAMFFDDSLKYYKAKAYHVNPINKNQYLAVDGEQLPPSPFTVEVLPSMGRLISPFSSWNNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X7</accession>
    <name>I4Y5X7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960519.1">
        <property type="nucleotide sequence ID" value="XM_006960457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X7"/>
    <dbReference type="STRING" id="671144.I4Y5X7"/>
    <dbReference type="GeneID" id="18474550"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61471"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y5X7"/>
    <dbReference type="OMA" id="QTESHIV"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="473"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="971" mass="106960" checksum="C16921700DF9CDD1" modified="2012-09-05" version="1">MLKGAVVSGNQMLALSNRNSVPALAHLIKSTDTHNLLYGDTSIQLTNNAMEVKSILTKEGFEVNLIKAPPVSLLFPEVSDKEFDAHLDPLPAKFEDDKKSPIILHSSGSSGSFPKPIYLSNETIRSWALSHDNSNAQDILSLQGKKFYSGALPTFHAMGFYSQVISSLSSTVTIAIPKVSLPPPFPTPESIIENIKRTNSDIAIVVPSIIEKWAEDASTVEFLKTLKLLLFGGAGLSSNIGNMLTAEGVPLLSVYGTTETGPSCSCFTIRNSENSNEWGYSILSSNHNARFIDQGDGLFELHFLNNGKHIPSVNNLDDALGYNTGDLVERHPYKKDLFKIVGRSDSQIILASGEKTNPEPIERLIDSNPLVSRSLMFGRHRTSNGIIIEPSFSISNSEDFLDSIWPSIEAANDHAPQHSRLQRSLVLIATEPFPLTPKGSVKRNATLEMFQDEIEAAYNKADEAVAESVPFDISNVRASVSNIVNSVMGQSLEDVDLVSQGLDSMQATIIRNKLTSALKAFKDVNLNATIVFQHPKITLLSEYVDQILNDDKKELSEEELVDMKAAEINATIDRHCDTIKAKVSNKWEEPARECNKVLVTGTTGGLGAQLLVTLIRDATVDHVYAVNRSNAINSLKERQIKALAEKGIPASEIVNSTKLTLIEADLTLPDLGLEEKQYREIEEEVDVIIHNAWRVDFNVALQSFEPDIKGVVNLTNLAITSKHGAAVLFTSSIGSVSRWPVGRETVEEPLTDARMAVGMGYGESKFVGERILSYASSKIGLPTTVLRIGQLCGDREVGYWTSSNWVPAIIKSGVSLHCLPTGDDIITWISLDDAAKAIVDFSHNRRSSKIHDLLHVVHPRPRSWNDIFKVVVNALNKKGIEVILVDYQTWLSKLKSEDTSKMVENPAIKLLPMFESGEVSNTRREFVEAMGNPILQTVRSQEASATMRSCKELSDGDVLKWMDSWFNERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6U8</accession>
    <name>I4Y6U8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960198.1">
        <property type="nucleotide sequence ID" value="XM_006960136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6U8"/>
    <dbReference type="STRING" id="671144.I4Y6U8"/>
    <dbReference type="GeneID" id="18473034"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58564"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994667_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6U8"/>
    <dbReference type="OMA" id="CKAINIW"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31019" checksum="8B593CC9E6219A4D" modified="2012-09-05" version="1">MLRTIVNSVKRHRTFEEINNFRVKLENGRPLVSGDNSYGQLGHPESVSSIEKPTPVPNLNERLEAAHSSLSNVYLTTRHTVLSAGLNTDNQLGRSFNHSLSHTFKQVEWDFGRFDGVKQLSTNGDTATVLTMDGSVVGWGNSEYGSLCSVEDKGVEPRNISEHLDKAGCRYITKISVAGAHSWFLNDTGEVWNVGLQLVDENPVISPIPNKLELPCKALNIWSGVHHSAAFLEDETLYISGPQLDRFTITTNQNKGDLERLVKSKTLDSTFGFNSILLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y710</accession>
    <name>I4Y710_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_70416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960260.1">
        <property type="nucleotide sequence ID" value="XM_006960198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y710"/>
    <dbReference type="GeneID" id="18475732"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70416"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263940_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y710"/>
    <dbReference type="OMA" id="WAFTLAW"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="285"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="527"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="957"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1215" mass="140580" checksum="C3E7DB4BC8BD5EF1" modified="2012-09-05" version="1">MADCDARCDDKYSSLLTQLYVSLGIGGSSIILFESIRRLKRRNLPSYPQTNEFRKERYIFGYLYYFRCFVDPASDRHPGWPLQWIWQVLKLKQSQITDMLGGDASVYLHWLKVCLCFTLSQTITVVPILLPIHFHFTSTPTDSSMNTASLTHLIDNSDGRELLYVHVILHIWTSITWIIALLWYINGAIKIRERMAYKSSEFSTSPVDNSWKSRTVLVTNIPNSLRDERVLASYFAFYLNRFKKKKTTNLSRRSSILSFNSLLERVDQGSIPDINNTDNLEELTENYIEDVSIIRKFERLVQLRKRLDDATKRLELAYLKLSRNLLKFVRKHIEECLRKDEEFDKDDILINSLMPFVYEFEKQPTKLSFGLSSTINKLLRRNDAFIRCPDTPASMQDNKTIWEVIFSLPVSVIEPFQPKIRVKPILKTIMTKSDNPTVSEIHYLTNKVRLLVASIEEYQMNSPTIFPPTSTAFVTFKKVSDARVTCKKLSSHPARPNACIVKPAPYFSEIDWEVAITSKSATTTVRGMIIKVAIWGFILFYIIPMAALSSLFSIERLRDVNADLGAYFDRHEHQAEIFTTLVPTLLVAFISLMMPAILFGIGKKAQPHLTIHRLHDQIFHRYWVFMITNVLITFCIGAATFRFILESFTSASGLSILNRIYLSFPQAAPFFASWAILQTSIQNFVQLALIGLPLLMFLFKTLSAKTPRARKEATRARTPDYHVFCSNTLLVISVLLVMGVFNPLVIPFTFIYFIAANIVYRNQLYHVYSRRLYDTGGKWVTVRVFRYGMDAMAVSQVAFFAFHLVRYYDGRKNHSGTYTIIIGVFFIICLILKLLITRQIKARFDAIEFLDGLWKSGETLNYTEIYSSPTLELRFAEYIEEKYHSQPLTKNFVKHKETLGFRIRDFLLITHFTFRSFLSDFKKEVRETFVRIRRTFFPFLPSSKRIPREIFARKSTADDEQVLKHEHEREQEEEREEEQEVEHDEWEDVIDAATEEEGSNEPLTMTNTISMENLKHVNALKSSRGQRGSFMKKLNDQSHELFKPFLHIGQIFSSANNRIQKVGLHREEQGEIEDLMVCKHMPEKPSSDAPDESLSYNCPFYYDLLEPYLLLPRDPTSAIDLDDLVEIHYGKSLQNGTEITDNDTPEDELTSVSGTIPETQEEHDAEHSDELSSPSGSSDFEHIRLSTVNLTQLNRNQTFRQTLSPRSPNNIDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y730</accession>
    <name>I4Y730_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mkh1</name>
        <name evidence="9" type="ORF">WALSEDRAFT_33780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960107.1">
        <property type="nucleotide sequence ID" value="XM_006960045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y730"/>
    <dbReference type="STRING" id="671144.I4Y730"/>
    <dbReference type="GeneID" id="18471745"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33780"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="I4Y730"/>
    <dbReference type="OMA" id="DAQQCIF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="57"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="352" mass="39736" checksum="94EE09C628770BAC" modified="2012-09-05" version="1">MSQSNLRKSPVIDDRAGLKRRSTVFWGNKVVQVQPNERERQEQILSPVTNEPSTIKWVKGDLIGKGSFGHVYLALNANTGEPLAVKQIALTAHSDEDNDGDDKLVDSIKYEIELLKDLDHDRIVSYLGFERTDKFFSIFLEYVPGGSVMRCLRRHGPFEEDLVRFFMRQVLDGLVYLHDRGVWHRDLKADNLLVDFEGNCKISDFGVSKAADSDAYGTNAGATNMKGTFYWMAPEVIDSVGMAGYSAKCDIWSLGCVLLEMLTAERPWPKMTMVQIVMEVGQKRSAPPVKEGIEMSQDAIAFKNACFKAEPRERPTASQLADDKFLTIDKEWNFKDSRLGQTIRSTNRLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y741</accession>
    <name>I4Y741_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960117.1">
        <property type="nucleotide sequence ID" value="XM_006960055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y741"/>
    <dbReference type="FunCoup" id="I4Y741">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y741"/>
    <dbReference type="GeneID" id="18474438"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61282"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y741"/>
    <dbReference type="OMA" id="QIQATHQ"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="672"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1162"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1250" mass="140252" checksum="C38BEEFF1E69D715" modified="2012-09-05" version="1">MADSNSSQHNPKNRRTPRHDRRQSTQLYNPDDNTHSSLDMPPLPVQNQQRNNNGHRKTASMNPNPQDRNRRKNLAPRFQEDQVEAEGEVDSYGTLNQNFQFGAKRRTTPNSISFSNHTPSQSLGGGNYGHPLNNMTPEQLLIQQQIEALQHQQRALIQNQSQFVQQYDQQTLNSRMNTAGANNHRRIQSQQVPNMRSPNFGQYSPQSSSLYNPQSPQMKNIPKGHGRRHSVNVSKVTQDLDNFSFPPKNPNSGNIPPGHARRISTGQAIQQPVAINSQSGVPDLAQAQSQLASLAQFRVGVGAGGHNRAQSFAFPNAFQNMVAAASLSAALGGNQMGKFDNGINYALQQQQAFNLQLQQPGGQGGPQRKSLFAPYLPQASLPPLLTAGKLVVGMLRVNKRNRSDAYISTEVLDADVYICGSKDRNRALEGDIVAVELLNVDEVWGTKKEKEEKKRRKEENAQYDALRAINPSIETKQQAKNRDDVEVEGQGLFLIADEEVTDEQKPKYAGHVVAIVERMPGQLFSGTLGILRPSSAATKEKQDAERREREGGIPQAQEKPTQKPKIVWFKPTDKRVPLIAIPTEQAPKDFLEKSEDYQNEIFVACIKRWPITSLHPFGTLVEKLGTIGDVEVETSALLKDSNACFSEDFSENVLKCLPSLPWSIPEQEYMNRRDLRNERTFTIDPDTAKDLDDAVSIKLNEDGTYDITVSIADVSYFIKPNSALDKDARKRATSVYLVQRAVPMLPSVLSSDLCSLLPDKERLAFSVTFTMTKDAKVIKTWYGRTIIKSCAQLSYQNAQNVIEGKSLDAAKEKLSDLHSSDEIEGDIKVLFDLSRKLRQRRFDNGALKIDSMKLSFQLDDNGVPIDCVAYQSREANNLIEEFMLLTNMSVASQIAVNLPEQSLLRRHEDPIDRKLEGFKERAKDLGFDMDISSSGALQKSFSDIKDKEASSMLQVLAVKGMCRAKYFCSGAIDISAYKHYALNVPLYTHFTSPIRRYADVIVHRQLDTVLQFGEDAENKFGTGERETIAKIAQQCNIKKDASKQAQESSQHLYLCLLISDLTRRYGPVVRQATVIGVLDRAFDVLVNDMGIEKRVHVDKIPVDNSEFNEEEKTLDLYWKNGVDVISWLADNSSDSHLRRIQEMASKHAPSHMTSRSTQDESALFDDDDEEDDDEDEDNGIPNDTNDNDNIQTVQHMKSKQVYEPKYQNVRIDNGNYIQTIKERMTVDIIVTADFSASPPILKCYCGNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T3</accession>
    <name>I4Y7T3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_61191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959954.1">
        <property type="nucleotide sequence ID" value="XM_006959892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T3"/>
    <dbReference type="FunCoup" id="I4Y7T3">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7T3"/>
    <dbReference type="GeneID" id="18474383"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61191"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032730_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T3"/>
    <dbReference type="OMA" id="MHHPPES"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="238" mass="27497" checksum="83E5BA95BF53E1C6" modified="2012-09-05" version="1">MNLSFTVGLLIGQSSVILLLILIIKYFIFSDVDVAIEKKRKKKLKRGEGLDENVYKYKTKYESVEWINSLLSGYYGVYREYLDSNGVEIIENLLNRRSIPLLDRIEVNNFEIGYKYPQLSNARITEKGECLIDFDYNDQLLVETSSKFIINYPRERLASIPIDISIKLIRFNGCVSMSIEGGYMVVSLHSNYNLILKCQSQLGSKAKLQDIPKLEEIIINNIDNLLTTKFKQFKIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V6</accession>
    <name>I4Y7V6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_65840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959977.1">
        <property type="nucleotide sequence ID" value="XM_006959915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V6"/>
    <dbReference type="FunCoup" id="I4Y7V6">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7V6"/>
    <dbReference type="GeneID" id="18475056"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65840"/>
    <dbReference type="eggNOG" id="KOG1407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045202_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7V6"/>
    <dbReference type="OMA" id="WNADGRH"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="38820" checksum="369246C638FE0DEB" modified="2012-09-05" version="1">MASLTNQGDFPYDVQFPSRGILPPDFKAWGSASARAHKDRVNAVGWSNDGKRLGSVSSDKSLRIWPEKALDSGRPDAKMATAMIGHSDKVVQLAWHPLDSNLLTTVSLDKTIRCWDIRARAPTTTLQLSSAAYNLAYHPDGQTLAAGAETIGFYDLRHPTGPQRTIERQQQADRINHDFRWSKDGELFTICCNDGSFEAYLYPSFELEFSDKGHTSDATKIEFTKDRRYMLTGGGDAVVNVWDLEEWICLRSINQIEGLVRSISVNSISECVAIGTDDRNISIASIHTGETLHSFKTGAKTKSLAWHPSKLLLAYASEDITREEHMREPGMMNISSSVRVWGKGVGRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7V7</accession>
    <name>I4Y7V7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959978.1">
        <property type="nucleotide sequence ID" value="XM_006959916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7V7"/>
    <dbReference type="GeneID" id="18471727"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33667"/>
    <dbReference type="HOGENOM" id="CLU_1807711_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7V7"/>
    <dbReference type="OMA" id="PQEACTH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="13958" checksum="71189F1726D0015F" modified="2012-09-05" version="1">MPAAPPGRSTPAAPPARATPPPPARGTPVPPAPPASSTPPARTTPPAPPIGRLPPPVPPVAAAPTKKPPPPAPKPKPKPPAPAAPPAPAAPPSQPPRVLPPGPPPGQPARSIPPPPPSRPSPPPAPQRNAPPSLPSRTPSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7X9</accession>
    <name>I4Y7X9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959792.1">
        <property type="nucleotide sequence ID" value="XM_006959730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7X9"/>
    <dbReference type="FunCoup" id="I4Y7X9">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7X9"/>
    <dbReference type="GeneID" id="18474334"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61105"/>
    <dbReference type="eggNOG" id="KOG2473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016809_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y7X9"/>
    <dbReference type="OMA" id="SKAPRIW"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="420" mass="47826" checksum="B3C8ED26CF9DD58B" modified="2012-09-05" version="1">MADFTSNLPEPTFLDSLNEKIFSDNINESITALRNIQLPKKADHLQFIENRVKDNRLRKTRGESIEGLHNQPIGLIQPPVFYRTQVFNNYLYQNKLNPDESIGVNKATGQPYKRLVSRNRAKVDSGFSIAWDHYPVPTSTTKEASDFIKHFPRKDLLERLESLFNGRPCWTRAALMNQFTPQEARFLLNQKLSVTVFSYTFHSGPFADTLCRIGWDPRLDSGNRIYQRIQTRILGINERRHRGLGGRASGVNAAARASTATPSTPAPRANSITRYFTPVNTTGNAPTTPEHNPMELNSESHIFDGKHTPEATNFQICDIHDEDCKKLIADEQGHNQTFDYVTGFFTTEQITRIRGVLKRKIIVLKEENRQLTEEELAQLLIPGAMQNDSDEETTQQTPLASKSTRQKARNLRETILSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7Y9</accession>
    <name>I4Y7Y9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WALSEDRAFT_61112</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959802.1">
        <property type="nucleotide sequence ID" value="XM_006959740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7Y9"/>
    <dbReference type="FunCoup" id="I4Y7Y9">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7Y9"/>
    <dbReference type="GeneID" id="18474338"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61112"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009667_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y7Y9"/>
    <dbReference type="OMA" id="INFQNCV"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EIM20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="595" mass="65410" checksum="967D845A20C0DDBF" modified="2012-09-05" version="1">MLRRAVSRISLNNKRCLSTSRLSFKNGVDGLRTSPFNFVKNAERAEDECDVCIVGAGPAGLSAAIKLKQLNEDLRVVILEKGPEVGSHILSGAVIEPKAIDELFPDWRELGAPLNQPATADSMKFLTKNYSIPIPHPPQMSNSGNYIISLSRLCAWLAEKAEELGVEIYPGFAAAGINWVDGKVGGVVTNEIGMGKDGEPKDQFEPGMIFNAKTTLLSEGAHGSLSQKIINHFNLREGKDEQTYGIGIKEVWRVDPSKHEPGNITHTVGWPIDNETYAGSWCYHMEDNLVSIGLVIGLDYKNPYISPFREFQRMKHHPIFKNLLEGGECIAYGGRSLNEGGLQSIPQLHFPGGALIGCSAGFVNVPKIKGVHNAMKSGMLAAETVNENISKEEEDFKPASIDMTSYEQKVKDSWIWKELNEVRNIRPSFHSSLGNLGGIIYSGIDSLFLKGRTPWTFHHPGPDHAQTKPMHDYKPIEYPSPDGKLSFDILTSVSRTSTNHEEDEPVHLKLTSSPKYHTAQNVGIYAGLLGRACPAAVYEYRDTKEDGGQEDALGHKFVINSQNCIHCKLCSIKTPTQDINWTTPTGGGGPKYSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y879</accession>
    <name>I4Y879_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959891.1">
        <property type="nucleotide sequence ID" value="XM_006959829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y879"/>
    <dbReference type="FunCoup" id="I4Y879">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y879"/>
    <dbReference type="GeneID" id="18474367"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61164"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="InParanoid" id="I4Y879"/>
    <dbReference type="OMA" id="DFFPGVM"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="9">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="439" mass="49432" checksum="59CF0E9DBE482855" modified="2012-09-05" version="1">MDPMILALSGSKPPTHNHYHHDWFGYDSSGTRSKRLSVNHQSLQKPRKERLNDLKNEKKYAINTSLSLEKPPLEVICQVRTRIPTPHGEIFCHLYTNNHDKKEHLAFVVDPEQLQREFVSSNDLRSKSLDAIRSGESELDRLTRGAYVGKIKRNSAEINIASTNSLNASPYTLRQEHKDPLAPLVRIHSECYTGETIGSQRCDCGEQLDEALRQMFVGTSKDQHTKPRGVIVYMRQEGRGIGLAAKLRAYNLQDLGHDTVTANELLGFGADERTYEISASILRDLGLGIGSSGIRLMTNNPDKVNALEFEGIPVSDRVEMIPRAWKCNHLEELKIKGLKQKHLFANPRRFSTGGEQTPTCVNEKGEEEDKDVFAKTLSTAENDSGDEYLQHVLRRSGAGLIGAGATQGEDLERYLRTKIERMGHLITIPKDKEQIEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y893</accession>
    <name>I4Y893_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959673.1">
        <property type="nucleotide sequence ID" value="XM_006959611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y893"/>
    <dbReference type="GeneID" id="18474303"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61043"/>
    <dbReference type="HOGENOM" id="CLU_2795883_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y893"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="68" mass="8299" checksum="FE3DC198AC806166" modified="2012-09-05" version="1">MSTSGLYKKFFMNNYNYKLENISEVLKPNHDQGHFQADREVYRAQFQRKSCDNKRFHLLSEQLRYVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8B1</accession>
    <name>I4Y8B1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959691.1">
        <property type="nucleotide sequence ID" value="XM_006959629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8B1"/>
    <dbReference type="FunCoup" id="I4Y8B1">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8B1"/>
    <dbReference type="GeneID" id="18475670"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69973"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y8B1"/>
    <dbReference type="OMA" id="TKQYWKD"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697699" evidence="5">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="74"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="410" mass="46877" checksum="22AA0B4643162ED8" modified="2012-09-05" version="1">MVKLLQSLAALSAATLAAATPVYRKQDAGSGVLRGVNIGGWLLMEPFITPSVFDNTLDDKIVDEWTFGERQDEEVATRAVNDHLETFITEDDFAQIRAAGLTHVRIPVPHWAFDKRDFEPFIVGNRVEKLREALKWCRDYELKAWIDLHSAPGGQNGFDNDGQLLDKPAWHTNQAQVERTLYVIQEIKNEFATPEYEDVVEAIELLNEPATFADEGMIPVLKNYYQSGFDIIDGDTEVVLHDGFKEDSHYWDGFLDGTQLDVHRYQVFSPDELKRTDEERIATACSYKQTLQEVTDQHHFAVVGEWTAAITDCTPYLNGRLVEGARLEGQHSSSDEYIDTCEGKTGDGSDWTEEYKDSLRVFWEAQVDAYGERYFFWTWRTELGADWSYQRLLELGVIPQDPTDFTPRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C1</accession>
    <name>I4Y8C1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1000-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_65569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959701.1">
        <property type="nucleotide sequence ID" value="XM_006959639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C1"/>
    <dbReference type="FunCoup" id="I4Y8C1">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8C1"/>
    <dbReference type="GeneID" id="18475034"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65569"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8C1"/>
    <dbReference type="OMA" id="PLAGTNM"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="172" mass="18985" checksum="3A43AEF9A31E6CF5" modified="2012-09-05" version="1">MSSFVNLKDYVDPAGVSCLNVKDESSVKQLLGRTGSRIGLLESDADENLLLSVAFDQTVKVHSLKLGHSVLEYAPKEIKIFINTPELDFDKAEDDLETPKGDAMAVLSLTEKQAIGEDSIQLRFVRFQAVNSIQIYVKSNQSDGDISKISQVDLYGQSIHTTKMANFGKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E2</accession>
    <name>I4Y8E2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_65588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959722.1">
        <property type="nucleotide sequence ID" value="XM_006959660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E2"/>
    <dbReference type="GeneID" id="18475036"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65588"/>
    <dbReference type="HOGENOM" id="CLU_2777830_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8E2"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7853" checksum="978467EBCC3E61F2" modified="2012-09-05" version="1">MVEEQSSKRNSGIKNDKPVWDSWKSLSPRNRMVIAGSVFVFSAIGLYVSDRLEEKYPAVNPALLQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8H4</accession>
    <name>I4Y8H4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_61080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959754.1">
        <property type="nucleotide sequence ID" value="XM_006959692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8H4"/>
    <dbReference type="FunCoup" id="I4Y8H4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8H4"/>
    <dbReference type="GeneID" id="18474323"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61080"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057172_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y8H4"/>
    <dbReference type="OMA" id="NMYTDYE"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="129" mass="14946" checksum="403DD55055B0DD88" modified="2012-09-05" version="1">MYGAPENFLEIEVTNPITHSSGRSKYTTYDIHLSTNIPAFKLKNSVVRRRYSDFEVFRDILERESSRVNVPALPGKVFTNRFTDEVIQTRREGLERFVQIVAGHPLLQTGSKVLCAFLQDPSWDRTQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-03-27" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8I6</accession>
    <name>I4Y8I6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959766.1">
        <property type="nucleotide sequence ID" value="XM_006959704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8I6"/>
    <dbReference type="GeneID" id="18471696"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33508"/>
    <dbReference type="eggNOG" id="ENOG502SDSF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_10_2_1"/>
    <dbReference type="InParanoid" id="I4Y8I6"/>
    <dbReference type="OMA" id="MTIDIVA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="118" mass="12943" checksum="C8A800A9824CC9AE" modified="2012-09-05" version="1">MPSLSESAAAVMPSIQEKLAIISGPFNVLAKVVVEQGHADEVEALLKEVAELARSDKEPETLTYRISRGIKADDHTFIVYEEYTGPVGLGVHTSSPQFQKLAAYPHVVKADLEVYKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J2</accession>
    <name>I4Y8J2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component CSL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_58311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959772.1">
        <property type="nucleotide sequence ID" value="XM_006959710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J2"/>
    <dbReference type="FunCoup" id="I4Y8J2">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8J2"/>
    <dbReference type="GeneID" id="18473005"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58311"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y8J2"/>
    <dbReference type="OMA" id="PMVPVGW"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="187" mass="20754" checksum="52431040786C9157" modified="2012-09-05" version="1">MIVLPGQPVSDNSDKIKHRESVYERSDKLISSTIGKLSKSEDSIRVESAHKNAQPLPEIDSEVLATVVRLNSKQATLQLDVIDGVPCTNNSQDSSFQAILRSQDVRQTDKDRVKMYNCVRPGDIVRASVISLGDAKNYYLSTAKNELGVVFATSEYGNPMIPISWESMKDIQTDTIEQRKCAKPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8K4</accession>
    <name>I4Y8K4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959553.1">
        <property type="nucleotide sequence ID" value="XM_006959491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8K4"/>
    <dbReference type="STRING" id="671144.I4Y8K4"/>
    <dbReference type="GeneID" id="18474276"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60992"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y8K4"/>
    <dbReference type="OMA" id="AGCDSCW"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="159"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="410"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="531" mass="59670" checksum="1C921F715EF98E84" modified="2012-09-05" version="1">MTAGIEILNNVAPQHKAILSDDALEFVAKIHRTFNKTRKHLLQERQQRQKDLDEGRIRLNFRPETQHIRQNKSWICAPPAPGLRDRRVEITGPTERKMVINALNSGSKTFMADFEDSNSPTWHNMVDGQLNLHDAIRRQIDFTDEKSGKSYKLSPNPAVLIVRPRGWHLDETRVLIDGEPVSGGLFDFALYFYHNAKEYINRGFGPYFYLPKMESYLEARLWNDVFNFAQDSLDIPRGTIRGTVLIETIFAVFEMDEILYELRNHSSGLNCGRWDYIFSFIKAQRANKSSVLPNRSDVTMSVPFMDAYVRLLIQTCHGRQVAAMGGMSAQIPIKNDTKANDAAMSKVKNDKLREVTAGHDGTWVAHPALVKIALDIFNDKMLGPNQYHIRREEVQVSAADLLNTNVPGEITDAGVHENASAALAYCSAWISGNGCVPINNLMEDAATAEIARVQLWSWAKYSAKTNSGKVVSAAFVDQVLKEEGKHIKGASETNVNKSIEYLSNQVNSKWPSDFLTSDLISLLDSGRKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Q2</accession>
    <name>I4Y8Q2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959601.1">
        <property type="nucleotide sequence ID" value="XM_006959539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Q2"/>
    <dbReference type="FunCoup" id="I4Y8Q2">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Q2"/>
    <dbReference type="GeneID" id="18474283"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61010"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y8Q2"/>
    <dbReference type="OMA" id="WATIREP"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33623" checksum="BF53FE4A0EFCC3F4" modified="2012-09-05" version="1">MSAKDLYLAEHYLSGPKADAILERAKGKKKKKSKSSTKDGSVTINEDNDLLTSKLDDNDNDDPAVQLVSHSSKFKSIAPPTQASTSTEDNPTVVEDNNDNDFKGGLKSAKQIRQENAQLRAKEEEKRRLEEQSLQNSNQQTIYRDQSGRKIDVKAQEIEAKRLKQERDEAEAKRMEWGKGLVQREDRDKLRKQEEAMKHKSLSKYSDDAEHNAELMDVERWNDPAAAFITKKTSSGPKKPKYTGPPPPPNRFGISPGYRWDGVDRSNGFEQKLFQSINSRKRAVYEHGKWSREDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8R2</accession>
    <name>I4Y8R2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_58217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959611.1">
        <property type="nucleotide sequence ID" value="XM_006959549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8R2"/>
    <dbReference type="GeneID" id="18472997"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58217"/>
    <dbReference type="HOGENOM" id="CLU_1099212_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8R2"/>
    <dbReference type="OMA" id="HDECTNQ"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="277" mass="31116" checksum="3C62D78ED4243729" modified="2012-09-05" version="1">MMIFNIPRSPSTTEEYPHRNIRGLPNTQRNRAISPAKIELLAAQRRMSNSVSQIDSHSNLGTRQRETASENAYEERPTKRTRTIGERVGEAVYNTVIVAGGIGAAAYRYWKGDGSQEKQPYDIPSTSYSPDQSIPGSFNYREAEKEDDYVDIDKPVFSPTSTPTRTPKKKIYRVNSRFRSVQSPKSKPRKQPKDKDEDKDKADDSNNRLDSMSARLSAMIADGQKALVEPAQLDDEDLEDEVLPPSTSFTFTQTLPRQESNYSIGEGLRAAASLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8W5</accession>
    <name>I4Y8W5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_39783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959433.1">
        <property type="nucleotide sequence ID" value="XM_006959371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8W5"/>
    <dbReference type="GeneID" id="18472130"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_39783"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005991_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8W5"/>
    <dbReference type="OMA" id="QVATLIC"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="537"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="810" mass="92146" checksum="1EEE1128E6145739" modified="2012-09-05" version="1">MISLNRLNYMKEISKTLIINLNTIDQPSLKYLLSSHYSPIQELLYNRYFLELFNHFILDDFLDQLLSNLPTSSSILSLTSIIKSSKDTNKISKSKFVLSNLLLKPNGIQSLLQLSLKSDEFNQQKINFLAKMLSTKPTNMIDDTYIELLIKNLLHTTLFDPPTTHLKVISNTIDLLQLKSPSSTNYYLDLHILNPFFQLDNPSAITNALLYIKHLNIHSKLILDNYTNRLLPILFNLAQHLNNSKTVNPDFKLILDEIFASWSTHISKENAVNSIWSTLNSNNGWNDDSLEWSSSNPDGLQIIKKSSSSTNKPNLFNISQHEQNDLFEITPNPQLLATFVINIHRKEISSNILIKCLSQYHGLEDFSNYEMLNIKEILKYLQFSTALIEQMGSTVLDNKDEILGFIYHTLQIQQSSTTNETETLNRPAKGLQDLLIFETQNDTVESDTDEHLQSVDQILISTALSLLLAILEANSHLNVDNTPLLALINQKLDIFIDQFPAISPVANECKLVLLARNVTTSEMMPSNSAYKEQHEIYQQSLKEIQDPSLPVKAHGLDQLRKLVESTASKNLIIPYDQLTLDETLIDGILDVFIQAIKADDSYIYLNAVRGLVIMMDKIGHEIIAELSKRYSINKTSITEIELDQRLRIGEAIIQVFQRLSNALPSYTHLILPQLINVMSNNDFPALLRASSITILSEACSTCIKAIEPYIFEVLDGIRDLLVIESSKSSKDLDNPLDKDTKLVQLKRSALIFLARFFRENRRDRGVYIPSDLKSSIITNVKYISESDNDDLVKHQAMELIDEFGWSNKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y968</accession>
    <name>I4Y968_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macrofage activating glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_6730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959536.1">
        <property type="nucleotide sequence ID" value="XM_006959474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y968"/>
    <dbReference type="STRING" id="671144.I4Y968"/>
    <dbReference type="GeneID" id="18475236"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_6730"/>
    <dbReference type="eggNOG" id="ENOG502QW31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036093_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y968"/>
    <dbReference type="OMA" id="MCQNVYV"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27701" checksum="3D4E75D8A778D1B6" modified="2012-09-05" version="1" fragment="single">VYPTGTMGPTNPMPTMDTAINQGSDARLLSINGPDDFCLFAPQESGPEIGDVEGEVVAWCTKPRNNARLIPDGTITAVHYQKTPAFVQISALGDFTKVNVLSGDAGGELDPHGATGEGNPIGGNVTALVNGQEQSYEEWMSFQSDSMFCARICTNSPYNGWDAATWCQHELDEMGCEYVIPMSYEDGVFDSCDADAGFPPGVYPQDGDNYSTFHQYYEGTYTGGDGLVTSYTVGTTVTPTGPATTPASSNCTPMPSPSHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9H8</accession>
    <name>I4Y9H8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_20230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959311.1">
        <property type="nucleotide sequence ID" value="XM_006959249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9H8"/>
    <dbReference type="FunCoup" id="I4Y9H8">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9H8"/>
    <dbReference type="GeneID" id="18470828"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20230"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y9H8"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697865" description="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="26"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="14">
        <location>
            <begin position="256"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM20620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="446" mass="50343" checksum="0950DB8DC96C401D" modified="2012-09-05" version="1">MLAITIIISLIICVIFIRNKPKSTKNSIAFFHPYCNAGGGGERVLWTAIYGIQQSQPSARIFIYTGDSESKETLLSNVKNKMSIELNKNTIEFIRLRCRSLVDDKSWPYFTLLGQAIGSILLILEAMYRCNGSAVFIDTMGYAFTYPIVRLINWNTRIIAYTHYPTISTDMVSRVEHRYENVTNSQAIASSKLLSRGKLFYYKALIRAYTSCLKVCDVNMANSSWTANHLRKLIKRDVKIVYPPCDTVALREFPLGGRQKTILCVAQFRPEKAHATQIEALKELQESNSVHKNAKLILLGSARNQDDLKRVETLKALAKSLGVESNVQFIVNASFDDLLYNLSTASIGINTMIDEHFGINVVEYMAAGLIPLAHASAGPLLDIIVDYNGERTGYHGRDVKDFAQRIDEIFSLDSNKDLEMRQRARNSVVERLSDKKFNEDFLQVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9R5</accession>
    <name>I4Y9R5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_51953</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959240.1">
        <property type="nucleotide sequence ID" value="XM_006959178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9R5"/>
    <dbReference type="FunCoup" id="I4Y9R5">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9R5"/>
    <dbReference type="GeneID" id="18472571"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51953"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9R5"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="318"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="595"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="810" mass="90553" checksum="1B441F4A9CB02D1A" modified="2012-09-05" version="1">MLLDVKRQFFSRSERVKSLDFHPTEPWVVAGLYNGTVVIYNTITNASVKTFEVTDVPVRCVRFISRKNWFVAGSDDYQLRCFNYNTSEKIAAFEAHPDYIRSLAVHPTQPYVITGSDDMSIKLWNWEKSWRCQQVFQGHTHYIMNIVFNPKDTNSFASACLDRTVKVWSLGSPHANFTLEAHDKGVNYVEYYHGNDKPYIVTTGDDRLVKVWDYHSKSLVQSMEGHTSNVSFAIFHPSLPLIISGAEDGTVKIWNSNTYRLEQTLNYGLERAWSIAYSKSINDVAVGFDEGSVVFKLGREEPTFSMDTSGKVIFARNSEIYGTNLQTIEQSDLVDGQRIPSQARELGSTEVFPQSIEHSPNGRFVTVCGDGEYIIYTALAWRNKAFGLGTSFAWAGDSNTYAVREPSGKLRMFKNFKEKNAPTVANSMGGITNVYGGTLLGVQGPGWILFCDWETGNVVRRIDVDVTNVSWSPAGDVVAIVAEDSVYMLNFNREAYDEFVASGGDLGDEGVEDAFEVVSEITDSVSTCKWLGDCFVYISTTNRLCYVLGEQSQPLNNFDGPQYLLGYISTQNRVYVIDKDLQIRSYALAKSLIEYQLAILTGDHASAEAILPSIPSDQKNRVARFLEEQGLKELAMTVATDTDQKFELAVELGKLDEANELAKETPNVDAQNKWRTLGDKALEGWDINLAVDCYKKANDLEALLLIYTSNASKEGLAELAAIATKNGQHNIAFAALLQLGSPGECVDCLMRTERFAEAALFASTYARDRIQECTMAWKNSLFSDKKDKIAKSIAEPQEQPELFNNLIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Z5</accession>
    <name>I4Y9Z5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_64954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959052.1">
        <property type="nucleotide sequence ID" value="XM_006958990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Z5"/>
    <dbReference type="STRING" id="671144.I4Y9Z5"/>
    <dbReference type="GeneID" id="18474975"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64954"/>
    <dbReference type="eggNOG" id="ENOG502S535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058669_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y9Z5"/>
    <dbReference type="OMA" id="LAWWIEG"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="26396" checksum="D65BBDA53A5FB622" modified="2012-09-05" version="1">MFKTTAPWKTLLEKLLDDNKAISKDIFNVAVGTIENNRPKVRIMVHRGFASESNILLSTTDIRMQKVKQFEANYVKDQGTPLEYVFWIEPAMRQLRIQANAFLLPSPQVKDKYNPTPLPDSLLQTGIDFESERVKIWDEMSDPLRAAFAKPVAPGSDRNSRIDIKEYPKKVQVDKQDKWYNEGLERFTLVIIDPIEVDYCDLKSQPNERKIFRKEADFSWSEKDVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA07</accession>
    <name>I4YA07_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959064.1">
        <property type="nucleotide sequence ID" value="XM_006959002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA07"/>
    <dbReference type="STRING" id="671144.I4YA07"/>
    <dbReference type="GeneID" id="18471609"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33025"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034764_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA07"/>
    <dbReference type="OMA" id="ELWTYPT"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="406" mass="45797" checksum="6E372A776972ABA7" modified="2012-09-05" version="1">MSSNNVKRAAVALILRFRPKDGYRNRSPTSSEDSPSNLNSIDQLFSQPWMQDGAVTPEILFIQRAARNGDRWSGHVACPGGRYEPADDNLKYTAMRECWEEIGLDISDQRQFLCLGQLDDREVTSSLGKKLLMILSPFVFVQTTPSDIKLELEPQEVESVHWIPVDLLTDLAQYTRVEVDLPTRLSPKSNIGRAILSTVLSNSTLSFPAIQLPNKPFLTAPQSGLASVTITEENEQDYAPPTPAELDETITELRKRTADNRINKSDHPTEKLERPPLKLWGLTLGFTLDFLSHIPKTDKLDTGISPESSRHLATAHVIKALFPSFNSPDINIWMWVCGRRYRSIRRQWESAALNPGSADKKKNWSGTIRSAHFAAIRKALIFTVIFRICAAFTTISIFGRYLHKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA34</accession>
    <name>I4YA34_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_54863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959088.1">
        <property type="nucleotide sequence ID" value="XM_006959026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA34"/>
    <dbReference type="STRING" id="671144.I4YA34"/>
    <dbReference type="GeneID" id="18472696"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54863"/>
    <dbReference type="eggNOG" id="ENOG502QSJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_1_0_1"/>
    <dbReference type="InParanoid" id="I4YA34"/>
    <dbReference type="OMA" id="HKYVSQR"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="425" mass="46016" checksum="1FA91BCEF4C40450" modified="2012-09-05" version="1">MIIAFNCGSSSIKFKLFDKDLNTLASGAAKNIGEDPTINISGAASVNETISKDTAYNDIFKALLDKIFKALNIKEDDITATSHRVVHGGNIDKPVVVTSDHSEKLKEIDKISAFAPLHNGSALMSLEAVLEQLPNTPAVIVFDTLFHHTLPQAVRQYAIGKPDHEPRIPLQKYGAHGLSYQSILKIVASKLGKKENETSIVVAHLGSGGSACAIKNGKSVDTTMGLTPLEGLPGGSRTGSIDPTLIFHLVRDVAETLDVNGMRVSRGEYIMNKQGGFVGLCGTSNFGKILDEIPPADHECWKPWYEGDMPNKYALAYALYLDRLTQYLLSYLQKLSHGQDPKNAIDALVFSGGIGEKSVRLRKDVVDRLSVFGVSVVDSLNNQASEQEDEGAFALSNDISKIPAYVCWTDEEGEAARQAKSTLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA53</accession>
    <name>I4YA53_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_33053</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959107.1">
        <property type="nucleotide sequence ID" value="XM_006959045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA53"/>
    <dbReference type="STRING" id="671144.I4YA53"/>
    <dbReference type="GeneID" id="18471614"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33053"/>
    <dbReference type="eggNOG" id="ENOG502QS47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="InParanoid" id="I4YA53"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="510" mass="58556" checksum="7A770A5EE57C98B9" modified="2012-09-05" version="1">MAEPIEKEEVAPVEQTSAPQVDLLNPPPSRFEKPAGVNTTNFPGHANPPLPVEGNGYFSNLQFVALILAVPYILKRFIPFFNTGFKTYVFLLILTGPFTAIAYWTAASTYGPRKNEKVALPGRPIEEYLDIKDPELKQQFHGHNKINYQQFHDAYFEGKIDVKGDMLDVLEYRHDWANFNFTPKLFKYVVFKMIPDILFHSQSQDEDQIQDVYDRGDDFYEWFLGPRMIYTGGMVRDTTRAETLEELQDNKLSMVCEKLDLKKGDRMLDIGCGWGTLAAFAAKNFETDVTGITLSKNQAKFGNDRIAKNGISSEQARILNKDYREIPKHTFNKISCLEMAEHVGIRRYSTFLNEVYNLLDDDGTMVFQVAGLRPHWQYEDLIWGLFMNEHIFPGADASCSLGWVINQLENAGFEVKSIDVLGVHYSVTILRWYNNWLSNKEKVLEKYGERWFRIWTFFLASSVIIARNGGSSVFQITVQKNLNATRRIEGLHSHHAPLHRLKSDYKTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA84</accession>
    <name>I4YA84_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959136.1">
        <property type="nucleotide sequence ID" value="XM_006959074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA84"/>
    <dbReference type="GeneID" id="18474137"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60748"/>
    <dbReference type="HOGENOM" id="CLU_1983296_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA84"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="126" mass="14740" checksum="3D4323AC86BEF2C8" modified="2012-09-05" version="1">MYRLRTDSVWIGPFRVLDKWSTAYRVELRHTRAHNVFHASYLKKADTSRPQQPTSLTTRATLAIDNNRYQREENENFYRRGQVQRLLQQAHTPDGINQPVSDATWVDAEALHEISNFGDVVTRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAD8</accession>
    <name>I4YAD8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAPS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958925.1">
        <property type="nucleotide sequence ID" value="XM_006958863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAD8"/>
    <dbReference type="FunCoup" id="I4YAD8">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAD8"/>
    <dbReference type="GeneID" id="18471589"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32927"/>
    <dbReference type="eggNOG" id="KOG2073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003676_0_1_1"/>
    <dbReference type="InParanoid" id="I4YAD8"/>
    <dbReference type="OMA" id="ECKSHNP"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="911" mass="102475" checksum="19B9CBC4C1763895" modified="2012-09-05" version="1">MYWRLGFGANKEIDQLLDKENVELEEILQEDSIIHESKSHNYRLLEFLVLPQNLRKLLGYSNGKINVVDDQYKLRFPYVATEILSSDIPAIHEALVDKEKRSDYLQPFWDFIINKSTEDLSQLNPFVGYWGRIVARLLDKKSDEMLDFLKSQNDPITSFLKHIETPVIGDLLFRLIVSDQQDSSVVDFFTESDFIPKLSNILSPSFSNDAHLAVADLLKTVITFSAPSPPTANPDNQIYISNNFARQLGSENVIEKLISYILDDIPIDKSLKDGDISTNHLPDVENNDKIASVTSSLISILSVYIELIRKNNADFSEPHLFHTLRNKLINIQQSQQDDILNSENLDESDEQKEEENKLHLEEAMNKMSQSIGIVHLGSILKSFTKRLGDFQTLLAFPRSYKGPIQSSMGPIKPLTFERFRICELYAELLHCSNMGIFNRNTTVGPYYDNYGRLIGGLDALTQLARALSDSEEMEDIPVNSPEDHIEPQQEQLPQSMSNLSLKVDELTLGDSLKKAMIDNGILKTLVDLFFDYPSNPFLHNVVYDVILQILNGQMDRGLSFDLALSLFNDANLIQKLLDGHDKIKQSEINKTIKPGYSGHVMLIADECVKALEKYDNLHQHVKNKIPDEWNEFVQGPLKTTQGIEKEPLGGIKPQQSQYGHFGKVEGDQDDSDSDDDIGFMSSGFGSTYRSLSGQSHTNINFDEDEDEDDSFFNSFSFKSASFGQPSFDEDEIGDDSQLSKYMNRSSLDDDSSNDEDDFGDFASASSYQHFNDDGKEEIDPFGVSKAGSNTENQFLDNFTPKLTNQNLTPADWCREFKDSVDDESTITIPTLDEGDSEINDAIKGLKIDGVSDERNAADELNFDKSAPLGPGLNGPAEITDGSVKREVEGSIMEAPKDDLVLLAEEKAKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAK6</accession>
    <name>I4YAK6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_5928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958898.1">
        <property type="nucleotide sequence ID" value="XM_006958836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAK6"/>
    <dbReference type="STRING" id="671144.I4YAK6"/>
    <dbReference type="GeneID" id="18473265"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_5928"/>
    <dbReference type="eggNOG" id="ENOG502S0I7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056587_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAK6"/>
    <dbReference type="OMA" id="IMFLMEV"/>
    <dbReference type="OrthoDB" id="3005035at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="270" mass="30376" checksum="824DCE5709A8E4A6" modified="2012-09-05" version="1" fragment="single">KRPKPKRPIQPWELFKAIEKKDIMFIMTCRDHSFDLLLRKVGDSTPLVHAMRLGKEYDGIAIVLVGAMSKWVNSMDEHTLKSASNREILKSLRTNLKLAIDHGLSTGQTDLLASYLQTLVMSEGDKFINDATQLVSLALTNPITNKPVQTAASELRKFATWRLDRSASTIASLDDYLSNGIADLVMMAAWLQVLRFYQQGEPIPTYVFARDDRCYKTFVEGLSAASITIKVTASHKLKYHLSAIEKVLGQRHISLKERVSKLSKVLDQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR2</accession>
    <name>I4YAR2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_46913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959040.1">
        <property type="nucleotide sequence ID" value="XM_006958978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR2"/>
    <dbReference type="FunCoup" id="I4YAR2">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAR2"/>
    <dbReference type="GeneID" id="18472405"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46913"/>
    <dbReference type="eggNOG" id="KOG3412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106801_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAR2"/>
    <dbReference type="OMA" id="GKYGQRP"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="137" mass="14890" checksum="B5067F052F51A057" modified="2012-09-05" version="1">MSGDLQWLLLRKSSSFIRPSAPESPLLSSEPGNLIAKHSYKYSSTINGQKALGIKPQEKGALIVARKTKSPINEWNKGFAKTQVTGGKRRAYKSTANVVSTTRPDLLKPSVARVSAIYASQNPKKDAPVKKVRGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAR6</accession>
    <name>I4YAR6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958743.1">
        <property type="nucleotide sequence ID" value="XM_006958681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAR6"/>
    <dbReference type="STRING" id="671144.I4YAR6"/>
    <dbReference type="GeneID" id="18474028"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60558"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2672985_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAR6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="75" mass="8779" checksum="D1AB7124D72E06F5" modified="2012-09-05" version="1">MANQIAWIYPRITVLILHAVRFRDKRLVFLNQLDYGQLVITGLFKVDSVQFRRVNQAYIIFTSNIINVGAVDQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS8</accession>
    <name>I4YAS8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958755.1">
        <property type="nucleotide sequence ID" value="XM_006958693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS8"/>
    <dbReference type="GeneID" id="18475551"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69230"/>
    <dbReference type="HOGENOM" id="CLU_998206_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAS8"/>
    <dbReference type="OMA" id="WNGLRES"/>
    <dbReference type="OrthoDB" id="3353673at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="249" mass="28245" checksum="722DF98C1780C344" modified="2012-09-05" version="1">MVKQLTSVQSLLSLPSNDQPQWYAAGPSTSSVILKNEVAGNQQTAKNPRGNRGRKLSLSNSLNRKGKISRWNPSSRSLEMDRAHRDQVKKRLSRFIPDEIELEYDSDDSDSVSIELDEPSWYDVIPQPQRLVDAVQSPHIKSSITCPRLSEFEHRSADVVENEKEITKSIGRALSNIYDTRNTTNHINELFISNTGVDLPTNNGKEVQDIHLTVEEQKVQAQRHIESLHEALADSREYIEQLKSQFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB47</accession>
    <name>I4YB47_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958861.1">
        <property type="nucleotide sequence ID" value="XM_006958799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB47"/>
    <dbReference type="GeneID" id="18474062"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60622"/>
    <dbReference type="HOGENOM" id="CLU_1222244_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB47"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="25186" checksum="733DC7A15E436133" modified="2012-09-05" version="1" fragment="single">MSKAKKEIESSIRQTRNNTHFLREKKKCGAPRTFLKDILKLANTENSGVAFCCKNACGFKILNEMLKVSLGIIKEAEWGRPLTPRETGKLVPTFQKSCQNYFISTDECVAGACSKRKSAMKDGFEFVNTLYKFPTPFKVDDVASYLAIPNKNVAEKKAPKNAKAVVPSDVTTPKSEKSSECSERMEALSVTTNMSNRRPNKGKKRAEEPSVEGTTCHPQKSPTSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBA4</accession>
    <name>I4YBA4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_32711</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958601.1">
        <property type="nucleotide sequence ID" value="XM_006958539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBA4"/>
    <dbReference type="FunCoup" id="I4YBA4">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBA4"/>
    <dbReference type="GeneID" id="18471545"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32711"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009169_2_0_1"/>
    <dbReference type="InParanoid" id="I4YBA4"/>
    <dbReference type="OMA" id="ANLTMFT"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="390"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM21246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="574" mass="64633" checksum="B6148593F28FB474" modified="2012-09-05" version="1">MTKLILYGLITIASTLGVISSAFRSYSNFYAVAVYLSNSNGASLILGNFALFSGLCIGKIIQKLLFGELRTLETEHLYERSWYGFTEMILAMTMFRDEFDLFYGLMFGFLFFVKVFHWLSHDRMEYMVQYQNASNSIAVRLAIAYAGLLVTDFVLLSICVLDIYLNGVTMIILFASEYAILLADALTGSIRLAINLKDLRSGQAWEDKSLYILYVDIFADFLKLTIYTVFFSVMALSFGLPLNLIRDLVLTTRSFATRIKDLQRYKSASKNMDRLYKAATVEELDALSDKLCIICRDDLIHESLHQGPWPSGLDETPKKLPCSHIFHRHCLKSWLERQQTCPTCRTSVVPNAQNERSDRPNNGNENERPRTEPRREVQPEPATRTQPQPANTNENAQQSNANNSEQSSTNTGSRSTSNQTSQPSPRPSSSTNPFNTIQTHPMSHILNIPNVTLPIIRPESRALPSTYWRDVYRNAHPTTKTDIPSIVTNDGSTESLIAENVPLPPSPSTSEQETDRDIDRKLTSLLEAQSNINKAIGELVGMVKDSNKRERRSSDVGEADNTSSDAETKRARIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD0</accession>
    <name>I4YBD0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_32725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958625.1">
        <property type="nucleotide sequence ID" value="XM_006958563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD0"/>
    <dbReference type="FunCoup" id="I4YBD0">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="GeneID" id="18471548"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32725"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855805_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBD0"/>
    <dbReference type="OMA" id="NTAGAHT"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="79"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="325" mass="37482" checksum="0F012F872AE82F7D" modified="2012-09-05" version="1">MLELIQKYGLTALVLLLVVATSHSFHSLGLHFGYNILYVLLLSLFGFSYYRACVIEPGYIYYTDEESRVHEWERKSDGSRRFCRKCRIYKPDRSHHCSSCNRCVYKMDHHCPWLLNKCVGFYNYKLFLLLLFYGALLCLYAFGMTTYILVESIKLNLSIEPWYAQLEWAFVAIETFTLGFALLGFFIWHCTLVGSNKTTIEALETDRAHRSHSPRYTAPPTSPESISLPPPPPSTALSGWERSKLTQLALLNIFDRGTKKNFIDVLGWDDNARIWGWWVWFIPSRNTTGTHGQPNAFPVEDAQALKVTAIREELNDFWYNTPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBJ4</accession>
    <name>I4YBJ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_69185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958684.1">
        <property type="nucleotide sequence ID" value="XM_006958622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBJ4"/>
    <dbReference type="GeneID" id="18475541"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69185"/>
    <dbReference type="HOGENOM" id="CLU_1679322_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBJ4"/>
    <dbReference type="OMA" id="TASWPLI"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36535:SF1">
        <property type="entry name" value="DUF1772 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36535">
        <property type="entry name" value="YALI0E30327P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17422" checksum="BC1B8D3E81F29584" modified="2012-09-05" version="1">MVNLPSPSVLQAIGTGFAGITVGMTASWPLVWYSVLDKTSNSNKVKLLHESYRRATLFMPPSIILTTASYTLARKHFSLPAVLMFSLIPYTAFVVFPVNKKLFAKENYPEADVDADSTVDSLLSKWMYIHSVRVLLAASSTFFGFVELFKLLKSGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBP7</accession>
    <name>I4YBP7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_57482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958423.1">
        <property type="nucleotide sequence ID" value="XM_006958361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBP7"/>
    <dbReference type="GeneID" id="18472917"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57482"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_1"/>
    <dbReference type="InParanoid" id="I4YBP7"/>
    <dbReference type="OMA" id="QYATGLW"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="147"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="609" mass="64559" checksum="0A3815C2085BDF61" modified="2012-09-05" version="1">MSNNPQTQHLDSAIIEEDDELVHHQTIDLPGKVRRRSSVRTGNSAFAITPTAIATGSRRWSQTTSAGIEENSIDNLPIVSVNAHHEPAIKEEGDSSDSETVIETDATSYKEGTDSPESLSRKPTISSLGISEHKSETSLSSPRGIAIITTCCASQFFDNQWVTSVNIALPMMASDLGIAQESMTWLVAAYTLTFGGFLLLSGALADRYGRKKVFIGGMLWMSVFTVAVGVSKSGIQAIIFRALQGIGAASSVPSAIGVITNYFVGKQRSKAMALFGASGAVGFVIGLVLSGLLSGTIGWRYLFYILAPVLVAISASGFFFFPQDHIETPKPKLDVIGSFVGTAAMILLVFALTQSELSGWKTPMIIVPLILSFVMLAVFHLIEKTVSSPVLPPYLWKQPSFAGIFAAGFTLYSAWASQIYYQTLIAQEVVGLSPLITGVSFIPMGAVGICFSLMVGPIVEKFPIKPVLIIGYICLVAAPFPAAFTPVGGSFWAYVLPTAIIGIIGTSFCHNIGTIALVASVPPQAKSLAGGLINTAFQIGSAVGLSLTSIANQSVKELQLEDTKGTPQATMKGYQAALFLCSGFAFISLTLTTIFTKNGQKADAGVIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBV7</accession>
    <name>I4YBV7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_38416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958479.1">
        <property type="nucleotide sequence ID" value="XM_006958417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBV7"/>
    <dbReference type="FunCoup" id="I4YBV7">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBV7"/>
    <dbReference type="GeneID" id="18472063"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38416"/>
    <dbReference type="eggNOG" id="KOG0127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011608_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBV7"/>
    <dbReference type="OMA" id="AGYVWDV"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
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        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="218"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="417"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
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            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EIM21449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="866" mass="97775" checksum="FC2A4AFC33A4849A" modified="2012-09-05" version="1" fragment="single">MSKEGSSTLFISNLPFSLTNESLLTAFSDVGPVKSAFVVADHETKESKGVGYVTYAMREDAVAASTEMNGKLITGEGNDKRKCRVEWARQRATLKERKEQAKDNELSNVLGEKTQKQRTRKVSTAKDPDAIRTVVLSGLPTGVTQKEIYKKVRKIGNVESVDLKDDDIAHVKFETPSIANKALPKLHAHIFKGKTISAVLLKRLETAVSGKGKVSRRSRLIVRNLNFNITRDDLKATFIPFGDIHSITLPTIEAKDGSLHNKGYGFVWYTFYHDAQKAIDGMNGKSVKIATSEADVAAAGGTKKQRKKIAKDIESRPVAVDWALSKDQWENEQKAEEKDEKAGEKDDEKMEDASDKSDESGSEDEEEEEENEDQSPENSEIDDDEIMEELENESGTEESGDEDDEEEAKAPPLEDGLTLFVRNIPFEATQEDLYDVFRKFGKLRYARVTMDYETERSRGNGFVAFWNMKDAQECLKTAEIVRATTGTNQQDSMKQNPFQTSSILTADPTSKSAQRLTLQGRVLDVIKAVSRDEAVEKKEEGDKIKHKKDKRNVYLIREGVIFPNSPAGSTLSEADQERRMKSFNARRKLLESNPSLYISKTRLSIRQIPLFVTDRVLKRLALHAVKEFEVEVSRGEREALSREELEDMTESEGVKDPKKGYKGRPTAVVQSKIVRQTDRVDSVTGLGRSRGYGFLEMSNHKNALRVLRYANNNNEVTNLMKIWLVEELEQAQKRHTEAIATAKGEKKDEERAKLKSVQERLEKAKGDQLKESRGTLMVEFSIENVQVIKRRAEKAEAIRNRALKRKAAEEDESEEEEEEEEKPQKKSKKDGKPANKKEDENDTEKSKLGNVIGRKRKERKKRKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC42</accession>
    <name>I4YC42_WALMC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="wse:WALSEDRAFT_60482"/>
    <dbReference type="HOGENOM" id="CLU_1273133_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC42"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="23784" checksum="3286504C9B0D0557" modified="2012-09-05" version="1">MRSKCFTDESRDDNVDLPPPLLPTPSNNASITKTRSTTPQVEELERESSVASVDLERKGSLLDRELSLQRGRSLSRQPSSSLKMFANRVVGVSRKSTAVKDKKEMSSKVATNAFEALSGEPSASETQNTTRIEKKSTLVAATPAKKEKHIQVTNSSKAILVADSPVKAPVFGTTMAASDEDFQEDDIIPDTPQKKHKSNDKPQGKRMLLSELNKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCK9</accession>
    <name>I4YCK9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_54511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EIM21701.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006958323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCK9"/>
    <dbReference type="GeneID" id="18472677"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54511"/>
    <dbReference type="HOGENOM" id="CLU_092551_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCK9"/>
    <dbReference type="OMA" id="FWSETEE"/>
    <dbReference type="OrthoDB" id="3361859at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="21289" checksum="F34794D8869CCB99" modified="2012-09-05" version="1">MGMSGYNHRNNSSSSPSSAGRFSHAILSSSPLAPQDAADPKKRLWKERFKSQQLRKIARAKDVDSTRMNSKQLFNLDEVDDEEDDFLGDRIMDKMTESDYNKFLRREERKYDIHVGSDYDPLEFWSDAGEDIPEDLEEMVEIPSEEDDFDDLFNDAELDALYDDYLAKNTQNTSNREDTSMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD56</accession>
    <name>I4YD56_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_57353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958196.1">
        <property type="nucleotide sequence ID" value="XM_006958134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD56"/>
    <dbReference type="STRING" id="671144.I4YD56"/>
    <dbReference type="GeneID" id="18472904"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57353"/>
    <dbReference type="eggNOG" id="KOG2033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381395_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD56"/>
    <dbReference type="OMA" id="CSENTAD"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="692" mass="78261" checksum="0D8BF4299DEA3157" modified="2012-09-05" version="1" fragment="single">MHPIEELKQEIDKRGLIVQAIVGDRYKQVLNVSQSVVHLDKSIEEIQNTIDDIRSLSSRDTPVNSLPSTHIDPIPALVKLVHDSTENIWRLIENEQHLHAAWLYSLAKITHMQLSSTYPDTLNQLVILKSQHESTLQLKPQIVLKAVISLIKQSITFDDARSTLTALILLDSPSYGQSLDKLLTQRTTALTHIQNNPSVELIISQSLQLINETHELVHKLYIQDELSRYIGQCSGNTADITTNTLINQLSGSEIIIHRIPNQLLNYTPYFAPFDKIPNEQVNQTLDKWIASSLDSLKSVLDAQNGLLADINNISDLCPLRAIVEITNIEHVKNFFVSALEERCQVIWKDLHNDYLETTQTKVNKAMNTVTNIPNAKNDPIKNLLAPLPENLDTTTLYTEHVPIVSEMLTVIKNQSTHIHDQIYDFLWAPNTALQSKNLLNTYHEYANGTLTRFLHNLDSTFDKVLQNANTTQRKRQLMVFRHLLEALQKEETIARNIMLNEETQQPVYMDVIKRVNEKWATDVVNDKVEDDSFVWSTSELDADETRWSNSSGGSKIPEGPSRQLIDLLSGIAHDVENISLHLQDNKELLKSMLSQLWERMSRVFDKEETDERAKVRKSFDIAFLNVLCGHSGMEVEMKGDHTEELRAAAFEALKKYQVILGALINAPGIPAAGAGATGRLNPLLRLGQPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDB2</accession>
    <name>I4YDB2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1754-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_63703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957766.1">
        <property type="nucleotide sequence ID" value="XM_006957704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDB2"/>
    <dbReference type="STRING" id="671144.I4YDB2"/>
    <dbReference type="GeneID" id="18474860"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63703"/>
    <dbReference type="eggNOG" id="KOG3410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098435_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDB2"/>
    <dbReference type="OMA" id="QLSEHHD"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="111" mass="12438" checksum="82CD2C93F22C495F" modified="2012-09-05" version="1">MDAYSYKPSKGLKFKGDNAQIKKKKKSKSATTSKEDIVGSTSTTSPPPISTPGLVDTRTESEKKFDKVQRQRLKYKVKDEAKLSHKEKVDQFNKKLDSLTEHNDLPKIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDD6</accession>
    <name>I4YDD6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM21978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957788.1">
        <property type="nucleotide sequence ID" value="XM_006957726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDD6"/>
    <dbReference type="FunCoup" id="I4YDD6">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDD6"/>
    <dbReference type="GeneID" id="18473749"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60112"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_1_1"/>
    <dbReference type="InParanoid" id="I4YDD6"/>
    <dbReference type="OMA" id="NFITHEV"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="22809" checksum="817CBDD6724A35E3" modified="2012-09-05" version="1">MSSRVPLNPLILCGPSGSGKSTLLGKLFKEFPNDFGFSISHTTRQPREGEILGKSYHFVNRDVFQKLIQAGSFIEYATFSNNYYGTSAKAVAEVGLQNRRCILDIDAQGVKIIKDKHQNLQPTFVFLSPPSIDSLARRLVKRGSETEESLRSRLDAAKGEMEYAQTGAFDYVIVNDDIEQAYEKLRKVALGEGTESDILPDNRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDG2</accession>
    <name>I4YDG2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_68496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957813.1">
        <property type="nucleotide sequence ID" value="XM_006957751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDG2"/>
    <dbReference type="STRING" id="671144.I4YDG2"/>
    <dbReference type="GeneID" id="18475410"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68496"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDG2"/>
    <dbReference type="OMA" id="ACEQNGR"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="164"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48324" checksum="AE888FFC5E80FECE" modified="2012-09-05" version="1">MVSSNSFTVGKLDAGMAILIGERASLIEFPSVLLPAGITTGSIVNIAVNRNQQAEKEHAQAFWDLQKTILDTYGIDSPKQPAIRVRNTTQTSVTIEWDELELATSNLRSLDLYRNGQRLSAISNPDNKTYKMSGLSLNTEYSFQLIMRTTAGVYPSETIKVKTHTINDTTGIRVAIGAITDEKLLDSAKSAIEEMGAQYQDKVTIDTTHFVCSKPGPYNLSEYQKAVQHSIPIVQPQWLLACHAEKKMVNISSFYLGGPMPNVKFESRSSNNVTDATPEVNGAEAGPSEQPDKPEQPEQPVEKQDPATQEALNDPEGGPIDGIPPAVEDDEETKQTKNAVRKEIEEAERQATDAAYGHEDEDVAGREGRDDMRTFSFPRVTAVPEEEQRPSSTPPDIRIINEDGQEQIMAEGLADYDYGDGEEIDLNDDDEESVDSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDH8</accession>
    <name>I4YDH8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957828.1">
        <property type="nucleotide sequence ID" value="XM_006957766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDH8"/>
    <dbReference type="GeneID" id="18473760"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60131"/>
    <dbReference type="HOGENOM" id="CLU_1670735_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDH8"/>
    <dbReference type="OMA" id="EMTSGWQ"/>
    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="158" mass="17794" checksum="C82AAD18FC522891" modified="2012-09-05" version="1">MTLEGEEVDFNELQAQISLSLGTIRDMTSSWHNTSSKANNSTKQDDLREWMSRPSRLGLGASVAQTSASEIDVRLQRKLASKGPSVGNKVEEQSEQSEDEESKYRTTTKKTKNTAKKYLDKPHAVKKNVVGVDSNIQLSKKQRKKLNKKLKQQQQQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDH9</accession>
    <name>I4YDH9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957829.1">
        <property type="nucleotide sequence ID" value="XM_006957767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDH9"/>
    <dbReference type="FunCoup" id="I4YDH9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDH9"/>
    <dbReference type="GeneID" id="18473761"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60132"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_1_1"/>
    <dbReference type="InParanoid" id="I4YDH9"/>
    <dbReference type="OMA" id="EYQHINQ"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="51"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="849" mass="93737" checksum="8C59E24C78B61B72" modified="2012-09-05" version="1">MPVLYSAIRDSVELTKRASEGVFQGGMPNEVNASDPLALFVIQASFIIIFTRAIGYLLAKLKQPRVIAEIIGGIILGPSILGQIPNYMDDIFPDDSLPYLNLIGTLGIILFLFIVGMEVDLNVMKRYARSSIAIATTTLVIPLGAGIALGVGLWKEFNENDDVIFSHFILFIGVAIAITAFPVLCRILVEYKLTQTPVGTIALSAGVINDVVGWILLAVIVALVNSNGGIITLYILLVILGWILLLVFVVRPLFYMLARRTGSLDGGGPTQFVTTLALLLVFISSFITDIIGVHPIFGAFLVGLIMPKDGKFNIIVTEKIEDVVMIIFLPIYFGLTGIQTDLSLLNTGTIWGYTVLVIVVAFFSKLASGAVTAKVCRFTFRESLTIGTLMSCKGLVEIIVLNVGLQTAIIDKRVFSIMIFMAIVTTFITTPLALFIYPSKLRPHTAEDGKEGEDEKHRISTGDKGQLQNYLMVMQKMEHVPTMLYFTHLLQSEKHQNHIDALRLVELTERTSDSLRSETQEIKSDPLLGIFTTFAHLRNIAVRPLLSLTLQDNFVNTVSEQGVENDMVIVPWKSNREAVEKEYQAGHQNPIDTILNSQSSSQKYVQFVRKALSQTKSSMAIFLDQTTGETDSWDGTTLFMPFFGGTDDRVALKLVERLCNRSDVNAVVVRMKSELEHTKSNEAMNNLTEYSPHGLPDTIYPEQNTEQVLESETADDLALMECQKKAGTLGIEMKECVSAKPLFEITDIANRIKETSRKEILVVCGRSRNNENHRKELIAVLESEGIHTQASSLAANRFNHLFQVSAPPSPAIQQTMGQEERKTLGELATALSIKLVKNSIIIVQSGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDM4</accession>
    <name>I4YDM4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_37557</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957870.1">
        <property type="nucleotide sequence ID" value="XM_006957808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDM4"/>
    <dbReference type="FunCoup" id="I4YDM4">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDM4"/>
    <dbReference type="GeneID" id="18472023"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37557"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDM4"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="257" mass="28063" checksum="DB6EF1479737E3B0" modified="2012-09-05" version="1">MKTSIFRPCIDLHNGVVKQIVGGTLSNNPDELKTNFVADKTPAEFAKLYKQNGLIGGHVIKLGAGNDDAAKSAVSAWRDGLHVGGGITDQNAAEWIEAGAEKVIVTSYLFPEAKFSLERLKSVSEAVGKDRLVVDVSCRRRDDKWIVAMNKWQTLTDMEVTKDTLSMLSEYCSEFLIHAADVEGLCKGIDEDLVKKLGEWVNIPTTYAGGAKHADDLALVNELSKGKVDLTYGSALDVFGGTQVKFDDLVNWNKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR3</accession>
    <name>I4YDR3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957907.1">
        <property type="nucleotide sequence ID" value="XM_006957845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR3"/>
    <dbReference type="FunCoup" id="I4YDR3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDR3"/>
    <dbReference type="GeneID" id="18473787"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60168"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_0_0_1"/>
    <dbReference type="InParanoid" id="I4YDR3"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="383" mass="44644" checksum="99238C2CA6AC408E" modified="2012-09-05" version="1">MVQSISEAESIGILNLPNQRHKIVAKRGGHFTIMVVGESGLGKSTLINTLFSTELSAKKDYRRRHAKQLDKTTEIEIIKAELEEKQFKVKLTVIDTPGFGDYVNNRDSWSPIIDFVDDQHESYMRQEQQPNRQEKSDMRVHACLYFVRPTGHTLKPLDIEIMKRLGTRVNLVPVIAKADTLTQSDLQSFKKRILEVIEAQGIKIYKPPVESDDEGNQQHVQDLIDSLPFSIIGSTEDVKNSEGKLVKGRQYLWGVAEVENEQHCDFRKLRQLLIRTHMLDLINTTEETHYEYYRQSQMETRKFGEPKPKKLDNPKFKEEEESLRKRFTEQVKLEEGRFRQWEHHLMAERDRLNKDLETSHGQIKSLESELDAIQIGYGRSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR4</accession>
    <name>I4YDR4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957908.1">
        <property type="nucleotide sequence ID" value="XM_006957846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR4"/>
    <dbReference type="FunCoup" id="I4YDR4">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDR4"/>
    <dbReference type="GeneID" id="18473788"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60169"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="InParanoid" id="I4YDR4"/>
    <dbReference type="OMA" id="VWMLINC"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="329" mass="36692" checksum="197C213027007D6A" modified="2012-09-05" version="1">MNKISINGPLLSIISYCFASISMTIINKYIVSGEHFNMNLLLLSIQSIVCILTVYILKLSGFINYKDFNLVDIKNWFPVSFSLVLVIYTGSKALQFLSIPIYTIFKNLTIILIAYGELLWFNNKITRLTSFAFLLMVLSSVVAAYDDFDLNDLFNKSMIGYFWMALNCLSSAAYVLLMRKRIKLTGFKDWDSMAFNNALSIPLLIVSSLIIEDWSFDSLEKNFPPSNRYLLLSTIAFSGAAAVGISYTTAWCVRTTSSTTYSMVGALNKLPVAASGLIFFNDPATVKSVSAIILGFIAGIIYAIAKQKQSKSNIESKESIIPLNIKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE05</accession>
    <name>I4YE05_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957992.1">
        <property type="nucleotide sequence ID" value="XM_006957930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE05"/>
    <dbReference type="FunCoup" id="I4YE05">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE05"/>
    <dbReference type="GeneID" id="18473810"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60201"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001839_5_1_1"/>
    <dbReference type="InParanoid" id="I4YE05"/>
    <dbReference type="OMA" id="ANVHENT"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="101"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="323"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="668" mass="75158" checksum="CB121239E232031F" modified="2012-09-05" version="1">MTAVHLKGNALDCDTNVDFDNDLLTFSIGLTIATPAIQFVSLEGIKLTVGCRNLVKYTLSFSSQSISKEYFSSLKRSSQELAALSIYDLPAFKSYKGRSSGWSIYNPTDEFRRQGVLDNPAWRTTSINKSYTLCPTYPSLLVVPTKISDNVLNYAARYRSRQRLPVLTYHHWNNRATITRCAQPLVGLTNNRSIQDEKLVEALFTSHLGDTKAHGATATNIIVDARPTTNAMAQRAQGAGTENMDNYPGCQKVYLGIENIHVVRDAYTRVVDAVGFGNTPGGQVDRVAVGRSGYLKHIAVILSGTLLTVRNIHVHSSHVLVHCSDGWDRTSQVAALAQICLDPYFRTLRGLIVLIEKDFLAFGHKFNERCGHTVVERPFYVDGVKEPPPERTFGSRLKEVSPVFLQFLDCLWQLIRQNPGRFEYNEDLLRVLLEKVYSCDIGSFLVDSERERMMVDPLDGQHRVPVVEATESVWDEILTNMSKYTNEDYSEDDKVEDMGVLYPRVDDILWWNAVFGQGTDLNSEIEPETTPQIIDNAKGKGKPYFDTLDSFFGKKESVLGRWGGMAGVARGIGTQVQNFGQGLVHEYNNFETRFGGLRIDDQKDLPPRLRSDYDSSTLFDEGEDTRDIQQNRHEIAQESVQNKESTKETNKPIKETNKEKDPLGVAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE14</accession>
    <name>I4YE14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_28433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958001.1">
        <property type="nucleotide sequence ID" value="XM_006957939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE14"/>
    <dbReference type="FunCoup" id="I4YE14">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE14"/>
    <dbReference type="GeneID" id="18471043"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28433"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420395_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE14"/>
    <dbReference type="OMA" id="NFYISFC"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="709" mass="81453" checksum="7D2D9892DD7DEFEB" modified="2012-09-05" version="1">MASDLSKKQKVARACDSCRRKKTRCDGVFPNKCSNCKDNCTYNDTEPKKMYKVSYVEELKATLAQCQALLDNSSVSHNTDDSLKRKHSISTSDNSRTTDIIPSTDYCDLYDEELARNINGLYIPSDDVRTGNRNFGKASMRGLFERITFYTGMASDALTHQRRFDFWVEDWEKELSSNLDSHNTDYTDEDFGSDEVLYHLVDVYFRMVNVTLPLLNETRFKANIPSRKLEKEFGSVLLMVCALGAIFSGDKSFVIAEKEHLQFLAGFDYYKVARKKMKDFFITPATLEDVQALILLQVYVDQGVHTKSSWMIHGMSILLARNMGLQHSLLNKHKEPLEAEASKRALWIAYIIDRSHSSCFGKPLLLKDEDIYLELPQPYGNEDAHGNMGVFYMSEMIKLCKIHGQVMQKVYKYRKSIDCDDHVLTMTDIASLHSKLHAWLDQMPDFLHICKDDNETDFIMQLRSNLRLAYYTIQIFMYKPFLPNPTLRNPSNFQFTSLLICANASRSIIGNCKEVVLKRNLNKIYVDSMMDWGPFWATLILIIRCCESRRLTGHVDKDDVCYVKSGILVLRVNERKNVQYGRAIDVLLQVLKAVKLPDCEDFIRMEEYISYQSTNEVRHNCLSNRTLSAVKSEDANQQVLAEQDYQLFGDMLEYMQNTDAMKDNLFSVDNLNFMSDAPNNLVNDSDFDWSKIISPLLDSNTESGTDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE35</accession>
    <name>I4YE35_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_28027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957492.1">
        <property type="nucleotide sequence ID" value="XM_006957430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE35"/>
    <dbReference type="GeneID" id="18471022"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28027"/>
    <dbReference type="HOGENOM" id="CLU_657574_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE35"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="418" mass="47691" checksum="B3FB1BC09E9BC40E" modified="2012-09-05" version="1">MAAGSRPTERDIETGQTIEYTRWHKIVEKFLHLLFPFIRLSEEHFSELRSDFQDGYIEYPGDKYNTIKPTYVLTYALFVWLLRGMTMKLTTESEEINVQPITDLPYCLIELDMEQLTPKHPLTEDILKDFANRNIQGTCFLFHVTNATVTRLRKENDKLYEHFTHRRYNNYGDHEHNMPKLLFMALKEELAGVRYLVGEEISYKPHQASVQVFSMGTFTLMYFRFCQGAALMTSLVLTAIAGILPVWDENKQIKIASVVLAGCGGALAIIQFITTRSFELTYGIDPKAALADNPIFVRTDLGVMPGETVRSWKAEQVRLLKFLVIHQVYTVKGRAYCVFRALNASGPVSASCNLGVTPYALMNALPTFFSDKGSRKLAALPDPYSERYWEAGKSHIHSNTVNSASASLYHHSQFRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE50</accession>
    <name>I4YE50_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957506.1">
        <property type="nucleotide sequence ID" value="XM_006957444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE50"/>
    <dbReference type="GeneID" id="18473654"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59964"/>
    <dbReference type="HOGENOM" id="CLU_487628_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE50"/>
    <dbReference type="OMA" id="PHNIQTH"/>
    <dbReference type="OrthoDB" id="10557875at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="559" mass="61978" checksum="3E7D17D28DB11502" modified="2012-09-05" version="1">MGANQSITQKISNTFSTENSRKRSHSQSEDSHIDDTKNKKLKSEEKEEAIPTSDREDGEISEPEDAKPSTKVILQQRLEALKNEMQQQASRESTPPVQSAPAVRYHYHTPLPAVPFTDYDVHLVRNGLMNGLGYDFLLSQGVARNLLDYAQSLIPSTSSTLPVVRPSPTNINAYPIPTSPTITQVKPRKPKKGVNLEIYNQNEELFKRDPKSLTKAERKERKKIAKMHKKHLKDDAEEVEREVAPKKAASTADDFLNSLSLGQNETFNGGSATSASLVEPPSQTFKVSQKPHLKRHQRQSPFLKAKSSEVVIVPSDEECETNSDIESASIGSAREVEQIPDWVIGKTIPKPSIVSNNSNATLTLKAKAAQGDVQAQNELKRKQQEISEMQLKIKQMELKREKQKLEALLMERQKSDNNGAGVAAAKKAVEEKKELVEEEKEKVEGEKRHEENVEEKQIDERNSNNVNEKAVEKAVTAEVAGSDMGVAPIDATHDNAPHGAPNAGDTDAAQTSDDTTGQKDMLLGSTLQAEEPLDGGKTKVFLKRIHHYYSTLMALMMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE75</accession>
    <name>I4YE75_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_50827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957530.1">
        <property type="nucleotide sequence ID" value="XM_006957468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE75"/>
    <dbReference type="GeneID" id="18472536"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50827"/>
    <dbReference type="HOGENOM" id="CLU_2814381_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE75"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="67" mass="7445" checksum="ABF3C1A3AB256F66" modified="2012-09-05" version="1">MGRKSSEISSQDVFPRHSNRTSLNFADDTPVCNEWTISLLESRDVTHQVGLAAINNNTGRITLTQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF8</accession>
    <name>I4YEF8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_60030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957605.1">
        <property type="nucleotide sequence ID" value="XM_006957543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF8"/>
    <dbReference type="FunCoup" id="I4YEF8">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEF8"/>
    <dbReference type="GeneID" id="18473695"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60030"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEF8"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="203"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM22350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31584" checksum="0B0231A95B91FC09" modified="2012-09-05" version="1">MSSYGPKRDVNASGWEESEFPILCDDCLGPNPFVRMQKRAFGKECKICMRPFTLFSWCPGAGTRYKKTEICNTCAKMKHCCQTCILDLTYKIPVHLRDAALGMQSKAPTENLNRQYFAQNNEEQLKGNSTMVDGGLGRAENAGKQILRDLAKKEPYYKPTKEQKSSNKPKEIKSMPLTSTQSVAAAPKMIKLDLKPPLDTEVISLYCSQLPDDTTEDELKSAFGDASPSIQSATIVPTSKVSFVNFASRQAAEIAALVISKKGLIVRNEAVSVKWGRSKKKPATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEG0</accession>
    <name>I4YEG0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication protein A, subunit RPA32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957607.1">
        <property type="nucleotide sequence ID" value="XM_006957545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEG0"/>
    <dbReference type="FunCoup" id="I4YEG0">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEG0"/>
    <dbReference type="GeneID" id="18473697"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60032"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="InParanoid" id="I4YEG0"/>
    <dbReference type="OMA" id="TFHFIDC"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="272" mass="30068" checksum="BB8F2AACC9A13863" modified="2012-09-05" version="1">MSYGAYDESNPYYNDNNGSGGFLTNSQGGGYTDSSPSTRNKNEDTLRPVTIKQVLGASQPHSDFPFQIEGRDITHVSIVAVVRSASKQATSAVYSLEDGTGTLDVRYWMDSSGGESESTTDIQQNQYVRVIGALKSFHDKLQITAQVVKPITDFHEIFYHKAEALAVTLQIRKGTDTIMNESKPSATYGQESTSEPNYMRPYLTFPELHKSVMKAVFEEVDRSPQGVHVARIAQRCPKGDEALTEAIEYLISEGHLFTGEDDEHILPVSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEH0</accession>
    <name>I4YEH0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_60038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957616.1">
        <property type="nucleotide sequence ID" value="XM_006957554.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YEH0">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEH0"/>
    <dbReference type="GeneID" id="18473701"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60038"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000684_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEH0"/>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Adaptor protein ClpS core" evidence="4">
        <location>
            <begin position="90"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="6">
        <location>
            <begin position="660"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="5">
        <location>
            <begin position="1198"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1663" mass="189421" checksum="F89A7EE840CC22CC" modified="2012-09-05" version="1">MTAGGCCDCGDPEAWRIDPGRPSHLDEPDTIQVDLPEEALERARQYISTILRFIIDTIAHSPSEFTPPNNVPKVKSLATSKPNTPTDAGPWSVVLWNDERHSFDEVIEQVSLAIDCYHSVSRSVAERIDKHGREVLRSSTDINALLKIAVIINSIDLAVTIRPSYDTNLEDICHLLLEFLFDLCHSRPQELRSIVAEELLKLTTSPFTEHISKDRRQMTNLQCLLLLESRMWKKARKIFRDMLVAMLGVNQDVRCQIGLQFALVYKNLVESYLLQDHEPELSSLMFSIQVFTTPSVASLICFNSEFHANSLLTTILHLIYAFLTEQRTSPKQIKLIDTIGNNVIDCESTSIRHKRYLTIVQDLKTLLTNEAVIDELPKRIDLLDDFVKFFIPFTDMNQFQRAVHEHVEYESDAWINAFNCTIQLTKVTNALGDLSYNFTPQQLFTLIKHILDGIAETIHRPNFFTKLTSIQFGGYSYNVVDYSVAYEPVSFHHPLHWWLGNVLKHVKILGHFYPGGVNTRELPLVFGERARNNLLPVIALFEQPMRVCAFVAQARCGLWVRNGFSVRGQVHHYREITFRDNTYDLDLFNVQVMFTIVDPEQALVSLMTKFDMLTWFEGYIYHSVYDEKQTPAMAEEFILLLIACLTEPSNIAGWPKEKRIERSLIHALCFGPSTYSEFTRIVSDTLVDDPSFDRILEKVAKYKSPDGTADYGTYELKDEYYKFVDPFFMNFTRNMRESAANSLNKYYKRIGKEGATHIPEKLDLPDNGPYNSLIGVYKTEVFQQIVYASLFNAFNERDEQGRPATSFTRDILIEAALHLMMCALVEAKVIFAKLAGSRTYLMHSTLVELLCKYENDQRLINVKSRITWILDQLADVCGDVVGANRVVNEHKKDEKAEDHAESQKAAAKARQAAIMEKFANQQKSLLDQLGDEDDDMDDEDYDSKVEENIDGPNADTRDFGDCIVCQETLNGTSFGSLAFIQPSKMLRNTPSLDPNFVYDPLWMSDSLDRQQQSNMSEEYKQQFIQSKSNTRAGNSGITTQGFPSDQTRLGLHMSTCGHRMHMSCFETYFASSVSRHQSQIARTQPDEPKWKEFVCPLCKGLGNVVMPIFKRPESATNNVKITEWVRSASIDLLKDPKVSLLNDFQEQETGSGEFWPWYVRSAPSKSGSLEEDPKSALTDRLMALIKPISTNAEDLRQSSVPAAQELSSEGMYLPGELVAYTISSIEVALRGIDSQDKLVADQVNDSQLLMIESMLGCLENLATRHPTHSTNGPQIIAKGIFQRILPEFGREDNVRQPLLLRDPFSLLVETAAIAPESLSPMITLTFYAQLVRTVIALIQASRTDGVADSPLLRPPTEIEKLPDNAEQIFGNISSVIHYMLQSFTALYNDGERMLKLLPNEHLSKLMYSYMLPFLRRVSILNKVVRKAPYVFTKRSNDNDTKMHLYDDDNQCEFRRLMTELDILPPNEALNQSSERQTTIQRMVEGWCSHFGHHVQELRPRDYALKLDYPEVYKLTNLPYQLSALIDDVLTRVCPNCNQVPPDPALCLLCGASLCHQSFCCHDQLTKVGECNTHMKKCGGIVGAFFMPKKSATFYLYDLRGSFAQPPYLDAHGEVDIGIRRGKPQYLHKQRLDEIYRIWVNHQIPSWIGRKLDLVSDQGGWRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEU6</accession>
    <name>I4YEU6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tom7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_68435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957728.1">
        <property type="nucleotide sequence ID" value="XM_006957666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEU6"/>
    <dbReference type="FunCoup" id="I4YEU6">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEU6"/>
    <dbReference type="GeneID" id="18475400"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68435"/>
    <dbReference type="eggNOG" id="KOG4449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173610_1_1_1"/>
    <dbReference type="InParanoid" id="I4YEU6"/>
    <dbReference type="OMA" id="FILYLGW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="51" mass="5621" checksum="54F3C7A6D6B64483" modified="2012-09-05" version="1">MLSDDNKERVTKAVEVAKVAAHWGWVPFVIYVGFVNANPKPSLIKLLSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF07</accession>
    <name>I4YF07_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_59822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957219.1">
        <property type="nucleotide sequence ID" value="XM_006957157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF07"/>
    <dbReference type="FunCoup" id="I4YF07">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF07"/>
    <dbReference type="GeneID" id="18473568"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59822"/>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017627_4_1_1"/>
    <dbReference type="InParanoid" id="I4YF07"/>
    <dbReference type="OMA" id="AFVCYSW"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="450" mass="49475" checksum="154886F299CAE07B" modified="2012-09-05" version="1">MIISGGILRNGGFSCFRATIRTPPLRSSKQLKQFKLQSSLSLRSMSTPAQLPKITQPAVSKWLYSISALIAGIVVVGGMTRLTESGLSITEWKPITGIALPRGDEWIVEFDKYKQTPEFKMLNSRIDLEDFKKIYMMEWAHRIFGRAIGVAFILPAGYFIARKQISRGMKWAVGGLGLGLGFQGFLGWYMVESGLKEENFAHVGAHPRVSQYRLSAHLGAALALYVATLYAAFAAARDFRVGRGGSVSGVSDPEKFLGNGATSSLRRFRVIARTGLGVVFLTALSGAFVAGLDAGLIYNEFPWMGTGITPPKAELWDPRYSQREDRSDLWWRNMLENPSTVQLDHRIMATTTLIGTLAMHALALRSPTMRKNLPPLTKKLLNLTTGVSLMQVTLGISTLLYLVPTPLAVSHQAGSVALLSSYVALVASLRRPGLAARMHQRFMQQQKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF30</accession>
    <name>I4YF30_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_56772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957242.1">
        <property type="nucleotide sequence ID" value="XM_006957180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF30"/>
    <dbReference type="GeneID" id="18472849"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56772"/>
    <dbReference type="HOGENOM" id="CLU_1548817_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF30"/>
    <dbReference type="OMA" id="HISTTIY"/>
    <dbReference type="OrthoDB" id="3348088at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="173" mass="19828" checksum="7B2461229475392F" modified="2012-09-05" version="1">MDMDTYQWPVSTNMKLTDSATFIINLNNLPKYISKTVNPTFDIHLTILRNLTGSTIAIITSKDFENGSTEIEVTPISVKAEFSIHDNQSNAYINNNNYYWVDNTFYNQHKHQLGVLEKTDDCISISLLTTLDENIKQLAILLLLSSVIYQERSTRTKKFKWPTIKHKPLAKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFF9</accession>
    <name>I4YFF9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957364.1">
        <property type="nucleotide sequence ID" value="XM_006957302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFF9"/>
    <dbReference type="FunCoup" id="I4YFF9">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFF9"/>
    <dbReference type="GeneID" id="18473614"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59898"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="InParanoid" id="I4YFF9"/>
    <dbReference type="OMA" id="SYFVRWV"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="714" mass="81799" checksum="7795F3A9A42DE3F9" modified="2012-09-05" version="1">MSRLSHSRTSIISEQNNGRIILEGYLLKKKQKKMQGFARRYFRLYSSGTLTYAVTDTDNVRDHVNLRSSVWLSHNNRRTVTIDGGTSTWHIKFTSGEEYVNWMKTLRIFLDPTPTAVPLETVAENAQRPPIENINKSIKLIDLIEFDLTNLKNGQNQVRTPPSSRSREQLHASSSHQGGLLNIFHKSPKLNSSSDDLFDTQPHRAYDAIFERLLDSTNDLKRLQQELHNMHNTQDFDTVNSRTFNNASRYAPSRTSSVNDFEFYDAQDTFGEAYEFEDPDEEDEGNDDVHDDEEDVDKEAIYDGVESSHGPHDSKYGLMQLPRRPQLPAPISGDEIGLLGVLKKNVGKDLTTISFPVSFNEPLSLLQKVAEDFEYVDLINKAIQSKSSVEKMACIAAFCVSSYSCTQYRSTRKPFNPLLGETYEYITPQFAFFSEKVTHHPPLVAAYAQGDGWSFVATSGVKQKFWGKSMEIIPIGTAKLTLKSTGDVYTWRKPSSFIRNLVMSSPYLEHTGDLDIKNETTGETSTIAFKEGSFFGGEASRGFVEGFIDDKDKKRICKLSGRWSQNFVRHLLDDDGKSTDRFQKLWESNNQFPPDCQDYYGFSKHAVKLNELVNEKVLPPTDTRFRPDQRSLEEGDANTADNYKNTLEQSQRERRNQIKGYDQSRVRWFKKINNDEWVPIINEKTNEPVYFEKRARVSDNQDSWSDNDNIFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFQ0</accession>
    <name>I4YFQ0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GCY-3</name>
        <name evidence="6" type="ORF">WALSEDRAFT_31942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957446.1">
        <property type="nucleotide sequence ID" value="XM_006957384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFQ0"/>
    <dbReference type="STRING" id="671144.I4YFQ0"/>
    <dbReference type="GeneID" id="18471397"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31942"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFQ0"/>
    <dbReference type="OMA" id="NEVECHI"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="351" mass="38628" checksum="E2360157A731BCB7" modified="2012-09-05" version="1">MPLQTERIPFANAPATAADTKSDGIPRLGYGCWNLPNEQAADLVYGALEAGYRHIDSAAIYGNEKEVGEGINRWLKATGTPRSEIFVTSKLWLNSKRAENVARGLTKTLDDLKLEYLDLYLIHWPGSLEAGQNFDGSAAIPQDDKGFPIRDYGADEEDTWAALEAQIPQKVKNIGIANYTKSEIEDLLKYAKIKPSSLQVECHVYLQQKDLVAFAQSKGIQVTAYSPFGGLNPTYGGTTEVVSDPLVQSLATKHNTTPHGIVLSFLISRNIVPIPKSVTKYKENFDSIVKLDADDVKALEGADKGKRYNDCSEMLGYIFFKDEKSSEQILTQIAKAGLTRAQAKVEHLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFQ1</accession>
    <name>I4YFQ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Gcy1p</name>
        <name evidence="8" type="ORF">WALSEDRAFT_68213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957447.1">
        <property type="nucleotide sequence ID" value="XM_006957385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFQ1"/>
    <dbReference type="FunCoup" id="I4YFQ1">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFQ1"/>
    <dbReference type="GeneID" id="18475364"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68213"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFQ1"/>
    <dbReference type="OMA" id="ITQYSPF"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="336" mass="38057" checksum="D27C332363AC43F1" modified="2012-09-05" version="1">MMLSNIKKTLNNDIEIPLLQLGTWELGDRTADAVYEALKSGYRGIDCASIYFNEKEVGKGIQRFLNETSTPRSDIFVLSKLYNNSHRREDVEKALDVTLSDLQLDYLDGYIIHWPAAFKQSPDNRAHIPQDEDGVIINDDVPYRETYEAMEDLLETKKVRSIGVSNLTVDQLKDVLSYARVKPAILQVEIHPRLPQNNLVEFAQSYNITVEGYSPFGNANVLYKQEEQLLEDAVLKKIAVKHNVTPSSIITSWVISRGIVTLPRSSNVEHIVANQQQVKLDSEDFAKISALANNTRYCDLSELCGVIFFADEKSPSQIEYQSKESVRERVKKAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFU5</accession>
    <name>I4YFU5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956889.1">
        <property type="nucleotide sequence ID" value="XM_006956827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFU5"/>
    <dbReference type="GeneID" id="18473474"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59643"/>
    <dbReference type="HOGENOM" id="CLU_776600_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFU5"/>
    <dbReference type="OMA" id="ASAYKHE"/>
    <dbReference type="OrthoDB" id="3361700at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35989" checksum="5582789A3E353C49" modified="2012-09-05" version="1">MFNSPLTFNDLSRSTNSQNQQSTMAGQTSNQEGTSYLPGYLSSAARGSNIPLSTPPRQSQSGQPPQSSLSRSPLSTSQSSAHQGHSQSVSGGAFGAGSLFGSISTPLSKSPRSSLYGRPIEDDQEAPPTTFLQDEENVYQQNTTTSAPSAQQIHNLTPWHHAPQPVRQQSPIESRSVTFYGMNDAIRARMMDIFIPQFGAIENVSDGINWIDVVFVDSLAAQRALKLSGKRVDELGGIMLGVKLTHQSDDQQSGFQGQQQQQFDNSKHLTPLPPSQAFKPSPKPQSSTTTLRTMFNTPNKSTNEYGITPEQADSQPNRQTIGGKIADLIFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG00</accession>
    <name>I4YG00_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL46 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956940.1">
        <property type="nucleotide sequence ID" value="XM_006956878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG00"/>
    <dbReference type="FunCoup" id="I4YG00">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG00"/>
    <dbReference type="GeneID" id="18473489"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59670"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1379094_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG00"/>
    <dbReference type="OMA" id="PLATEYY"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="198" mass="23202" checksum="A7A2D824D729612F" modified="2012-09-05" version="1">MKSSLLIIRPAYLNFNSEFKTQYFKYQRDLHQALSGNFNKDFYYQPQSLSQRGFIQREHQKQLDKWGYSIYKDQQLSSQNEISVDENTREIDDSVKNIERRGERSLVLVDEKNAIPTTTVNPKESLDQAALRAGYEKFGRDIDLWLVSKLPIGVNRVDNIDTYTFMSYILNGKPNSPANYLTKEETSENYFVDLIPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG25</accession>
    <name>I4YG25_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_56594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956963.1">
        <property type="nucleotide sequence ID" value="XM_006956901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG25"/>
    <dbReference type="STRING" id="671144.I4YG25"/>
    <dbReference type="GeneID" id="18472829"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56594"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025145_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG25"/>
    <dbReference type="OMA" id="PISTEYY"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="350" mass="39266" checksum="608899B5A650C8F3" modified="2012-09-05" version="1">MNCYDLLNVKVDATDAEIKKAYRKLALTSHPDKNIGDPDAEEKFKKLSEAYQVLSNAESRKKYDDNGYRLEETDQSFADPEKLFSALFGGGKFVDLVGEISIGQEMQEALREQAEFESPEEKTSSSQTKIAKAQLRAIEREKRVERLLNNLIMKLSIHTEALDSPEVDASFRALSEIEAVTLSKESYGFEMLQALGSVYVNKSRAWLSSNNIDWRSGWGIGGWVQNAKGQYQVFSESISTLNAAIELKKAFDALANADKDEVTLDERKALEDDAADKGLKAIFKGTSLEIQSVVREVCDKLLSNTDIDTLQRRAKALLILGEAFTGITRHKNIKTDEYEYLTPQQQRING</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG63</accession>
    <name>I4YG63_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair and recombination protein RAD54B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_67840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957000.1">
        <property type="nucleotide sequence ID" value="XM_006956938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG63"/>
    <dbReference type="STRING" id="671144.I4YG63"/>
    <dbReference type="GeneID" id="18475308"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67840"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_1_1"/>
    <dbReference type="InParanoid" id="I4YG63"/>
    <dbReference type="OMA" id="KCQTHEL"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="239"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="566"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="851"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="102642" checksum="6A2C8FD528761B19" modified="2012-09-05" version="1">MKRSRDSSFKSPAINQISNKNVEASTSSQCWSVQWRNPQFKKHKTWDGDGTLTIRGNQLILKDTNSSVIGRSFDKKNNQYESGAQFVIGGKDVELDQLLDSDTKENAPLQTKGVPTASFYTSVAASAKPYKPPTINRTLESTSKPASSHLEHDNLNQHSVTTSSSLAVTNPRVIPTPISKFDPNAPDALVMPPISTYVANKLNPKQFPLVDVVLDPHISSKLRPHQREGVKFMYEAVMGMRGHKGNGCILADEMGLGKTLQVIALIWTLLKQNPVTNSGPVIGKAMIVCPVSLVNNWKKEFSKWIGQSKIGIFVGDKDVTEIKKFQQSRIHQVLIIGYEKLRTAAEVLKFCQPQIGLIVCDEGHRLKSSNKTSQVFEAFPTRRRIILSGTPIQNDLGEYYCMTEFCNPGLLDTYASFKKKYETPIMRSRAPNCSKGDLEIGRQRSEGLSALNDQFVLRRTADILVNVLPPKTEFVVFIAPTKLQLRLYQQLVQTSIVQKVLDKLSGQHLALIGILRNLCNSPGILYNIMQNNSTDTHKEFKFDSCKELFPVNVNPNDFNLSGKLKALGRLLKTLKNQTEEKVIVVSNFTTTLNLIETHCRVNKYKFCRLDGSTQQAKRQEIVDSFNRSPQAGKFIFLLSTKSGGVGLNLIGASRLILFESDWNPSNDLQAMARIHRDGQTRPVFIYRFLTTGTIDEKIFQRQLTKIGLSNSLMGNTVEKKNETDSFTIEELRALFKVDDDTICGTHDLLDCSCNVESPSAITEVENNDENEPQGFISASQHQTKLFGASKRDRQAKLAALEGWNHIDCLQETQLESLADDVLKKLTIYNETKEAISNNDANDTKNAAYASHSYESAEDFCPASDEEEEEEEDDEPKPKLQKIEHQWTDFSMNDFIGDENNEGRVTYLFKKVSGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG76</accession>
    <name>I4YG76_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HbrB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_43859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957010.1">
        <property type="nucleotide sequence ID" value="XM_006956948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG76"/>
    <dbReference type="STRING" id="671144.I4YG76"/>
    <dbReference type="GeneID" id="18472307"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43859"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026732_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG76"/>
    <dbReference type="OMA" id="SHTIHHS"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="520" mass="57280" checksum="8926A92D9FAFF0E0" modified="2012-09-05" version="1">MITPIEDLNTLVILHIKDTIARSKPSRVIESLSSDFNALISNGMLTLRAKLSQHVDEGSERLATRLTEIWTFFFGQVLPLLEGVFLPYSTDDHIQALSKSSTVNSVKANEGSNHNHSYSIDSDNLKSKHSTAASVMNVRKSVLRGFRDQLIIPLFSSLEKLFLDLCDDVIPATPTSGGLQSKQSLSSLKSAHQAIPDSLPSTAAAIAASSSQPTTSAFSPVPRLQQMTLVLSSIRAFDNAQDNVERLARILRRCYVDDVQDQPTSSSAGSLLFRSTQTSMSMSPFAERLLGKRRDRRGWIRKKSSNANASSTDDHLDDVGGGLYELSLEREPTQRDSEDEWLDTLRSPNVSPAYVSTPTTNTHATEKQRNKPPPIIAPRGSSLAFAGNADDASSSDEDDLSVEFRPVDELPRVSTQPDLSRVNEDDSNDSEGAEYLGQRLMGEGSRSSEEKTQETVVQLARSPVEDSLKRWERAQKELEEMLGMNDEPTPTLNSDHRFSKPLPPSPKLVGLDLESEPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGC8</accession>
    <name>I4YGC8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_59733</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957059.1">
        <property type="nucleotide sequence ID" value="XM_006956997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGC8"/>
    <dbReference type="FunCoup" id="I4YGC8">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGC8"/>
    <dbReference type="GeneID" id="18473523"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59733"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_3_2_1"/>
    <dbReference type="InParanoid" id="I4YGC8"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="400"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="717"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="860"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="818"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM23020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="890" mass="99341" checksum="F8B47CCE0B3C4BBA" modified="2012-09-05" version="1">MQDLSIKEHNMEDDEAGEESNARRRAKRNPQDPAEVPKVKDATGEKVMESFENFLESYTEIVDLAPTPGPDGMQTEAESKFYIEQIHGMREYNFTTLYVSFSHLLEREDILARAITDQYYRFLPFLKRAVQNLVHKYEPGYLYSNASAVTGTQSASSYIIREFQIAFYDLPIVSGIRDLRTDKVGTLMSIGGTVTRTSEVRPELVSGCFACEECGVVMHEIEQQFKFTEPSMCPNPTCNNKNAWRLIIEQSKFSDWQKVRIQENANEIPTGSMPRSLDVILRGETVEKAKAGDKCVFTGTFIVVPDVSQLGIPGATTELMREATGRNENQGVSGLKALGVRDLQYKTAYLACMVQSADGRASATNVRADYEEEEDQDTFLRSLTQQEIEELRAMVNTENIYHRLVKSVAPTVFGHDIVKKGLLLQLMGGVHKRTHEGIHLRGDINICVVGDPSTSKSQFLKYVTSFLPRAVYTSGKASSAAGLTAAVVKDEETGEFTIEAGALMLADNGICAIDEFDKMDIADQVAIHEAMEQQTLSIAKAGLQATLNARTSILAAANPIGGRYNRKATLRQNVAMSAPIMSRFDLFFVVLDECNENVDDMLARHIVNIHRFRDEALEPEFNTEQLQRFIRYSRTFQPRMTPEASDLLVEKYRILRQDDAQGVGRNSYRITVRQLESMIRLSEAIARANCSNEILPQYVKEAYLLLRQSIIHVEQDDVGLDDDDEQSVDPLAMDNNTQHPSSSTDPNLKIPSSSMHPSSSADGQPDGTASGQTPQPSAEKSKLTITYDKYMSLMSLVVQHLLTVENTTGAGVTKDEIIQSYIESKEEEIDSIEQLEAEQALMAKVLKKLVKDQYLLELRGNADQEAPDSQDPSSSADDQVTYLVHPQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGE8</accession>
    <name>I4YGE8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_31679</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957076.1">
        <property type="nucleotide sequence ID" value="XM_006957014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGE8"/>
    <dbReference type="FunCoup" id="I4YGE8">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGE8"/>
    <dbReference type="GeneID" id="18471350"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31679"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="InParanoid" id="I4YGE8"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="250"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="501" mass="55303" checksum="FA7DD163F2ABE120" modified="2012-09-05" version="1">MPEKQQRRQSSSVPRKEVASAILGASAASHTRSNETGDVPHAIPSELEDHYQGLCEQLTVSPARLRLITNAFVKTLRKGLAEPGQTVPMIPTYVFGYPTGEEKGNFIALDLGGTNLRVCHVELKGGGKFEVTQSKYRLTEEQKQEDGQSLFDFCAQCLMTFLKDNFPNGTPEGMALGFTFSYPTLQDRIDQGVLVRWTKGFGNKGVEGKDVTEIFNRSLKKYECPLSVTAIINDTTGTMIASRYTHPNTRIGLILGTGCNAAFMDRMSNITKLNINGCPGDEKMAINCEYGAFDSFEHKHLPRTKYDEVIDLTSNKPHEQAYEKMIAGLYLGEVFRLIICEMVDEGVIFLGQETYKIEQPFIFQTAFLSLMESDTTDEQLLSAGLFLHFFDLTTTQEERHFFKKLAGLIGLRAARLSACGIAAIVTHKGIEDDGCDVAVDGSLYEKYPGYADKMHAALVDILGERGRKVVSRHAEDGSGVGCAIIAAMTKARKDAGKYADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGG5</accession>
    <name>I4YGG5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957091.1">
        <property type="nucleotide sequence ID" value="XM_006957029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGG5"/>
    <dbReference type="GeneID" id="18473534"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59751"/>
    <dbReference type="eggNOG" id="ENOG502S77G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_1"/>
    <dbReference type="InParanoid" id="I4YGG5"/>
    <dbReference type="OMA" id="AAHDFCP"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="176" mass="18521" checksum="53ACB1605850A780" modified="2012-09-05" version="1">MFSRIATVAARAPRAQLAGVSSRRTMLTAQKGLYTAKASATGGGRADGVAKSETTNFKVSIQPPGSENNTNPEELVALGYSTCFLGAMKVAAQQIGKTGPSDAAKVFADVTLNKTDSKESPFTISTHLKIEDTKQDIATLAAVAKQTNSVCPYEIAFKGNIKQTFTAIGKDGNESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGL7</accession>
    <name>I4YGL7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_63132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957142.1">
        <property type="nucleotide sequence ID" value="XM_006957080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGL7"/>
    <dbReference type="STRING" id="671144.I4YGL7"/>
    <dbReference type="GeneID" id="18474810"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63132"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="I4YGL7"/>
    <dbReference type="OMA" id="GVEKKFC"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="143" mass="16287" checksum="B6A395BD466BD95B" modified="2012-09-05" version="1">MSVLLKRLHKEIRDLEKEPLVGISLEPKNPDKPYDWDAIIDGPEGSPYEDGRFQVAISIPNDYPFSPPQMRFLTTIYHCNINKMGSICLDILKNKWSPALSLQKVMLSLSSLLTDCNTDDPLDIQIAKHYKDNKESHDEVSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH42</accession>
    <name>I4YH42_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dabb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_62655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956673.1">
        <property type="nucleotide sequence ID" value="XM_006956611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH42"/>
    <dbReference type="STRING" id="671144.I4YH42"/>
    <dbReference type="GeneID" id="18474772"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62655"/>
    <dbReference type="eggNOG" id="ENOG502RSAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154783_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH42"/>
    <dbReference type="OMA" id="RNEGYNW"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF19">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="92" mass="10374" checksum="CDC9133CA2BB9687" modified="2012-09-05" version="1">MPIAHIVVWKLKNKDEETLNLFKPLYKLNGPTKLTVGEPLRPEKSAGYNYGLYSTFESMDTLNAYLVDPDHVKIVESIKPHVEAAAAFDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH63</accession>
    <name>I4YH63_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COX17 cytochrome c oxidase assembly protein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_43366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956692.1">
        <property type="nucleotide sequence ID" value="XM_006956630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH63"/>
    <dbReference type="FunCoup" id="I4YH63">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH63"/>
    <dbReference type="GeneID" id="18472282"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43366"/>
    <dbReference type="eggNOG" id="ENOG502S7XR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149618_1_2_1"/>
    <dbReference type="InParanoid" id="I4YH63"/>
    <dbReference type="OMA" id="QAHLTCM"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="73" mass="7834" checksum="3BF813FF577849F3" modified="2012-09-05" version="1">MALTPAEASDPKKNPLNPEGLKPCCVCPETKKLRDECFLFNGSNADSSNGSTDACKDVLEAHKACMRSFGFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH74</accession>
    <name>I4YH74_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_27417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956702.1">
        <property type="nucleotide sequence ID" value="XM_006956640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH74"/>
    <dbReference type="FunCoup" id="I4YH74">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YH74"/>
    <dbReference type="GeneID" id="18470992"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27417"/>
    <dbReference type="eggNOG" id="KOG2799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_1"/>
    <dbReference type="InParanoid" id="I4YH74"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="12">
        <location>
            <begin position="260"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="390" mass="41650" checksum="EED73366E2A1B2C5" modified="2012-09-05" version="1">MLAAGQVNTPKSIPAFSADEALAAAKKFDKNELVIKAQVLAGGRGKGHFSNGLQSGVHLIDSPEQAQDLASKMIGSNLITKQTGEAGKLCTAVMLAERRTPKKEYYAAILNDRSSLGPVLVASSEGGMSIEEVARDTPEKIVKTPIDFQNGLSQSEALDIAKKLGFSTDDAIKQAAGIFQNLFKIFKEKDMTQIEINPLAETEDGAVLAMDAKFGFDENAEFRQQDVFKLRDTTQEDPQEVEAAEHGLNFIKLDGNIGCLVNGAGLAMATMDVLTHQGGSPANFLDVGGSATPAAVKKAFELLLTEKSVRAIYVNVFGGIMRCDMIAEGIIKATKELDLKVPLVVRLQGTKSEEARKLIADSGLKIFATTGLDEGARLAVQKANEYAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH84</accession>
    <name>I4YH84_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956712.1">
        <property type="nucleotide sequence ID" value="XM_006956650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH84"/>
    <dbReference type="GeneID" id="18473425"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59559"/>
    <dbReference type="HOGENOM" id="CLU_2470790_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH84"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="88" mass="10042" checksum="A39EA559D1FB766B" modified="2012-09-05" version="1">MIPTIKITCDDQATPKTTIPQSTKKPHLKGRGFVNNMPTQRRRTTPSLDEITRRILQNQQHQSQARRNITTEGKLMINKLGKRVAAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHA0</accession>
    <name>I4YHA0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_27440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956726.1">
        <property type="nucleotide sequence ID" value="XM_006956664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHA0"/>
    <dbReference type="GeneID" id="18470994"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27440"/>
    <dbReference type="HOGENOM" id="CLU_2225261_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHA0"/>
    <dbReference type="OMA" id="EMHESAP"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="106" mass="11786" checksum="84C333CE5B634F24" modified="2012-09-05" version="1">MLTRFARQQTRTIFTSRAVLSSVEGQAKQDPKVIEQERRRQDKAGNKNEHGEDVSPHDHAPGWNPTLATSSEEAAKADRDPHATPEELAKNANRTAEKVNKDTGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHB3</accession>
    <name>I4YHB3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_35810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956737.1">
        <property type="nucleotide sequence ID" value="XM_006956675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHB3"/>
    <dbReference type="STRING" id="671144.I4YHB3"/>
    <dbReference type="GeneID" id="18471932"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35810"/>
    <dbReference type="eggNOG" id="KOG3258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHB3"/>
    <dbReference type="OMA" id="YHIIMVT"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="100" mass="11223" checksum="EB38188814538E13" modified="2012-09-05" version="1">MTQKKPQKGAQHIQLRHILTEKHSKAAEALEKINNGEKFDKVAMEYSQDKARAGGLLGLKKKTDLVEPISSIAFDLPINQPSEIVKSEFGYHILLVEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC0</accession>
    <name>I4YHC0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_43431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956743.1">
        <property type="nucleotide sequence ID" value="XM_006956681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC0"/>
    <dbReference type="STRING" id="671144.I4YHC0"/>
    <dbReference type="GeneID" id="18472289"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43431"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="InParanoid" id="I4YHC0"/>
    <dbReference type="OMA" id="NRIEEWN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="32639" checksum="E48DE14145A27CF0" modified="2012-09-05" version="1">MELDLVHLKLNDDELTFEDKEINKLYLRQNNLELSKSLDIEGNKLEEIDLYDNKISDDNLVNLTNLSNLKILDLSFNLIRSIKDIEKLPLKELYLVQNKIVDISNLNIPTLELLELGGNRIRTIQNLDYLSNLRELWLGKNKITEIANMDNLSNLRILSLQANRISDITGLDGLTNLEELYLSHNNLSSLQGLDNLTQLNTLDIAHNKIETISNVKHLKNLKEFWANSNKITSLEEIESEFKDTPLETIYLEHNPVQQTLNTQYRLKLKLALPQLKQIDATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHC9</accession>
    <name>I4YHC9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_43447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956752.1">
        <property type="nucleotide sequence ID" value="XM_006956690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHC9"/>
    <dbReference type="FunCoup" id="I4YHC9">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHC9"/>
    <dbReference type="GeneID" id="18472290"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43447"/>
    <dbReference type="eggNOG" id="KOG2781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="InParanoid" id="I4YHC9"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="288" mass="33559" checksum="5C1B4675DEDEEE98" modified="2012-09-05" version="1">MLRRQARQRREFIYKKSIEAQEKESYERKQKLKNSLNNQKNLPTELQKDAAELGQELRYDEAQSDPTQSLDDEYNRVGTYDPKILITTARDPSSRLTTFAKELRLVFPNSIRFNRGNYVVKEIADAARANQVTDLIIIHETRGKPDALLLSHFPHGPTVTFTLNNVQLRHDLAGSLDSTVSEQYPHLIFENFSSKLGNRIMNTLKYLFPVPKEDSKRVMTFYNDADFISFRHHVYVKTSHKEVQLAEVGPRFELKPYEIKQGTIENTAADTEWVLRPYQRTASRRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA3</accession>
    <name>I4YIA3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_31181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956361.1">
        <property type="nucleotide sequence ID" value="XM_006956299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA3"/>
    <dbReference type="FunCoup" id="I4YIA3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="18471261"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31181"/>
    <dbReference type="eggNOG" id="KOG0755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_3_1"/>
    <dbReference type="InParanoid" id="I4YIA3"/>
    <dbReference type="OMA" id="GFYDPMR"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="106"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="320" mass="34905" checksum="E23D79EC87CEE4C9" modified="2012-09-05" version="1">MSELSTLEGFICGALASCGAVTLSNPMEVAKTRLQLQGELAKEGIKVYNNVGEVFTKTYKNEGIRGLQRGLGTSYVYQTALNGCRLGFYEPVRRQLNGLFGIPLEKNVTSTSVGAGIVSGMMGAASGNPFYLIKARMQAYSPSLPVGTQHHYRHGFDALRSVVRVEGLGGLLRGIDAAILRTCMGSSVQLPTYIAAKTYFSKHGIFEPNSLANFIFSSSISGACVCLMMQPPDVSLTRMYNQPTIKLENGKTVGQFYKNPIDCMYKTVRAEGFTGLYKGTSAQFLRIAPHTVCCLVFNDLVCGWYSNFKHDYFKSTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA5</accession>
    <name>I4YIA5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-dependent phosphotriesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_62365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956363.1">
        <property type="nucleotide sequence ID" value="XM_006956301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA5"/>
    <dbReference type="STRING" id="671144.I4YIA5"/>
    <dbReference type="GeneID" id="18474741"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62365"/>
    <dbReference type="eggNOG" id="ENOG502RYG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702491_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIA5"/>
    <dbReference type="OMA" id="NACEDVK"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43671" checksum="A772CB0DD84D0244" modified="2012-09-05" version="1">MNIGIILPLVGLIIHGYQIFVGPRIALLGYRNKPVTNLRSQSCIPIPEFEGCEDIRYHPSGNALYLSCAPVESRLLWGPGHGVYKEQTNEDFIGKYDLATNKFSKMSMNTLPEGGLGTHGIDVVDNSDGSATIYLVNHAKNETGGPDFPTTETVEVYKTDKSSNKLTHVRSFNDQNVMYALNAVASDGKGGIYFTNDKPTRVWRGLIDQVLAITDFATSTLGHCNAEGECKSIGSFVSLNGIARIDDDHYVINQMNDGKPLVMERQPDDTLVQIQQFHLGSMMDNVSYDPINDELYIATMPQIHKFLKSQNNPYTGRSPVRIYRLRKTEVSEASYKRIYGEPPAPGSTHYRWRAELILADDGTEVSTVTTVARANDKLYMSGYIHPTGYVCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIF8</accession>
    <name>I4YIF8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_40925</name>
        <name evidence="15" type="ORF">WALSEDRAFT_43035</name>
        <name evidence="14" type="ORF">WALSEDRAFT_59384</name>
        <name evidence="12" type="ORF">WALSEDRAFT_59893</name>
        <name evidence="13" type="ORF">WALSEDRAFT_59928</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
            <strain evidence="14">CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956414.1">
        <property type="nucleotide sequence ID" value="XM_006956352.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956455.1">
        <property type="nucleotide sequence ID" value="XM_006956393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957350.1">
        <property type="nucleotide sequence ID" value="XM_006957288.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957418.1">
        <property type="nucleotide sequence ID" value="XM_006957356.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960216.1">
        <property type="nucleotide sequence ID" value="XM_006960154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIF8"/>
    <dbReference type="FunCoup" id="I4YIF8">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIF8"/>
    <dbReference type="GeneID" id="18472198"/>
    <dbReference type="GeneID" id="18472272"/>
    <dbReference type="GeneID" id="18473324"/>
    <dbReference type="GeneID" id="18473611"/>
    <dbReference type="GeneID" id="18473631"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40925"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43035"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59384"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59893"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59928"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="3345619at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="10">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM23750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM23792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="103" mass="11462" checksum="B74A432A2EC3D8B8" modified="2012-09-05" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDSVTYTEHAKRKTVTALDVVYALKRQGRILYGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIK3</accession>
    <name>I4YIK3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_31278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956458.1">
        <property type="nucleotide sequence ID" value="XM_006956396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIK3"/>
    <dbReference type="FunCoup" id="I4YIK3">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIK3"/>
    <dbReference type="GeneID" id="18471276"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31278"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="I4YIK3"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="145" mass="16240" checksum="E8C113202A5C92D7" modified="2012-09-05" version="1">MPTRLHKTRKSRGHVSAGYGRIGKHRKHPGGRGLAGGQHHHRTNFDKYHPGYFGKVGDRHYHLKHNVYWRPVLNIDKIWSLVSEQDKSQTEKSDLVPVVDTLAHGFGKVLGKGRLSKPVIVKARFVSELAEKKIKEAGGVVVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIR3</accession>
    <name>I4YIR3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_58973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955701.1">
        <property type="nucleotide sequence ID" value="XM_006955639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIR3"/>
    <dbReference type="FunCoup" id="I4YIR3">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIR3"/>
    <dbReference type="GeneID" id="18473100"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58973"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="InParanoid" id="I4YIR3"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM23855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="524" mass="56576" checksum="E9C30011AE6168DB" modified="2012-09-05" version="1">MLARSLKQFSRSSRLSLQLRGYAANPDRNSQFARLSEQDLPSLASIFSSPDTSLLTTLGEKPTATSDDLEPFNVDWMGKYKGQSSIIVKPKTTEEVSKVLKWCNERKVAVVPQGGNTGLVGGSVPLHDEVVLSLSSMNSVRHFDPLSGYVSVDSGIVLENLDNFLAQKGHIVPLDLGAKGSCQIGGNVATNAGGLRMLRYGSLHGNVLGLEVVLPDGRIINGMKGLKKDNTGIDLKQLFIGSEGVLGVITGVTLSTPVRPSATNVAVFALPDYESVQSAFSSARRDLGEILSAFEFFDAASYKLVRSHGHAAERKTFEDGEDAPFFCLVETSGSNKDHDDEKLGAFLEQLMESGIVNDGVLAQDETQIGQLWSLREGIPEAAGKAGRVYKYDLSLPVEKMYSLVHEIRQKLSEKNLLAAEAEGGNGSGPVKTVFGFGHLGDGNLHINIVADAYKKEIEEVVEPYIYELVAKHNGSISAEHGLGLMKAPYVSYSQDSPSLDLMRTLKKTLDPNGILNPYKCVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIY0</accession>
    <name>I4YIY0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_55840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955763.1">
        <property type="nucleotide sequence ID" value="XM_006955701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIY0"/>
    <dbReference type="STRING" id="671144.I4YIY0"/>
    <dbReference type="GeneID" id="18472747"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55840"/>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="InParanoid" id="I4YIY0"/>
    <dbReference type="OMA" id="LWIIELH"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="217" mass="24433" checksum="30C3C20DB48397BA" modified="2012-09-05" version="1">MPSDDVYKITMTRQPDNRIERDFLDLGLSKALDDVEAHWRARRNELYPAASLILTGNGLKFFSNGLVLDKALDDKMFFAGVLDPFILRLSSFPLPTIAAVNGHAFAMGFVLALCCDYLVGKKNGRGWFCMNENEFASTIPPGMLNVLSRRLNNWKLIRETILDCKRWTPPQLHEIGLVDVLCSENELESESIKLGKSVGKYAQKGSYGLLKHNYCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ83</accession>
    <name>I4YJ83_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955858.1">
        <property type="nucleotide sequence ID" value="XM_006955796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ83"/>
    <dbReference type="GeneID" id="18475175"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66895"/>
    <dbReference type="HOGENOM" id="CLU_1435478_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ83"/>
    <dbReference type="OMA" id="MTREMLM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM24025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="205" mass="23147" checksum="B98B17EFC86B488D" modified="2012-09-05" version="1">MSAIYTPQKKPLNDLLARVQALDSATKENPKRKREERAQDVSKRLNDMDSPKQQPTELPDVTMDEPDSNAPAMPYADHSAAYPTIFRATPKNLSVKAHPPNSSTHIYKRPSLDNSSEHSPNIHPDTRSGNHDTNDDDVIVIENLTPKKQYMRKPDSASKVRGGRISEAYKMTPRRKITREMLMPNGDDEESVNKENDSNLEESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB3</accession>
    <name>I4YJB3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955885.1">
        <property type="nucleotide sequence ID" value="XM_006955823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB3"/>
    <dbReference type="FunCoup" id="I4YJB3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJB3"/>
    <dbReference type="GeneID" id="18473156"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59073"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJB3"/>
    <dbReference type="OMA" id="GANWSPM"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="408" mass="45200" checksum="B358CAA375E797EB" modified="2012-09-05" version="1">MPIGRTNTQHIVILGSGVIGVTTAITLAKQGYQVTVCARDLPTDSESTGFASPWAGANWFTFASKFDYRMQRWEEYTFKKLWSLIPSGHVMELPIKVYKSEQAIKDLWHQHLTPNFRRIPGPSNNPDISGVAFTSVSLSAPDYLKHLHQVAKQLGVKFVRKSVSSIHEPFDYTQDLPVADLVVNATGLGARKLQGCNDPQVMPIRGQTVVVDAPNVKECVMAVDSSYGSESAYIIPRPNGQAILGGCFQVGNWDTTIDNDMGKRILERCFELNKNLSPTGKFEDIKVLRHNVGLRPAREGGTRLEIEMLESDKEYEQGTMHPVVHAYGIGPAGFQCSWGMARDVLNLVDEHFKSSRTTTVDLFTSTEAVKSNTTPRSCPTVTSTTRSRSSSQRWMPKSPIISPQTVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJB4</accession>
    <name>I4YJB4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_66921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955886.1">
        <property type="nucleotide sequence ID" value="XM_006955824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJB4"/>
    <dbReference type="FunCoup" id="I4YJB4">
        <property type="interactions" value="807"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJB4"/>
    <dbReference type="GeneID" id="18475179"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66921"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="InParanoid" id="I4YJB4"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM24056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="15876" checksum="996C175C68121B21" modified="2012-09-05" version="1">MAGIKTPRNFRLLEELEKGEKGIGDGSISYGLSDSDDISMTNWNATIIGPGHSTHENRIYTLSVECQKEYPTKPPLLKFISKINLPFVNSANGEIDVNKFNTIKQWKDSYTIEKVLLDLRKEMAAPDNRKLPQPKEGEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE6</accession>
    <name>I4YJE6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_59081</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955914.1">
        <property type="nucleotide sequence ID" value="XM_006955852.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YJE6">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJE6"/>
    <dbReference type="GeneID" id="18473161"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59081"/>
    <dbReference type="eggNOG" id="KOG0970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001718_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJE6"/>
    <dbReference type="OMA" id="MTKMNVG"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="415"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="722"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="88"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM24088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1399" mass="158931" checksum="FC90C02B533B57C6" modified="2012-09-05" version="1">MNRPDFIEDDDGSGYIDNGMEDDWGASDTRYDSEEDTKKRKKKSNAKVRQKESLGAYFARSQSKPTPQPSMNAYRKVVSEDKADSFMQDLLSGLDSDTKSSASLKQPPRREALPKSTVFNQYRPDDSDVNFSSQSNQQLSSDPPYSSDMDSYRSSTKTGQLRRKFTDNANLTASPTKKARNQPPSSDDFDFEPFEEDIKPPVNRIPNSWAKRDVKKEPSPSPIMKPTEPAKMEVDIEEKSAAAPKAWMSVLENMAPSPPPSPKADEEFKREGSVTDSPLYDDDGCVRFYWLDYMEDHGRVVLFGKAYDTEAKKWQSTSVTIEGIQRNLFVVPRQFKLDDDENETGEIVEKTDVFTEMESIRKASKIKSWAAKFVKRSYAFEEKDVPREETDWLKVLYGFNEPAMPLGMTGKTFSHVFGTQTSPFELFVVKRRIMGPCWLKLEDAYVTQKGTTWCKHQFTVTDPKTVQFFNDSDADAPKEPPPLTIMSLSTRSIVNHQLNCRELVAATARVWADVNIEDPTPPEQQASSSITLVRPLGMYPPGFEMKARQQRPKIEPMRNEKAVLSNILASVQRHDPDVLVGHDLLGESLEILLNRMNEMKIPNWSKMGRVRRDKWLKAKFDRNKKITTGRLLCDLSSDQGKSMISSTTWSMTEMVNTHLGTQREDIDPDDTAAYFDSYATSPDRLIHFVKHCEVDAVFNMALAAKVQILPLTRQLTNLAGNSWGRTLTGGRSERNEFILLHEFHRQKMICPDKLSRFDKKAAQLEAAAENGDDEATTKKKGGRKDKFKGGLVFEPKKGLWDKYILVMDFNSLYPSIIQEYNIDFTTVERPEDDDNGEEKIPEIPAPGSGQGVLPKLIATLVNRRKQVKNLMKDKNATPAKLMQLDIRQMALKLTANSMYGCLGFEGSRFYARPLAALTTFKGREILTHTRELAESMQLDVVYGDTDSVFINSNAYSYDDALKVANEFKKHVNDRYKLLEIDLDGVFKRLLLLQKKKYAAIKMAEGKESTEIKGLDMKRREYSQLSKNVSQYVLDQILSGDSTEVVVEHIHDYLTEMGESIRNGKVPLDDYIINKRLGKDPEQYPDSKSQPHVQVAMRMKSKGGTAKSGDVISYVFCASPDGVASKTGKAENAYHPEDLRRKDSNLSLDYEYYITSQVLPPIERLCDNIEGTDRSRLAECLGLDPARFQNHSAGNSNDKEFQTLESQMSDKERFRNAEKFSIRCPGCTEHTEFGSMLDSTNSVQTRGIVCQSCSNILPPGSVNIQLEMQLRQFIAKYYDANLVCNDQSCGNKTRMMSVYGKRCLMSNCLGVMKHEYDDQMLYNQMLYFARLFDVERILKQSNSSSNYAEIQVLCEKNKPLLQVLHNTVSKFLERNARSVVSLTDIFSFMNLQGRRWKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJL4</accession>
    <name>I4YJL4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_26858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955979.1">
        <property type="nucleotide sequence ID" value="XM_006955917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJL4"/>
    <dbReference type="FunCoup" id="I4YJL4">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJL4"/>
    <dbReference type="GeneID" id="18470958"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26858"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJL4"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM24156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="863" mass="94560" checksum="CB8139A8265AB215" modified="2012-09-05" version="1">MDVAALLSASLSPEQQTRATASEQLEQAASQDYPSYIFTLSNELANEQQQPFVRQAAGLAIKNSLVARDSGRAFEQAQRWLALDPGHRTQIKQIVLAALSTKAIGAAAAQVVSAVAAIELPHDQWPELVPTLLSNVTDASDEAKRMTTLVAIGFVCESVPAETLATRSNEILTAVVQGARKEEPSTDVQNAAINALNNSLDFVKENFEREGERNYIMQVICEATQSSSTDVKIGAFKCLVRIMNLYYSKMGFYMERALFGLTVLGMQNPEEGVALQAIEFWSTVCDEEIELALEAQEAAEFGEPVERESKNFAKVALPEILPVLLKLLTQQDEDATDDEWNVSMSAGTCLSLLAQTVTDDIVQPIVPFVESNIRSTDWQAREAAVMAFGSILDGPDSRVLAPLVSQALPTLIEMIRDPSIHVKDTTAWTLGRISDVLIDCIKLDVHLHDLVLALVAGLQDNPRIIGNCCWSLMNLADQLQGIEDADGKTQSSPLSPYYEGILSTLMQVSDRPTNDNNSRTSSYEAISTFITQSPEDSLQTISQVTVALLERMEQLLSMQNQLLGTDDRANWNELQSNLCSAITSVIRRLNKEIKPLADRIMTILLSLISSSGKHSTVLEDAFLAIGAITTALEVDFLPYLEAFMPFLYQALKSHEEYQLCSISVGLIGDICRALGEQSTAYCNNFMNVLLENLAASQLHRSVKPPILSAFGDIGLAIGGQFEPYLPVTMQVLQQAGSMMPDPNNYDLIDYVATLRESILEAYVGIVSGLKVADKSNLLLPYLPSIFNFIQICASDTEHTQATIASAVGLLGDLADAYPRGEAKDFFLQPWVAEILKLSRTRGGTESIRRTAKWAREMIKRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM3</accession>
    <name>I4YJM3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_26865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955986.1">
        <property type="nucleotide sequence ID" value="XM_006955924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJM3"/>
    <dbReference type="FunCoup" id="I4YJM3">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJM3"/>
    <dbReference type="GeneID" id="18470961"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_26865"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001060_7_1_1"/>
    <dbReference type="InParanoid" id="I4YJM3"/>
    <dbReference type="OMA" id="PYCEKPE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="337"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM24165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120869" checksum="CB63E0B291075F4E" modified="2012-09-05" version="1">MLSNKRSFRELEGNQDNLTPNKRNPSEEREALGDIEFDNRPSTPSIHNNVEDLSISEDIQKCLDIIKKGLSEPLVYGQTWYIIPKDWIINLESKASENESIQVDKINTYSLTNGKDLLPNLSIGDQIEIIPEDVNIKLNDWFGYQGPQIKRIVVKTSDIPNTERVELYPPTFRLLALTSQKPTTSPVSEQETTFDLSIDAPLSMLLGMSIATLYPDSLVDSSNVSQRARLWRIPDTTNSPLKIDTLYYLPNTQRDLIDTSNGSLKIYEAMLEDGGTFCLEVLDKFGNWPYNDYEQSVLDQPFGKSGFLDRLESKQSSNTKMMTRSQSSQKVKTKGLVGLQNLGNTCFMNSALQCLSNTSELSVYFLSGLYSKELNPDNPLGMSGQVAESFGQLVNKLWYGSSNSVAPREFKYTLSKFAPSFAGYGQQDTQEFLAFLLDGLHEDLNRIKSKPYTEIPDWEGGTDADVAKLAKTCWDLYKQRNDSIIVDLFQGQFKSTVNCPECDRVSITFDPFMYLTLPLPIQSKWNGSVYYIPYDYNKKRLRIDLELPSNASFKLMKNKISQIVDTNSNNLWVAEEYKGNLFKSFLDDELVSEMQSGDLCFVYELPIHIPQDRHEKIDRVFETNWVMFPVYSSTFKESSSLSGEVFGKPMLIALLRSDAQNYQKVYQAIIEKYLHFTKNDEALKKINIHSKDITLRHLEAPSNSYYSYRTSDVNTGRSNNIERNSKTDLKFRASIVENILKSTLLKKNEKNPVEHIEDVNKIDDQGDLEMKQDNSLQDQSIESLYENLETERQKSLSLIKFGEALVVEWKNDLAEEVFGDDLSSTGLWEQFDVIEDPQYVQSKQTSKSPKKGITIEDCLDEFTKEEKLGEEDLWYCSKCQKHQQATKKFDLWKVPDVLVVHLKRFASSRYNRDKLDQFVDFPIEELNIDDRVGEKQVANSIKLNGGNPVEVGIENSEEDAIYDLYAIDNHYGGLGGGHYTSYARNNESGEFYHFDDSYVSKVNEENVKTKAAYLLFYRKRTTRSIGGKARIDAEEQLKIDDATSSTMTADQVVSENESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJN6</accession>
    <name>I4YJN6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_59129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955999.1">
        <property type="nucleotide sequence ID" value="XM_006955937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJN6"/>
    <dbReference type="STRING" id="671144.I4YJN6"/>
    <dbReference type="GeneID" id="18473188"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59129"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013516_2_1_1"/>
    <dbReference type="InParanoid" id="I4YJN6"/>
    <dbReference type="OMA" id="NYRMKGP"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM24178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="608" mass="69842" checksum="DABD1C66787F1D89" modified="2012-09-05" version="1">MEECATSKLDNLQRINLNNNSLRFQQNPEPSTSYKPTKSIRDYNQPERFEDNKFNFNKLNAELHNLSYKNTWVDDFNQSNVAKNKNTWVNEFKISQPKASVNPNKFINHNQLSHSSTNYVNFNQQQQYTQNNYTSNQHNWDRQFDKFDKPILNEEPKSFSQSQTPNDDLARTARNLIDTVEPDKYDKFRNSEFFSFMKQLSTGEYRLENDEFVSNNTTSENNWTKEFDIPNKESAITGSATENPSLINAPEPYNKLLNIFGPSTSSNDYDVKSSLNGDLEQGTGTGAGVKGPQEAEWDTLQQGLDEIDSTFSNDIKRVDNLGLDQPREYAFEANKSKPDYLNHISHIESVLRENSNNAQAWYELGVCQQENENDSQAISALLKAVELDQEYADPWLALAISYTNESEKVSAMNAINNWLQWKHNQVKSTTLNNQNITSDELIRCLCEIVVQQAKEDIIDADVQVALGVVFSLSESYEKGIDCFRTALSTKPNDWLLLNRLGATLSNSGQCRSSLEFYYRALDLHPTYVRAMFNLGIALMNLKDYDEAIRQILSALAIQSEGNEQGGTNQINFNMWDTLRNCLLQMRRSELTQYCNTRDINALRKHYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJV9</accession>
    <name>I4YJV9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_34894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956067.1">
        <property type="nucleotide sequence ID" value="XM_006956005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJV9"/>
    <dbReference type="FunCoup" id="I4YJV9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJV9"/>
    <dbReference type="GeneID" id="18471889"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34894"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_1_0_1"/>
    <dbReference type="InParanoid" id="I4YJV9"/>
    <dbReference type="OMA" id="HHTHPKL"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="5">
        <location>
            <begin position="189"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM24251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="410" mass="46973" checksum="142B59122B362A62" modified="2012-09-05" version="1">MTSTNSRKLSLPQHFSGSKSKDLRANRTSKGSQKLKVLPEEPTRTPDNADFIDDDDDDDEDDDDDDDIVAPRPEVYQQIAKIPAGAPRKDARLLTKKEKERLPRVTAYCTASSYKQPELLKHLESRRYTHGTEPKVFDDVIYTPYMPSSNHSNNRNEADADLLGVPELIDRKTSRYERFQLGAHTPDVFFFSETGVVIMWGMEESMERRVLSMLKRYEVEKLAAEDVEMEDLNFYYADYTRIFHDVIALLRGSSFMTKLALSHALAQSVKISLFEELISATIEQTKDIPQDIAASGKIGMPRKAIMMQIGQLFILRMNINLVGSVLDSPELFWTYPDLEPLYLAFRQYLEIRQRIDLLNARVEVLQDLLRLLKESVYSRHSESLETVVIWLIVVEIILGLATIIVDLTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y510</accession>
    <name>I4Y510_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_70905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668266">
        <property type="protein sequence ID" value="EIM19052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960901.1">
        <property type="nucleotide sequence ID" value="XM_006960839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y510"/>
    <dbReference type="STRING" id="671144.I4Y510"/>
    <dbReference type="GeneID" id="18475817"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70905"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1490130_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y510"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="181" mass="19536" checksum="D76B1FAC211F2FC6" modified="2012-09-05" version="1">MTQSKSVIVIGAGGTFGSSTCLELARRGYKVTGLDKHAYPSLISAGNDLNKIVRTEYADPLYAHLASEAIEVWKSDNVFNSHFHQTGCPPRIVVKPLRTVVEASTIHLNESASVPLQWTIVSPPLTTKIPAPHVAIQKPASPTHTDITTNDKATITPKVSFGNNSCFKGEVMIVQGQVRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y545</accession>
    <name>I4Y545_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_61649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960871.1">
        <property type="nucleotide sequence ID" value="XM_006960809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y545"/>
    <dbReference type="GeneID" id="18474658"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61649"/>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040265_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y545"/>
    <dbReference type="OMA" id="HDAFSAY"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="3">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36375" checksum="884EB223FC24160B" modified="2012-09-05" version="1">MGSRWDRSNPASAAAAAAAKLSSQYGGPRETDAPYYTRIEVNDLKNRYTLTKSATQQSIYDETGAQVSTKGQWYPDKSRATAADPPLYLLIEAQTQDSFDMAVKKVHELKDSELQPLVEDRSRKFEERAATRRKWDEFKVYLNMEPLRNFNLRAKIVGPGGMFVKYIQQETNTKVQIKGLGSGFLEQDTGVESQEAMHVNIAGPDPSQFTYARELTEDLIAAVRGEWERVQGIVPEVQQQADQSQQYGDMPAIPDPNDKEAVERYNQYWTSHGYDVNDPSFKEWQKQQEEYYAQYYAQYQQQAGQEQTGYHAVPPPNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y559</accession>
    <name>I4Y559_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_61641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668260">
        <property type="protein sequence ID" value="EIM19101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960857.1">
        <property type="nucleotide sequence ID" value="XM_006960795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y559"/>
    <dbReference type="FunCoup" id="I4Y559">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y559"/>
    <dbReference type="GeneID" id="18474653"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61641"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y559"/>
    <dbReference type="OMA" id="GEFACIC"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="11">
        <location>
            <begin position="127"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="11">
        <location>
            <begin position="242"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="318" mass="35299" checksum="63F1E6A4EB76242B" modified="2012-09-05" version="1">MLEARMSEAGTLKKVLDAVRDLISDANWECNEDGISLQAMDNSHVALVTVHLSQDAFEPYRCDRNMPLGINLGSLTKVIKCAKDNDLVTLKADDSGESLGLTFESSNTDRIGEYSIKLLDIDQEHLGIPVTQYDSVISMPSSEFQRICRDLSQLGESIRIDASKEGIRFSVEGDVGKASVLLKQSSGASIEREEESEEEEEEEEDEDEDVKPNVDEDEEGDVKPKDKKRKSSKGGNKTKKVKKAKKDVVEDGVSISLQQQVSLTFSLKYLNNFTRSTPLSNRVTLSLSKDIPLLLEYEFAAGHIKYFLAPKIGDEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C0</accession>
    <name>I4Y5C0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5 14">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_34230</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5 14"/>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960784.1">
        <property type="nucleotide sequence ID" value="XM_006960722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5C0"/>
    <dbReference type="FunCoup" id="I4Y5C0">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5C0"/>
    <dbReference type="GeneID" id="18471837"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34230"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y5C0"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="737"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM19162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="767" mass="84269" checksum="9016F1581EB814E8" modified="2012-09-05" version="1">MFRRASSRLLSRNGLIGSTAAFGLSSYAYLNAQKESISMDDSVDRRPSALWTPPTRDQMLAKLGATNSAEKEELWDLLIVGGGATGAGVAVDAATRGYKTALVERDDFSSGTSSKSTKLVHGGVRYLQKAILELDYEQWKLVREALHERKTFLDIAPYLSQPLPIMLPVYTWWQLPYFFIGCKVYDFLAGSQNMESSYAMFKGKTVESFPMLKSDGLVGSVVYYDGQHNDARMNMALIMTAVHHGATVANHTEVVSLSKDANGKIEGARLRDNIHKTEWDVKAKGVINATGPFSDGIRKFDEPQTQEIVAPSSGVHITLPSYYCSPELGLIDPNTSDGRVIFFLPWLGNVIAGTTDSPSKVERNPAPKEEEIQWIIDEVRRYLSPDLKVRRGDVLSAWSGLRPLVRDPAAKNTQSLVRNHMINISKAGLLTIAGGKWTTYRAMAEETVDAAIKEFGLEPRKCQTTKVKLVGSHGWTPMMFIKLIQQFGLETDVAKHLSATYGSLAWNVAAMTEATGLRWPIHGTRLATTYPFLESEVRYACRSEYAQTSTDVIARRTRLSFLNAQASLEALPRVVDIMAEELGWDLSRKQQEFDEGKEYLMTMGLPPTKQNLSLGDVRSGKVVDRESKEIEDAVFARAQFSPSELETLKDKFAALDVDHDGSITREDLGKSLHNLGYENVSEQAITDVLRDTQHRDGVNFTEFLDLASGLKEVSLSNAFTSIISQVPASLQEHVAQTHLGGPEGPNPVGHGAAADANSPAAASGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5C5</accession>
    <name>I4Y5C5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTH1187/YkoF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_41721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960789.1">
        <property type="nucleotide sequence ID" value="XM_006960727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5C5"/>
    <dbReference type="GeneID" id="18472226"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_41721"/>
    <dbReference type="eggNOG" id="ENOG502S45I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5C5"/>
    <dbReference type="OMA" id="KYKMHGY"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="110" mass="12303" checksum="35C8453289F6998F" modified="2012-09-05" version="1">MYCCADFCLIPFGNFKLDDSSSSVARELAIVHQTLEQTRLTFKLNGHGTEIEGEWDDVTRAIKQCHQALHERGVSRICSDIRISTRIDKQSTDGANQAKVKAVHDVLNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5D0</accession>
    <name>I4Y5D0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_70824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668256">
        <property type="protein sequence ID" value="EIM19172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960793.1">
        <property type="nucleotide sequence ID" value="XM_006960731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5D0"/>
    <dbReference type="STRING" id="671144.I4Y5D0"/>
    <dbReference type="GeneID" id="18475792"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70824"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647597_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5D0"/>
    <dbReference type="OMA" id="QSPMSIM"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="388" mass="43609" checksum="A1AF8EAC706C021C" modified="2012-09-05" version="1">MTNQEGLFKCNICGQTFTRRQHESRHQRIHTGEKPYKCSHCPDAFSRSDLLNRHISKAHPTVEIIPKRTNGRPGSRSNRVTNISQQPISKAQRNHDKLVDAEANASANGLPYQQANDDEINKFMPTLVGTSAPTTITDSNFLIKSATDNWLSQSNPNTLPLSPMSILLQNQNPELQQNDDFSYLFNHDNIMSNFLNSPSIQVEQNFATNTLKVSTPNMVIESPFDTFDKAQGSQVTNDFIAALKKRSSQNLRKMSLKMPQNGTHTRLIGDSSHGVTTFHLNTKPMQKKRMMKKAKEMATESLKHEEVSPKNEPLSAGTPDLISSELSSPSSVSVVSPNDYSRNQAQQAINAIQKLRFRDESKPKLTEDLPFQDDFIDPHHFMSSFLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5G3</accession>
    <name>I4Y5G3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_61600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960777.1">
        <property type="nucleotide sequence ID" value="XM_006960715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5G3"/>
    <dbReference type="FunCoup" id="I4Y5G3">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5G3"/>
    <dbReference type="GeneID" id="18474632"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61600"/>
    <dbReference type="eggNOG" id="KOG0726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="InParanoid" id="I4Y5G3"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM19205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="439" mass="49304" checksum="5711F54DEAA6B925" modified="2012-09-05" version="1">MGQQQSQPNKKQQGDKDKQQKRWEPPVPTRTGKKAKRGPSAVTKLPTVNPTTRCRLRLLKQERIKDYLLLEEEFIRNQAILKPNASEDDPHSEERSKLDELRGLPIAIGTLEEIIDDEHAIITTATGPEQYVMILSFVDKDLLEPGCSVLLHNKNMAVIGVLSDDQDPTVSVMKLDKAPQESYADIGGLDQQIQEIKEAVELPLTHPELYEEMGIKPPKGVILYGQPGTGKTLLVKAVAHQTSATFLRIVGSELIQKYLGDGPKLVRELFKVAEENSPAIVFIDEIDAVGTKRYDSQSGGEREIQRTMLELLNQLDGFDTRGDVKVIMATNKIETLDPALIRPGRIDRKIEFPLPDIKTKRHIFKLHTSRMNLSEDVNLEEYVMAKDELSGADIKAVATEAGLLALRERRMRVTKKDFDSARERILYQKQDSGPAGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5N9</accession>
    <name>I4Y5N9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">General transcription factor IIA subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Transcription initiation factor IIA small chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_8071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960645.1">
        <property type="nucleotide sequence ID" value="XM_006960583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5N9"/>
    <dbReference type="FunCoup" id="I4Y5N9">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5N9"/>
    <dbReference type="GeneID" id="18475834"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_8071"/>
    <dbReference type="eggNOG" id="KOG3463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112964_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y5N9"/>
    <dbReference type="OMA" id="MTTFDKC"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="113" mass="13065" checksum="D1D302C96CA2C7ED" modified="2012-09-05" version="1" fragment="single">MNNNQNYFELYRRSRLVLYVGIALTDSLDELITSGHINPELAMKVLTQFDKSMMNALSNQVKNKTQMRGHLHTYRLCDEVWTFIVKNPTFKVDQGDLVNANKIKIVACRNNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5U9</accession>
    <name>I4Y5U9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_49185</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960617.1">
        <property type="nucleotide sequence ID" value="XM_006960555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5U9"/>
    <dbReference type="FunCoup" id="I4Y5U9">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y5U9"/>
    <dbReference type="GeneID" id="18472487"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_49185"/>
    <dbReference type="eggNOG" id="KOG2831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="InParanoid" id="I4Y5U9"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="60"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="228"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="303" mass="33060" checksum="297F4E42FD6668DB" modified="2012-09-05" version="1">MDLLSESLKGRLLFAIPKKGRLYEKCIELLSGADIQFTRSNRLDIALSRNHNLALVFLPASDIPRFVGEGNVALGITGQDMIAEAAVENLVTEVLPLGFGKCRLQIQTPERGPLQKVEDLAGKTIATSFEVLSGKFFSKLDEQRGDGVSTKVEYLDGSVEAACTLGVADAIVDLVESGETMRAAGLHAIHTLMTSEAVLIQSNKKVQNEDQELLIKKIISRIRGVMAAKKYVLCNYNIERKHLDAAIKYTPGRRAPTVSPLENEGWVAVSSMVERKQLAESMDGLENSGAHDILVIALDNCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y624</accession>
    <name>I4Y624_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_34079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668251">
        <property type="protein sequence ID" value="EIM19416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960566.1">
        <property type="nucleotide sequence ID" value="XM_006960504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y624"/>
    <dbReference type="STRING" id="671144.I4Y624"/>
    <dbReference type="GeneID" id="18471810"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34079"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053742_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y624"/>
    <dbReference type="OMA" id="LENVHEH"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="286" mass="31839" checksum="B22CF2810C481525" modified="2012-09-05" version="1">MATNPVYSYHEKQHFDLGSSSRKRKIGIESLRRFDQCALCLSRARDAVITLSGVIFCRECIYADLLSQKQEIKKAKNVLKQLKDNEESERTRKLEEARRRVLENFDRVQQVGTSAKKAEATKNAEETALEELAKEQYEAKKSKLPSFWLSSLQPDSSPIADKIRTLENTKMVTMCRQANPPHPMSLKDLHGVILKSNKGDAESIVCASCNKTLNNSTPMFASKGCSNILCKYCIDTLYKALKQCPVCDNPVKDANEDLIKVSVEGTGFAAGGGVMLKRRTGALGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y657</accession>
    <name>I4Y657_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_34020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960481.1">
        <property type="nucleotide sequence ID" value="XM_006960419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y657"/>
    <dbReference type="GeneID" id="18471796"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34020"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y657"/>
    <dbReference type="OMA" id="PRWIQHW"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="195"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="471" mass="54036" checksum="27CF8F4B34269F4C" modified="2012-09-05" version="1">MRLFNKYNSYDLLPGYSNNNGLFSTNNRRRIALYTDRLKPSGSFITGLTVASLVFTFLSVFPRAPPSIPFAFEEPQPEKPDCLSCSLDPNVALVDSHSVSKPLADPTLNKQLSESQCLKEYDGLFYEAERAFDWWSERGGITKEHLEKASDKAHGRVVIHNNRMYVKEYRHGDVNTRAMATFAAIHEAVLTSPGAIPNVEFTFQIQDAGDSYDEPIPTFVLDRTADQPELWLMPDFGFWSWPEPKVGSYVEVRDKAGKWESKHSWSEKLPKVFWRGASLGLPIRDQLVDAARGHAWSDVKIMNWGDIQPGDLLTMEEHCGFQYLIHVEGVAYSGRLKYLLQCHSVSVMHEMKFIQHFHHLLDGHTNSTNQNVVIVPLPEKRPGSNTEPDPWQRLPEVMNELRKHPDRVRQIADNSWNGLRNRYLTPSATVCYWRRLFSLWHEAQAFEVEVGDDYIPYESFMLMGTTDWSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K9</accession>
    <name>I4Y6K9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960399.1">
        <property type="nucleotide sequence ID" value="XM_006960337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K9"/>
    <dbReference type="GeneID" id="18471138"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30292"/>
    <dbReference type="HOGENOM" id="CLU_987672_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6K9"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32382" checksum="DD025D9C66084420" modified="2012-09-05" version="1">MPSVKEKQDDSNLYANQMKREKLNGDNTNKPIQFASPKQRSKILDFVGSPSKKGKTPSKKTRSDGLFQLTPIDPIDEVQDLLEKEETTIPENTNSSQLDVYKMENMIDLQQLLDKENNINREFNRNSSEGASNNDHSSSNNATTSSKTLSNNVDTEDLNHVGCNGKSSNGKPTNNDHYLQEITLDILDHNERLELELRKQRWQMCTLDEWKSDGLEIIDEFAELIRQVQERVTSKIDNMTDFINRIKEGKIVLKEQKHKLDVSKEEVNEATKSLILKKKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y1</accession>
    <name>I4Y6Y1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960231.1">
        <property type="nucleotide sequence ID" value="XM_006960169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y1"/>
    <dbReference type="FunCoup" id="I4Y6Y1">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6Y1"/>
    <dbReference type="GeneID" id="18475728"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70391"/>
    <dbReference type="eggNOG" id="KOG0002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Y1"/>
    <dbReference type="OMA" id="RRTKMNI"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM19723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="65" mass="8144" checksum="F1BFDC762FEF6CF2" modified="2012-09-05" version="1">MRSQNNSVQLEREKRSANKTFRLKRTLAKKQRQNRPIPQWFRLKSDTNIQYNAKRRHWRRTKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y731</accession>
    <name>I4Y731_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_70304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960108.1">
        <property type="nucleotide sequence ID" value="XM_006960046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y731"/>
    <dbReference type="FunCoup" id="I4Y731">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y731"/>
    <dbReference type="GeneID" id="18475710"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70304"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012847_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y731"/>
    <dbReference type="OMA" id="AFYPNNP"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM19773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="45268" checksum="638B37DF8BEB040F" modified="2012-09-05" version="1">MVNTGQKNNTAHKRIKQHQNRIYANPLPVLIDQRPSTFLAGLSRFGQKSLINPSCVGIYIKETQSVWVINERDIRVLWTRGFFGKGSLSRSEPTWNDRQRKLAVGDKPQPTAEEITSKRRVERNKMKIERAKVLTEAQLAAEAALAGIDAIKESPPVPVDEDNNDIVLNDKTSRGFEPSSPPKWEPLEPDEQEEQEDLSNAEHLQLTLQEAFFLAWGVGCLRIIDPQKDIFMSNRQLWKEFRYLPITLDSNSVNIDRLDNPFLVNYAVYHHYRSLGWVIKSGIKFCVDMVLYKRGPVFHHAEFAVVICPTYEDEADKSTSPFKLHNTDELSWQWLNTINRVNSQAKKTLILAYVEIPSKKRVENIDEPTEVLKEYNVKEVVIKRFVAARNRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y734</accession>
    <name>I4Y734_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_21788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960111.1">
        <property type="nucleotide sequence ID" value="XM_006960049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y734"/>
    <dbReference type="FunCoup" id="I4Y734">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y734"/>
    <dbReference type="GeneID" id="18470898"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21788"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y734"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="312" mass="33926" checksum="D090869EC021D1B2" modified="2012-09-05" version="1">MGANRTEKEQYFNRLQELVETYPSIFIVNIDNVSSNQMHQIRQALRGKGQVLMGKNTMVRRALKIFIQSNPQFERLLAHVKGNIGFVFTSGDLKDIRDIIVANKVKAPARAGLYSPEDVYIPAGNTGMEPGKTSFFQALGVPTKIARGTIEIVSDIRVVEANTRVGASEATLLNMLNISPFTFGMTCVQVYDNGQIFSPSVLDVSEETLVGRLLTAGNQIAAISLAINYPTLPSVMHSFVNSFKNVLAVSISTDYTFEYSEKIKDMIANPDAYAAAAPAAAAASGGEAAPAAEEKKEEEEDEDEDMGLGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y792</accession>
    <name>I4Y792_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_70349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960168.1">
        <property type="nucleotide sequence ID" value="XM_006960106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y792"/>
    <dbReference type="FunCoup" id="I4Y792">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y792"/>
    <dbReference type="GeneID" id="18475720"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70349"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y792"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM19834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="329" mass="35761" checksum="88841F4FA2E27421" modified="2012-09-05" version="1">MSERVHNRVVIIGSGPAGHTAAVYLARAEMQPVLFEGMLANGIAPGGQLTTTTDVENYPGFPDGIRGPEMMDKFRAQSERFGTTIHTETISKVDLSKRPFKYWREGSEEDDNAYELADSIILATGASAKRLFLPGEETYWQSGISACAVCDGAAPIFRNKSLAVIGGGDSAAEEATYLTKYASHVHVLVRRHELRASKIMAQRLLKHPKVTVHWNTQATEALGDGDLLQALTLKDVQSGETRKLDVNGLFYAIGHEPATQLVRSQVDTDEDGYIKTVPGTTQTNIKGLFAAGDVQDKRYRQAITSAGSGCMAALECERLLAEEEVEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C1</accession>
    <name>I4Y7C1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_33688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960005.1">
        <property type="nucleotide sequence ID" value="XM_006959943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C1"/>
    <dbReference type="STRING" id="671144.I4Y7C1"/>
    <dbReference type="GeneID" id="18471730"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33688"/>
    <dbReference type="eggNOG" id="ENOG502SW7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703158_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7C1"/>
    <dbReference type="OMA" id="PWATIPV"/>
    <dbReference type="OrthoDB" id="3362598at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697456" evidence="3">
        <location>
            <begin position="24"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="393" mass="42968" checksum="B843614C13C34385" modified="2012-09-05" version="1" fragment="single">MVFKNGHTRFYLLLAVLSISIKADVPCIGSASSITWWQTKNDNPCGLMEETARVCNSQAAVDRITYGGDYRADPDSCECSVPYFNLANACAYCGTGDHNRGTSKDEFFEKCDKNNLNVSPQFPENVTQTYLVPPWATMAIPASGNWSFDDAEAYASENPTPTESAKPTDPSDHHYSVGAVVGGTLGGVFALALVVAIAVLIWCRRSSTAARRRRLMMRAQGIPTKVKDTDSIFEIDDEPRRDHDDLDKAYIPVPYTGSAGSQTSARQSGLWGTPSPGFAASGRFGQHSHRRSQPSSGVNPLDDENSLYSRPSVYSRPGSFAPLQSPLPAVRKGVEAGYDYFGSNKNRSSFAVNNQHVHHESDAGVSLYSDSQEDSTKQSLPPMYTDVYKRNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7C7</accession>
    <name>I4Y7C7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Las1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_61231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960011.1">
        <property type="nucleotide sequence ID" value="XM_006959949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7C7"/>
    <dbReference type="STRING" id="671144.I4Y7C7"/>
    <dbReference type="GeneID" id="18474406"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61231"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1344167_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7C7"/>
    <dbReference type="OMA" id="HISSIEH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM19869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="204" mass="23133" checksum="0622FC5CB24B780D" modified="2012-09-05" version="1">MRTTPWCNKNEFRQVYSGLFQTGDRNESVNTLKLWLNRGNCPHSIESTLSLMESLDMTTKGDISQNQKQLLMSIAIIRFVNGLVDPLQQFSFARSIHDLAKQIDLPLKFVQLRHTSTHDNLPSLKVLTQSTIDALDWLRTRYWDVVLSTLEEGNSTVDSMETRLEALNSILTDDSPNESGWTAASNFKPSAIGLLNNKKSNLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7F1</accession>
    <name>I4Y7F1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_58470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960035.1">
        <property type="nucleotide sequence ID" value="XM_006959973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7F1"/>
    <dbReference type="STRING" id="671144.I4Y7F1"/>
    <dbReference type="GeneID" id="18473022"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58470"/>
    <dbReference type="HOGENOM" id="CLU_1042822_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7F1"/>
    <dbReference type="OMA" id="INEDAMF"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697459" evidence="2">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="267" mass="29098" checksum="41108BC7BDD62AC6" modified="2012-09-05" version="1">MRLSVALGIIAVLAAQVTAQAGPLDALGKLAGGLIPGGDSSSSPAAQPSPTSSATPTQSPTSKPSSSTTPTPSPSSSTEEAQSEEPVAERQESSDVEPVKEDDEQETTEEDVQPAEEQVDQQQDEQPVDEQTQQVEQSADEQAQPAEEPQIDEQPAAGEQQDEQSVEEQQQQDEQPAEEPQDEQQAEEQQQDEQPAEEQQQQDEQPAEEQQQQDEQSAEEPQAEEQQQDEQATEEQPAKRGTSNFMRGYKRLTRSLKRSAPGSRKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7K3</accession>
    <name>I4Y7K3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_33749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960083.1">
        <property type="nucleotide sequence ID" value="XM_006960021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7K3"/>
    <dbReference type="FunCoup" id="I4Y7K3">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="GeneID" id="18471739"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33749"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="InParanoid" id="I4Y7K3"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="175" mass="19589" checksum="4ABA0ADBDBEB5562" modified="2012-09-05" version="1">MASAADIQAKLNYYVGQVDKQLAAYPQLAKIESQLGVPKAYVVPGLALLLFLFVFFNIGASFISNLIGFAVPAYYAFLAIESPGHDDDIQWLTYFVVFSFFTFAESLVNIVTYFPFYYLFKIGFTAWLMLPQTKGAKTLYLNVLRPVLFSKNKTQPRGSFTADDLRQKANAATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7N9</accession>
    <name>I4Y7N9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_65771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM19981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959912.1">
        <property type="nucleotide sequence ID" value="XM_006959850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7N9"/>
    <dbReference type="FunCoup" id="I4Y7N9">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7N9"/>
    <dbReference type="GeneID" id="18475051"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65771"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="InParanoid" id="I4Y7N9"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="426"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="747" mass="85288" checksum="562D9DAFD413AE29" modified="2012-09-05" version="1">MTKECKLVYAKSKVYVHTGKDTIAGYLALVDRTGDQKYTEKENLLLSWLPQSIIQEMNEEDKFVMVESTNKPTTLVNPPPSDSDSYAFSLPVKEIYSMLVYPPSITHWYGTITINLLGGVTLPALHFHDDENSTALTSPRPSLSDSLYPPSRHISSTWGGQEFLLCLKLYVTLLRSQLENSLFLVEPTEMDAQIHLQPFLDENVLETSTPSSSTPPRHGRRTSILHYALNAHNNHMTRNATRFNNHQHSRSADNMRQLFPDNVLDATPSVDNLTSVYRNTIRSFANITNSAKQTAHSMLRHPLAKPIIPHLPTPVQSLAVASGNTSMSGNTAGEYDSARIYLAKWARRVAEEGDKNRLKENDVLRSADLGVSTELGKFELLDKSQEKTTRDPSNPITLEEWQTWFDGDGKPSITESEMLLSVFRRSIESSAKIHIWPFILGVIEWNTTEKERIAAWNRLDTQYAQLKDTWKNKSVFHDKKVAEERHRIRVDCLRTDRNLPLFAKSDTELDEMELGVGTLDSSSGSESELSDDNEGTSQAVSNAHVRRLQGILLTYNFYEEGLGYVQGMSDLCAPLYVISEASGSWTFWCFVSVMNRTKENFLADQSGMSRKLITLQELIKVMDPELYIHFAKSDNLNMFFCFRWILVNFKREFNFNDILTLWEALFTRPHSQHFELFIVLAVLESHRDIILKYLMEFDEMLKYCNDLSGTIDVQQTLNAAEVLYDNFVKLYERLKGKKLSENLSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7R6</accession>
    <name>I4Y7R6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_58407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959938.1">
        <property type="nucleotide sequence ID" value="XM_006959876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7R6"/>
    <dbReference type="STRING" id="671144.I4Y7R6"/>
    <dbReference type="GeneID" id="18473015"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_58407"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032418_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7R6"/>
    <dbReference type="OMA" id="HINAGRD"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="595" mass="66201" checksum="2D2439BFE5207749" modified="2012-09-05" version="1">MPKTLPRGSACLACRRKKTRCDGSKPICGNCVKSGGLECVYDDEARQSVRRMTKLRAYEERIRDLEMELQNIKLGNNTDIQGSSPGTSNTPLNIASSSWPKDFPPRDMALYLINIFYSCAPFASSDISKTNFESRLMHLPANSPQFPSGALCHAIFATAYQHLPNKTPGDKHSALAMQKMSDPGSGPGLMFVLERILAAIILSQHLHAIDNKSELYIPAIFAARGVVAFSLNHDNDYPSKWFLKEPKSDLEAEERRRLYFKAYIIDQLYSSDTGISPNVLHEDHIFTPLPCPQKVYQSSTHTSTIPKSTEYVHSPVFFLQNSSDGLSLLIKATILLGRVNIWHMRGFYDAKAANLSSPSQLPSFIELDTLIQVFRQAFPQEYSDPVRIDEQGLDVDNLAAHMVAVECMLSLHRVFKNEPLSQSRLLFFSRVAVNSVYRIKATSYDTTRLPSFLLMTYSKAASVLIDAYVQARTIHDEAAYIENELLAIGDLFQSMSKHIPAAATCLGALEDKAVKAGLQNFSQMLSGETLSLPQELVVPVSQQPTSNWISLDTTTTATAFDDYDLLSGASFTITDENRWLNNTGNTDSFDSFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y863</accession>
    <name>I4Y863_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_21147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959876.1">
        <property type="nucleotide sequence ID" value="XM_006959814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y863"/>
    <dbReference type="STRING" id="671144.I4Y863"/>
    <dbReference type="GeneID" id="18470876"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_21147"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189359_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y863"/>
    <dbReference type="OMA" id="PANEAHK"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="89" mass="10156" checksum="619B9CE21875B4FB" modified="2012-09-05" version="1">MANAGKIDPKSLLENDSNRLLGKRKIQELVETVDPSETLDPEVEDLMLEIADEFIESVTNFGCMLAKHRRGDTLEVRDLQLHLGRYLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y899</accession>
    <name>I4Y899_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959679.1">
        <property type="nucleotide sequence ID" value="XM_006959617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y899"/>
    <dbReference type="GeneID" id="18474305"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61045"/>
    <dbReference type="HOGENOM" id="CLU_1242754_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y899"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="223" mass="25229" checksum="89B2EF8049B6F50F" modified="2012-09-05" version="1" fragment="single">MLVDTSIPIIEESNEEQDMSPALASTRGSFETFRGDNEDKKTRSLRMTLDWLAPNNTRKLKQTEAELSNHRRMTSSGSTYSSSATDFTMPCDNSEVASISSASLFTSDTSYSRAYTPPNVFENSYRSKMQQTPPPVPTNSRPPATPTLYTKEGLPIDLAQLMQLLGTQNQHYQQFQPQPQYQQTQQFGHPQVAYQHAPSPQYAYTDVRPLHKPVSTPLFRERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E9</accession>
    <name>I4Y8E9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_33477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959729.1">
        <property type="nucleotide sequence ID" value="XM_006959667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E9"/>
    <dbReference type="GeneID" id="18471691"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33477"/>
    <dbReference type="HOGENOM" id="CLU_1817296_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8E9"/>
    <dbReference type="OrthoDB" id="10507451at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="142" mass="16819" checksum="E5FA94FA40E07C45" modified="2012-09-05" version="1">MKKPHHGIQRPMVHLLKNEKGELLKVPCMHHNKVDRPHHPHHKVDHPRPHHKIDHSRPHHKPNCLHNQIHKVFTPLKHKLESLSTLLKLIIGLSFSAFFLSLFCITRAIKRAREQRRLYESLPTYDQVEIVTDEQPQMQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8J7</accession>
    <name>I4Y8J7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959777.1">
        <property type="nucleotide sequence ID" value="XM_006959715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8J7"/>
    <dbReference type="GeneID" id="18475040"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65641"/>
    <dbReference type="HOGENOM" id="CLU_1385134_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8J7"/>
    <dbReference type="OMA" id="TNEADQW"/>
    <dbReference type="OrthoDB" id="3353962at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="197" mass="22807" checksum="BBC118B655B8666E" modified="2012-09-05" version="1">MSRIFSRTISHSIRRRQQDWWFVEQPITSTSTATATTASSPPSELPESLRELHNYLNTLPYLNKSSITWKHIDEFQRESDELINNEVSSALNPWIWAGKVSLLEGIGKRGVERTFKDLRSYFKMRSEIARMYGLEPPERRKYARKGLSNLRKSQGDLIKDKGSWGLIEHFDSKTGVAAVIGVWEKENEVDDWGVFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8M9</accession>
    <name>I4Y8M9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_29667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959578.1">
        <property type="nucleotide sequence ID" value="XM_006959516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8M9"/>
    <dbReference type="FunCoup" id="I4Y8M9">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8M9"/>
    <dbReference type="GeneID" id="18471107"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29667"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8M9"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="133" mass="15121" checksum="021253EB12222B45" modified="2012-09-05" version="1">MSSLSMLGNEQADATEEVTWEDQSRINAFSKYNKRLEDIEELLTDRKTEREQLDDLSMELELADEDAPVLYKLGDAFVSISLEKAQEQIEADGESLDSAIEELKSAADDCEKNMSELKVHLKSKFKDSINLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8N6</accession>
    <name>I4Y8N6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_29673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959585.1">
        <property type="nucleotide sequence ID" value="XM_006959523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8N6"/>
    <dbReference type="STRING" id="671144.I4Y8N6"/>
    <dbReference type="GeneID" id="18471108"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29673"/>
    <dbReference type="HOGENOM" id="CLU_809424_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8N6"/>
    <dbReference type="OMA" id="DSNACRE"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="110"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="343" mass="40026" checksum="1F7BDDA8264A0082" modified="2012-09-05" version="1">MNTNKKVKQARVYLNDLNSKPLLVEVTKSYIGLDLIKYALSTRNLIIENPKNKINLIEFNNNCFRFIRNFENLFDQITNWYDDNNYFLVNSKKNYLKDSLSVSKSINVSIFHHKEVLFQLDSRKWVKRFLILENNNLFISKSDKHKDKQFLCNLLSYDVYSFKELYPNCPKPARILDDTLYGHLFLIKSQDNHSLFEKSEDIQHLFAANDSNESKEWIKAITQARTNAIINEKPWLFKNPIKNQDSSPEFKTKLTPTKSISRSNSQGKTMSRSNSLFKPRDNQQTLINLKDESIFTQGSLLARRESERAPSFLKHDPSLKASKSNVTRKRSGTLNLTHSSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Q0</accession>
    <name>I4Y8Q0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_65470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959599.1">
        <property type="nucleotide sequence ID" value="XM_006959537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Q0"/>
    <dbReference type="FunCoup" id="I4Y8Q0">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8Q0"/>
    <dbReference type="MEROPS" id="T03.011"/>
    <dbReference type="GeneID" id="18475024"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65470"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Q0"/>
    <dbReference type="OMA" id="ICGMGPP"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="339"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="509" mass="55526" checksum="970455F944F2895F" modified="2012-09-05" version="1">MGVDVLKNGGNAADAAVTSTLCIGVMNMFSSGIGGGGFLLHRTPEGDISSIDFRETAPGLADPYMFYEHPHSAQIGGLAVGTPGELAGLHALHEQYGSLEWKDLVLPAAELAKGWPVPKELARRIEISRDWILKDPIWKEWLAPHGTTLKEGDWIARPAYASTLETIAEQGVSAFYEGEIGESFVRTARDAGGILTVDDLHHYKVVYGKGYNTSVNGLDVHTCGFPTSGPVMLFMLNALESLDMVPPRKTADDLHKFIETMKFGFAERTRIGDVPFMNDTTAMLNMLNKSYAQETVDKITDRTHTWEYYGPDFEGKDTHGTTHLTLVDDDDGVVTLTSTVNGLFGSHVLDEHTGIILNNEMDDFSIPGHPNMFGLWPSPYNLPEPYKRPLSSTAPTIVEREGNLVAALGGSGGSRIFGSVLQTLLHILQGYNPSAAIEAPRVHDQLFPPVVTFESGFSRHLIREMRLRGHNTTVFDFNLGAADVQAVTIEDNFKYAASDSRKGGVAAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Q9</accession>
    <name>I4Y8Q9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_40046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959608.1">
        <property type="nucleotide sequence ID" value="XM_006959546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Q9"/>
    <dbReference type="STRING" id="671144.I4Y8Q9"/>
    <dbReference type="GeneID" id="18472150"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_40046"/>
    <dbReference type="eggNOG" id="ENOG502S11B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073382_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Q9"/>
    <dbReference type="OMA" id="GYWLNGH"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="154" mass="17668" checksum="B39576D069C9DADB" modified="2012-09-05" version="1">MSSTHSGLIRVVKCPGDYMSYALADKDFKKDEIISYLDSASYSERAYTSVQVDSDKHIELNCDLVYINHSCEPNVAFVINGQDKKNWFLKALVDIKKDTPLEFFYPSTEWSMDQAFDCHCKKDNCLGFIKGAAFINKENLKNYFVNQHILSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8S4</accession>
    <name>I4Y8S4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959623.1">
        <property type="nucleotide sequence ID" value="XM_006959561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8S4"/>
    <dbReference type="GeneID" id="18474287"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61021"/>
    <dbReference type="HOGENOM" id="CLU_1760240_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8S4"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="148" mass="16337" checksum="773F18A1BD19EDA1" modified="2012-09-05" version="1">MSDITYTHLKKEDIEALQLLHKQTLTGVPPDSGFYLTMQLVSDCLCLVGKNDAGEILSFITGRCVEGIVHVLTLSVSEKYRRQGIATTLIRKLLSELSEDEIARVEIHTGGSTDEANVFCTSLGLEERHLPDHLKAENGTSYHGTIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8V3</accession>
    <name>I4Y8V3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959651.1">
        <property type="nucleotide sequence ID" value="XM_006959589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8V3"/>
    <dbReference type="GeneID" id="18471679"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33429"/>
    <dbReference type="HOGENOM" id="CLU_3015967_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8V3"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698669" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="56" mass="5675" checksum="5236E3419C61BF15" modified="2012-09-05" version="1">MFKSIIALALLATATTVSAGGMQVCTGKGGCIEKQITKDCCAAVGDQNGRLSTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8Y9</accession>
    <name>I4Y8Y9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959457.1">
        <property type="nucleotide sequence ID" value="XM_006959395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8Y9"/>
    <dbReference type="STRING" id="671144.I4Y8Y9"/>
    <dbReference type="GeneID" id="18475644"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69798"/>
    <dbReference type="HOGENOM" id="CLU_1714728_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8Y9"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="153" mass="17692" checksum="3A745B58E91B9B4C" modified="2012-09-05" version="1">MSNSELDIHCPRLIRVFVRTTQPYDAYSFDKGLPSKDEYDILAGPNTTIRELLLLLQKSLPENLRHPRSIYGVHSIYVDMKSMYHKERDLGRYSLSVKNYSDKYDDQSTLDEARIYPGDYLSVHLQLPYSGSRRPPSGPPGRRPPVDNGYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y921</accession>
    <name>I4Y921_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">F420H2 dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959489.1">
        <property type="nucleotide sequence ID" value="XM_006959427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y921"/>
    <dbReference type="STRING" id="671144.I4Y921"/>
    <dbReference type="GeneID" id="18474259"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60930"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y921"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="81"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="261" mass="30002" checksum="89F217A690CF1F02" modified="2012-09-05" version="1">MSIMNTFRRSVRGISTSSRLMQAGLESQPSADFNINAPRNPAIDTEYLQSPLHEYGSYLMAAMPKFIQQFSVYKDELTLMTAPSGVIPTLEFLKQHTQSQFKSAMDITAADYPTKSQRFEVIYNLLSVRYNARIRVKTYADEVTPVPSATGVYRGADWFEREVWDMYGVFFTGHPDLRRILTDYGFEGHPLRKDFPLTGYTELRYDEEKKRVVQEPLQLTQAFRNFEGAASVWEQVGEGVDHKPEQFKLQPPAEEEGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y932</accession>
    <name>I4Y932_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959500.1">
        <property type="nucleotide sequence ID" value="XM_006959438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y932"/>
    <dbReference type="STRING" id="671144.I4Y932"/>
    <dbReference type="GeneID" id="18471652"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33296"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="I4Y932"/>
    <dbReference type="OMA" id="FPFWKAV"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="299" mass="32679" checksum="37384539B7918733" modified="2012-09-05" version="1">MSDSQEKQVVQAPVKRSYPFWLGGVAASLAACLTHPLDLTKVRMQTTAPKDRHNMLKTMIMTVKDQGIKGLYVGLTASVFRQMTYSITRFGAYEQLKSYTSKPGQQSSAANMVLCASGAGALGGIAGNPADIILVRMTSDATKPAAERMGYRNALHGLFRMTKDEGINSLFRGLGPNTVRAILMNASQLASYDYFKRSLVDYAEMEEGLPLHFSASFLAGTLATTVCSPADVIKSRVMSESKKGGSIAEMFKTSLKNEGPGFLFRGWTPAWIRLCPNSIAIFVILEQLRWAVDKARDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y938</accession>
    <name>I4Y938_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959506.1">
        <property type="nucleotide sequence ID" value="XM_006959444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y938"/>
    <dbReference type="STRING" id="671144.I4Y938"/>
    <dbReference type="GeneID" id="18475652"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69840"/>
    <dbReference type="eggNOG" id="KOG2163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321884_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y938"/>
    <dbReference type="OMA" id="HNEACER"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="804"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="950" mass="107766" checksum="1255046F27EEF816" modified="2012-09-05" version="1">MSCVESYVETLSNALSTDEIVALQQKLEADIDSRRLRLAERLNRDKSVHAHQLSQSLSLVQMHSQLSSQSEEISKKIEQTKPTLRTEIEAYESHIYDYNQAKLEHEAKSILDSVQLSLSTFRQYIDTEDLVKAAKFMQDGLKNTFQRLSNSFVARWSGSAALQTECGRLSELLTEKLTKAWNDSVECTQTTLTLRASNGSTPLSETVEALEVLNMSTRRFTNLYNNIKTHFVDILLPSPTNQGLVPTLVANEDTLTLKKTQEAPIKSTQLDSLSTLLHFIDSRYKELGEQLRPVIIERLMEHYLLPSLPVRLGGPDITLFVKRLEEAVAFEKDILSCSQQDTINQFARVWGDSWLQKRRNQVLSNTRSVIVRPDWDTFVAEIEVLVEDSKENVKRDTPAIQPPVEKATDDKEAKDLHQSESKTSITSAMDVDNNNNDDDDGWGLDDDDEGNNVTAALNNVDSKTSIVSMREAAQDDDMEDGWGLEDNEDVEKLKNDDVNDLKVEKPDLSRISSQSSITSPQPDVIEEDDDGWGLDDDEEHIDEDKEEQIGHVQQIDDDDDPWKEDMDEPAARKHDETGNDKVEQDNNQLMHDDDDPWKEDMTDVATKDNASEDGWGLDDDEVIKHEVAQVDTPIHQCGNVVHDKSQMLDTQKSVEVAPTRQELKSRSLVVSQYVKQILLHIDDALNDRQYLLQTNEIPSKDNNLPEKATEVAELVLDFYRSLFPYVHRETIKLVPALALQFINDCEYLSHEVSDRELKTSSKKLELLKQTTLVNVDVEQRRQIVDILTDAGPLTDLSINHERAFAGVISSFSRLRSSVKDVIDKEELNKLLGSVAEFLMRFVIEAVEDMDDISEEDSQKLCKMCRDLQAGLQCVFEENGTEGFKQTDNWFKFAYLSEILQASLVDLSYLHKEGSLVDFSSEELVRLCKALFADTEKRAQVIDDLMVASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y987</accession>
    <name>I4Y987_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_54990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959326.1">
        <property type="nucleotide sequence ID" value="XM_006959264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y987"/>
    <dbReference type="FunCoup" id="I4Y987">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y987"/>
    <dbReference type="GeneID" id="18472708"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54990"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y987"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="230"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="698" mass="77999" checksum="371A455EEA585D57" modified="2012-09-05" version="1">MPKDKSSTTKSNGIKKVKGENFYRDAKKASRVKMYTGGKARRDPNGKIIESAAFQKTEKETDMGRVAPDRRWFGNTRVISQDALNHFRDSLAEKSHDPYSVVLRRNKLPMGLIQEPNLGKAKGMAGNHIVDTEPFSDTFGPGAQRKRPNLDVSSFEELGKSGAGARTEDQLEADAPTPSLDDIKNVNKSKPAVSLGVDQVDQDQIPFDLGDLRNSNREAAYRKGTSKRIWAELYKVIDSSDVIIHVLDSRDPEGTLCNSVLETVRKERSHKQVILVINKVDLVPTWVTAKWVKHLSRTYPTLAMHSNINNSFGKGALIQLLRQFSVLHSDKKQISVGLIGYPNVGKSSIINTLKKKKVCNVAPIPGETKVWQYVSLMKRIYMIDCPGIVPVSKGDSDTDTVLKGVVRVENLATPPEHIGELLKRVRHEYLERTYQITKPTDGVWEGERGTEDVLQKIAKRTGKLLRGGEPDQNAAAKMVLNDWIRGKIPFFTAPPGIDADPVIKTLPEEPQVKPADWKGKGKATEHDEQEDVPSKQLKGVSQPIKQIPVATKFLPDDVKGHEDAFENDNEGELADADADDAIALNEEDDSEEEEEYEEPALEEIGWDEVFNNGEVAESASEDEQPKKVNFASDDEDQPKKTKEPRKTTSKAKKTNYYTTANVKNKNKNKQKPEPPSEEIEKKKRKSGSLRNTQNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y995</accession>
    <name>I4Y995_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_69697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959333.1">
        <property type="nucleotide sequence ID" value="XM_006959271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y995"/>
    <dbReference type="GeneID" id="18475623"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69697"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_3_0_1"/>
    <dbReference type="InParanoid" id="I4Y995"/>
    <dbReference type="OMA" id="SIYPHEW"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29981" checksum="DC639A231DF8DEEC" modified="2012-09-05" version="1">MSLRAVFQEDAEYSEDLFSDSLEAIFGHHQPSQGEPGSKFIYKSPWKNLDIRIPNQPTNGLFSQMQWDSGLFLSDMISDKKGIFNDLSNKRILEFGAGTGLPSLLASLAGSPYVVCSDYDDDSLIENLRRNVQVNDLSNVKVIPHIWGQDVSPLVNEQKYNMILCADTLWMSDQLDNLLKSLSATIDKADPSSRVVIIAGFHTNRPPLAKFFRLAKEYNLIPDENGIKEWDIVDNTTKEFTYEGTLEPSICSRWKIISYLKYVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9C0</accession>
    <name>I4Y9C0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_33204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959356.1">
        <property type="nucleotide sequence ID" value="XM_006959294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9C0"/>
    <dbReference type="FunCoup" id="I4Y9C0">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9C0"/>
    <dbReference type="GeneID" id="18471635"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33204"/>
    <dbReference type="eggNOG" id="KOG3851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_2_2_1"/>
    <dbReference type="InParanoid" id="I4Y9C0"/>
    <dbReference type="OMA" id="YRCAPAP"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM20562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="438" mass="47695" checksum="08F2B4E2ACB882C0" modified="2012-09-05" version="1">MFSRRVLGLTPRLTRGLATPANNHHKILIVGGGTAGVTAAAQIQNKFRDENKSLGAGDIAIVDASKEHHYQPGWTLIGSGLGKKEDFVRPESSIIPKDVAHIPAFVQSFSPASNTVTTATGETLTYDFLIVVAGLKINFAGIKGLEGALEDQGSGVSSIYNPDYAQKAWRDIEAFKSGKAIFTQPAGVIKCAGAPQKVMWMANSQWNRSGTRNDIDLTFATGTPAMFAVPKYSQALEKLRLERNVNGLFNSNLTEIDTANKIAKFAQPEGKTVEKEYNLLHVVPPQGPLDFYKNSPLADESGFVSVDKSTTQHTKYNNVFSIGDCSSLPNSKTAAAITAQSPVLVHNLRNEMEGKSLNAAYDGYASCPLLTGHGELLLAEFKYGGIPKETFAPILGSQDKPNRFYYHLKKDIFPPVYWNYFVKGNWFGTRGPIAPNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9C3</accession>
    <name>I4Y9C3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WALSEDRAFT_20394</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959322.1">
        <property type="nucleotide sequence ID" value="XM_006959260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9C3"/>
    <dbReference type="FunCoup" id="I4Y9C3">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9C3"/>
    <dbReference type="GeneID" id="18470839"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20394"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y9C3"/>
    <dbReference type="OMA" id="SVFIGAW"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000002">
        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EIM20565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="846" mass="90686" checksum="B2726A9EA9245C48" modified="2012-09-05" version="1">MATPTFIPLLDKASGDDLLSSATRITPVLIPSEQSDRITSIPKSSKYYVLVRDDEGLDKAISYLDNGASAIFASLNLADSCISAGVPSEKLYAVANNTDIPEDILKNVKGALINISNTASTTQLPKPKVTFYLDESKALPSEKTVAELHSSRSAIVIPLSQLTNESTSSSKLNITDAFLAPITTDRPDGLFATIVSSYLHGGKSLGLCYSSKQSIEESVRTGRGVYQSRKHGLWRKGETSGAVQDVVKIELDCDSDCLNFEVVQHGTGFCHLDTPTCFGQLSGLAALEETLVSRHQSAPEGSYTKRLFNDETLLRSKIMEEADELCAAQSKEDVAFEAADLIYFALTRCVSKGVKLADIGHALDKKAAKVSRRPGNAKPKYLQEAQAKNSPAPAPSTTQQPQPVQSGSEMIKMRSTKLDTVSPEERLQLLRRPVLNSGAMIERVRPIVEGVRGKGDKGLLDFISKLDKAELKIPIARAPFDEPTIQQDVKEAIDIAYDNVRKFHIGQMEKAPLVVETMPGIVCQRFARPISRVGLYVPGGTAILPSSALMLGVPAQVAGCKEIVLATPPKPDGSIAPEVLYVAKKVGASAILKAGGAQAVAALAYGTETVPKVDKIFGPGNQWVTAAKMFVSNDADAQVAIDMPAGPSEVLVIADKSANAAYVASDLLSQAEHGVDSQVVLVTVGLNEKEIADIEKEVDEQARKLPRVDIARVSVSKSLIVSTGDVKTAFDFSNDYAPEHLILHLEKASEKVELVENAGSVFVGEFSPESCGDYASGTNHTLPTNGFARQYSGVNTLSFQKHITSQELTKEGLDKLGPVVVTLAECEGLRAHANAVRVRLGLQPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9K7</accession>
    <name>I4Y9K7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_69577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959184.1">
        <property type="nucleotide sequence ID" value="XM_006959122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9K7"/>
    <dbReference type="STRING" id="671144.I4Y9K7"/>
    <dbReference type="GeneID" id="18475602"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69577"/>
    <dbReference type="eggNOG" id="ENOG502SC67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121574_4_1_1"/>
    <dbReference type="InParanoid" id="I4Y9K7"/>
    <dbReference type="OMA" id="ENHLMHR"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8459" checksum="F5C07DC3EB7275CF" modified="2012-09-05" version="1">MKDKEINKLEGFINVRPSKEELVERNILKDSQIAPSLLSKQMELERHQLEDNLDHAVSHRPTAEELQARGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9W0</accession>
    <name>I4Y9W0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959281.1">
        <property type="nucleotide sequence ID" value="XM_006959219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9W0"/>
    <dbReference type="GeneID" id="18474192"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60830"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y9W0"/>
    <dbReference type="OMA" id="GWWVLEF"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="123"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="640" mass="74058" checksum="F8E00A0F902569DE" modified="2012-09-05" version="1">MESGENSPTQLEQPIQLPQANQDSPAGEASQDRKPSLKERVKIAQETAKTNKEIVHVKDDQGRSYSVDINLEAQDTANFQNDKQLIINPPKQRNEPHSLYRGDNVAPKRLKAVRDHNKETGGRSIILCLDGTGDQFDDDNSNVVRFFRALAKDEPEKQVVYYQSGLGTYSTTKRANPVANKLSDLGDMAVGSGLGQHVRQAYTYLMENYRFGDRICMVGFSRGAYTCRCLAGMLYKVGLLPKGNIEQVQFAYDMYKDNSTHGFDQSKFFKSTFCINVDIHWIGVWDSVSSVGFYPRELPFTNDNHLVKTFCHAVALDEHRCKFKAGHWSHEEETEKRSDGWFHRRHKENKINFGEHNVNEIEEDDKDKEEEVDPWEKVEKLRQGLFTRIDELRQQTAKSRFNTKRVNVDSIDKSNPEIQSLLQQLYKLPVKHDSFADDEEEEIKHKTKVKEVYFIGAHADVGGGSVPNNTRNSLARISLRWMFRQAFKAETGIIFQTHLLDYHGLDIGTLYPIVKPRPEAHYKVPDEFPQMPNLKDVPIERYDRSKLSEEDEDVLDSLSCINDQLELSKIWWLLEYYPQMEVYQDGTGKFRKRFTMNRGNYRAIRGSNVKFHRTVDIRQKALDYQIKARMQDSSEARWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA91</accession>
    <name>I4YA91_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_65041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959142.1">
        <property type="nucleotide sequence ID" value="XM_006959080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA91"/>
    <dbReference type="FunCoup" id="I4YA91">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YA91"/>
    <dbReference type="GeneID" id="18474985"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65041"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_2_0_1"/>
    <dbReference type="InParanoid" id="I4YA91"/>
    <dbReference type="OMA" id="KWQALET"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="96"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="282" mass="31424" checksum="4BB40C84C758D7EB" modified="2012-09-05" version="1">MVSLNNTLRERYEELRVLLDRAIEYYKALSTTSKILLWAVAGLHQILGVVIWLVGPKKIFGYIANIALELQNLPFGWLILVSCLVVASFPPLIGYGMLITVCGFVYGFPFGILPAAAGSITGATVVFQLSRALQKSAFWSSRLSALSNSPKWRAISLAITERGIGLVVLLRLCPIPPWVYSNLGFSLLPEEQLSYWNFLLATLLSTPRLFLHVFIGSRLFNLSDPNQELDGTSKMIDIASIVTGMTLSTALGWYVYKTTMRKIKESVHDVYDDNESLLSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAE4</accession>
    <name>I4YAE4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958930.1">
        <property type="nucleotide sequence ID" value="XM_006958868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAE4"/>
    <dbReference type="FunCoup" id="I4YAE4">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAE4"/>
    <dbReference type="GeneID" id="18474072"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60645"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_1_1_1"/>
    <dbReference type="InParanoid" id="I4YAE4"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="147" mass="16140" checksum="58A9FC9679C3CCA6" modified="2012-09-05" version="1">MQSENGEQVEVPQEEVEVAEAAPAGKMSVEEALQQVLKNALYHDGLARGLRECAKALDRRAAHLCVLVETCTEAEYIKLIEALCAEHKINLIKVSDAKVLGTWAGLCKIDREGNPRKVVGTSCVVVRDFGVESEGLNVLLDYFKSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAL1</accession>
    <name>I4YAL1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_64900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958991.1">
        <property type="nucleotide sequence ID" value="XM_006958929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAL1"/>
    <dbReference type="STRING" id="671144.I4YAL1"/>
    <dbReference type="GeneID" id="18474966"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64900"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005417_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAL1"/>
    <dbReference type="OMA" id="WILNTRI"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="9">
        <location>
            <begin position="476"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="933" mass="104515" checksum="28A6BE3B7914D4E3" modified="2012-09-05" version="1">MSTVEDFMNKERLEAIQSGRSIDHPHQQNKPGISLISDTLNSLRIQSARKLPTKFISSPSSTITPSVDGKYVFVANQSSIEIHNHSHLIHTINNAHNAKITSIQTLHYDKHKIITAALDGAIILWDTLDFSPIKHITYYSPISHLLVQQSQSDRNQTILFIALNKIAQRSRAADGSDRPPVINTVYYKYTWSHNKSVKKQSLLLGQTRPPTSVNLNDDILTAQCGKKLNVSQHNLVDKRSFVKWVNPEKQMQAALDPLNEFYVTSELSSGKIHLWPYSVIASELPAKPQVYSFNHPGFQNNCPTEVLHWHSHPIKALTFTPNGSFLLSGGDEGVLVRWHVRQTNGRLAKKDFLPRLGAGISYIVCNDETNWIVGLVDGSKVYVDGAQWRVDHVVRGLVIPSVPNHHERIPITNTHDGKLIFPSSHPSVLQIYDINNNTSEELEVSPNNRIVNKGDFHDNSQFNIQGRVEDVSSCRDWLATVDSASVKIWQIDQESGKYQLNTRIDKPHGDSAVTQVSWSNSSKGVPVLATIGEDRKCRLWRAEPLDYRPKALGKIKSIIREGQVSFSLFATLNYKDEEMNNVFFSPDSSLLVMVHPSTISLWNPTAVYTGKNAPSLLRVLSGEGVTLNEGVFVGSSYIAVRATAGAGEACHGVCLVYNLTNCKCIYTHSFAYTTPQILAHSSANKFALFSGATRPRMNTQDNEKEAEREKVLSKSAIATQMTTFTITNEGLIEREEVTEFDNSYFKFAFMPLSEGFNLVGLATTHENRVRNFAHSQTYVMGSAGAVLIGDQASKFDLRRDEIKQDQSGNMFEEIFGKFDDHLALFRDNEMEKDNAFINANEAGSKRTIKNLFDGPSHLLPGPEMLYGDFLEGFLPKRVNNVDDSKTTSIIYEDTPNGDIKMQEDDISGAEIQRNRHIDSSEVKLMTQLFREII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAS2</accession>
    <name>I4YAS2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PDJA1 chaperone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_46419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958749.1">
        <property type="nucleotide sequence ID" value="XM_006958687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAS2"/>
    <dbReference type="FunCoup" id="I4YAS2">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAS2"/>
    <dbReference type="GeneID" id="18472383"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46419"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="InParanoid" id="I4YAS2"/>
    <dbReference type="OMA" id="PADMHLH"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="394" mass="43359" checksum="3D33E0478D3F3518" modified="2012-09-05" version="1">MVAETELYDLLGISPNASQSDIRKAYRKQAISCHPDKNPNDPAASDKFQKISNAYEVLSDETSRESYDNFGTADNSHAGPPMDDFMNSFFFDLNRPPPAPKAKDQVVDFDVTLEDLYNGKSVHFAIEKDVICKLCSGSGGKKGAKPQTCGRCSGKGHVLSSRQLGPGLIAQMPTPCPACEGEGVKIKDKSKCRKCEGHKTTKAKKKISFDIKKGMVDGQRIRLQGEGDEVPGAKPASLVFRLRTKKHDTFRVSGYDLAINIKLTLLEALSGFEKIICHHLDGRTVKVSVPQGRVIQPNETLCLRDQGMPLSRGFGDLYVQCEVEMPSGYWMKLQDRNALAKLLPNPDPKNAIQEGEKTENVKYETSSMSNFGRTHAPPPNDFDDDGPSTQCTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB14</accession>
    <name>I4YB14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_46598</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958829.1">
        <property type="nucleotide sequence ID" value="XM_006958767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB14"/>
    <dbReference type="FunCoup" id="I4YB14">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB14"/>
    <dbReference type="GeneID" id="18472389"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46598"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="InParanoid" id="I4YB14"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="246"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM21156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="694" mass="74968" checksum="6E9DF3A35316FE97" modified="2012-09-05" version="1">MNPNARSFNFNPSASGFVPSWATPPQAQQQQQQEQQYTQGYPYAQQGGYGGYPYDQPYNPQQGYAGYAPPAMQPQMPEQPQQPQRLSAKEQMEMMSGSGGGGASQPVSLSLGGAPAKPSAKELLERKSDTPAKSMSISLGGAKPKPAEKPAAATKEAPKEAPKAAPAPKAAPASAAAPPKAATPQPKSASPAPSKSNDTSGTSTPVSKSAILAAQGKTDTIIKESRAAADAETLKDLFGADGVQPKQHLNVVFCGHVDAGKSTMGGQLLHLTGMVDKRTLEKYEKDAKEAGRESWYLSWALDSTPQEREKGKTVEVGRAFFETEQRRYTILDAPGHKGYVPSMISGAAQADVAVLVISARKGEFETGFEKGGQTREHVVLAKTAGVQKMIVVVNKMDEPTVQWDKSRFDEIVTKLNPFLKGSGFNLKTDVTYIPVSAYSGDNIKEPVSKSKVDWVEGPALIPFLDSMPLVDRNFSAPLMMPISEKYKDMGTMVVGKIESGTLKVNDKLTLMPNRDQVEVMSIENEVDEPVPIALCGDNVRLKLRGVDDENVQVGFVLTDPKKPVKTVRQFEAQLAILDHKNIICAGYGAMMHCHTLAEEVNLAALLHYYDKKTGRKSKKAPQFAKKGQKIVALLESTGPVCVERFNDYPQLGRFTLRDEGKTVAIGKITKLIEKTETGELADVSTGVQDMAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB33</accession>
    <name>I4YB33_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_69322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958848.1">
        <property type="nucleotide sequence ID" value="XM_006958786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB33"/>
    <dbReference type="FunCoup" id="I4YB33">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB33"/>
    <dbReference type="GeneID" id="18475569"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69322"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="InParanoid" id="I4YB33"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="16393" checksum="CE16B9E2210528F0" modified="2012-09-05" version="1">MVVHSFYIFNKSCQCIHSQRWQHYQQPAKDLSEEEEQKLIFGVVFSLRGLVRKIAGNDDEHFQTFKTSQYKLHIHETASNLKFILITDRDSPNLTKYLELIYAGPYNSAVVRNPLVNMTDERVTNENLRKGVEYIVKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB70</accession>
    <name>I4YB70_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958884.1">
        <property type="nucleotide sequence ID" value="XM_006958822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YB70"/>
    <dbReference type="FunCoup" id="I4YB70">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YB70"/>
    <dbReference type="GeneID" id="18474067"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60632"/>
    <dbReference type="eggNOG" id="ENOG502QT5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003840_0_0_1"/>
    <dbReference type="InParanoid" id="I4YB70"/>
    <dbReference type="OMA" id="VHIRRTH"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
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            <end position="473"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <dbReference type="ARBA" id="ARBA00004186"/>
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    <sequence length="1179" mass="130687" checksum="83C2CC2600B140C8" modified="2012-09-05" version="1">MEKLADQKERIRDAARAALMALSIGTLKFGSQSQSKLQSSAKSSVSSSSTKDAPETPWTILEKALREQGLGGKAWRIREQTLLHLSTLHPLQSFPLRTFLSPFVILLEDSDASVREAARSTIITLFRNSSAQAKTSLRKEITDKGIRKNVADEILDGVLKSATHKPELIPMPIDDPIEEVKLAGSNPQLSGISSRPQSSFGFNRAPTAPAPTSQASNSSEIEKLDPVYVASGKDLEKEFESMHILFSGKETEQNWIPRETQIKRLRGMLRGEVQQQYHDIFIQGVKHNVDGIIAIAGSLRTTVALNAINLCVDLSHFLGSSMDSFAEPIVSCLMKMATLTKKIVVQHSQSALTTILRNVSYSARILNVLYNAIQEKAPTPRQFAIMHLRVVIETHARAHKTFIETSNGLQTLETSIKKTLGDANPGVREQGRTTYWSFQNIWPAQSAKLIDSLDPTARKQLEKAKNAGNPAPAAKKSGLASRSQQFKEAKAAFIARNKTGPLPESTIPLPDTPEKRKTAAVHEDVESRSATPIMKRTPPRDEPLQQEDFEQGSQIEETERTERIEPEVVEQEPVGQIEQEEPAEQIEQQETIEQSEQIEQQAPVEQLEQDHQVEEVGEEENIEEAAPPASPMQIGSPPAKDHYDDEEMTPGSPTPLKLSNRGPSRSTSPKESSPLRQSFNLNDSTSTVNTSKPYGSPPHRPSPLGQTQPYQTRRPSERLSVAMMGSQNTPFGSLMQESQPDDWQNNSAMEDTFLLGNKSKNDTIEVQDEDEELEVMKFDDSPLKLQRSSNKRPLKMSASTRSSQTEGTPKQFNKEVENTADNIMEDLASTRISNTGEGAGEDDNEATPVKPIAPAVLNTSMRQSHATPPSKMRKILQQAQQVVDSPMNKAGTPKVMKDIQKVGGTNQWWLNKIDSYDNKNSNLLDSKYEQHLDILERLKEKLVGGDSLSQVELDQLNTISVMYPVTSDKENDNSIWSGGDIFTSILEGSLLMLDDTNLNADQQDATLRLLRNLIDKQSDLLIGSEMSVFNSLIKLRLSSRKENYDASDALMELFTDNIDPICGVGALESAIEINSNTTSADGMKTAMSFSLALKALGRLFLRLPSEVLEEEIPRVQDVLMKGLNYENGLVRQSTVKVIVAAQSILRDETKLFDLARIPESKKGILTYYINRVGLHNNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBD8</accession>
    <name>I4YBD8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_60502</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14"/>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958633.1">
        <property type="nucleotide sequence ID" value="XM_006958571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBD8"/>
    <dbReference type="FunCoup" id="I4YBD8">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBD8"/>
    <dbReference type="GeneID" id="18473990"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60502"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="InParanoid" id="I4YBD8"/>
    <dbReference type="OMA" id="IYTRCYS"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="152"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM21280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="38549" checksum="BE4B4165D6B3450D" modified="2012-09-05" version="1">MVLFNAAQSTKKVVNVALVGPGGVGTSVLEQLSKLEQFKLISITNSKGTYFNESGIPFASAKSELAKASPKCLEKEVIPALAKQQPCIFIDNTSSEDVAKLYPVALSHGVHVVTPNKVGFSASLSLYNHIKETSAASGAFAYKESTVGAGLPVISTLETLLKTGDKVTKIEGVLSGTMSYLFNTYSKSGKNDDILFSKLVSDARDQGYTEPHPGSDLSGSDVARKLAILSRHIPGLENALPDGVDSVDVQSLIPAGLDGDISPEDFLSGLKNHDAHYESLRKTANDNDSVLRYVGVIDAASGKIKCGLETYPSSHPLASLTGSDNIFLFHTERYGARPLIVQGAGAGSAVTAMGVVGDCITISERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBI8</accession>
    <name>I4YBI8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_18967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958578.1">
        <property type="nucleotide sequence ID" value="XM_006958516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBI8"/>
    <dbReference type="GeneID" id="18470787"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18967"/>
    <dbReference type="eggNOG" id="ENOG502SBSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2256608_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBI8"/>
    <dbReference type="OMA" id="HAKIAYR"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11600" checksum="8CA6379DFB61E86B" modified="2012-09-05" version="1" fragment="single">LISLSSISTSCQHPDIVKNVLDVDKELKPDFVSRSIEVQGSNLITTFEAVSLRTLRTSTNAFLDNLKLVIQAIDTFDAPNYRPTDVPEIKEGSKERDRHGVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBM5</accession>
    <name>I4YBM5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_60549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH668233">
        <property type="protein sequence ID" value="EIM21367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958714.1">
        <property type="nucleotide sequence ID" value="XM_006958652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBM5"/>
    <dbReference type="FunCoup" id="I4YBM5">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YBM5"/>
    <dbReference type="GeneID" id="18474021"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60549"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBM5"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM21367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="215" mass="25079" checksum="222D646ACFDAE4C2" modified="2012-09-05" version="1">MNLFRFLGDLSHLTSILILIHKIQQSRSCRGISYKSQLLYVIVFLSRYLDLFWTYVSLYNSLMKLFFIASSSYTLYLMKFKFRPTMDPSIDTLSLPYIIVPSILLSLIFNYADKDAWLSEVLWAFSIYLESVAILPQLFLLQRTGEAETITTHYLFALGAYRALYIPNWIYRYATESFVDPIAIISGLVQTALYADFFYIYFTKVIKGQKFELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBQ1</accession>
    <name>I4YBQ1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_54524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958427.1">
        <property type="nucleotide sequence ID" value="XM_006958365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBQ1"/>
    <dbReference type="GeneID" id="18472678"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54524"/>
    <dbReference type="HOGENOM" id="CLU_1143310_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBQ1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="27823" checksum="7A3CDA547DDAC96B" modified="2012-09-05" version="1">MRFKVQFREAGNLIEYYKNRTLKQRDLIERATREISNLNELKRENSSLKCEIQSLKDRLAYVYNSKPSFTIDSSNNDKYVSNYKTKSKPAFFSTSKMNNVNRTNTLMNYGVSTKRKDLSNSISSRSSSFTLPQFNDQIKLIPGSRKKISSDREIINKRHPERSVSQLSKFTSKIGFEQDIISIDDDSNGTKSKPNYDKGSTSNRLSSFSFNGRDDMSNSAISSLAKYQRGTHNKKVKNTNNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBX2</accession>
    <name>I4YBX2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958494.1">
        <property type="nucleotide sequence ID" value="XM_006958432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBX2"/>
    <dbReference type="GeneID" id="18475513"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69034"/>
    <dbReference type="HOGENOM" id="CLU_1836674_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBX2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="140" mass="16511" checksum="2F97C926330C85B6" modified="2012-09-05" version="1">MDASYKPRKKSIKRLNYNLLSLLAFYFFRDYLDFIQIDYIRLIFKWLPLLFIFNSIQSLIVLFSKDSKPTPQQTRNQIFETSTPKSRKKTRVDSVDIPLSENFTSSTPTKQISTPKQQSPKISTNTPQYAYLQKYPNVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC07</accession>
    <name>I4YC07_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_28834</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958528.1">
        <property type="nucleotide sequence ID" value="XM_006958466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC07"/>
    <dbReference type="FunCoup" id="I4YC07">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC07"/>
    <dbReference type="GeneID" id="18471061"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28834"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_3_1_1"/>
    <dbReference type="InParanoid" id="I4YC07"/>
    <dbReference type="OMA" id="QNHTGHT"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 20" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="19">
        <location>
            <begin position="316"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="539"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="672" mass="75863" checksum="B20066D39E79BBD3" modified="2012-09-05" version="1">MSVQEEEKRAEDTFKILLCTDCHIGVHERDPIRGNDSINTLKEILDLAVQYDVDFVLCAGDLFHEHKPTSQSVIQTMSLLREYCLNDRPVSIQLLSEPYDEQRPDISYPAINYEDTNLNVGLPFFLIHGNHDDPQTVPNWPSGAPSLSAVDHLATAGLVNYFGKVQVPPLDDVNADALDNDTGINVKPILLQKGTSKLALFGIGNIRDQRFNQELKNERVNMYAPLEDADDYFNILLIHQNRINRGALQAVPEHLFDDSISLVVWGHEHDCRIVPEIVSEKPYRITQPGSSVATSLSEGETVPKHVGLLEINDKDYNLTPLPLKTVRPFVMMDVNLREVEETQGLKFEDKLQVNKYLRQQIEELITRANEEYAERHQGVDAPSMLPLIRLRVDYTGFEIGNPQRLGMEFSERVANPKDLVHFTKKRQMKAKSQVVADAPEFRDDDEENAVVDNTGKLRVEKLVNTFLQAQKLQLLHEDGLQRSVESFVEKNDTHAIGDSVEKMVEHAVEYMSKQTLNDVDEEDDIEKAKEYAAEKYNVGKKTTETTGRSGRGARHGADSMEEDSSDEPAPTATTRGRGRGRARARGRAASTSTRGRAASARSTHDDDEELFHSSDDSVQETAPSRAKSVSARNQALSSQPSSRVPQRRRRNQEVYDVSSEEDDSRYRQKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC10</accession>
    <name>I4YC10_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Pzh1</name>
        <name evidence="10" type="ORF">WALSEDRAFT_46138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958531.1">
        <property type="nucleotide sequence ID" value="XM_006958469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC10"/>
    <dbReference type="STRING" id="671144.I4YC10"/>
    <dbReference type="GeneID" id="18472378"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_46138"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC10"/>
    <dbReference type="OMA" id="LYESNER"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="254" mass="29398" checksum="00DE05D9322BA335" modified="2012-09-05" version="1">MSGFPPKSNYLFLGDYVDRGKQSLETILLLLCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRSNVKIWKQFVDVFNSLPIAAVVASKIFCLHGGLSPNLTTMDDIRRIQRPLDVPDYGLLNDLLWSDPSDTAYDWEENERGVSYCFGKSVINDFLSRYEFDLICRAHMVVEDGYEFWNDRTLVTIFSAPNYCGEFDNFGAIMSVSQDLLCAFELLKPLDSQALKKEMHKSRKRRNQQQIANSNENVPTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC16</accession>
    <name>I4YC16_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_18867</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958418.1">
        <property type="nucleotide sequence ID" value="XM_006958356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC16"/>
    <dbReference type="FunCoup" id="I4YC16">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC16"/>
    <dbReference type="GeneID" id="18470781"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_18867"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="InParanoid" id="I4YC16"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="233"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="570"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="753" mass="82310" checksum="F26DA908D775E364" modified="2012-09-05" version="1">MLDNYDSFTYNLYQYLTISGANIVVARNDKITVAEVEALHPKNIVISPGPGHPTTDSGISRELIKHFAGKVPILGVCMGMQCMFDLYGGQVSHAGEIIHGKTSAVKHDGRGLFKGVPQDIESTRYHSLAPELTSFPPELALTASTSLSGVVMGLRHREYTVEGVQYHPESILSEGGRMLLENFLKLKGGTWAENPEFGIGDEQPPKVEAEKTVNGVGAIASSNQQKEKLPTILEKIKQQRLLDIQESINTPGKSHFNINECLQLDLAPPQINFSDRVKANKARPAVMAEIKRASPSKGLIAPNANAATQAKSYALAGASVISVLTEPKWFKGSLEDMRMARNAIDGLPNRPAILRKDFILDIYQIDEARLYGADTILLIIAMLSKEKLIELFEYARSRDIEPLVEVNNSEEMELAISIGSKVIGVNNRNLHDFNVDMSTTSRLADMVKDRDISLCALSGITGRKDVEVYIDQGVNAVLVGESLMRSSDPAAFIRELTNTTKPEVKYNGPLVKVCGISTITDALVAKDSGANLIGMIFAEGSKRKVTIQQARDISLAIKNSTASAVNFFEGIHDSDDTDTWFDYQAKLIERASRLRPLLVGVFQNQPLETILEAVQSVPLDVVQLHGNEPTEWTRMIPVPTIKVFHVSGKNSEMRNLRQSGYHSLSLLDTAVGETGMSGGAGKAFDWEIANQINSSRLNAIPLIVAGGLTPDNIQEAVKKCKPWAVDVSSGVETQSKKDVVKIVEFVKKAKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC49</accession>
    <name>I4YC49_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_51531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958563.1">
        <property type="nucleotide sequence ID" value="XM_006958501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC49"/>
    <dbReference type="STRING" id="671144.I4YC49"/>
    <dbReference type="GeneID" id="18472562"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_51531"/>
    <dbReference type="eggNOG" id="ENOG502RZ4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048587_0_0_1"/>
    <dbReference type="InParanoid" id="I4YC49"/>
    <dbReference type="OMA" id="HIQTYWK"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="329" mass="35996" checksum="61A3745E3E325FC3" modified="2012-09-05" version="1">MWRVTSVSVAYLYLIAIVQPILGVDIRSVQFLSKGIPISGNLYIPDNIETDSSLPGIVVGHPWGGVKEQTAGLHARQLAEHGFVTLAFDAATQGESGSGTLPRLIEDPYQRVEDIKNAVTFLSVQDSLVDSERIGALGICASGGYVSFAAQTDKRIKAIATVSAFDVGRITREPFGGGEIQYDTLNDSLKSASNNRTGIEKGAPPTIAWNTPNSTVTFTPETPTLYQEGYEYYHTPRGQHKNAPMLYVPESVDLMATYSSFAFVDLIAPRPYLMIAGSIADTLYFSRDAIERALEPKELFLVENATHIDLYDHLDVTLPKLVDFMSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC72</accession>
    <name>I4YC72_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_32479</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958263.1">
        <property type="nucleotide sequence ID" value="XM_006958201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC72"/>
    <dbReference type="FunCoup" id="I4YC72">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YC72"/>
    <dbReference type="GeneID" id="18471499"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32479"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="I4YC72"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM21564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="561" mass="60863" checksum="A73F7720EDFE7656" modified="2012-09-05" version="1">MVLAGLGRQLNSALNSFNKSQVIDEKTLDGLLKEISKALLESDINVKLVGNLRNRVKTRALKEFKDTNASGNQQKQIVQKAIFDELVALVDPQEEPYKPTKGKTNIIMAVGLQGAGKTTSCTKLAVHYQRKGFKVGLVCADTFRAGAFDQLKQNATKAKIPFYGSYTETDPVVISEAGVQQFKKSKFDVIIVDTSGRHKQEEDLFEEMRMISQAVKPHMTVLVMDGAMGQAAESQASAFKESSDFGAIIVTKMDGHAKGGGAISAVAATKTPIIFIGTGENLHDIDTFRPRPFVQQLLGMGDMQGLLEHVQDVAMSDPDKQKELAKKFEQGSLSIRDWAEQIKNVTKLGPISKIAGMIPGLNADMIGQGGDDEASKRIKRMLFITDSMTEKELDSNGTIFLRKGKDGKFVGMSRRALRVARGSGTSVREVEELLVQYTMMKSGILNMMKGQAGGMKPGQPGMPSRDQIQQMQKMMPPQLLQKLRSGGGPEILQQLQRGQIPKGMDPEMMEKMAQQMGMNPNAMGGMPQLPGMGAGGAGFNPASMLGGMDFSKMAGMFGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCH6</accession>
    <name>I4YCH6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF59-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668231">
        <property type="protein sequence ID" value="EIM21668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958357.1">
        <property type="nucleotide sequence ID" value="XM_006958295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCH6"/>
    <dbReference type="FunCoup" id="I4YCH6">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCH6"/>
    <dbReference type="GeneID" id="18471517"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32555"/>
    <dbReference type="eggNOG" id="KOG3381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075876_3_1_1"/>
    <dbReference type="InParanoid" id="I4YCH6"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM21668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="182" mass="20343" checksum="5CB674222C89B174" modified="2012-09-05" version="1">MSDDKINANPIIHEISHSNGSAYDTSDPWSTDFLTSEDGNNDLKHAHLDLDKAVEEGIDNDEVFELLKDINDPEHPLTLEQLAVVSKAQIEINDEESEAVILFTPTIPHCSMSTLIGLCLRVRLLRALPPRFKVDVRVREGTHQQEDAINKQLNDKERVAAALENNHLIDVVQQCLSSATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCN9</accession>
    <name>I4YCN9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958042.1">
        <property type="nucleotide sequence ID" value="XM_006957980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCN9"/>
    <dbReference type="FunCoup" id="I4YCN9">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCN9"/>
    <dbReference type="GeneID" id="18471467"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32333"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="InParanoid" id="I4YCN9"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="257" mass="29499" checksum="D15C19FD50ECEB76" modified="2012-09-05" version="1">MTTRIDINTHNQYNSPGVTRGDLKTDAIEQLTSWFEHAVKNGVPEPEAVNLSTVDSNGLPDSRVVLSKSINRLGVSFYTNYNSSKGREISANPFGALTYHWRYPHSQNNDGETQRQVRLRGRIVKSPLLESREYFHSRSEESRLGAYASKQSSILKPHSENDDGRDTLQSRLKDAREKYKGDDIPLPEFWGGYILVPFQIEFWSGRPSRLHDRFLYSRPLEQLQLQLPKDAITPIEDVDRMADELVNHTWSIDRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD26</accession>
    <name>I4YD26_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_68779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958169.1">
        <property type="nucleotide sequence ID" value="XM_006958107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD26"/>
    <dbReference type="GeneID" id="18475468"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68779"/>
    <dbReference type="HOGENOM" id="CLU_1344170_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD26"/>
    <dbReference type="OMA" id="NRNHDEN"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697707" evidence="2">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="204" mass="23496" checksum="3BF1DF1D138F6781" modified="2012-09-05" version="1">MKYIGTSYAVTTLLILGAVAQPIAQAGDARVGNTVQNHSLVGRHNDNAHYDPKKDNNNDNNKYGNHYNYDAKKYDNNPKPKQDNDDHKKYDDDKKKYNDDHKKGGQYNNYMKGDQGSGDKKYENDYKKDGNKYNGDNKYNDDHKKGGQYNNYMKGDQGSGDKKYENDYKKDGGYDHYKQGNYNNHKGDYNDNKVDGSNNDKKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD32</accession>
    <name>I4YD32_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_37988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958175.1">
        <property type="nucleotide sequence ID" value="XM_006958113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD32"/>
    <dbReference type="FunCoup" id="I4YD32">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD32"/>
    <dbReference type="GeneID" id="18472042"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37988"/>
    <dbReference type="eggNOG" id="KOG3118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019106_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD32"/>
    <dbReference type="OMA" id="EEYIRPQ"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="568"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="645" mass="73694" checksum="6788D701908BE82B" modified="2012-09-05" version="1">MARKRSHAQKKTKKHSSDNPKLDRWETADDIEKDSEDEFHHQNDMLSLGDTAEPSDDDSDNEQEVYALNNVGDSDDEEEIGDYQDVPDDAVEYSEEENDDDENQEDDLDDQKLKSWGSKQGAYYARQDENLSSDDEDDLNDHKLEEEEALKLQKNSRQDWNWEDVTGLDDADDDENTQEDTMNLDEPEVEEEPAVDLSGLSRAEKIAYLQKTSPETLALLTDYEDILSKIKETDDFIQKRKEEDENHPALGLLYVYHQTLLTYAPLLTYFICLKASSEYVNNRSKLLQHPVLKRMVTLREGIARMEDLGFGPGDEQQLPDEDDEEQEDIRNMIRQWAANKEQTEDMDDSWKDETLEDGELEGLMTDENAPPAKSKKKSKKSSKKGADVDSRNEMIHELDESALEYKPSTSAKSQKQKQRVSDDDYLGEADALSALDAQSKKNNKKTLRFHTARIAQTDSRRSAASKLRQSGDDDVPYRERKKARLEKGATSAPGEDLDGGDWTAQDEATRRQIMNEADLGETATGDDGDDYYELVRQSKKAAKQAKKEEYDDARWKSRVDYVDETGVDGPRHLPREIALNKAVTPARSFKHSKLNRNPRLKKRVRYDQAQKKLKSMKPVYQGGPEGGQYEGEKTGITRNVKSTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD82</accession>
    <name>I4YD82_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S15/NS1 RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_54428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958216.1">
        <property type="nucleotide sequence ID" value="XM_006958154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD82"/>
    <dbReference type="FunCoup" id="I4YD82">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YD82"/>
    <dbReference type="GeneID" id="18472671"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_54428"/>
    <dbReference type="eggNOG" id="KOG2815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063745_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD82"/>
    <dbReference type="OMA" id="ITHAPGI"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM21924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32813" checksum="6035DA2736128CCB" modified="2012-09-05" version="1">MNYFTILRNIQHPSRTFTSSAVNLVSKRKQQSRLKKKTNIARKQALIDAESSNLPSAALGYAPGQEDVWSNSELSKIMLTPHQVYNNIDNVSGRASLAEITGVPDDPSDAFPNLQIPKLLSKPMTKDDLLTVYKTLPSLSAQRGLGGSSLQSDLDIEKIILNEKEKLETFSRLIDLRNASAKGIMLENIRRCISVFGDDHINEKAKHPTHQGDSGKIEVQAAILTTRIRAIADHLHINTRDIQNRRSLSQLVQQRAKLLKYLKKQSLNRYESVLPRLGLTSKAIEMEIKGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDP8</accession>
    <name>I4YDP8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_60164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957894.1">
        <property type="nucleotide sequence ID" value="XM_006957832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDP8"/>
    <dbReference type="STRING" id="671144.I4YDP8"/>
    <dbReference type="GeneID" id="18473783"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60164"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159435_2_0_1"/>
    <dbReference type="InParanoid" id="I4YDP8"/>
    <dbReference type="OMA" id="FYGLYHQ"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM22090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="91" mass="10245" checksum="A485F0937A2255F1" modified="2012-09-05" version="1">MASVTQNVVRWSALATGVLYGAVHLRSVKNIQAKEEEHQAEKHHQELIEKARKAWDEKTASQSKSSNGLITDPENPSFDLEKFLEAKSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDV5</accession>
    <name>I4YDV5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_28381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957947.1">
        <property type="nucleotide sequence ID" value="XM_006957885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDV5"/>
    <dbReference type="FunCoup" id="I4YDV5">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDV5"/>
    <dbReference type="GeneID" id="18471038"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28381"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_1_1"/>
    <dbReference type="InParanoid" id="I4YDV5"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="218" mass="23648" checksum="BBB3CBC4510D7BAF" modified="2012-09-05" version="1">MSGLANYQKEFITTCLSNKILKFGTFTLKSGRTSPYFFNAGDLSTGELVLMTARAYAEAILASGVKFDMLFGPAYKGIPLVAATALILQSEHKINVPFAFDRKEAKTHGEGGNIIGAPFKGKVLVLDDVITGGTSIRHSINLIKNAGEQAEFAGVVVSVDRQEKGQGEKSAIQEVESEYGVNVFSVIGMTDIIKYLETTQADQALIDQMLKYRETYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDV7</accession>
    <name>I4YDV7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_32278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957949.1">
        <property type="nucleotide sequence ID" value="XM_006957887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDV7"/>
    <dbReference type="FunCoup" id="I4YDV7">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDV7"/>
    <dbReference type="GeneID" id="18471456"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32278"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="I4YDV7"/>
    <dbReference type="OMA" id="SGMCFTD"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="338" mass="37030" checksum="DC8F11198719D23C" modified="2012-09-05" version="1">MTEFKAYRGTESGKIVESTGKVGDIGSSDVLIKLTHAGLCFTDVHFIEAGIVLGHEPVGKVEKTGSDVKHLSEGDVVGYGYVHGSCDTCDECRSGNDTLCPSRQLYGETDTDFGGFGKYAKVNERFVHKIPAGMAPEHAAPLQCAGATVFSPFLKYDIKPIHRVGVIGIGGLGHLALQVANKWGCSVGAFTTSESKADEAKSFGAHDVIVTKRADGESFVPKSDAEKFDFILCTVSGQVPWDQYIDCLKPRGVVIPLGVDFGKFETNRYFSLLARENKVGGSFVATRFEHYKMLEFCARHSIKPAIEMLDLNEENINTAFDRLQKNDVRYRFVLKHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE66</accession>
    <name>I4YE66_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_59974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957522.1">
        <property type="nucleotide sequence ID" value="XM_006957460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE66"/>
    <dbReference type="FunCoup" id="I4YE66">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE66"/>
    <dbReference type="GeneID" id="18473662"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59974"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018495_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE66"/>
    <dbReference type="OMA" id="SVYRCKP"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="6">
        <location>
            <begin position="193"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="540" mass="59449" checksum="AC188B5273E2D83C" modified="2012-09-05" version="1">MTDYTKIHPESITEKNLIEVTSESLNSFVSDVSDDFFSPVKDLIKPEPAASKKGQFGPNGALYDGWESRRHNPTYDWAIIQLGAPSAKIKIIDIDTTHFNGNEAPYASVYATFAPNEDVKQNDARWFELLPVVPLGPSQQHAFEFEWTEPITHLQLRMIPDGGIARFRAYGEPTAVWPSDLTATCDLASVFVGGRVTFTSDQHFGKGANLILPGRGHNMGDGWETKRSRQAGHKDYVIVQLGAAGYIQYAEIDTCHFKGNFPARVAVEGIYAPEGPPTEYDTQGWTQLLPSQVSVGPHAQHYFQTSQAELLVTHVRITIFPDGGLKRVRLVGSRALPASVDAKSSNSSGTKNAVVDTPTKALPILPLTSSAFVEYGHVVQSYQDKSSTPPTIQTKRVNNGTATKFCNLSPLTNSYPEGTPANMNFCVYKCDPVDTSVGFTVEMLERHKYTTQSFIPMGDGGSRYVVIVAQNGSDDKPNMETLRAFTATSNQGITYKPGVWHHPMIALEKATDFGCLVYESGENIDCEEVKLDNLHYKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE70</accession>
    <name>I4YE70_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_17028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957472.1">
        <property type="nucleotide sequence ID" value="XM_006957410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE70"/>
    <dbReference type="FunCoup" id="I4YE70">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE70"/>
    <dbReference type="GeneID" id="18470717"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17028"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="InParanoid" id="I4YE70"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="110" mass="12801" checksum="B71B6E2AC7B1533A" modified="2012-09-05" version="1">MLFCPTCSNMLISQLDEESTNNKWVCAICPYQFPMTKQFNTRHKLKRKQVDDVLGGEDSWKNVDQTSAECPKCSNGRAFFMQIQIRSADEPMTTFYRCTNAKCANQWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE97</accession>
    <name>I4YE97_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_68281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957547.1">
        <property type="nucleotide sequence ID" value="XM_006957485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE97"/>
    <dbReference type="GeneID" id="18475372"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68281"/>
    <dbReference type="HOGENOM" id="CLU_832103_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE97"/>
    <dbReference type="OrthoDB" id="10464056at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="334" mass="37693" checksum="FA5705EBCA3B4691" modified="2012-09-05" version="1" fragment="single">MSRSVQLAVGISYTTNQNKRINYKSVDIPFNINVGDEWTEEDIIQRFKPRINLTSNVVSNTTVSVNGEPSNLTANIINKGNKKRSANGSQKRVVKPRNVGQPMTTRGKDKGKAKEMTQSTSADNSDSDSSNLTPPPPIIPATKDKPERIKKSTKTALATNAKLLAEDEIVSKHWKEFSHKTSADMIYLSEKTIPLSKAYFGETALEKQTNRQTHLVYKDDAIILLVQPNSTDVRLARIVSFDSLRAVRVRESKSRKPIFGFQLKKGTKVLNFLKLYGFNDDDWIHLFPNVNHELFLPDYESKLVYSLKVNAKKLDIDLEKLSDDQVTSIQKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEJ0</accession>
    <name>I4YEJ0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_32065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957632.1">
        <property type="nucleotide sequence ID" value="XM_006957570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEJ0"/>
    <dbReference type="GeneID" id="18471419"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32065"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="InParanoid" id="I4YEJ0"/>
    <dbReference type="OMA" id="FAECRPG"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="985" mass="108695" checksum="4E1FD0DA9F839F4A" modified="2012-09-05" version="1">MKANDAHTTPRVNLPSDNLNSRLLGTPTNSSTTNNRTHFPRTPFASYFGRSTESTPLLQSHINPPSPGQSYFGSRSLGMAINRHRNKSKKHGYDDLYENDMVESGKGVRTYAHTHTSIDYIHDKVKEGVRLRRLLRKKGIRGFLEKSFDRAQGWFIVTIIGIVTAIIAFTIVRTEAWLFSFRDGYCSNSWLKSKQFCCNIKYTSHQDNFSYLSASMPTLTTDCPEWTSWEDTFGKRSSTLLNWTMAIAFAFISSIITVYISASNAPWVNDSNSARLEAYHHAASGRKQSVSSPMSCSPQPHPSLHSHRDSISSFLYSNGTNKTNSLHSHSLSRKSSSDDDNSLYSDSDNFEEELQANNDEYADQFDTTNLLSTPTAEKLQLTSPHNYPVMYFAAGSGIPEMKAILSGFVIRGYLGVCTLLCKGIGLAFSVASGLNLGKEGPMVQIAACVGNITSRYIRKFETNEAKRREIISASCAAGVSVAFGAPIGGVLFALEEISTYFPPKVMWRAFYCASLAAVTLKFLDPYGTGKTVLFEVTYDQDWKFFELPFFFIIAIAGGLYGAYFSKFNIWWGKNVRMQSIVKSHPIIEVVVITLITAVISSYNPLTEMGGTELVSTLLSECPSKSSGKKLKGIFATLCAREGQAPWGIIKTLSLAIGIKSVLTVITFGMKLPAGIFVPTLAVGACFGRMVGLVIEYWSIVQPDSALFGQCKSQSKCMLSAIYALIGAASALSGVTRMTISLVVIVCELTGTLNYVVPTMLSILISKTLADTIEHKGIYDLIIDMNKLPFLDAKHEYRFGKDSVLDVATKKIPVIRIDQEHSVCTLLDKLDSLVMRGLSDSGFPLIIDDEGIIRLVGYIAANELEHALDSLSHNPSARVRFTPFDTLQNSILTQSTNNSNSNSRSRLTLFKRFSGVHDAPLSANPYDLSAYCDLSPVVVRPEAPMALVHDNFSKLGARQVFVVDSIGGFQGVVYRKRWIDYLKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEK7</accession>
    <name>I4YEK7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_17351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957484.1">
        <property type="nucleotide sequence ID" value="XM_006957422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEK7"/>
    <dbReference type="STRING" id="671144.I4YEK7"/>
    <dbReference type="GeneID" id="18470729"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17351"/>
    <dbReference type="eggNOG" id="ENOG502S1TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094315_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEK7"/>
    <dbReference type="OMA" id="MISCCTY"/>
    <dbReference type="OrthoDB" id="3349852at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27195" checksum="4A04C81F7AD9F521" modified="2012-09-05" version="1">MLKFIAQLIFVLLTLSAGVINIFVNISAISTDLVPSALKYITVDTSLLGQSLSSQNAELDSLYTTNSDDPLGQGLGVRQDYYFGQYAYCGTLEGRRDGVCLLGRDSGSEFISRLDPYTYIINDTPENLKDGVRSLLEAPDTTFTASDYLRRYSAAAYWLIFLSAIFTGVALFTGVVPTRYTFFFGGVFCLLAFLTVAVGAAILTALIAKIRHINGEALGVYVHFGVSLWLVWITAFVLMIATPFYFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEL0</accession>
    <name>I4YEL0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957649.1">
        <property type="nucleotide sequence ID" value="XM_006957587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEL0"/>
    <dbReference type="TCDB" id="9.A.55.2.2">
        <property type="family name" value="the tmem205 (tmem205) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18473710"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60050"/>
    <dbReference type="HOGENOM" id="CLU_1321813_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEL0"/>
    <dbReference type="OMA" id="PLTSKTM"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="22795" checksum="8CE7A96F4AE006B3" modified="2012-09-05" version="1">MENTVDDLHVNVPLFNKLAQAGQPSWPGLYALLTKNGGGFYLLLLGTLLGVQFWQSYIGAVITYKAKPFEARLASTYCIIGSTISSALLGRWIINHGHALDFGILCQTVKALDYHNLCKAVNSIHVDAFHTILLAKIALSHFIHLVFVGPATAELLQSRNRASNPEEVKCVDKKFTILRVISSSIDLVSLAMIVLHTLYIGYVGTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF85</accession>
    <name>I4YF85_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_36646</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957293.1">
        <property type="nucleotide sequence ID" value="XM_006957231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF85"/>
    <dbReference type="FunCoup" id="I4YF85">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF85"/>
    <dbReference type="GeneID" id="18471971"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_36646"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="InParanoid" id="I4YF85"/>
    <dbReference type="OMA" id="KEFTMQD"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="125" mass="13928" checksum="54D60E71A8C711F2" modified="2012-09-05" version="1">MTENKKYTIEDLKQHQSNEDMWLLINGKVYDCTKFLDEHPGGDEVIISEGGKDATEAFDDIGHSDEARSQLDSLYIGEFDGPSKVSSSSQTGTKSSDTRASLLSNILFPLVAISAYLIWRIYFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFA8</accession>
    <name>I4YFA8_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_63283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957315.1">
        <property type="nucleotide sequence ID" value="XM_006957253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFA8"/>
    <dbReference type="STRING" id="671144.I4YFA8"/>
    <dbReference type="GeneID" id="18474827"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_63283"/>
    <dbReference type="HOGENOM" id="CLU_1897831_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFA8"/>
    <dbReference type="OMA" id="ASAFRWY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="144" mass="16138" checksum="330A7346B98FFEE3" modified="2012-09-05" version="1">MDDGTLPTEKKFITIQISVREAKAILGVEGTPTVAGITSQYKKLALRYHPDKNPAEKQQEAAERFKQLVQAVQVLSDSLSSSSDTVDSPSFDFTTVFKDTPFFNAYMQDFTYTPPLQPSCPGPSQKAFRWYDPPKPQGHRNRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFH7</accession>
    <name>I4YFH7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_68153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957380.1">
        <property type="nucleotide sequence ID" value="XM_006957318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFH7"/>
    <dbReference type="FunCoup" id="I4YFH7">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFH7"/>
    <dbReference type="GeneID" id="18475356"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68153"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_1_0_1"/>
    <dbReference type="InParanoid" id="I4YFH7"/>
    <dbReference type="OMA" id="NEICWDK"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="82" mass="9435" checksum="D5B573D4DBD2EFF9" modified="2012-09-05" version="1">MDEATQRELNSFVEQEQAKAKLQSSTHTFTEMCWDKCITGSIGSRFSRGEETCLVNCVDRFLDTSLYIVKALDQQRQQVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFM1</accession>
    <name>I4YFM1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_59929</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957420.1">
        <property type="nucleotide sequence ID" value="XM_006957358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFM1"/>
    <dbReference type="FunCoup" id="I4YFM1">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFM1"/>
    <dbReference type="GeneID" id="18473632"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59929"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_0_1"/>
    <dbReference type="InParanoid" id="I4YFM1"/>
    <dbReference type="OMA" id="HWALGYH"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697930" description="Glucosidase II subunit alpha" evidence="12">
        <location>
            <begin position="20"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="14">
        <location>
            <begin position="87"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="377"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="16">
        <location>
            <begin position="713"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="15">
        <location>
            <begin position="822"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM22763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="949" mass="107732" checksum="C72C12882BB007D2" modified="2012-09-05" version="1">MRVTFLGILIALFLGIAECVKQNDFKKCQQSSFCRRLRSLSDRKTNSSVWESPYAITRGLEQLGDEAASYTWKLNNRLAPEGIAFDLAVDVLKDGLIRLRVDESGGLYQRYNQTASYILVDQPELMQASSVKITSYDDVDNLAFQTSTNQPMELKVYHNPLNVQLKNAQSGEILVDINGESLLHMEHFRHKDAEDTDNNSAFTWHSEQPFEDPNTDGLWEESFNNKPDSKPKGPEAFTIDINFPSHSHVYGIPEHASPLALPPTDGSSPRRVPYVDDPKPYTEPYRLYNLDVFEYEANSPMALYGSVPLMHAHSPRSSLAVFLLSAAEMWIDVKHPTKESTSTQWISESGIIDLFLIPGPTIEDVFSQYASLTGVSQMPQEFSLGHHQCRWNYFTSKDMLGVVSGYDSIDAPVDVIWLDIEYSDGHKYFMWDKKKFPDPVDMINKIASKGRKTVNIVDPHLSRDDEFYVFNEASDKEVLVKKPDGQSEYEGWCWAGSSSWVDMFNPASWDWWISLFKFDKWKDSTPDLFTWVDMNEPAVFNGPEITMPKDTVFYGGVEHRDLHNINGILFANLTSQALEQRQEKNSRSFVLSRSFFAGSQRFGAVWTGDNLGTWDHLRSATPMNLANNIGGIVFTGADVGGFFGNPQPEYLVRWYQTGAFHPFFRAHAHIDTKRREPYVLDEPYQSIVREVLRLRYSLLPVWYTSFRENTQTGLPILRPQFVVHPSDAGGFDIDDQFYISDSGLLVKPVVHEGAQSVDVYFAGEEPYYDYFTHEISLGSKHKGRRKSFFADLESLPLFIRGGSIIPSRQRARRSASVMSKDPLTLTIALDKNGNANGRLYLDDGHTFDYQDGAFIDRQFTFKSDRRGWTLTSSEIVPGDSYEDGNEVFIERIEVLGLKAPPKEIKVDGRPLEFSWEDGTAASSNKEDTASLLNIKKPLTKIAHDFKIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFR2</accession>
    <name>I4YFR2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_59951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957458.1">
        <property type="nucleotide sequence ID" value="XM_006957396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFR2"/>
    <dbReference type="GeneID" id="18473646"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59951"/>
    <dbReference type="HOGENOM" id="CLU_795011_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFR2"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="349" mass="39620" checksum="36AB99712FCAD780" modified="2012-09-05" version="1">MTPVAFISSEDERINEGEPFWINEMFPLNQTELDKFLNTVGKQDLNYTIYEVKTDSIVTGSQPKLKVDDMNKRDILSKTDRLLLIRASDSQTKSWFANYRAARFWHGLIANILVTVTGIGTFAWGMHHGDRDAMVTGMGALIGSAVLSQGFQSPQWPGSVENVNGELEGPNSAKRTSDSLDHLISHLGISKEEEISSIINQWEIVNGFHKHHMFSKKDELGRKQEFLLILEGATRERVRKLSKRDDQHIVYGVRYTYYYPNHDPALQAEYESSGYDADGMADFILGTMESLQSKETCVYLDIPESVLRMAGKMELLLYDYVDTGPSYDDCVNNYPCESSSTWCTRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFR7</accession>
    <name>I4YFR7_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_15846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956848.1">
        <property type="nucleotide sequence ID" value="XM_006956786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YFR7"/>
    <dbReference type="STRING" id="671144.I4YFR7"/>
    <dbReference type="GeneID" id="18470680"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_15846"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028567_26_0_1"/>
    <dbReference type="InParanoid" id="I4YFR7"/>
    <dbReference type="OMA" id="HDSICSE"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM22809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="194" mass="22326" checksum="0808F29BA5CF6009" modified="2012-09-05" version="1">MAPTHRSRNSSADNGDRAWSEEEDKLLLRLVKEYGSERGRRSSWPLIASYFGGKRTMKQCRKRYFYTLDSTITHGKWSREEDNKLLSLIDVFGHKWKEISFEMTGRTDDQCSSRYLNCLQCKKTPWTAEEDATLLNLYEVDGPLWTKISSSLPGRSALNCRNRYRKFGGKVYKARKLSASGSKKVCSHVLRAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFY9</accession>
    <name>I4YFY9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_62898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956930.1">
        <property type="nucleotide sequence ID" value="XM_006956868.1"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFY9"/>
    <dbReference type="GeneID" id="18474796"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_62898"/>
    <dbReference type="eggNOG" id="KOG2993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000795_0_0_1"/>
    <dbReference type="InParanoid" id="I4YFY9"/>
    <dbReference type="OMA" id="CISSTHL"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1653" mass="184503" checksum="E90A3B73B456B5AE" modified="2012-09-05" version="1">MPICHPCYLIDSCQSLLTQRRSMLWEWFKLPNIPQISQLPKEISKSLLDYLLRWTVGKYIDIDNALAEDGIDIYNRRLNTTSINSHLTSFPIETNSASLGRLSIQVPWSNLFNDPINVVIEDLHITFQPSTRSDTTDEPGITVDDLTEQYIENQDIVIPGSFDAPPAAVIDAESPSNQRTLLKSLINAILAKLRVNLKYTSIKFTEGVSDNGFDLRIGSLDYGDVDLDTQERKLKIDDIEIHSCGAPPDQSSQSQMFMSAQESLTLQTQQSQCILKLIDGITMKLCNNSLPTIEADFGRTLAVLYPSTISLILTLIEAFPPKTESSSNGADSVDSNDMFNLKASLKELRVLLLLDEVNQVINESDLWNGGDEAQIPGYFLDLNATNVNIKCTPECSLSVGDASILANDSVSTSPILVFDEAIAQVINEEFPRMSDWLAEDDGVNMFDHKSWKLLDRQTSQSEPPAVTMTRNDVKLSPVHFFVDLGIIERFFGSDLFKALDFTTKDHRHDSVVNSLLTEAEKQNDPSLSEVLTPLQKVPFLLTVSALRISVRCPPPLGQQSLRSGILAIDARCLKLTPNSTSTDVSVEWSNVNWLDARHIREKMQSIARIRESRFIIEKRKRQSPKLTFNVPFIELKFRKREVIGLQYLADDFAQFSERLKLSASGTSKKEDVMQSVVELVKSRLIVADETSTSAYVDDSMDDFFSAEASTHKDAASSLVDDTDIDINLEAGTYTIDVPTVNLNTGEETGDYATIVADARAVTLSAKFGNKSTKNKMTLRVIAAMLTVGEPNSDKIIESMNFNDRPALDLRFATYLSEKYVKSSTADVVLSSIVLNSNMQMNSITSLAKMLETPPGVFENAIPSDVTTLTVKLKDVSFRICPDVSKRRLVVNFGNTHSQLTLRPNSQANTVKIVSGNTSVHLIDDVTQMLDDKRDEEGSDVLVDCLRNYWKTKGYVHIAELVKLTAKTKLTKSQEEPKITADIFYADTRVGLCADSLSTLIKLLSDVSPKSSGTSNDSSIQSNDDKDPYTNLLASLDESAFKQLPDAIVAADLVDDDIPSNQEYIYETTTQQQERYLKEQTVDFDAFEEGLTPSSSDDLRDNVDDYIIPATSQPNEIVRQLIPDAVMQSNFIEALRNKLDGSVKVAIKPYMEVQLHSADTSLQLFEGCDWPATRHRIEEEHNRIRKKLVKFRQLLASGQQADGTEEELSFDVYGAYNVGISQHVNGNEEILKAIDEELGDESEWQTLVTPTHSRRPSENTSTRQADFRKSLYRSKGPFVEITACGVKSTMQKFEKEEKSSDIKLSIKDVEILDRKQKSNWRKFMTSLDKDLRGNVRESESNMVEISLDTLLTEGGEEEVALHSHVLPLKLNMDQDALDFLKRFFAFKDDTDANGDVEKGPYIRQAIVDPVEIKMDYNPKHVNYAALREGKTIELMNFFHFDGSEIILRKMMITGITGWSKLFEILQDTWTPDVKANQLSDVVSGVAPIRSLVNVGSGFADLVLLPIEQYKHDKRIIRGLQKGGSAFARNAGMEALRMGARLTNGTQVVLEHAESILAGKSSEDKLTMETVDEVSEPMTLRQGMESAYKSLNNNLNEAAQTILAVPMEVFEKGEKNKPIIKAVPIAILKPLIGLTTAASKIQQGFLNKYDKNDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG06</accession>
    <name>I4YG06_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TMS membrane protein/tumor differentially expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956946.1">
        <property type="nucleotide sequence ID" value="XM_006956884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG06"/>
    <dbReference type="FunCoup" id="I4YG06">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG06"/>
    <dbReference type="GeneID" id="18473492"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59674"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="InParanoid" id="I4YG06"/>
    <dbReference type="OMA" id="DKHCNPL"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="502" mass="54983" checksum="215732BBE7EEB34D" modified="2012-09-05" version="1">MACLPAIPFLGFASPIISSCVGALAFCCTSTALSAMFKSCNCNSSVATRIGYSIIFTINSLLAWLMRTRWAIHALEKLTYDYLKMDCPSGKCYGVLAVHRFCFALSLFHAILGLLLVGVKDTRTNRASIQNGWWGPKFMLWISLIVVSFAIPNDFFIFWSNYLALIGASIFILVGLVLLVDFAHTWSETCLDRWEDSESNTWKYILLGSTLGMYITSITFTILLLVFFTGSSCTLNNTFLSIHSVLIVAITILCIHPAVQDANPKSGLAQASMVAAYCTYLTASAIVNRGEEGASECNPLGGGSFASHTSTVVLGALFTLLAVAYSTTRAATQSKALVGKNKKRVEITGGEYEALNDNADVVSSQPKQSDNIRTQALMAAVEAGSLPASALDDAEAAEEEDEDHDAGELNENDDEKSGTKYNYSWFHVVFILAAMYVSMLLTDWNKIQSGSENENGDELIRIGRSPAAMWVRMISAWLCFFIYIWTLLAPVFFPDRFEGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG61</accession>
    <name>I4YG61_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_67837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956998.1">
        <property type="nucleotide sequence ID" value="XM_006956936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG61"/>
    <dbReference type="FunCoup" id="I4YG61">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG61"/>
    <dbReference type="GeneID" id="18475307"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67837"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="InParanoid" id="I4YG61"/>
    <dbReference type="OMA" id="GMNEHKG"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="720" mass="81051" checksum="FFFA91DABF0F6DD0" modified="2012-09-05" version="1">MDILNRFRQRVQENLAESTRDIEFGSNIRIADTPSDKLTDIVPKLSSNKDIEVIDALKRVLVLLSHSRDLSTLFPSIIKLISSRNFQIKILAYVYLTRYAKICPDLAMLSVNTFQKDSSHVSPLVRAQSIRVLSSISSEDVAPVCLLCVKRAAKDANPYVRKAAALAIPKCYELDESSYEDLRELALDLMTSSSSIPIGSAIYAFNKIHPEVENLNDSMFALHPVFRHLVRQLVECEEWSQLVIIDLLTRYSRMFLPKPEGDESIDKDLDDFLRICQYLLGSQNIAVTAKASKTILLLGTPSYKKKALRSLLRSRKDSPEMAMYVLLTMAHISESDPESIAPFLTCFFIVKDETLSIKVIKLNIIRNIMTYLNESQLIALAKELKCHMLDPDTTFAAQVIDTIGYLTHTTEKASEFAFKVLASSSVSSNKVLSQKSIIQLRNFMNNHIRQSFYLRKLLKRMFGGSIEDDDARAALIWIVSQIISNPPDDEVYNSGEDIIWKYAPDILRKSVLGFSEEGIKTQMQIINLAAKMMTSVPNVSEVHILARKVFMLSNYMVDVDSTNLKHLDAQNRRQALVNAVRGVIGTEEYSTDQMPRIVLRRLQASLVLDTSTKDPHTVDKIASLPQKANPVKIQDDILMDLLPEWSKDDLPSADVRMETYPKGYPEESTSTPTAKPGIEPVVPLKDSSEVVEIPEADEDMLDDDLEKFLDSDSSSNLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGI5</accession>
    <name>I4YGI5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="11" type="ORF">WALSEDRAFT_31703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM23077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957110.1">
        <property type="nucleotide sequence ID" value="XM_006957048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGI5"/>
    <dbReference type="FunCoup" id="I4YGI5">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGI5"/>
    <dbReference type="GeneID" id="18471358"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31703"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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            <begin position="5"/>
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            <name>ATP</name>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
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    <sequence length="263" mass="29169" checksum="BB27D1AF20E12BC8" modified="2012-09-05" version="1">MSGIKESAQQELEHLKSLVKDLSDKIVDLEQRSKAAVLPSGRTPSEELRMILIGPPGAGKGTQAPNIVNKYNVCHLATGDMLRSEVGKKTALGVEAKQIMDAGGLISDEIVVGMIKNQLETNEKCKLGFILDGFPRTVPQAEKLDDMLSSKKQSVDHAVELQIADQLLISRITGRLVHPASGRSYHKEFNPPKKPMTDDLTGEPLIQRSDDNVEALRKRLNTYHQQTTPVVEYYRKQNKHRPIDASQSPKLVWENLSAIFASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGP0</accession>
    <name>I4YGP0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pbs2p</name>
        <name evidence="12" type="ORF">WALSEDRAFT_31307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EIM23132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006956471.1"/>
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    <dbReference type="AlphaFoldDB" id="I4YGP0"/>
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    </dbReference>
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    <dbReference type="GeneID" id="18471279"/>
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    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_79_2_1"/>
    <dbReference type="InParanoid" id="I4YGP0"/>
    <dbReference type="OMA" id="RANSPHI"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
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    </feature>
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        <location>
            <begin position="131"/>
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    </feature>
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        <location>
            <begin position="486"/>
            <end position="506"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM23132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="506" mass="55396" checksum="2A019008489FEE49" modified="2012-09-05" version="1">MSAEDLQNLESSSEEEGEQDSNRASQSSSPSTSTAATRKKSIHGSASPSTPRLPSSLAAKMAAMVNRGSNGQANAGGQPIGSSLRSMRQAPLPPNQLKDKMEALSMNDKVKVEENNNPPPNSLAARRGMKLNINGPQSSNDASPAKRRGPPGKLNLSNQDGKADTPFSNFSSIVDPSGKLNFGEGKAILHASGVNFSTGHSFNIKIEDLELQDELGRGAYGSVRKAKHKSTGVVMAIKEIRLELDKTKLAGIAMELDILHRAVKPQIVEFYGAFFVEGCIFYCMEFMDAGSLDKLYSPTFGIPEDILAFVTRDLIIGLQFLKEELQIIHRDVKPTNVLVNRRGKIKICDFGVSGQLEKSLAKTNIGCQSYMAPERIQSPESGVHGGFYSVSSDVWSLGLTMVECARGEYPYTFQNVLAQLQEIVKGPAPELPSYYSDTAKEFIHSTLRKDPNQRPGYQELLEHPFLNQTNQPDVLKWIEDALRSKNDGNLPDSIPESEPSRHFDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGQ4</accession>
    <name>I4YGQ4_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_59457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956544.1">
        <property type="nucleotide sequence ID" value="XM_006956482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGQ4"/>
    <dbReference type="FunCoup" id="I4YGQ4">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGQ4"/>
    <dbReference type="GeneID" id="18473363"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59457"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085806_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGQ4"/>
    <dbReference type="OMA" id="KNIANTW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM23146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="258" mass="28364" checksum="672E900206B7E631" modified="2012-09-05" version="1">MDDWDASSSDEQPQKVAPVSAPAPARKGKWDDEDEDDKVEDSWDAPSEDEEKKKPAPTPAKKAPAAAPPKKKGTLKQKLEQKEKERKERMDKEGEIDDGDAIDWLEKQRAERQAAKEKEIASDLANAADLFAGMNVAPSTSQTLKKKPTKLAEFQQLAGAVQEVYFKPHASNPQYQQYVTTIVKNLADSLKENEIKGLATRLNTIAAEKARANKAAAAKNKKTKPSLGGGHTTSGTRLDTNIYDEALDDGDDDDLEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGV0</accession>
    <name>I4YGV0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud site selection-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_43194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956586.1">
        <property type="nucleotide sequence ID" value="XM_006956524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGV0"/>
    <dbReference type="FunCoup" id="I4YGV0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGV0"/>
    <dbReference type="GeneID" id="18472276"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43194"/>
    <dbReference type="eggNOG" id="ENOG502QSKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019711_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGV0"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="707" mass="80492" checksum="32D87F44AFA41D12" modified="2012-09-05" version="1">MSLEAPWLKDCPEFIELEIAESVASRTETLSTFRELGPPDLCHIIKSPTKVGTTKDSGSYHYVSGVDASSSASIAIYLNELLRSLDLPQGWFTPNAAWKVRSGTYCCYNAFSRLDVRVQVSIPGGVDSYAVDLRGQRHELSSDLWLETYLSAHLRAILYADDPNYKLYGYRKFDPIPKPEDEEKFLAASQHLFHKGWQLGSDPEIQVATPISNHLTTAILKYFGDSGRMSRAANLFEKIAESQRKTSGEKVGCEVDALTAKAYIGMNEETLAIRTLNRALNVSPQSWPLLHVQVDFLRSKGQHQWAVQLARQAVECSPSEFVTWAKLTDCLIDIEDFEGALLTLNSCPMFTYNERDLHRMPTPIKNHFPIQKWVIDSQLIEDDSPKENEADITLLRLPAPSLRGTFARAYELLTRLNNCIGWDDLLKIRSNVFVMEEEYRQHKSDDSTATIITSDNVSAQTQTQASNEVIKQPAIPTIKISSDSDHEREQFKKGGLELHMEDSRGNEGNTTDETVNETSETNDTNQSDNDSRGLSFSDKKLCERWLDNLMLVLYEDLRVLTIYKAERSHFKSQQMQYRKTGTEWEIIGDLCLRMHNKEDAKEAYQRCLDLKFSAKSFIKLLEIFANQGDTQRAFAAAIRLTAYNHRWYNTSVYPNAVSNQLFKIVRTEGVQKLKFMTMSLGNDLPIQSQLSKYWNYIESFKVEGEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGW4</accession>
    <name>I4YGW4_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956599.1">
        <property type="nucleotide sequence ID" value="XM_006956537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGW4"/>
    <dbReference type="FunCoup" id="I4YGW4">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGW4"/>
    <dbReference type="GeneID" id="18473385"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59490"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1143311_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGW4"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="243" mass="27485" checksum="55B505F99080550D" modified="2012-09-05" version="1">MLILVANELNIPTQSVGLPNQFKKLLQPNKLDGIIILGQMNDKITLDYFRSLCDKVIIGASGSTLMLDSFKVGLICDNQTQSYELTARKLDVDMLLIAGPKSFEAYERDSTFYCSPGSMTGTYSSLEEKEAIPSFILLDIQPDQVTVFVYSLIDEQIKVDKIEYSKEQDKPSEKTSQTNQAQPTEESTLEPEVQRQDERKEQEEQEEEGKQQVENDEDVQLPAESSRYEIAPAPAETDNLWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YH75</accession>
    <name>I4YH75_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BIR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_67589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956703.1">
        <property type="nucleotide sequence ID" value="XM_006956641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YH75"/>
    <dbReference type="STRING" id="671144.I4YH75"/>
    <dbReference type="GeneID" id="18475268"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67589"/>
    <dbReference type="eggNOG" id="KOG1101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_689286_0_0_1"/>
    <dbReference type="InParanoid" id="I4YH75"/>
    <dbReference type="OMA" id="SEHETRM"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="400" mass="45128" checksum="D86F1DCCC1F749B9" modified="2012-09-05" version="1">MEIYTKRLKSYNKTYHRNVAHLDVEALSKAGFYAMESKSDKVQCAYCDLKLSDWKEDDNASGLHLEFSPQCPYARVVCGIALDESIWGTEHGGKNRTEYYDDEPTQAGRVPRSRPMIDARKSTFVKCVRPLSVSVHKLALAGFYYAPTEDAFDNCECACCEINLSEWQKGDDPTEEHRNRSPNCSFFHAKVVKGTCPHKKVQNTQKDTTKKTATQKKGKSISRTASMTTDNGENEIVVPKRVTRTRSQSKQPEEIAPPVKEATTRRKTSRTVSQQKKAPPKSSKLEDLEESPKKSLPPTPKEENPTNNLSPLPELSNSNGIKSSRQLLNQFNKSPSRLKEVTNSDENSDRSLTLAEFIRKCVTDESNKMRQLGDSQIQKFESKAKLGEDELRAKLSQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YHP0</accession>
    <name>I4YHP0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_59228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956160.1">
        <property type="nucleotide sequence ID" value="XM_006956098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YHP0"/>
    <dbReference type="FunCoup" id="I4YHP0">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YHP0"/>
    <dbReference type="GeneID" id="18473234"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59228"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="I4YHP0"/>
    <dbReference type="OMA" id="MCLKVKY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM23482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="309" mass="34850" checksum="5F68B47A65150D18" modified="2012-09-05" version="1">MTVDPQQWLDTILSGKYLAESQIKMLCDVVLGLLVEESNIQPVSSPVTVCGDIHGQFWDLLELLRVGGDCRDTNYIFMGDFVDRGHQSLESFTLLMALKARYPDRITLLRGNHESRQITQVYGFYDECQQKYGNASVWKACCQVFDYLNLAAIIDGKILCVHGGLSPDVRTLDQIRVIARAQEIPHDGPFCDLMWSDPDDVEHWSISPRGAGWLFGSKVTKEFNHINGLDMIARAHQLIQEGFKFMFPDNDLVTVWSAPNYCYRCGNVASVLKVKENEPVTENNFAIFDAVADQDRGAVARVAPSQYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI14</accession>
    <name>I4YI14_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956277.1">
        <property type="nucleotide sequence ID" value="XM_006956215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI14"/>
    <dbReference type="GeneID" id="18473270"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59287"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152504_0_0_1"/>
    <dbReference type="InParanoid" id="I4YI14"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="241" mass="27098" checksum="65DCC22F07980D46" modified="2012-09-05" version="1">MNKPARDRTGDQPRPKRQRRKHDEIERFYHCGFEGCPKSYGTLNHLNAHVIFQKHGPKRLPGEFKEIRAYQKNKKKEELKLRKLKEQGTSPNTPYDETLPSLPNSAPPTQTSFGADVHSPGQDFLLSGPPVGLEEAPEYTNDVLGLGIPFSAPPTRTSFFSNNEDTTADFSTAIKNNLSTLTLPDNISEALTMMENQPHSTKSSPIDQLECSPLLNDIINQTPLNTPFEQFETFNLFDSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI64</accession>
    <name>I4YI64_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">TMP-TENI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WALSEDRAFT_35249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956324.1">
        <property type="nucleotide sequence ID" value="XM_006956262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YI64"/>
    <dbReference type="FunCoup" id="I4YI64">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YI64"/>
    <dbReference type="GeneID" id="18471907"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_35249"/>
    <dbReference type="eggNOG" id="ENOG502QS2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="InParanoid" id="I4YI64"/>
    <dbReference type="OMA" id="GQTDMPI"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EIM23656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="524" mass="55850" checksum="2B8F7CEA0CDA040F" modified="2012-09-05" version="1">MKTEIDYSVYLVTARGLLPEGKDYLESLEESLQGGVTVVQLREKTTDTGEFIQVAQSTKDICDKYNVPLLINDRIDVALAIDCAGVHVGQSDAPLSIARKLLGDEKVIGVSAGNIEQAINAQNGGADYIGIGAVYGTQTKDVTNKIMGTPGARSILAALDPQSPIKTVVIGGIKSENLLRVLNGVHEKDTKRYLDGVAVVSEIVSSKNPREAASNLSHLIKSFRESEKIKYHSASYDVDSIVQEAWRIINAIPEQHPLIQQMANIVTANDQANATLALGASPVMAAVVGDQKDLNPHIGALLINMGTVSEEQKQAMLVGGRYSNLNKKPLIFDPVALGATSFRKQTGQELLNHWAPTVIKGNAAEIGALSGLTEVATKGVDSVGPGFKNPVTVVKSLANRERCIVVMTGKDDYISDGERTVKISNGHSLLGQITGSGCVTGTAIATCCAVSSMTTEDMNEDGKLSRGDHFMAAIAGVLALEIAAEIASKRDDVRGPNTFRSAWIDEMSKLNEINLKKLSCVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YI70</accession>
    <name>I4YI70_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_59315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="I4YI70"/>
    <dbReference type="OMA" id="SDGMGHI"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="430"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM23662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="540" mass="58022" checksum="C73DDE755AADDCA0" modified="2012-09-05" version="1">MPKRLQAPAQQPQATPNPFGAFSTPSQPPPDSSKNNAFSGFSFANPTTASSAFSTKPTATSSFASFGAQKPQEQPKEQPEQNVEKSSSDENAQVYYYASLKGLNKSLIEALRLATDNNPFIDLSTALSSITDEYKKHISSINDKKSQSEKPKEKPLEKSTQSAAKPAPSPAPSTAPTFSMPTVGNFSLKPSASASPSEGQSSGFGFKPTASTEKSNSPFSFPAPSFGSFKPNEKKDDKEEDNKSDKKQSPKPQATNKFASFGQETEKGEPPMEIPPAPKPASAVPKAPAVPSLFNPSNAFEKPATPGSSSTPQTNPFSTGQTLGFGAALGEKKSPLQTSPGFSFGQVGSNSESSPSKPALSFSFGSGSSSMPSFPKPAEMDNAPATPPKFTFGGSQNKTNDGEMNKNNESESSNNISADEGNNSTRQQGAGEEDEDDLYEVKARLYKFEENAWKPSGTGPFKIKQNRKNNVKRILHRDASTTRPILNFRVHSEMKPEVDNKQFMLTGVEEDGSLRLFRLLVKTPELATQTRDALLKELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIA8</accession>
    <name>I4YIA8_WALMC</name>
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        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006956304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIA8"/>
    <dbReference type="FunCoup" id="I4YIA8">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YIA8"/>
    <dbReference type="GeneID" id="18473301"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59348"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992001_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIA8"/>
    <dbReference type="OMA" id="DHFAQKA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33086" checksum="D9BD263C81EC5990" modified="2012-09-05" version="1">MSNGDDLNDDLDYNFDNIESDNDGSFVDEEFMAPNDSEETLEVATGKKRERDDAEPQQQTQQKKKKSKKTKQWFSQVPDIAKSSESSQYDFLVDQLKSAYSKLSDIELEEKLIPESAIEATTSYSQSRSKDTIVDFISSHFGSLKDSLSKQNKQNGSPRLLVICPSAIRCTDIVRSLKQLNPSKDVPIAKLFAKHIKLHEQKEFLQSNQTVIAVATPNRAKSLIEDGAFSTKYLGLILLDTSYVDDKQRTLFDVPEIKQQLFDFLGLKSIYERFKGDKGGQGEKGRKTALCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>I4YID0</accession>
    <name>I4YID0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_53435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956387.1">
        <property type="nucleotide sequence ID" value="XM_006956325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YID0"/>
    <dbReference type="FunCoup" id="I4YID0">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YID0"/>
    <dbReference type="GeneID" id="18472613"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_53435"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="I4YID0"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="144"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM23722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="988" mass="111105" checksum="F2A94E57648EBF7B" modified="2012-09-05" version="1">MDDNLYDEFGNYLGDDLDSDEDIQEEEQQPPAAQTSYAPLEGYEDDDDNENLDVSNEQRISTLMQVDEAPQNQVVLHEDKRYYPSAEETYGPDVETRVEEEDAQHISEPIVQPIKERKFQIEEKDLLETRFDRNFLVDMMHYPEMVRNVVVVGHLHHGKTSLMDLLTFQTHKLTWDSDKKERYTDLHELERSREISIKSTPMSFVLQSTIGKSILVNAIDTPGHTNFVDEVANATRLADGAIVVVDVVEGVMAGTELALKHVLKEGLRPVLVLNKMERLFLELRLPPSEAYFKVKHTIEEVNSVISTIAPHESSRLSPELGNVAFASTDMHWCFTLQSFAQMYADTFGSFDINAFAARLWGNIFFDVERRKFVRKPPQGSPVRSFVHFVLEPLYKIYTQVIGEDVNDLAQTLAGLGISLKPSAYKMDTRPLLKLCLEQFFGPSTGLVDMLIEHIPSAKDGNATKVDRYYTGPLDSPLATSMLTCDSTAPSVIHVTKLYTTVDAEGFYAFGRVMAGRARIGDEVKVLGEGFSADDEEDMAMATIQNVWVSEARYKFECPEIPAGSWVLLGGVDESIVKTATIVSNDVKEDLYIFKPINHISESILKVAVEPLNPPELPRLLDGLRKVNKSYPLLTTKVEESGEHIILGTGELYLDSVLHDLRTLFSEIEIKVSDPVVKFCETVVETSAIRCYADTPNKKNKITIIAEPLEKGISEDIENRRVGMWMTNKERGKYFEEKYGWDTLASRSIWTFGPEDNGPNVLIDDTLPSEVDKKMLGNVKESIKQGFQWATREGPLADEPLRGVKFRIMDAQIAQEPIYRGGGQVIPTSRRVCYSSFLMATPRLMEPIYYVEIITTAESVPTVYQILARRRGHVTKDEPKAGSPLYVVKALIPAIDANGFETDLRTQTGGTSFCLQIFDHWAIVPGDPVDSGIQLRLLEPAPAQHLARDFMLKIRRRKGLGDGQNLMAKYLDDEFVMAIVAAGKSDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIG5</accession>
    <name>I4YIG5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_27215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668224">
        <property type="protein sequence ID" value="EIM23757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956421.1">
        <property type="nucleotide sequence ID" value="XM_006956359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIG5"/>
    <dbReference type="STRING" id="671144.I4YIG5"/>
    <dbReference type="GeneID" id="18470980"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27215"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_1_1"/>
    <dbReference type="InParanoid" id="I4YIG5"/>
    <dbReference type="OMA" id="PEDWPGF"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM23757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="457" mass="49878" checksum="1B5EBEF359C8D664" modified="2012-09-05" version="1">MGHPSDNIITDAIVIGSGFAGAILARKLAKQGRSVIVIESRERLGGRTNTIRLGDHDIDAGCSFIHGYSDSHPLATLSKELAVDVQIAGPKESTDVGSVIIGKRGPLDTGLQKQIQDALGKAVDTAKASNENRPLADVIDASLNETLQGETLAIAKEYVGSLDAPLGLPVNEITDVSRFGWEKGLDGVDAVVTRGYSHLMSRIWEDALATDKVRIYYDHRVVSLSTKDKVKSIISTHRGQFEAKVVVCTVPLATLQNPKTAIEFHPELSKEKQEAIKSTPVGLLEKLIYTYDDYWWRSSYKTGGFAILPTKKSFTSAKEILESHVLNVQTFPNHPSLLIFLPAGAIRLLKCYSRQEVEEAGAEVLAERLGGVKARKAYSTSWLKEQDTNGATSTYASPEHLKALQQATDDDRLAFAGEHTEIDNHGSVNGAVLSGLREAERVERYLQKRASEPWTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4YIT5</accession>
    <name>I4YIT5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_66770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955721.1">
        <property type="nucleotide sequence ID" value="XM_006955659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YIT5"/>
    <dbReference type="STRING" id="671144.I4YIT5"/>
    <dbReference type="GeneID" id="18475146"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66770"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018885_0_0_1"/>
    <dbReference type="InParanoid" id="I4YIT5"/>
    <dbReference type="OMA" id="HEILFTS"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="450"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM23877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="84785" checksum="3EC1F55B52E3586A" modified="2012-09-05" version="1">MDSNFLNSALSQPLHEKSSPFSNNTMHTVNEQKINDASSEITESEQSIIDPEVNNISRTQSQNSQYIYSQSQKPIVQSATSEIPDSNEQFHINFPTPPSYRQYHNMPVTNDHQSDPGTPPISPPITNTNNGFIMQHSNGSRVKSTYDNKPVFQHRQSDMNDQQDYSYQSRVTIPDVIDEDDAVYKSAQIQRRSDLANWAPSRATPAQQSSNIANLPDWRIIEADRKAQTSMPTSLVQADLDYSMRHLLSEKVFEELIRDPLGRHRFREYLEQAGSSSIYKLDYWTDVDVFERIIGQLRAGSQALHDLYIAPSSTTKVDMPPNQSEVVFHRLRYLNELDSGLFSSQANLLHSLYEVEFQNFIRHKLIERSKVRLGKENLSDLEKNGLGDSFVLTNPRLRDHPIVMSSLGFTKVTGFDRTTIIGRNCRFLQGPGTAPAAVQRIRDALNNAEPITELLLNYRRDGTPFFCLVNIIPLRDTKGQVAYFIGGQVNVTGILSSRKNLSFLVGGSAPFISTEAVSSTAVAFSPTMQRYNNHEKQPEKIDRVGAGSVAAGSFDDRSIQDSFHGARAFDHFQPEPEKSGNIFSRIFNSSQARKEKKALDKGAQRLPGAENMLGKEAQPIEKQMEFFNHTYNKLMIVKREKREIVFVTKELLGYLGLPTDTIRQCTDSALNHQDLIQLLTCGSEHRLESKRIKTALKQAFKEGVPLSVTCGIKCRSKFSLRSSSNTDIRFGVLHATPLEDRDGGVYAYSVVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJ33</accession>
    <name>I4YJ33_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_59037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM23975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006955748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJ33"/>
    <dbReference type="STRING" id="671144.I4YJ33"/>
    <dbReference type="GeneID" id="18473139"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59037"/>
    <dbReference type="HOGENOM" id="CLU_067183_0_0_1"/>
    <dbReference type="InParanoid" id="I4YJ33"/>
    <dbReference type="OMA" id="GRIYHND"/>
    <dbReference type="OrthoDB" id="3361381at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM23975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="283" mass="30700" checksum="D85570DD3DDB66FD" modified="2012-09-05" version="1">MNWLSKRLGRRSSTNVPPSPSINYELDDTYKPSTKRRSTLNGIVSHNSFSTLKRPDSLSGADEDASLKPLNSTKSLTFTTNSSSQSVDTNNSDDIESKTFISKASTKPTTVLSLDAHDGVAHIAQAPSPSLSQQNMPSTSYNHYNHPPMYTRPQIHNNPRPLSPPNDDASIMTLASSNAGRLQQADNSIRKSSIHSSSKLDDDEFSTRALAPNSRRASYDSTTTQSLRSYNIGTSPLNPIRSPDLIYPGSNNTYKKSSTTVATTAASFITASERQSLDSVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJE7</accession>
    <name>I4YJE7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_66948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955915.1">
        <property type="nucleotide sequence ID" value="XM_006955853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YJE7"/>
    <dbReference type="FunCoup" id="I4YJE7">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJE7"/>
    <dbReference type="GeneID" id="18475186"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66948"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
    <dbReference type="InParanoid" id="I4YJE7"/>
    <dbReference type="OMA" id="AWPCSNL"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="584" mass="65712" checksum="33C58C8B98421E85" modified="2012-09-05" version="1">MSYKHLLTSQPSDARNPLRVICHADLDAAYAQFERKRLNLPLDAPIVVQQWSGLIAISYPARAYGITRHENIFEAKKKCPNLVPVHVATYKEGVEEPGYWNEKPSPDSHKVSLEPYRREGAKVLKCMQEIFVGCEIEKASIDEQYIDLTELVRNKILERYPFLKQLPPDKTLDDVLPEPPIISFADVGNVIPTSSEKGSDGEIIADEEMQTTWEDVAIQVGAQLVAEARKIMFEKIGYTCSAGISHNKILAKLCSAYKKPDDQTVLRRDAVDSFLGPMSFQKIRSLGGKFGEALAAHYDAATVSDLWKVPLGEMQRQFGEESIWIYNTIRGINSDEVKERVITKSMLASKSLRPPINTVGEVRHWLKILSSELSQRLKEVRGEEGKKTMWPKSIVLSMNQVYQSSRSHQGAFPYNNSFGPELIQKHAEKLLKEFVRCDTKEMPDEHKLGYDVNKLALSFSGLATVEAGQRGIEGFLGQMTKNGNDGKLKRQHSTDSTKADKTEKAVKKKKSKGTPQTGLTAFLTKPRQGQEKPKAKKETIEIDSSEEDVAGDVYNCKECGKKLNVAEKVEHLDWHYAMELQDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YJM7</accession>
    <name>I4YJM7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WALSEDRAFT_67017</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006955990.1">
        <property type="nucleotide sequence ID" value="XM_006955928.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YJM7">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YJM7"/>
    <dbReference type="GeneID" id="18475199"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67017"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="InParanoid" id="I4YJM7"/>
    <dbReference type="OMA" id="LWANECT"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000007">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="219"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="595"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="937"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1439"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EIM24169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="2640" mass="300125" checksum="80C429CA3AB5AF57" modified="2012-09-05" version="1">MSNKQLNGQPQSGTAQVELLGKSLNINQRMGVFVTSNPGYAGRSNLPDNLKKLFRSQAMTQPDRESIAQVMLFSQGFRSAETLASKIVPFFVLCAEQLSPQPHYDFGLRALKAVLISAGNLKRDRILTSGTSSNQDDNDQVEQEILIQSVTETIVPKLIAEDVPLLTNLLSDVFPGIEYVPVDLTALKEKISQVCHERKLVQGDLWLTKVLQLYQIQRIQHGLMMVGPAGTGKTQAWQTLLQALERYDGIESVSYVIDPKAMSKEALYGTLDQTTREWNDGLFTHILRKIVDNVRGESSKRHWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLNLPSNVRIMFEVEHLKYATPATVSRCGMIWFSGEAVTQEMYCKNYLDTLSNVPLDGDEETGIDLAVRRGEVISSNNQQVSPSLELQRKVVEILKPSFQPGMILENALQHAMSYQHIMDFTFMRALTTLFSLINKSIRNIIEHNVQHSDFPLSLERIEQYINKRFLVAIVWAFTGDSKLDIRLEMGDYLRGLTTIELPMIGQGMSLIDYDVNVANSEWFNWTEKVPTIELETHAVTAADVVVPTVDTIRHEEVLYSWLSEHKPLMLCGPPGSGKTMTLFSALRKLPDMEIVGLNFSSATTPELILKTFEQYCELRKTPNGNVLAPSQIGRWLVLFCDEINLPALDKYGTQKVISFLRQLVESNGYWRTSDMTWVQLERIQFVGACNPPTDPGRVPLTQRFLRHAPLVMVDYPGEISLNQIYGTFNRALLKTVPSLRGYAEALTGAMVSLYLESQRRFTADIQAHYIYSPRELTRWARGIFDAIKPLDTLTVEGLVRIWAHEALRLFQDRLVLADERKWTDDRIDAIALKYFHNIDSKHALARPILFSNWLSKNYVSVDRDELREFVKSRLRIFEEEELDVQLVLFDDVLDNVLRIDRVFRQVQGHALLIGVSGSGKTTLSRFVAWMNGLSIFQIKVSNKYTGDDFDEDLRTVLRRAGTKGEKICFIMDESNVLDSGFLERMNTLLANAEVPGLFEGDEHSALMTACKEGAAKDGMMLDSHEELYRWFTSQVSRNLHVLFTMNPPENGLASRAATSPALFNRCVVTWMGDWAPTSLSTVASELTDPLDVDMRDYIPPTPFPSAHPTLQAPITYRGAVVNAFVYIHLSLHEISKRLSKRQGRYNYITPRHYLDFIDQYVKLFNEKRNELEEQQRHLNVGLDKLRDTVIQVDELQKSLAVKDTQLKAKVAEGDDKLAKMLEEQKQAESNKATSIEIQAKLQEQNEHIAQRKEVVMTDLADAEPAVKSAQESVSNIKKQHLTEVRSMGNPPEAVKLAMESVCTVLGHKLDGWKTVQGIIRRDDFISSIVNFDTTKQMSKNLSDRIKNDFMSRPKYNFEDINRASKACGPLVRWVIAQVHFAEILDRVGPLRNEVKYLEDKSLHTQKQASAIIDMIKELEESIEKYKGEYAGLISEQQAIKSEIERVQKKVERSKTLLNSLSSEQERWETSSKTFESQMSTIVGDVLLSAAFLAYAGFFDQQYREGMWNGWSTYLSDAGIKYKQELSFADYLSTADDRLSWQSKSLPADTLCTENAIMMKRFNRFPLIIDPSGQASNFLINEYKGSNRKLNVTSFSDNSFLKQLESAMRFGNPILVQDVEFLDPIINPILNKEIRRTGGRILIRIGNQDIDYSPTFNMFLMTRDPSVEFSPDICSRVTFVNFTMTRSSLQSQSLDQVLKSERPDVDAKRTNLLKLQGEFRLRLHFLEKALLQALNQSTGNILDDDKVIETLETLKKEAADVTLQVKDTDTTMAEVDQVTSDYQPLASACSSVFFVMDQLNLINHFYQFSLKFFLDIFDYIIRQNPNLNEVTDYKDRLNILTNDLFLVTFQRTSRSLLHVDHVMLAVLLAQVKLRTLAGAYDEDEFDFFIGGGDSLIGKTKPENDLQELLNDEQASKINLLSVRVPSFSEIKNVIRTDSDKWRSFLLANQPELDVPLGHNDGLPASIREIRELLIIKCLRPDRLVQATSHFVNAVFNTDLTDLTTYNFQNLVQKEVGPQTPVALCSVPGYDASYRVDNLVSGLGIRCNSVAMGSPEGFRQAEQAITQSARSGQWVLLKNVHLAPGWLTQVEKKLQTLNPTPNFRLFLTMETNPLVPINILRQSRIIMNEPPPGIKANILETLRNISPQSLQNGPVEKMRLYFLLSWFHAVIQERLRFCPLGWSKLYEFNDSDQASALKMIDTWTNRVAKGRSNVDPSTFPWEAIRTLLKESIYGGKVDRDFDQKLLNTFVDKLFTPDAYEINFQLVSEVDDQPGLNIPEGTKLEQFIAWAEKLPEREPTTWLNLPITAEKVIAVAHGSDLLGKLRKMKSLSDDDETVSVNTSEESNQQPAWMRTLMSNCQEWLELLPKDIGQFDTDASRAQDPIFRFFKRESEIGRRLYNTIRCDLDDLISVCKGEMKQTNHLRKLMNDLTKGTVPSHWKIYRVPNSWTITQWVPDFSLRLQQIQRLVGEQNTLSQSTIWFGGLFFPGSYLTATRQESAHRTRISLEELQLELYIDNSEETGFAIDGLYLEGADYEGGKINATNLDPIKLNTCKLKWTERRNHEISNAVSLPVYLNLKDREVVLFSANLSAVDGLSEAEVTQRSICLSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YK15</accession>
    <name>I4YK15_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_56082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668223">
        <property type="protein sequence ID" value="EIM24307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956119.1">
        <property type="nucleotide sequence ID" value="XM_006956057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YK15"/>
    <dbReference type="STRING" id="671144.I4YK15"/>
    <dbReference type="GeneID" id="18472769"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_56082"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1670731_0_0_1"/>
    <dbReference type="InParanoid" id="I4YK15"/>
    <dbReference type="OMA" id="KEMENCA"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM24307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="170" mass="19433" checksum="FEBDE15421FF8335" modified="2012-09-05" version="1">MSDIQEASKSSKKDFKREKGTTHMPIARVQKIIKADKEMENCGREATFLIAVATEYFIKYLTDAGYIEARLDKRNTIQYKDLAHAVDKSEELEFLKEIIPSKLTMQKALELQHNKRNQVDGPGNTNQDDAIPFEPPHKNKKKTHAQAEQMATEPLQPLEPPQSDPQPMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y538</accession>
    <name>I4Y538_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668261">
        <property type="protein sequence ID" value="EIM19080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960864.1">
        <property type="nucleotide sequence ID" value="XM_006960802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y538"/>
    <dbReference type="STRING" id="671144.I4Y538"/>
    <dbReference type="GeneID" id="18474657"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61647"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020413_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y538"/>
    <dbReference type="OMA" id="QVGMTNT"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="586" mass="62736" checksum="5315CBD8623C510B" modified="2012-09-05" version="1">MSSNTPDPITLSLFSNRFISCAEAMSKSLEQTSISTNIKERLDFSCAVFSPIGDLIANFPNIPVHLGAMSYAIKYQLNLHKNDLRPGDVLLTNSPIAGGSHLPDITIITPCFDKATNEIIFFTASRGHHSDIGGILPGSMPPNSTSLEEEGAEIVSFKLVQNGRFDSETLYDLLVTQPSKVEGSSGCRNFKDVQSDLKAQVSANHKGIQLLHLLCKEFGLSMVQEYMYHIRNNAEYAVRNLLKTVARSTGRTTLSATDYLDDGSPISLTVKIDEIHGSAVFDFNGTGPELRGNLNAPISVVHSAVIYCARSMLGVDIPLNSGCLAPIDIIIPEGSLLSPSPEAAVCGGNVMTSQRVVDVVLKAFEACAASQGCCNNVTFGAGGKDPITGEIKPGWGYYETVAGGSGATKDQDGVSGTHVHMTNTRITDPEILERRYPILLRRFEFRRGSGGVGKHRGGDGVIREYELMQPLQLSILSERRVTRPYGLHGGGDAQPGLNLWLKQPKKKAISSGSNTDKPRIINLGGKASAKMSKGDVFILLTPGGGGYGHPSEATDDAPSRASLGLTEDFTPRGSVFERHSLAASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y585</accession>
    <name>I4Y585_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic-AMP phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668258">
        <property type="protein sequence ID" value="EIM19127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960823.1">
        <property type="nucleotide sequence ID" value="XM_006960761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y585"/>
    <dbReference type="FunCoup" id="I4Y585">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y585"/>
    <dbReference type="GeneID" id="18471844"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34258"/>
    <dbReference type="eggNOG" id="ENOG502RFKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016658_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y585"/>
    <dbReference type="OMA" id="NTHDAYA"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45062" checksum="22208810BABDBED0" modified="2012-09-05" version="1">MLDDLRNSLPDESCSASSAYPPTTTKADTRQDVDGYRLASRIFSSITSYLITHPHLDHLAGLIINSSQKFGSYKSLIGFEKTLKGVELAFGGLLWPALASWSKAGGLVERLQFTQVEPFAKFDVLTPAVTFKCTPFPISHGTIGLVPDARTHAYLQVEKDPNEVYDSIAYFIEFEHQEKNRSFLFWGDVEPDAISTLPRNKPVWIEAAKRFVLGELRWIWIECSYMNNRPNNLLFGHFKPDLLIDELETLAIIVEKFKQLPVEELKNVNATEFSIDEYINESKMKDETQSVSQDSVEDDENGSVPLSQANQASQAVRKALFGGLNHALRIGYNKGFGFFQHTTEKPLDGLVIAITHVKEDPMLGCDVVSETIMRELHSNSSTEDLGVKFYRPKQGERIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5D6</accession>
    <name>I4Y5D6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668255">
        <property type="protein sequence ID" value="EIM19178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960750.1">
        <property type="nucleotide sequence ID" value="XM_006960688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5D6"/>
    <dbReference type="GeneID" id="18475126"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66574"/>
    <dbReference type="HOGENOM" id="CLU_1670733_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5D6"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="158" mass="17783" checksum="323FFE5D10C1F08B" modified="2012-09-05" version="1">MVNVGNNTFVASYIALYIFLLQLVGFVSAAKHEGKENCQGSDICYTYEHDSSDYIISDVTEPFKLKIDFNGIFTELDEEKYSKLVKQSHLDGASDEDNIQYSNLSKIEERGLNKRLGLDACCNGLVDDAPRRSGDISDDVSTSEKRQMPTYEQYLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5H2</accession>
    <name>I4Y5H2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WALSEDRAFT_34180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668254">
        <property type="protein sequence ID" value="EIM19214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960711.1">
        <property type="nucleotide sequence ID" value="XM_006960649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5H2"/>
    <dbReference type="STRING" id="671144.I4Y5H2"/>
    <dbReference type="GeneID" id="18471833"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34180"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="I4Y5H2"/>
    <dbReference type="OMA" id="IGMAAPY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="324"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="643"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="972"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EIM19214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134098" checksum="E57CFA16B4766F0B" modified="2012-09-05" version="1">MFGNLVNEMNNFYNFVPTYRDDPTNQANIDEFNDRKSTFKSGVNYNCLMLLVIAICMFVATYGYFYIFTYTSERISRRLRLLYLRSVLRQDIAFFDKIGAGEIATRIETDMNLIQSGISEKVALACMFLSSFIVAFIIAFSVQARIAGVLFIVVPCIAIAMVVIITFITKFEENALKSIGDSGNLAEESISTIRTAKAFGLQLNLSLLYDNFLYKARKEGFKNAYMTSIGFASFDFMAYSTYSLAFVWGVTLLLKGQTDIGSIIKVVEAIIVGAFGLGLVAPQLQIIAKGQAAAAKIYETIERIPPIDSASEDGLKPSSIDGNITFKDVNFAYPARPEVQVMKNFSTKFSQGKFTALVGASGSGKSTSIGLIERFYDPNSGLIELDGTNIRDLNVKWLRSKIGLVGQEPVLFNDTVRANVEHGLIGTEMEHWPDDQKLELVIKACRTANADSFIQDLPERYDNTVGERGMLLSGGQKQRVAIARAIVSDPPILLLDEATAALDSASESIVQKALDQASMNRTTVAIAHRLSTIKNADQIIVMDHGEILEVGDHTSLTAKSDGAYSQLVSAQQLSNHMRVDNIDADTDDQSIHDMASVKDSVRSPGSEIMNVMEDVDDSKKYSWGYLLKSLIKLNRSSWPLYMFGSIAAMISAAGFPCFGIVFGLIMQDLSLKSVDDADYHSYMRRTTDRDSLWFFIIALGIGIALVVQNYCMQKSGEKLTFNLRHESFKKLLRSDVEYFDKKENNTGVLCSGLADNARKVQGLAGLSSGSVMQCLWTVIIGVAVALGYSWKLGLVGTACIPLTFAAGLTELKVVTLKDKYNRKAYEESANMACEASGAIRTVAALTREDSVLAYYDNLLLKPYTTSIKSGVWRSAAYALGQALSFGCIALVFYVGALWLMDLSMDLQSFYVTLESVIFSTILASRVFTYVPDISSARGGATRILKLLERVDKIEVEHDNKDGKHLETIEGHITFENVHFRYPTRSDVPVLRSLDLEIKPGSYVALVGPSGCGKSTTIQLIERFYDAVCGSVKLDGHEVRDLNLNNLRSHMALVSQEPTLYGGTIKYNIIMGAVKPHEEISQQELEDACADANILDFIKGLPDGFETQVGGKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDQTSEAVVQAALDKVASGRTTIAIAHRLSTIQKADRIYVFKDGRVSQAGTHQELIEEKGGLYAELVALQSLSKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5M5</accession>
    <name>I4Y5M5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_34141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960661.1">
        <property type="nucleotide sequence ID" value="XM_006960599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5M5"/>
    <dbReference type="GeneID" id="18471821"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34141"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014851_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y5M5"/>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="676" mass="76381" checksum="7F5585E1ADBE4493" modified="2012-09-05" version="1">MRESNFSNPQQNRASCVVSTSFFDRKALDTRDPVALINSLTNLQYLTSVSQKVRDIVALDGGIERLVRIMKWAMSILLVPGASASPTPFLLPADRGSQPLQGVYDRQILYIWTLAFQCCVNIGVRGSEELRTKVVQAGVLDVAGAILGTWKASMDRYRLKKIKEYHLHTISLRAWLNDQHNRKVSKSTQPTNRSVTPESSLLADDEQINGLNEVPQVSPMPPAVPNSTPNFTEQNNDQVEPSTSAQTEASVSRSSSVVQSEDDAEEQQPETSSYVRARSGTVVPSSQSQQLQSNPQLTPANTPQAPVIQQQTPQQPQLTQPVQSPNSSPITRRPIEHIEYFRPEENTIYREEDVLLALQLLAYISKYPHIREGFQAPSRAWQVGRPSFDPEENPMDRLAYRDYYKRNLFYVVESFTYEGHIDDPTSIYLPSEIRYWAGVTMRNACRKHESFNGIRQCANVACGKWESSPKEFAKCRICRKAKYCSKECQSRAWRVGHRFWCQTRSDMANESENFVPTYLARDDNQQTPIIRPEPQAPAQQIPQPGSPLATINQINRDFDNWTNVNQEPDTTANIFEDEFTRRFTGIEQTPNPQNHFQLPPLRFNDDVGVGNATLATAEQTPSPPQQPVSPGLTASISEGAEERERRHQTQDYLPRTRSALSEVLTVSSEDHEMQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5Q5</accession>
    <name>I4Y5Q5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_34160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668253">
        <property type="protein sequence ID" value="EIM19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960689.1">
        <property type="nucleotide sequence ID" value="XM_006960627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5Q5"/>
    <dbReference type="GeneID" id="18471827"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_34160"/>
    <dbReference type="HOGENOM" id="CLU_478338_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5Q5"/>
    <dbReference type="OMA" id="TWIVAEI"/>
    <dbReference type="OrthoDB" id="3364606at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="570" mass="64564" checksum="F9A608DC771A6F07" modified="2012-09-05" version="1">MSDISGSTDWLDVAHQLTDEDDLSLSFPDPLDKSHFENALEHQSSVSQATDEWPSDIESTASTTNQSSHDENLMAIPHHMSDSLQNTNADNSLSSSARTIKSGTSTHSPFKLVVFNMGDFPNVSQRIKSSFIKSVYDNISGFVIEKDHTKYIINASNPDICFPVNDEEWRKPGNFFQLYFEDVSIDSDKLQDSIFKILLENLPTIVVIPTNALNNETIMVYANALKLKSKLKIIKFDLDETEGDLDEETLTLNELTNNTASHKLRSLFGDLEGTETDENFAAYDTKEHFQPEKVEEKCNRASLQAELTDVCFRYSLWSFKYTCSVFGLLLVSMLALNVFKLATEGSYDTYWLSKLNNTSYTQPRSSSSADKAPSCHITPSLSFKPLPMGNYRLKTIDQAKPTTDLSIFNQVLDVVAHIPKRNALNSQTNQNELTLREQLNIDTVLSKVEEICGQAYVISLYYLDEHLRQIAALVETLIGISYTAAEIGYENAKFVTKHTIDYTASVYNDVIRHAPPVIRKHVRHASKQINRLSQQAEYSINDGISYLNKKSYNHLKRARDNYRRVFNKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y5X0</accession>
    <name>I4Y5X0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_61534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668252">
        <property type="protein sequence ID" value="EIM19362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960638.1">
        <property type="nucleotide sequence ID" value="XM_006960576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y5X0"/>
    <dbReference type="GeneID" id="18474589"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61534"/>
    <dbReference type="eggNOG" id="KOG4744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367179_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y5X0"/>
    <dbReference type="OMA" id="NDNTEHT"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="22859" checksum="4AC4201748AB29AF" modified="2012-09-05" version="1">MFSRVRIGTQISRSVRRYASASSGRVQKPLPVFNKESDKVWMAASALVTIGGAIYLTSPGSEEHGHGHAVEHASEKAEETKEEVKEESSEAKEATEEKAEDVKEAAEEKVDDASEKASEKKEEVTEKAEEKVDDAKESVKETSEGAAEKAEEKTSEVAQKAEDKSEDVKENVKEGAETAKENVKEGAEEAKEKVEEKKEEVKEKTESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y684</accession>
    <name>I4Y684_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF926-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_66340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668250">
        <property type="protein sequence ID" value="EIM19476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960508.1">
        <property type="nucleotide sequence ID" value="XM_006960446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y684"/>
    <dbReference type="STRING" id="671144.I4Y684"/>
    <dbReference type="GeneID" id="18475108"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66340"/>
    <dbReference type="eggNOG" id="KOG2812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032439_4_0_1"/>
    <dbReference type="InParanoid" id="I4Y684"/>
    <dbReference type="OMA" id="MSEREYG"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="4">
        <location>
            <begin position="172"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM19476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="281" mass="32969" checksum="8BA0CD29139D5128" modified="2012-09-05" version="1">MSNDQINKADIVSESSGHSIDKTADEYDRRRSRREEDYNERRNRNRRGSPRYGNTRALVPPKFEGEPGSTRWIESRAEYRKNVKFSIWPPSPPGPTFASLSPPSRDTQKRRHKSGYERRHKHRRKHDDEQRRHERENEKTSDTALSTNEYANYDEDIGPAPLPEDLIKLRERDYGSDMLRGEGSAMAQYVQEGERIPRRGEIGLESNDIDKFEQAGYVMSGNRHKKMNEVRVRKENQVYSAEEKRKMLKQSAEERLKKENEIVASFRELVSEKLSDSKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y697</accession>
    <name>I4Y697_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_61412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960414.1">
        <property type="nucleotide sequence ID" value="XM_006960352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y697"/>
    <dbReference type="GeneID" id="18474519"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61412"/>
    <dbReference type="HOGENOM" id="CLU_1300544_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y697"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697431" evidence="2">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="212" mass="23650" checksum="691C56E003994979" modified="2012-09-05" version="1">MDIMPLLLALFQLASILIASGVSLSVQRKPTNEWGVRTVRLLLFVIHFQILYQSYLYDLAKKYVGSKTTAPRTNDIGDCTVESFLKGKLSNFLATLGLSSICDNTIFYDVTKNSGVKIHILNEGTCSNEATNETIFDGVQDTLSWLIDAKCQRCCATLAHDGGWKATIKMSGDDSRMNPSIINCNKSAKYKCKWNENSPRVSCVAWNEYNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6D5</accession>
    <name>I4Y6D5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_52750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668249">
        <property type="protein sequence ID" value="EIM19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960451.1">
        <property type="nucleotide sequence ID" value="XM_006960389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6D5"/>
    <dbReference type="GeneID" id="18472593"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_52750"/>
    <dbReference type="HOGENOM" id="CLU_411725_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6D5"/>
    <dbReference type="OMA" id="YHRETRA"/>
    <dbReference type="OrthoDB" id="3362828at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="667" mass="72539" checksum="5FC079F62EC55781" modified="2012-09-05" version="1">MAPYVTQEADRRRESSQMERELLEIVGTAEESENEMRKVITKLQRKLQDAVQGKESDEATLKGLQEALRDAEARGLALAQARKEAEIAAANETRRIEGYRYRDGERHRELAHAGDMIRQLQIDLDDAEEEVLFLRQRAHKADIVEAERRGRNQEREKRRKEKDRERERKALAAANAAVVSNPNGARHHIPQHHRSPSTQAPSTHTATSPRMENGHSRANSLYEPRRRPSHRHSYTQHQHHHSQPQQYQQPPAMMNDHLQAGPYGPAGGHSPHHSSPGGPDQMSIYPPSTVPDPRLGPYRAPRPERAEGLQNYYEPPGWPRRPPTMTDAPSVQPPPSIQANGSPIVESSQPPLGVVNQPSQPENLAALGQSDGDYYRRPSYSATQQGGNVPEPIHPYETGGGRPAGQPYNPVIVEPGQETGIEIQNEMGPRSALGLNGGGISRVHTPIPPGGLGGVSRGATPVPEINLQPPSLKGTPMPRLDPAGVPLPESVYGGSNYTHQTGHHSHHHSLPHSHPNSHPHSHHHRNPSLQSFGDPAGIPLPHSRPGSSMYQHPHLGSTGTGLGIQRAPSMMHTPRHASNIPLPESVMGSPRMSEGTAYRGMPPIQPVHPISEAAARSPTMSALPFPPSPSVRSAQAPLGPDIHPLSQAAGNGRQSVPPGAPPGAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6H6</accession>
    <name>I4Y6H6_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_30270</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960366.1">
        <property type="nucleotide sequence ID" value="XM_006960304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6H6"/>
    <dbReference type="FunCoup" id="I4Y6H6">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6H6"/>
    <dbReference type="GeneID" id="18471137"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30270"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="InParanoid" id="I4Y6H6"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="435"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="503"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="706"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="966"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="572"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116721" checksum="6AC307C7DC711127" modified="2012-09-05" version="1">MDSQRKELDDKVKSVHYKLSTERTMLDSAQKMRNAHMGNAMARSLVETQIREAQRNVTFFEDTLRDLVERRKRLLERELPKVPGDGDQPPSQPIERESSKRVGKTQISNFELTKEDCPYTPAKVSLMLHQLDYKLAREQHYKAGIEKMAQLYSAEGDKRSRSETQLKKIESDAKMAILRQALRRYQNLYVAPVSEDSGAVDEPAKVDGLRKPLSGTLKIQIKSARDLNHKLISNQSSRHHRQPALETLILIKVGEDTSPVKTRASRSTGHNQWNESFEVPVDKINEVEIAIHERQAGASDSGVPIGLMWIKVSDLVEELRRKKADAEASALLERMNQQGSVDRPGQQLDSLSSVDGPNDLSPKSQFDPTQSITKASPRLDDDGVEGWFSIQPAGAIALKLNFVKQNVRKRPAENNGLGRQGAVRKRKGQVHEMNGHAFVQKQFITNVIKCAYCEDFVLDGRVYRCDDCRYTCHRSCYEKVVTKCVSKQDSGEKDEDKVKHRIPHRLAPISSLTPNWCCHCGEIINPLSKKARKCSDCPVTCHAECAHLLPDFCGMSMVTANSLLRQMQAIGAAKKQPTQKPQPIPSKTPSIEKIDDAEKTTEEIEKGAQKMDITSPQLPVTQPQVPSRQQQQQPQAKPQRVEVPRPYPPPSQQPQAQVPSPTPYSRQHPGQPYRAPPPQFQKQQQVTPKAPQVAPAVQRKVGLDNFNFIAVIGKGNFGKVMLAEEKRSSSLFAIKVLKKEFIIENDEVESTRSEKRVFLSAAKQRHPFLLGLHSCFQTETRIYFVMEYVSGGDLMLHIQRQQFTPRQAKFYASEVLLALEYFHQEGIVYRDLKLDNILLTLDGHVKVADYGLCKENMFFGNTTSTFCGTPEFMAPEILLEQRYGRAVDWWAFGVLIYEMLLGQSPFRGDDEDEIFDAILEDEPLYPIHMPRDSVSLLQRLLTRDPTKRLGAGESDAEEIKSHAYFRDVNFDDVLNKRIPPPFRPSIGSATDISNFDTEFTREQPTLTPVQGQLTESDQAEFAGFSWIAPWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6K3</accession>
    <name>I4Y6K3_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_61405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668248">
        <property type="protein sequence ID" value="EIM19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960393.1">
        <property type="nucleotide sequence ID" value="XM_006960331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6K3"/>
    <dbReference type="FunCoup" id="I4Y6K3">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y6K3"/>
    <dbReference type="GeneID" id="18474514"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61405"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6K3"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="265" mass="29071" checksum="03CD0F568728EF8E" modified="2012-09-05" version="1">MFVSRVNAIRASRKVDINVLVPIKRCIDYAVKVRVSPDGKGVDNTVKHSMNPFDEIAVEEAIRLREKNKSLVDSITAITIGPQKAQDTLRTALAMGADKAIHVQAEHNVEPLQVAKTLKHFIDRDKFELVLMGKQAIDGDENATGQMLAGLLDCGQATFASSLKVADGKATVTREIDGGLETVEGNLPMIVTTDLRLNEPRYASLPNIMKAKKKPIENVKESDLPVDLKNRLETIKVTEPAQRTGGQKVDSVDELVEKLKQNALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6N2</accession>
    <name>I4Y6N2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_70436</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960287.1">
        <property type="nucleotide sequence ID" value="XM_006960225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6N2"/>
    <dbReference type="GeneID" id="18475739"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70436"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374366_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6N2"/>
    <dbReference type="OMA" id="MYQNQFP"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="45"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="335"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="602"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="668"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="390"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM19624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="742" mass="79307" checksum="A780595699501ABF" modified="2012-09-05" version="1">MSNRKSNSSVKILKELFPHWNDDDLNQVLIDVNGVLESAVARISEGHASQFSTVQSKKEKKATPAQPAPSLPSVKSDSQKQRSAPTRGRANSSRGQPATRGSFNPPRGPRGGSARTSNRQATKPKDQSASNSATPAKWSDNKPSTSSDAPTSATTTQSKQSSASKSWAQIAKPPSPKPVPIAQVDPKPAPVPTKAAEESTNEKAKEVSQPPPENIAWDVPAPGPAPTAPPSSAWNKNESAWASNSADTNANAWISKENAWEDKPTVAKSEDDSKQPQPSTQSSAPPGFGAPKPNSRAAQRARQDAAVVMPSAGDNKSFGNAIGVQFGSLSLLDNPAAYEEQQEQPKAAQQAQESITVPQAEPAAPAQPATQQAQQPAAPQQPDISAYTASSQQPQQDVYGQYFQQSQQQPATQQAQPSQTDITQQQPQQQQQPQQQQPITSQGIPPQFQQYNQAITPTPDAYSNVFSNLAAQPNQLSGGAFGQQTQNDYAALYNDQAQRDFALQQANYYGQQQPSSFGRQIGQEDSSKSVPTPSINQATTPSISSQQQTASGYPGITAPMPYYFNPYAAAYGAPNAAAFYGQAAASPYNQFPKYPMYPAGPAQPSAGFQQPAQPKPSNAAQTGNGATAATSSQSPYVQHSTATNVASPSPYQSYDPSTAYDSFLNQTINNAGSPAISHQDKHQSKPQHQNPQQQHPQHPQQQPYNAFGSAYQAPPLFQTPSFSHYQGYGGWQAQQRYGQGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2023-06-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6S1</accession>
    <name>I4Y6S1_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_66167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668247">
        <property type="protein sequence ID" value="EIM19663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960325.1">
        <property type="nucleotide sequence ID" value="XM_006960263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6S1"/>
    <dbReference type="GeneID" id="18475088"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_66167"/>
    <dbReference type="HOGENOM" id="CLU_1504606_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6S1"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="179" mass="20860" checksum="4AA81AF034A8313A" modified="2012-09-05" version="1">MNKRQFNKFENHRSINKPYTQPNYKSQLSSENYKTLLTGHLLPDVSLFDRGSDATYTCRLDLLTNVRQLHTPERFSTISGDAKSSLVRTMHLNLGYQNGTISWIEKEAYYSPHHTSTILSKKLLEEYNLYLFCKPPYRATFHNSHNGKLVYDVPFINGKLLFKLSVNPIYNVLKYIFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y6Y5</accession>
    <name>I4Y6Y5_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_30170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960235.1">
        <property type="nucleotide sequence ID" value="XM_006960173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y6Y5"/>
    <dbReference type="GeneID" id="18471132"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_30170"/>
    <dbReference type="HOGENOM" id="CLU_1058464_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y6Y5"/>
    <dbReference type="OMA" id="YEKHEEH"/>
    <dbReference type="OrthoDB" id="3365922at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="263" mass="30685" checksum="A412F7BDA8AC3113" modified="2012-09-05" version="1">MKLNDLSNPFNNFDITSWSTNLVDKINKTLKRRNREEDQLARPSKLARLDSDNITDNNGVTHDDHLHLTSTKLDDGDDILLNEKIDDNNDAYDDDDAKANDAYWRGEDPADDRDDNVLAKHEFDKGYNDDSESEDDEKVDEEEDELDREVDELDGEGYDEDEYESVQNDKIDPRRLPSYEEEVVGQVDSEDIMNNKEKFENDREQDSEDEPEDDEEDSQHNHPQEFAEHYNDYVYSDEEDEEEEDTRATTRNDAPIELSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y721</accession>
    <name>I4Y721_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_55468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668246">
        <property type="protein sequence ID" value="EIM19763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960271.1">
        <property type="nucleotide sequence ID" value="XM_006960209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y721"/>
    <dbReference type="STRING" id="671144.I4Y721"/>
    <dbReference type="GeneID" id="18472731"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55468"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_1_1"/>
    <dbReference type="InParanoid" id="I4Y721"/>
    <dbReference type="OMA" id="PRCSHNC"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="208" mass="23623" checksum="D12CED82DF1EABE9" modified="2012-09-05" version="1">MVYPAEQREKSEKLDSTTWNLPTEKKLYVHHLNDPSNAPKELLSRLHQLFNFIIEEGRTYPIETPMSVEQFKSYFFAADLFVGLLVDKPLSEIGDNEWDVVLGGCYYVKPNYVGRSGHICNAGFIVNANKRGLKLGSTLGKSYLHYGPKLGYKGSIFNLVYQSNIASSRIWDGLGFTRIGIVPKAGRLIDDKGTEYYDDAIIYYKSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y763</accession>
    <name>I4Y763_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_70326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960139.1">
        <property type="nucleotide sequence ID" value="XM_006960077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y763"/>
    <dbReference type="FunCoup" id="I4Y763">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y763"/>
    <dbReference type="GeneID" id="18475716"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70326"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098333_6_0_1"/>
    <dbReference type="InParanoid" id="I4Y763"/>
    <dbReference type="OMA" id="SQSHEVE"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="109" mass="12604" checksum="90215992FFF46397" modified="2012-09-05" version="1">MQSERSRTDDGSSSQTIERSNSRQQQTHVLKLRGHQPEQRSAVRWEEGTVDNENMNKKKSKICCIYHKPKRFDESSDESDCSDSEHKPCTSKSNKYDNPSHSHSHPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y768</accession>
    <name>I4Y768_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_33806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668245">
        <property type="protein sequence ID" value="EIM19810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960144.1">
        <property type="nucleotide sequence ID" value="XM_006960082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y768"/>
    <dbReference type="STRING" id="671144.I4Y768"/>
    <dbReference type="GeneID" id="18471751"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33806"/>
    <dbReference type="eggNOG" id="ENOG502SGQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167733_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y768"/>
    <dbReference type="OMA" id="MSGYKAN"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM19810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10261" checksum="7549C0C28143A523" modified="2012-09-05" version="1">MSDSPNKNTGIYHSIKGNIVESVGTATGSEEWKKSGQQEHVDGEAEQKAAEIKDKAEGVYDQVAGRVSNIKAAVTGDKSGQVEAAAREESGKAAQKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7E0</accession>
    <name>I4Y7E0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_33699</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960024.1">
        <property type="nucleotide sequence ID" value="XM_006959962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7E0"/>
    <dbReference type="FunCoup" id="I4Y7E0">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y7E0"/>
    <dbReference type="GeneID" id="18471732"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_33699"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y7E0"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="183"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="493" mass="53321" checksum="80BB8D57559773D9" modified="2012-09-05" version="1">MSQEAVADIGLIGLAVMGQNLILNMADKGFQVSAYNRTTSKVDDFLANEAKGKPIVGAHSIEEFCKQLKRPRKIILLVKAGPAVDSFIDQLKPYLEKGDIVIDAGNSHYPDSIRRTQELEKDGLLFVGSGVSGGEEGARWGPSIMPGGNPEAWPHIKEILQKTSAQVNGNEPCCDWVGDQGAGHYVKMVHNGIEYGDMQVLGEAFDILLRGVGLSHDEVAGAFKKWNSGVLDSFLTDITAQILEHKTDGEATVDSILDSAGQKGTGKWTGVNALDLGTPVTLIAEAVFARCVSSLKSERQTAAQKLKGPAKESFSGDKAAFINDLEQALYGAKIISYAQGFLLFREAAKEYGWKLNNAGIAKMWRGGCIIKSVFLGDITKAYERNPELESLLFDDFFVKALENAQAGWRRVVAQATLWGIPVPALSSSLSFLDSYRSADLPSASLIQAQRDFFGAHTFQVKDSAKSDKFVKGQPNHLNWTGRGGRVASSAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7I2</accession>
    <name>I4Y7I2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668244">
        <property type="protein sequence ID" value="EIM19924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006960063.1">
        <property type="nucleotide sequence ID" value="XM_006960001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7I2"/>
    <dbReference type="GeneID" id="18474423"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61258"/>
    <dbReference type="HOGENOM" id="CLU_1220511_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7I2"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM19924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="227" mass="25530" checksum="7587170E1A949640" modified="2012-09-05" version="1">MYKCEICHGRFSRPENMMRHKRNSHRSGDLHPYLCSCGRSYTRSDILLRHQRGCEVHNNGGKPLPGVTTANLKKRGRKPKAVHQPSHSAPPDVTDPSYLAGVAAAATQQQQQQQQQGVALEDWGTVASFDSDPGLDSAYWNCPLYSNSSTPGTEFDAYPGIPLYENGNHSNQQIPQENTSSSDWNNFFQQHNQQQQYHQQQQQTNESFSAWLDALSCSYIQPSAILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T2</accession>
    <name>I4Y7T2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_70184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959953.1">
        <property type="nucleotide sequence ID" value="XM_006959891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T2"/>
    <dbReference type="GeneID" id="18475697"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70184"/>
    <dbReference type="HOGENOM" id="CLU_1887357_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T2"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM20024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="135" mass="14859" checksum="DEE88DF0BCA338D7" modified="2012-09-05" version="1">MTGPLPTLEPRALSSLTINQKSILELNGEKDLFVFKLDNIACHKPTKEIYEEEASDGSSKSQLVASKYITNSSTPSQMTNRQPLACTGCRKQKLKCLGGKPCQRCNKRGIECVYDSVIRRRGPDKVAGGRLKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y7T9</accession>
    <name>I4Y7T9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_70191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668243">
        <property type="protein sequence ID" value="EIM20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959960.1">
        <property type="nucleotide sequence ID" value="XM_006959898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y7T9"/>
    <dbReference type="STRING" id="671144.I4Y7T9"/>
    <dbReference type="GeneID" id="18475698"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70191"/>
    <dbReference type="eggNOG" id="ENOG502S54T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485023_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y7T9"/>
    <dbReference type="OMA" id="KAYHFDC"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="492"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="562" mass="60498" checksum="BB52C59E6E90BDE0" modified="2012-09-05" version="1">MPFCSRCGDICKPGDKCKKCGGSAVSGQVKWPAESKKSDSWIRTYVKASNRKDVFTNHTEAPKKEHIECPSSPLLETADGTLTKLVGSVLSPETPLTHPFCESCAVRFAPNATLYIHPDDDAGSQRARAYCYHCFVAYFSKGTCVVCSKAVLGEVRVEGKYVETSAGIFHAKCFECDGCGVDLSKDPIVDLSGWPCCSGCFDGSVARAEARRKGGKQHRKTTSFDPAIRGLNNRLGLSVSPQTSPSRRSGRLSQLETDMSAVSLNSTPEKEGSLASLADVASKTSKERRLSARDIVTGRSFEGVTKYASPPPSPPKKRDSIETFPRPSQVRSRSQSIDNTDICKSCRLEITTTIVRVPGEGVFHSACVKCAQCNTLLANEESDKMTVMKRPSDGKLVHVGCLPGGAMPASPSKSPLRATNVANDINTSRSVYKTPPKGVSKAPIHATLTPSPSTAVKPVPRTTKTPSPTKQQKSIWATRSSPFSSSAFGGMSSCPSCGDKLTLFECTPGPAGTKYHKKCLICRGCSKGLDSFAKVDFDGYVWCRGCFDTYVPKPRPMSYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y827</accession>
    <name>I4Y827_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_48061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959840.1">
        <property type="nucleotide sequence ID" value="XM_006959778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y827"/>
    <dbReference type="STRING" id="671144.I4Y827"/>
    <dbReference type="GeneID" id="18472438"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_48061"/>
    <dbReference type="eggNOG" id="ENOG502QTKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028866_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y827"/>
    <dbReference type="OMA" id="EITQVAH"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="366" mass="40406" checksum="A6A4B2FAA89F72D2" modified="2012-09-05" version="1">MESVLKVGLVGAGEVAQTIVLPNLRLLSHRFKVEAICDISENAIDHVSAKFNIDKKYRKYQDMLADNDVEAVMVLAADEFHAQIAIDALEARKAVFIEKPMALSVQSADAIIDARNRTNGVVFVGYQRRYAEAFNQAVEIVRSMDKISYARVRDIIGPNSIFVGQSGTYPQKFSDFSPEATEEMRLRSKQIAQEALGTSDTSSKAYGLYRLLGSLGSHDLSAMREILGGIPKRVLGVSNTAPTNAGGFLTALFDYGDFVATYETGVDEVGLFDAHIEVYGGGKRVRVEYDTPYVKGLPIKLVIGETIDGAYVERVIRPTYEDAYTIEYNAFYDAIRHGKPIKTTAEDAKQDLAIFKMLTDAFAQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y842</accession>
    <name>I4Y842_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_55261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959855.1">
        <property type="nucleotide sequence ID" value="XM_006959793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y842"/>
    <dbReference type="FunCoup" id="I4Y842">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y842"/>
    <dbReference type="GeneID" id="18472723"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55261"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="InParanoid" id="I4Y842"/>
    <dbReference type="OMA" id="AQLFCGN"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM20134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="524" mass="57138" checksum="66DD069FBA54A751" modified="2012-09-05" version="1">MDQQQPPNPTLQVAAKSFEDLVDTESGKANSDDKLQPLQDNFGYVQEMPRNRSMASILFLAVAIAAIPYGLSTTIIYPLTNGGPSAVIWGWVFMACVTQAVAISLAEICSRYPVAGGAYYWSYMLSPPKYARIYSYICGWVYLVGNWTVTLAVNFGTTQLFLAGLNILYPDFVANQWQTVLTFWALTIVTTLISCIPGKYLKYIDHGCFVWTVAGLITILVALSVRADAGRRTAAWVFGYFNNDGSGWPKGWSFFVGLLMGGYTLSSTAMISSMCEEVTDPEVVVPKAMIANIPLSFGTGLIFLLPLLFVMPDITTVLEWPTGQPVPAILQLAMGYPAGAFGLFFILFLIGIFSGIGCTTAASRLTWAFARDNAIPFSGIFKVVNKKLELPLNAILFSTAVQMVLGCVYFGSSAAFNAFSSVSVICLGCSNLVPITISFFEGRNAIADARFNMGKIGAFCNVVAILWFSFAIPLFCFPTTTPPTVDEMNYSSVVFAGFVAIAVIYYYAQGRRTFTGPPTQHYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y849</accession>
    <name>I4Y849_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WALSEDRAFT_70109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668242">
        <property type="protein sequence ID" value="EIM20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959862.1">
        <property type="nucleotide sequence ID" value="XM_006959800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y849"/>
    <dbReference type="STRING" id="671144.I4Y849"/>
    <dbReference type="GeneID" id="18475689"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_70109"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276815_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y849"/>
    <dbReference type="OMA" id="WFDPISF"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="110"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EIM20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113964" checksum="2E8856EBB23EB02C" modified="2012-09-05" version="1">MNDWSADAVIDQLLSTNNLPSRTALIAAIIAILLYLQWQAIIVVVLAGYLATSQHFSILVKTLLHDDNSIELIRSQSDEGVVESREAALKSLPGLLTRQKSSSGDKLNVLPELSEPLDSTLNLVIRDFVEWWYIPLALDPPDMAFPRECRRSLNHITSSICQRVVDGRSGTDIAIFLFCSTAQTLLRGLRTRRMPNGKLTDKIEPKESQDYHPLLRNTAAQILSLSSSHRDAENPALQSLLTEIVAGQIEAVVQILTPDWVNLTVIAFFEDEKKEQRVREEAERMRQKVEQVVNADTIPGEFKDDIETSDETKQNEINESNVKNEKNDSDIPQNDDNADEKPAVSDTTMMEKRPPHKETHHGQKPSIYIPPKKEPVPLEEGDLGETPSDKKPSVISPFNKQLHDSFGDIGVKDKSEEDTGDTPSLRDVLSHRNDSDVYDDFERFLEMRRREGLLRLLTQVTTFKEIVSITSPSEPIFRQDAIALLARAEEAVLPGDTLLLDSINATRMKIEVDASLNAFLPIEVEIYTNLESEYATFVNIKRDSVSNSSNTHSFDYSQSQSTARTSIEPRMSKEYEASYYQRQTKVDVTDLSANAQTGDFVNGKTLELMIAIEEEGLPGWMLFRRWNEFEKLDNALQKAFPMAGTASFPKAYLPTLKFKKSEDICALLGAYIKTLLIDPRYSESAIVTNFLKKEQTETTAKSSKLFNLTQPGKTFTEFAQAVSDIGVNKKRLSFPGPMKLGENRTTVAPSTQSKEQLGTISSEAINEVDKTPSEEVDYKNYTNLGQDEKEEEEKSSSYSENDAEEENEVPSIAVAETQEPIVESPSSEGATNEAATPNGAATPVTPTSPSKSSRIVSNINDEDLNLVLNSIFSILEEAYQLSGQQWSLRRGFFRVLERVIRTSYSSTVRLALQSIVEGVTEVKNVSQLLNSLRDALWPPPQREWVTAEQNTRTEEEKAETRELAKKLLVNNKPRALSGAMGDSATREAVILLHELFQDEEFCKEIATLLALDLLRVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y889</accession>
    <name>I4Y889_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_55160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959669.1">
        <property type="nucleotide sequence ID" value="XM_006959607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y889"/>
    <dbReference type="FunCoup" id="I4Y889">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y889"/>
    <dbReference type="GeneID" id="18472718"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_55160"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="InParanoid" id="I4Y889"/>
    <dbReference type="OMA" id="NEGTHFQ"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="56"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="307" mass="33523" checksum="EA8EA77EC2A6121C" modified="2012-09-05" version="1">MNNPNFGKFLSQLQKQARSSGGGRGPGGSNFNSGGAFAGGGGLILLALGAVAVNASLFNVDGGHRAIKYSRFYGIMRDVYGEGTHFRIPWLETPIITDIRAKPRNIGSLTGTKDLQMVNITVRVLSRPRQEELSTIYKELGTDFDERVLPSIVNEVLKAVVAQFNASQLITQREMVSKLVRDNLTKRASRFNIVLDDVSLTHVTFSPEFTTAVESKQIAQQVAQRAAFLVDQAIQEKQSIIVRANGEARSAELIGEALQNNKGFLHLRKLEAARDIADVISNSNNRVMLDSGSLLLDVQNLDPSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y890</accession>
    <name>I4Y890_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959670.1">
        <property type="nucleotide sequence ID" value="XM_006959608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y890"/>
    <dbReference type="FunCoup" id="I4Y890">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y890"/>
    <dbReference type="GeneID" id="18474301"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61041"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="InParanoid" id="I4Y890"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="770" mass="84112" checksum="220E60AF12591126" modified="2012-09-05" version="1">MSVVGLDIGSYSSVIACARSRGIDIICNEVSNRSTPTMTGFNVKSRTIGESAKSAETSNFKNTASQLKRLVGRSASDSEVMDEQSYIGAPLVDAGGEVGVQVSLAGEQQVFSATQLMAMYLGKLRDTAQTDIGTKVSDVVVSVPGWFTDVQRRAMLDASKVAGLNSLRVMNDLSATALGYGITKPELPEQGQPPRHVVFVDAGHSNFQVSVVAFNKGTLEVKGAAYNRHLGGRNLDKVLVDHFVNEFKDKYKIDVYSNAKATFRLAAGCERLKKVLSANSVAPLNVENLMNDIDATSMLKREDFEAAAADVLKGVETPLAEALEAAGIDQSQVDAVELVGGTSRVPAIKEKISAFFGGKTLSTTLNQDEAVVRGATLACAMLSPVFRVREFSVNDINLYGIKATWDSPSSLPEGETDETEIEAFPTRNAIPSTKILTFHRKEPFDINFQYANPASLPTGINPWISKATIKDVAPTADGDFSIVKVKVRLNLHGLVSIEGAYTVQEVEQEEQVPVKVAEGEEPKTETRKVKRTVKQKDLTVVGGATGASESKIAEYTEKEGQMYAHDKLVAETEERKNALEEYVYDQRNKLDDRHAAYATPEEKEVFKKALNEAEDWLYTEEGEDAQKSAYVARLDELKKLGDPIVNRYKEQQELPKAAAVLRAATNDFLSKAQSGDERYSHIAAEDIQKVIDTAANAAKWLDDNMYKQSEKMKTENPVISSAQVLKTAEEIGYTCNSILNRPKPKPKTEAPAPEPEPKETEGQKDNMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8C2</accession>
    <name>I4Y8C2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_61058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959702.1">
        <property type="nucleotide sequence ID" value="XM_006959640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8C2"/>
    <dbReference type="FunCoup" id="I4Y8C2">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8C2"/>
    <dbReference type="GeneID" id="18474311"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61058"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y8C2"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="19041" checksum="2D93372BF1860F34" modified="2012-09-05" version="1">MSFRGGGFQGRGGRGGFRGGRQSGGFQQGPPAEVLEMGEFQHAVESDMLCSATLPSKVPYFNAPIYLQNKNQIGKVDEILGPINDVYFTIKMQEGIVATSFSKGDKVYIGSDKLLPIERFLPKPKTEGAKVAKPARGGRGGARGGARGGFAGRGRGAPRGGGGFRGGGRGGRGGFGGGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8D0</accession>
    <name>I4Y8D0_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_29764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959710.1">
        <property type="nucleotide sequence ID" value="XM_006959648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8D0"/>
    <dbReference type="GeneID" id="18471113"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_29764"/>
    <dbReference type="HOGENOM" id="CLU_1020151_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8D0"/>
    <dbReference type="OMA" id="YIEHRTS"/>
    <dbReference type="OrthoDB" id="3361883at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="273" mass="30220" checksum="857232A57942A0D8" modified="2012-09-05" version="1">MTKILNKFKKDNAPIDFDIPDVLVTPPEDDNDSNSAELSGPFVAHRSSINSESSSVFDQEQDDDFQVRVDLIRHQSKYQTFEDLPSDDEDNDDSLVDLLQQAPIPATSVSDRGVSPRSSKIKLRIDTSISEEEESNANNNILTASTSSSFSPDTPTHAVQLPSSQSKKNSLSSPKKSLRKRISTHFQSQSSQKPHRISVTNISAPSPKLPPIAHIHEKENRDNPHVIIDQVKIRAKQLESLGFDRKVFDSDAIIHALGHGESHNQDEIVGIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8E6</accession>
    <name>I4Y8E6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_65592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959726.1">
        <property type="nucleotide sequence ID" value="XM_006959664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8E6"/>
    <dbReference type="GeneID" id="18475037"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65592"/>
    <dbReference type="HOGENOM" id="CLU_1134306_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y8E6"/>
    <dbReference type="OMA" id="TENGHKD"/>
    <dbReference type="OrthoDB" id="10493823at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="245" mass="28701" checksum="EE4141C27175ED12" modified="2012-09-05" version="1">MKDEDLAEFRIKCEEYYKTRSNDIQPVDAYFIQALPEERANLTKIQNDIRRQYHNSVAVEKKEFLRTIKDNTQSVSSDYRNALNGLKEFIDKHGTNNPGIEIFLISLYNFLRLQRNHKQRLCWVIDDGVFTEYGDNEFTLDAYKLLIRKIGLNLQIEDNEKCTYIMATNFTNSELSALSRQFPSKIKRSRRILQAVATSDEAEQGVRNINKLATGRVHISTQDREEGYESSLITELYNYFLDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8F3</accession>
    <name>I4Y8F3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_61074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668241">
        <property type="protein sequence ID" value="EIM20245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959733.1">
        <property type="nucleotide sequence ID" value="XM_006959671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8F3"/>
    <dbReference type="FunCoup" id="I4Y8F3">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8F3"/>
    <dbReference type="GeneID" id="18474321"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_61074"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_4_2_1"/>
    <dbReference type="InParanoid" id="I4Y8F3"/>
    <dbReference type="OMA" id="FHHEYEK"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="69"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="411" mass="45788" checksum="E27753414929FE57" modified="2012-09-05" version="1">MTPRSKVFQYMPSSGSSLSGMSSASDRVGLDSAAHEKYSISPVKSVSQRLLMSPRKNLRKISKLPYKVLDAPELADDYYLNLLDWSSTNILAVALASTVYIWMAETGQVMTLCNVRELEHADPEESVSSLNWTNKGSQLAIGLRTGAVQIWDVPSGKLLRVMSGHHNRTGTLSWSNHMLASGSRDKSVLIRDVRLKDHYVRRVIGHKQEITGLAYNPAGDMLATGGNDNKLYVWDTKSYNYIHRYTEHEAAVKAISWNPHHRGILASGGGTSDRRILFWDTLKGDRHSIGDWDTGSQVCRLWFSKNTQELVSTHGYSGNAYQNHISIWKYPSMSQVATLTGHTYRVLYLAASPDGQTIVTGSGDETIRFWKAFPSLNVDTNFVAGSINTTGVVRDMKHSESSSFNIKKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y8T3</accession>
    <name>I4Y8T3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_69929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668240">
        <property type="protein sequence ID" value="EIM20375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959632.1">
        <property type="nucleotide sequence ID" value="XM_006959570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y8T3"/>
    <dbReference type="FunCoup" id="I4Y8T3">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y8T3"/>
    <dbReference type="GeneID" id="18475663"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69929"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_2_0_1"/>
    <dbReference type="InParanoid" id="I4Y8T3"/>
    <dbReference type="OMA" id="CIINEQG"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="240" mass="25933" checksum="F2D469BB24CD4C91" modified="2012-09-05" version="1">MSLRAGNIRKDGRTPNEVREINCTRESNARVDGAVRFSFGDVEVLGSATGPVEANLRDEIVDRCTIDVNFRSINNVTGVQYKELADQIEGALSSVVVGEQLPRSLVRFVVQTLSSPQTPTYMVKEAVSAPPFRIPISEKAAAINGAIMASLAANIPLSGVLLCVSLAVIDDVIVLDPSSYEEADATSVHLLGFTFSSTTNKALSISESLGNFNQETYIEIIKEGSKNAEIMYNYIKTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y908</accession>
    <name>I4Y908_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_69817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959476.1">
        <property type="nucleotide sequence ID" value="XM_006959414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y908"/>
    <dbReference type="GeneID" id="18475648"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_69817"/>
    <dbReference type="eggNOG" id="ENOG502S6ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1541308_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y908"/>
    <dbReference type="OMA" id="QGTLFEY"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17793" checksum="9290D46DA03EF92E" modified="2012-09-05" version="1">MILRRKLNTVTVGTAYELAVMHSLTTQLKMNLMRVGGANDRGVDLQGCTQTQPRISLLVQCKCENKKLSPRHIRELQGTLIQHGNINTTMALLASPEGFTSKTVANAIASTLPLSLLHISTNGILHNCIFNHPASSLLNEAGLHLVKKFVGNGTDVNISLEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y942</accession>
    <name>I4Y942_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_20624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668239">
        <property type="protein sequence ID" value="EIM20484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959510.1">
        <property type="nucleotide sequence ID" value="XM_006959448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y942"/>
    <dbReference type="STRING" id="671144.I4Y942"/>
    <dbReference type="GeneID" id="18470846"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_20624"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122513_1_1_1"/>
    <dbReference type="InParanoid" id="I4Y942"/>
    <dbReference type="OMA" id="QANINHY"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="1">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="16050" checksum="24FC527F5D27CD60" modified="2012-09-05" version="1" fragment="single">DTRTTVMIKNIPNRLTTEQLEKYISDIVPRSFDFLYLRMDFKSRSNVGYAFVNFLTVDALYEFASLRINYKWLVDVYHSEKRMGMTYANVQGKEALTAKFRNSAVMEEEPGFRPIVYYSSGANVGLREEFPSELETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9G3</accession>
    <name>I4Y9G3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959394.1">
        <property type="nucleotide sequence ID" value="XM_006959332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9G3"/>
    <dbReference type="GeneID" id="18474226"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60885"/>
    <dbReference type="eggNOG" id="ENOG502S0PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465553_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9G3"/>
    <dbReference type="OMA" id="WVKDWHK"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM20605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="586" mass="64972" checksum="27227894CA7849D5" modified="2012-09-05" version="1">MALNYQQLGDRPQDLQQLQQAQARRSPRMAAALLQQRRSAAMGQPTGTPTMGMNNFDAGAGFEWNPQLQFDPGREQQIQQQRLAHYQLQQHFLQQQQMQQLQKQQMALQQQQAAAAVAQQQQQQQQQMQFNNMQRPSPIMGHYPARPSTSDGLGQFNDPMNGMGTVNNMSMNNINASEALNLQLNGSQHASPAHPPRAIPTPQPISTPQPMPTPPQGVSTPHPRPSSQPHPHMHPYAAQLQSAQMAQVAQQQHSQAQQQRIRPPMGNMPGMSNPESMAHLARVPSHTAAAAAAAAAAPRAHAGTLRLLQYIEHFRRHINVSHGGNNQQKSLGEQLSATQWHSFVQEFFMPSAMLRLNFRKLDGGNFDPNQQDMRQIRHFDLPFTTLPRYHAAWSQSEVAGITMSTPGAHESVYHTSGPTAQGLRGPNGEMLPSSMTTIATHLVQAPRAMILYTFSNGTAIRMVGHLRAALTASLPPQNTGGQQALKFETLEFDVESCVESIDRSAIQYRNGEDIPKLPECVVNEYGLPVSVMKCLEIVESVVQMQDVMNYSLRNNCGPVEALKEINKIKDTSLKKRKLEQGFDSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9I7</accession>
    <name>I4Y9I7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_60893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668238">
        <property type="protein sequence ID" value="EIM20629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959413.1">
        <property type="nucleotide sequence ID" value="XM_006959351.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4Y9I7">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4Y9I7"/>
    <dbReference type="GeneID" id="18474231"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60893"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_0_1"/>
    <dbReference type="InParanoid" id="I4Y9I7"/>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="47"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="880"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM20629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1538" mass="177949" checksum="5D3B0CF0778DF66E" modified="2012-09-05" version="1">MGLRRSNALKSSNTSPTKMNANSSVLSRTQYMTLDKQRHLLAAYEYLCHISEAIRWMEECLESSLEMDEVQAEEGLRDGIVLFRLASVWGFGEGMEDGHFGWDGIRKNYAGHRRLFTHPNARHFKYVDNINYFFEFIKRIKLPELFTFETTDLYEKKNIPKVIYCLHALSYLLAGRGVAPRIGALKGQLEFTDDQLRQTQKNLDASNVPMPNFGGLASTFGEAEPEPEPEPEETEEDRIARELFEVENKIIAMQARARGFLTRQQFANLQRRIKWSQQPVISMQATCRGALTRTRLHDIREERSGSAMKWVVPLQSAARGKLVQDQQRNIQRHFMVCKSSITSLQAQCRGVITKENYDNKKRLISRQERLGAYHKLQAHCRGMLTRDGFKKRTSTLKNRGELQRAVRIQSSCRGFLVRSKHNEFMDTIRKHEPSFLAIQTLCRSKAVRSKFQAKSKDIKGVSQGFIALQAQSRGLLYRKDHSKFIKLLKNGSSSNSVALLQAFARGFITRQSLNAFRQKLASLSKEHVIIQACARGSIVRDECESILAYLDDNHKSIVAIQALSQTALIQERYGHLQSMLDESATSICQMQSHSRSFLIRDHIENIKTELMNEPNMRSILDLQSLSRATLVRRYVWDIFQQLESAEDDVVKCQSQARGYLIRKDQKMWKRHLQVSQPEAVNLQSIMRGYNQRKKFGEKKTHYRTNKEKIVKIQALYRGREKREQFKELTMGNNVPLNTVKEFVHLLDDSDYDFDEEIELVDLRKRVLEAIRETQALESHVDELDVKIALVVKNALSFDELVRAAKGRLVASGTLNRNGSVLAAAGDPFSPGKMDKQTVRRLELYQQLFWRLQNQPEYLARLFYNMSRTEVSDKNRRLIENVIMTLFGYTQSAREEYLFLKVMQRSMHEEIASANKLSDVVRGSFTWVKMFLLYLRGPEKKGFLKQALGPRITEITSLESFDLETDPVVIWKQIINYQELESGVPSDKKKDVTYEEAISDSDTRVTFIHHLQQLRHATEHFREDIQKSMKKMPYGLRFIARELYLALRIKFKNESEDACNRTIGQLIYYRYIHPAIVTPETFDVVPKVLDPLQRKNLNEIAKMLTQLAMGEIFSDENPYLTPLNDYILDASSKFIPWFGQVADAVDAETHFNAGEFLEYNTTRKPSIHISPSEIYDVHSILNQNLDKIAPTGNDPLRGILLELGGPPLPAQGELYEARKRAVSLTLANRNAQVDNPNDPQTHKKQLWLQTKRLVLAVLRIQPERTLTQSFITEVTEEHEHQWQLFVQKESSLEMSRKSGIKDTTSPFLGSGYKINDIKQMRYTEVKATAIEYCLQLEKIGEITRKDHYQGVLNAIAVDVRNRNRKRIQRQKELNSMENTLKILDEKKDYLHNQQEAFNSYIETSMQTMQKKGKKRFVLPFTKQWSHLRDLKHNGKRFKFGSYKYSAQELYNRGLLLSIHQVSPRQFDGLFITFSSDEIGVFKIDMNLAGEPKPMASEDVRLEDMLQMQFENKSSIAICEGNVKCNLNVLLFQLYKKFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9N7</accession>
    <name>I4Y9N7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_47162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959212.1">
        <property type="nucleotide sequence ID" value="XM_006959150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9N7"/>
    <dbReference type="STRING" id="671144.I4Y9N7"/>
    <dbReference type="GeneID" id="18472410"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_47162"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_1_1"/>
    <dbReference type="InParanoid" id="I4Y9N7"/>
    <dbReference type="OMA" id="ITKMCHS"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="96"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM20679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="344" mass="38864" checksum="0009A79B3050DC27" modified="2012-09-05" version="1">MHNSTTNEFSLALNDRTIILKQDNVKELDFRSIPSNFDSDKSFIHDYFQLDTRIIDLYDDWSARDRHFKSIKDTNKFDGILILRQDPWECLISFICSSNNNIARISQMITKLSTTFSEPLGDLDEIYSRYPFPPPSKLAGEDVEDTLRTLGFGYRAKYVANVAKMLVEEHGSDENIFTYLHSLRKESYENVIPQLTRMMGVGPKVADCVALMSLDQHSSIPVDTHVWQIAVRDYGFLKSPYVKSCKGKVSQSSAMSPSIYAAVGKMFRDLWGPYAGWAHTVLFAADLKAFKEESPSVKDENDVVPGVVTSVVSPEKKTNVRPKRVVDSVKKEPSKASEKNLPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9Q9</accession>
    <name>I4Y9Q9_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959234.1">
        <property type="nucleotide sequence ID" value="XM_006959172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9Q9"/>
    <dbReference type="GeneID" id="18472971"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57991"/>
    <dbReference type="HOGENOM" id="CLU_1714727_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9Q9"/>
    <dbReference type="OMA" id="RRNAKGM"/>
    <dbReference type="OrthoDB" id="3364362at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="153" mass="17431" checksum="CF8B179F7D74B120" modified="2012-09-05" version="1">MTNNFFNNQYDTNLNSLTQNEAVEALYLEWKRDQQIAKAKVLAANIDIFFGGMPVSETSSIVSAQSRERNSVSLTRFIKRTCAKIFQKSKPMRSFENSTDEGSIGDSHQLTSTAIGHSNAIDRDRRNMKGRGFNISDFDLMLLETNYNIYNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4Y9V5</accession>
    <name>I4Y9V5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_65167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668237">
        <property type="protein sequence ID" value="EIM20747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959276.1">
        <property type="nucleotide sequence ID" value="XM_006959214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4Y9V5"/>
    <dbReference type="STRING" id="671144.I4Y9V5"/>
    <dbReference type="GeneID" id="18474996"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_65167"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311964_0_0_1"/>
    <dbReference type="InParanoid" id="I4Y9V5"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM20747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="941" mass="103558" checksum="D9B5D1CBB74B0F20" modified="2012-09-05" version="1">MFDPKLSIVPDDNNIYMFGTTRTCSQYSLSGNIIISIPPLERKQLRIHSLSVTFQGAAQYSDSQSRLSNYRLAHCSDQIVKRTNAPHVFENDSNEFINVSVFFDLRLNGWLPPSISLPSSRTSYGLFAKMECTIEPIEHSKRSSLLWPLNNTIKKLTVLAPESEIYITRHRNQHQRSRVHNIRSQCPTHDIKDFKPVRIGIKTPMWYFTDDDDLKLDIFTGLVNDDSDESTEARLESLQLGCVEEIHYTSEPRQRYLQTYPLPQCQPPTYPLIPFNNSLPEHTLNDIASTLGISTMPTSYTRSRLVARGVGPPPATAAFATHTFGEEGVNISGKLTARIALTLPMPTKEERSSDKVNPNGCNSSPYPDCETPFVKVRHALRLILNIIRKAPGDEEWRGESIDITIPVWFSTRSSDSQIEVQAQRLALLKSKGLLPHSNLPAYSQLYTDQGAQVEDEEAPPRYNKNPEPNEETLLSGESLRRTNIPPRWDKLFDSNSNKYYYVNYNYDPPTTQWKKPNKLKLKLKRVFSHPGGSKERQKREIKGTGQAKGFAVPMGINCVGLSSAGLLDNLSSLTEGHYIMSFKPDVDQSKHYGLLENLLGSQSSIKHKYDGFYNGYALNMGSNLLGGLLDSLLGDIADMEEDVEVEAYAIQDDATWNLQRIIQRDALPAGSDSHSQDYQYAYTGDGSGVDVYVIDTGIRVSHDEFEGRASYGYNGTSGDGSDQVHHGTHVAALIGGKTYGTAKKANLISVKVLDANGQGRASDVLAGVNWAVNQAKSTDKPSIASLSLGGPGSNAMDNIVNDATKSGVHFVVASGNYNEDACSSSPARVESAITVGASDISDRRAPFSSYGDCVDLYAPGVDILSAGNENDQATLYLNGSSMSAPIVSGMLATIISNEGDISPEDMQNRINDLSTDSIVSESNPVNKDAGNATLAYYNPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>I4YA41</accession>
    <name>I4YA41_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_57897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668236">
        <property type="protein sequence ID" value="EIM20833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959095.1">
        <property type="nucleotide sequence ID" value="XM_006959033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YA41"/>
    <dbReference type="GeneID" id="18472962"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57897"/>
    <dbReference type="eggNOG" id="ENOG502QR34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028833_0_0_1"/>
    <dbReference type="InParanoid" id="I4YA41"/>
    <dbReference type="OMA" id="DMRYQVH"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM20833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30437" checksum="1BEBD48C7BEDF3CF" modified="2012-09-05" version="1">MSSSSSSEQKLLDKFNKVTESTINSRYFTSILQQLKRELYNKNYIDAFNEEEFLEAYLARYVPSRSIIYYRMFKEMNIKDNAKIISIGGGAGSEMAGLQHYLEDNDIKGVKLDILDIGKWDRVIDKLGTTFRESLAVDFYNKDVLSDEIDYTGYNMVTLFFTISELLIQSKKMTFKLLDNLNSCPVGTEFVVIESCALSNVMINNKEYSIKFLLDYNLNKKWQLINYTPSRWFRLEEDYKYPIKLENSRCFICIYKKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAC5</accession>
    <name>I4YAC5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_64812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958915.1">
        <property type="nucleotide sequence ID" value="XM_006958853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAC5"/>
    <dbReference type="STRING" id="671144.I4YAC5"/>
    <dbReference type="GeneID" id="18474959"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64812"/>
    <dbReference type="eggNOG" id="ENOG502QWMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004538_1_0_1"/>
    <dbReference type="InParanoid" id="I4YAC5"/>
    <dbReference type="OMA" id="AENGPPC"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="960"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112554" checksum="D63A65A63DE4AAD5" modified="2012-09-05" version="1">MDDYQPEMQEFEDYSYQYTEDDSNRKRSQHSDIDDDATKKRRTQQPQRRLNKDGSEKPKLSRGSRACLVCRRVKMRCIGASEGVKCKRCSNGGHECIFEESNRGRRSTKKSDQLSSSLKSMGETLGGVLKNMAPGTPPSEQSPYSQFSPANSAEASTSRLAVPPYSVNSMDSQTQPSMSNYGRPMLNHQAVKTLEKLMGGTQAQQIEAASWIMQFQESVVHFNNQILDQNLKMERLQSKQLPQPGGHLSKGVTPLDQLVSAFQVSSPKLGSTLERQESTAAPMSFPTPAYNRQASFDKPFDRPAAIDKLKLPQNVPPQSPKLHSLPDDTLNPLGLLAEASLNNRRYTMRNSQRPDLTTILNNNEEKDENGTKISEKERNEQVEALVKAQNLEGIGVASEEYYRPGPMSMLPLRRIFIERQVRPEILSFCTEDNIKDLFTIFYRHLNMHTYILDEDFHTPSLVASRSPFLLTAICAVSSKFYDKEPALQAKLNAVARKLAFDVPSQGFKSVEIVMAYLILVYWGVGPSRRFEEDKTWLLLGLALRVATDLNLHRKSSLSSMPGINDVQREQELRCRERIWILCYITDRSLSSQMGKPSSISLREDYIIRHVSDWARQSSGNPRDYCVAAYCELQRIVSRFIDFHYSSTATPSGLGTDINYMLITVMFESQLLSWYESVINANETIVCSEEQHDYIINVSKFMFNYWTLAIFSFGLQSALETNSVDFTYFFTKCYHSAQELLLITKEVMAPRGWLKYSVDSHFVFITYATVSLMKFMRPQFSPYHSVIGIDNSKIINQVSEIASLLASVAVDSKHTPALYAAFLQALIGPPTTGHDDDQLKNRNEIFDKLMTDDIDKETTLKQSNDENHGESANGLMDEGSTYMPPPITSMASQSDEYGSAAGFEGTNVDYISMDLNALNEQAQAMDALYQNGFWENVLLPGFGGPLDSISGGVMRSGYLTPKGITPSQTPRNISRPQTPGTTSQQYVKPKHRMNGMMPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAM7</accession>
    <name>I4YAM7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WALSEDRAFT_60682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959005.1">
        <property type="nucleotide sequence ID" value="XM_006958943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAM7"/>
    <dbReference type="STRING" id="671144.I4YAM7"/>
    <dbReference type="GeneID" id="18474095"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60682"/>
    <dbReference type="eggNOG" id="KOG4640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385039_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAM7"/>
    <dbReference type="OMA" id="PACERIQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="210"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="718" mass="81946" checksum="5454BE8DF6C951E1" modified="2012-09-05" version="1">MDLLVLFNKQSTKLYRVNGSLIWERDLAIDQLRWSFDGKFIVVLDKINNIHLLDVKDGSTFYQFAGGDICSIDAFKVESPTRNKSRFTFLPTLNALPDVSKSINQLLPFRLPKMEKKDGDYVKTLIDKGFPYIPIDSTSVAMNVREETLIDSSESIIVCRYNKQIQIYLQCTLKLPLIPLPKLLQYDNMVITPQLDIYTLTHYGKIAIPRDIHHLGALSSQLSMVLSYALEGVTRLTKLYADNGGPRSESLKWSDKIGEFMRPHCPDTPELGLIQLLLMGTTSKGLREFISESLTDRTLEKWSTTVLTSLNQMQSLIFYNIVPSLERLLVMLEELQSITSAPDRYQDIPINHTTLDQIIRITISLCNRLWDITVIISNKVINFSEFTKFLKYQMAKYAYFNQDEIDEVVSMPKPEFDIMAVLQYLQSGFAMIELDEYLIKNDHPVAFNDENMDVKVDINKVLEKAQRNLKDASRLVEGKETNDRRVSGSGLPIKGRHSRGRHSESPTNTKRQSDLLSTVNWLSEQLQLLLCNAVDKCDVRIELNERPQISLPDTIHIFRDSIVKAENGELYQNIAYSLPLSEEQNDSEITLLRCKLDNHSDWQVQQLHLPTTRVVDYGYFDDEILVVLVFDRESSDYVLANVPFNNLSYDGSRVVAPLDKQRTLSKADEPVSRLALNGLPGRRISALSSNDGYGCLVFDMDGDEMESEGEGDEEEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAM9</accession>
    <name>I4YAM9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668235">
        <property type="protein sequence ID" value="EIM21021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006959007.1">
        <property type="nucleotide sequence ID" value="XM_006958945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAM9"/>
    <dbReference type="STRING" id="671144.I4YAM9"/>
    <dbReference type="GeneID" id="18474096"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60683"/>
    <dbReference type="eggNOG" id="ENOG502RX8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376066_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAM9"/>
    <dbReference type="OMA" id="NMSADWI"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71867" checksum="313B90B4F6F82893" modified="2012-09-05" version="1">MIPLHHRPYHQEDRFLFLRSRRSRLREPDISQDFMLITLKSLHKPVIERHTQLSPIYQSIKSASQPSTTDDGVWWLDIKSPTWDDMRSLCKVFPLHPLTQEDILQQDTREKLETFPALGYTLIVFRGVDERYFRLSDPSSGLSRKADDVSLEHLSPDIHLNDVADDNIGKKRMRIVEGVGGKEGVEGVGVGGINVYLLIFEKGVISFHFDNIATHTDRIIRRMFAEHSKVSLVAPEWIAHGLLDSLVDAFLPLIEYVERETDEIDDLVVDPRGLSTKDNTGADHPERHSEDTFVNSEKDKYDQSPDSLAYAKKFELPPPPTTPKRAQSKMGPLAPLLSGIMDGSQLSEWREKRKAKKAEQDRRTKIRRYNTDETLSKSVVIDVPPTPSPPVEEQPKEEGILTKILKLSFLRRSGNSPKSLIPEEIRFLSFFPNSQSHLLQRTTDTRRLVTGLGRLLSAKSDVIRQLRARMIEKRKSLKDPNQSEALREMIVHFGDIEDHVVSSTQTLMHDERVLSSLHLAYLAQLKLGHAVSKSGSDNTILALSVITVCSLPMMVITQAFSMNVTTPRNGVPEDPEENGPPMVNSDGSEPSYVIFGCIVVGLACVFLFVGLLVRYWILQARKEGNERRRRRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>I4YAW5</accession>
    <name>I4YAW5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_32851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="JH668234">
        <property type="protein sequence ID" value="EIM21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958785.1">
        <property type="nucleotide sequence ID" value="XM_006958723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YAW5"/>
    <dbReference type="FunCoup" id="I4YAW5">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YAW5"/>
    <dbReference type="GeneID" id="18471570"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32851"/>
    <dbReference type="eggNOG" id="KOG2511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_0_0_1"/>
    <dbReference type="InParanoid" id="I4YAW5"/>
    <dbReference type="OMA" id="IEHCLEY"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="154"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="395" mass="44725" checksum="0DBC61A1470B6BB7" modified="2012-09-05" version="1">MQQAVLQHFPDTRVSYRFTNRSMQMRFNGKCLDAINEGLHFLSELTLQPSESGYLRSDKAPMFKPSYVDYLENYRFKPSEQIEVRLVNVDESGFGDLEIDIRGLWVETILYEVPLMSIVSEAYFAHVDTDWTYDGQAELAKAKMRKLAEGGIILSEFGSRRRRSLQGHDIVIRALKEESELLSGQKAITGKLAGTSNVYFAFKYDLPPIGTVAHEWTMGIAAMTGYPTANFTSLKLWEQTFGNSLLIALTDTFTTDAFWREFLEHPEKARKWAGIRQDSGDPVKFCEDAKRIYEKLGISPSEKTIVFSDSLDDELCIKLKKVTDDYGFKSSFGVGTFLTNDYRKASNHEEKSKALNIVIKIASVGDTPTIKLSDDLSKITGNDNTVKTVRHELHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>I4YB54</accession>
    <name>I4YB54_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SrrA</name>
        <name evidence="13" type="ORF">WALSEDRAFT_64781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
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        <text evidence="8">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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            <end position="527"/>
        </location>
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            <end position="349"/>
        </location>
    </feature>
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            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
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            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
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            <end position="56"/>
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        <location>
            <begin position="66"/>
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    </feature>
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            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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            <end position="578"/>
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    </feature>
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        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBW2</accession>
    <name>I4YBW2_WALMC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_16"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
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            <begin position="249"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EIM21454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="473" mass="52592" checksum="190AF08E1D9D76C9" modified="2012-09-05" version="1">MTDNKKRQREESPGKTKTKKSKVAIEMYEPAILTHKQCLLATFYGWDSQALDEESENAATVNDLSNVIQGSVLHGEGNSALVVGGRGTGKSLAIQSALSLSSEERFIPIHLHGSVQTTDKMALREMARQIRNRGGTVSSLDALDKEDHLIDISQSTLTALLTLLSASALPIVVILNEFDLFATHARQALLYCLLDCAQGGQRRGGLAVIGTTCRYDAIDMLEKRVKSRFSQRVLHVSSPRTWTEWSTLARNALSCEVIEGVPHMSAFEHKWEIHINALFKDPQFDLVLKMLFDMSADVQTLYRVLAIPIANMTTETPFPSAKDFLLASMSQRPIDAHQLIDTLPLPALALVIAAKQISSRDIDQFTFELVNKEYDDWARKTIMAPTSRSIDITSTGARVNISVWPKHVLMGAFDTLVDLNIFVPVASANAIASGEMREYCKHRCSIENGEIRQAVEKRKDIPTALYKWGHSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBY0</accession>
    <name>I4YBY0_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WALSEDRAFT_32657</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958501.1">
        <property type="nucleotide sequence ID" value="XM_006958439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBY0"/>
    <dbReference type="STRING" id="671144.I4YBY0"/>
    <dbReference type="GeneID" id="18471537"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32657"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="I4YBY0"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="114"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EIM21472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="488" mass="54400" checksum="C5150DD0B3D7434A" modified="2012-09-05" version="1">MTGEIEKTTNEKMFTAEEVSQHNTKESCWIIVHGKVYDVTDFLPEHPGGSKIILKYGGKDATAEYDPIHPPDAISENLPPEKHLGRIDPMTVQDRIKETSQEEKESAARHAKKPPLGECLSLHDLEAVAKYVLTGKAWMYYSSGADDEITMRENHNVYHRIWFRPRILRDVANVRFDTSILGHKTSMPFYITATALGKLGDPVNGELNLTRSAAKNGIIQMIPTISSCSFDEMIDAALEDQVQFLQLYVNSNREVTEKFVKRAESRGVKGLFVTVDAPQLGRREKDMRMKFEDVGIARTISTLIDPSLQWSDLDWLSSITKMPIVLKGVQSWQDAVIAAERGCAGIVLSNHGGRQLDMAPSGLEILPEVVEALKARGLYNPSKFEIYIDGGVRRASDILKAVALGAKAVGIGRPFIYAYSAYGEDGVNRAMEILRDEFEMCMRLLGARSLEEVTPEMVNTANLNALAVPKDNLFYSNYERLSGLNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBY9</accession>
    <name>I4YBY9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958510.1">
        <property type="nucleotide sequence ID" value="XM_006958448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBY9"/>
    <dbReference type="STRING" id="671144.I4YBY9"/>
    <dbReference type="GeneID" id="18473954"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60455"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060788_1_0_1"/>
    <dbReference type="InParanoid" id="I4YBY9"/>
    <dbReference type="OMA" id="KCVEYDP"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="64"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="237" mass="26105" checksum="B470A6EBF090C8CA" modified="2012-09-05" version="1">MNSTKFQGGTGSVPPRSQTVSNDRIGYRRKVGFDSVDEYLTGHPLSTLTLQSTTSDYKRSKNTRTFLVGASTDVNGQRALDFVITNLLENGDEIVAMRVFDDEPRNQENARDEAEELLESIRIKNDEFENRQISIVVEFISGKITTAIRSLIALHRPDSFVVGSRGKSGTWTQISSAFASVRSGSGTAGGMGSVSRWSLSNSKVPTIVVRNDAKVKESLAKRANNSKRRSYHSLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>I4YBZ6</accession>
    <name>I4YBZ6_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_60461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958517.1">
        <property type="nucleotide sequence ID" value="XM_006958455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YBZ6"/>
    <dbReference type="STRING" id="671144.I4YBZ6"/>
    <dbReference type="GeneID" id="18473959"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60461"/>
    <dbReference type="eggNOG" id="ENOG502QX51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014674_0_0_1"/>
    <dbReference type="InParanoid" id="I4YBZ6"/>
    <dbReference type="OMA" id="HHITESE"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="839" mass="95167" checksum="2FB4CF0DAF94C4BA" modified="2012-09-05" version="1">MDEVVARQQAHISKSQAQENNSRSIVSKRKREQVIQQEEPLYQEPLYPQRQQYVREPVYDYEEDEEDYRPTRQRQPVVEERPPAKVKSSSDREKEALFVYKDLDVYDAQGSLKVTSDSVYEALSKSPRFSIGSHVYQPDSLVDFYPHQVGGVFEMYVPGAWLGDNWAVRELLPQKNGDSVELTPKVRHVKGKTSRLALTDLDALDERRIWGTDVYTDDSDPVAIAVHLGWLFDASDKSYDRRLLVGAGRPAEGEKVDDVIEDADLVLVFRVAPRLVAYHSSMRHRLWSRGWGNQHDGFSLVLEECRLVPKEKDNVVRPSKQLRKARIALIAEARKTIMDSPSLKVKEGDIDYNAADENDVWKLLSEDHKTNEKVKFNKGGIKMIKRGDRRFKRVEKDESEKELEALLAIQQGRELLEAQARAEEEEKSKAEETERKAREEEKRVAEEAQAAQEKEKNELLQAGEPQPMEEPPAESEQPTRQEQEQQTQDVRASLQNDELPQLEHQLEHDETNQNEVSQQEQSVQQEMSVEHVEPRLQDQPTKEEERIQHEHQVQQEEESLQEKPLVQEQSLQSEQQIPSQSNQPKVQSDQVGPEQMQSVEQMQSSHENQSEQQLEQPIKQEAHDPVQSEAVTEDVPAPVSSSAPTAPQEIQHVSMDIDRSAPVEPIQEETKTFSVEEASTQQEQPQTFTISQGPVYEPVEPVALSEPSAAQPESDVSEIKFVNHDTVEAPNQEVSASQTAPQGDALTMQIAQAKQALEANESSASRTDNTLDPGRTETNYEASNQQPVANEQNYFNVATSQVPQSSNSQSQVQLNEDTTSINAPPTTNVKETEMNPPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YC43</accession>
    <name>I4YC43_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WALSEDRAFT_9735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668232">
        <property type="protein sequence ID" value="EIM21535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958413.1">
        <property type="nucleotide sequence ID" value="XM_006958351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YC43"/>
    <dbReference type="GeneID" id="18475854"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_9735"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_4_1_1"/>
    <dbReference type="InParanoid" id="I4YC43"/>
    <dbReference type="OMA" id="TFICIEC"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EIM21535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="81" mass="9161" checksum="01E552D2B5A0EF3E" modified="2012-09-05" version="1" fragment="single">ERNHRRLLDIIKVPGNQNCADCKASNPRWASYSLGIFLCMPCASVHRKLGTHISKVKSVTLDNWNREQVASMEHIGNSRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCP2</accession>
    <name>I4YCP2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_32336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958045.1">
        <property type="nucleotide sequence ID" value="XM_006957983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCP2"/>
    <dbReference type="STRING" id="671144.I4YCP2"/>
    <dbReference type="GeneID" id="18471468"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32336"/>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_11_0_1"/>
    <dbReference type="InParanoid" id="I4YCP2"/>
    <dbReference type="OMA" id="DWAHKLH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="98"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM21734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="349" mass="38815" checksum="BE51A0138A39D51F" modified="2012-09-05" version="1">MTITLENKHLALGAASLLATFQLYRTFSSIFANTKPTKHTNGFSVQVERGLGSLDPDSELGKGVNEVYPPDAFEGGSDVRLPNGRVKYYLLGPEEGDKIVLVHGFSSPCLVWRELGTSLANAGFRVLMYDHYGRGYSDHPIVPYNGPLYTTTLALLMNHVGFEKAHICGYSMGAPISISFADIFPHMVSKIILLAPAGLMDPTPFRLTRQIDPTSFIEAPSWLKRLMRPSGPVNYDAKSMPENVRMLAKLSEIQSKRPPFVHALLSTLREGILFDQDEIYKAIGRRRKNPIHIIWGTVDKIVPYSLSERMLEYLPSATLDTIEGAGHDLVITNSEHVQKSIIDFLNGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCQ9</accession>
    <name>I4YCQ9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WALSEDRAFT_68682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958061.1">
        <property type="nucleotide sequence ID" value="XM_006957999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCQ9"/>
    <dbReference type="FunCoup" id="I4YCQ9">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCQ9"/>
    <dbReference type="GeneID" id="18475452"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68682"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCQ9"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EIM21751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="60" mass="6775" checksum="631F45174173AA94" modified="2012-09-05" version="1">MYSIAPITGKFRKSVIRDISVSLGLGTALGYAYWWGVHLPANSQRDQFYLKLAKEKEANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCR8</accession>
    <name>I4YCR8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_60229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958069.1">
        <property type="nucleotide sequence ID" value="XM_006958007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCR8"/>
    <dbReference type="STRING" id="671144.I4YCR8"/>
    <dbReference type="GeneID" id="18473825"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60229"/>
    <dbReference type="eggNOG" id="ENOG502SRCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652477_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCR8"/>
    <dbReference type="OMA" id="QLACERC"/>
    <dbReference type="OrthoDB" id="2260578at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47798" checksum="9C9578A69101BE29" modified="2012-09-05" version="1">MGRPTKKTDNYDCFTLFAHGVPLIDGKTVCEDLDLVYYSALTISDNLRGLDPRNRRASMINAADEAIKSQKRDLRTLIGLIYTIHDDYGRNDITLAQDHIQYASRVALELGLNTKTPFLTPGDRLNSIYGRIWWELYILDVFLNLSTSGTVTRQFDSYMTISVDIDDVASDINLQQAYDSRIKAVSILNECTKVNGRLNFERVSALDKILVNLLTVARSNYHSAIDKTIEELNFTSILILLAARIHLHRQAWFSDMTFNFQSCAFNHKMKEMEMLLDDAFVMPASCNLEDSLSGSLTAIHECTEQMLHYIRLDETHQTQQGILIPPHWPFYSCCQLVASYGPILEIALLNAIRAGEQGALQNMTMDPSSVWKTRVALSNVDLTYATLTRYMSVWKVAQIYREEVAVCRKIIDSCETDIFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>I4YCW5</accession>
    <name>I4YCW5_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dipeptidyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WALSEDRAFT_64041</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958111.1">
        <property type="nucleotide sequence ID" value="XM_006958049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YCW5"/>
    <dbReference type="FunCoup" id="I4YCW5">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YCW5"/>
    <dbReference type="MEROPS" id="S09.006"/>
    <dbReference type="GeneID" id="18474897"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_64041"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_0_1"/>
    <dbReference type="InParanoid" id="I4YCW5"/>
    <dbReference type="OMA" id="MRTPQEN"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="15">
        <location>
            <begin position="155"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="14">
        <location>
            <begin position="620"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EIM21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="93886" checksum="3FBB89BE9846B86E" modified="2012-09-05" version="1">MSSSDRNYERDTRDEQEQLIYSNDIPELESQFEKSDGQTRRYWIIPVIIVSITAISSIIGTIAALTYQHHFGISSRHHLPLTLDKVFDGTFNPVHHNIKWVNQQNSSHGMYGVQDDNGAISLVNVSSNTTKTLVQPGEVLDIDGQPLEWDGWSLSPDGKFILFQTDTIAAFRYSNYANYYIHSLDTRSTHPLTQPTNPGSISLAMWSPSGHALAYVRGNDLYVVHARDIPKETSKAIRVTDSGTDSVFNAVTDWVYEEEIFNSHQASFWNQASEMIAYLILDESKVKEYKIPVYNPTSSSDNIEQYPQELRIKYPEPGTPNPLASLSVYSLINGQNYDLVFPEPREDRLIIEITWTSKMTLLVKETSRDSRHGTVVLFDFRGVRDSKFVQGHTVRDLDIDDGGWIDCRQSIKPIKSMSGDGYLDIVPNEGYNHIAFFKSSQESSPEFVTSGKWEVDIIMGVNEETNRVYFSAAYPTPIDKHILSVTLPDNDKINVLEKDRPLNLTDISVPAKYSAIFNKAASFYVLNYDGPDVPTQEIRQAIEVHKPKIIETNEALNNTLKEYSLPKVIYDTIVIDNIEYQIKEVRPPQLSEDGWSKRPVLFQVYGGPDSQVVTRNFKVTWGDYLATSNGYITVYVDVQGTGNRGRQYRNVVRDNLGKVEAEDVIKVAKHYSSKTYVDSSKIGIWGWSYGGYLSAKVMEADSDVFSLGISVAPVTNWKLYDSVYTERYMSTPKNNPDGYLNSAVRNVTGFHNYALAHGTGDDNVHFANTAHLLDMFTENSIKNFRFRAFTDSNHSMGTRNAYRELMDWLTRFLNEQWKTQKSKGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD14</accession>
    <name>I4YD14_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958158.1">
        <property type="nucleotide sequence ID" value="XM_006958096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD14"/>
    <dbReference type="GeneID" id="18475467"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68769"/>
    <dbReference type="HOGENOM" id="CLU_671224_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD14"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM21856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="410" mass="47186" checksum="122D70093FE02B13" modified="2012-09-05" version="1">MPILNFGDDDDAALKEKYYTYETLNHTEGEDKAYEAAFQEGINVPSDKWLPIDNFLNRTFYINKTQGIPAFPYKQEISRREGPAVLGKLIKFPEVEASLNQFLQTRHYAPKELVTVNIDSIMYHGLPGCIAFHIECPPIGRPDGYEDDLITEIDLGDENEKNAYNRKVQEMNATYRRIRNLYILLPRENPYADDLDKRKPKWPVMLEKTSDPLFTDFFKEWLNGALGMTFKSERINLGDNILDTLIEEAWYYAEKHDKHSRNAEYLQINWENTSTEKNENLDGINFSVKLADVSKLVKSGRKNSSNIPLLLPRLKEVVEANTGLRINSLMPTRVGVSGYLIDVTGKPKVKVLSYMLTGEEFTHEKELVEEFRFANFCKWLVNATNIVNVSFDKEGNKRTPLDTILDPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD46</accession>
    <name>I4YD46_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_60287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958189.1">
        <property type="nucleotide sequence ID" value="XM_006958127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD46"/>
    <dbReference type="STRING" id="671144.I4YD46"/>
    <dbReference type="GeneID" id="18473866"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60287"/>
    <dbReference type="eggNOG" id="ENOG502S3JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090055_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD46"/>
    <dbReference type="OMA" id="MSWFTEM"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM21888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="160" mass="18316" checksum="1261648B9519928B" modified="2012-09-05" version="1">MSGRYTYFDSDDYRLPEGMKRVGYDSDTQQYTFRDNEGYYIGQPGAEYGGRLTYTGPLTGNERDDDSEFIAPPINAPNSPYRPLLPFFVIVAVILLLLVKFIYSGNTSICPDDLIEYKISRGDTCWDISQTHSVALDWLQEKYNCDKLIPGTRMCLPRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD50</accession>
    <name>I4YD50_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_60291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958193.1">
        <property type="nucleotide sequence ID" value="XM_006958131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD50"/>
    <dbReference type="STRING" id="671144.I4YD50"/>
    <dbReference type="GeneID" id="18473867"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60291"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_21_0_1"/>
    <dbReference type="InParanoid" id="I4YD50"/>
    <dbReference type="OMA" id="HLESTHN"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="7"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113183" checksum="1296E55B20E9B776" modified="2012-09-05" version="1">MASSDSSIAVSVRVRPLTGKENGLIEPLSSNIFSSDASLSYTPSKQPVRSSRRIIDVLDDRVLIFDPPDNDPARSFQNQGFTRPGTKRYKDQRYAFDKVFGEPTSQENVFYETTLPLIDGVLDGYNATVFAYGATGCGKTHTISGTPEDPGIIIRTMNELFTRIQQVETTYNVQVSLSYLEIYNEMIRDLLAPPDAKTPRSGLALQESAAQKISVAGLSEHHPSSPEQVLAMIMDGNKKRTMSPTMANATSSRSHAVLQINVKKRQVGHDAEQCATLSIIDLAGSERASATQNSGKRMTEGANINKSLLALGNCINALCEGAKGHIPYRNSKLTRLLKFSLGGNCRTVMIVCVSPFSQHYEDTQNTLKYANRAKNIKTKVSKNIINVDRHVREYVQMIAELREQNAKLQNIIDDRSTEMSAADQRKRASSFEEMTRIKTDISQKLDETLPSIVKGAAWDALLITSTMRAQPLEARLGNLSQNPSGNSHEIALLSSMLRPLAGLLAGNSSARSHILQAQKSSAMLEATLRAIESKRYDGMDEQTVMQIKQYVQSCRHQVQFESEKQRSELLKNALGVMSTGLAGTTKTIAYLAKIGNALVEDVNKKSIDYDKQIGYAKALQMEYEGSNSLLSSINSHDELPPPISAVNSPVNTFDGATFQPPPPLAISLKSLSPSSMPATSLVEVTNRRLSPVRKVKTTSGSPKRVHRRLSNFDGMMASKPPPLSFGAASIAAGSQMKASFAQPAAQPPASIQPKKSFRWKDEAGEGELYESRRRQSLGRSVKPSTTIINSNGMDTDDNKSDGGWEDDDGSSVFNAAPVAVPAPAPTPGPAPASAPTSAPVQSEQKMRGPVRLEQSQQTQPQRRSSSIAMRPLGSKTLASKKSNLSNVGEDEESSFRLPQGSPMRLSSPTKRIALLDLNDQGSPSRPARGFAQPTASSARRLSKLPEPTGMGTPRMRRVRRGSNIGPMRRGRASLLAAETSVQHPHQPPQPAPSSGPVRFNPGANLKSPRKGRRSLMPLGSSRRMSAAPPLGDFSFNKPGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD64</accession>
    <name>I4YD64_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_57356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Preautophagosomal structure membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="4">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958202.1">
        <property type="nucleotide sequence ID" value="XM_006958140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD64"/>
    <dbReference type="STRING" id="671144.I4YD64"/>
    <dbReference type="GeneID" id="18472905"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_57356"/>
    <dbReference type="eggNOG" id="ENOG502QVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311507_0_0_1"/>
    <dbReference type="InParanoid" id="I4YD64"/>
    <dbReference type="OMA" id="THADAMQ"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="7">
        <location>
            <begin position="693"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="531"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM21906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="943" mass="107166" checksum="B89E3604818D17C1" modified="2012-09-05" version="1">MYSRAYCNTSYTIYRPNINLIPLRFLPPSLYYDMIINSLNGVITEPGSLDENSLLLDDAGNEVESLSTDQIVYLFNRHQLKSFYKDSVRLYTTPLHTLSDYIAASHYHLGQSQHLHTTSVNRHNSIRVALNFIKRQLSLLDELRSDFDTSSTTLLQQHSALLHHHQFHMHLVANIPISPKLEKRKEHLSGYMNLQKMEQTYQESLEFHNNHQRDYQLLDEQWVDIDNELSEFEGLLNSFDFREFDDALTEANDAFLSTGQLNMNDIDQLRQLDGFLREDVITLTNLKNSQPHLDYLTRLSYLHLQLTDISNQVAHFKHSLNATSSVQHLSRLKAMPTAYVSLLCELTRRTSFENHFKDKVSDVAELLANESRKEEIRRLALVDFRDSSHSLSATTGESFMKLAAVKPSKFLPFDVGAFDGTTNKSEVSLRGGNLVRISVEELQETIESIRTAVDKFIDSERIDIDLSAILPLFSVYESTMEYIHNLDLEWEKRASGMLLPQTTMKFKASNDVDQIKEDYEYQISELKDAHAAELERQRNAFEKDLQAVKAEATNDSQAEDMKRTITNLEERLAELVQTEQAAKRELQSKDAELNESKREHAQILTARDKDLRNIRSEMDADNAVLSHGLEMSNQEVIRLEEAVNSSQGKYIALCEALEKVLNKGADKNVGGGGINNVLMNFSKTPFDTDDVIHKLSTYVRRWQKEAKVNRERAKEKLAFRNFTRGDLALFLPTRNAAAKPWAAFNISFPHYFLKPTQTQAETLKSREWTVARIANIDEKVVEENGDNPFGLGVGVKYFLLDVEIWQPKHRRNLAKMDNLSGDTSNPFNAPEDSPKESSGQPDRLHKRRTMSTASSVASSRTRSSVGQQPPPNLLSQSPGVTTTLTKALSEEKKEDVNHSPIVPTPSPTVTTRNDRSGSGSVTGAAQDLLRNSLKRQQQNSPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD90</accession>
    <name>I4YD90_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_10435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958017.1">
        <property type="nucleotide sequence ID" value="XM_006957955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YD90"/>
    <dbReference type="STRING" id="671144.I4YD90"/>
    <dbReference type="GeneID" id="18470583"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_10435"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="I4YD90"/>
    <dbReference type="OMA" id="RQIAHME"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF129">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM21932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="525" mass="58130" checksum="9B6197E37B2C99AC" modified="2012-09-05" version="1" fragment="single">QVVATSQTSRFHSETLETLSNDVDVKGVNITVGDHDLLIDAELKLFDGVKYGLCGQNGVGKSTLLKCLGDKSLIGFPRNINALYVEQLEGSDTSVSALETVVNADRKSHMLRLRFKELHDNSLSMIREDLEIRDADSLEARARSILNGLGFTKDMQDGSIDQLSGGWRIRVALASALLIKPDILLLDEPTNHLDLPAILWLQSYLKSIDSTIVVISHDRAFLNAVTEETIVYKNHCLSYYKGNYDTYRQFLDEKQEHLKHKVEILEKQKSASEKSVNNEMTRARKSGDDKKMAAVASKQRKDRPGWNDSTRPDIVLETLEIPPKWSFDDPVPLRSSGDIVSLEKVSFRYSKLTPDVLSDVTLQITQNSRLGVIGANGQGKSTLLKLIIDELSSTVGSIVKHRQAVIKQFSQHNVDELLVCGSDKNPISLLMQESAALTEQDVRAELGKFGVKGSKAMTPLVCLSGGELSRVAFAKMLIGVTPHLLVLDEPTNHLDFLTIEALIQCIKKFNGAVVIASHDQAFINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>I4YD93</accession>
    <name>I4YD93_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WALSEDRAFT_38068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH668230">
        <property type="protein sequence ID" value="EIM21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958226.1">
        <property type="nucleotide sequence ID" value="XM_006958164.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YD93">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="18472045"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_38068"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="I4YD93"/>
    <dbReference type="OMA" id="QYMANLN"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1073"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1272"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="661"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM21935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="1312" mass="147174" checksum="8207822033466D07" modified="2012-09-05" version="1">MMLVLGKPGSGCTTFLKALANRHHEYVSVEGDLTYGGLSPQEVKEKYRGEIVMNTEEDLHYPTLTVAQTLEFAIRQKVPRIRPNGMRRSEYVKYILDALVKMFGIEHTANTVVGNEFIRGVSGGERKRVSIAETLVTRASVMCWDNSTRGLDATTAVDYVRSLRIITDITGGTTIATLYQAGEGIYELFDKVCVVDEGRCIYYGPANEACSYFESIGFYKPPRQTSADFLTSVTDIHERIIKPGWGNRAPRTPEELEKVYKNSQYYEAAVASADHTFNAENNHLGDFKTSVREDKKRRMAKTSPYTVSFIEQIYYCLIREIQLQRSQIANLRTKFITILFAALTVSSLFYDQSGSGSIFAKGSVCFFSTVFFCWVQLSDIWNGYTGREIIAKQSNEFAFYRPSAVTFARFLVDVPIIVSGILLFSIVVYFLGSLDYTAGKFFTYFCFASFNAVTFNQMYKVIESVSPNFSSAIRYCVALLAITFTLVGYTIPRYDIGNWFRWISWINPLPYNFESLLVNQFHDVNIECDLSDIVPNGVNGAEEQYQSCGIQGSRPGSLLVLGDDYVDAAFDYKYSHLWNNLGYISAFLIGFLIVTAVFTELFSQTGGRGGVTVFAKTAKSKTKASEIENPGDIESGAPETIKEKSNEDIEIGAINASDADFTFKNVTYTVTTATGEKRLLDDVTGYVKAGSITALMGASGAGKTTLLNTLSQRVTTGIITGDMLIDGKPLELNSFQRGTGFVLQGDLHDSFATVRESIEFSAILRQPRETPREEVLAYVDQIIALLELKDLEDAIIGSPGAGLSIEQRKRVTIAVELAAKPDLLLFLDEPTSGLDSQSAYSIGRFLKKLANAGQAILCTIHQPSSLLFTEFFDRLLLLAPGGKVVYQGPVGDNGSAVVDYFKRIGARECKAHENVAEYAIEMIAYGRDANGEFLDFVNAYRNSPEAAKLEAEVNKIIKEKSETPKEHTNAMTRSYSQPFFVQLKLLVQRMSRNYWRDSSYTYGQFFVTFGTAMLNGFVFFKNGTSIVNMTERNFSAFLILLIPPFTIISAAPKFFTNYEIFNRRENLSRVYSWYSFVTSYLLCELPYAFLNATIYWVIWYWPKGFSHTTDGDFRLGSPAGLTFLMIIEAFIFANWLAAWMCTMSPNVKFTMDIMPFIIILLFFVNGIFIDYAKQPVFWEYFMYYVNPYTYLLGGLIGATVSDVEIQCSSREITTFSPPSGETCLSYAGAFVETMGGYLLNGDSTGDCQYCPMSNSNAFLDQKHVFHATGWPWGYFGIFTLFSISSFALTYFFYYITKVNPPNLKLFKKLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDR7</accession>
    <name>I4YDR7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WALSEDRAFT_68580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957911.1">
        <property type="nucleotide sequence ID" value="XM_006957849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDR7"/>
    <dbReference type="FunCoup" id="I4YDR7">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YDR7"/>
    <dbReference type="GeneID" id="18475430"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68580"/>
    <dbReference type="eggNOG" id="KOG2516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008917_4_2_1"/>
    <dbReference type="InParanoid" id="I4YDR7"/>
    <dbReference type="OMA" id="WWVEVRM"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003698817" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EIM22109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="504" mass="57714" checksum="4902849D74B4DB97" modified="2012-09-05" version="1">MKLNIKLTAFLTTVVFVQIYLSPFTKVEESFNIQAIHDHLIYTPRNISKYDHFEFPGVVPRTFIGNLLLSLPLQFLKNYTSLFNLQYASRFLLGFINVITTQLVFNQVSDAFNQNAVIWMTLLTASQFHFTFWCSRALPNLFALPLVNISTFYSIRASIDRQNKGKYGIISLSTLTIAAVIFRLELILLIAPLSFQLWFNKCISLKNIIVIGVLSALTALTATISIDSYFWDQRFLWPEFNAFVFNIFQDKAKDWGVSPWRTYFLNYLPKILLTALPLSYIAILPKSDILPNETVSTSKVIVVKENDSKTQVTKAPFQPLSLLFPSLFYIFILSFIGHKEWRFIIYVIPVFNSIAGLAMARLWDLRNSKILTTKSLMIIPICALCLNLLITSFMTAVSSRNYPGGYALQEFHEIVSNDQPSAVHLDTLTAMTGATRFGELFRNNGWTYLKNEDHIPLEAEWRIAENVEAGWNVVRPIKGLRSFRLKSLEVEIGDVLYIQQRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDU9</accession>
    <name>I4YDU9_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WALSEDRAFT_32274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957941.1">
        <property type="nucleotide sequence ID" value="XM_006957879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDU9"/>
    <dbReference type="STRING" id="671144.I4YDU9"/>
    <dbReference type="GeneID" id="18471454"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_32274"/>
    <dbReference type="eggNOG" id="ENOG502RGZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_1_1"/>
    <dbReference type="InParanoid" id="I4YDU9"/>
    <dbReference type="OMA" id="NGPNWPE"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697717" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="33"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EIM22141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="383" mass="42994" checksum="643D7C226FFE63B6" modified="2012-09-05" version="1">MRHTLAALSLSTAILAQAFVPSSEDFKNLNPTSSWDHTPFPGAIHDEPLGGDYSDPSGIEPPSEEAPDSPNGEGYELVKDMQGEEFFDYFYFYADEDPTHGYVDYVDSKYAFKEGLAGMTDSGRPFFRVESTPKITGPRKSIRLESNFNYTGGVVLLDVWRVPGSVCGLWPAFWSNGETYDWPEWGEIDIIEGVNAFTENQSSFHTASGCYISEGSSNKFTGKLTHDGELARTCSAFESNNEGCGIKDNHKNTYGTPLNKRDGGVFAMQWLPEYGISTWFFPRGHIPEDIEKGKPSPSQWGKPYAHLSNDGCEISEYFKHHQLIFDTTLAGDWSGRVWAEEEIWQEETCANMTGYATAEEYIREEGEAFEDAVWEIGYVKLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>I4YDY2</accession>
    <name>I4YDY2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron uptake cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WALSEDRAFT_37703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957972.1">
        <property type="nucleotide sequence ID" value="XM_006957910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YDY2"/>
    <dbReference type="STRING" id="671144.I4YDY2"/>
    <dbReference type="GeneID" id="18472030"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37703"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_0_1_1"/>
    <dbReference type="InParanoid" id="I4YDY2"/>
    <dbReference type="OMA" id="PAVWAYY"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EIM22174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="419" mass="46481" checksum="B8B985559075A1AC" modified="2012-09-05" version="1">MTEITKPTIVILGASYGGDRAAKALVEGIGDVARIIVVDKKSHHNHIYVFPRYAVTNSHEHKAFIPYSDLKGAHLTLHGSVIEIKDNTVKLDRTFEQFNLSDEIHYDYLVYALGSTMPKSLQMDAKTMAGTKQSYVEWLRHRQGVIKTAQRLVIAGGGALGVQFATDIAERYPTKKVTIIHSRDQLLPRFDPQMHNIIYNSMKSLNIDIHLNERISLENTTVDFDGNVSEKRVFTQSGKEFDCDLLLLCTGQRPNSEFMEKLAPDSVDKNTKLIKVTRSMQLASQQPSENTKPTLDAARQASEKSISLGQDPGLHTSAHPNIYVIGDSADAFGAIKSGRYAWFQAQTAAENIIKQVRGDAESQPTQYDPGEPAIKVSIGLSRTVVQMGNEIIINDNVPEDLDAASVWRARNIDTSDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE22</accession>
    <name>I4YE22_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_60209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JH668229">
        <property type="protein sequence ID" value="EIM22214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006958009.1">
        <property type="nucleotide sequence ID" value="XM_006957947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE22"/>
    <dbReference type="FunCoup" id="I4YE22">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YE22"/>
    <dbReference type="GeneID" id="18473814"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60209"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="I4YE22"/>
    <dbReference type="OMA" id="CSIINSG"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006526231" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="191" mass="21334" checksum="947F2DB0844F4E12" modified="2012-09-05" version="1">MKSIILTIFALLALAFARDITDKVYFDIKQGPESLGRIVFGLYGTTTPKTAANFKHLSIGDKGYGYEGVHFHRVIKDFMIQSGDFQRGDGTGGYSIYGDKFDDENFEIVHDRPGLLSMANRGKDTNGSQFFITTKPTPWLNGKHVVFGEVIEGMDVVRTIENTRTSFRNKPTVAITVEKSGLLERNSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>I4YE41</accession>
    <name>I4YE41_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_28030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957498.1">
        <property type="nucleotide sequence ID" value="XM_006957436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YE41"/>
    <dbReference type="STRING" id="671144.I4YE41"/>
    <dbReference type="GeneID" id="18471023"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_28030"/>
    <dbReference type="eggNOG" id="ENOG502SDFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783484_0_0_1"/>
    <dbReference type="InParanoid" id="I4YE41"/>
    <dbReference type="OMA" id="GGVECNT"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="354" mass="39062" checksum="9911201FB4274F9B" modified="2012-09-05" version="1">MTQASILEGIKHVAILNEPIEVEEGKSSRLNDKQVVLLSEPLNETANLVEQQTVESEEGRALIDTAFGGILNQGAENDKSEDTTNEDPNANIVSDTTDNAIDEQLKSLSVSSSLDAISETNTPFKARKAPSTNRRPSIQPQLSRAAMLRMGITPPPKRTTSRESLSSTSKENEERRNIPTPKSLSTPKFEVRQTRASHLRRGSETETSTPQRRRTSSTPVDFGNTPGHKRQSLALDVKSVKAPSITPRQTRASRLRTGSESQESNEKVPTRRPSVDTFANTPGHKRTLSIPVKSINSPSIAARENRSSTLRSKRMSIDLSKSETPKRAFNLSTKVGNEKFVEFDKTKVKPIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEF3</accession>
    <name>I4YEF3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH/NADPH dependent indole-3-acetaldehyde reductase AKR3C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_60026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957600.1">
        <property type="nucleotide sequence ID" value="XM_006957538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEF3"/>
    <dbReference type="FunCoup" id="I4YEF3">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="GeneID" id="18473691"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60026"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="InParanoid" id="I4YEF3"/>
    <dbReference type="OMA" id="HFRTSWP"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="280" mass="31937" checksum="8B300C67A43982F4" modified="2012-09-05" version="1">MSYFNDFRLNDNAVILSPAYGTGTVLKGRDAAKNVLQAIQSGLRHIDCAQFYENEESVGKGIKASGVPREELYITTKYATGDIRETFRNSLLSLEVDYVDLFLIHSAKYAQPHGLMESWDLLEELKDSGKIRSIGVSNYRVDDLKQFVDTAKYKPAVNQIEFHPFVYGKAKELLSYCQSKGILVASYGGLSPITKIRHEDFDDLLNKLSQKYNLSHQALLYNWARAHNVMVVTTSSKAERLEEIKSLSGTKLDQEDVEELDRIGEKYHHRYYMSVMDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEI1</accession>
    <name>I4YEI1_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_37173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957625.1">
        <property type="nucleotide sequence ID" value="XM_006957563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEI1"/>
    <dbReference type="STRING" id="671144.I4YEI1"/>
    <dbReference type="GeneID" id="18472002"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_37173"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="I4YEI1"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="300" mass="32295" checksum="EE5DD97FCCDC80B4" modified="2012-09-05" version="1">MPAYIQPESANTQQTFPSDLLKGKVAFVTGGSSGICKQQTLALMQHGANAFIIGRNLEKAQKAASEMSNETGNTCIGYSCDVRNPQSVSQAVEQAIKDFGRLDVVICGAAGNFLAPISAMSANAFKTVIDIDLLGTYNTIKATMPHLRKSRGVYIHITATLHERATPLQVHVSAAKAGVEAISNVLAIEEGINGIRSNCIAPGPIRGTEGMKKLSYKGTTSEKSSPLGRWGTFTDINNLTLFLVSDAANFLNGQVFRVDGGERHVQPTNDYPNNLIEFQTLIKNGLIENREASKQRQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEP8</accession>
    <name>I4YEP8_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WALSEDRAFT_60073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957682.1">
        <property type="nucleotide sequence ID" value="XM_006957620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEP8"/>
    <dbReference type="FunCoup" id="I4YEP8">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YEP8"/>
    <dbReference type="GeneID" id="18473723"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_60073"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_0_1"/>
    <dbReference type="InParanoid" id="I4YEP8"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="102"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="243"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EIM22440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="362" mass="40152" checksum="760F25F2F6FFA6B3" modified="2012-09-05" version="1">MGESLGKIKNPPYINSYLLADSSNLFQNAQPFGVAPGDESHHEEEGDGLGDLHHLQAAVNINRRTSVSAESIKPNKVTTKTIIPKSDQQKAFLQESLKKNFLFKNLQTEQYDDVLNAMNKIKVTKGKWVIEEGDDGDYFYVVDSGEFSAYIRVPATSNDFDNDVTPPASCPKEFKLKNVLDYTKGGSFGELALMYNAPRAASILAKSDSELWSVDRLTFRSILLNHTYNKRNLYDNFLSEVDLLKSLHPSERSKIADALESRSYSPNEVVISQGDTGDAFYFVEQGEADIIKNGEKVGSYKKGDYFGELALLNSAPRAATVKASENQSTAENQLKVVALDAPAFTRLLGPVRDIMARHAETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>I4YEV2</accession>
    <name>I4YEV2_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WALSEDRAFT_17104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668228">
        <property type="protein sequence ID" value="EIM22494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957476.1">
        <property type="nucleotide sequence ID" value="XM_006957414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YEV2"/>
    <dbReference type="STRING" id="671144.I4YEV2"/>
    <dbReference type="GeneID" id="18470721"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_17104"/>
    <dbReference type="eggNOG" id="ENOG502QWMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_8_2_1"/>
    <dbReference type="InParanoid" id="I4YEV2"/>
    <dbReference type="OMA" id="LTHAWIE"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EIM22494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="597" mass="67404" checksum="12CE4CF7B4C231A3" modified="2012-09-05" version="1">MSFIGSDIPKLLWRSPSTHHLNKFCINGYVGQQLIGRSEPISFVENEARKRSNDMVAQMDDFDSLGMWFDGVAYVDKNLDSSMVETKSKESTIGIVGAGMSGLMVALLLDSVGIHNWEIIESSDRIGGRLYTEYFNNTKPDEYQYQEMGGMRFPVSWTKNGQTVEINDHKLVFQLGEYLNKINNNDPAWKVEFIPWIQSMENNFRDSNGVRLSDGSIPRVNDIAANPSLGESMMSANAKSAKALISNITDNVDLQKLTAENVFKAHRTQIDLGYDDVSEAGLLQKYGYDLMTAQEASGYDFVSLWDLIYDENNYFGATDWKAVDKGSAQLPNAFHPLIDGKISYKKRINKIATADDKVRLEWNDEANGNKKESKEFDYTFVASPFSVVRQWDLPKFEDSVIKNAIDNLNYGSACKTALQFKTRFWEHGEKPIGGGCDNTDRYYGIRNVCYPPYHIGSDGPAVVLSSYSSGDTGYRLASWSNDKLVEQAIESLAYLHGDQVYEQYSGNSAYRCWIKDENYAGSWASPTQDQHKMFIPSYHKTHDNIIFVGEHTSITHAWVFSALESAVRGSVQLLLHMGLVDEAKQINTEWMGRWITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2024-03-27" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF03</accession>
    <name>I4YF03_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_68014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957215.1">
        <property type="nucleotide sequence ID" value="XM_006957153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF03"/>
    <dbReference type="GeneID" id="18475329"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68014"/>
    <dbReference type="HOGENOM" id="CLU_1469333_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF03"/>
    <dbReference type="OMA" id="HTAHDIH"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM22545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="184" mass="21419" checksum="A247DA7F8BD4DAE6" modified="2012-09-05" version="1">MKETERSVRSRNALIEAISKESTTLAARLVHELEVIRKRHEQEEEELQQRHLNELLTVYSSYNKKIRPPYTDNLIARQDKNTLSENKPTIEKHEKARGSVTDINATFKKRKRDQILSLDFRDASISQAEIDDAIRQRNRFLEQAGAGQKVPHYLYQYNVADQRGSWGSLPSISSVFPDYFDSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF24</accession>
    <name>I4YF24_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Got1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_50629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957236.1">
        <property type="nucleotide sequence ID" value="XM_006957174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF24"/>
    <dbReference type="FunCoup" id="I4YF24">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF24"/>
    <dbReference type="GeneID" id="18472532"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_50629"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124519_1_0_1"/>
    <dbReference type="InParanoid" id="I4YF24"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="138" mass="15149" checksum="CBF800DFFC180779" modified="2012-09-05" version="1">MFLTDLQKIGVGLTTFGGLFSLLGVMLFFDASLLALGNVLFLSGLTLIIGIQKTVVFFTRPYKLRGTLCFIGGILLVFLKRTFIGFILESIGFLNLFGSFFPVILNFLRQIPFIGGFLNLPYISTIANKLAGSRQSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF41</accession>
    <name>I4YF41_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_68045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957253.1">
        <property type="nucleotide sequence ID" value="XM_006957191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF41"/>
    <dbReference type="GeneID" id="18475337"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68045"/>
    <dbReference type="HOGENOM" id="CLU_160285_0_1_1"/>
    <dbReference type="InParanoid" id="I4YF41"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EIM22583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="66" mass="7237" checksum="11AF31F1DB1220FC" modified="2012-09-05" version="1">MGEEKKSEDRNVASEEVLENLFELSQTLNTGLSKETLSNSLELIDDGLDPSTLADVILALRDGEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>I4YF82</accession>
    <name>I4YF82_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">WALSEDRAFT_68076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668227">
        <property type="protein sequence ID" value="EIM22624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957290.1">
        <property type="nucleotide sequence ID" value="XM_006957228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YF82"/>
    <dbReference type="FunCoup" id="I4YF82">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YF82"/>
    <dbReference type="GeneID" id="18475344"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_68076"/>
    <dbReference type="eggNOG" id="ENOG502S63G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032244_0_0_1"/>
    <dbReference type="InParanoid" id="I4YF82"/>
    <dbReference type="OMA" id="GEMTHAR"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EIM22624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="597" mass="67100" checksum="A3E165ED48F47C54" modified="2012-09-05" version="1">MTNLLEIQGYHGDRDLVDIPETGEAIYDEPQDPDTEFARTLHRIWQEKGDFSQVSSNSLLEDQLRELNDDDKQSEPEDDQPRDDSLTANDVLELKQSVLRNLGDAQNELAVALDVVNLLLSDTPRHLNEEMQLPIPKQSLGVASIETTELTSYQALKKSKISITTKTESLQSAADIFERASTQIEQVNNQNDTFWSDCLSLRDNNWSLIPSSNIRESAFDLEKAAKDLKVSYAIDEASNEIKSVSTSSFDIKPSKTGKSKLNIPSRRSKRLKLSIINGSTVEICSPSKSSDNIDDLAQNENERITSLLDSLNNAQDASFDEDCFADLLTEANQIPIVITSSAEFIAIELDANRQLTLELVGEEEFIKDDENISVKCDVLLFGLKLLRLRSYRNRANDTNQVMKNLLDLIHYESFLEDLKSLFARMTNLLKLFNVLEAGYYMQKTHASDILGVFFDEKMPSIIGTQAQINFGRGSNKIMNLTLNSPNTVYVQSGQYLQRTTISQLKTLVFSDTEVALLNAIRGICSGLGNKSIWLIDEIDRCVIGKKAEEQISIRPLITDKGCDLIVHSINKQEVFSISSNTPVYNIELTNWLRLHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>I4YFV3</accession>
    <name>I4YFV3_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WALSEDRAFT_31561</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956896.1">
        <property type="nucleotide sequence ID" value="XM_006956834.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="I4YFV3">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YFV3"/>
    <dbReference type="GeneID" id="18471329"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_31561"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_2_0_1"/>
    <dbReference type="InParanoid" id="I4YFV3"/>
    <dbReference type="OMA" id="WQVTRKA"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="21">
        <location>
            <begin position="2215"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="22">
        <location>
            <begin position="3176"/>
            <end position="3701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2170"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2654"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="2172"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="2182"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="2192"/>
            <end position="2209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EIM22845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="3922" mass="431212" checksum="355BEDE9DA3B8C1C" modified="2012-09-05" version="1">MSILNAAKSLVGIEEQRTLTVQSSQSRIGIPVSRNVWWKAEILRENFLQSTHSQLEQEENSEDDYAQLELLSKFLKYVATSDPDEQSLYVLQASLVHFHQVHLTNIDVHNLTAKLDADLRKLVLSAYFKSKASLEAANLETPKSPAAALIEQSLQGNANVYALFGGQGANEVYFDELQNLFDIYQPYVEDFLAQSSKTLVELAKDATNNGSVHFSQSIDVINWLRNGDKRPSVAYLASIPLSLPLIGLTQLVQYLAFASACSLSPGKLRENIKGATGHSQGVISAVVAAASDSYQEFTNNALKALKVLFYIGLRGQETFPTLSIEPALIEDSIEGGEGEPTPMLSVSGLSLSVLESFVNKTNAHLADSSKISVRLLNGPKNFIVTGPPRSLYGLVTNLRKVRAPTGLDQSKVPFSKRKAVFNARFLVVGVPYHSSYLESATPKVINDDLANEELWTPSDLKLAVYHTETGQDLRELSSGLTKSLVSQIFTQPIHWTKATDFPTSATHAIDFGPGGMSGIGPLTQRNWEGRGIRVLIPGANGKTGSEIYDSSLIKEEKWNEKFQPALVKTKDGKIHLDTPFSRLLGKPPLMVAGMTPSTVKGGFVSAVLNAGYHIELAGGGHYNAKMLRAKVAEIQDNVQPGNGLTLNALYINQRQFTFQFPLWQQMRQEGLPIEGFCVAAGIPSSEKATEMITALKESGIKHVAFKPGSVEGIRQVVNIASANPSFPIIMQWTGGRAGGHHSCEDVHQPIIQTYASIRQHSNISLVAGSGFGAAEDFWPYLTGDWSLEFGLQPMPFDGALFASRVMVAKEAHTSASVKQLIVDAPGVDDKDWENTYDKETGGILTVRSELGEPIHKIATRGVKLWREFDDTVFNLPREKRGPWLDSKRDYVIDRLNKDFQKPWFGEKADGTVVSDIGDMTYEEVTKRMVKLLYVGHQSRWIDLSLRNLVGDWLRRVEERFSAVDGTEKISILQSYSELDQPADFINKFFDEYTGAKEQLLAAEDKAYFLNITQRPGQKPVPFIPVLDNSFEVWFKKDSLWQAEDIDAVVDQDPQRVCILQGPVAAKHSTKVDEPIKELLGGIEEQLVKKLLERRYNGDASKVPEVDYIGAQPVNESSTQLESYKIISTTEQDKQTYQISDSLPPTEEWLESLAGSQVGWFRALVTTPIVVQGKGYTTNPMKKLLAPRRGQKVVIDLKNGQPIGAEFYGGIRSAGSSDPSFQAVKISYNESAGRITLVLSEERRGESVPLTFEYEYKPAIGYAPIHEVMEGRNQRIKDFYWQLWELGAPTQLNVRDTFTGPPVTIDAATVEKFCAIIGNDGEAFKSNRTDEVQAPMDFAIVTGWQAIMKAIFPKEIDGDLLKLVHLSNGFKLVSGARPIAVGDVCSAEAKIVSIVNSDSGKTVMVKGFVMRDGKPAIEVSSSFLYRGKFEDYENTFEIIDESQYRVELKSDSDVALLRSKEWFQWDDESKPLTVGTSLIFDVQSELHYGNATSYKSLNVSGRANIRNQLKELVPVGTVELESGLTKGNPVIEYLRRNGKVISGTTLFENDGYSLTKSSNPSLYVSPFSNESYSKISGDFNPIHVNPYFADLGNLPGTIAHGMYGSAATRKYVETVAADNVPSRVLSYQVTFVGMVLPGDTLEVKLRHIGMDDGAKIISVDTVNQDGDKVISGQALVAQPTTTYVFTGQGSQEQGMGMALYESSEAARKVWNAADDHLGEVYGFSIIDIVKNNPKAKTIHFGGLKGQAIRQRYMDLRYDTTDKEGNVKTLPLFPDITVRTSDYTFQAPNGLLFATQFAQIALVVTEKAAFEDMRSKGLVQSNCAFAGHSLGEYASLASIADVLPISSLTDVVFYRGLTMQRAVERDAFGRSQFRMMAVNPSRIGKTFDESILREIVDSVSRRTQLLLQIVNFNVDGQQYVCAGHLQALETLTNTLNFMKVKKIDISALLKQLSVEQVKAHLDEIIDECFGTAKAKADKEGGFLTLERGFATIPLPGIDVPFHSRYLWAGVMPFRTYLSQKIDAKDLNPDMLIGKYIPNLVAKPFEISKPYIEMIYNQTNSPRLEKVLSGWDSEKWSAPENRQVLAYTTLVELLAYQFASPVRWIETQDLFFTHYNFERYVEIGPSPTLSGMATRTQKLKYEGLDTAQAITRTILCHAKNQKEIYYEIEDEVEEAAAPAEESAPAPTPAAPVPTPAAAAPAPAPSAGGAPADIPDEPLKATDTLRIIIAQKLKKGVSEVQLGKSIKDLVGGKSTLQNEILGDLQTEFGNAPEKGEELPLDELGSALNVGYSGSLGKFTAGLVSRMVGSKMPGGFNLSSVKTHLSKTWGLGPQRQEAALLFAVTMEPAKRLGSEPEAKQWVDSIAHAYAGQAGITLTTASAGGAGGGAAAGGVTISSEELDKFRAEQNEFASHQVDAYMRYLNRDPRAGHRLHEQEKQNAAALQDRLDAIAREHGDAYINGVMSSFDPLKARTFDSSWNWARQDALAMFYDIIFGRLTTVDRDITSRCLNIISRADPTLIDYMSYYIGNVNVELGPTYKLAKELGEQLLENCREAVKEGEGPKYKDVTFPTAPHTEVTAKGDIVYSEINREDVRKLEHYVKEMAAGGKISTQNVNLDKVQSDVEKLYELVKSQPQISETHKTSIKSLYDEVLRSLGRPASIQAPPPRTRRSSSQFLRPEVSENATVHDDKLPFLHLKRKVGTNWQYSTKLTEIYLDILTEIATSGTTFKDKNALLTGVGKGSIGVEIVKGLIAGGARVVITTSRYSRATVEYYQAVYHECGSRGSSLTVVPFNQGSKQDVEQLVEYIYSTLGMDLDYVLPFAALPENGREIDGLDDKSELAHRIMLVNVLRLLGAVKAKKAARNFVTRPTQVVLPLSPNHGLFGNDGLYSESKISLETLFNRWSSESWGDYLCLAGAVIGWTRGTGLMSATNIVAEGVENHGVRTFSSKEMAFNILGLMHPLLFDITQVEPIWADLNGGMDRLPDLAQISTKLRQDLQADAARRRAISADNSADFATVNGVEAEGLYKEVKVAPRANFKYGFPDLSKPEVFGDLGKLEGLIDLDKVVVVSGFAEVGPWGSARTRWEMEARGEFTIEGCIEMAWMMGFIKHFDGRLKSGQLYVGWVDSKSGDPVDDKDVKPRYEKPILEHTGIRLIEPELFKGYDPKRKGFNQEIELNHDLEPIEVSDADAEKFRNEHGDKVDIWQSESGEWSVKLKRGARVLVPKAFHFNRLVAGQLPTGWDAGRYGIPADIAAQIDRTALWSLVAVTEALVNSGITDPYEIYKYVHPSEVGTSLGSGMGGMEALSAMFKDRREEKDVQMDILQETFINTVAGWVNLLLMSSSGPIKIPVGACATALQSLDIACDTLLTGKAKVMIAGGFDDFSEEGSYEFANMKATSNSETEFANGREPNEMSRPTTTTRAGFMESQGTGVQVLMTASTAIKMGSPIRGVIGFTSTSSDKAGRSIPAPGKGLLSVGREIHSDVPIPTLDINYRSRQMQFRRKQVSEWLDNELELLSEEFAAIEKSGGKVDEATIKARTSFLEEEAERQEKQALASFGMLEGTDARIAPLRRALAVWGLKADDIGLCTFHGTSTKANDKNESETYNELFKHLGRTEGNACPVIAQKWLTGHPKGGAAAWMFNGAVQAINDAIIPGNRNADNISAEMQAFKYLVYLSKSIKVDAIKCGILTSFGFGQVGGSCLIVHPAYLYAALSQESLEQYAKLRADRERDSYKKLNAHMIHNNLVQIKETPPFASETEIPVLLNPLARTENDNKGSYSFPKKLNEKLSYKTGNAGVASEMLKSVDGVQGVGTDAVLISAVPVSNPTFVERNFTTGEVAYCEKQPDSKASFAARWAAKEAVFKALNTKGKGAAASMKEIEVVSSETGPTVKLHGDAAKAANERSVKEFKLSLSHSEDVAIALAFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG29</accession>
    <name>I4YG29_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WALSEDRAFT_59685</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956967.1">
        <property type="nucleotide sequence ID" value="XM_006956905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG29"/>
    <dbReference type="FunCoup" id="I4YG29">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG29"/>
    <dbReference type="GeneID" id="18473499"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59685"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="InParanoid" id="I4YG29"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="257"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EIM22921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51615" checksum="52A196A83B789B4C" modified="2012-09-05" version="1">MSEGKPALPKEVTNYLPDFLQNAMDNNPYFSAGFGLMGVGAVLAGLRRGVTFGAGAAQRRLLISLEIPSKDPAYLWFLEWLSAKGKRDTATITSLPNKQPRIDAPLKLYSHQLSVETSEKKHRDQNNVTFSLVPGPGTHYFRYKGAWMQVKRERDGKMMDLTSGTPWETVTLTTLRKDSNLFADLLDESRKLAEQEAQGKTIVYTSWSIEWKPFGKPRRRRELSSVVLDKSVKSRVTEDIDKFQNRGQWYAERGIPYRRGYLLHGPPGSGKSSFIYALAGHFKYNICLLNLSEKGLTDDRLNHLLVNAPERSIILLEDIDAAFNKRVQTGADGYQSAVTFSGLLNALDGVASGEERIIFMTTNHLSKLDKALIRPGRVDLIELLGDANIEQADELFTRFYPDAKDEERTSFTDKLQEGFNGGYSVSMASLQGMFIRTSPEEAIKYLPMLFEIRNNEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG85</accession>
    <name>I4YG85_WALMC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WALSEDRAFT_27671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957018.1">
        <property type="nucleotide sequence ID" value="XM_006956956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG85"/>
    <dbReference type="FunCoup" id="I4YG85">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG85"/>
    <dbReference type="GeneID" id="18471005"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_27671"/>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_25_1"/>
    <dbReference type="InParanoid" id="I4YG85"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003697680" evidence="4">
        <location>
            <begin position="18"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EIM22977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="644" mass="74165" checksum="5570C0210A58EB30" modified="2012-09-05" version="1">MKLTSVFFLTVTGLTTALPILEGRDSGNHLIESIKKATNEIENVNARTIDNVNKRDFNSFIEGVKDTGNDIKNVFNPDKRDFIDDVTKFGNQLMSLSARDFDRTEIIRLILQSLESLDLKESFNTLTRESNVDLEIEEIRSLKSAIINGQWNLSIQLLEQLNLDDNNLKSSMELIYVQQYKELLSSGNDQKAIQVLRNYLTPLLHDQNDKIKQLSCLLMSPFLIDNLKQSRSIVLKDLENFIQSDLLLPNNRLFTLLNQSIQYQSDNFFYVSNTNEVSLLNDLKNDSLSFPNYNNSLIKAHKDEIWHCSFTKDETYFATASKDKSIIIWSIDYTNNSIKKIKHLKDFDQDVSVIKFSNDQSTFIIAIENVLIFYETVNYTVKFKSDDQHDETISNLLFTFDDSILYSTALDQKLLEWDLNGNLLYKWDQLPIRITDSLLTPNNKSIILIGPDGPQPTLSPDGTLSYTEEMRRLMIYDLTTRDCIWQIEMKNEISSLSVSLDSSQLLFNYAPNELQLWDLNNRCLIKKLYGHRQSQHVIKSSFGGYNENFIISGSEDSNIYVWHRKSGKLIQILKGHQIGCVNSITWLSNKPLICSVGDDSFIRFWSTKDSNQVQLNFINDDNDSVHYQDGSNSDNEENINMTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>I4YG98</accession>
    <name>I4YG98_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WALSEDRAFT_43896</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5"/>
    <dbReference type="EMBL" id="JH668226">
        <property type="protein sequence ID" value="EIM22990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006957030.1">
        <property type="nucleotide sequence ID" value="XM_006956968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YG98"/>
    <dbReference type="FunCoup" id="I4YG98">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YG98"/>
    <dbReference type="GeneID" id="18472310"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_43896"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_0_1"/>
    <dbReference type="InParanoid" id="I4YG98"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EIM22990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <sequence length="278" mass="31112" checksum="71703314C79C3F38" modified="2012-09-05" version="1">MPTSKNQKTQKTSRSIFERITQQGAIDLANEQEENIYLFVPNLIGYLRIVFAALAVRSMKDHPKVCAVLYCISAILDVADGMAARSFNQTSKLGGVLDMVTDRCSTTSLMVFLSSAYPDWSTLFQFLIALDFSSHFIHMYASLVTGATSHKLIQSEVSKILWLYYNNRITLFIFCAGNEIFFVALYIIYTSKLPAIGLSAALVHSLVPDVLKQQISAAAFENFTNYVININPAHLVAIVTFPICFTKQVINVVQFWKASKTLVGVDLSERANNRQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGM7</accession>
    <name>I4YGM7_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 32 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WALSEDRAFT_67437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956520.1">
        <property type="nucleotide sequence ID" value="XM_006956458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGM7"/>
    <dbReference type="GeneID" id="18475254"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_67437"/>
    <dbReference type="HOGENOM" id="CLU_2335244_0_0_1"/>
    <dbReference type="InParanoid" id="I4YGM7"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EIM23119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005242"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11247" checksum="5A41DAFCE3D56BCC" modified="2012-09-05" version="1">MAPSTCRSMFHLYQKTEVSKSSKSASRTTTESENSLSYLWLVFTNIRFSLGPAPINIPHDNKIKLRAVIDNSQIDLFVQNRIHFALMVFFQHGRVSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-09-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>I4YGQ2</accession>
    <name>I4YGQ2_WALMC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WALSEDRAFT_59455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66)</name>
        <name type="synonym">Wallemia sebi (CBS 633.66)</name>
        <dbReference type="NCBI Taxonomy" id="671144"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Wallemiomycotina</taxon>
            <taxon>Wallemiomycetes</taxon>
            <taxon>Wallemiales</taxon>
            <taxon>Wallemiaceae</taxon>
            <taxon>Wallemia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="217" last="226">
            <title>The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction.</title>
            <authorList>
                <person name="Padamsee M."/>
                <person name="Kumar T.K.A."/>
                <person name="Riley R."/>
                <person name="Binder M."/>
                <person name="Boyd A."/>
                <person name="Calvo A.M."/>
                <person name="Furukawa K."/>
                <person name="Hesse C."/>
                <person name="Hohmann S."/>
                <person name="James T.Y."/>
                <person name="LaButti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Miller K."/>
                <person name="Shantappa S."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
                <person name="McLaughlin D.J."/>
                <person name="Spatafora J.W."/>
                <person name="Aime M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22326418"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.01.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4683 / CBS 633.66</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH668225">
        <property type="protein sequence ID" value="EIM23144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006956542.1">
        <property type="nucleotide sequence ID" value="XM_006956480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I4YGQ2"/>
    <dbReference type="FunCoup" id="I4YGQ2">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="671144.I4YGQ2"/>
    <dbReference type="GeneID" id="18473362"/>
    <dbReference type="KEGG" id="wse:WALSEDRAFT_59455"/>
    <dbReference type="eggNOG" id="KOG3437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039415_3_1_1"/>
    <dbReference type="InParanoid" id="I4YGQ2"/>
    <dbReference type="OMA" id="FITIEFP"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000005242">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">U
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